LOCUS       NZ_CP024972            23493 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3951257
            Orig. end                         :: 3974750
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23493
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="23"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..23493
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23493
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:13493](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13493
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(220..888)
                     /locus_tag="CVV72_RS17645"
                     /old_locus_tag="CVV72_17575"
     CDS             complement(220..888)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156546.1"
                     /locus_tag="CVV72_RS17645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17575"
                     /product="VOC family protein"
                     /protein_id="WP_219153408.1"
                     /transl_table=11
                     /translation="MAVQLVNLVFDSALPRDLAGFWEGLFSWDAPFQPAFRSEAGPKRG
                     KNRLHLDLASRSPEHQAGLVDRALSLGARHIDIGQGAPEEKRVPWVVLADPEGNEFCVL
                     EPREQYEGTGAIASVVTDALDPERLARFWAAALGWEIGVREESIVGLRPPDGRGPWVEF
                     LATEEEKRHRNRLRFEIAPRRGKSRAAEVRRLRELGASGERAEAMVDPEGNEFSVLSPR
                     "
     gene            complement(1006..1770)
                     /locus_tag="CVV72_RS17650"
                     /old_locus_tag="CVV72_17580"
     CDS             complement(1006..1770)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637653.1"
                     /locus_tag="CVV72_RS17650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17580"
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_125675735.1"
                     /transl_table=11
                     /translation="MAGQAMIDQGRFLEVIGAETELMAQVAHTASADAPVPTCPGWTLG
                     EVLRHVGSVYRVTRRWITDGRRPEHWQRKPGPGQSLEEYFREGRDELVAELSAHDPDEL
                     APTWWPADRSYGFWRRRTAHETTIHRIDAESAAGREVSEIPEDVALDGIDEALVLWFGQ
                     RLPLLGLSGTKTGSVGVRTAGHTWIARAGPTETVAWRCSAEEAQRADDLITGKPDKIYR
                     WLWGRAGPTAVTVSGDQDMAGQLWALLRLATR"
     gene            complement(1899..2381)
                     /locus_tag="CVV72_RS17655"
                     /old_locus_tag="CVV72_17585"
     CDS             complement(1899..2381)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156540.1"
                     /locus_tag="CVV72_RS17655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17585"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_219153409.1"
                     /transl_table=11
                     /translation="MSVSVVSPDEAERPGGTAQPALPMSLRPPAPPAAVSLYAQARRGL
                     AEAERESAPAERFIGAYLAALRGAAAVLEARGRPHRGRARPASGWVLLDSVAPELKEWA
                     AFFAANSATRAAAQAGITGKVTAELADELTRAATVFLELVRRVVHGLPMGDSAHVA"
     misc_feature    2482..2497
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: strong, score: 28.4"
                     /tool="antismash"
     misc_feature    complement(2483..2496)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 22.19"
                     /tool="antismash"
     misc_feature    2483..2496
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            2603..3133
                     /locus_tag="CVV72_RS17660"
                     /old_locus_tag="CVV72_17590"
     CDS             2603..3133
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156538.1"
                     /locus_tag="CVV72_RS17660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17590"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_219153410.1"
                     /transl_table=11
                     /translation="MSTIDRSGHPSVAKVAAALAEAGQHAAADGIRILPAEIRTAAQAA
                     EALGVEVGAIANSLVFRSRTGDAETALLALTSGAHRADTALLASVTGADEIGKADADFV
                     RAHTGQPIGGVAPVGHPKALTTLVDTALRAHEVVWAAAGHPKSVYPTTFDGLVALTGGT
                     PADVAGDGQDGRP"
     misc_feature    2996..2998
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3130..3693
                     /locus_tag="CVV72_RS17665"
                     /old_locus_tag="CVV72_17595"
     CDS             3130..3693
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332697.1"
                     /locus_tag="CVV72_RS17665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17595"
                     /product="N-acetyltransferase"
                     /protein_id="WP_016332697.1"
                     /transl_table=11
                     /translation="MTAMSSECTRYVQLSADEFRARLPEALTIYVNAMRYPEGTAEQRA
                     PMWLTHALREGWRCMAALDADGVLLGLAYGYKGRGGQWWHEQVRHGLTRREGQAAAEHW
                     MSDYFELTEIHVSPESQGKRIGEDLLRRLLDGVPSAHVLLSTPEGTSRAWNLYRRVGFV
                     DVLRDYHFAGDPRPFAILGRTLPL"
     gene            complement(3690..4571)
                     /locus_tag="CVV72_RS17670"
                     /old_locus_tag="CVV72_17600"
     CDS             complement(3690..4571)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637657.1"
                     /locus_tag="CVV72_RS17670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17600"
                     /product="DMT family transporter"
                     /protein_id="WP_219153411.1"
                     /transl_table=11
                     /translation="MSVAVPTRARSSAALVLAGVLWGTGGLAGSLLASRAGLHPLSVAA
                     YRLLIGGVIATGYLWLTGGLRGLPRAPRVRRRLLAVGGLFALFQTSYFAAVSLSSVSVA
                     TMTTIGSAPVLLAVATAVKTRRLPGAWTAVSVAGSLVGLALLQWTPGQEADVAGVLFAL
                     LAAAGFAALTLVTATRVEGLDPLPTTAFGCLIGGAALAPAALWFGMAVPVQADVLALVV
                     YFGVVPTALAYAAYFRGLESAHPVLAALSALLEPLTAALLSMVLLGERLGVVGWCGAVV
                     LIAALTVAYSKP"
     misc_feature    4713..4727
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.88"
                     /tool="antismash"
     gene            complement(4862..6547)
                     /locus_tag="CVV72_RS17675"
                     /old_locus_tag="CVV72_17605"
     CDS             complement(4862..6547)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075033.1"
                     /locus_tag="CVV72_RS17675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17605"
                     /product="DUF885 domain-containing protein"
                     /protein_id="WP_219153412.1"
                     /transl_table=11
                     /translation="MASTARTVHQICDRYVDDYAAADPVAATTYGISGYDDQLTDYSPA
                     GHAARAAIAARALADISAAEPADDGERAAKAVFTERIGLHLEIHEAGLDLAALNVIESP
                     VQELRMVFDFMPTDTAADWATIAARMARVPEALDGLRSSLLAAAAAGRVSALRQVGKVA
                     EQAETWAGLKDDDGFFETLVAGAKDVDDKLRAELGQAAHAAQEAYAEFAGFLRAELAPL
