LOCUS       NZ_CP024972            22562 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5961661
            Orig. end                         :: 5984223
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22562
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="28"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22562
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22562
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12562](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12562)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            449..1111
                     /locus_tag="CVV72_RS27110"
                     /old_locus_tag="CVV72_26985"
     CDS             449..1111
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104840.1"
                     /locus_tag="CVV72_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_26985"
                     /product="response regulator transcription factor"
                     /protein_id="WP_219146328.1"
                     /transl_table=11
                     /translation="MTTVFIVDDQALVRESFAGLLNARPGLDVVGQAGDGIAALAGISA
                     LATPPDVVLMDIRMPVMDGLEATRRLLEGDGEKPKVLVLTTFHLDDYVYEALRAGASGF
                     LLKDAPSAELINAIEVVAAGDALLSPAVTKRLIANFVASAPVPRPSPATFDVLTERERE
                     VLRLIAKGRSNPEIAADLVLSAQTIKTYVGRILAKLGLRDRAQAIVLAYEAGLVSPT"
     misc_feature    450..464
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.16"
                     /tool="antismash"
     misc_feature    1049..1051
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(1081..1791)
                     /locus_tag="CVV72_RS27115"
                     /old_locus_tag="CVV72_26990"
     CDS             complement(1081..1791)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_26990"
                     /product="hypothetical protein"
                     /protein_id="WP_219146329.1"
                     /transl_table=11
                     /translation="MNGKTGRWIGGVALILAPLVWCAGLLLRHLVLKDFTPEQVAWFDQ
                     QPFAAPGQLAAYAANPGFVTAAYSLFLLGAVLLLPAFLMLAKIVAAKAPALAAWGFLLL
                     AFGLFARVYFAGVELTAFELVDKLGLDHATKLVMDDYVDLSYGLWRVPVTASVGQYAGG
                     LLLAIGAFRAGTFGIVRALLFLWPCTLWMGVLKESELLSVFTAVALGLALVPLGVRVLT
                     RPADRQVGETSPAS"
     gene            complement(1993..2196)
                     /locus_tag="CVV72_RS27120"
                     /old_locus_tag="CVV72_26995"
     CDS             complement(1993..2196)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222289.1"
                     /locus_tag="CVV72_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_26995"
                     /product="cold-shock protein"
                     /protein_id="WP_005163378.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDNGGGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGAKGPQATSVTVI"
     misc_feature    complement(2251..2266)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            complement(2445..2615)
                     /locus_tag="CVV72_RS27125"
     CDS             complement(2445..2615)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163371.1"
                     /locus_tag="CVV72_RS27125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_167373513.1"
                     /transl_table=11
                     /translation="MADETKPQDKSVSGVVPVQFSADAETHDIAVVATNREALRRSPFG
                     AEVPLRAASGE"
     gene            complement(2872..4494)
                     /locus_tag="CVV72_RS27130"
                     /old_locus_tag="CVV72_27000"
     CDS             complement(2872..4494)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222288.1"
                     /locus_tag="CVV72_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27000"
                     /product="thiamine pyrophosphate-dependent enzyme"
                     /protein_id="WP_219146330.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 9.6e-36, bitscore:
                     121.8, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-34, bitscore:
                     117.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILTEAQIHRVYAVVGESFLDLLDALQRERSITFVSARHDSGAA
                     FMAEAEGKLTEHPAVLLAGRGPSAANLAIGVSTAYQDESPMVVLLENPPQDPGPTSELP
                     TADLTAMFEPIAKWTGRAESPDEVPGLLVEALTRCREGRPGPTVVAVPADFWGVPFDSA
                     KPVAAVRPPATGALGRTAEAVAQLVDEARYPVVIVGGRARAARDELIAVADELALPVYN
                     AFRRQDAFPENHARYAGHLGIGIPARQLDALERADLVLALGTQLDEVTTQSFRYPTPSQ
                     TLVLVGTGIEPARRGGLTFRVDSEVEPFLRELRTVASPRQRRASAANAAVHTFMTPPDT
                     SGATRVHPADVIRAVRKLAPEDAIVTSDAGNFAQFMHRYWCFTAPRSQLGPSNAAMGYA
                     VPAAVAAKLAEPRRTVIAMAGDGGALMTGQEIETAVRYRVPVTVLVFQNGVHGPLAVHQ
                     ARKHGRLSGVTVPVTDFASWARGLGAAGYTVDDREELEPIIASALVRQRPCVIDIRTDP
                     DVVTPDIRLTSLLGAARSQQGGQ"
     misc_feature    complement(4522..4538)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.81"
                     /tool="antismash"
     misc_feature    4675..4686
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.05"
                     /tool="antismash"
     gene            4705..5937
                     /locus_tag="CVV72_RS27135"
                     /old_locus_tag="CVV72_27005"
     CDS             4705..5937
                     /EC_number="1.1.99.24"
                     /GO_function="GO:0004022 - alcohol dehydrogenase (NAD+)
                     activity [Evidence IEA]"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0047988 - hydroxyacid-oxoacid
                     transhydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0006629 - lipid metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642937.1"
                     /locus_tag="CVV72_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27005"
                     /product="hydroxyacid-oxoacid transhydrogenase"
                     /protein_id="WP_255632276.1"
                     /sec_met_domain="Fe-ADH (E-value: 2.4e-102, bitscore:
                     341.3, seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYGTGSSDEIGYDLTQYGARRVLVLTDAGVAATGWPQRIAEGIE
                     TYGIEAVVFDGVHVEPTDVSMRKAVDFARGQGEWDAFVAVGGGSAIDTAKAVNLLTSND
                     GDLMDYVNAPVGGGRAPSAPLKPLVAVPTTTGTGSESTTVCVLDVLSLRVKSGISHLRM
                     RPSLAVVDPRLTVSQPPEVTAASGMDILCHAAESYTAKPYTEFDRKRPEDRVPYCGSNP
                     LADMFAEQSLRLLSWALPAAVRDGSDLKAREAMALAATFAGLGFGNAGVHIPHANAYPI
                     AGQVRDFHPSGYPGDEAMVPHGMAVSLTAPAAFRFTFDAAPDRHIRVARLLAPDYEWPG
                     DLREHLPAVLGRIMREIGIPNGIGAVGYAESDVDSLVSGTVKQQRLLATAPREASEADL
                     AVILRESVTLW"
     gene            5931..6350
                     /locus_tag="CVV72_RS27140"
                     /old_locus_tag="CVV72_27010"
     CDS             5931..6350
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330831.1"
                     /locus_tag="CVV72_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27010"
                     /product="thioesterase family protein"
                     /protein_id="WP_219146332.1"
                     /sec_met_domain="4HBT_2 (E-value: 1.2e-14, bitscore: 53.7,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVNAEYPHWQTVPLRWKDNDVYGHVNNVVHYSVMDTVINTWLIER
                     GGLDIETGEVIGLCVESQCKYHASVSFPGDLEVGLRMGHLGRSSVRYEVGMYSKETVIA
                     EGHFVHVFVDRESRRPVPVEGLLRSALEELRTGLG"
     gene            complement(6306..8042)
                     /locus_tag="CVV72_RS27145"
                     /old_locus_tag="CVV72_27015"
     CDS             complement(6306..8042)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030767.1"
                     /locus_tag="CVV72_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27015"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219146333.1"
                     /transl_table=11
                     /translation="MSVWGLYRSALAGQWRGGLVLLACSVLESAPAFLSGRLVELAVDE
                     GFAADRPGTGLRWLAVFGLVAVIGALGSRLVWHQLGKVVEPLRDALVTAVVRGVLHDPA
                     PPRNQPDASGVARITQHVEVVRDATAGLLVQARGMIVTTVAALAGLFTVAGSLALIVAI
                     PVVVAVAVFACLLPSLARRQRALALADERTAEVAGASLSGMRDVVACGAEPLAALELYD
                     AIDTQAAAAVRVARSGAARTVVIATGGFVPLLLALLVAPGMVRDGVLTAGAALGALVYL
                     ATTMQPALRGLAATASTVVLRLIVALRRLAETAQAEPEPDGTAEPDGTAIYVRDLTFSW
                     GAAAQPVVRGLDLHLRPGERLAVVGPSGIGKSTLAGLLTGMLEPQGGRVLLGGVPVREV
                     PAALRHRMIALIPQEAYVFAGSVRDNVGLFAQTAMDGELLAAVAAVGAEPLVTRLGGLD
                     GEIGHGALSAGEAQLIALARVYASEAGVVILDEATSHLDPPAEARAERAFAERGGVLVV
                     IAHRLTSALRADRVLVMDGKETALGTHLELMDRSTRYAQLMHAWSPRLPQPSAQFFERT
                     PE"
     gene            complement(8039..9706)
                     /locus_tag="CVV72_RS27150"
                     /old_locus_tag="CVV72_27020"
     CDS             complement(8039..9706)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633046.1"
