LOCUS       NZ_CP024972            21128 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3392794
            Orig. end                         :: 3413922
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21128
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="20"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21128
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21128
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11128](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11128
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(226..239)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
     gene            934..2235
                     /locus_tag="CVV72_RS14990"
                     /old_locus_tag="CVV72_14920"
     CDS             934..2235
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005152170.1"
                     /locus_tag="CVV72_RS14990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14920"
                     /product="glycosyltransferase family 87 protein"
                     /protein_id="WP_219153013.1"
                     /transl_table=11
                     /translation="MTKDPDRRRLTIDLVFYTGCLVYAVVNTAVAEFYGYRVWANFAVA
                     GYGLAVVHTGWLTIAARCGKPLSGALGSRWLGIGAIGLFAMILPLGMLVIRRLTGVDWL
                     ITPVSWAAQPEVWVIERSAKLLLENGTPYVDVTALGRAVEVNDYTPYGPVMTVFGLPRA
                     LFGGGPVANALTDARWMFALAAVACVLLTLRLLKWPKIPVSAAQLALACPLTALTWAVA
                     GPDLAIVGLLVLSFALATTGRAILSGLVLALVVSAKLIVAPAIVVLGVLLITRRGPRAL
                     GGFAAALVVTTLVLHVPVYLAGPKAFVEHVLRFPLGIGVIKSPAASPLPGHLIASLGPV
                     GTAVSFALLGIAAVAILVWLLRRPPTTGSDALLRMAVGLVALIMLTPATRYGYLVYPLV
                     LLGARLAFLAAETRETAVPGKGTAPPAQQSATSS"
     gene            complement(2236..2445)
                     /locus_tag="CVV72_RS14995"
                     /old_locus_tag="CVV72_14925"
     CDS             complement(2236..2445)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003071237.1"
                     /locus_tag="CVV72_RS14995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14925"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_003071237.1"
                     /transl_table=11
                     /translation="MADLKKGARITGNTRDKLAADLKKKYEKGSSIRALAESTGRSYGF
                     VHRVLSESGVQLRGRGGATRVKKK"
     misc_feature    2437..2451
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: strong, score: 20.76"
                     /tool="antismash"
     gene            complement(2624..4252)
                     /locus_tag="CVV72_RS15000"
                     /old_locus_tag="CVV72_14930"
     CDS             complement(2624..4252)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645324.1"
                     /locus_tag="CVV72_RS15000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14930"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_034311834.1"
                     /transl_table=11
                     /translation="MITASGLQLRAGSRILLDDTNVRIQQGDRIGLVGRNGAGKTTSLK
                     VLAGEGEPYAGEVRRSGELGYLPQDPREGDLSVTAKDRVLSARGLDTLLRNMEKAQTAM
                     SELADEKERDKAVNRYSRLEERFASLGGYAAESEAARICSNLGLADRVLEQTLQTLSGG
                     QRRRVELARILFAAAEAGAGGKSETILLLDEPTNHLDADSINWLRGFLKQHDGGLVVIS
                     HDVELLADVVNKVWFLDATRGELDLYNMGWQRYLDARATDEKRRRRERANAEKKASALQ
                     QQAAKLGAKATKAVAAKNMARRAEQMLSALDETRQADKVARIKFPEPAPCGRTPLTAEG
                     LSKSYGSLEIFTGVDLAIDRGSKVVVLGLNGAGKTTLLRLLGGMETPDTGETIPGHGLR
                     LGYYAQEHETLDHDASVWENIRHLAPDTGAQELRNLLGSFLFTGEQLDQPAGTLSGGEK
                     TRLALAGLVSSAANVLLLDEPTNNLDPASRAQVLDALRSFAGAVVLVTHDPGAVEALEP
                     ERVILLPDGTEDHWSADYLELVQLA"
     gene            complement(4395..5063)
                     /locus_tag="CVV72_RS15005"
                     /old_locus_tag="CVV72_14935"
     CDS             complement(4395..5063)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333191.1"
                     /locus_tag="CVV72_RS15005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14935"
                     /product="acVLRF1 family peptidyl-tRNA hydrolase"
                     /protein_id="WP_219153014.1"
                     /transl_table=11
                     /translation="MARVRQVAGGGRAVEVAPDRLEGWYARFAVRNEGVRETELSPDTV
                     TVVADNGVVAVATVPFGPLNAEATVPGLAVGPLVEHALISRRIALLLVRRGGHSVGIAR
                     GGVVVQSRTDRHLVQGRSAAGGWSQQRFSRRREGQARSALRSAADDAFEVLVPHLSEVD
                     AVVLGGDRRALASLREDNRLAPLFQLAEARVLDIAEPRRTVLEDAAERAVAVQITLSGP
                     "
     misc_feature    complement(5147..5158)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.36"
                     /tool="antismash"
     gene            complement(5311..8181)
                     /locus_tag="CVV72_RS15010"
                     /old_locus_tag="CVV72_14940"
     CDS             complement(5311..8181)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224726.1"
                     /locus_tag="CVV72_RS15010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14940"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_219153969.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 4.7e-17, bitscore:
                     61.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTAGTAALVTALGLVSPPVAAAESGGSPEAFSANTVRQIEALQS
                     IKKSQNAGESKVDSRLLVEQKLRAQRMPASAVPALGSGANVSAAGTVLVDIRGQVSEEL
                     LKGLRESGAGIRAVSERYGSVRAEVPLNAVPAIAARADVKKVETANEAFTARQLAEPAT
                     AGKRESKEEKAARIADELKKAVDAKGQAGIAAGPVTSEGDRAHNADTARQQFGVTGVGT
                     KICALSDGIDSLATSQARGELPAGVDVIPGQEGDGDEGTAMLEIIHDLAPNAALGFASA
                     FNSDASFADNIRKLRFDAGCDVIVDDVLYFKESPFQDWIIAQAVNDVTSDGALYFSSAG
                     NEGNVTDGTSGHWEGDFVDSGKSVGKYAGTAHNFAGAAGNQIFQPLSSASGRVPVTLFW