                     APVKDAVGAEVYRLWSRLFTGATFDLDEAYAWGWAEFTRIETEMREVAGRIKPGATLAE
                     AAAALDADPKYVVRGRAEFQAWMQNLSDNALKSLRGKHFDISDRVMALECKIAPPGGTV
                     GAYYTGPSEDFSRPGRMWWSLPQGRDEFTTWREVSTVYHEGAPGHHLQIATAVDQSESL
                     NKYQRLLAFTSGHAEGWALYSERLMEDLGFLADDGELFGMLSEQLFRAARVIVDIGMHL
                     ELEIPAGTGFHEGERWTPELGLEFMLTRTVTDPAHVHDEIDRYLGWPGQAPSYKLGERL
                     WLTAREEARERQGDAFDIKQFHTRALALGGMGLDTLREMLATLD"
     gene            complement(6590..7474)
                     /locus_tag="CVV72_RS17680"
                     /old_locus_tag="CVV72_17610"
     CDS             complement(6590..7474)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332694.1"
                     /locus_tag="CVV72_RS17680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17610"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="WP_219153413.1"
                     /transl_table=11
                     /translation="MTSVVERLQGDGPVFSIEFFPPRDAADEAVLWKSIRELEPLDPAY
                     MSITYGAGGSSRDGTIRSIARVATETTLVPMAHLTAVNHSVAELRNVIGWYAAVGVRNI
                     LALRGDPPGDVYGDWVPHPEGLNYAEELVELVRSLGDFCVGVSAFPYGHPRSANLEADT
                     EYLVRKLRAGADFAIAQLFFEPEDFLRLRDRVAATGCEALVIPGIMPLTTPRTLHTSIK
                     LSGAPAPRRLLDRLEPLADDPKAFRAAGIDAVTELGERLIAEGVPDLHFYTFNRSKATR
                     EVVSRLGLVPARA"
     gene            7611..8288
                     /gene="merB"
                     /locus_tag="CVV72_RS17685"
                     /old_locus_tag="CVV72_17615"
     CDS             7611..8288
                     /EC_number="4.99.1.2"
                     /GO_function="GO:0018836 - alkylmercury lyase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="merB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005156527.1"
                     /locus_tag="CVV72_RS17685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17615"
                     /product="organomercurial lyase"
                     /protein_id="WP_219153414.1"
                     /transl_table=11
                     /translation="MSAETDTSWDEDVRVAVYRAFAEHGRPPTAPELADAAHGSLAVAK
                     QALHRLAERRHLVLDECEHVVLAHPFAAIPLGFSVMGAHTLWWGGCAWDAFAIPHLVKA
                     EPEVLVSTRCRGCGEPHALLVNDRTPPKGELVAHFLVPVARMWDDVVYTCGNQRLFCGE
                     SCVDGWLTETGQDKGYVMDLATLWRLAAGWYEGRLEHGYVRRDPAAAAAYFGRAGVSGP
                     FWN"
     gene            complement(8357..8662)
                     /locus_tag="CVV72_RS17690"
                     /old_locus_tag="CVV72_17620"
     CDS             complement(8357..8662)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637662.1"
                     /locus_tag="CVV72_RS17690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17620"
                     /product="AzlD domain-containing protein"
                     /protein_id="WP_219153415.1"
                     /transl_table=11
                     /translation="MTLWLAIVLVALVSIGFKAAGPVLLGDRTLPPRLAGVIALLAPAL
                     LAGLVLTDVAGPAWSGLEWTLCAGLAAIAVTYALRVPVLAAILCGVVVTAALRFLV"
     gene            complement(8659..9336)
                     /locus_tag="CVV72_RS17695"
                     /old_locus_tag="CVV72_17625"
     CDS             complement(8659..9336)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_component="GO:1902495 - transmembrane transporter
                     complex [Evidence IEA]"
                     /GO_process="GO:0006865 - amino acid transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029308.1"
                     /locus_tag="CVV72_RS17695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17625"
                     /product="AzlC family ABC transporter permease"
                     /protein_id="WP_255632724.1"
                     /transl_table=11
                     /translation="MTEISTRRHSYLAGARVGLGLGVATFVLGVTFGAYSQTLGWGIAA
                     PIVASILVFSGSAQFAMATALAGGGNLAVAVGAAALINARFLPMGAAVAADLRGGRLRR
                     AWEGQAVVDGSWVAAHLGEGRFDREKLIGCTLVQLPAWILGTVLGVLAAPPPDVVSRFG
                     LDVVFPGFFLVLLIDELRRSRQAVLTAALAACLAGILVLFVPVGLALIGASAAALLGVG
                     ARR"
     misc_feature    9354..9374
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.71"
                     /tool="antismash"
     gene            9384..9932
                     /locus_tag="CVV72_RS17700"
                     /old_locus_tag="CVV72_17630"
     CDS             9384..9932
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332690.1"
                     /locus_tag="CVV72_RS17700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17630"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_219153416.1"
                     /transl_table=11
                     /translation="MDGHWDGYDSIGGSVPLDLVNTVSWRRDPARRDDRLSTPERLSEW
                     VVLVGAGTERLEISEAVLETVKAFRETLYRVLVSDPPDVTALRKPLIEAYRHASLPPSL
                     PLRWEVPLENGDALPHFLALAAENLLRTGNPERIRECEGPGCGWVFTDHTRNRSRRWCS
                     SSDCGNRARVKRHYDKTRG"
     gene            10001..11092
                     /locus_tag="CVV72_RS17705"
                     /old_locus_tag="CVV72_17635"
     CDS             10001..11092
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332689.1"
                     /locus_tag="CVV72_RS17705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17635"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_125675755.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.2e-47, bitscore:
                     158.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTSAYDADLPAHVERALAGFLERAGAEIRRTEPVVGVGIDALAG
                     FVLGGGKRLRPTFAWWGWRGAGGDPAGPDVEGVLQAVASLELIQACALIHDDLIDSSDS
                     RRGSPTVHIAGAKLHADSGWLGSPSTFGLATAVLVGDLALAWADDMFGEAPLPPAALAA
                     ARPAWRAMRTEVLAGQYLDVRTQATGDASPEAALHICKLKTAAYTVQRPLHLGAALGGA
                     DDALIATLREFGDEVGVAFQLRDDLLGVFGDPSVTGKPAGDDLREGKRTLLVALGLQRA
                     AEQGKDAAAKVISDAIGDAHLSEDAVETVREALQDVGAVDAVERRIDELTDSAMAALDR
                     AHLAEPAPAALTGLVVKATQRTY"
     gene            11092..12567
                     /gene="crtI"
                     /locus_tag="CVV72_RS17710"
                     /old_locus_tag="CVV72_17640"
     CDS             11092..12567
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637666.1"
                     /locus_tag="CVV72_RS17710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17640"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_219153417.1"
                     /sec_met_domain="DAO (E-value: 6.3e-18, bitscore: 64.3,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTVTGPSDHVVVIGGGLAGLSATLHLLGAGRRVTLLEQDKSPGG
                     RAGQADIGGNTVDTGASVLTMPELLDEAFAAVGESLADNLTLTRLDPAYRARFADGSTI