                     /locus_tag="CVV72_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27020"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219146334.1"
                     /transl_table=11
                     /translation="MAGSADRLLVTVTLLDRPRLIALILSALAGTASGLLLPGALAAAV
                     DAVVAGRPSLPEVSWLIVLGVTEIAVGLIGGILTARMTAAATAWLRRKLADRHLALGTR
                     STFADGDAISRLTGDCTGAGMVASVVVQLGSTTLISGGAVVLLALMDWRLALVFLGSIP
                     FGLMLARTHLKHTADDVLTYQEVSGELAARMVDAVAGLRTIAASGTADREAERVLRPLP
                     KLSLAGRGMWRTQARMVWRSGLLLPAVELAVLAAAGFGVLEGRLTVGQVLAALGYVALG
                     MGLITQIPLLTTLSRARSCARRINEVLDSPVPEPGDLGVVPGRGALELRGVTVEGALRD
                     VDLLVPGGRFTAIVGRSGSGKSALVNVLGGLLTPDRGTALLDGRPLDRLRPNELRAVVG
                     FAFERPALLGATIGDAVGYGSWAGDAAVRAACRSAQVDDLIVRLPDGYRTPLSETPLSG
                     GEAQRIGLARAIAHAPRVLILDDATASLDTVTEAAVEEAIERTLPGRTRVVVTHRAATA
                     SRADTVVWLEDGRVRAVGTHDGLWRDPAYQAVFTEGAQ"
     misc_feature    complement(9737..9752)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.72"
                     /tool="antismash"
     gene            complement(9818..9961)
                     /locus_tag="CVV72_RS27155"
                     /old_locus_tag="CVV72_27025"
     CDS             complement(9818..9961)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="CVV72_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27025"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_091598068.1"
                     /transl_table=11
                     /translation="MELVLDLQALETPEVLEGGGGGSHGGASNLSLLASCANSTVSLLT
                     CH"
     CDS_motif       complement(9899..9961)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MELVLDLQALETPEVLEGGGG"
                     /locus_tag="CVV72_RS27155_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9818..9898)
                     /prepeptide="core"
                     /locus_tag="CVV72_RS27155_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="11.50"
                     /molecular_weight="2356.6"
                     /monoisotopic_mass="2355.2"
                     /core_sequence="GSHGGASNLSLLASCANSTVSLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MELVLDLQALETPEVLEGGGG"
                     /leader_location="[9898:9961](-)"
                     /alternative_weights="2374.6"
                     /alternative_weights="2392.6"
                     /alternative_weights="2410.7"
                     /alternative_weights="2428.7"
                     /alternative_weights="2446.7"
                     /alternative_weights="2464.7"
     misc_feature    complement(9971..9984)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.53"
                     /tool="antismash"
     gene            complement(10001..12562)
                     /gene="lanKC"
                     /locus_tag="CVV72_RS27160"
                     /old_locus_tag="CVV72_27030"
     CDS             complement(10001..12562)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330827.1"
                     /locus_tag="CVV72_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27030"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_219146335.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1329.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.5e-10, bitscore: 37.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.5e-07, bitscore:
                     27.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVRYEAYCFADPLFFDEQRENGDVADDFAALLPAPEAGWRTGVR
                     GVWRLLHPVARNLPLQGWKIHVSAGLGNAERVLVKVHEHCVEHEVSYKHLRSRSTLLAR
                     NSKYAPRDGSGKLLTLYPADNNELERVLAELSAKLDGEPGAYILSDLRYGAGPLYVRYG
                     GFAEQWVELDGKRVLAVRKPDGTLVPDKREPTFSVPDWVTIPEFLAPHLAARKSGGADQ
                     FPYQVKSSLHFSNGGGVYLADRKTDGEQVVLKEARPFAGLDRDEVDAVERLRREHEVLE
                     RLKGIVGIPATYDRFTVWEHHFLAMEYMPGVSLGNWLARNYPLTRRDTTEADIAAYTER
                     ALALVRRVEAMVGEVHGRGIVFGDLHSLNILVDEGTEDTEDTDTVSLIDFEMASDIESG
                     KRPALGAPGFRAPRDRNGFEVDEYALAVLKLWIFLPLTTLLELAPAKLRGLADFVQQRF
                     DVPEGYADSIVAELAPRNTPPLTSVTELDQDKPDWALVRKQITEAILASATPERADRLF
                     PGDIEQFRVGGACFGYGAAGVLYALKTVCGERHREHERWLLDSIRREPPGRPGFYDGSY
                     GIAYVLEELGYRDEATKLLTASATLVEQTTDHGLEGGLSGIGLTQLHFAVSRKDNEFGR
                     QALATAVRLAEALETAAPPGDFGRAGLLNGWSGPALLFVRLFERTREEGWLSFADQALE
                     RDIEECVESDDGSLQVRDGETRTLPYAGVGSAGILMVAEELAKHRPGAKALKSLPGLRE
                     ACRGEFVIHPGLLFGRGGLMTALAMGAEPDQRVRDAIDLHLSRLAWYAVPYKGGLAFPG
                     NQLLRLSMDVVTGGAGVLLALAATLDGKAALPFLSSRTAVQ"
     misc_feature    complement(12212..12214)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12733..12748
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.96"
                     /tool="antismash"
     misc_feature    12872..12887
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            12988..13353
                     /locus_tag="CVV72_RS27165"
                     /old_locus_tag="CVV72_27035"
     CDS             12988..13353
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633043.1"
                     /locus_tag="CVV72_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27035"
                     /product="hypothetical protein"
                     /protein_id="WP_219146336.1"
                     /transl_table=11
                     /translation="MITGFAVTVAICAMLVAAWSFVQAARKKLPDNALLAGLAVVEALL
                     VAQLVIGVVLLIGGGTPGSMATYLAYLIGCLVVLPLGTFWALAERTRSSTVILGIACLA
                     IPVMVLRLHEVWAGASA"
     gene            13346..13756
                     /locus_tag="CVV72_RS27170"
                     /old_locus_tag="CVV72_27040"
     CDS             13346..13756
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163353.1"
                     /locus_tag="CVV72_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27040"
                     /product="hypothetical protein"
                     /protein_id="WP_219146337.1"
                     /transl_table=11
                     /translation="MREETEEKTVDKASGPGRILVAVYAIFALAATSRAAVQISTKFHE
                     APLAYALSAFAAVVYLLATVALARRGAGWWRVALVACAVELLGVLTVGTFSLFDREAFP
                     HATVWSVYGQGYLFIPLILPVIGLYWLRRTKP"
     gene            complement(13870..14856)
                     /locus_tag="CVV72_RS27175"
                     /old_locus_tag="CVV72_27045"
     CDS             complement(13870..14856)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633041.1"
                     /locus_tag="CVV72_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27045"
                     /product="MCE family protein"
                     /protein_id="WP_219146338.1"
                     /transl_table=11
                     /translation="MRSFGAVDPVKLALAGLTTMALGMAAALNADALPVIGGGTTYSAE
                     FSDAGGLRADNDVRIAGVKVGKVSEIDLEGDRVLVSFRVKDAWVGDATSASIQIKNVLG
                     QKYLALDPRGEAILDPGDPIPLRRTTAPYDVLEAFRDLSKTVDAIDVGQLAKSFDTISA
                     TFADTPADVRSALDGISKLSGTIASRDRQLRALLANTRQVSQTLVDRDTEVQRLIQDGD
                     ALLRAISARQQAIKNLLDGSKRLATALDGIIADNDGQLGPVLEQLDRLTSMLQRNQDSL
                     AKGIAAFAPAIRVLTNVAGNGRWIDGYLCGLVLPTFGPLNEKGCFDS"
     gene            complement(14963..15412)
                     /locus_tag="CVV72_RS27180"
                     /old_locus_tag="CVV72_27050"
     CDS             complement(14963..15412)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03666.1"
                     /locus_tag="CVV72_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27050"
                     /product="PPOX class F420-dependent oxidoreductase"
                     /protein_id="WP_370641977.1"
                     /transl_table=11
                     /translation="MPGADQPEGRDLRGARRAGDCGRALALAVTFRAAPSSILLKTFKR
                     DGTPVGTPVNIAVEGDHGYSRTYDAAWKAKRLRNDPRIEIARSTFRGTPTGEPVRGRAR
                     LLDGEEARHAAGLLARKHRLLHGFLVPLVHRLKKYKTLHYEVRLD"
     gene            complement(15331..15723)
                     /locus_tag="CVV72_RS27185"
                     /old_locus_tag="CVV72_27055"
     CDS             complement(15331..15723)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330823.1"
                     /locus_tag="CVV72_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27055"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_219146339.1"
                     /transl_table=11
                     /translation="MTELAIGQVTARTGLSVHALRFYEKEGLLAAPVKRDSNGRRVYTG
                     QDVDWLVNCTKFRASGMPLATIRAFAGLVRQGPGNEEKRLELLREHQNTVRDRIAELAD
                     CLELISRKVEIYEEHVARGTADGLWR"
     gene            15779..16735
                     /locus_tag="CVV72_RS27190"
                     /old_locus_tag="CVV72_27060"
     CDS             15779..16735
                     /NRPS_PKS="Domain: PKS_KR (31-113). E-value: 5.4e-07.
