LOCUS       NZ_CP024972            22527 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3859175
            Orig. end                         :: 3881702
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22527
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="22"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22527
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22527
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12527](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12527)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    556..566
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     gene            complement(563..1348)
                     /locus_tag="CVV72_RS17215"
                     /old_locus_tag="CVV72_17145"
     CDS             complement(563..1348)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332768.1"
                     /locus_tag="CVV72_RS17215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17145"
                     /product="ABC transporter permease"
                     /protein_id="WP_091597335.1"
                     /transl_table=11
                     /translation="MNASVSVPGTGALIQVGRLATLSWEVLRAIFKRPFQFREWIQQCW
                     FFASVTILPTALVAIPFGAVIALQLGSLTQQIGAQSFTGAASALAIVQQASPLITALLV
                     AGAGGSAVCADIGARKIREEIDAMEVLGVNPIQRLIVPRVLAAIVVSVLLNGLVSVVGV
                     LGGYFFNVVMQGGTPGAYLASFNALAQVPDLWISEIKALLYGFVAGVVAAFRGLNPAGG
                     PKGVGDAVNQAVVITFLLLFLINVVLTAIYLRIVPPKAM"
     misc_feature    1483..1496
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.61"
                     /tool="antismash"
     gene            complement(1493..2254)
                     /locus_tag="CVV72_RS17220"
                     /old_locus_tag="CVV72_17150"
     CDS             complement(1493..2254)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (7-157). E-value: 7.1e-11. Score:
                     34.3. Matches aSDomain:
                     nrpspksdomains_CVV72_RS17220_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033754.1"
                     /locus_tag="CVV72_RS17220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17150"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_219153343.1"
                     /sec_met_domain="adh_short (E-value: 4.7e-32, bitscore:
                     110.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLDGKVALITGGARGQGEAAARLFVAEGARVVIADINDLDGKK
                     LAAELGESAVYQHLDVGDEAEWDAAIERTVSEFGPPTVLVNNAGILHFSELGKTTLADY
                     ERVIRVNQIGAFLGMRSVVEPMTGAGGGSIVNVSSVEGLAGMPFLVAYTASKFAIRGMT
                     KVAALELGAKNIRVNSVHPGAIDTPMVAAAAGGQKVDMSWVGKKVALGRVGQPEDIAKL
                     VLFLASDESSYSTGSEFVADGGACATHALRF"
     aSDomain        complement(1784..2233)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS17220_PKS_KR.1"
                     /evalue="7.10E-11"
                     /label="CVV72_RS17220_PKS_KR.1"
                     /locus_tag="CVV72_RS17220"
                     /protein_end="157"
                     /protein_start="7"
                     /score="34.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALITGGARGQGEAAARLFVAEGARVVIADINDLDGKKLAAELGE
                     SAVYQHLDVGDEAEWDAAIERTVSEFGPPTVLVNNAGILHFSELGKTTLADYERVIRVN
                     QIGAFLGMRSVVEPMTGAGGGSIVNVSSVEGLAGMPFLVAYTASKF"
     CDS_motif       complement(2150..2227)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CVV72_RS17220_0001"
                     /evalue="4.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="CVV72_RS17220"
                     /protein_end="35"
                     /protein_start="9"
                     /score="12.8"
                     /tool="antismash"
                     /translation="LITGGARGQGEAAARLFVAEGARVVI"
     gene            complement(2271..3155)
                     /locus_tag="CVV72_RS17225"
                     /old_locus_tag="CVV72_17155"
     CDS             complement(2271..3155)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-177). E-value: 2.3e-14. Score:
                     45.6. Matches aSDomain:
                     nrpspksdomains_CVV72_RS17225_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164608.1"
                     /locus_tag="CVV72_RS17225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17155"
                     /product="3-oxoacyl-ACP reductase"
                     /protein_id="WP_219153344.1"
                     /sec_met_domain="adh_short (E-value: 9.9e-32, bitscore:
                     109.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLDGRTAIVTGAGAGLGRAEALALAAAGASVVVNDVSAAARAVA
                     DEIEAEGGKAIAVTGDVSESATADALLTAAVDHFGGLHLLVNNAGVLRDRMLFSMTDDE
                     WDTVLRVHLRGHFLLSRNAGAYWRDKSKVDGAPVYGRVVNTASESFLLGAPGQPNYGAA
                     KAGIAALTVSAARGLSRYGVRANAICPRARTAMTEAVFGADAPEGIDPLSVDHVAPFVS
                     FLCSPEADRVNGQVFLVYGGMVALMRPPSVEQRFDTVNGTWTADELATSVGGYFADRDP
                     ERMFSASEIMSLP"
     aSDomain        complement(2625..3137)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS17225_PKS_KR.1"
                     /evalue="2.30E-14"
                     /label="CVV72_RS17225_PKS_KR.1"
                     /locus_tag="CVV72_RS17225"
                     /protein_end="177"
                     /protein_start="6"
                     /score="45.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAIVTGAGAGLGRAEALALAAAGASVVVNDVSAAARAVADEIEAE
                     GGKAIAVTGDVSESATADALLTAAVDHFGGLHLLVNNAGVLRDRMLFSMTDDEWDTVLR
                     VHLRGHFLLSRNAGAYWRDKSKVDGAPVYGRVVNTASESFLLGAPGQPNYGAAKAGIAA
                     LTVSAARG"
     misc_feature    complement(3197..3209)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.42"
                     /tool="antismash"
     gene            complement(3227..3418)
                     /locus_tag="CVV72_RS17230"
                     /old_locus_tag="CVV72_17160"
     CDS             complement(3227..3418)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033756.1"
                     /locus_tag="CVV72_RS17230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17160"
                     /product="ferredoxin"
                     /protein_id="WP_219153345.1"
                     /transl_table=11
                     /translation="MEIDVDRSLCEANAICVGFAPEVFDLDDDEELVLASAEVPQNQVE
                     RVTQAVASCPKNALLMRG"
     gene            3522..4703
                     /locus_tag="CVV72_RS17235"
                     /old_locus_tag="CVV72_17165"
     CDS             3522..4703
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075193.1"
                     /locus_tag="CVV72_RS17235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17165"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_219153346.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6e-22, bitscore:
                     77.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.1e-21, bitscore:
                     75.7, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8.3e-37, bitscore:
                     125.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIDYTPEQRALAAELREYFAGLMTPERREALAGAGGEYGDGLVY
                     KEIVRDLGSAGRLAIGWPREYGGQDRSMLDQLVFTDEAAAAGVPVPFLTVNTVGPTIMR
                     YGTEEQKAFYLPKIAAGELHFAIGYSEPGAGTDLASLRTRAIRDGDDYVINGQKMWTSL
                     IEYADYVWLAARTDPDARKHKGLSMLIVPTSAPGFSWTKVHTVAGPGTSATYYDDVRVP
                     VTSRVAGENEGWPLITNQLNHERVALTSAAPIQTSLREVRSWAQATKLPDGSRVLDQPW
                     VRLHLARIHTHAEYLKLRNWRIAWAAASGDLGPAEASATKVFGTEFATEAYRLMMEILG
                     AGAVVREGSPGAQLRGRIERLHRSSLILTFGGGTNEIQRDMIAATALGLPVTR"
     gene            4713..5786
                     /locus_tag="CVV72_RS17240"
                     /old_locus_tag="CVV72_17170"
     CDS             4713..5786
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033758.1"
                     /locus_tag="CVV72_RS17240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17170"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_219153347.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.1e-13, bitscore:
                     50.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.4e-31, bitscore:
                     107.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLTEAQQDLASLTRRILTDKVTPDVLGPHGSGGFDAPLWTSL
                     AQAGVLDAALPQSVGGGGFGLLEQCSVLTEIGRAVAPVPYLTSVVLGAAAVAEFGDGRL
                     AEHWVVPILRGDHVLAVALPDYGVPCGFTAEADGDGWRLTGAQTAVPSGAFAHGFLVEA
                     AIDGGRQVFLLDRDTVTVSPQRTVDHADAALVELSGAKSATSLGDIGEWLRLRGTIGVC
                     AQQLGVAERALELTAAYAREREQFGNLIGSFQAVRQRLADAYVDVEAVRLTLWQAAWRL
                     SEGLPAAEEVATAKFWTAEAGHRVAHTAVHVHGGVGIDVDHTLHRYFVAAKRLEFTWGG
                     ATAQLRGLGDLLAADPA"
     gene            5783..7294
                     /locus_tag="CVV72_RS17245"
                     /old_locus_tag="CVV72_17175"
     CDS             5783..7294
                     /NRPS_PKS="Domain: AMP-binding (17-396). E-value: 1.9e-63.