                     AVHTEAAAMEAEIRAAAGPAEADGYRRLRQWLTELYTVQKDHFIGANFDSPLDLVRPEL
                     AKLAALGGFGRLGPKIGRFLRDDRVRRLFSFQALYAGLDPARAIGAYGVISYMDTVGGV
                     YYPSGGMGEIARAMANAAERAGAELRFGTEAAWLERVSSRVRAVRTRTGERIPCDTVVL
                     ATELGTAYRLLGARPRRPLPLRYSPSAVVLHGNAPKSWPDLGHHTIFFGHAWERTFSEI
                     IREGKLMSDPSLLVTRPTATEPGLSPGGGQVISVLAPAPNLRRGKIDWRRVGPVYRTEL
                     VCTLEKRGLAGFADGFSVDETITPEGWAERGLTAGTPFSLAHTFAQTGPFRPGNLLRAA
                     ENVVLAGCGTTPGVGIPPVVISGRLAAGRITGR"
     gene            12564..13493
                     /locus_tag="CVV72_RS17715"
                     /old_locus_tag="CVV72_17645"
     CDS             12564..13493
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029312.1"
                     /locus_tag="CVV72_RS17715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17645"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_219153418.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.8e-111,
                     bitscore: 370.6, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.5e-61,
                     bitscore: 205.6, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNELDAAGITEPSLRAAYTECRRINAHYGRTFFLATRLLPARTRP
                     YAHALYGFARMADEVVDNPAPGTDPAVALDEVAAMVTQVFDGGTPADPVLTALADTVRR
                     HDLDRELFDAFLRSMTMDLKITAYATYADLREYIHGSAEVIGLQMLPVFGTVVPVAEAV
                     PGAAALGEAFQLTNFLRDVGEDLDRGRLYLPTEELAAFGVDRELLEWSRARGLPDRRVR
                     RALAVAVARNRAVYRRAEAGIPLLRPESRACVRTALVLYEGILDEITALGHDVLNTRAV
                     VPRRRRLGVALPRFLASAWSNSRLRVRT"
     gene            13490..14278
                     /locus_tag="CVV72_RS17720"
                     /old_locus_tag="CVV72_17650"
     CDS             13490..14278
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332686.1"
                     /locus_tag="CVV72_RS17720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17650"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_219153419.1"
                     /transl_table=11
                     /translation="MTTAENRKIRIGVQLQPQHAEYKAIRRAASEAEDLGVDIVFNWDH
                     FYPLYGEPEGLHYECWTMLGAWAESTSRVEIGALVTCNSYRNPELLADMARTVDNISDG
                     RLILGIGSGWFEKDYDEYGYEFGTAGGRLDNLAEALPRIESRLGKLNPQPVRDIPVLIG
                     GGGEKKTLRLVAKHADIWHGFGDPEVVERKVKILDQHCADVGRDPKEIERSVAVEGEPE
                     ELGPKLLELGVSLFTVATGGPDYNLDKLRSWIAWRDKQQS"
     gene            complement(14330..14881)
                     /locus_tag="CVV72_RS17725"
                     /old_locus_tag="CVV72_17655"
     CDS             complement(14330..14881)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029314.1"
                     /locus_tag="CVV72_RS17725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17655"
                     /product="CGNR zinc finger domain-containing protein"
                     /protein_id="WP_219153420.1"
                     /transl_table=11
                     /translation="MASAQRDFLPGRSARAAGQRAVDLLEVLLAPEPSVASVRAVLEAH
                     GETSVELAPSDVASLREAAVELREVFAARDAGEAAEVLNRLLARYAHPPRLTDHSDGFG
                     WHLHVDADDDGPWGAWLVTSSALALAVLLADRQAPPGGLCAASGCGRPFAHLGGGSPRR
                     YCSTRCATRERVAAHRRQRS"
     gene            14904..16070
                     /locus_tag="CVV72_RS17730"
                     /old_locus_tag="CVV72_17660"
     CDS             14904..16070
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029315.1"
                     /locus_tag="CVV72_RS17730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17660"
                     /product="MFS transporter"
                     /protein_id="WP_219153421.1"
                     /transl_table=11
                     /translation="MRSRYRLAAYLTGATVARTGDELSGPALLLLGMSFDGSAATGSAL
                     LAGLTISAAAGGPLLGALLDRSPRPGRLLAWALLAYAGGLGAVLALVELPAAIAVAVAA
                     GLLNPALAGGWTAQLPNVRGTTPLARASTLDAMTFTAASLAGPGLAGLVAAYAGAPAAV
                     AVAITLVAAAFPAAWALPGVEAKPSTSIRRQLADGFAVLFRNRALLRATATSTVSFVGI
                     GVAIVCYPLLGAQRLGNPGFGALLLAVLAAASLVANAVLARRPPPPDRTLLASTVLLGA
                     SFVLAASSEGVVPLLAAAVLAGFAEGPQLSALFAIRHREAPARVRAQVFTTAASVKITG
                     LAAGAALAGPLSALSVTTALGVAAGCQLLAAATYVLVGPRTPSPARAA"
     gene            complement(16039..16407)
                     /locus_tag="CVV72_RS17735"
                     /old_locus_tag="CVV72_17665"
     CDS             complement(16039..16407)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657740.1"
                     /locus_tag="CVV72_RS17735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17665"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_219153422.1"
                     /transl_table=11
                     /translation="MSGIPVADDVLDADVAVLPVPEVATALNVSANKVRQMLRDGHLIA
                     VRRKGELYVPAGFLVKDGVVKGLAGTITVLADAGFSRTEMLRWLFAADETLPGTTPVNA
                     LRTSHGTEVKRRAQAMAF"
     misc_feature    16561..16574
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            16593..18647
                     /gene="pknB"
                     /locus_tag="CVV72_RS17740"
                     /old_locus_tag="CVV72_17670"
     CDS             16593..18647
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332682.1"
                     /locus_tag="CVV72_RS17740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17670"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_219153423.1"
                     /sec_met_domain="Pkinase (E-value: 1.7e-46, bitscore:
                     157.6, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTDPTLVGTLLEGRYRVDKLLARGGMSSVYRGVDTRLDRQVAI
                     KIMDPRFADDRSFVERFEREARSAARLHHPHVVAVHDQGFDTPGGEESGRAFLVMELVD
                     GGTLRELLAERGPLDVALALSITEPVLSALAAAHAAGLVHRDVKPENVLIGRGGTALSG
                     GVVKVADFGLVRAIASAGTTSSSVILGTVAYVSPEQVATGATTSRGDVYSAGILLYEML
                     TGRPPYTGDTALSVAYRHVNDDVPRPSELRPGIPPQLDELILRATRRDPEQRPADAAAF
                     LAELHHLRTVLGVPAVPVPVPLPADADRETDAERTTPGIPAVPAANPAMATTVLTPVAE
                     ATMPVTGPRGTQALHREPPIPAAQPPRTPPPRPRPAADDEQPGSRKRLYVMIAAAVLVL
                     GGLIGAFAFILNDTGPSSSSVPKLAGMNQAAAGDALRSAKLTPAYTEEYSDTAAQHTVI
                     RSDPAEGTSLAPGATVNVVLSKGRPIVPDIQAGTSPQDAETAIKAAQLTPVQGEQEYSD
                     VAKNKVIRVDPSPGSQLNIGGQVTIILSKGPEPLPPVPDVTGQTKDAAFQILQQAGFQP
                     FQAGEEFSDQFAAGQVIRTDPKGGGKASNRRIGVFVSNAVEVPNVTFKRMEEAFQILRQ
                     AGLEPDRQGRGNGNGNGGGNGGFDFVLEQDPQPGTKVPKGTKVKLKGFG"
     gene            18778..19563
                     /locus_tag="CVV72_RS17745"
                     /old_locus_tag="CVV72_17675"
     CDS             18778..19563
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029318.1"