                     Score: 21.6. Matches aSDomain:
                     nrpspksdomains_CVV72_RS27190_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030758.1"
                     /locus_tag="CVV72_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27060"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_219146340.1"
                     /transl_table=11
                     /translation="MTTSQHKIGSGFDARSTAGDVLDGIDLSGKLAVVTGGYSGLGLET
                     TRALANAGARVVVPARRPADAEAALAGISGAEVDQLDLADLASVEAFARRFLGTGRPVD
                     LLIANAGIMAAPERRVGPGWESHFAICHLGHHALVSRLWPALKAAGGARVVTVSSSGHH
                     SSPMRWDDVQFERGYDRWLAYGQAKTANVLLAVRLDTLGAEHGIRAFSLHPGAILTPLQ
                     RHLRQEEMVERGWIDEHGDQADPDFKTPEQGAATQVWAATSPLLDGLGGLYCEDCDLAE
                     VAVDEGEWVGVRPYAIDPDEAARLWELSENLTGTSLG"
     aSDomain        15872..16117
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS27190_PKS_KR.1"
                     /evalue="5.40E-07"
                     /label="CVV72_RS27190_PKS_KR.1"
                     /locus_tag="CVV72_RS27190"
                     /protein_end="113"
                     /protein_start="31"
                     /score="21.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="AVVTGGYSGLGLETTRALANAGARVVVPARRPADAEAALAGISGA
                     EVDQLDLADLASVEAFARRFLGTGRPVDLLIANAGIM"
     CDS_motif       15875..15952
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CVV72_RS27190_0001"
                     /evalue="1.30E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="CVV72_RS27190"
                     /protein_end="58"
                     /protein_start="32"
                     /score="24.3"
                     /tool="antismash"
                     /translation="VVTGGYSGLGLETTRALANAGARVVV"
     CDS_motif       16223..16339
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CVV72_RS27190_0002"
                     /evalue="2.70E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="CVV72_RS27190"
                     /protein_end="187"
                     /protein_start="148"
                     /score="-2.4"
                     /tool="antismash"
                     /translation="AGGARVVTVSSSGHHSSPMRWDDVQFERGYDRWLAYGQA"
     misc_feature    16358..16360
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16732..17820)
                     /locus_tag="CVV72_RS27195"
                     /old_locus_tag="CVV72_27065"
     CDS             complement(16732..17820)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016330821.1"
                     /locus_tag="CVV72_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27065"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_219146341.1"
                     /transl_table=11
                     /translation="MRRLLVALVALAGMVSLASPAAAAPRLTLPPPTGSHPVGSTDLHL
                     VDRSRQDPWVPSGPRELMVSMFYPALVPIGPKRPYLTLAEAKALLTESGLPDVDPALVA
                     GTRTSARVDALPLPGKHALVVLSPGFGKPRTTLTGLAEELASKGFVVALIGHNYESHGT
                     AFPDGRVTECAACGSESTLLPPIRSADASFVLDTLTRPSSRWSRLIDRTRIGMAGHSIG
                     GYSTPAAMIDDRRIRAGADLDGRLWSPIPSSGIDRPFLLLGRESEYTPAGPDTTWAGSW
                     PNLTGWKRWISVAAAGHASFTDVGVLGEQLGLGKPGLLDGERGMALTRTYVSAFFDKNL
                     RGGHQPLLDGPVPGNPEIKFWN"
     misc_feature    complement(17554..17556)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17806..17821)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.05"
                     /tool="antismash"
     gene            17960..19162
                     /locus_tag="CVV72_RS27200"
                     /old_locus_tag="CVV72_27070"
     CDS             17960..19162
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666154.1"
                     /locus_tag="CVV72_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27070"
                     /product="sensor histidine kinase"
                     /protein_id="WP_219146342.1"
                     /transl_table=11
                     /translation="MPAFLKTHPRAVDRGLTILIGLSTVVTADDPEGFEWWLVSLVALA
                     SLLVRHRNPTITFAAGGTASLLHLAMGNDLKPVDVVALAGLFSVAAWGSRRRSVALLAV
                     GLFVAGSWAFYASEANTRTPGPTPPRIIIIDRLAPADTDADDHQVQDWGGFPAIGLSLG
                     VAWLAGLNTRQRRIRLSVLEQRAADLERERDTQAALAVAAERGRISRELHDVVAHALSV
                     VVLQAQGAQAELDRRPERSREALDAIVDTGRTALSEIRRLLGALGQDEPDWEPQPGAER
                     LPRLAADIRSAGTPVEFRVEGEPRPLPSTVDLAAYRIVQEALTNVLKHAGPGASVTIVM
                     RYRPGALEVEVTDDGVAAEAPSGTGHGLEGMRERVNILGGTFDAGPRPERGFAVRATLP
                     S"
     gene            19159..19806
                     /locus_tag="CVV72_RS27205"
                     /old_locus_tag="CVV72_27075"
     CDS             19159..19806
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163340.1"
                     /locus_tag="CVV72_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27075"
                     /product="response regulator transcription factor"
                     /protein_id="WP_219146343.1"
                     /transl_table=11
                     /translation="MTIRVVIADDQALVRTGLRMILDNADDIDVVGEAGDGAEAVALVA
                     ELDPDVVLMDIRMPEMDGVEATAAIAAAQRARVLVLTTFDLDEYVYAALQAGASGFLLK
                     DALAPDLLAGVRVVAAGEATLAPTVTRRLLDRVVTGLPASPPDDRLALLTGRENEVLQQ
                     LARGLSNAEIAELLFLSPGTVKTHVGRILTKLGLRDRVQAVVFAYESGMISR"
     gene            complement(19796..20440)
                     /locus_tag="CVV72_RS27210"
                     /old_locus_tag="CVV72_27080"
     CDS             complement(19796..20440)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030754.1"
                     /locus_tag="CVV72_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27080"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_219146344.1"
                     /transl_table=11
                     /translation="MRPDAVSRSALEPEQVGRKVRLREVGLGDRRVLMGFDRDMAREAT
                     PLIGGGHRHWASHRSGSSGDDIHFGIETVRGRMLVGSVCTIGADPVTGRFGYGIGIAPR
                     HQRCGYATDAITVLLAHMFGQRGFRKCEVTVYGGNLASLSLHGGLGFREEGRLRDTEVV