                     Score: 206.4. Matches aSDomain:
                     nrpspksdomains_CVV72_RS17245_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671688.1"
                     /locus_tag="CVV72_RS17245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17175"
                     /product="long-chain-fatty-acid--CoA ligase"
                     /protein_id="WP_219153348.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-63, bitscore:
                     213.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPTVTELLLARAEDHSTGLLFEDRRWTWAEHVRACAGHAAALTG
                     ILRPGGHFGLLADNVPEFSFLLGGAALSGHVLVGLNPTRRGAALARDVALADCELVFAE
                     DEYLPLLSEADVPVLPLSELKPAPEVSGPVPAKPDDLLMLIFTSGTSGDPKAVRCTHGK
                     IAYPGEMLATRFGLSTEDTVYVSMPMFHSNAIMAGWSVGLAAGAGIALRRRFSASGFLP
                     DVRRFGATYANYVGKPLSYVLTTPERDDDADNPLKLVYGNEGAEADLAAFGKRFGCHVV
                     DAFGSTEGGVNFGRDATTPAGSLGRLLDGVAVLDPETGKPCPPAKFDEDGKLLNAAEAV
                     GELVNTGGPGFFAGYYGDPAAEAERMRDGMYHTGDLAYLDADGYCYFAGRLGDWLRVDG
                     ENLGTAPIERALLRHPAVREAAVYGVPDPRVGDQVMAALACRSPIDPDEFAAFVVAQGD
                     LGPKQWPRFVRMVADLPRTATHKVLKRELAAEGTSGAWEVRYRTS"
     aSDomain        5834..6970
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS17245_AMP-binding.1"
                     /evalue="1.90E-63"
                     /label="CVV72_RS17245_AMP-binding.1"
                     /locus_tag="CVV72_RS17245"
                     /protein_end="396"
                     /protein_start="17"
                     /score="206.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="TGLLFEDRRWTWAEHVRACAGHAAALTGILRPGGHFGLLADNVPE
                     FSFLLGGAALSGHVLVGLNPTRRGAALARDVALADCELVFAEDEYLPLLSEADVPVLPL
                     SELKPAPEVSGPVPAKPDDLLMLIFTSGTSGDPKAVRCTHGKIAYPGEMLATRFGLSTE
                     DTVYVSMPMFHSNAIMAGWSVGLAAGAGIALRRRFSASGFLPDVRRFGATYANYVGKPL
                     SYVLTTPERDDDADNPLKLVYGNEGAEADLAAFGKRFGCHVVDAFGSTEGGVNFGRDAT
                     TPAGSLGRLLDGVAVLDPETGKPCPPAKFDEDGKLLNAAEAVGELVNTGGPGFFAGYYG
                     DPAAEAERMRDGMYHTGDLAYLDADGYCYFAGRLGDWLR"
     CDS_motif       6209..6265
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CVV72_RS17245_0001"
                     /evalue="1.20E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="CVV72_RS17245"
                     /protein_end="161"
                     /protein_start="142"
                     /score="18.0"
                     /tool="antismash"
                     /translation="MLIFTSGTSGDPKAVRCTH"
     CDS_motif       6797..6877
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CVV72_RS17245_0002"
                     /evalue="2.40E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="CVV72_RS17245"
                     /protein_end="365"
                     /protein_start="338"
                     /score="10.4"
                     /tool="antismash"
                     /translation="AVGELVNTGGPGFFAGYYGDPAAEAER"
     gene            complement(7455..8000)
                     /locus_tag="CVV72_RS17250"
                     /old_locus_tag="CVV72_17180"
     CDS             complement(7455..8000)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="CVV72_RS17250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17180"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_158005430.1"
                     /transl_table=11
                     /translation="MSGILSNGSRAGVCDPALLESMLFSPGRRRLVVDSRLAGGELVRH
                     HEKARQTEIRVYGGVLRHMLVFDARYAVVPLDELSLHAGALVLRPPLVGPCGQFFGVLW
                     SESRPLGGGPGRGACLKGRQRQVADLLVEGATDHQVANRLGLSSRTVRTIVSELHDRFG
                     TTSRMALGFRLGRVTKRV"
     misc_feature    8009..8022
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.77"
                     /tool="antismash"
     misc_feature    complement(8025..8039)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            complement(8238..10004)
                     /locus_tag="CVV72_RS17255"
                     /old_locus_tag="CVV72_17185"
     CDS             complement(8238..10004)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670108.1"
                     /locus_tag="CVV72_RS17255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17185"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219153349.1"
                     /transl_table=11
                     /translation="MSDRAGVRDLLRLTAGHRRVLTLAIVLTVAASGLGMLQPLLVRHG
                     IDSVGTRPLSWWFIAGIAGLFLVQAAVDGLGLFMLERSGERVVLSVRKRLIARLLRLRM
                     PAYEDHRLGDLLSRLSVDTTVLRDVVSTASVQLVAGGLTGLGTAVLMLLLDPVLFGLVA
                     ATVSVAAVVVAALLGRLRAAGERTQRGVGEMAADLERALGAIRMVRANRAEPREERRIG
                     ERAESAFAAGAQAAKLTSVMTPAVELAIRGSLLLVLLVGGARVAANATSLGELVAFLLY
                     ATYLVVPLISLLQGIGLVQRGMGALQRVHEASLLPVESDTAPRSPILPVRSAPVLEFRE
                     VRFSYGKRTVLDGVSFRVEPRTSVALVGKSGAGKSTVFSLAERFYQPFSGTVLLNGADL
                     NGMSLSDCRSRLALVDQNVPILHGTLRENLVYAAPDADAEDLARVLETVNLAGLVAGLP
                     DGLDTQVGERGNMLSGGERQRVAIARALLTRPDLLLLDEPSAHLDRINEFALTMALERA
                     GRECALLVIAHRLATVRRADRILVLDEGRIAGDGTHDELTVSCPLYRRLVENQLSEDRS
                     AGSRAAEAASAG"
     gene            complement(10001..10432)
                     /locus_tag="CVV72_RS17260"
                     /old_locus_tag="CVV72_17190"
     CDS             complement(10001..10432)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007031547.1"
                     /locus_tag="CVV72_RS17260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17190"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_219153350.1"
                     /sec_met_domain="PF13471 (E-value: 7.6e-27, bitscore: 92.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALSRSRSLPFARRLAARLAVAVARLIAMLPPHRIRVVFGV
                     LRRGARPATCEQAEAAREAVLAVSLACLGPKGCLPRSLAVTLLCRSRGVWPTWCVGVRA
                     RPPFGAHAWVEVDGQPVGEGVSAGYFARLVAVGPPDRVR"
     gene            complement(10429..10686)
                     /locus_tag="CVV72_RS17265"
                     /old_locus_tag="CVV72_17195"
     CDS             complement(10429..10686)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="CVV72_RS17265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17195"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_219153351.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.4e-26,
                     bitscore: 91.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 2.3e-06,
                     bitscore: 26.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.3e-16, bitscore: 58.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLAFRPNVSIVDTDYGSVLLDERKGRYFQLNPSGRIVVRTLLEG