                     /locus_tag="CVV72_RS17745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17675"
                     /product="hypothetical protein"
                     /protein_id="WP_219153424.1"
                     /transl_table=11
                     /translation="MSFFTDAPRNRPLFPVPEQELFGYNGRPWVEPPHEYIVPAILPWS
                     MPLGRAERTIVALRGIEVWPESVSFQLSVYSRDLLLDEPGEGLIDHRRVPDYNALLVGV
                     LFPDGRRASSETISVPSATKPDQPVLRAQGLGGSAFHVDHEIFLWPLPPDGPLELIVQW
                     LDRDIEETRTSLDGTAIRDAAKEAGEIWPGLPAREAHGLPVRRVGAQAMITPAWPRESQ
                     SPPPLPQPSAPRPTSPPAEAAAQPRRGAPLPTRLPRRAR"
     gene            complement(19680..20513)
                     /locus_tag="CVV72_RS17750"
                     /old_locus_tag="CVV72_17680"
     CDS             complement(19680..20513)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637674.1"
                     /locus_tag="CVV72_RS17750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17680"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_219153425.1"
                     /transl_table=11
                     /translation="MTILVTGATGSVGRLLVDELVEAGAPVRALTVDPAKAALPEQVEV
                     AKGYLGKPETLPEALKGIETVYLAPLAAKVDDFVKLAKEAGVRRVVALSGSNADDPAEN
                     SSGVDYAIIEKAVREGGFDWTFLRPGAFMNNTLGWAETIKAERVVREAYPESRMTPIDL
                     ADIAAVAAHVILTEGHVGKKHTLSGPEAISQREQVAAISAALGEEVVFHELTREEANKQ
                     WAAAGIPAEIAEWLLDGFAYFTENPDKPTGVVQELTGRPGVTYAEWAVTNVEAFR"
     misc_feature    complement(20531..20548)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            20609..21358
                     /locus_tag="CVV72_RS17755"
                     /old_locus_tag="CVV72_17685"
     CDS             20609..21358
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332679.1"
                     /locus_tag="CVV72_RS17755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17685"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_219153426.1"
                     /transl_table=11
                     /translation="MDFERSLELLWRDRGEARQSTRGRKPKLTLDQVIATAVALADGAG
                     EATVSMSQIAKKLGAGTMTLYTYVPGKTELLDLMVDSVLAERDLPGPGDPRPDGWREQV
                     RLYAERTLAVFRAHPWLRSTSMVRPVLGPGLMAGQEYLIAAVSDIGLEPRKAAAAANSI
                     EIYVQANATLFAETALVEQETGQSTDAWWGQRSVFWEKYFDVERHPAMTRIWESGGYDA
                     DTCEAADETFAFGLERLLDGIEALVTR"
     gene            complement(21430..22248)
                     /locus_tag="CVV72_RS17760"
                     /old_locus_tag="CVV72_17690"
     CDS             complement(21430..22248)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332678.1"
                     /locus_tag="CVV72_RS17760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17690"
                     /product="cell division protein FtsQ/DivIB"
                     /protein_id="WP_219153427.1"
                     /transl_table=11
                     /translation="MPRTGERRRPAEPGRRPRTERAQRTQRLKERRGRRSVYDRRRTAR
                     PSRHKELRRRWVALLSVLTAVALVYLLWFSSMLGVQQVDVVGASSVPADQIRAAAAVPD
                     QKPMLRLDTDEIRDRVAQMPGIATVDVSRSWPSTLEITVTERTAIAFFDSGPGGDGVHL
                     VDGGGVVFKTVKERPAGLPELKLPSVSADDPVTRAVTGVLGVIPQQLLKQVTTATAKTP
                     GSVEFALADGKTVRWGTSADTERKAKVLAALLTREGKVFDVSAPDLPTVS"
     misc_feature    22265..22279
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    22484..22498
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     misc_feature    22715..22729
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    23218..23233
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.97"
                     /tool="antismash"
     misc_feature    complement(23413..23426)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.93"
                     /tool="antismash"
ORIGIN
        1 cggatcgcga tcctggccag ggtgccgggc cggtcgtcca cgcggatccg gacacgccag
       61 gccgacgcgg ccgcggtctc ttcgccgggg tggaccaggg tgggccgggc tcgataggtc
      121 tccatgactc cacggtcccg gccggttgtt gcctgcccac ggcgcggatg tttcgctcac
      181 gtcagcgttc gacgccaccg cgcaaccccg gcgaaacact cagcggggag aaagcacgct
      241 gaattcgttg ccctccggat ccaccatcgc ttcggcacgt tcccccgacg cgcccagctc
      301 ccgcaggcgc cggacctcgg ccgcccggct cttgcctcgc cgtggcgcga tctcgaaccg
      361 cagccggttc ctgtgccgct tctcctcttc cgtggcgagg aactcgaccc agggaccgcg
      421 gccgtccggt ggccgcaggc cgacgatcga ctcctcccgg acgccgatct cccagccgag
      481 ggcggccgcc cagaaccgcg ccagccgctc cgggtcgagg gcgtcggtga cgaccgaggc
      541 gatcgcgccg gtgccctcgt actgctcgcg gggctcgaga acacagaact cgttgccctc
      601 ggggtccgcg agcaccaccc acggcacccg cttctcctcc ggcgcgccct ggccgatgtc
      661 gatgtgccgt gcgccgaggg acagcgcacg atccaccagc ccggcctggt gctcgggcga
      721 acggctcgcc agatccaggt gcagccggtt cttgccccgt ttggggcccg cctcggagcg
      781 gaacgccggt tggaacgggg cgtcccagct gaacagccct tcccagaaac ccgccagatc
      841 tctgggaagg gccgagtcga agaccaggtt caccagctgt accgccacac cggtgaacct
      901 agacggcacc accgacagtt ctgtgcgtct tcggtgaacc cgcgggcgct caggccactc
      961 cagctccctg acactgatga ccggtttggc ttccccaccg accgatcatc gggtcgcgag
     1021 ccgcagaagg gcccagagtt gtcccgccat gtcctggtct ccgctgaccg tcaccgccgt
     1081 cggacccgcc cggccccaga gccagcggta gatcttgtcc ggcttcccgg tgatcaggtc
     1141 gtccgcgcgc tgggcctcct cggccgagca ccgccaggcg accgtctccg tcggccccgc
     1201 cctggcgatc caggtgtggc ccgcggtgcg cacgccgacc gagccggtct tggtgccgga
     1261 gagtcccagc aacggcagcc gctggccgaa ccacagcacc agcgcctcgt cgatcccgtc
     1321 gagtgccacg tcttcgggga tctccgacac ttcccggccg gccgcgctct ccgcgtcgat
     1381 ccggtggatc gtcgtctcgt gcgccgtccg ccgccgccag aacccgtagc tgcggtctgc
     1441 cggccaccag gtcggcgcca gttcgtccgg gtcgtgcgcg gacagttcgg cgacgagctc
     1501 gtcccggccc tcgcggaagt actcctccag gctctgtccc ggccccggtt tgcgctgcca
     1561 gtgctcggga cgccgtccgt cggtgatcca gcggcgggtg acccggtaca cgctgccgac
     1621 gtgcctgagg acttcgccga gcgtccagcc ggggcaggtc gggaccggcg cgtcggcgga
     1681 cgcggtatgc gccacctggg ccatcaactc ggtttcggcg ccgatcacct ccaggaacct
     1741 gccctggtcg atcatggcct gcccggccat cgggcacccc ctctccgcgg cggctctgtg
     1801 catgggtgga ccccgcgtcc gcgatcggcg tcgcagggcg cgggctggtc tttccgggtc
     1861 acgcaggaaa tccgggagcg cgtccgagcg ccaccggctc aggccacatg cgccgagtca
     1921 cccatcggca gcccgtgcac cacccgtcgc accagttcca ggaacaccgt ggcggcccgg
     1981 gtcagctcgt ccgccagttc ggcggtgacc ttgccggtga tgcccgcctg cgcggcggct
     2041 cgcgtcgccg aattggccgc gaagaacgcc gcccattcct tcagctcggg cgcgacggag
     2101 tcgagcagca cccagccgct cgccggccgg gcacggcccc ggtgcggacg gccgcgggcc
     2161 tccagtaccg ccgccgcacc ccgcagcgcg gcgagatacg ccccgatgaa ccgctccgcg
     2221 ggagcactct cccgctctgc ttcggcgagc ccccgcctcg cctgcgcgta caaggagacc