                     SDPLGRSNNDYDLYLLNAAGNVVDFSQDVQSGTQDAYERVDTTGVAGLRLAIVKFSGEG
                     RYLSLSALRGRFSDSADGLKAYTSPGVTVGHSAARDAFSVAAAPAAKAFPRALEPGDPA
                     NPAGPFPGAFGAATKVERFTSDGPRRMFYQADGTPITPGNVSATGGEVRAKPDITAADG
                     VSTSVTGFTTFYGTSAAAPHAAAIAGLVLSGNPGLPPAEVREALINTAVDILAPGRDNS
                     SGAGVILADKVLAYTGASPQPLASAGQPTVTPADGGSALDPGDTAKVTLPVTNRGDGTA
                     TSTSVVLSSPTPGVTVAPRSKSYGTISPGQTGVNDFTITVPATQELGVPVVLTARVTFA
                     GSYSPTTSTFSLPVGTPSPVSRDFAYAGDAVAIPDSDPTGVTVPITVSGVGRASKLTFS
                     VDGATCNADQTSTTVGINHSYVGDLVGTLTSPSGAKATVFQRSGGSGNNLCQVVFADNA
                     ATAFSSVSAVNAPFTGTYKPAQAFGGLAAGSADGTWKFTAVDVAGGDTGSIRAISLHIN
                     GFVQPGVAERPAGVGKSVGRGPVKPV"
     gene            complement(8395..9957)
                     /locus_tag="CVV72_RS15015"
                     /old_locus_tag="CVV72_14945"
     CDS             complement(8395..9957)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637142.1"
                     /locus_tag="CVV72_RS15015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14945"
                     /product="deoxyguanosinetriphosphate triphosphohydrolase
                     family protein"
                     /protein_id="WP_219153015.1"
                     /transl_table=11
                     /translation="MEQTDPRAWRRDPESANAGFSDLATSPFRIDRDRIAASPFFARLG
                     GVTQVVSAGGAGLLHNRLTHSLKVAQVARAIAERINASSDSAELAAKLGGCDPDVAEAA
                     SLAHDLGHPPFGHLGEQTLDRIARHRFGLADGFEGNAQSFRIITTTDVRGPSASGLDLT
                     TAVRAAVLKYPWARLHVPDPHPTSMPVQPRGAAEPADAPGTGASKFSAYSTELDDFAQA
                     RAPFDGRIEPWQQTVEASVMDTADDIAYAIHDLQDFHRIGVLQHAPVAAEFSGWVDHAL
                     ELAGLDDATLTAERRLPGRSLERLRRRMHAKDGWIVDDDAFTSAVARVRAELVDGLLAT
                     GFDGSIEAEQATAAFSSKWTARLVDGVQVVASPSTRTGHLTLRPAQWHEVQVLKFVHRR
                     FVLLRPELALHQRGQASLVTTLVDALDAWLLDRDEFYRLPRRLHDLVELAQSEFSALAR
                     TSPELLIGATGEPVTGADAVRGLARGRAVVDFVASLTDKQAVTLLDGLSGRASQPWSDS
                     FVL"
     gene            10001..11128
                     /locus_tag="CVV72_RS15020"
                     /old_locus_tag="CVV72_14950"
     CDS             10001..11128
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005152183.1"
                     /locus_tag="CVV72_RS15020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14950"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_219153016.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 6.9e-46, bitscore:
                     155.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADVVIAGGGPAGRALARACARRGLETTLIDPAPGRRWRATYGLF
                     ADELPGLPGGAVACAPSTTLAFGTRPHVLDRRYLVMDNAGLRTWLDGGYDVVAGKVSGV
                     DHGGQGSSVRLEDGRILATGLYVDASGVRPRGDRYEQTAFGAVLPAEDALRLVDDPDTA
                     VFMDWREAESGFLYVLPLGDGTVLVEETSLARRPGLPLDVLAARLRARLKAVGLTSRGR
                     EERVRIVLDAPVPRRGRTVPFGTAAALVHPATGYSVTTSIRLAETVADAAAAAWDRGPA
                     AAASAAHRALWPSSARTVHGLRRHGLRALCGMPPELIPVFFDLFFTLPTSLQRAFTSGR
                     EDVSGNAEAMSTLFRMSPWTVRKHLIGWRALRRSR"
     misc_feature    11111..11113
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11201..11211)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            11201..12886
                     /locus_tag="CVV72_RS15025"
                     /old_locus_tag="CVV72_14955"
     CDS             11201..12886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029721.1"
                     /locus_tag="CVV72_RS15025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14955"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_219153017.1"
                     /transl_table=11
                     /translation="MTLQIAVRFAYQPLYSLHTGGVVAFEALARPGRGTAHELLADARR
                     SGRLAEVDVGLAAEAVRQLREPQAALPLHLNLSARTVAAPPAHFDPLTEALSLVGRRTR
                     DVVLEIGPPFTQIPADLLLTGMRRLTDLGFRLALDGLGRGDLPLTLLASAPVDLVKLDR
                     SVLRGLPHDPAAVAVVEAVLHFASRTDNRLVATGLETTEQLESARRLGVRIAQGNLLAP
                     PDGDHAPLPAPDAPGPFIPGTARARRVGDFLRPATTLPEDATCDDVREVLAAADGPSGI
                     VGIDDRHRPQWSIDRTRFLVAVTGLYGHALHAKRPASRLADRPHTIHADASALEFLELV
                     TDADWGRTGDDVVVVDDRGRCVGVVLVNEVVRGVAEAKVEEAVSLSPLTRLPGSDAVAR
                     DVDRRINAREPFVAAWLDVDSFKTVNDTAGFAAGDDLIRALGRTLTDLEARLRRMRVSH
                     VGGDDFLIACDVDEIGTVAAALLDTAWSADGLPVTVSLATLVCGHGAIRSYKDASRLLA
                     PLKKRAKEVPGSSWVLGRPGSDRVEVLRGITTRGLPSQRAAAGF"
     gene            complement(12955..14115)
                     /locus_tag="CVV72_RS15030"
                     /old_locus_tag="CVV72_14960"
     CDS             complement(12955..14115)
                     /EC_number="2.8.2.-"
                     /GO_function="GO:0008146 - sulfotransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050656 - 3'-phosphoadenosine
                     5'-phosphosulfate binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (extras)
                     Sulfotransfer_3: Sulfotransferase domain"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637145.1"
                     /locus_tag="CVV72_RS15030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14960"
                     /product="sulfotransferase"
                     /protein_id="WP_219153018.1"
                     /transl_table=11
                     /translation="MLPGRENVGTVEDLHASAAKLTGLDDFGGEDHLEGLRVLLDSYAG
                     EAGLTPYGNKIHRAFLRGALVARSLSEASWKQNPEYAEVPIERPIFVTGLPRTGTTALH
                     RLLTEDPAHQGLEVWLTEVPQARPPRETWAENPVFQGIQAGYEKHHVEHPEFMGLHHMS
                     ADQVEECWQLLRQSLKSVSYECLAHVPSYSRWLDGQSWTDAYRRHRRNLQLIGLPDAGR
                     RWVLKNPSHLFALDALLEVYPDALIVQTHRAPSTIVASVCSLNEQASAGWSEVFRGDVI
                     GRSQLDLWARGAEKSLEARKRHDPARFCDVRYEDFVADPIGTVEGVYRHFGLPLSDAAR