                     GDSEEAAGALIEEYDVSRERAEQDVTALVEGLRAAGLVTS"
     aSDomain        complement(10435..10683)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CVV72_RS17265_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.00E-29"
                     /identifier="RREFam002.1"
                     /label="CVV72_RS17265"
                     /locus_tag="CVV72_RS17265"
                     /protein_end="84"
                     /protein_start="1"
                     /score="91.2"
                     /tool="antismash"
                     /translation="SLAFRPNVSIVDTDYGSVLLDERKGRYFQLNPSGRIVVRTLLEGG
                     DSEEAAGALIEEYDVSRERAEQDVTALVEGLRAAGLVT"
     gene            complement(10683..12527)
                     /locus_tag="CVV72_RS17270"
                     /old_locus_tag="CVV72_17200"
     CDS             complement(10683..12527)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="CVV72_RS17270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17200"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_219153352.1"
                     /sec_met_domain="Asn_synthase (E-value: 4.6e-42, bitscore:
                     143.8, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQVTDTLGHGEEYFAVFPDHEATLAVAPRLHAPGSRTLAHASGR
                     PWLTGRWPDDGIVVASAGRTRLAVIGWCPVTEKELTAAAARLRDPGGLDALATKLPGSF
                     HLVASVDGHCRVQGTASGLRLVHHTRIGGVVVAADRADILAHAAGADIDERMLAVRLLF
                     PVPHPLLHKPMWRGVHGVEPGSALMLAPDGVAARTVRWWDPPRPERSLAEGAPLVREAL
                     TAAVDARTAAGGVVACDLSGGLDSTSVTFLAARGDAKIVASTWPGLDPADDDLAWAARA
                     AAHLPEVEHVVWDVAASPLVYAGLLEIDDPLDEPTIGMMDRARLLSDLGPLAAKGSRVR
                     LTGIGGDHVAWCSEAHYHTILRRRPLFALGALRGFRALFTWPLGGMVRALADSRSYRRW
                     LSDAAADVRAAKTAPVTAALGWSTPPRLFDWATPEAKELASAEIRDAALAAEPLGRTRG
                     EHADLEQILSCTRIIRQWEQMSARAGLPIQSPFFDDRVIEACLSIRPDDRVTPWAYKPV
                     LTEAMRGVVPGECLARTSKAQASMDAAAGLRASRGDLRELWADSRLAEFGLVDRNRLGA
                     LASRPETPELRDGILYPTIGCEVWLRTLSKPLLSLEEK"
     misc_feature    complement(12545..12556)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
     gene            complement(12549..12656)
                     /locus_tag="CVV72_RS17275"
     CDS             complement(12549..12656)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="CVV72_RS17275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_103746198.1"
                     /transl_table=11
                     /translation="MKEYETPMLIDAGEFEEVTGLLARHGNDRLIFSKN"
     misc_feature    complement(12820..12834)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            12879..13976
                     /locus_tag="CVV72_RS17280"
                     /old_locus_tag="CVV72_17205"
     CDS             12879..13976
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332761.1"
                     /locus_tag="CVV72_RS17280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17205"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_219153353.1"
                     /transl_table=11
                     /translation="MKRTTRRIGVLATALALPAVLLAPSASAAPVRLSLPVPTGPHAVG
                     VTDLHLIDHSRQDPWIPGAARELMVTVRYPALPSGKPKAPYMAPGVAKVVAEGDAVKLG
                     MAVDRLDYRFPTHSRIGAPAIGGERPVVLYSPGGTLSRSHGTTHQEQLASEGYVVVAID
                     HTHEAEAVEFPGGRVAKKALPPSSIEVSKRVIDTRVRDTRFVLDSLGLSQAGMFGHSAG
                     GFTAGETMVTDRRVVAGANLDGSMAHSQSQRIFGRVADEGLDRPFLLMSAGDHSAASDA
                     SWQEFLSNQRGWTRETRLPDGEHFSFTDYQTLLPQLGNAPAAFVGTIDPARSVAAQRAH
                     LSTFFGKTLRHRSSDVTKVSLSQAS"
     gene            complement(13928..14533)
                     /locus_tag="CVV72_RS17285"
                     /old_locus_tag="CVV72_17210"
     CDS             complement(13928..14533)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332760.1"
                     /locus_tag="CVV72_RS17285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17210"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_219153354.1"
                     /transl_table=11
                     /translation="MPADLPGIVRLRDRREALTLRTILTAARGLFAERGYARTPIRLIA
                     QEAGVSPQTIYAHFGSKAGVLGGLVDLLDDEAGIPDLVAEAQRTGDPVALLGLLATVAR
                     QVRERCGDIVTMLSSGAAVDPDIAATQAEGARRNRLGVEMVVGRVRESGRAVVPRAADI
                     AVALMSADVHTSLVAGAGWSHDDYEAWLKDTLVTSLLR"
     gene            14597..15022
                     /locus_tag="CVV72_RS17290"
                     /old_locus_tag="CVV72_17215"
     CDS             14597..15022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164620.1"
                     /locus_tag="CVV72_RS17290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17215"
                     /product="SgcJ/EcaC family oxidoreductase"
                     /protein_id="WP_219153355.1"
                     /transl_table=11
                     /translation="MTTEEIITALERAWNAGDGEAWAANFAEDADFVDVVGRIQRGRAT
                     IARESQNIFDTIYRGSTLRIRQVSSRPLGGGFDLVHTATTLTIPAGPLAGEARAVQTKL
                     VHEGRIVAFHNTIRGDIAAFTGHDADLAARSPQEWDS"
     gene            complement(15029..17722)
                     /locus_tag="CVV72_RS17295"
                     /old_locus_tag="CVV72_17220"
     CDS             complement(15029..17722)
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332758.1"
                     /locus_tag="CVV72_RS17295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17220"
                     /product="bifunctional GNAT family
                     N-acetyltransferase/acetate--CoA ligase family protein"
                     /protein_id="WP_219153356.1"
                     /transl_table=11
                     /translation="MASEDTKRDPYDFPREWEADVLLSDGGTVHLRPVIPSDADGLVAF
                     HGRLSERTRYFRYFGAYPRIPQRDLERFSVVDHHDRVAFVALLGDDIVAVGRYERLEHG
                     PSAEVAFVVDDVHQGRGLGSILLEHLAAAASECGLRRFVAEVLAENAAMVRVFRDAGYQ
                     VSREIEEGVLHLEFDIDPTEESLAVARSREQAAEARSVHNLLHPKSVAVIGASTDPTKI
                     GYVALTNLLSADFAGTVYPVNPEHKSVRGVRAYPSVVDIPEDVDLALVAVPAEAVESVL
                     DGALAKGVKTLLIVSGGFAEAGPHGLHAELRLVGEARAHGMRVVGPNALGVLNTDASVR
                     LNATLAPRLPARGRTGFFCQSGALGTAILADAEARGLGLSTFVSAGNRADVSGNDLLQY
                     WETDPATDLVLLYLESFGNPRKFARLARRLARTKPVVAVKSGRHAVRPQLAATSAEVDE
                     SSVQALFEQAGVVRVDTLAQLFDTALVFAHQPLPAGPRVAIVGNSSAIGLLAADTARAH
                     GLRLTADPVDVGPQASPEEFAAAVREALNSPETDALVVVFVPPLAIPGTAYARALREAV
                     VEMDKNKPIVSTFLAVEGVPDELAVLSEDGVPTRGSVPSYPSPERAVNALARVVRYAAW
                     RQRPQGNLVRPAGLHAEQAQVIVRELLAGEDGKTTLLSDDDVVRLLGCYGIDVVPFRVA