     2281 gccgcgggtg gtgccggcgg gcgcaacgac atcggcaggg cgggctgcgc ggtgcccccc
     2341 ggcctctcgg cttcgtcggg ggacacgacc gaaacggaca tgacgaccct cctcctgtac
     2401 gtgagcgccc gccggtgccc ggcgccgagg cgcttccccc gcccccgcgc cgggcaccta
     2461 ccggtgcgcg ctcaccgaat gtcgaacgtc tgttcgaaca agtccaatgt aaccccgaag
     2521 tgccccattc ctcaaccccg taccggggtg atcgccgcat gtggtgcggg acacggcatc
     2581 ggccacgtga tctcatagac gtatgagcac catcgaccgg tctggtcatc cctcggtggc
     2641 caaggtcgcg gccgcgctcg ccgaggcggg ccagcacgcc gccgccgacg ggatccggat
     2701 cctccccgcc gaaatccgca cggccgcgca ggccgccgaa gcgctcggtg tcgaggtcgg
     2761 cgcgatcgcg aacagcctcg tcttccgcag ccgcaccggc gacgcggaaa cggccctgct
     2821 cgcgttgacc tcgggcgcgc accgtgccga caccgcgctg ctggcctcgg tgaccggagc
     2881 cgacgagatc ggcaaggcgg acgcggattt cgtccgcgcg cacacggggc agccgatcgg
     2941 cggcgtcgcc ccggtcggtc acccgaaggc gttgaccacc ctcgtcgaca ccgcgttacg
     3001 cgcgcacgag gtcgtctggg ccgccgccgg gcatccgaag tcggtgtacc ccacgacgtt
     3061 cgacggcctc gtcgcgctga ccgggggtac tcccgcggac gtcgcgggcg acgggcagga
     3121 tgggcgcccg tgaccgcgat gtcctcggaa tgcacccgtt acgtccagct gtccgcggac
     3181 gagttccgcg cccggctccc cgaggcgctg accatctacg tcaacgccat gcgctacccc
     3241 gaaggcacgg cggagcaacg cgcgccgatg tggctcacgc acgcgctgcg cgaaggctgg
     3301 cgctgcatgg ccgcgctcga cgcggacggc gtcctgctcg ggctcgccta cggctacaag
     3361 ggccgcggcg gccagtggtg gcacgaacag gtccgccacg gcctgacccg gcgtgagggc
     3421 caggccgccg ccgagcactg gatgtccgac tacttcgagc tcaccgagat ccacgtcagc
     3481 cccgaaagcc aggggaagcg gatcggcgag gacctcctgc gacggctgct cgacggcgtg
     3541 cccagcgccc acgtcctcct ttccacaccg gaaggcacca gccgggcctg gaacctgtac
     3601 cggcgggtcg gcttcgtcga cgtgctgcgg gactaccatt tcgccgggga tccgcggccg
     3661 ttcgcgatcc tcggccggac gctgccgctc tagggtttcg agtaggcgac cgtgagcgcg
     3721 gcgatgagca ccaccgcgcc gcaccagccc acgacgccga gccgttcccc gagcagcacc
     3781 atggacagca gcgcggccgt caacggttcg agcagggccg acaacgcggc cagtacggga
     3841 tgcgcgcttt cgagaccgcg gaagtacgcg gcgtacgcca gcgccgtcgg cacgacgccg
     3901 aagtagacga cgagcgcgag cacgtcggct tgaaccggca ccgccatccc gaaccacagc
     3961 gcggcggggg cgagcgcggc gccgccgatc agacagccga aagccgtggt gggcaaggga
     4021 tcgaggcctt cgacacgggt cgcggtcacc agtgtcagcg cggcgaatcc ggccgcggcg
     4081 aggagggcga acagcacccc tgcgacgtcg gcctcctgtc cgggcgtcca ttgcagcaac
     4141 gcgagcccga cgagggagcc ggccacggac accgccgtcc acgctccggg caggcggcgg
     4201 gtcttgacgg ccgtcgcgac ggcgagcagg acgggcgcgc tgccgatggt ggtcatcgtc
     4261 gcgacgctca cggaactcag cgagaccgcg gcgaagtagc tggtctggaa gagggcgaac
     4321 agcccgccga ccgccaggag gcgacggcgg acccgcggag cgcggggaag accgcgaagg
     4381 cctccggtga gccagagata gccggtggcg atcacgccgc cgatgagcag ccggtacgcg
     4441 gcgacgctca ggggatgaag tcccgcacgg gacgcgagca gggatccggc gaggccgccg
     4501 gtcccccaga ggactccggc gaggacgagc gcggccgacg atcgggcgcg cgtgggtacg
     4561 gcaacggaca tggggaaacg ctcctgcgtc tgtgtctgtc ggaaaggacg tcgacgacgc
     4621 ggggtgcttc agtgcagcac ggatcggccg ggcggctgga acgccgcgcg gccggagaca
     4681 ccccgctcag gaggcggggg gtggggtgac gaggaagatc cggtgcacga gggggaacgt
     4741 atcaagactc cggggcggga gcacgggaat tacggcacgc ggaggctccc tccggatgcc
     4801 atgaacggtc cgttactcgc gaatttcgcg agtaacggac cgttcatggc actaccgcgg
     4861 ctcagtccag cgtggccagc atctcccgca gcgtgtccag tcccatcccg ccgagcgcca
     4921 gcgcccgcgt gtggaactgc ttgatgtcga acgcgtcgcc ctgccgctcg cgggcctcct
     4981 cgcgggcggt gagccagagc cgttcgccga gcttgtacga cggcgcctgc ccgggccagc
     5041 ccaggtagcg gtcgatctcg tcgtgcacgt gggccgggtc ggtgacggtc cgggtgagca
     5101 tgaactccag gcccagttcg ggcgtccacc gctcgccctc gtggaagccg gtgcccgccg
     5161 ggatctccag ttccaggtgc atgccgatgt cgacgatcac ccgcgcggcg cggaacagct
     5221 gctcggacag catgccgaac agttcaccgt cgtcggcgag gaacccgagg tcctccatca
     5281 gccgctcgga gtacagcgcc cagccctcgg cgtgcccgga ggtgaacgcc agcagccgct
     5341 ggtacttgtt gagtgactcc gactggtcga ccgcggtcgc gatctgcagg tggtggcccg
     5401 gcgcgccctc gtggtagacg gtgctgacct cgcgccaggt ggtgaactcg tcccggcctt
     5461 gcggcagcga ccaccacatg cggccggggc gggagaagtc ctcgctcggg ccggtgtagt
     5521 acgcgccgac ggtgccgccg ggcggggcga tcttgcactc cagtgccatc acccggtcgg
     5581 agatgtcgaa gtgcttgccg cgcaacgact tcagcgcgtt gtcggacagg ttctgcatcc
     5641 aggcctggaa ttccgcccgg ccgcgcacga cgtacttggg gtcggcgtcg agggcggcgg
     5701 ccgcctcggc gagggtcgcg ccgggtttga tccggccggc gacctcgcgc atctccgtct
     5761 cgatgcgggt gaattcggcc cagccccagg cgtaggcctc gtccaggtcg aaggtggctc
     5821 cggtgaacaa acgggaccac agccggtaga cctcggcgcc gacggcgtcc ttgaccggcg
     5881 ccagcggggc gagttcggcg cggaggaaac cggcgaactc cgcgtacgcc tcctgcgcgg
     5941 cgtgagcggc ctgaccgagc tccgcgcgca gcttgtcgtc gacgtccttc gcccccgcga
     6001 ccagcgtctc gaagaaaccg tcgtcgtcct tcaaccccgc ccaggtttca gcctgttcgg
     6061 cgaccttgcc gacctgtcgc aacgccgaca cccggccggc ggccgcggcc gcgagcagcg
     6121 aggaacggag accgtcgagc gcttcgggca ccctcgccat ccgggcggcg atcgtcgccc
     6181 agtccgccgc ggtgtcggtg ggcatgaagt cgaagaccat gcgcagttcc tgcacggggc
     6241 tttcgatcac gttcagcgct gcgaggtcga gacccgcctc gtggatctcc aggtgcagtc
     6301 cgatccgctc ggtgaacacc gccttggccg cgcgctcgcc gtcgtcggcg ggttcggccg
     6361 ctgagatgtc ggccagcgcg cgggcggcga tggcggcccg tgccgcgtgc ccggcgggcg
     6421 agtagtcggt cagctggtcg tcgtatccgg agatgccgta cgtcgtcgcg gcgaccgggt
     6481 cggccgcggc gtagtcgtcg acgtaccggt cacagatctg gtgcacagtt cgcgcggttg
     6541 aagccatgac cggcacgcta ccgggacggc gggcgacttc ggtacggagt tacgcgcggg
     6601 ccgggaccag ccccagcctg ctgaccacct cacgcgtggc cttggaccgg ttgaacgtgt
     6661 agaagtgcag gtcgggaacg ccttcggcga tgagccgctc gcccagttcg gtcaccgcgt
     6721 cgatccccgc ggcgcggaag gccttggggt cgtcggccag cggttcgagc cggtccagca
     6781 gccgccgcgg cgcgggcgcg ccggacagct tgatggacgt gtgcagggtc cgcggcgtgg
     6841 tcagcggcat gatgccgggg atgaccagcg cctcgcagcc ggtggccgcc acccggtcgc
     6901 gcaggcggag gaagtcctcc ggctcgaaga acagctgcgc gatggcgaaa tccgcgccgg
     6961 cgcggagctt gcgcacgagg tattcggtgt cggcttcgag gttcgccgac cgcgggtggc
     7021 cgtacgggaa ggccgagacg ccgacgcaga agtcgccgag cgaacgcacc agctcgacga
     7081 gttcctcggc gtagttgagt ccctccggat gcgggaccca gtcgccgtag acgtcgcccg
     7141 gcgggtcgcc ccgcagcgcg aggatgttcc gcacgccgac ggcggcgtac cagccgatga
     7201 cgttgcgcag ttccgcgacc gagtggttca cggcggtgag gtgcgccatc ggcaccagcg
     7261 tggtctcggt ggcgacgcgg gcgatgctgc ggatcgtgcc gtcccggctg gagccgccgg
     7321 cgccgtaggt gatcgacatg tacgccgggt ccagcggctc gagttcccgg atcgacttcc
     7381 acaggacggc ctcgtcggcc gcgtcgcggg gcgggaagaa ctcgatggag aacacgggtc
     7441 catcaccctg caaccgctcg accaccgaag tcattccgcc attttaaggg ggaatgtccg
     7501 ctggctggga gccccctctc aggctatggg cgtgcgactt cagccacgta cgagcggttg