                     DAMTVVHAESRSGERKPVHRYDLADFGLTAGEVDERFSAYRAAYAL"
     gene            complement(14126..14908)
                     /locus_tag="CVV72_RS15035"
                     /old_locus_tag="CVV72_14965"
     CDS             complement(14126..14908)
                     /NRPS_PKS="Domain: PKS_KR (8-179). E-value: 1.6e-09. Score:
                     29.8. Matches aSDomain:
                     nrpspksdomains_CVV72_RS15035_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637146.1"
                     /locus_tag="CVV72_RS15035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14965"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_219153019.1"
                     /sec_met_domain="adh_short_C2 (E-value: 1.1e-32, bitscore:
                     112.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDLLRNKVIVVSGVGPGLGRSIAVRCAAAGADVVLAARTESRLA
                     EVAKEVDALGRRAVAVRTDITDDASAANLAEAAMKAFGRVDALVNNAFAIPPIMDLAEV
                     DLADVRAGFETNVLAALRLTRLFTSSLAERGGSVVMINSAVLRHSRRTFGAYKMAKASL
                     LALAQSLASELGPRGIRVNSVAPGYIWADSLKWYFAYLAKERGVPPEQVYAETAETIDL
                     RRLPEPDEIADTVVFLASSLARCVTGQCLDVNAGEYHH"
     aSDomain        complement(14372..14884)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS15035_PKS_KR.1"
                     /evalue="1.60E-09"
                     /label="CVV72_RS15035_PKS_KR.1"
                     /locus_tag="CVV72_RS15035"
                     /protein_end="179"
                     /protein_start="8"
                     /score="29.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIVVSGVGPGLGRSIAVRCAAAGADVVLAARTESRLAEVAKEVDA
                     LGRRAVAVRTDITDDASAANLAEAAMKAFGRVDALVNNAFAIPPIMDLAEVDLADVRAG
                     FETNVLAALRLTRLFTSSLAERGGSVVMINSAVLRHSRRTFGAYKMAKASLLALAQSLA
                     SELGPRGI"
     gene            complement(14905..16074)
                     /locus_tag="CVV72_RS15040"
                     /old_locus_tag="CVV72_14970"
     CDS             complement(14905..16074)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659116.1"
                     /locus_tag="CVV72_RS15040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14970"
                     /product="hypothetical protein"
                     /protein_id="WP_219153020.1"
                     /transl_table=11
                     /translation="MLTQPFADAIVEAEKVIAEAPHIRTEQDLVEGYDYLAGSIRASLQ
                     MAWAYERDYPFFTQSTGPYTKMGLDNPDTLYFNANIREDREYVVTGTRGSTADVSFQVL
                     NGDYSPVEVPDSLAAFDDREIEIAEDGTFELRFGPAKPGPGPNYFVLGPGSSMLVVREV
                     YSDWATERRGTIQIQCADTAGGAPAPLTRDGLAKRYGVTGKILLSRLRTFLAFPKWFYL
                     NLPVNTMTEPRPTPGGLTTQYSSAGHYELGDEEVMIVTVPRSDAPYQGIQLGSVWYLSL
                     DYINHQTSLTADQARVDPDGKIRFVISERDPGLANWLERTGHDRGYVQIRWQRLSRALE
                     KADGPEVEVVKFGELADRLPFHDEARVTPQEWADRISARQKAVAARMLG"
     gene            16162..17040
                     /locus_tag="CVV72_RS15045"
                     /old_locus_tag="CVV72_14975"
     CDS             16162..17040
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029717.1"
                     /locus_tag="CVV72_RS15045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14975"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_219153021.1"
                     /transl_table=11
                     /translation="MTRRSPPTERVVRLLDFFTAHPGRRIGLSELARELDLAKPTCLGI
                     VTELTAGGYLVRDPQPVTYRLGPAMVAAGRVASEGFGASEVARRHLEELSRRYGATCTA
                     SAVAGDRIVMVQSAGPGRIKLGETYPFAPPVGLMYVLWDSDAAFDAWLAKPPTVPVRLD
                     EAHLRRVVAECREHGYLVESLTSAGRRLYALMAGVGAEELPPEVRGLVGELVSSLGERV
                     YLGADLEPRRKHAVSLLAAPTFDASGRQELVLTLSVGEPITGAEIARRGAALVATADAV
                     TAESGGRHPRN"
     gene            complement(17098..17565)
                     /locus_tag="CVV72_RS15050"
                     /old_locus_tag="CVV72_14980"
     CDS             complement(17098..17565)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005152197.1"
                     /locus_tag="CVV72_RS15050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14980"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_219153022.1"
                     /transl_table=11
                     /translation="MDLVALEEIRRLKARYLRCLDLKLWDEMAETLTADAHARYGTPSY
                     GKPLTFESREAIVEFFRNAVGPGITTVHFAGQPEIDVDGDTATGTWLMRDKVIVPEHRV
                     VIEGAAYYEDTYRRVDGVWLTASTQYDRLYETMMSMDDVPSLKLTANRWSP"
     misc_feature    17637..17652
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.11"
                     /tool="antismash"
     gene            17643..18551
                     /gene="cysD"
                     /locus_tag="CVV72_RS15055"
                     /old_locus_tag="CVV72_14985"
     CDS             17643..18551
                     /EC_number="2.7.7.4"
                     /GO_function="GO:0004781 - sulfate adenylyltransferase
                     (ATP) activity [Evidence IEA]"
                     /GO_process="GO:0000103 - sulfate assimilation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cysD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637152.1"
                     /locus_tag="CVV72_RS15055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14985"
                     /product="sulfate adenylyltransferase subunit CysD"
                     /protein_id="WP_219153023.1"
                     /transl_table=11
                     /translation="MASPAYELTHLEALEAEAVHIFREVAATFERPALLFSGGKDSMVM
                     LHVAAKAFWPSPPPFPVMHVDTGHNFDEVIEFRDRTVDAYGLRLVVSSVQDDIDAGRVV
                     EDPKAGRNRLQTAALLRGIREHSFDAVFGGARRDEEKARAKERVFSFRDEFGQWDPRNQ
                     RPELWDLYNGRHRKGEHIRVFPLSNWTELDIWQYIEAENVDLPSIYYAHRRQVVQRDGM
                     LLAHTRFLTLYEGESPYEATVRFRTVGDATCTGCVESTATSPGEVVAEVAVSRLTERGA
                     TRADDRISEAGMEDRKKEGYF"