                     SSADEAVKSAEELGFPVTLKAVDERLRGRPDLAGVRLDLSSVDGVRRAYADLREISQDD
                     EVYVQRMAPKGISCVVGLQDDPSFGTLVSFGLSGLVSTLLGDRAYRAVPLTDVDAATLL
                     REPRTSPLLTGYRGDEPADLAALQDIVLRVAALAEDNPEVRSMTLDPILASPDGAFVAN
                     ARIVLGPPPSRPDTGPRRLRPINAPA"
     gene            complement(17724..18896)
                     /locus_tag="CVV72_RS17300"
                     /old_locus_tag="CVV72_17225"
     CDS             complement(17724..18896)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332757.1"
                     /locus_tag="CVV72_RS17300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17225"
                     /product="acetoin utilization protein AcuC"
                     /protein_id="WP_219153357.1"
                     /transl_table=11
                     /translation="MRAPAVVWDSSLLGYDLGGEHPFNPVRLELTIRLATELGVLDGVD
                     LLVPGPAGEDELRRVHLAEYIEAVRQAPMTGADFAHGLGTEDNPVFTGMHEASALVVGS
                     TLLAARKIAEGEATRAVNIAGGLHHAMPGKASGFCVYNDCSVAISWLLDHGFDRIAYVD
                     TDVHHGDGVQTAFYDDPRVLTVSLHQHPFTLWPGTGYSGEIGKGGAEGTAVNLPLPPGT
                     RDGGWLRAFEAVVPSLLEQFRPQILVTQCGVDSHEEDPLADLSLSVDGHRAIYRRLREL
                     SEAHAGGRWLAVGGGGYQLIRVVPRSWTHLLATVLGRDVDPATALPPNWVASISRAAPK
                     AEIPAGMSDGRETAFVPWGDGEDEPVDIAIRDTRRAIFPLHGLDPDDPRD"
     gene            complement(19050..19898)
                     /locus_tag="CVV72_RS17305"
                     /old_locus_tag="CVV72_17230"
     CDS             complement(19050..19898)
                     /EC_number="2.8.1.-"
                     /GO_function="GO:0016783 - sulfurtransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164628.1"
                     /locus_tag="CVV72_RS17305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17230"
                     /product="sulfurtransferase"
                     /protein_id="WP_219153358.1"
                     /transl_table=11
                     /translation="MRPMITTSELAARLSGPESARSVVLDVRWRLAGPPGADSYREAHL
                     PGAVYVDLDTALAGEPGDGGRHPLPEPETLQRHLRAAGVRAGHPVVVYDDADGSVAARA
                     WWLLRWAGHTEVAVLDGGFAAWAEEERPVTDEVPSPAEGDIVVKPGGMPVLDADEAAAL
                     ARDGLLFDARARPRYAGETEPIDPRAGHIPGAVNAPFSGHLGEDGRWRDASELAERFEG
                     LGVAPGTPVGVYCGSGVTASSVVLALEVAGHPEPAALYAGSWSHWSRDPERPVATGDLP
                     G"
     gene            20007..20726
                     /locus_tag="CVV72_RS17310"
                     /old_locus_tag="CVV72_17235"
     CDS             20007..20726
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224289.1"
                     /locus_tag="CVV72_RS17310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17235"
                     /product="metal-dependent transcriptional regulator"
                     /protein_id="WP_091597341.1"
                     /transl_table=11
                     /translation="MSNADEGDSVNDLIDTTEMYLRTIYELEEEGVVPLRARIAERLQQ
                     SGPTVSQTVARMERDGLVVVADDRHLQLTEHGRELAIAVMRKHRLAERLLVDVIGLEWE
                     HVHNEACRWEHVMSEAVERKLVKLLDHPTTSPYGNPIPGLDKLGDGDPAPPAEADLVRL
                     DEFARMGGGEVEIRRIAEHVQLDETLMTELKSVGIVPGNRVKVGKTAPGGTIEVTGGSS
                     SAQVPVSALHAVLAQAR"
     misc_feature    complement(20046..20060)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            20723..21904
                     /gene="galK"
                     /locus_tag="CVV72_RS17315"
                     /old_locus_tag="CVV72_17240"
     CDS             20723..21904
                     /EC_number="2.7.1.6"
                     /GO_function="GO:0004335 - galactokinase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006012 - galactose metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0046835 - carbohydrate phosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="galK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224288.1"
                     /locus_tag="CVV72_RS17315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_17240"
                     /product="galactokinase"
                     /protein_id="WP_219153359.1"
                     /transl_table=11
                     /translation="MSAASDAAETFLALHGRAPSGVWSAPGRVNLIGEHTDYNDGFVLP
                     FALPHRLAAAATPREDGVLTVATLGSDGRVQESGPLAIADLRPGSVEGWAAYPAGVAWV
                     LRDQGLGGGADVTIAGNVPSGAGLSSSHALECAVALALLGLAEITPGTGGGSPSLHEVA
                     RWVQRSENDFVGAPTGLLDQTASLCCTESNVLFLDVRSGEMEQVPFPLEESGVRILIVD
                     TRTKHSHAEGGYGERRRGCERAAELLGVKALRDIGIDGLDAALERLPDELVPLVRHVVT
                     ENQRVLDTVDLLRAGRIAEIGPHLDASHASMRDDYLISTRELDLAVDSAREAGALGARM
                     TGGGFGGSAIALVRESDVDTVGRAVKAAYEAADLRHPRLFTAVPSRGAGRDQL"
ORIGIN
        1 ctgccgcgag gcgaggtacg acgaaagcag gccgacggcg tagagcggga tgaccgcggt
       61 gacgccggcg atcacccgtg tcgtcacgag atacggcagg ctcggcacgc ccatcacttc
      121 gagcgcgtcg atctcctcgg agatcttcat cgcgccgagc tgcgcggtga acccgcaacc
      181 gacggtggcc gaaagcgcga gcccggccga aagcggcgcg acctcacggg tgttgaagta
      241 cgccgagatg aacccggtga gcgcggcggt gccgagctgg ttcagcgcgg agtagccctg
      301 caggccgacg atgagaccgg tgaacagcgt catcccgatc atcacgccga gcgtcccgcc
      361 gatcaccgcg agcgcgccgg tgccgaagct gacctcggtc agcaggcgga agatctcgcg
      421 gccgtagcgc cggatcgtgc gcggggtcca ggccagcgcg cggaagtaga acgacagctg
      481 gccgccgaag ccttccagca tcgcgccggg gcgcgcgatg atttcgagcg tccggtccga
      541 aacagcgggt tcgcctgcca tgtcacatcg ccttcggcgg cacgatccgc aggtagatcg
      601 ccgtcagcac gacattgatc aggaacagca gcaggaacgt gatgaccacg gcctggttca
      661 ccgcgtcgcc gacacccttc ggcccgcccg ccgggttcag cccgcggaac gccgcgacca
      721 ccccggcgac gaaaccgtag aggagcgcct tgatctcact gatccacaga tcaggcacct
      781 gggcgagcgc gttgaaactg gcgaggtagg caccgggggt gccgccctgc atgacgacgt
      841 tgaagaagta gccgccgagc acgcccacga cgctgaccaa accgttcagc agcacggaaa
      901 ccacgatcgc ggcgagtacg cgcggcacga tcaggcgctg gatcgggttg accccgagga
      961 cctccatcgc gtcgatctct tcgcggatct tgcgggcgcc gatgtcggca cagaccgcgc
     1021 tgccgcccgc gcccgccacg agcagcgcgg tgatcagcgg gctcgcctgc tgcacgatcg
     1081 cgagcgcgct cgccgcgccg gtgaacgact gcgcgccgat ctgctgcgtc agcgagccca
     1141 gctgcaaggc gatgacggcg ccgaacggga tcgccacgag cgccgtcggc aggatggtga
     1201 cgctggcgaa gaaccagcac tgctggatcc attcgcggaa ctggaacggg cgtttgaaga
     1261 tcgcgcgcag gacttcccac gacagcgtcg cgagcctgcc gacctggatg agcgcacccg
     1321 tacccgggac ggacaccgat gcgttcacag aacctcccag tagcctgccc cgagtcttac
     1381 tccacctgtc aacgccccat tgcgttagcg gtgttcactc tgctctcggc acctccgcgt
     1441 cagtccatcc atgcccccgc caccaccctc agcggaggcg cttcgcgccc gatcaaaatc