                     RGEIKYLVRMGITAEEFAARPLESLADLGRRGQHRRPRRGKHWRTPAAISG"
     misc_feature    20639..20654
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            20893..21774
                     /locus_tag="CVV72_RS27215"
                     /old_locus_tag="CVV72_27085"
     CDS             20893..21774
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163335.1"
                     /locus_tag="CVV72_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27085"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_219146345.1"
                     /transl_table=11
                     /translation="MDFSDELGPAPTGREQLAAELRRLRDLAGVSGRDLAQRVGISQSK
                     VSRIEAGAVVPSLPEVTAWGKELGVPVETQKRLTALTEAAYNEVHPWHSALEQPGVLQE
                     GAEEHESVATRLQVFQPSVVPGLLQTAEYARRVITLFHRQYTDNDLRAEVAKRVHRQLA
                     LYDESRHFEFLITESALRWRPGSATLLLAQLDRIASLSTLGNVRVGLIPLDTTATTLTT
                     HGFDIYEGDGGERDTSVLVEMIHGEMRTGAAKHVQIYRARWNLLQQMAIFDDEARKFLD
                     SVASNLRAETNH"
     gene            complement(21877..22092)
                     /locus_tag="CVV72_RS27220"
                     /old_locus_tag="CVV72_27090"
     CDS             complement(21877..22092)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016070.4"
                     /locus_tag="CVV72_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_27090"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_219146346.1"
                     /transl_table=11
                     /translation="MNSHIENWIRANAAFRKSSQSNEGNCVEVAKTEIIGVRNSNDPEG
                     PLVFFTRAEWAAFADGMLAGDFDHIL"
ORIGIN
        1 cccgacgtct ggtcggcgtg ctgcgggaca ccgaggccga gccggagcat gaaccgcagc
       61 cggggctcgc ggaggtgccg acgctgatcg acggctgccg ggcctccggg atcgggatcc
      121 gcgccgagat ctccggaggg gaaggcgttc ccgccctgat cgaactggcc gcgtaccgga
      181 tcctccagga ggcgctgagc aacgcggcac ggcacagccc aggggcggaa gtggacgtcc
      241 aggtgcggcg aggacccgac gggctcgaaa tcctcgtgga gaacgggccg cccacgcgcc
      301 ctgcctcccc ttcggcaggc gacggcaccg gtctcgccgg gatcgccgaa cgcgttagca
      361 tgatcggcgg ttcctacgag gcaggaccgc gggccgacgg cggtttccgc gtggccgtca
      421 agctggacct cccgggggtg gacgacgcgt gacgaccgtt ttcatcgtcg acgaccaggc
      481 cttggtgcgg gaaagcttcg ccggcctgct gaacgcgcga ccgggtctgg acgtggtggg
      541 ccaagcaggt gacgggatcg ccgcgctcgc gggtatttcc gcgctggcca cgccaccgga
      601 cgtcgtcctg atggacatcc ggatgccggt gatggacggt ctcgaagcga ccaggcggct
      661 gctcgaaggc gacggcgaga agccgaaagt gctcgtcctg acgacgttcc atctggacga
      721 ctacgtctac gaggcgctgc gggcgggcgc gagcgggttc ctgttgaagg acgcgccgtc
      781 ggccgaactg atcaacgcca tcgaagtggt cgccgccggt gacgcgctgc tctcccccgc
      841 ggtcacgaag cggctcatcg cgaacttcgt ggcgagcgca ccggttccgc ggccgtcccc
      901 ggcgacgttc gacgtgctca ccgaacgcga gcgggaagtg ctgcggttga tcgcgaaagg
      961 acggtccaat ccggagatcg ccgcggatct ggtgctctcg gcacagacca tcaagacgta
     1021 tgtgggccgg atactggcga aactcgggtt acgggaccgg gcacaggcga tcgtgctcgc
     1081 ctacgaggcg ggactcgtct cccccacctg acggtcggcg ggcctcgtca ggacgcggac
     1141 accgagcggg acgagcgcca ggccgagggc caccgcggtg aagacgctca ggagctcgct
     1201 ttccttgagc actcccatcc agagcgtgca cggccagagg aacagcagtg cccgcacgat
     1261 gccgaaggtg cccgcccgga acgcgccgat ggccagcagc agcccgccgg cgtattggcc
     1321 gaccgacgcg gtgaccggga cccgccacag cccgtaggac aggtcgacat agtcgtccat
     1381 caccagcttc gtcgcgtggt ccagaccgag tttgtcgacg agctcgaaag ccgtcagctc
     1441 gacaccggcg aagtagaccc gtgcgaacaa gccgaacgcg agcagcagga atccccacgc
     1501 ggccagcgcc ggcgccttcg ccgcgacgat tttcgccagc atcaggaaag ccggcagcag
     1561 gaggaccgct cccagcagga agagcgagta cgcggccgtc acgaagcccg ggttcgcggc
     1621 gtacgcggcc agctgtccag gcgcggcgaa gggctgctgg tcgaaccacg cgacttgctc
     1681 cggcgtgaag tccttgagca ccagatgccg cagcagcagg cccgcgcacc acacgagcgg
     1741 ggcgagaatc agtgccactc cgccgatcca tcggccggtt ttcccgttca tggcggaagc
     1801 gtcgccgatg gggacggcac ggggcagcgg gcgaaggtca ggcgggagcc tcgactttcg
     1861 tcaggttcga ggacagcgtg gcggtcctgc cggtgcgcgg acggacgaca cgcgtgatgg
     1921 gtggacgaca ccccggaaaa gcagcagggc cgcctccccg aagggatgac ggccctgctt
     1981 ggaaagcttg ggtcagatca cggtgaccga ggtggcctgc ggacccttcg cgccctgccc
     2041 gatctcgaac tccacgcggg cgttctcctc gagggtacgg aagccgttgc ccttgatctc
     2101 gctgtagtgc acgaagacgt cgccgccgcc gttgtcggga gtgatgaagc cgaacccctt
     2161 ctcggagttg aaccacttca cagtgccctg agtcataaaa tctccatatg caacacaaac
     2221 aaacaggaag ccacgtcggc agcccgggtc atgaccagac ggtttgcttc cccggaaaca
     2281 cgaggagaca ctacgcccgc tgagttctgc gagcgtgaac caacacgaac acaaaaaacg
     2341 agacctgaat cagtaaagca cacctcacgc aggccgacaa gcgtcttcac cctggtgtgc
     2401 gcagccgcac tgtacctctc ccgccggagg ctccgccgcc cgggttattc gccgctggcg
     2461 gcgcgcaggg gtacctcggc gccgaacggc gaacggcgca acgcctcccg gttcgtggcc
     2521 acgacggcga tgtcgtgggt ctcggcgtcc gcgctgaact gcaccggcac cacgccggaa
     2581 acggacttgt cctgtggctt cgtttcgtca gccatgtttt ctcccagtgt caacacaagg
     2641 ctctaagtac tgcgtgccaa caacttcacc ggtgatcgtc ccggtccata tcggaccctc
     2701 ggtgttgcgg cgattgtgcc acggccgacc gacaaaatcc ggtctccgcg accgaaagtc
     2761 ggccgagtcg tcaccggttt cccacccttt ggagcaggtg aaggcggcac cacaagggtt
     2821 tctgtgtatc ccctgagaaa aagtaccgcc cggtagtccg gcacggcggc cctactggcc
     2881 tccttgctgt gacctcgcgg cgcccagcag gctcgtcagc cggatgtccg gggtcaccac
     2941 gtccggatcc gtcctgatgt cgatcacgca gggccgttgc cgcaccagcg cgctcgcgat
     3001 gatcggctcc agctcttcac ggtcgtccac ggtgtacccg gcggcgccga gcccgcgtgc
     3061 ccacgacgcg aagtcggtga cggggacggt gacgcccgaa agccggccgt gtttgcgcgc
     3121 ctgatgcacg gcgagcgggc cgtgcactcc gttctggaac accaggacgg tcaccggaac
     3181 gcggtagcgg acggcggtct cgatctcctg cccggtcatg agcgcgccgc cgtcgccggc
     3241 catcgcgatc accgtccggc gtggttcggc gagtttggcc gcgaccgccg cggggaccgc
     3301 gtagcccatg gccgcgttgc tcggcccgag ctggctgcgc ggcgcggtga aacaccagta
     3361 ccggtgcatg aactgggcga agttgcccgc gtcgctggtc acgatcgcgt cctcgggcgc
     3421 gagtttgcgc accgcccgga tgacgtcggc ggggtggacg cgggtcgcgc cgctggtgtc