     gene            18551..20377
                     /gene="cysC"
                     /locus_tag="CVV72_RS15060"
                     /old_locus_tag="CVV72_14990"
     CDS             18551..20377
                     /EC_number="2.7.1.25"
                     /GO_function="GO:0004020 - adenylylsulfate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0000103 - sulfate assimilation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cysC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190: GTP-binding protein LepA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333180.1"
                     /locus_tag="CVV72_RS15060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14990"
                     /product="adenylyl-sulfate kinase"
                     /protein_id="WP_219153024.1"
                     /transl_table=11
                     /translation="MSASLVRLATAGSVDDGKSTLIGRLLFDSKTVFTDQLEAIERVSR
                     DRGEAYPNLALLTDGLRAEREQGITIDVAHRYFATPRRKFIIADTPGHVQYTRNMVTGA
                     STADLALILIDARKGVLEQSRRHAFLASLLGIPHLVLCVNKMDLVGWSQERFEEIREEF
                     RRFAMKLQVHDLTFVPMSALHGDNVVHRGASMPWYEGTSLLHHLEQVHVASDRNLIDAR
                     FPVQYVIREHSRDFRGYAGTVAGGVFKPGDEVAVLLSGFTTTVRAIWGPGGTTVTEAFA
                     SQAVTIELADDLDLGRGDLICRPGNRPHTSRDVDAMVCWFSEQGALKTGNDYVVRHTTR
                     ETKAEIRDLDYRLDVTTLHRDETAESLSLNEIGRIRLRARQPLLFDSYRRNRSTGGFLL
                     IDEHSGATVAAGMITGPSVTASNVVWHTAAVSRAERATRGLTVWLTGLSASGKSSVAVE
                     LERRLVASGRPAYLLDGDNLRHGLNGNLGFSPADRAENVRRVAEVAKLFADAGVVSVVS
                     LISPYRTDRELARAAHEAAGLPFLEVFVDTPLEVCEDRDPKGMYAKARAGEISGFTGVD
                     APYEQPENPDLVLRPENGDPAAMAALILAALE"
     gene            complement(20473..21126)
                     /locus_tag="CVV72_RS15065"
                     /old_locus_tag="CVV72_14995"
     CDS             complement(20473..21126)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637155.1"
                     /locus_tag="CVV72_RS15065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_14995"
                     /product="response regulator transcription factor"
                     /protein_id="WP_219153970.1"
                     /transl_table=11
                     /translation="MSIGVLLVDDEQLIRAGLRAIVASEPDLEVVGEASDGAEVPGLVS
                     RFRPDVVLMDVRMPSVDGIRATAHLMSTMDKPPKVIVVTTFENDDYVYDALLAGASGFL
                     LKRARPEEIVAAIRTVAAGESLLFPAAIRRLAAQQANRGPQDGLAGAGLTERECEVLRL
                     MAGGLSNVEIAGELYLGVQTVKTHVGNVLAKLGARDRTQAVIKAYDTGFVTPAG"
ORIGIN
        1 tcagcatcgc cgtccgcacc ccgatgtcgc gcacccgccc ggcccgcgca ccgaactcgc
       61 cagtctcgcg ctccgggtcg ccgaacagct tcaccagcgt cgcgcccggc gcggagaacc
      121 gctcggtcat ctgcgtggtc atcgacgcgt tgagcccgcc ggcctcccgc tgcagctcgg
      181 ccatccgccg tccgaggcgc cgcgtcggca ggatgaagac cggcagcaac accagtgcca
      241 gcagggtgac ctgccaggac aacgtcacca tgaccaccag cgacagcacc agctggatca
      301 cgttggtgac caaaccggac agtgtcgcgg tgaacgtgcg ctgtgcgccg atgacgtcgt
      361 tgttgagcct gctcaccagc gcgccggtgc gggtgcgcgt gaagaacgcg accggcatcc
      421 gctgcacgtg ccggtacacc gcgagccgca ggtcgaggat gatcccttca ccgatcctcg
      481 acgactgggc ccgttcggcc agcccgagcc cggcgtcgat cagcgccagc acggcgatca
      541 ccacggccag ccacaccacc agcgagacgt cgtgcccgcc gacgatcgcg tcgaccacct
      601 ttccggccag caccggcgtg ctgaccgcca gcaccgccga gacgacggtg agcgccagga
      661 atatcagcaa tctccgccag tgcggcctgg cgaaccgcgc gacgcggcgg agcgtcccct
      721 tgtgcagccc cttcggaaca tcggcggacc tcatcgccga gttcatcagc gcatacgtgt
      781 tgtccatgag aaccctctct tcgcccccaa aacctcgata ttagtcgaga gttttcccgg
      841 atataagcaa gaccaacacc gcggcgcccc ggatgcttcc cggtttccgc gtcctctttc
      901 cagcgggtgc ggccgcgtcg gtagcctgag ccggtgacca aggacccaga ccggcgacga
      961 ctgaccatcg acctggtctt ctacacgggc tgcctcgtct acgccgtcgt gaacaccgcc
     1021 gtcgcggaat tctacggtta tcgcgtgtgg gcgaacttcg ctgtagcggg ttacggcctc
     1081 gccgtggtcc acaccggctg gctgacgatc gccgcccggt gcggcaagcc gctgtccggc
     1141 gcactcggtt cgcggtggct cggtatcggc gccatcggcc tgttcgcgat gatccttccg
     1201 ttgggaatgc tcgtcattcg ccgtctgacc ggagtggact ggctcatcac gccggtgtca
     1261 tgggccgccc agcccgaggt ctgggtgatc gaacggtcgg cgaaactcct tctggagaac
     1321 ggaaccccgt acgtcgacgt caccgcgctc ggtcgcgcgg tggaagtaaa cgattacacg
     1381 ccatacggtc cggtgatgac cgtcttcggt ctgccacgcg ccctgttcgg cggcggaccg
     1441 gtcgcgaacg ccctcaccga cgcgcgctgg atgttcgcgc tggcggccgt cgcctgcgtg
     1501 ctgctgacgc tgcgactgct gaagtggccg aaaatcccgg tcagcgcggc acaactcgcg
     1561 ctcgcctgcc cgctgacggc gctgacctgg gcggtcgccg gccccgatct ggccatcgtc
     1621 ggcctgctgg tgctgtcctt cgcgctggcc acgaccggcc gcgcgatcct gtcgggtctg
     1681 gtgctggcgt tggtggtcag cgcgaaactc atcgtcgcgc ccgcgatagt ggtgctgggt
     1741 gtcctcttga tcacgcgacg tggccctcgc gcactgggcg gattcgccgc ggcactcgtg
     1801 gtgacgaccc tcgtcctgca cgtccccgtc tacctggccg gccccaaggc gttcgtcgag
     1861 cacgtcttgc ggttcccgct gggaatcggc gtgatcaagt caccggcggc gagcccgctg
     1921 cccggccacc tcatcgcctc gctcggcccg gtgggcacgg cggtttcctt cgccctgctc
     1981 gggatcgcgg ccgtcgcgat cctcgtctgg ctgcttcgcc gtcctcccac cactggctcg
     2041 gacgcgctcc tgcgcatggc cgtcgggctc gtcgcgctga tcatgctcac tccggcgacg
     2101 aggtacggat acctggtgta tccgctggtc ctgctcggtg ccaggctggc cttcctggcc
     2161 gcggaaaccc gtgaaacagc ggtccctgga aagggaactg cgccccccgc gcagcagtcc
     2221 gctacttcct cgtgactact tcttcttgac cctggtggca ccaccacggc cgcgcagctg
     2281 gacgccggac tccgagagga cccggtgcac gaacccgtac gagcgacccg tggactccgc
     2341 gagagcgcgg atgctcgagc ccttctcgta tttcttcttc aggtcagcgg ccagcttgtc
     2401 acgcgtgttg ccggtgatcc gcgcgccttt cttgagatca gccacgtcga tcgccttccc
     2461 gccgagagtg ttctgggcca cataacggcc cctgtcgccg caatgatcga acactgagcg
     2521 ccggaatgcc agacgacgag cgcaaaactg ctgaaaccgc gatcacattg ggccatttca