     1501 tgagtgcgtg cgtggcacag gcgccgccgt cggcgacgaa ctccgaaccc gtgctgtacg
     1561 aactttcgtc actggccagg aacaacacga gtttcgcgat gtcctccggc tgtccgaccc
     1621 ggcccagggc gaccttcttg ccgacccacg acatgtcgac tttctgcccg ccggcggcgg
     1681 ccgcgaccat cggggtgtcg atcgcgccgg gatgcaccga attgacccgg atgttcttcg
     1741 cgccgagttc gagcgcggcg accttggtca tcccgcggat cgcgaacttg ctcgcggtgt
     1801 aggcgacgag gaacggcatc ccggcgagcc cttcgactga ggacacgttg acgatggagc
     1861 cgcctccggc cccggtcatc ggttcaacga ccgaacgcat cccgagaaac gccccgatct
     1921 ggttgacccg gatgacgcgt tcgtagtcgg cgagcgtggt cttgcccagt tccgagaaat
     1981 gcaggatgcc cgcgttgttg accagcacgg tcggcgggcc gaactccgag acggtgcgct
     2041 cgatcgcggc gtcccattcg gcctcgtcgc cgacgtcgag gtgctggtag acggcggact
     2101 cgccgagctc ggcggcgagt ttcttgccgt cgaggtcgtt gatgtcggcg atcaccacgc
     2161 gtgcgccctc ggcgacgaac agccgcgcgg ccgcctcacc ctgcccgcgg gcgccgccgg
     2221 tgatcagcgc aaccttgccg tcgagcctgc ccatcgtcat ctcctccgat tcacggcagc
     2281 gacatgatct cggacgcgga gaacatccgt tccgggtcgc ggtcggcgaa gtagccgccc
     2341 acgctggtgg cgagttcgtc ggcggtccag gtgccgttga cggtgtcgaa ccgctgttcc
     2401 accgacggcg gccgcatcag cgcgaccatc ccgccgtaga cgaggaacac ctggccgttg
     2461 acgcgatcgg cctcgggcga gcagaggaag gacacgaacg gcgcgacgtg gtcgaccgac
     2521 agcgggtcga tcccttccgg cgcgtcggcg ccgaaaacgg cttcggtcat cgccgtacgg
     2581 gcgcgcgggc agatcgcgtt ggcgcggacg ccgtagcggg aaaggccgcg cgcggcggag
     2641 acggtcagcg cggcgatacc cgccttggcc gcgccgtagt tcggctggcc gggcgcgccg
     2701 agcaggaacg actccgacgc ggtgttgacc acccggccgt acaccggcgc gccgtccact
     2761 ttggacttgt cgcgccagta cgccccggcg ttgcgcgaaa gcaggaaatg cccgcgcagg
     2821 tggacccgga gcacggtgtc ccattcgtcg tcggtcatcg agaagagcat ccggtcgcgc
     2881 agcacgcccg cgttgttgac caggaggtgc agcccgccga agtggtcgac ggcggcggtg
     2941 agcagcgcgt ccgcggtcgc ggactccgac acgtcaccgg tgaccgcgat ggccttgcca
     3001 ccctcggcct cgatctcgtc ggccaccgcc cgcgccgcgg ccgacacgtc gttgaccacc
     3061 accgacgctc ccgcggcggc cagcgccagc gcctcggccc ggccgagtcc cgcgccggcc
     3121 ccggtcacga tggccgtcct gccgtccaag ctcactccag gcctcctcgc ctctccgcac
     3181 acagtagaat ctgttcttgc tcaacgcaag cagcaaataa acggtgctaa ccacgcatga
     3241 gcagggcatt tttcggacag ctcgccacag cttgagtaac acgttctact tgattctgcg
     3301 gaacttccgc cgacgcgagg acaagctcct cgtcatcgtc gagatcgaag acctcgggcg
     3361 cgaagccgac acagatcgcg ttcgcctcac agagcgagcg atcgacgtcg atctccatat
     3421 tccctcctcg ccgccacacc tggtacaact agaacaggtt ctaccttacc gccgcgagcg
     3481 gccatggcac cagtaacgag caccgacggc agaggtgacg gatgcggatc gactacacgc
     3541 cggagcagcg ggcgctggcg gcggaactca gggagtactt cgccgggctg atgacccccg
     3601 aacgccgtga agccctggcc ggtgccggtg gcgaatacgg tgacggcctg gtgtacaagg
     3661 aaatcgtccg cgatctcggt agcgcgggcc ggctcgcgat cggctggccc cgcgagtacg
     3721 gcggacagga ccggtcgatg ctcgaccagc tcgtcttcac cgacgaagcg gccgcggcgg
     3781 gggtgcccgt cccgttcctc acggtgaaca ccgtcgggcc gaccatcatg cgctacggca
     3841 ccgaagaaca gaaggcgttc tacctgccga agatcgccgc cggcgagctg cacttcgcga
     3901 tcggctactc cgagccgggc gcgggcaccg acctggcgtc cctgcgcacc cgcgcgatcc
     3961 gcgacggcga cgactacgtc atcaacggcc agaagatgtg gacgagcctg atcgagtacg
     4021 ccgactacgt ctggctggcc gcccgcaccg accccgacgc ccgcaagcac aagggcctga
     4081 gcatgctgat cgtgccgacc tcggcccccg gcttctcctg gacgaaggtg cacacggtcg
     4141 ccgggccggg tacgagcgcg acctactacg acgacgtgcg cgtcccggtg acctcccggg
     4201 tcgccgggga gaacgagggc tggccgctca tcacgaacca gctcaaccac gaacgggtcg
     4261 cgctgacctc ggccgcgccg atccagacat cgctgcgcga ggtgcggagc tgggcgcagg
     4321 ccacgaagct gcccgacggc tcccgtgtcc tcgaccagcc gtgggtgcgg ctgcacctgg
     4381 cgcggatcca cacgcacgcc gagtacctga agctgcggaa ttggcgcatc gcctgggcgg
     4441 ccgcgagcgg cgacctcggc ccggcggagg cgtcggcgac gaaggtcttc ggcacggagt
     4501 tcgcgaccga ggcgtaccgg ctgatgatgg agatcctcgg cgcgggcgcc gtcgtccgcg
     4561 aaggctcccc tggcgcccag ttgcgcggcc ggatcgaacg gctgcaccgg tcttcgctga
     4621 tcctcacctt cggcggcggg accaacgaga tccagcggga catgatcgcc gccaccgccc
     4681 tcggcctgcc cgtcacgcgc taggagacat cgatggactt cacgctcacc gaagcgcagc
     4741 aggatctcgc ttcgctcacg cgccggatcc tgacggacaa ggtcaccccc gatgtgctgg
     4801 ggccccacgg ttccggcgga ttcgacgctc cactgtggac ctcgctggcg caggccgggg
     4861 tgctcgacgc ggcgctgccg cagtcggtcg gcggtggcgg gttcgggctg ctggagcagt
     4921 gttccgtact gaccgagatc ggccgcgcgg tcgcgcccgt gccctatctg acgtcggtcg
     4981 tcctcggcgc cgcggcggtc gcggaattcg gcgacggacg gctcgcggag cactgggtcg
     5041 tccccatcct gcgcggtgac cacgtcctcg cggtggcgct gccggactac ggcgtgccgt
     5101 gcgggttcac cgccgaggcc gacggcgacg gctggcggct gaccggtgcg cagaccgcgg
     5161 tgccgtcggg cgctttcgcg cacggattcc tcgtcgaagc cgccatcgac ggcggccgtc
     5221 aggtgttcct gctcgaccgg gacaccgtga cggtctcgcc acagcggacc gtcgaccacg
     5281 ccgacgcggc gctcgtcgaa ctgtccggcg cgaagtccgc cacgtccctg ggcgacatcg
     5341 gcgaatggct gcggctgagg ggcacgatcg gtgtctgcgc gcagcagctc ggcgtggccg
     5401 aacgggcgct ggagctgacc gcggcgtacg cgcgggagcg cgagcagttc ggcaacctca
     5461 tcgggagctt ccaggcggtg cggcagcggc tcgccgacgc ctacgtcgac gtcgaagccg
     5521 tccggctgac gctctggcag gccgcctggc ggctcagcga agggcttccg gcggccgagg
     5581 aggtcgcgac ggcgaagttc tggacagccg aggccgggca ccgggtcgcg cacaccgccg
     5641 tgcacgtcca cggcggggtc ggcatcgacg tcgaccacac gctgcatcgc tacttcgtcg
     5701 cggcgaaacg gctcgagttc acctggggcg gggcgaccgc gcagctgcgg ggactcggcg
     5761 acctgctggc cgcggacccg gcatgacccc cacggtcacg gaactcctgc tcgcgcgggc
     5821 ggaggaccac tcgaccggcc tgctgttcga agaccggcgc tggacctggg ccgaacacgt
     5881 ccgcgcctgc gccgggcacg ccgccgcgct caccggcatc ctgcggcccg gcgggcactt
     5941 cgggctgctg gcggacaacg tccccgagtt ctcgttcctg ctcggcggcg cggcgctgtc
     6001 gggacacgtg ctggtcggcc tgaaccccac gcgccggggc gcggcgctgg cccgcgacgt
     6061 cgcgctggcc gactgcgagc tggtgttcgc cgaggacgaa taccttccgc tgctgtccga
     6121 ggcggatgtc ccggtgctgc cgctgagcga gttgaagccg gcgccggagg tttccggccc
     6181 tgtgcccgcg aagccggatg acctgctcat gctgatcttc acctcgggca ccagcggcga
     6241 cccgaaggcc gtccggtgca cgcacggcaa gatcgcctac cccggtgaga tgctggccac
     6301 ccggttcggt ctgtccacag aggacaccgt gtacgtgtcg atgccgatgt tccactccaa
     6361 cgccatcatg gccggctggt cggtcgggct cgccgcgggc gcggggatcg cgctgcggcg
     6421 gcggttctcg gcctccggtt tcctgccgga cgtccggagg ttcggggcga cgtacgccaa
     6481 ctacgtcggc aagccactgt cctatgtgct caccactccc gagcgggacg acgacgcgga
     6541 caacccgctg aaactggtct acggaaacga aggcgcggaa gcagacctcg ccgctttcgg
     6601 caagcgtttc ggctgccacg tggtcgacgc gttcggttcg accgagggcg gcgtgaactt
     6661 cggcagggac gccaccaccc cggccggttc gctcggcagg ctgctcgacg gcgtcgccgt
     6721 cctcgacccg gagaccggga agccctgtcc cccggcgaag ttcgacgaag acgggaagct