     3481 gggcggtgtc atgaaggtgt gcacggcggc gttcgcggcc gacgcgcgcc gctgccgcgg
     3541 cgaggcgaca gtgcgcagtt cgcgcaggaa gggctcgacc tcggagtcga cccggaaggt
     3601 cagcccgccg cggcgggcgg gctcgatccc cgtgccgacc agcaccaggg tctgcgacgg
     3661 cgtcggatag cggaaggact gggtggtgac ctcgtcgagc tgtgtgccca gcgcgagcac
     3721 gaggtccgcg cgctccagcg cgtcgagctg ccgcgcgggg atgccgatgc cgaggtggcc
     3781 ggcgtagcgc gcgtggttct cggggaaggc gtcctgacgg cggaacgcgt tgtacaccgg
     3841 cagagcgagc tcgtcggcga cggcgatcag ctcgtcgcgc gcggcgcggg cccggccacc
     3901 gacgatcacc accgggtagc gggcctcgtc gaccagttgc gcgacggcct cggcggtcct
     3961 gccgagagcg ccggtggcgg gcgggcgcac ggcggcgacg ggtttggccg aatcgaacgg
     4021 gaccccccag aagtcggcgg ggacggcgac gacggtgggc cccggccgtc cttcccggca
     4081 gcgggtcagc gcctcgacca gcaggccggg gacctcgtcg ggcgattccg cgcggccggt
     4141 ccacttggcg atcggctcga acatcgcggt cagatcggcg gtcggcagtt cgctcgtcgg
     4201 gccgggatcc tgcggcgggt tctccaggag gacgaccatc gggctctcgt cctggtacgc
     4261 cgtcgagacg ccgatcgcga ggttcgccgc gctcgggccg cggcccgcca gcagcaccgc
     4321 ggggtgctcg gtcagcttgc cttcggcctc ggccatgaag gccgcgccgg aatcgtgcct
     4381 cgccgagacg aaggtgatcg agcgctcccg ttgcagcgcg tcgagcagat ccaggaagga
     4441 ctcacccacc accgcgtaca cacggtggat ctgcgcctcg gtcaggatcc tcacggccgt
     4501 ctgggcgacg gacgctcccg gttggtatct aatgagaaga gcttaggcgg gcggtgatcg
     4561 gtgccgtcaa gcgatcttcc gattccggca accccggagc ggcggaatgt ccgatattcg
     4621 gaacgtgttc gagcaaggga gcacgaaaac gtgacctcag ccaccgccgg acgtgaaact
     4681 gttttcactt acggggcgcc ggccttgaag tacggcaccg ggtcgagcga cgagatcggc
     4741 tacgacctca ctcagtacgg cgcgcgccgc gtgctcgtcc tgaccgacgc gggtgtcgcc
     4801 gcgacgggct ggccacaacg gatcgccgaa ggtatcgaga cctatggcat cgaagccgtc
     4861 gtcttcgacg gcgtgcacgt cgagccgacc gacgtcagca tgcggaaggc cgtcgacttc
     4921 gcccgcgggc agggcgagtg ggacgccttc gtcgccgtgg gcggcgggtc ggccatcgac
     4981 accgccaagg cggtgaatct gttgaccagc aacgacggtg acctgatgga ctacgtcaac
     5041 gccccggtcg gcggcggccg cgcgccgagt gcgccgctga aaccgctggt cgcggtgccg
     5101 accaccaccg ggacgggttc ggagagcacc acggtctgcg tgctggacgt gttgtcactg
     5161 cgggtgaaga gcggcatcag ccatctccgg atgcggccga gcctcgccgt ggtcgacccg
     5221 cggctgacgg tctcgcagcc gccggaggtc accgccgcga gcgggatgga catcctctgc
     5281 cacgccgcgg agagctacac ggccaagccg tacaccgaat tcgaccggaa gcggccggag
     5341 gacagggtcc cttactgtgg ctcgaatccg ctggccgaca tgttcgccga gcagtcgctg
     5401 cggctgctgt cgtgggcgct gcccgcggcc gtgcgggacg gctccgacct gaaggcgcgc
     5461 gaggcgatgg cgctcgcggc gacgttcgcc gggctggggt tcggcaacgc cggcgtgcac
     5521 atcccgcacg ccaacgcgta tccgatcgcc gggcaggtcc gggacttcca tccgtccggc
     5581 tatccgggag acgaagcgat ggtgccgcac gggatggcgg tctcgctgac cgcgcccgcg
     5641 gcgttccggt tcaccttcga cgccgcgccg gaccggcaca tccgggtggc caggctgctc
     5701 gcgccggact acgaatggcc gggcgatctg cgggaacacc tgcccgcggt gctggggcgg
     5761 atcatgcggg agatcgggat ccccaacggg atcggcgccg tcggctacgc ggagtccgat
     5821 gtggactcac tcgtttccgg cacggtgaaa caacaacggc tgctggcgac ggcgccccgc
     5881 gaggcgtccg aagcggacct cgccgtcatc ctgcgcgagt cggtgacgct gtggtgaacg
     5941 ccgagtaccc gcactggcag acggttccgt tgcggtggaa ggacaacgac gtctacgggc
     6001 acgtcaacaa cgtcgtccac tactcggtga tggacaccgt gatcaacacg tggctgatcg
     6061 aacgcggcgg tctcgacatc gaaaccggtg aggtcatcgg gctgtgcgtg gaatcgcagt
     6121 gcaagtacca cgcttcggtg tcgttcccgg gtgacctcga agtcggcctg cgcatgggcc
     6181 atctcggccg gtccagcgtc cgctacgagg tcgggatgta ctcgaaggag acggtgatcg
     6241 ccgaaggtca cttcgtgcac gtcttcgtgg atcgcgaatc ccggcggccg gtccccgtcg
     6301 agggtctact caggagtgcg ctcgaagaac tgcgcactgg gctggggtag ccgcggcgac
     6361 cacgcgtgca tgagctgggc gtagcgcgtg gaccggtcca tgagttcgag gtgggtaccc
     6421 aacgcggtct ccttgccgtc catcaccagg acccggtccg cgcgcaacgc cgacgtcagc
     6481 cggtgcgcga tcaccaccag caccccgccc cgctcggcga acgcccgttc cgcgcgggct
     6541 tcggcgggtg ggtcgaggtg cgacgtcgcc tcgtcgagga tgacgacgcc cgcttcgctc
     6601 gcgtagacgc gggcgagcgc gatcagctgc gcctcaccgg cggacaacgc gccgtgcccg
     6661 atctcgccgt cgagtccgcc cagccgcgtg accagcggtt ccgcgccgac ggcggccacc
     6721 gcggccagga gttcgccgtc catcgcggtc tgcgcgaaca ggccgacgtt gtcccgcacg
     6781 gaccccgcga agacgtaggc ctcctgcggg atcagcgcga tcatccggtg ccgcagcgcc
     6841 gccgggacct cccggaccgg taccccgccg agcagcaccc ggccgccttg cggttcgagc
     6901 attccggtca ggagcccggc caaagtcgac ttgccgatcc cactcggccc cacgaccgcg
     6961 agccgctcgc cgggccgcag gtgcaggtcg agtcctcgca ccaccggctg cgcggccgcg
     7021 ccccagctga aggtcaggtc gcgcacatag atcgcggtcc cgtcgggttc ggccgtgccg
     7081 tcgggttccg gttcggcctg cgcggtctcc gccagccgcc gcagcgcgac gatcagccgc
     7141 agcaccacgg tgctcgcggt cgcggccagc ccgcgcaacg ccggttgcat cgtcgtcgcg
     7201 aggtagacga gcgcgccgag cgcggccccg gccgtgagca ccccgtccct gaccatgccc
     7261 ggcgccacca gcaacgccag gagcagcggc acgaacccgc cggtcgcgat caccaccgtc
     7321 ctggccgccc cggaccgcgc cacccgcacg gccgccgcgg cctgcgtgtc gatggcgtcg
     7381 tagagctcca gcgcggccag cggttccgcg ccgcaggcga cgacgtcgcg catcccggac
     7441 agcgacgcgc ccgcgacctc ggcggtccgc tcgtcggcca gtgccagcgc acgctgacga
     7501 cgggccagcg acgggagcag acaggcgaac accgcgaccg cgaccaccac cgggatcgcg
     7561 acgatcagcg cgagcgaacc ggcgacggtg aacagcccgg ccagcgccgc caccgtcgtc
     7621 acgatcatcc cgcgcgcctg caccagaagc ccggccgtgg cgtcgcggac cacttcgacg
     7681 tgctgggtga tccgggcgac gccgctggcg tccggctggt tgcgcggtgg cgccggatcg
     7741 tgcaggaccc cgcgcacgac ggccgtcacc agcgcgtcgc gcaacggctc gacgaccttg
     7801 ccgagctgat gccacaccag ccgtgagccc agcgcgccga tgacggcgac cagcccgaag
     7861 accgcgagcc aacgcagtcc ggtgcctggc cgatccgcgg caaacccctc gtcaaccgcg
     7921 agttcgacca ggcgaccgga caagaacgcg ggcgcgcttt ccagtacgga gcaggcaagc
     7981 aggaccagcc cgccgcgcca ctgcccggcc agcgccgagc ggtagagccc ccagacgctc
     8041 attgcgcgcc ctcggtgaaa accgcctgat aggcgggatc ccgccacagc ccatcgtggg
     8101 tgccgaccgc gcggacgcgg ccgtcttcca gccacaccac cgtgtccgcc cgcgacgcgg
     8161 tggccgcgcg atgggtcacc accaccctgg tccggccggg aagcgtgcgt tcgatcgcct
     8221 cttcgaccgc ggcttcggtg accgtgtcga ggctggcggt ggcgtcgtcg aggatgagca