     2581 gtggccggat ggcatcgatc aagcacccga acggacgcag acctcacgca agctggacaa
     2641 gttccagata atccgccgac caatggtcct cggttccgtc cggcaagagg atcacgcgct
     2701 ccggctccag cgcctcgacc gcacccgggt cgtgcgtcac caggacgacg gctcccgcga
     2761 agctgcgcaa ggcgtccagg acctgggcgc ggctggccgg gtccaggttg ttcgtcggct
     2821 cgtcgagcag caaaacgttg gcagcgctgg acaccagccc ggcgagcgcg agccgcgtct
     2881 tctcgccgcc ggagagcgtg ccggcgggct gatcgagctg ctcgccggtg aacaggaacg
     2941 aaccgagaag gttccgcaac tcctgcgctc cggtgtccgg cgcgaggtga cggatatttt
     3001 cccacacgga cgcatcgtgg tcgagagttt catgttcctg tgcgtaatag cccagacgca
     3061 atccgtgacc tggaatggtc tcgccggtat ccggagtttc cattccgccg agcagccgga
     3121 gcaatgtcgt ctttccggca ccgttcaatc cgagcacgac gaccttcgac ccgcggtcga
     3181 tggcgaggtc gactccggtg aagatctcga gcgaaccgta ggacttcgag agtccttccg
     3241 cggtgagcgg cgtccggccg cacggggcgg gctcggggaa cttgatccgg gcgaccttgt
     3301 cggcctgccg ggtctcgtcg agcgcggaga gcatctgctc ggcacggcgg gccatgttct
     3361 tggcggccac ggccttcgtc gccttggcgc ccagtttggc ggcctgctgc tgcagtgccg
     3421 acgccttctt ctcggcgttc gcgcgctcgc ggcggcgccg cttctcgtcg gtggcgcgcg
     3481 cgtcgaggta gcgctgccag cccatgttgt agaggtcgag ctcgccgcgg gtcgcgtcga
     3541 ggaaccacac cttgttgacg acgtcggcga gcagttccac gtcgtggctg atgaccacga
     3601 gaccgccgtc gtgctgcttc aggaagccgc gaagccagtt gatggagtcg gcgtcgaggt
     3661 ggttggtggg ctcgtcgagc agcaggatcg tctcggattt gccgcccgcg cccgcctcgg
     3721 cggcggcgaa caggatccgg gccagctcga cacggcgtcg ctgaccaccg gagagcgtct
     3781 gcaaagtctg ttcgagcacc ctgtcggcca ggccgaggtt ggaacagatc cgcgcggcct
     3841 cgctctcggc ggcgtaaccc ccgagggacg cgaagcgctc ttcgaggcgg ctgtagcggt
     3901 tgaccgcctt gtcgcgttcc ttctcgtccg ccagctccga catcgcggtc tgcgcctttt
     3961 ccatgttgcg cagcaaggtg tcgaggccgc gcgcggacag cacgcggtcc ttcgcggtga
     4021 cggacaggtc gccctcgcgc gggtcctgcg ggaggtagcc gagctcgccg ctgcggcgga
     4081 cctcgcccgc gtacggctcg ccctcccccg ccagcacctt gagcgaggtg gtcttgccgg
     4141 cgccgttgcg gccgaccagg ccgatacggt cgccctgctg gatgcggacg ttggtgtcgt
     4201 cgagcaggat gcgcgaaccc gcgcgcagct gcaggccaga ggccgtgatc acgggaactc
     4261 ccggtaaaag gggtggatga gcggacagct tcgactcgtc tgccgacggg cagacgagga
     4321 gctactccaa gaggatgtcc acgcgatcag tgtacgggcc ggtgtcgaac ggttttatcc
     4381 gaccgtgccc gacgtcacgg cccggagagg gtgatctgga ccgcgacagc ccgctccgcc
     4441 gcgtcttcca gcacggtgcg gcgcggttcg gcgatgtcga gaacgcgggc ctcggcaagc
     4501 tggaacaacg gcgcgagacg gttgtcctcg cgcagggacg ccagggcgcg gcggtcaccg
     4561 ccgagtacga cggcgtccac ttcggacagg tgcgggacga gcacctcgaa cgcgtcgtcc
     4621 gcggcggacc ggagcgccga gcgcgcttgt ccttcccgcc gccgcgagaa ccgttgctga
     4681 gaccagccgc ccgcagcgga cctgccctgg acgagatgcc ggtccgtcct ggactggacg
     4741 accactcccc cgcgcgcgat cccgacactg tgcccgccgc ggcgcaccag caggagcgcg
     4801 atcctccgcg agatcagcgc gtgctcgacg agcgggccga cggcaagacc cggcacggtc
     4861 gcttcggcgt tcagcggtcc gaaagggacg gtcgcgacgg cgacgacgcc gttgtccgcg
     4921 acgaccgtga cggtgtccgg gctcagctcg gtctcgcgga cgccttcgtt gcggacggcg
     4981 aagcgggcgt accagccttc gaggcgatcc ggcgcgacct cgaccgcccg tcccccgcct
     5041 gctacctgcc gcaccctcgc catgggtcca acgtacgggg cgtggcgcgg atcagcaggg
     5101 gtcggtcgtt gccgtttcgc ggcgacgacc cggctgccgg ggttgcgaaa gcactttcac
     5161 aacacccgcc gcggctgggg cacgtgagcg cgacgctccc gatcggtggt gtcgcgaaag
     5221 ccactttcgc gacaccgccc ggccccgacg cgcgtgaagg tcccctttcc tcagccgagg
     5281 aaaggggacc ttcacggacc acaagagagg ctagaccggc ttcaccgggc cgcgccccac
     5341 cgacttcccg acacccgcgg gccgctccgc caccccgggc tgaacgaaac cgttgatgtg
     5401 caaggagatg gcgcggatcg acccggtgtc gccaccggcg acgtccaccg cggtgaactt
     5461 ccaggtgccg tcggcggaac cggcggccag gccgccgaac gcctgcgccg gcttgtaggt
     5521 gccggtgaac ggcgcgttca ccgcgctcac cgaactgaac gcggtggccg cgttgtcggc
     5581 gaagacgacc tggcaaaggt tgttgcccga gccgccgctg cgctggaaca cggtcgcctt
     5641 cgcacccgag ggcgacgtca gcgtgccgac caggtcaccg acgtacgagt ggttgatgcc
     5701 caccgtcgtc gaggtctggt ccgcgttgca ggtcgccccg tccaccgaga acgtcagctt
     5761 cgacgcgcgc ccgacgccgc tcaccgtgat cggcacggtc accccggtcg ggtcgctgtc
     5821 cgggatcgcc acggcgtcac cggcgtaggc gaagtcccgc gacaccggcg acggggtgcc
     5881 gaccggcagc gagaacgtgg acgtcgtcgg cgagtacgaa cccgcgaagg tcacgcgtgc
     5941 ggtcagcacc accggcaccc cgagttcctg cgtggcggga acggtgatgg tgaagtcgtt
     6001 cacgccggtc tgcccggggc tgatcgtgcc gtacgacttc gaccgcggcg ccaccgtgac
     6061 accgggggtc gggctggaga gcacgacgct ggtggacgtc gcggtgccgt caccgcggtt
     6121 ggtcaccggc agggtcacct tggcggtgtc gcccgggtcg agcgcggagc cgccgtcggc
     6181 cggggtgacc gtcggctggc ccgccgacgc gagcggctgc gggctggcgc cggtgtaggc
     6241 gagcaccttg tcggcgagga tgacgcccgc gccgctggag ttgtcgcggc ccggggcgag
     6301 gatgtcgacg gcggtgttga tcagtgcctc gcgcacctcg gccgggggca gccccgggtt
     6361 gcccgagagc accaggcccg cgatcgcggc ggcgtgcggc gcggcggccg acgtgccgta
     6421 gaacgtggtg aagccggtga cactggtcga gacgccgtcg gccgcggtga tatccggctt
     6481 ggcgcggacc tcaccaccgg tcgcggacac gttgcccggg gtgatcggcg ttccgtcggc
     6541 ctggtagaac atccgccgcg gaccgtccga agtgaaccgt tcgaccttcg tggccgcgcc
     6601 gaaggcaccg gggaacgggc cggccgggtt ggccgggtcg cccggttcga gggcacgggg
     6661 gaacgccttg gccgccggtg ccgccgcgac actgaacgcg tcccgcgcgg ccgagtggcc
     6721 gacggtcacg ccggggctgg tgtaggcctt gagaccgtcg gccgagtcgg agaaccggcc
     6781 gcgcagcgcg gacagcgaaa ggtagcggcc ttccccggag aacttgacga tggccagtcg
     6841 gagtccggcg acgcccgtgg tgtccacccg ttcgtaggcg tcctgagtgc cgctctggac
     6901 gtcctggctg aagtcgacga cgttgcccgc cgcgttcagc aggtacaggt cgtagtcgtt
     6961 gttcgaacgg cccagcgggt cggaccagaa cagcgtgacc ggcacccggc ccgacgcgct
     7021 cgagagcggc tggaagatct ggttgcccgc ggccccggcg aagttgtgcg cggtaccggc
     7081 gtatttgccg acgctcttgc cggagtcgac gaagtcgcct tcccagtggc ccgaggtgcc
     7141 gtcggtgacg ttgccttcgt tgccggccga ggagaagtac agcgcgccgt cggaggtcac