     7561 ccgagcggag ccgggctggg gagactcggt gacgagcaca gggagccgcc atgagcgccg
     7621 aaaccgacac cagctgggac gaggacgtcc gcgtcgcggt ctaccgcgcg ttcgccgagc
     7681 acgggaggcc gccgacggcc ccggaactgg ccgacgccgc ccatggatca ctcgcggtgg
     7741 cgaagcaggc gctgcaccgg ctcgccgagc ggcggcatct cgtgctcgac gaatgcgagc
     7801 acgtcgtgct ggcgcatccg ttcgcggcga tcccgctggg gttctccgtg atgggcgcgc
     7861 acacgctgtg gtggggtggc tgcgcgtggg acgccttcgc gatcccgcat ctggtcaagg
     7921 ccgaacccga ggtactggtg tccacgcgct gccggggctg cggcgagccg cacgccctgc
     7981 tggtgaacga ccgcacccca ccgaagggtg aactggtcgc gcacttcctg gtgcccgtgg
     8041 cgcggatgtg ggacgacgtc gtgtacacct gcggcaacca gcgcctgttc tgtggtgagt
     8101 cctgtgtgga cggatggctg acggaaacgg ggcaggacaa gggttatgtc atggacctgg
     8161 cgacgctgtg gcggctcgcc gcaggctggt acgagggcag gctcgaacac gggtacgtcc
     8221 gccgggatcc ggccgccgcg gccgcgtact tcggccgggc cggggtgagc ggcccgttct
     8281 ggaactagac caggaaccgc ggcggaaagg cacccccaag ggcgtgtcgc gacgtcccgg
     8341 cacgtacgcc cgcccgctag accaggaacc ggagcgccgc cgtgacgacg accccgcaga
     8401 ggatcgcggc gagcaccggc acgcgcagcg cgtaggtcac cgcgatcgcg gcaaggccgg
     8461 cacaaagcgt ccattcgagc ccggaccagg ccgggcctgc cacgtccgtg agcacgagac
     8521 ccgccagcaa cgcgggcgcg agcagcgcga tcacgcctgc gagccgaggc ggcagcgtcc
     8581 ggtcgccgag caggaccggg cccgccgctt tgaacccgat gctgaccagc gcgacgagga
     8641 cgatggcgag ccagagcgtc atcggcgcgc ccccaccccg agcagcgccg cggcggaggc
     8701 gccgatcagc gcgagcccga ccgggacgaa cagcaccagg atccccgcca gacaggcggc
     8761 gagggccgcg gtcaggaccg cctggcgcga gcggcgcagt tcgtcgatga gcaggaccag
     8821 gaagaagccc gggaacacga cgtcgagccc gaaccgcgag acgacgtccg gtggtggcgc
     8881 ggccagaacg cccagcaccg tccccagtat ccatgcgggc agctggacga gcgtgcagcc
     8941 gatgagcttc tcgcggtcga agcgcccttc gccgaggtgg gcggccaccc aggaaccgtc
     9001 gacgacggcc tggccttccc acgcgcgccg cagccgcccg ccgcgcaggt ccgcggcgac
     9061 ggcggcgccc atcggcagga accgggcgtt gatcagggcc gcggcgccca ccgcgacggc
     9121 gaggttgccg ccgcccgcga gcgcggtggc catcgcgaac tgggccgatc cggagaacac
     9181 gaggatcgac gcgacgatcg gggcggcgat cccccagccc agcgtctggc tgtacgcgcc
     9241 gaaggtgaca ccgagaacga aggtcgcgac acccagcccg agcccgacac gggcgccggc
     9301 caggtaactg tgccggcgcg tcgatatctc cgtcatagct cgaccctaac aagctaaact
     9361 cactttgacc attaggagaa gtcatggacg gccattggga cgggtacgac agcatcggcg
     9421 ggagtgtgcc gttggacctg gtcaacaccg tttcctggcg acgcgatccg gcccggcggg
     9481 acgaccggct ttcgactccg gaacgactct ccgagtgggt ggtcctggtc ggcgcgggca
     9541 ccgaacggct ggagatctcc gaagccgtcc tggagacggt gaaggccttc cgcgagacgc
     9601 tgtaccgcgt actcgtgtcg gatccaccgg acgtcacggc cctgcggaag cccctgatcg
     9661 aggcgtaccg gcacgcctca ctcccgccgt ccttgccact gcgctgggag gtgccgctgg
     9721 aaaacggcga cgcgctgccg cacttcctcg cgctggcggc cgagaacctg ctccggaccg
     9781 ggaatccgga gcggatccgg gagtgcgaag ggcccggctg cggctgggtc ttcaccgacc
     9841 acacgcgcaa ccggtcgcgg cgctggtgca gttcgtcgga ctgcggcaac cgggcgcggg
     9901 tgaaacggca ctacgacaag acccgcggtt gacgtctcgt tcgccacatt ccacggcacc
     9961 cgactgggtc atggggacgc gcttcccgga ggatgtgctc atggacacgt ccgcctacga
    10021 cgccgatctg cccgcccacg tcgagcgggc gctggccgga ttcctcgagc gcgccggtgc
    10081 cgagatccgc cgtaccgaac cggtcgtcgg ggtcgggatc gacgcgctgg ccgggttcgt
    10141 cctcggcggt ggcaaacgcc tgcgcccgac gttcgcctgg tggggctggc gcggcgcggg
    10201 cggcgatccg gcggggccgg acgtcgaagg cgtgctgcag gcggtggcca gcctggagct
    10261 gatccaggcg tgcgcgctga tccacgacga cctcatcgac tcctccgatt cacggcgcgg
    10321 ctccccgacg gtgcacatcg cgggcgccaa actgcacgcc gacagcggct ggctgggttc
    10381 gccgagcacg ttcgggctcg cgaccgccgt cctggtcggc gacctcgcgc tggcctgggc
    10441 cgacgacatg ttcggcgagg ccccgctccc gcccgcggcc ctcgcggcgg cgcggccggc
    10501 ctggcgcgcg atgcgcaccg aggtgctcgc cggccagtac ctcgacgtcc gcacccaggc
    10561 caccggcgac gcttcccccg aggcggcgct gcacatctgc aagctcaaga cggccgcgta
    10621 caccgtccag cgcccgctgc acctcggtgc cgcgctcggc ggcgccgacg acgccctgat
    10681 cgcgacgctg cgcgaattcg gcgacgaggt cggcgtggcg ttccagctgc gggacgacct
    10741 gctcggggtg ttcggcgacc catcggtcac cggcaagccc gcgggcgacg acctgcgtga
    10801 gggcaagcgg acgctgctgg tcgcgctggg tctccagcgc gcggccgagc agggcaagga
    10861 cgcggcggcg aaggtcatct ccgacgccat cggcgacgcc cacctgtccg aagacgccgt
    10921 cgagactgtc cgtgaggcgt tgcaggacgt cggcgcggtc gacgcggtgg aacgccgcat
    10981 cgacgagctc accgattccg cgatggcggc gctggaccgc gctcacctgg ccgaacccgc
    11041 tcccgccgcg ctgaccgggc tggtcgtcaa ggcgacccag cggacgtact gatgcgcact
    11101 gtcaccggtc cgagtgacca cgtggtggtg atcggtggcg ggctcgccgg gttgtcggcg
    11161 acgctgcatc tgctcggcgc cggccgccgg gtgacgctgc tggagcagga caagagcccg
    11221 ggaggccggg ccgggcaggc ggatatcggc ggcaacaccg tcgacaccgg cgccagcgtg
    11281 ctgaccatgc cggaactgct cgacgaggcc tttgccgcgg tcggcgaatc cctggcggac
    11341 aatctcacgc tgacccggct cgatccggcc taccgcgcga ggttcgccga cggcagcacg
    11401 atcgccgtgc acaccgaggc ggcggcgatg gaggccgaga tccgcgcggc cgcgggaccg
    11461 gccgaagccg acggctaccg caggcttcgc cagtggctga ccgagctgta cacggtccag
    11521 aaagaccact tcatcggcgc gaacttcgat tccccgctcg atctcgtccg cccggaactg
    11581 gcgaaattgg ccgcactggg cggtttcggc cgcctcggcc cgaagatcgg ccggttcctc
    11641 cgtgacgacc gggttcgccg cctgttctcc ttccaggcgc tttacgcggg cctcgatccg
    11701 gcgcgcgcga tcggcgcgta cggcgtcatc tcctacatgg acaccgtcgg cggcgtctac
    11761 tacccctcgg gcgggatggg cgagatcgcg cgagccatgg cgaacgccgc cgaacgcgcc
    11821 ggcgcggaac tgcggttcgg caccgaagcc gcttggctgg aaagggtttc ctcgcgggtg
    11881 cgcgcggtgc ggacccgaac cggtgagcgg atcccttgcg acacggtggt tctggcgacc
    11941 gaactcggca ccgcgtaccg gctgctcggc gcccgccccc ggcggccgct gccgctgcgg
    12001 tactcgccgt cggccgtcgt cctgcacggg aacgcgccga aatcctggcc ggatctgggc
    12061 caccacacca tcttcttcgg tcacgcctgg gagcggacgt tctcggagat catccgcgag
    12121 ggcaagctga tgagcgaccc ttcgctgctg gtgacccggc cgaccgcgac cgaaccgggc
    12181 ctctcccccg gcggcggcca ggtgatctcg gtgctggccc cggcgccgaa cctgcgccgc
    12241 ggcaagatcg actggcgccg ggtcgggccc gtctatcgca cggaactggt gtgcacactg
    12301 gaaaagcgcg gcctcgccgg gttcgcggac ggcttctccg tcgacgagac gatcaccccg
    12361 gaaggctggg cggagcgcgg tctcaccgcc ggcacgccgt tctcgctcgc gcacaccttc
    12421 gcccagaccg gcccgttccg gccggggaat ctcctgcggg cagcggaaaa cgtcgtactg
    12481 gcgggctgcg ggaccacacc gggcgtcggc atcccgccgg tggtgatctc cggcaggctc
    12541 gcggcgggaa ggatcaccgg ccgatgaacg agctcgacgc cgccgggatc accgagccgt
    12601 cgttgcgggc cgcgtacacc gaatgccgcc ggatcaacgc gcactacggc cgcaccttct
    12661 tcctcgcgac ccggctgctg ccggcacgga cgcggccgta cgcgcacgcg ctgtacggct
    12721 tcgcgcggat ggcggacgaa gtggtcgaca accccgcgcc cggcaccgat cccgcggtcg
    12781 cgctggacga ggtcgccgcc atggtcacgc aggtcttcga cggcggcacg cccgccgatc
    12841 cggtgctgac cgcgctcgcc gacaccgtgc ggcgccacga tctggaccgc gaattgttcg