     8281 cccgcggcgc gtgcgcgatc gcgcgcgcca gcccgatccg ctgcgcctcg ccgccggaaa
     8341 gcggtgtctc cgaaagcggc gtccgatagc cgtccggcag ccggacgatc aggtcgtcga
     8401 cctgcgcgga ccggcacgcg gcgcgtacgg cggcgtcgcc cgcccacgag ccgtagccga
     8461 cggcgtcacc gatggtcgcc ccgagcagcg cgggccgctc gaaggcgaac cccacgaccg
     8521 cgcggagttc gttcggccgc agccggtcca gcggacggcc gtcgagcagc gccgtccccc
     8581 ggtccggggt cagcagcccg ccgaggacgt tgaccagcgc ggacttcccc gaaccggatc
     8641 gcccgacgat cgcggtgaac cggccgcccg gaacgagcag gtcgacgtcc cgcaacgcgc
     8701 cttcgaccgt gacaccgcgc agttcgagcg cgccccggcc ggggacgaca ccgaggtcgc
     8761 ccggctcggg gaccggcgag tccagcacct cgttgatccg ccgcgcgcac gaccgcgcgc
     8821 gggaaagtgt ggtgagcaag ggaatctggg tgatcaggcc catgccgagc gcgacgtagc
     8881 cgagcgccgc gaggacctgg ccgacggtca gcctgccttc cagcacgccg aaaccggcgg
     8941 cggcgagcac cgcgagttcc accgcgggca gcagcagacc ggagcgccac accatcctgg
     9001 cctgcgtccg ccacatcccg cggccggcga ggctcagctt cggcagcggc cgcaggaccc
     9061 gttcggcctc gcggtcggcg gtacccgacg cggcgatcgt gcggagcccg gcgaccgcgt
     9121 cgaccatcct cgccgcgagt tcgccggaca cctcctgata ggtcaggacg tcgtccgcgg
     9181 tgtgcttcag atgggtgcgc gcgagcatca ggccgaacgg gatgctgccg aggaagacga
     9241 gcgcgagccg ccagtccatc agcgcgagca ggacgacggc cccgccggag atcaaggtgg
     9301 tcgatccgag ctggacgacg accgaggcga ccattcccgc tccggtgcag tcaccggtga
     9361 gcctgctgat cgcgtcgccg tcggcgaagg tcgatcgggt gccgagggcg agatgacggt
     9421 cggcgagttt ccggcgcagc caagcggtcg cggccgcggt catccgcgcg gtgaggatgc
     9481 cgccgatcag gccgacggcg atctcggtga caccgaggac gatcagccag gagacctcgg
     9541 gaaggctggg ccgcccggcc accacggcgt ccaccgcggc ggcgagcgcg ccgggcagca
     9601 gcagtcccga cgccgtcccg gcgagcgcgc tgaggatcag cgcgatcagg cgggggcgat
     9661 cgagcagggt cacggtgacc agcaggcgat cggctgaacc cgccatccca ctccttacaa
     9721 cgtgatccca acgagacgaa ccagacggca aaatgaaggc gcgggagcgg cgcacttggc
     9781 ctgtgccgct cccgcgccct cagtgatcag ccgtgactca gtggcaggtc agcaggctga
     9841 cggtgctgtt ggcgcaggag gccagcaggc tgaggttgct cgcgccgccg tggctgccac
     9901 cgccgccgcc ttcgaggacc tcgggggttt ccagagcctg caggtcgaga accagttcca
     9961 tggtgttccc tttcactagt tatctcttgg tccgccgtcc tcactggacg gcagttcggg
    10021 aggacaggaa aggcagtgcg gcctttccgt ccagggtggc ggccagtgcg agcaggacgc
    10081 ccgcgccgcc ggtgacgacg tccatcgaca gccgcagcag ctggttgccg gggaacgcca
    10141 ggccgccctt gtacggcacc gcgtaccagg ccagccggga aagatgcagg tcgatggcgt
    10201 cgcggacgcg ttggtccggt tcggcgccca tggccagcgc ggtcatcagc ccgccccggc
    10261 cgaacagcag cccggggtgg atgacgaact cgccgcggca cgcttcacgc aggccgggaa
    10321 ggctcttcaa cgccttcgcg ccgggacggt gtttcgccag ctcttcggcg accatgagga
    10381 tcccggcgct gccgacaccc gcgtagggca atgtccgggt ctcgccgtcg cggacctgca
    10441 gtgagccgtc gtcgctctcg acacactcct cgatgtcccg ctccagcgcc tggtccgcga
    10501 aggacagcca gccctcttcg cgggtgcgct cgaacagccg cacgaacagc agcgccggac
    10561 cggaccagcc gttgagcagc ccggccctgc cgaagtctcc gggcggggcg gcggtttcga
    10621 gcgcttcggc gagccggacg gcggtggcga gcgcctgcct gccgaactcg ttgtccttgc
    10681 gggacaccgc gaagtgcagc tgggtgagcc cgataccgga caggccgcct tcgagaccgt
    10741 ggtcggtggt ctgctcgacc agcgtcgccg acgccgtcag cagtttggtg gcctcgtcgc
    10801 ggtatccgag ttcttcgagg acgtacgcga tcccgtacga gccgtcgtag aaccccggac
    10861 gtcccggcgg ttcgcggcgg atcgagtcca gcagccagcg ctcgtgctcc cggtggcgct
    10921 caccgcagac cgttttcagc gcgtagagga cgccggccgc gccgtagccg aagcacgctc
    10981 cgccgacgcg gaactgttcg atgtcgccgg ggaagagccg gtcggcgcgc tcgggggtcg
    11041 cgctggcgag gatcgcctcg gtgatctgct tgcgcaccag cgcccagtcc ggtttgtcct
    11101 ggtcgagttc ggtcacgctc gtcagcggcg gggtgttccg gggcgcgagc tcggcgacga
    11161 tcgagtcggc gtagccctcc gggacgtcga agcgctgctg gacgaagtcc gcgagcccgc
    11221 gcagtttcgc cggggcaagc tcgaggagcg tggtgagcgg caggaagatc cacagcttca
    11281 ggacggcgag cgcgtactcg tcgacctcga acccgttccg gtcccgcggg gcgcggaagc
    11341 cgggcgcgcc gagcgcgggc cgcttgccgc tctcgatgtc ggacgccatc tcgaagtcga
    11401 tcagcgacac cgtgtcggtg tcttcggtgt cttcggtgcc ttcgtcgacc aggatgttca
    11461 gggagtgcag gtcgccgaag acgatcccgc ggccgtgcac ctcaccgacc atcgcctcca
    11521 cccggcggac cagcgccagc gcgcgttcgg tgtacgcggc gatgtcggcc tcggtggtgt
    11581 cgcgcctggt cagcgggtag ttgcgggcga gccagttgcc cagcgagacg ccgggcatgt
    11641 actccatcgc caggaagtgg tgctcccaga cggtgaagcg atcgtaggtg gcggggatcc
    11701 cgacgattcc cttcaaccgc tccagcacct cgtgctcgcg gcggaggcgt tcgacggcgt
    11761 cgacctcgtc gcggtccagg cccgcgaacg gcctggcctc cttgaggacc acctgttccc
    11821 cgtcggtctt ccggtcggcg aggtacacgc cgccgccgtt ggagaagtgc agcgagctct
    11881 tcacctgata gggaaactga tccgcgcccc cgctcttgcg agcggcgaga tgaggcgcga
    11941 ggaactccgg aatcgtcacc caatcgggta cggagaaggt cggctcgcgt ttgtccggga
    12001 ccagcgtccc gtccggcttg cgcaccgcga ggacccgctt gccgtcgagt tcgacccatt
    12061 gctcggcgaa tccgccgtag cggacgtaga gcggcccggc accgtaccgg agatcactga
    12121 gaatgtatgc ccccggttcg ccgtcgagtt tcgccgacaa ctcggcgaga acccgctcga
    12181 gctcgttgtt gtcagccgga taaagagtca gtaacttacc gcttccgtca cgcggagcgt
    12241 atttcgaatt cctcgcgagc agggtgctcc gcgagcgcag atgcttgtag gacacttcgt
    12301 gctcgacaca atgctcgtgc accttcacga gcacccgctc ggcgttgccc aaacctgccg
    12361 aaacgtggat tttccagccc tgcaagggaa ggtttcgagc aacagggtgc agcagccgcc
    12421 acactccacg cactccggtg cgccagccgg cctcgggagc gggcagcagg gcggcgaaat
    12481 cgtcggcgac gtccccgttt tcccgctgct catcgaagaa cagtggatcg gcgaagcaat
    12541 acgcttcgta ccggacgtcc atcgagcgcc ccctccttgg caccaatcgg atgggccatg
    12601 tgcaccatcg cgatggagaa tattccaccc gccggacacc gaacggccaa tccgccatac
    12661 cgggggttcg gatgggctgt tcagggacgt gaattcgaaa tctaccgaat ggtaggggta
    12721 cccagcgtga gatcaactct tatttcaacc acccggtcgg tgtgtaacag gagcgaaccg
    12781 gcgaagtaat ccctggtcca ggtggcggac acaataacgc gcgcccgaat cgaccgggcg
    12841 ccgaccggag gcgcttcgtg atctattcac ccgaggtctg gaccactacg ccggccgtgg
    12901 cgcccgccac gcggcccacc ggtcgcccgt cggcggtgat ccgtccggag gtacgttgtc
    12961 gccggtgaag caggtaagga ggccgacgtg atcacaggct tcgcggtgac cgtcgcgatc