     7201 gtcgttcacg gcctgggcga tgatccagtc ctggaacggc gattccttga agtacaggac
     7261 gtcgtcgacg atgacgtcgc accccgcgtc gaaccgcagt ttgcggatgt tgtcggcgaa
     7321 actggcgtcg gagttgaacg cgctggcgaa accaagcgcc gcgttcggcg cgagatcgtg
     7381 gatgatctcg agcatcgcgg tgccctcgtc gccgtcgcct tcctggccgg ggatcacgtc
     7441 gacgcccgcc gggagttcgc cacgcgcctg cgaggtcgcg agcgagtcga taccgtcgga
     7501 cagcgcgcag atcttggtac ccacaccggt gacaccgaac tgctggcgcg cggtgtcggc
     7561 gttgtgcgcg cggtcgcctt cgctggtgac cggtccggcg gcgatcccgg cctgcccctt
     7621 ggcgtcgacg gccttcttca gctcgtccgc gatccgggcg gccttctctt ccttgctctc
     7681 ccgcttgccc gcggtggcgg gctcggcgag ctggcgggcg gtgaacgcct cgttggcggt
     7741 ctcgaccttc ttgacgtcgg cgcgggccgc gatcgccggg accgcgttca gcggaacctc
     7801 ggcgcgcacg ctgccgtacc gttcggacac cgcgcgaatc cccgcaccgg attcccgcag
     7861 tcccttgagg agttcttccg agacctggcc ccggatgtcc acgagtacgg tgccggccgc
     7921 ggagacattc gccccagacc ccagtgcggg aaccgctgag gccggcatcc gctgagcgcg
     7981 gagcttctgt tcgacgagca gtcggctgtc cactttggac tcgccggcgt tctggctctt
     8041 cttgatcgac tgcagcgcct cgatctgccg gacggtgttc gccgagaacg cctccgggga
     8101 tccgccgctt tcggccgccg cgacgggcgg gctcaccaga ccgagcgcgg tgacgagggc
     8161 cgcggtgccc gcggtcagga tcgttcttct tctcctacta gaacgggttg gacgcacgtg
     8221 cgcctccgat tcctaggcgc gtgccccgac tcacgctgac cgacgccggc gatcaccggc
     8281 tggatcaagc taagtaccgg gcgtgcaccg gcggcaggcg ccgttcgagt gacgtctgat
     8341 ggagaatttc cggattcggc ggcaggtcgt gggccgttca gcgtaatcgc gtcgtcacag
     8401 gacgaacgag tccgaccagg gctgggaagc acggcccgac aagccgtcca aaagggtcac
     8461 cgcctgcttg tccgtcagcg acgccacgaa gtcgacgacc gcccgcccgc gtgccagtcc
     8521 gcgtacggcg tcggcaccgg tgaccggttc cccggtcgct ccgatgagca gttcaggcga
     8581 ggtccgtgcg agcgcggaga actcggactg tgccaattcc accaagtcgt gcagccgccg
     8641 cgggagccgg tagaactcgt cgcggtcgag cagccacgcg tcgagcgcgt cgaccagcgt
     8701 ggtcaccagg ctggcctgtc cacgttggtg cagcgcgagt tccgggcgca gcagcacgaa
     8761 ccgccggtgc acgaatttca gcacctgaac ctcgtgccac tgggcggggc gcagcgtgag
     8821 atgccctgtc cgggtcgaag gcgacgccac cacctggacc ccatcgacga gccgcgcggt
     8881 ccacttcgag gagaaggcgg cggtggcctg ttccgcctcg atggaaccgt cgaagccggt
     8941 ggcgagcaga ccgtcgacga gttcggcgcg gacacgggcg acggcgctgg tgaaggcgtc
     9001 gtcgtcgacg atccagccgt ccttggcgtg catccggcgg cgcagccgtt ccagcgaacg
     9061 gccgggcagc cgccgttccg cggtcagggt cgcgtcgtcc agcccggcca gttccagcgc
     9121 gtggtcgacc cagccggaga actcggcggc gaccggcgcg tgctgcagga caccgatccg
     9181 gtggaagtcc tggaggtcgt ggatggcgta ggcgatgtcg tcggcggtgt ccatcacgga
     9241 cgcttcgacg gtctgctgcc agggttcgat ccggccgtcg aacggggccc gcgcctgggc
     9301 gaagtcgtcg agttcggtgc tgtaggcgga gaacttgctc gcaccggtgc cgggggcgtc
     9361 ggcgggctcg gccgcgccgc gcggctggac gggcatcgac gtcgggtgcg ggtcgggtac
     9421 gtgcaaccgc gcccacgggt acttcagcac ggcggcgcgc accgccgtgg tgaggtcgag
     9481 cccggaggcg gacgggccgc gcacgtcggt ggtggtgatg atccggaacg actgcgcgtt
     9541 gccttcgaaa ccgtcggcga ggccgaagcg gtggcgggcg atccggtcca gggtctgctc
     9601 gccgaggtgc ccgaacggcg gatgtcccag atcgtgcgcg agcgaggcgg cctcggcgac
     9661 gtccggatcg cagccgccca gtttcgcggc gagttcggcc gaatcgctgc tcgcgttgat
     9721 ccgctcggcg atggcgcgtg cgacctgcgc gaccttgagg ctgtgcgtga gccggttgtg
     9781 cagcagcccg gcgcccccgg cgctgacgac ctgggtcaca ccgccgagcc gggcgaagaa
     9841 cggcgaagcg gcgatccggt cccggtcgat ccggaacggg ctcgtggcga ggtcgctgaa
     9901 cccggcgttc gcgctctccg gatcgcgccg ccacgccctc gggtccgtct gttccatgcg
     9961 tcacacggta tccgtcgggg ctttgagaga cactgcccag gtggcggacg tggtgatcgc
    10021 gggcggcggc ccggccgggc gggcgctcgc gcgtgcctgc gcacggcgcg gtctggaaac
    10081 gaccctgatc gacccggcgc cgggccgccg ctggcgggcg acctacgggt tgttcgccga
    10141 cgagctgccc gggctgcccg gaggtgccgt cgcgtgcgcg ccttcgacga cgctcgcctt
    10201 cgggaccagg ccacacgtcc tggatcggcg ctatctggtg atggacaacg ccggcttgcg
    10261 cacgtggctc gacggtggtt acgacgtcgt cgccgggaaa gtgtccggtg tggaccacgg
    10321 cggtcaaggt tcgtccgtgc gcctcgagga cggacgaatc ctcgcgaccg gcctgtacgt
    10381 cgacgcgtcc ggtgtccggc cgcgaggcga ccggtacgaa cagacggcgt tcggtgccgt
    10441 cctcccggcc gaggacgcgc tgcggctggt ggacgacccg gacaccgccg tgttcatgga
    10501 ctggcgggag gccgagtccg gattcctgta tgtactgccg ctcggcgacg gcaccgtcct
    10561 ggtcgaggag acgtcgctgg cccgccggcc cggcctgccg ctcgacgtcc tcgcggcgcg
    10621 gttgcgagcc cggctgaagg ctgtcgggct gacgtcgcgc gggcgcgaag aacgcgtgcg
    10681 gatcgtgctc gacgcgccgg tgccgcgacg tggccggacg gtgccgttcg ggaccgccgc
    10741 cgccctggtg catccggcga ccgggtacag cgtcacgacg tcgatccggc tcgcggaaac
    10801 ggtggccgac gccgcggccg cggcttggga tcgagggccg gccgcggcgg cgtcggcggc
    10861 gcatcgggcg ctgtggccgt cctcggcacg caccgtgcac ggattgcggc ggcacgggct
    10921 gcgggcactg tgcggaatgc cgcccgaact gatcccggtg ttcttcgatc tgttcttcac
    10981 cttgcccacc tcactccagc gggcattcac gagcggtcgc gaagatgttt cgggtaacgc
    11041 cgaagcgatg tcgacgcttt tccgaatgtc gccatggaca gtaagaaaac acctgatcgg
    11101 gtggcgtgcg ttacgccgtt ctaggtaacc caggtgcctg cacgatgaac atcagttgac
    11161 acgtatttcg tttaccgccg ccagcggaga acatgcgctt gtgacgttgc agatcgctgt
    11221 ccgcttcgct taccagccgt tgtacagcct gcacaccggt ggcgtcgtcg cgttcgaagc
    11281 actggcccgg ccaggccgcg gcaccgccca cgaactgctc gccgacgccc ggcgcagcgg
    11341 caggctggcc gaggtcgacg tcggcctggc cgccgaggcc gtccggcagc tgcgtgaacc
    11401 gcaggccgcg ctccccctgc acctgaacct gtccgcacgg acggtggcgg caccgcccgc
    11461 gcatttcgac ccgctgaccg aggcgctcag cctggtgggc cgccggacca gggacgtcgt
    11521 gctggagatc gggccaccgt tcacccagat ccccgccgac ctgctgctca ccgggatgcg
    11581 acggctcacc gacctcgggt tccggctcgc gctcgacggc ctcggccgcg gcgacctccc
    11641 gctcacgctg ctcgcttcgg cgcccgtcga cctggtgaaa ctggaccgca gcgtgctgcg
    11701 tggcctgccg cacgacccgg ccgccgtcgc ggtggtcgag gcggtgctgc acttcgcgtc
    11761 acgcaccgac aaccgcctgg tcgccactgg cctcgaaacc acggagcagc tggaatccgc