     6781 gctcaacgcg gccgaggcgg tcggcgagct ggtcaatacc ggtggtcccg gcttcttcgc
     6841 aggctactac ggcgatccgg cggccgaggc cgagcggatg cgcgacggga tgtaccacac
     6901 cggcgacctg gcctacctcg acgcggacgg ctactgctac ttcgccggac ggctcggcga
     6961 ctggctccgc gtcgacggcg agaacctcgg caccgccccg atcgaacgcg cactcctccg
     7021 gcatcccgcc gtccgcgagg cggccgtgta cggggtaccg gatccgcgcg tgggcgacca
     7081 ggtgatggcc gcgctggcct gccggtcacc gatcgacccg gacgagttcg ccgctttcgt
     7141 ggtggcgcaa ggtgatctgg ggccgaaaca gtggccacgg ttcgtgcgga tggtcgcgga
     7201 cctgccgcgg acggcgacgc acaaagtgct caagcgggag ctggcggcgg aggggacctc
     7261 gggagcctgg gaggtgcggt accggacgtc gtgagctgct gcgatcgaca cgctgccgtg
     7321 cccatgagca ggtctcgacg gctctatgcg cggacccggc gggaggcgtg atgtcctggt
     7381 atccgtttct cgcatgggtc cccaagcggg gagcccgcct gcgaaaaagt gtctcttgtg
     7441 gacgcgaggc cgggctagac gcgtttggtc acgcggccga gacggaagcc caaggccatc
     7501 cgcgaagtgg tgccgaaccg atcgtgcaac tcggacacga tcgtgcgcac ggtcctgctg
     7561 ctcaggccga ggcggttggc gacctgatga tccgtggccc cctccaccag caggtccgcg
     7621 acctgccgct gccgtccctt gagacaggcg ccccggccgg gcccgccacc gagcggccgc
     7681 gactccgacc agaggacccc gaagaactgg ccgcagggac cgacgagcgg gggacgcagc
     7741 accagcgcgc ccgcgtgcag gctcagctcg tcgagcggca cgaccgcgta ccgggcgtcg
     7801 aagaccagca tgtgccgcaa cactccgccg tacaccctga tttcggtctg cctggccttt
     7861 tcgtggtgcc gcaccagctc accgcccgcc agccgcgagt cgaccaccag tcgcctgcgg
     7921 ccggggctga agagcatcga ctccagcagc gccgggtcgc agacgcccgc ccggctgccg
     7981 ttggaaagaa ttccggacac gagtttggtg gtttcacaaa aacgatcgat acgtctgagc
     8041 gtatcgcacc gtcccgacag cacctccacg aattccattc gccgagtcat ggggccatcg
     8101 gccagtcggt tgtagatcat ctgagcatca tcaccaccat ccgaataccc catccgacat
     8161 tcccagcgac ctattctcaa gagcgctcgg aggatgcgac agggccatcc gggggatgag
     8221 atgtccacaa tcggggatta tccggcggaa gccgcttcgg cagcccggct tccggcggac
     8281 cggtcctcgg acaactgatt ctcgacgagc cgccggtaca gcgggcagga cacggtgagc
     8341 tcgtcgtgcg tgccgtcgcc ggcgatcctg ccctcgtcga gcaccagtat ccggtctgcc
     8401 cggcggacgg tggccagccg gtgcgcgatg accagcagcg cgcattcacg tccggcccgc
     8461 tccagcgcca tagtcagcgc gaactcgttg atccggtcga gatgcgcgct cggctcatcg
     8521 agaagcagca ggtcaggccg cgtgagcagg gcgcgggcga tggcgacccg ctgccgctca
     8581 ccaccggaga gcatgttccc gcgttcaccg acctgggtgt cgagcccgtc gggcaggccg
     8641 gcgacgagcc cggcgaggtt gaccgtttcg agcacccgcg cgaggtcctc cgcatcggcg
     8701 tccggcgccg cgtacacgag attttcccgc agcgtgccgt gcaggatggg cacgttctgg
     8761 tcaaccagtg ccagccggga acggcagtcg gaaagtgaca ttccgttcag gtcggcgcca
     8821 ttcagcagta ccgttccgga aaagggctga taaaaacgct cggccagtga gaaaactgtc
     8881 gactttcccg ctcccgactt tccgaccaac gccacgctcg tccgcggttc gacccggaac
     8941 gaaacgccgt ccagcaccgt ccttttcccg taggagaatc ggacttcgcg aaattccagc
     9001 accggcgcgg agcgcacggg gagtatcggc gagcggggcg ccgtgtcgct ttcgacgggc
     9061 aagagagacg cttcgtgcac ccgctgcagc gcgcccatgc cgcgctggac gaggccgatt
     9121 ccctggagca gggagatgag cggcaccacc aggtaggtcg cgtacaacag gaacgccacc
     9181 agttcgccca gcgaggtcgc gttcgccgcc acccgcgccc cgccgacgag cagtaccagc
     9241 agaagcgagc cgcggatggc cagttcgacg gccggggtca tcaccgaggt cagcttggcc
     9301 gcctgcgccc cggcggcgaa ggccgactcc gcccgttcgc cgatccgccg ctcctctcgc
     9361 ggctccgccc ggttcgcgcg caccatccgg atcgcgccca gcgcgcgttc gaggtccgcg
     9421 gccatctcgc cgacgccgcg ttgcgtgcgc tcgcccgccg cgcggagcct gcccagcaac
     9481 gcggccacca cgacggcggc gaccgacacg gtcgctgcca ccaggccgaa cagcaccggg
     9541 tcgagcagca gcatcagcac cgccgtgccc agtccggtca acccgcccgc gacgagctgg
     9601 accgacgcgg tcgacaccac gtcgcgcagc acggtggtgt cgacgctgag ccgggagagc
     9661 aggtcgccga gccgatggtc ctcgtaggcg ggcatccgca gccgcagcag gcgcgcgatc
     9721 agccgcttgc gcacgctgag caccacgcgt tctcccgacc gctccagcat gaacaagccg
     9781 agcccgtcca cggcggcctg gacgaggaaa agcccggcta tgcccgcgat gaaccaccag
     9841 gagagcggcc gcgtgcccac cgagtcgatc ccgtgccgga ccagcaacgg ctggagcatc
     9901 cccagcccgg acgccgccac ggtgagcacg atggccagtg tcagcaccct ccggtggccc
     9961 gcggtcagcc gcagcagatc ccggacgccc gcccgatcgc tcatcggacc cgatccggcg
    10021 gcccgaccgc gacgagcctc gcgaagtacc cggcggagac cccttcgccg accggctgcc
    10081 cgtccacctc gacccaggcg tgcgcgccga acggcggccg cgcccggacg ccgacgcacc
    10141 acgtcggcca gacaccacgc gacctgcaca gcagcgtgac cgccagcgat ctcggcaggc
    10201 agcctttcgg gccgagacag gccaggctga ccgcgagcac cgcctccctc gcggcctccg
    10261 cctgctcgca ggtggcgggc cgcgcgccgc ggcggagtac gccgaagacc acccggatcc
    10321 gatgaggcgg cagcatcgcg atcagcctgg ccacggcgac cgccagccgc gcggcgagcc
    10381 gccgcgcgaa cggcagtgac cgcgacctgc tgagcgcgct cggggtggtc acgacgtcac
    10441 caggcccgcc gcgcgcagac cctccaccag cgcggtcacg tcctgctcgg cacgctcacg
    10501 cgagacgtcg tattcctcga tgagcgcgcc ggccgcttct tcgctgtcac cgccttccag
    10561 cagcgtccgc acgacgatcc ggccactcgg gttgagctgg aaataccggc ccttgcgctc
    10621 gtcgagcagc actgacccat agtccgtatc cacaatggac acgttcggac ggaacgcgag
    10681 gctcatttct cctccagaga gagcaagggc ttcgagagcg tgcgcagcca tacctcgcag
    10741 ccgatggtcg gatacaggat gccgtcgcga agctccggcg tttcggggcg cgatgccaag
    10801 gcgcccaagc gattacggtc gacgaggccg aactcggcca gccgcgagtc cgcccacagc
    10861 tcacgcaggt cgccccggct ggcccgcagg cccgccgcgg cgtccatcga cgcctgcgcc
    10921 ttgctggtgc gggccaggca ttcgccggga accacgccgc gcatggcttc ggtgagcacc
    10981 ggtttgtacg cccacggcgt cacccggtcg tccggcctga tcgacaggca ggcctcgatc
    11041 acccggtcgt cgaagaaggg cgactggatc ggcagcccgg cccgcgcgct catctgctcc
    11101 cattgccgga tgatccgcgt gcaggacagg atctgctcca ggtccgcgtg ctcgcccctg
    11161 gtcctgccga gcggctccgc ggcgagcgcc gcgtcgcgga tctccgcgct cgccagctct
    11221 ttcgcctccg gcgtcgccca gtcgaacaag cggggcggag tgctccagcc cagcgccgcg
    11281 gtcaccggtg cggtcttcgc cgcgcggacg tcggccgcgg cgtccgagag ccaccggcgg
    11341 tacgaacggg aatccgcgag cgcgcggacc atgccaccga gcggccaggt gaacagcgcg
    11401 cggaaccccc gcagcgcgcc cagtgcgaac aacgggcgtc gccgcagaat cgtgtgatag
    11461 tgcgcttccg agcaccaagc gacgtgatcg ccgccgatgc cggtcagccg gacccggctg
    11521 cccttggccg ccagcggtcc cagatcgctg agcagcctgg ccctgtccat catcccgatg
    11581 gtcggttcgt cgagcggatc gtcgatttcg agcaggcccg catagaccag cggagacgcg
    11641 gcgacgtccc acaccacatg ctcgacctcg ggcagatgtg ccgccgcgcg cgccgcccag
    11701 gcgaggtcgt cgtcggccgg gtcgaggccc ggccaggtgc tcgccacgat cttcgcgtcg
    11761 ccacgtgcgg cgaggaaggt caccgaggtc gagtccaggc caccggaaag gtcgcaggcg
    11821 accacgccgc cggcggccgt gcgcgcgtcc accgcggcgg tgagcgcttc ccgcaccagc
    11881 ggcgcgcctt ccgcgagcga gcgttccggg cgcggcggat cccaccaccg caccgtgcgg
    11941 gcggcgacgc cgtccggcgc gagcatcagc gcgctgcccg gctccacccc gtgcacccca