    13021 tgcgcgatgc tggtcgcggc gtggagtttc gtccaggccg cgcgcaagaa actgcccgac
    13081 aacgccctgc tcgccggcct cgccgtggtc gaagccctgc tggtggccca gctcgtgatc
    13141 ggtgtcgtgc tgctgatcgg cggcggcacc cccggcagca tggccacgta tctcgcctac
    13201 ctgatcggct gcctggtcgt gctcccgctc ggcacgttct gggcgctggc cgagcgcacc
    13261 cggtcgagca ccgtcatcct cggcatcgcc tgcctcgcga tcccggtgat ggtgctccgg
    13321 ctgcacgagg tgtgggcggg cgccagtgcg tgaagaaacc gaggagaaga cggtggacaa
    13381 ggcctccggc ccggggcgga tcctggtcgc cgtgtacgcg atcttcgcgc tggcggcgac
    13441 ctcacgcgcg gccgtgcaga tcagcaccaa gttccacgag gccccgctgg cctacgccct
    13501 ctccgcgttc gcggccgtcg tgtacctcct ggccaccgtc gcgctggccc gccgcggcgc
    13561 gggctggtgg cgggtcgcgc tcgtcgcctg cgccgtcgaa ctgctcggcg tcctcaccgt
    13621 cggcacgttc agcctcttcg accgcgaggc cttcccgcac gccaccgtgt ggtcggtcta
    13681 cggccagggt tacctcttca tcccgctgat cctgcccgtg atcgggctgt actggttgcg
    13741 gcggacgaag ccctgacacg gaactcgcgt gatcagaggc gtatctcgcg tgattgaagg
    13801 cgtaactcgt gtgttccgcc tctgatcacg cgagttacgg ctccaatcac gcgagatacg
    13861 ccttaccact cacgagtcga agcagccctt ttcgttgagc ggcccgaagg tgggcagcac
    13921 cagcccgcac aggtaaccgt cgatccagcg cccgttgccc gcgacgttgg tgagcacccg
    13981 gatcgccggc gcgaacgcgg cgatcccctt ggccagcgaa tcctggttgc gctggagcat
    14041 cgacgtcagc cggtcgagtt gttcgagcac cggcccgagc tgcccgtcgt tgtcggcgat
    14101 gatgccgtcg agcgcggtcg cgagccgttt cgagccgtcg agcagattct tgatcgcctg
    14161 ctgccgggcg gagatcgcgc gcagcagcgc gtcgccgtcc tggatcagcc gctggacctc
    14221 ggtgtcgcgg tcgacgagcg tctgcgacac ctgccgcgtg ttcgcgagca gcgcccggag
    14281 ttgccggtcg cgggaggcga tggtgccgga gagcttcgag atcccgtcca gcgcggagcg
    14341 gacgtcggca ggcgtgtcgg cgaaggtcgc cgagatcgtg tcgaagcttt tcgcgagctg
    14401 gccgacatcg atggcgtcga cggttttcga caaatcccga aatgcctcga ggacgtcgta
    14461 cggcgcggtg gtccgccgca gcggaatggg gtcgccggga tcgaggatcg cttcgccgcg
    14521 tgggtcgagc gccaagtact tctgcccgag gacgttcttg atctgtatgg acgcgctcgt
    14581 ggcgtcgccg acccaggcgt ccttcacccg gaaggagacg agcacgcgat cgccttcgag
    14641 gtcgatctcg gacaccttgc cgaccttgac cccggcgatc cggacgtcgt tgtcggcgcg
    14701 cagtccgccc gcgtcggaga attcggcgga ataggtcgtg ccgccgccga tcacgggaag
    14761 cgcgtccgcg ttgagcgccg ccgccatccc gagggccatc gtggtgagcc cggcgagcgc
    14821 cagcttgacc ggatccaccg cgccgaagga cctcatcgtc tcacctcgca ggtcacaagc
    14881 ggcaaagctt aagggccgct cgtgcccatc gccaggcgaa acgttgcacc gatcgggtgg
    14941 caacgtctgt ccattgtaga cgctaatcga gccggacttc gtagtggagc gtcttgtact
    15001 tcttcaggcg gtgcacgagc gggacgagga acccgtgcag gagccgatgc ttccgggcca
    15061 ggaggccggc cgcgtgccgt gcttcttcac cgtcgagcag acgggcccgc ccgcgcaccg
    15121 gctccccggt cggagtgccg cggaacgtcg accgggcgat ctcgatgcgc ggatcgttcc
    15181 gcaagcgctt ggccttccac gcggcgtcat acgtacggct gtacccgtga tccccttcga
    15241 cggcgatgtt gaccggcgtc ccgacgggcg tcccgtcccg tttgaaggtc ttcagcagga
    15301 tcgacgaagg cgccgcgcgg aacgtgacgg ctagcgccag agcccgtccg cagtcccccg
    15361 cgcgacgtgc tcctcgtaga tctcgacctt ccggctgatc agctccaggc agtcggccag
    15421 ctcggcgatc cggtcccgga cggtgttctg gtgttcccgc agcagctcca gccgcttttc
    15481 ctcgtttccc ggcccttgcc ggacgagtcc ggcgaatgcg cggatggtgg cgagtggcat
    15541 cccggacgcc cggaacttcg tgcagttcac cagccagtcg acgtcctgtc cggtgtacac
    15601 gcggcggccg ttcgagtccc gtttcaccgg cgccgcgagc agtccttcct tttcgtagaa
    15661 gcgaagcgcg tgcacgctga ggcccgtccg ggcggtgacc tggccgatcg cgagttccgt
    15721 cactcgggcg acgatagcgt ttgacctaga gagccctcta gctcctagcg tccgccgcat
    15781 gaccacttca cagcacaaga tcggctccgg cttcgacgcg cgcagcaccg ccggagacgt
    15841 actggacggg atcgaccttt cgggcaagct cgccgtcgtc accggcggtt attcggggct
    15901 gggcctggaa accacgcgcg cgctggcgaa cgcgggcgcg cgggtggtcg tccccgcacg
    15961 tcgtccggcc gacgccgagg ccgcgctcgc cgggatctcc ggcgccgagg tcgaccagct
    16021 cgacctcgcc gacctggcga gcgtcgaggc cttcgcccgg cggttcctcg gcaccgggcg
    16081 cccggtcgac ctgctgatcg cgaatgccgg gatcatggcc gcgccggaac gtcgggtcgg
    16141 ccccggctgg gagtcccatt tcgcgatctg tcacctcggc caccacgccc tggtgagccg
    16201 tctctggccc gcgctgaagg cggcaggcgg cgcccgcgtc gtcacggtgt cctcctccgg
    16261 tcaccattcc tcgccgatgc gctgggacga cgtccagttc gagcgcggct acgaccgctg
    16321 gctcgcgtac ggccaggcca agacggcgaa cgtgctgtta gcggtgcggc tggacacgct
    16381 cggcgccgaa cacgggatcc gcgcgttcag cctgcatccg ggcgccatcc tcactcccct
    16441 gcaacggcat ctgcggcagg aggaaatggt cgagcggggc tggatcgacg aacacggcga
    16501 ccaggccgac ccggatttca aaacgccgga acagggcgcg gccacccagg tctgggcggc
    16561 gacgtcaccg ctgctcgacg ggctgggcgg gctctactgc gaggattgcg acctcgccga
    16621 agtcgccgtc gacgagggcg agtgggtcgg cgtgcgcccg tacgcgatcg atcccgatga
    16681 ggccgcgcgg ctctgggagc tctccgagaa cctcaccggg acctcgctgg gctagttcca
    16741 gaacttgatc tcggggttgc ccggcaccgg cccgtccagc agtggctgat gcccgccgcg
    16801 caggttcttg tcgaagaacg cggacacgta cgtcctggtc agcgccattc cgcgctcgcc
    16861 gtcaagcaag ccgggcttgc cgagccctag ctgttcaccc agtacgccga cgtcggtgaa
    16921 ggacgcgtgc ccggccgccg cgacgctgat ccagcgcttc cagccggtga ggttcggcca
    16981 gctgcccgcc cacgtggtgt ccgggccggc cggggtgtac tcgctttcgc ggccgagcag
    17041 caggaacggc cggtcgatcc cggacgaggg gatcggcgac cacagcctgc cgtccaggtc
    17101 ggcgcccgcg cggatccgcc ggtcgtcgat catcgcggcc ggcgtgctgt acccgccgat
    17161 ggaatgcccg gccatcccga tacgcgtccg gtcgatcagc cgggaccagc gcgacgaagg
    17221 cctggtcagc gtgtcgagga cgaacgaagc gtccgcggaa cggatcggcg ggagcagtgt
    17281 cgactcggac ccgcacgcgg cgcattcggt gacgcgcccg tcggggaagg cggtgccgtg
    17341 ggactcgtag ttgtggccga tcagcgcgac gacgaacccc ttgctcgcca gctcttccgc
    17401 gagcccggtg agcgtcgtgc gcggtttgcc gaagcccggc gacaggacga cgagcgcgtg
    17461 cttccccggc agcgggagcg cgtcgaccct ggcactggtc cgggtcccgg cgaccagtgc
    17521 ggggtcgacg tcgggaaggc cggattcggt cagtaacgcc ttggcttcgg ccaaggtgag
    17581 gtagggccgt ttcgggccga tcggcaccag cgcggggtag aacatcgaca ccatcagctc
    17641 gcgcggtccg gacggcaccc aggggtcctg gcgcgagcgg tcgacgagat gaaggtcggt
    17701 ggagccgacg ggatgtgagc cggtcggcgg cggcagcgtg agacgggggg ccgccgcggc
    17761 cgggctcgcc aaggacacca tgccggcgag ggcgaccagt gcgacgagaa gccttctcat