    11821 gcggcggctc ggcgtgcgga tcgcgcaggg caacctgctc gccccgccgg acggcgacca
    11881 cgcgccgctg cccgcgccgg acgcgcctgg gccgttcatc cccggtaccg cccgcgcccg
    11941 ccgcgtcggc gacttcctcc ggcccgcgac cacgctgccg gaagacgcca cctgcgacga
    12001 cgtgcgcgag gtgctggccg ccgccgacgg gccgagcggc atcgtcggca tcgacgaccg
    12061 gcaccgtcca cagtggtcga tcgaccggac gcggttcctg gtcgcggtca ccgggttgta
    12121 cggccacgcc ctgcacgcca aacggccggc ttcgcggctc gccgaccggc cgcacacgat
    12181 ccacgccgac gcgagcgcgc tcgaattcct cgaactggtc accgacgcgg actggggccg
    12241 gaccggcgac gacgtcgtgg tggtcgacga ccgcggccgg tgtgtcggcg tggtgctggt
    12301 gaacgaggtc gtccgcgggg tcgcggaggc gaaggtcgaa gaggcggtct cgctgagccc
    12361 gctgacccgc ctgcccggca gcgacgcggt cgccagggac gtcgaccgcc ggatcaacgc
    12421 gcgggagccg ttcgtcgcgg cctggctgga cgtcgactcg ttcaagacgg tcaacgacac
    12481 cgccgggttc gccgcgggcg acgacctgat ccgcgcgctc ggccggaccc tcaccgacct
    12541 ggaggcccgg ctgcgccgga tgcgcgtcag ccacgtcggc ggggacgact tcctgatcgc
    12601 ctgcgacgtc gacgagatcg gcacggtcgc cgccgcgctg ctggacacgg cttggtcggc
    12661 cgacgggctg ccggtgacgg tttcgctggc gaccctggtg tgcgggcacg gcgcgatccg
    12721 gtcctacaag gacgcttccc ggctcctggc gcccctgaag aagcgggcca aagaggtccc
    12781 cgggtcgagc tgggtgctcg ggcggccggg ctcggaccgg gtcgaggtcc tgcgcgggat
    12841 cacgacgcgc ggcctgccct cacaacgcgc cgccgccggc ttttgacccc ctcccgcaat
    12901 tcgtcatcta cttgcgctct ttacgcgcgc aagtagatga cgaattgcgg gggatcagag
    12961 ggcgtaggcg gcgcggtagg ccgagaagcg ttcgtcgacc tcaccggcgg tgagcccgaa
    13021 gtccgcgagg tcgtaccggt gcacgggttt cctttccccg gaacggcttt cggcgtgcac
    13081 gacggtcatc gcgtcccggg cggcgtcgct cagcggcagc ccgaaatgcc ggtagacgcc
    13141 ctcgaccgta ccgatcgggt cggcgacgaa atcctcatac cggacatcgc agaaccgcgc
    13201 cggatcgtgc cgtttccttg cctccagcga tttttccgca ccgcgcgccc agagatccag
    13261 ctggctgcgg ccgatcacgt cgccgcggaa gacttcggac cagcccgccg aggcctgctc
    13321 attcaggctg cacaccgacg cgacgatcgt gctcggcgcg cgatgggtct ggacgatcag
    13381 cgcgtccgga tacacctcca gcaacgcgtc gagcgcgaag agatggctcg ggttcttgag
    13441 cacccaccgc cgtccggcgt cgggcaggcc gatgagctgc aggttgcgcc tatgcctgcg
    13501 ataggcgtcg gtccagctct gcccgtccag ccagcgcgag tacgagggca catgcgcgag
    13561 acattcgtag gacaccgatt tcagcgactg ccgcaggagc tgccagcatt cctccacctg
    13621 atcggcggac atgtggtgca ggcccatgaa ttcggggtgt tcgacgtggt gtttctcgta
    13681 acccgcctgg atcccttgga agaccgggtt ctccgcccag gtctcgcgcg gcggacgtgc
    13741 ttgcggcact tcggtcagcc agacttccag cccctggtgc gccggatctt cggtgagcag
    13801 ccggtgcagc gccgtggtcc ccgtgcgcgg caggccggtg acgaagatcg gccgctcgat
    13861 gggaacttcg gcgtattccg gattctgctt ccacgaggcc tcgctcaacg acctcgccac
    13921 cagtgcgccg cgcaggaacg cgcgatggat cttgttgccg tacggggtca gcccggcctc
    13981 gccggcatac gaatccagca gcacgcggag accttcgagg tggtcttcgc cgccgaagtc
    14041 gtccagcccg gtgagtttcg ccgccgacgc gtgcagatcc tccacggtgc cgacgttttc
    14101 ccgccctggc agcatgttct ccctttcagt gatggtattc gccggcgttg acgtcgaggc
    14161 actgaccggt gacacatcgg gcgagcgacg aggccaggaa cacgacggtg tcggcgatct
    14221 cgtccggttc gggcagacgg cgcaggtcga tcgtctccgc cgtctcggcg tacacctgct
    14281 ccggcggcac cccgcgttcc ttggccagat aagcgaaata ccacttcagc gagtccgccc
    14341 agatatagcc cggcgccacg gaattgaccc ggatcccccg cggcccgagt tccgaggcga
    14401 gactctgcgc gagcgcgagc aggctcgcct tcgccatctt gtacgcgccg aacgtccgcc
    14461 gggaatgccg caacacggcc gaattgatca tcaccacaga accgccgcgc tcggcgagcg
    14521 aggacgtgaa caagcgcgtg agccggagcg cggcgagcac gttggtctcg aaacccgctc
    14581 gcacgtcggc gaggtcgacc tcggcgagat ccatgatcgg cgggatggcg aaggcgttgt
    14641 tcaccaaggc gtccacccgt ccgaacgcct tcatcgcggc ctcggcgaga ttcgccgccg
    14701 aagcgtcgtc ggtgatgtcg gtgcgcacgg cgaccgcgcg acggccgagc gcgtcgacct
    14761 ccttggcgac ctccgcgagc cgggattcgg tgcgggccgc gaggacgacg tcggcgcccg
    14821 ccgcggcaca gcgcacggcg atcgaccggc cgagcccggg accgaccccg gagaccacga
    14881 tcaccttgtt gcgcaagaga tccgtcatcc cagcatcctc gccgcgacgg ccttctgacg
    14941 ggccgagatc cggtccgccc actcctgcgg ggtcacccgc gcctcgtcgt ggaacggcaa
    15001 ccggtcggcg agttcgccga acttcaccac ctcgacctcg ggaccgtcgg ccttctccag
    15061 cgcacgggac aggcgctgcc accggatttg gacgtacccg cggtcgtgcc cggtgcgttc
    15121 gagccagttc gccagtccgg gatcgcgttc gctgatcacg aagcggatct tgccgtccgg
    15181 gtcgacccgc gcctggtcgg cggtgaggct cgtctggtgg ttgatgtagt ccagcgagag
    15241 ataccagacg ctgccgagct ggatgccctg gtacggcgcg tccgatcgcg gcaccgtcac
    15301 gatcatgacc tcttcgtcgc cgagttcgta gtgcccggcc gacgagtact gcgtggtcag
    15361 gccgcccggc gtgggtcgcg gttcggtcat cgtgttcacc ggcaggttca ggtagaacca
    15421 tttcgggaag gcgaggaaag tgcggagcct gctcagcagg atcttgccgg tcacgccgta
    15481 gcgtttggcc agcccgtcac gggtgagcgg cgcgggcgcg ccacccgcgg tgtcggcgca
    15541 ctggatctgg atcgtgccgc ggcgttcggt ggcccagtcg ctgtagacct cgcgcaccac
    15601 gagcatcgac gaacccgggc cgagcacgaa gtagttgggg ccggggccgg gtttcgccgg
    15661 cccgaagcgg agttcgaacg tgccgtcctc ggctatctcg atctcgcggt cgtcgaaggc
    15721 ggcgaggctg tccggcacct cgacgggcga gtagtcgccg ttgaggacct ggaaactgac
    15781 gtcggccgtg ctcccccgcg tcccggtgac gacgtattcg cggtcctcgc ggatgttcgc
    15841 gttgaagtac aacgtgtccg ggttgtcgag gcccatcttc gtgtacgggc cggtggactg
    15901 ggtgaagaac ggatagtccc gttcgtaggc ccacgccatc tgcaaggagg cgcggatgct
    15961 gccggcgagg tagtcgtacc cctcgaccag atcctgttcg gtccggatgt gcggcgcttc
    16021 cgcgatgacc ttctcggctt cgacgatcgc gtccgcgaac ggttgagtga gcaccggcga
    16081 ctccccatac tggtacaaat acgtaccggc ttggtacgtt cctcgtacaa tcagactaga
    16141 acgcgttcta aggatgggtc aatgacccga cgctcaccgc ccaccgagcg agtcgtgcgg
    16201 ctgctcgact tcttcaccgc gcacccaggc cgtcgcatcg gcctttcgga gctcgcgcgc
    16261 gagctggacc tggcgaaacc cacctgcctc ggcatcgtga ccgagctgac ggcgggcggc
    16321 tatctggtcc gggacccgca gccggtcacg taccggctcg gcccggcgat ggtcgccgcc
    16381 ggccgcgtcg cgagcgaagg attcggcgcg agcgaggtcg cgcgccggca cctggaggag