    12001 cgccacatcg gcttgtgcag caacggatgc gggaccggga acagcagccg gaccgcgagc
    12061 atccgctcgt cgatgtccgc gcctgccgcg tgagcgagga tgtccgcgcg gtcggccgcg
    12121 accaccacgc cgccgatcct ggtgtggtgg accagccgca gcccggacgc ggtgccctgc
    12181 acccggcagt gcccgtccac cgaggccacc aggtggaaac tgcccggcag tttcgttgcc
    12241 agcgcgtcga gtccgccggg atcgcgcagc cgcgcggccg cggcggtcag ttccttctcg
    12301 gtgaccgggc accagccgat caccgccagc ctggtccgcc ccgccgatgc cacgacgatc
    12361 ccgtcatccg gccaccggcc ggtcagccac ggccgccccg acgcgtgggc gagcgtccgg
    12421 gacccaggtg cgtgcaaccg cggggccacg gcgagagtgg cttcgtggtc gggaaagacc
    12481 gcgaagtact cctcgccgtg acccagcgtg tcagtgactt gacgcatcga cgcagacggt
    12541 cagcgcgttc agttcttgct gaagatcagc cggtcgttgc cgtgcctggc gagcaggccg
    12601 gtgacctctt cgaactcgcc ggcgtcgatc aacatggggg tctcgtattc cttcatggca
    12661 ctcacctttc gtcggatttc cttcggtccg ggcgtgcacg cgccatcacc gaacgtaaca
    12721 aggggttcgc ccgttcccca gcgaacggag cttccggaac cggcaattgc cacaagcggc
    12781 actcgagctg cgaacgagag ccccgggacc gatcccaggg tcgccaccgg tgatcttccc
    12841 gatgtcccgg gcccggcccg ctccctacgt tcggtgccat gaaacgaacc acgcgccgga
    12901 tcggcgtact cgccaccgcg ctcgccctgc ccgccgtcct cctcgcgccg tccgcgtcgg
    12961 cggcgcccgt ccggctgagc cttcccgtgc cgaccggccc tcacgcggtc ggcgtcaccg
    13021 acctccacct gatcgaccac tcccgccagg atccgtggat tcccggcgcg gcaagggaat
    13081 tgatggtcac cgtgcggtac ccggcactgc cgagcggaaa gccgaaagcg ccgtacatgg
    13141 cgccgggcgt ggcgaaggtg gtggccgagg gcgacgccgt caagctgggc atggcggtgg
    13201 atcggctcga ctaccgcttc cccacgcact cccggatcgg cgcgcccgcg atcggcggcg
    13261 agcggcctgt cgtgctgtat tcgcccggcg gcaccttgtc acggtcgcac ggcaccaccc
    13321 atcaggaaca actggcgagc gagggctacg tcgtcgtggc catcgaccac acccacgaag
    13381 cggaagcggt ggagttcccc ggcggccgag tcgcgaagaa ggccttgccg ccgtcgagta
    13441 tcgaggtgtc gaagcgcgtg atcgacactc gcgtccgtga cacgcgtttc gtcctcgact
    13501 cgctcgggct gagccaggcc ggcatgttcg gccactccgc cggcgggttc acggcgggcg
    13561 agacgatggt gaccgatcgg cgtgtcgtcg ccggggcgaa cctggacggc agcatggccc
    13621 actcgcaatc gcagcggatc ttcggccgtg tcgccgacga gggactggac cggccgttcc
    13681 tgctgatgag cgccggtgac cacagcgccg cgtcggacgc gtcctggcag gagttcctga
    13741 gcaaccagcg cggctggacc cgcgaaacgc gcctgccgga cggcgagcat ttcagcttca
    13801 cggactatca gaccctgttg ccccagctgg gcaacgcgcc cgccgcgttc gtcggcacga
    13861 tcgacccggc acggagtgtc gccgcacagc gcgcgcacct ctcgacgttc ttcggcaaga
    13921 cactgcgtca ccgaagcagt gacgtgacca aggtgtcctt gagccaggcc tcgtagtcgt
    13981 catgactcca cccggccccg gcgacgaggc tggtgtggac gtcggcgctc atcagggcca
    14041 cggcgatgtc cgcggccctg ggcaccacgg cgcgcccgct ctcgcggaca cggccgacga
    14101 ccatctcgac gccgagccgg ttgcgccggg caccttccgc ctgggtcgcg gcgatgtccg
    14161 gatcgacggc ggcaccggag ctcagcatcg tgacgatgtc gccacagcgc tcccggacct
    14221 ggcgggcgac cgtggccagc aggccgagca aggcgaccgg atccccggtc cgctgcgcct
    14281 cggcgacgag gtcggggatc ccggcctcgt cgtcgaggag gtcgacgaga ccgccgagga
    14341 caccggcctt cgaaccgaag tgggcgtaga tggtctgcgg ggacaccccc gcctcctggg
    14401 cgatgaggcg gatcggcgtc cgcgcgtagc cgcgctcggc gaagagaccg cgggccgccg
    14461 tcaggatcgt gcgcagcgtc agcgcctcac gacggtcgcg caaccggacg atgccgggaa
    14521 ggtccgcggg catgtatgct cctcgaaagt tggaacagtg ttctaagtaa tggatcgttg
    14581 ttataggagg atagcgatga ccaccgagga gatcatcacc gcgctggagc gcgcctggaa
    14641 cgcgggcgac ggcgaagcgt gggccgcgaa cttcgccgag gacgcggatt tcgtcgacgt
    14701 cgtcggccgg atccagcgcg gccgcgcgac gatcgcgcgc gagagccaga acatcttcga
    14761 caccatctac cggggcagca cgctgcggat ccgccaggtg tcgagccgtc cgctcggcgg
    14821 cgggttcgat ctcgtgcaca ccgccaccac gctgaccatc cccgccggtc ccctggccgg
    14881 ggaagcgcgg gcggtgcaga cgaaactggt ccacgagggg cggatcgtcg cgttccacaa
    14941 cacgatccgg ggcgatatcg cggcgttcac cggccacgac gcggacctcg cggcccgctc
    15001 gccccaagag tgggattcct gaccgggctc aagcaggcgc gttgatcggc ctcagccgcc
    15061 ggggcccggt gtcgggccgg gacggcggcg ggcccagcac gatccgcgcg ttcgcgacga
    15121 aggcgccgtc cggcgaggcg aggatcgggt cgagcgtcat cgagcggacc tcggggttgt
    15181 cctcggcgag cgccgcgacg cgcagcacga tgtcctggag cgcggccaga tccgccggtt
    15241 cgtcgccgcg gtatccggtc agcagcggtg aagtcctcgg ttcgcgcagc agcgtggcgg
    15301 cgtcgacgtc ggtgagcggg accgcgcggt aggcccggtc ccccagcagc gtgctgacca
    15361 gcccggacag cccgaacgac acgagcgtgc cgaacgacgg atcgtcctgc agcccgacca
    15421 cgcacgaaat tcccttgggc gccatccgct ggacgtagac ctcgtcgtcc tgggagatct
    15481 cgcgcagatc ggcgtacgcc cggcgcactc cgtccacaga ggacagatcg agccgcacgc
    15541 ccgctaggtc cggcctgccg cgcagccgtt cgtccacggc cttgagggtg accgggaacc
    15601 ccagctcttc ggccgacttc accgcctcgt cggcggacga ggcgacccgg aacgggacca
    15661 cgtcgatgcc gtagcagccc aggagccgga ccacgtcgtc gtcggagagc agcgtcgtct
    15721 tgccgtcctc gcccgccagc aactccctga cgatcacctg cgcctgctcg gcgtgcaggc
    15781 ccgcggggcg caccaggttg ccctgcgggc gctgccgcca agcggcatag cgcacgaccc
    15841 gcgcgagcgc gttcaccgcc cgttcgggac tcgggtacga cgggaccgaa ccccgcgtcg
    15901 gcaccccgtc ctcggacagc acggccagtt cgtccggcac cccctccacg gcgaggaagg
    15961 tcgacacgat cggcttgttc ttgtccatct cgacgacggc ctcccgcagc gcgcgggcgt
    16021 aggcggtgcc cgggatcgcg agcggcggca cgaagaccac gacgagcgcg tcggtctccg
    16081 gggagttgag tgcttcgcgc acggcggcgg cgaattcctc cgggctcgcc tgcggcccga
    16141 cgtcgaccgg gtcggcggtc agccggaggc cgtgcgcccg cgcggtgtcg gcggcgagca
    16201 gcccgatggc gctcgagttg cccacgatgg cgacccgcgg cccggcgggc agcggctggt
    16261 gcgcgaagac cagcgcggtg tcgaacagct gcgcgagcgt gtcgacgcgg acgacacccg
    16321 cctgctcgaa caaggcctgg acactggact cgtcgacctc cgccgacgtc gcggcgagct
    16381 gcgggcggac cgcgtgcctg ccggatttca ccgccaccac cggcttcgtc cgcgccagcc
    16441 gccgcgcgag ccgcgcgaac ttgcgcggat tgccgaacga ttccaggtac agcaggacga
    16501 ggtcggtcgc cggatcggtt tcccagtact ggagcaggtc gttgccggag acgtcggcgc
    16561 ggttacccgc cgagacgaac gtcgacagcc cgagaccgcg tgcctcggcg tcggcgagga
    16621 tcgcggtgcc cagcgcgccg gactggcaga agaaccctgt gcggccgcgc gccggcaggc
    16681 ggggcgcgag ggtggcgttg agccggaccg aggcgtcggt gttgagcacg cccagcgcgt
    16741 tcgggccgac gacccgcata ccgtgcgccc tggcctctcc gaccagccgc agctcggcgt
    16801 gcagcccgtg cggcccggcc tcggcgaaac cgccggagac gatcagcagg gtcttgaccc
    16861 ccttggccag cgctccgtcc aaaacggact cgacggcctc ggcgggcacg gcgaccagcg
    16921 cgagatcgac gtcctcggga atgtccacga cggacggata ggcgcggacg ccgcggacgg
    16981 acttgtgctc ggggttgacc gggtagacgg tgccggcgaa atcggcgctg aggaggttgg
    17041 tgagggcgac gtagccgatc ttcgtcggat cggtggacgc gccgatcacc gcgaccgact
    17101 tcggatgcag caggttgtgc acgctgcgcg cctcggcggc ctgctccctt gatcgggcga
    17161 ccgcgagcga ctcctcggtc ggatcgatgt cgaactccag gtgcagcacg ccttcttcga
    17221 tttcgcggct gacctggtag cccgcgtcac ggaacacccg caccatcgcg gcgttctcgg