    12901 acgcgttcct gcggtccatg acgatggacc tcaagatcac cgcgtacgcg acctatgccg
    12961 acctccggga gtacatccac ggttcggccg aggtgatcgg cctgcagatg ctgcccgtct
    13021 tcggcaccgt cgtcccggtc gccgaagccg tgccgggcgc cgccgcgctg ggtgaggcgt
    13081 tccagctgac caacttcctg cgcgatgtcg gcgaggacct cgatcgggga aggctgtacc
    13141 tgccgaccga ggagctggcc gcgttcggcg tcgaccgcga actgctcgaa tggtcccgtg
    13201 cccgcgggct gcccgaccgg cgggtgcggc gcgcgctcgc cgtcgcggtg gcgcgcaacc
    13261 gggcggtgta ccgccgtgcc gaagcgggca ttccgttgct gcgcccggaa tcccgggcct
    13321 gcgtgcggac cgcgctcgtg ctctacgaag gcattctcga cgaaatcacg gccctgggtc
    13381 acgacgtgct gaacacccgc gcggtcgtcc cgcgccgtcg ccggctggga gtcgcgcttc
    13441 cgaggttttt ggcgagcgcg tggagcaact ccaggcttag ggtgcgaaca tgaccactgc
    13501 tgagaacagg aagatccgga tcggcgtcca gctgcagccc cagcacgccg agtacaaggc
    13561 gatccgccgg gcggcttcgg aggccgaaga cctcggtgtg gacatcgtct tcaactggga
    13621 ccacttctac ccgctctacg gtgagcccga aggcctgcac tacgagtgct ggaccatgct
    13681 gggcgcctgg gcggagtcca cgtcgcgggt cgaaatcggc gcgctggtga cgtgcaacag
    13741 ctaccgcaac cccgaactgc tggccgacat ggcccgcacc gtcgacaaca tctccgacgg
    13801 gcggctgatc ctcggcatcg gctccggctg gttcgagaag gactacgacg agtacggcta
    13861 cgagttcggc accgcgggcg ggcggctcga caacctcgcc gaggcgctcc cgcggatcga
    13921 gagcaggctg ggcaagctga acccgcagcc ggtccgggac atcccggtgc tgatcggtgg
    13981 cggcggcgag aagaagaccc tgcgcctggt cgcgaagcac gccgacatct ggcacggctt
    14041 cggcgacccg gaggtcgtgg agcgcaaggt caagatcctc gaccagcact gcgccgacgt
    14101 cggccgcgac ccgaaggaga tcgagcgttc ggtcgccgtc gagggcgagc ccgaggagct
    14161 gggcccgaag ctgctggagc tgggtgtctc gctgttcacc gtggcgaccg gcgggccgga
    14221 ctacaacctc gacaagctgc ggtcctggat cgcctggcgg gacaagcagc agtcctgacc
    14281 cgctctgggt ctcgtgagtg gtaaggacgg ttaaaaccgt ccttaccact cacgagcgtt
    14341 gtcgccggtg agccgcgacc cgctcccggg tggcgcaccg cgtcgagcag taccgccgcg
    14401 ggctcccccc gcccaagtgc gcgaacggcc tcccgcagcc cgaagccgca cacaatccgc
    14461 ccggcggcgc ctgacggtcc gccagcaaca cggccagcgc cagcgcggac gacgtcacca
    14521 gccaagcgcc ccacggcccg tcgtcgtcgg cgtccacgtg gagatgccag ccgaacccgt
    14581 cggagtgatc ggtcagccgc ggcggatgcg cgtaacgagc cagcagccgg ttgagcacct
    14641 ctgccgcctc cccggcatcc cgcgccgcga acacttcccg cagttcgacg gccgcctccc
    14701 gcaacgaggc cacgtccgac ggcgccagct cgaccgaggt ttcgccgtgc gcttccagca
    14761 ccgcgcgaac cgacgcgacc gagggttccg gcgcgagcag gacctccagc agatccaccg
    14821 cccgctggcc cgccgcccga gccgatcggc cgggcaggaa atcccgctgc gctgaagcca
    14881 tagcccactg taacgtctca ttcatgagga gccgttacag actcgccgcc tatttgaccg
    14941 gcgcgacggt cgccaggacc ggggacgaac tgtccggacc ggcgttgctc ctgctcggca
    15001 tgagcttcga cggctcggcc gccaccggat ccgcgctgct cgcgggcctg acgatctccg
    15061 cggcggcggg cgggccgctg ctgggggccc tgctcgaccg cagcccccgg ccggggcggc
    15121 tgctggcgtg ggcactgctc gcctacgcgg gcgggctcgg cgcggtgctc gcactggtcg
    15181 agctccccgc ggcgatcgcc gtggccgtcg cggccgggct gctcaacccc gccttggcgg
    15241 gcggctggac ggcgcaactg ccgaacgtcc gcggcacgac accactggcc agggcgagca
    15301 ccctggacgc gatgacgttc accgccgcga gcctcgccgg gccgggactc gccggcctcg
    15361 tggccgcgta cgccggagca ccggcggcgg tggcggtcgc gatcacgctg gtcgccgcgg
    15421 ccttcccggc cgcgtgggcg cttcccgggg tcgaggcgaa gccctcgaca tcgatccgcc
    15481 gtcaactcgc cgacgggttc gcggtcctct tccgcaaccg cgccctgctg cgagccaccg
    15541 cgacgtccac ggtgtccttc gtcggcatcg gagtcgccat cgtctgttat ccgctgctcg
    15601 gcgcccaacg gctggggaac cctggcttcg gcgcactgct gctcgccgtg ctggccgccg
    15661 cgtcactggt cgcgaacgcc gtactggccc gcaggccacc gccgccggac cgcaccttgc
    15721 tcgccagcac ggtcctgctg ggcgcgagct tcgtgctggc ggcgtcgagc gagggcgtgg
    15781 tgcccctgct ggccgccgcc gtgctcgccg gattcgccga agggccgcag ctttcggcgc
    15841 tgttcgccat ccggcatcgc gaagcgcccg cgcgagtgcg ggctcaggtg ttcacgacgg
    15901 ccgcgagcgt gaagatcacc ggactcgcgg cgggcgccgc gctcgcggga ccgctgagcg
    15961 cactctccgt aaccaccgcg ctgggcgtcg cggcgggctg ccagctcctc gcggccgcga
    16021 cgtatgtgct ggtcggccct agaacgccat cgcctgcgcg cgccgcttga cctcggtgcc
    16081 gtggctcgtg cggagcgcgt tgaccggggt ggtccccggc agggtctcgt ccgcggcgaa
    16141 gagccagcgc agcatctccg tccggctgaa accggcgtcc gcgagcacgg tgatggtgcc
    16201 cgccaagccc ttgaccacgc cgtccttgac caggaacccg gccgggacgt acagctcgcc
    16261 cttccgccgg acggcgatca ggtggccgtc gcgcagcatc tggcggacct tgttggccga
    16321 gacgttcagc gcggtcgcga cctccggaac cgggagaacg gcaacatctg catcgagaac
    16381 gtcgtcggcg acgggaatac cactcacagg tgacactgtg ccacattccg tctcccgctc
    16441 cgttagtacg catgggtgac gacccgggcg atgacggaga gtgcccggtc ggtcacgtat
    16501 accgccgatt cgacgaaatg acgggaatcg tgatccccgg ggagccaggt cccgtacacc
    16561 agaacatggg tacttccgta cgatccatag ccgtgacacg cacggatccc actctggtgg
    16621 gcactctgct cgagggccgc taccgggtgg acaagctgct cgcacgcggt gggatgtcgt
    16681 cggtgtaccg cggcgtcgac acccgcctgg accgccaggt cgccatcaag atcatggacc
    16741 cgcggttcgc cgacgacagg tcgttcgtcg agcgtttcga gcgggaggcc aggtcggcgg
    16801 cccggctgca tcatccgcac gtggtggcgg tgcacgacca gggtttcgac acccccggcg
    16861 gcgaggagtc cggccgcgct ttcctggtca tggaactcgt cgacggcgga accctgcgtg
    16921 aactgctcgc cgaacgcggt cccctggacg tcgcgctcgc gctgagcatc accgaaccgg
    16981 tgctctccgc gctggccgcg gcgcatgccg ccggcctggt gcaccgcgac gtcaaaccgg
    17041 agaacgtgct catcggccgc ggcggcacgg cgctttcggg cggcgtggtc aaggtggcgg
    17101 acttcggcct ggtccgcgcg atcgccagcg cgggtaccac gagttcgagc gtcatcctcg
    17161 gcaccgtcgc ctacgtgtcc cccgaacagg tcgcgaccgg cgcgaccacc tcgcgcggtg
    17221 acgtctactc ggccgggatc ctgctgtacg aaatgctcac cggacgcccg ccgtacaccg
    17281 gcgacaccgc gctctcggtg gcgtaccggc acgtcaacga cgacgtcccg cgcccgagcg
    17341 agctccggcc gggcatcccg ccgcagctgg acgagctgat cctgcgcgcc acgcgccgcg
    17401 accccgagca gcgtccggcc gacgccgcgg ctttcctcgc cgagctgcac catctgcgca
    17461 ccgtcctggg tgtcccggcc gtcccggtgc ccgtgccgtt gcccgccgac gccgatcggg
    17521 agaccgacgc cgagcgcacc acccccggca tccccgccgt cccggcggcg aacccggcca
    17581 tggcgacgac ggtgctgacc ccggtcgccg aagcgaccat gccggtcacc ggcccgcgcg
    17641 gaacgcaggc actgcaccgt gagccgccga tccccgccgc ccagccgccc cgcacgcctc
    17701 ccccgcggcc ccggccggcc gccgacgacg agcagccggg gtcgcgcaag cgcctctacg
    17761 tcatgatcgc cgccgcggtg ctggttctcg gcggcctgat cggcgcgttc gccttcatcc
    17821 tcaacgacac cgggccgagc tcgtcgtcgg tgccgaaact ggcggggatg aaccaggccg
    17881 ccgccgggga cgcgctccgc tcggcgaagc tgaccccggc ctacaccgag gagtacagcg
    17941 acaccgccgc ccagcacacg gtgatccggt ccgaccccgc ggagggcacg tcgctcgcgc
    18001 cgggcgccac ggtcaacgtc gtgctgtcga agggccgccc gatcgtgccg gacatccagg
    18061 ccgggacgag cccgcaggac gcggagacgg cgatcaaggc cgcgcagctg accccggtcc
    18121 agggcgagca ggagtacagc gacgtcgcca agaacaaggt gatccgcgtc gacccgagcc