    17821 gaggtttccg tttctgtcga ggatcttcct gcgtccaggc tggcgcccgg cgccgtattc
    17881 gcgcgtctgc cgcaggtcgt atccggaggt ctgccgcgag agggatccgc gacgcccgat
    17941 gcggggttac gctcggctgg tgccggcctt cctcaagact cacccaagag ccgtcgaccg
    18001 cggcctgacc atcctcatcg gactgtccac tgtggtcaca gccgacgatc cggaaggctt
    18061 cgagtggtgg ctggtctcct tggtggcctt ggcttctttg ctcgtccggc accggaaccc
    18121 cacgatcacc ttcgcggccg ggggcacggc ctcgctcctg catctggcga tgggcaacga
    18181 cctcaaaccc gtcgacgtcg tcgcgttggc cggtctcttc tccgtcgcgg cctgggggtc
    18241 gcgacggcgt tccgtcgctt tgctggcggt gggtctgttc gtcgccgggt cgtgggcttt
    18301 ctatgcctcc gaagcgaaca cgcggacccc gggcccgacg ccaccgcgga tcatcatcat
    18361 cgatcggctg gcaccggccg acaccgacgc cgacgaccat caagtgcagg actggggcgg
    18421 ttttccggcc atcggcctgt cgctcggcgt ggcgtggctc gccgggctga acacgcggca
    18481 gcgccggatc cgactgtcgg tgctggaaca gcgggccgcc gatctcgaac gcgagcgcga
    18541 cacccaggcc gcgctggccg tggcggccga acgcggccgg atcagccgcg aactgcacga
    18601 cgtcgtcgcc cacgcgcttt ccgtggtggt cttgcaggca cagggtgcgc aggcggaact
    18661 ggaccggcgg ccggaacgat cgcgggaggc gctggacgcc atcgtcgaca ccgggcggac
    18721 cgcgttgagc gagatccggc ggctgctcgg cgcgctgggc caggacgagc cggactggga
    18781 gccccagccc ggtgcggagc gcctgccgcg gctggccgcc gacatccggt cggcgggcac
    18841 gccggtcgag ttccgcgtcg aaggggaacc ccggccactt ccgtccacag tggacctagc
    18901 ggcctaccgg atcgtgcagg aggcgctgac gaacgtgctg aaacacgccg gtccgggcgc
    18961 gtcggtgact atcgtgatgc ggtacaggcc aggggcgctg gaggtcgagg tcaccgacga
    19021 cggcgtcgcg gcggaagcgc cgtccggcac cgggcacggc ctcgaaggga tgcgggagcg
    19081 agtgaacata ctgggcggca ccttcgacgc gggaccacgg ccggaacgcg gcttcgccgt
    19141 ccgcgcgacc ctgccgtcat gacgatccgg gtggtcatcg ccgacgacca ggcgctcgtg
    19201 cgcaccggcc tgcggatgat cctggacaac gccgacgaca tcgacgtcgt cggcgaggcg
    19261 ggcgacggcg cggaggccgt cgcgctggtg gcggagctcg atcccgacgt cgtgctcatg
    19321 gacatccgga tgcccgagat ggacggcgtc gaggccaccg ccgcgatcgc cgcggcacag
    19381 cgcgcccgtg tcctggtgct gaccacgttc gacctggacg aatacgtcta cgccgcgctc
    19441 caggcggggg ccagcggctt cctgctcaag gacgcgctgg cgccggatct gctcgccggg
    19501 gtccgggtgg tcgccgcggg cgaggcgacc ctcgcgccca ccgtcacccg gcggctgctc
    19561 gaccgggtcg tcaccggcct gcccgcgtca ccgccggacg accggctcgc gctgctcacc
    19621 gggcgcgaga acgaggtgct ccagcagctg gcgcgcggcc tgtccaacgc cgagatcgcc
    19681 gagctgctgt tcctctcgcc gggcacggtg aagacccacg tcggccgcat cctcacgaaa
    19741 ctcggcctcc gcgaccgcgt ccaggccgtc gtcttcgcct acgaatccgg gatgatcagc
    19801 cgctgatcgc ggcgggtgtg cgccagtgct tgccgcgccg gggccgccgg tgctgcccac
    19861 gcctgccgag gtcggcgagg ctttccaggg ggcgcgcggc aaactcttcg gcggtgatgc
    19921 ccatccgcac gaggtacttg atctcgccgc gcaccacctc ggtgtcacgc agcctgcctt
    19981 cctcgcggaa gccgagaccg ccgtgcagcg aaagcgacgc caggttgccg ccgtacacgg
    20041 tgacctcgca tttgcggaag ccgcgctgcc cgaacatatg cgccaggagg acggtgatgg
    20101 cgtccgtggc gtagccgcag cgctggtggc gcggggcgat cccgatgccg taaccgaacc
    20161 ggccggtcac cgggtcggcg ccgatggtgc acaccgaacc gaccagcatc cggccgcgca
    20221 ccgtctcgat gccgaagtgg atgtcgtcgc ccgacgatcc cgagcggtgc gaggcccagt
    20281 ggcggtgccc gccgccgatc agcggcgtcg cctcgcgggc catgtcacga tcgaagccca
    20341 tcaggacccg gcgatccccc agcccgacct cgcgcaaccg caccttccgc ccgacctgct
    20401 cgggttccag ggcggagcgg ctcaccgcgt ccggccgcac gggtgctcac gaacgatcac
    20461 aagcatgcat cgacgatatc gggtgtgacg gggcgcgtcg ccgttggccc gaaccgggcc
    20521 aggcaacgct ctcgcacggg caccttgcgg ccgcctatcc cgcgagggcg aggccgagga
    20581 agaggcccac catgaatccc gcgaacatca gcttggcgac atacgagagc gtgaaccaaa
    20641 cgcgcatcat cttcctccgt caccaagttg aatcatattg aatcaaagtg aatcacttgt
    20701 gctacagtgt gtcaacgaga accgcgatca ctgcgccaac tgaggcatac atgtaccggc
    20761 gagtagccta aaggtggttg atcttggggt cggatcgcag cttgacaccg cccgacggga
    20821 ctgctggaat gactcgtacc gaatcattcc gagtcgtccc gtcgccctac cgacgggaga
    20881 tttcagagcg tcatggactt ctctgacgag ttgggcccgg cgccgacagg acgagagcaa
    20941 ttggcggccg agctgcggcg tctgcgagat ctcgccggtg tttccggccg ggatctggca
    21001 caacgggtcg gcatcagcca gtccaaggtg tcacgcatcg aggcgggtgc cgtcgttccg
    21061 tcgcttccgg aggtcacggc gtggggaaag gagttgggcg tgccggtcga gacccagaaa
    21121 cggttgacgg ccttgaccga ggcggcctac aacgaggtgc acccttggca ttcagcactc
    21181 gaacaacccg gcgtcctcca ggaaggagcc gaagaacacg agtccgtggc gacccggctc
    21241 caggtcttcc agccttcggt cgtccccggg ctgctgcaga ccgcggagta cgcgcgccgg
    21301 gtgatcacct tgtttcacag gcaatacacc gacaacgacc tccgcgcgga ggtcgcgaag
    21361 cgggtgcacc ggcagctcgc cctctacgac gagagccgtc acttcgaatt cctcatcacc
    21421 gagtcggctc tgcgctggcg gccgggttcg gccaccttgc tgctggccca gctcgaccgc
    21481 atcgcgtcgc tgagcacctt gggcaatgtg agggtcggac tgatccccct cgacacgacg
    21541 gccaccacgc tcacaaccca cggcttcgac atctatgaag gcgacggcgg tgaacgggac
    21601 acctcggtcc tggtcgagat gatccacggc gagatgagaa ccggcgcggc gaaacacgtg
    21661 cagatctacc gcgctcgctg gaacctcctc cagcagatgg cgatattcga cgacgaggcg
    21721 cggaaattcc tggattccgt cgcctcgaac cttcgagccg agacgaatca ctagaattca
    21781 agcccgttat ttccgaaaaa cgatgacctc accggggagg gagagggaaa gtggccggga
    21841 tggcctgatc ggccatcccg gccatctctt cccgcgctag agaatgtggt cgaagtcgcc
    21901 ggcgagcatt ccgtcggcga aggcggccca ctcggcacgg gtgaagaaca ccagcggccc
    21961 ttcaggatcg ttggagttgc ggacaccgat gatctcggtc ttcgccacct ccacgcagtt
    22021 cccttcgttg gattggctac tcttccggaa agcggcgttc gcgcggatcc aattctcgat
    22081 gtggctgttc atgacatcct cctgatttct ccggcgaccc gttgtcgccg tacgaagtca
    22141 gattggcccc tggaactgta cgaacagccg cacgacctac tgcacatcca gctgcactga
    22201 cggctggata tccgaccgat tcgatccgct cccgcgatcg ttcgtgtcga cggaagccga
    22261 aggcgagaga tgacgaaaga gctcgagacc cggcagggaa gcaccgtcat gttccacctc
    22321 tacgggcacg tggaggcgag cgtcggcggg gaaactcatt ccctgggagg agaacgggaa
    22381 cgtgccctgg cggccaggtt gctgctggcg aacggaaacc cggtcccgcg cgaggtcctg
    22441 ctggactact tgtgggacga gctgccgaaa tcgggggtga acctcttcca ccgcgcgatg
    22501 acactgcttc gccagagtct caccccgctc ggcatgggtg aagccctggt caatcgcgac
    22561 cg
//