    17281 cgagcacctc ggcgacgaaa cggcgaagcc cgcattccga ggcggcggcg gccagatgct
    17341 ccagcaggat cgacccgagc ccgcggccct ggtggacgtc gtcgacgacg aacgcgacct
    17401 ccgccgacgg cccgtgttcg agccgttcgt accggccgac cgcgacgatg tcgtcgccca
    17461 gcagcgcgac gaaggcgacc cggtcgtggt ggtcgacgac cgagaaccgt tcgaggtcgc
    17521 gctgcgggat ccgcggatag gcgccgaagt accggaagta gcgggtgcgt tcggacagcc
    17581 tgccgtggaa ggcgacgagc ccgtcggcgt cgctggggat caccgggcgg aggtgcaccg
    17641 tgccgccgtc ggagagcagg acgtcggcct cccactcgcg cgggaagtcg tacgggtcgc
    17701 gtttggtgtc ctcactggcc atgtcagtcc ctcggatcgt ccggatcgag gccgtgcagc
    17761 gggaagatcg cgcggcgggt gtcacggatg gcgatgtcga ccggctcgtc ctctccgtct
    17821 ccccacggga cgaacgcggt ctcgcgcccg tcggacatgc cggccgggat ctcggccttc
    17881 ggcgccgccc tggaaatcga cgcgacccag ttcggcggca gcgccgtcgc cgggtcgacg
    17941 tcgcggccga gcacggtcgc gagcaggtgg gtccaggagc gcggcaccac ccggatcagc
    18001 tggtagccac cgccgcccac ggcgagccag cggccaccgg cgtgcgcttc ggacagttcg
    18061 cgcagccgcc ggtagatggc gcgatggccg tccaccgaca gcgagagatc cgccagcggg
    18121 tcttcctcgt gcgagtcgac gccgcactgg gtgacgagga tctgcggccg gaactgctcc
    18181 agcagcgacg gcaccaccgc ctcgaacgcg cgcagccagc cgccgtcgcg ggtgccgggc
    18241 ggcagcggga gattgaccgc ggtgccctcg gccccgccct tgccgatctc ccccgagtag
    18301 cccgttcccg gccacaacgt gaacgggtgc tggtgcagcg agacggtcag cacccggggg
    18361 tcgtcgtaga aggccgtctg cacgccgtcg ccgtggtgca cgtcggtgtc gacgtaggcg
    18421 atgcggtcga aaccgtggtc cagcagccac gagatcgcca ccgaacagtc gttgtagaca
    18481 cagaaaccgg acgccttgcc cggcatcgcg tggtgcagcc cgccggcgat gttgaccgcc
    18541 cgggtcgcct cgccctccgc gatcttccgc gcggccagca gcgtcgagcc cacgaccagc
    18601 gcggaggcct cgtgcatccc ggtgaacacg gggttgtcct cggtcccgag cccgtgcgcg
    18661 aaatcggcac cggtcatcgg cgcctgccgg acggcctcga tgtattcggc gaggtgcacg
    18721 cggcgcagct cgtcttcgcc cgccgggccg gggacgagca ggtcgacccc gtcgagcacg
    18781 ccgagctcgg tggcgagccg gatcgtcagc tcgagccgca ccgggttgaa cggatgctcg
    18841 ccgccgaggt cgtagcccag cagcgaggag tcccatacga cggccggtgc tcgcatggtc
    18901 cgaactctag tgccccgcgg cggaaatacg gtgctcatcc cggtgggtcc aggtttccgc
    18961 cggcaaccga cgcggccgtc ggcaagcggg gctgccggga tccgcgccgg atttccgacg
    19021 caggcgacct gtgcccggac gcccgcgggt cagccgggca gatccccggt ggccaccggc
    19081 cgctccggat cacgcgacca gtgcgaccac gaacccgcgt acaacgccgc gggctccggg
    19141 tgaccggcga cctcgagcgc gagcacgacg gacgaggcgg tgacgcccga tccacagtag
    19201 acaccgaccg gcgtccccgg ggccacgccg agaccttcga accgttcggc cagctccgag
    19261 gcgtcgcgcc agcgcccgtc ctcgccgaga tgaccggaga agggcgcgtt gaccgcgccg
    19321 gggatgtgcc cggcgcgcgg gtcgatcggc tcggtctccc ccgcgtaccg cggcctcgcc
    19381 cgcgcgtcga agagcaagcc gtccctggcg agcgcggccg cctcgtccgc gtccagcacc
    19441 ggcatgccgc cgggcttcac gacgatgtcc ccctccgccg gcgaagggac ctcgtcggtg
    19501 accgggcgct cctcctcggc ccaggccgcg aacccgccgt ccagcacggc gacctcggtg
    19561 tgcccggccc agcgcagcag ccaccacgcc ctggccgcga ccgagccgtc ggcgtcgtcg
    19621 tagaccacga ccgggtgacc ggcgcggacc ccggccgccc gcagatgccg ctgcagcgtc
    19681 tccggttcgg gaaggggatg acggccgccg tcgcctggct ccccggcgag cgcggtgtcg
    19741 aggtcgacgt acaccgcgcc ggggagatgt gcctcacggt aggaatcggc gcccggcggg
    19801 ccggcgagcc gccagcggac gtcgagcact acggagcgtg ccgattccgg cccggatagc
    19861 cgcgcggcga gttcgctggt ggtgatcatg gggcgcatgg gtccatcttt ccgtgcgccg
    19921 gtgctccctg cccagcttgg gggacttttc ccggctcggt gcttgttctc cccacgcctg
    19981 cgtcgctgtc agtgccagcg actacgatga gcaacgcgga cgaaggggac agcgtgaacg
    20041 atctcatcga caccacagag atgtacttgc gtaccatcta cgagctcgaa gaagaaggtg
    20101 tcgtcccgct gcgggcccgg atcgcggagc ggctgcagca gagcggcccg accgtgagcc
    20161 agaccgtcgc caggatggag cgcgacggac tggtcgtggt cgcggacgac aggcatctgc
    20221 agctgaccga gcacgggcgc gaactcgcca tcgcggtcat gcgcaagcac cggctggccg
    20281 agcgcctcct ggtcgacgtc atcggcctgg agtgggagca cgtccacaac gaggcctgcc
    20341 gctgggaaca cgtgatgagc gaggccgtcg agcgcaagct ggtcaagctg ctcgaccacc
    20401 ccaccacgtc gccctacggc aacccgatcc cggggctcga caagctcggc gacggcgatc
    20461 ccgctccgcc cgccgaagcc gacctcgtgc ggctcgacga gttcgcccgc atgggtggcg
    20521 gcgaggtcga gatccgccgt atcgccgagc acgtgcagct ggacgagacg ctgatgacgg
    20581 agctcaaatc ggtcggcatc gtgcccggca accgggtcaa ggtcggcaag acggcgcccg
    20641 gcggcaccat cgaggtcacc ggcgggagca gttccgcgca ggtgcccgtg tcggcgctgc
    20701 acgccgtgct ggcgcaggcc aggtgagcgc cgcgtccgac gccgcggaga ccttcctggc
    20761 cctccacggc cgggctccgt ccggggtctg gtccgcgccg ggccgggtga acctgatcgg
    20821 tgagcacacc gactacaacg acggtttcgt gctgccgttc gcccttccgc accggctcgc
    20881 cgccgcggcg acgccgcgcg aggacggtgt gctgaccgtg gccaccctcg gctcggacgg
    20941 cagggtccag gagtccggcc cgctggccat cgccgacctg cggcccggct cggtcgaggg
    21001 gtgggccgcg tacccggcgg gggtcgcgtg ggtcctgcgt gaccagggcc tcggtggcgg
    21061 cgcggacgtg acgatcgcgg ggaacgtgcc gtcgggggcg ggcttgtcct cttcccacgc
    21121 gctcgaatgc gccgtcgcgc tcgccctgct ggggctcgcg gagatcactc cgggcaccgg
    21181 cgggggttcg ccgagcctgc acgaagtggc ccggtgggtg cagcgttcgg agaacgactt
    21241 cgtcggggca ccgaccggtc tgctcgacca gaccgcttcc ctgtgctgca cggaatcgaa
    21301 cgtgctgttc ctcgacgtcc gctccggcga gatggaacag gtgccgttcc cgctggagga
    21361 atccggcgtc cggatcctga tcgtggacac ccgcacgaag cattcgcacg ccgagggcgg
    21421 ctacggcgaa cgccgccggg gctgtgagcg cgcggcggaa ctgctcggag tgaaggcgct
    21481 gcgggatatc ggcatcgacg ggctggacgc cgcgctcgag aggctgccgg acgaactcgt
    21541 gccgctggtg cgccacgtgg tgacggagaa ccagcgcgtc ctcgacaccg tggatctgct
    21601 gcgggccggc cgtatcgccg agatcggccc tcatctggac gcctcgcatg cgagcatgcg
    21661 cgacgactac ctgatctcca cccgtgagct cgacctcgcc gtcgattcgg ctcgcgaagc
    21721 cggggcgctc ggcgctcgga tgaccggcgg cggcttcggc ggttcggcga tcgcgctggt
    21781 ccgcgagtcc gatgtggaca ccgtcgggcg agcggtgaag gccgcgtacg aagcggcgga
    21841 tctgcgccac cccaggctgt tcaccgccgt gccgtcgcgc ggcgccggcc gcgaccagct
    21901 ctagcccagg gccggccccg cggcgtgatc cgcgtgtttc aaggccgacc acgccggggc
    21961 cggattccgt agatcgcacc cgcacccccg ggcgcggccg gtgaccggga gcgaggacac
    22021 tgggccgcga ccgcatccgc agcagaaagg cgcgaacgtg accgacgaac cgaccaagac
    22081 cctgaagctg atggtgacgg gcggagccgg ttatgtgggc agcgtctgcg cggcccgcct
    22141 catcgaggcc gggcacgacg tcaccgtggt cgacgacctc tccaccgggc acgccgacgc
    22201 ggtgcacccg gacgccacct tcgtcgaggg tgacgccgcc gaggtcgccc ggcggctgct
    22261 cggcgacggc ttcgacggtg tcctccactt cgccgccaag tcgctggtcg gcgaatcgat
    22321 gacggatccg gcgaagtact gggaaggcaa cgtcctgacc tcgctccgcc tgctcgaggc
    22381 gatgcgcgat cacggcacga agcggctggt gttctcctcc accgcggcca cctacggcga
    22441 gcccgagtcc tcccccatcc cggagacggc gccgacgcag ccgacgaaca cctacggcgc
    22501 gacgaagctg gccatcgacc acgcgat
//