    18181 ccggttcgca gctgaacatc ggcgggcagg tcacgatcat cctgtcgaag ggccccgagc
    18241 cgctgccgcc ggtcccggac gtcaccgggc agaccaagga cgccgcgttc cagatcctgc
    18301 agcaggcggg tttccagccc ttccaggcgg gcgaggagtt ctccgaccag ttcgccgccg
    18361 gtcaggtgat ccgcaccgac ccgaagggcg gcggcaaggc gagcaaccgc cgcatcgggg
    18421 tgttcgtttc gaacgccgtc gaagtaccga acgtgacgtt caagcggatg gaggaggcgt
    18481 tccagatcct gcggcaggcg gggctggagc ccgaccgtca gggacgcgga aacggcaacg
    18541 ggaacggcgg cggaaacggc ggtttcgact tcgtcctgga gcaggatccg cagccgggca
    18601 ccaaggtgcc gaaggggacg aaagtgaagc tcaagggctt cgggtgacgc gaaaggtgcg
    18661 gtgaaaccgt tcagtaccgg cgtggtcatc ggttaccgtg aaccgcatgg tggtcgttga
    18721 cggcgtgagc ggcaggtcgg acagcttcac cccgcgttct gccgcgcccg gtccacgatg
    18781 agcttcttca cggacgctcc gcgcaaccgc cccctgttcc cggtgccgga acaggaactg
    18841 ttcggctaca acggccgccc ctgggtggag ccgccgcacg agtacatcgt cccggcgatc
    18901 ctgccctggt cgatgccgct gggccgcgcc gaacggacca tcgtggcgct gcgcggtatc
    18961 gaggtgtggc cggagtcggt gtcgttccag ctgtcggtgt actcgcgtga tctgctgctg
    19021 gacgaacccg gcgagggcct catcgaccat cgccgggtcc cggactacaa cgcgctgctg
    19081 gtcggcgtgc tcttccccga tggcaggcgc gccagttcgg agaccatctc cgtgccgtcg
    19141 gccaccaaac cggatcagcc ggtgctgcgc gcgcaggggc tgggcggttc ggcgttccac
    19201 gtcgaccacg agatcttcct gtggccgctg ccgccagacg ggccgctgga gctcatcgtc
    19261 cagtggctcg accgcgacat cgaggagacc cgcacctccc tggacggcac cgcgatccgc
    19321 gacgccgcca aggaggcggg cgagatctgg cccggcctgc ccgcgcgcga ggcgcacggg
    19381 ctgccggtcc gccgggtcgg ggcgcaggcg atgatcaccc cggcctggcc ccgcgaatcg
    19441 cagtccccgc cgcccttgcc gcaaccgtcc gcgcctcggc cgacctcccc gcccgccgag
    19501 gctgccgctc agccgcgacg cggtgcgccg ctgccgaccc gcctcccccg ccgggcccgc
    19561 tgagggcggc aactcgtatc tcgcgtgatc ctggccgtat ctcgcgtgat tgaagccgta
    19621 actcacgagt tacgccttca atcacgtgag ttacggcttc aagcacgtga gttacgagtt
    19681 cagcggaacg cttcgacgtt cgtcaccgcc cactccgcgt aggtgacgcc aggccgtccg
    19741 gtgagctcct ggacgacacc cgtcggcttg tcggggtttt cggtgaagta cgcgaagccg
    19801 tcgaggagcc attcggcgat ctccgccggg atgccggcgg cggcccactg cttgttcgcc
    19861 tcttcccggg tcagctcgtg gaagaccacc tcttcgccga gcgcggccga gatggcggcg
    19921 acctgttcgc gctggctgat cgcctccgga ccgctcagcg tgtgcttctt gccgacgtgc
    19981 ccctcggtca ggatgacgtg cgccgcgacg gcggcgatgt ccgcgaggtc gatcggcgtc
    20041 atccgcgact cggggtaggc ctcgcggacc acgcgctcgg ccttgatcgt ctcggcccag
    20101 ccgagggtgt tgttcatgaa cgcgcccggc cgcaggaacg tccagtcgaa gcctccctcc
    20161 cggacggcct tctcgatgat cgcgtagtcc acgccgctcg agttctccgc cgggtcgtcg
    20221 gcgttgctgc ccgacagcgc gaccaccctg cgcacgccgg cctccttcgc cagcttcacg
    20281 aagtcgtcca ccttggccgc gagcggcgcc aggtacacgg tctcgatgcc tttcagggct
    20341 tccggcaagg tctccggttt gcccaggtac cccttggcga cctccacctg ttcgggcaac
    20401 gcggccttcg ccggatcgac ggtcagcgcc cgcaccggcg ccccggcctc caccagctcg
    20461 tcgacgagca gcctgccgac gcttccggtc gcaccggtca ccaggatcgt cacgattccc
    20521 cactcctttt cgtacgccct acgggataga cttaaccgta ccgcatacga gaatgtagaa
    20581 tccagcttca cggccgagtg gagtgtggat ggacttcgag cgcagcctcg aactgttgtg
    20641 gcgtgaccgc ggcgaagccc ggcagtcgac cagggggcgg aagccgaaac tgaccctcga
    20701 ccaggtgatc gccaccgccg tcgcgctcgc cgacggcgcg ggcgaggcga ccgtgtcgat
    20761 gagccagatc gccaagaagc tcggcgccgg cacgatgacg ctctacacct acgtcccggg
    20821 caagacggaa ctgctcgacc tcatggtgga ctcggtgctc gccgaacggg acctccccgg
    20881 ccccggcgat ccgcggccgg acggctggcg cgagcaggtg cggctctacg ccgagcgcac
    20941 cctggccgtg ttccgcgcgc atccgtggct gcgttcgacg tcgatggtgc ggccggtgct
    21001 cggccccggg ctgatggcgg gccaggagta cctgatcgcg gcggtgtcgg acatcgggct
    21061 ggagccgcgc aaggcggccg cggccgcgaa cagcatcgag atctacgtac aggcgaacgc
    21121 gacgctgttc gccgaaaccg cgctggtcga acaggagacc gggcagtcga ccgacgcctg
    21181 gtgggggcag cggtcggtgt tctgggagaa gtacttcgac gtggagcgcc atccggcgat
    21241 gacgcggatc tgggaaagcg gcggttacga cgcggacacc tgcgaggccg ccgacgagac
    21301 cttcgcgttc ggcctggagc gcctgctgga cggcatcgaa gccctcgtca cccgctgacc
    21361 accccgcgat tcgtcacctg cttgcggtag ttcttagcgc gaactaccgc aagcaggtga
    21421 cgaatcgcgt caggagacgg tgggcagatc cggggccgag acgtcgaaga ccttgccctc
    21481 gcgggtgagc agcgcggcca ggaccttcgc cttgcgttcg gtgtcggccg acgtccccca
    21541 ccgcaccgtc ttcccgtcgg ccagcgcgaa ctcgacgctg cccggggtct tcgccgtcgc
    21601 ggtggtgacc tgcttgagca gctgttgcgg gatcacgccg aggacgccgg tcaccgcgcg
    21661 ggtcaccgga tcgtcggccg acaccgacgg cagcttcagc tcgggcagcc cggcgggccg
    21721 ctccttgacg gtcttgaaca ccactccccc gccgtcgacg aggtgcacgc cgtcgccgcc
    21781 gggcccgctg tcgaagaacg cgatcgcggt ccgttcggtc acggtgatct cgagggtgct
    21841 cggccaggac cgcgagacgt cgacggtcgc gataccgggc atctgcgcca cccggtcgcg
    21901 gatctcgtcg gtgtccaggc gcagcatcgg tttctggtcc ggcaccgccg ccgcggcgcg
    21961 gatctggtcc gcgggcacgg agctcgcccc gacgacgtct acctgctgca cgcccagcat
    22021 cgagctgaac cacagcaggt agaccagcgc gacggcggtc agcaccgaga gcagcgcgac
    22081 ccagcgccgt cgcagctcct tgtggcggct cggccgggcg gtgcggcggc ggtcgtacac
    22141 cgaccgcctg ccacgccgtt ccttcaagcg ttgagtccgc tgagcgcgtt cggtgcgcgg
    22201 acgccgaccg ggttcggccg ggcggcggcg ttccccggtc cgcggcatgg ctaccccgcc
    22261 cgccggtcca gttcggccag gatctccggg ccgagctgcg tgacgtcgcc ggcgcccatg
    22321 gtcaccagca gatcgccggg cttgaccaga tccgccgcga gcttcgccgc gacgtcgaac
    22381 gcgggctggt agtgcacggg gacaccggag atctggtcgg cgatgagcgc accgctcacc
    22441 ccgggctccg gcttctcacg cgccccgaag acgtccagca cgacgacctc gtcggccagt
    22501 gacagcgcgg ccgcgaactc cttcgagaac gtcttcgtcc gcgagtacag atgcggctgg
    22561 aagaccacga tgacccggcc cgggcctgcg gccgtccgca ccgcgcgcag ctgcgcgtcg
    22621 acctcggtcg ggtggtgcgc gtagtcgtcg tacacgcgga cgtcgcccga gcggcccttg
    22681 aactcgaacc gccgccggac gccgccgaac gcggcgagcc cttcggccag tccttcgacg
    22741 ggcgcgccga gctcgatccc ggccagcagc gcggcgatcg cgttcagcgc catgtgctcg
    22801 cccggcaccg ccacccgcag gacgatttcc tcgccctgca aggagatccg gacgacaccg
    22861 ccatccggcg cgggggcgta gtcgagcacc ttggcgtcgt ctgcgccggt gaccgaacgc
    22921 ccatagcggc ggacacggat gccctgcgcc gacgcccgcg cgcccagctc cgaggcgccc
    22981 tcgtcgtcac cgcagacgat gagcagcccg cccggcacga tccggccgag gaagtcggtg
    23041 aacaccgaga cgtacgcctc ggccgtgccg tggtggtcca ggtggtccgg ctcgacgttg
    23101 gtcaccacgg cgaccgacgg cgagtaggcc aggaacgatc cgtcgctctc gtcggcctcg
    23161 gcgacgaaga tcccgccctc gccgtggtgc gcgttggcac ccgactcgtt gaggtcaccg
    23221 ccgatggcga acgacgggtc gagacggcac tgctgcagcg cgacggtcag catcgacgtc
    23281 gtcgacgtct tgccgtgcgt cccggcgatg cacgcgacgc ggtgcccctc catcagcccg
    23341 gccagcgcct cggcgcggtg cagcacggtg atcccgcgtt cccgcgcggc cgccagctcc
    23401 gggttgtcgt ccttgatcgc ggtcgacacg atcaccgagg acgggccttc ggggaacgcg
    23461 tcgaggttct cggcgcgctg gccgacggcg atc
//