    16441 ctgagcaggc gatacggcgc cacgtgcacg gcgtcggccg tggccgggga ccggatcgtg
    16501 atggtgcaga gcgccggccc cggccggatc aaactgggcg agacctatcc gttcgcgccg
    16561 ccggtcggcc tgatgtacgt gctatgggac tccgacgcgg cgttcgacgc ctggctcgcc
    16621 aaacccccga cggtgccggt gcggctggac gaagcacacc tgcgtcgcgt cgtcgccgaa
    16681 tgccgggagc acggttacct ggtggagagc ctgacttccg cggggcggcg gctttacgcg
    16741 ctgatggcgg gcgtcggcgc ggaggaactc ccgccggaag tgcgcggact ggtgggggaa
    16801 ctcgtctcga gcctcggcga gcgcgtctac ctcggggccg atctggagcc tcgtcgcaaa
    16861 cacgcggtga gcctgctcgc cgcgccgacg ttcgacgctt cgggacggca ggagctcgtg
    16921 ctcacccttt cggtcggcga accgatcacc ggcgccgaga tcgcacggcg gggcgcggcg
    16981 ctggtcgcca ccgccgacgc cgtcaccgcc gaatccggcg gccgccaccc ccgcaattag
    17041 ccccctggat gcgatagttg cacgcgcaag taccgcatcc agatgacgaa tcgcgggtca
    17101 gggagaccag cggttcgcgg tgagcttcag gctcggcacg tcgtccatcg acatcatcgt
    17161 ctcgtacagc cggtcgtact gggtcgaggc ggtcagccac acgccgtcca ctcgccgata
    17221 ggtgtcctcg tagtacgccg caccctcgat caccacccgg tgttcgggca cgatcacctt
    17281 gtcccgcatc agccacgtgc ccgtcgcggt gtcgccgtcg acgtcgatct ccggctgccc
    17341 ggcgaagtgc accgtcgtga tgccggggcc gaccgcgttc ctgaagaact cgacgatggc
    17401 ttcgcggctc tcgaaggtca acggtttgcc gtacgacggc gtgccgtagc gcgcgtgcgc
    17461 gtcggcggtc agggtctcgg ccatctcgtc ccacagcttg aggtcgaggc agcggaggta
    17521 gcgggctttg aggcgacgga tctcttcgag cgcgaccagg tccatgccga cagcgtcccc
    17581 cagcccttga ccaagcacaa gaacttgttc tactttcctg atctcgaacc acggaggtca
    17641 cgatggcgtc cccggcatac gagctcaccc atctcgaagc actggaagcc gaagccgtgc
    17701 acatcttccg cgaggtcgct gcgaccttcg aacgaccggc gctgctcttc tccggcggca
    17761 aggactcgat ggtgatgctc cacgtggcgg ccaaggcgtt ctggccgtcg ccgccgccgt
    17821 tcccggtgat gcacgtcgac accgggcaca acttcgacga ggtcatcgag ttccgcgacc
    17881 gcaccgtcga cgcgtacggg ctcaggctcg tcgtctccag cgtccaggac gacatcgacg
    17941 cgggccgggt cgtcgaagac ccgaaggccg gccgcaaccg tcttcagacc gccgccctgc
    18001 tccgcgggat ccgcgagcat tccttcgacg ccgtgttcgg cggagcgcgg cgcgacgagg
    18061 agaaggcccg cgcgaaggaa cgcgtgttca gcttccgcga cgagttcggc cagtgggacc
    18121 cgcgcaacca gcggccggaa ctctgggacc tctacaacgg caggcaccgc aagggcgagc
    18181 acatccgggt cttcccgctg tcgaactgga ccgaactcga catctggcag tacatcgaag
    18241 ccgagaacgt cgacctgccg tcgatctact acgcgcaccg gcgccaggtc gtccagcgag
    18301 acggcatgct gctcgcgcac acccggttcc tcaccctgta cgaaggcgaa agcccttacg
    18361 aggcaacggt tcgcttccgg accgtcggcg acgcgacctg caccggctgc gtcgagtcga
    18421 cggcgacgtc gccgggtgag gtggtcgccg aagtggcggt cagcaggctc accgaacgcg
    18481 gagcgacccg tgccgacgac cggatctccg aggcgggcat ggaagaccgg aagaaggaag
    18541 gctacttctg atgagcgctt cgctggtccg cctcgcgacc gcgggcagtg tcgacgacgg
    18601 gaagtcgacc ctgatcggcc gtctgctgtt cgattcgaag acggtgttca ccgaccagct
    18661 cgaagccatc gaacgcgtca gccgcgaccg cggtgaggcg tacccgaatc tcgcactgct
    18721 gaccgacggt ctccgcgcgg aacgcgaaca aggcatcacc atcgacgtcg cccaccgcta
    18781 cttcgccacg ccccggcgga agttcatcat cgccgacacg ccggggcacg tgcagtacac
    18841 ccggaacatg gtcacgggcg cgtccaccgc ggatctcgcg ctgatcctga tcgacgcccg
    18901 caaaggcgtg ctcgaacagt cgcggcggca cgcgttcctg gccagcctgc tgggcatccc
    18961 gcatctggtg ctgtgcgtca acaagatgga cctggtcggc tggtcccagg aacgcttcga
    19021 ggagatccgc gaggagttcc gccgcttcgc catgaaactc caggtacacg atctcacctt
    19081 cgtgccgatg tcggcgctgc acggcgacaa cgtagtacac cggggcgcca gtatgccttg
    19141 gtacgaaggg acttccctgc tgcatcacct cgaacaggtg catgtcgcct cggatcgcaa
    19201 cctcatcgac gcgcgattcc ctgtgcagta cgtgatccgg gagcacagcc gcgacttccg
    19261 cggctacgcg ggcaccgtcg cgggcggggt gttcaaaccc ggcgacgagg tcgccgtgct
    19321 gctgtccggc ttcaccacga cggtgcgcgc gatctggggc ccgggcggca ccacggtcac
    19381 cgaagccttc gcctcgcagg ccgtcacgat cgagctcgcc gacgacctcg acctcggtcg
    19441 cggtgacctg atctgccgcc ccggcaaccg gccccacacc agcagggacg tcgacgcgat
    19501 ggtgtgctgg ttctccgaac aaggagcttt gaaaacaggg aacgactacg tcgtgcggca
    19561 caccaccagg gagaccaagg ccgagatccg cgacctggac taccggctgg acgtcaccac
    19621 cctgcaccgc gacgagaccg cggaatcgtt gtcactcaac gagatcggcc ggatccggct
    19681 gcgcgcacga cagccgctgc tgttcgattc ctaccgccgc aaccgctcca ccggcggctt
    19741 cctcctcatc gacgagcatt ccggggcgac ggtcgcggcg ggcatgatca ccggcccgag
    19801 cgtgaccgcg tcgaacgtcg tctggcacac cgccgcggtc agcagagcgg aacgggcgac
    19861 acgcgggctc accgtctggc tcaccgggct ttccgcgtcc gggaaatcga gtgtggccgt
    19921 ggaactggag cggcggctgg tcgcgtccgg caggcccgcg tacctgctgg acggcgacaa
    19981 tctccggcac gggctgaacg ggaacctcgg cttcagcccc gccgatcgcg ccgagaacgt
    20041 ccgccgtgtc gccgaggtcg cgaagctgtt cgccgacgcc ggtgtggtgt cggtggtctc
    20101 cctgatcagc ccgtaccgga ccgaccgcga actcgcccgc gccgcacatg aggcggccgg
    20161 gctgccgttc ctcgaagtct tcgtcgacac cccgctcgaa gtctgcgaag accgcgaccc
    20221 caaggggatg tacgcgaagg cgagggcggg tgagatcagc gggttcaccg gggtcgacgc
    20281 tccctacgag cagccggaga acccggacct ggtgctgcgc ccggaaaacg gcgatccggc
    20341 cgcgatggcc gcgctgatcc tcgccgccct ggagtaagcc gaaatcatag tgccctgttg
    20401 agggataagg cgtgttgcga aagtggcttt cgcaacgtcg gccgacggtg agggcggtga
    20461 ccgccgtcgg cttcagcccg ccggcgtgac gaatccggtg tcgtaggcct tgatcaccgc
    20521 ttgggtccgg tcccgcgcgc cgagtttcgc gagcacgttt ccgacatgcg tcttgaccgt
    20581 ctgcacgccg aggtacagtt cgcccgcgat ttccacattg gacagtccgc ccgccatcag
    20641 ccgcagcacc tcgcattcgc gttcggtgag cccggcgccg gcgaggccgt cctgcgggcc
    20701 ccggttcgcc tgctgcgcgg ccagccgccg gatcgcggcc gggaacagga gcgactcccc
    20761 cgccgccacc gtccggatcg ccgcgacgat ctcctcgggc cgcgcccgct tcagcaggaa
    20821 gccgctcgcg ccggcgagca gggcatcgta gacgtagtcg tcgttttcga aggtggtcac
    20881 cacgatcacc ttcggcggct tgtccatagt ggacatcaga tgcgcggtcg cgcgaatgcc
    20941 gtcgaccgag ggcatccgca cgtccatcag cacgacgtcg ggccggaacc gcgagaccag
    21001 ccccggcacc tcggcgccgt cggacgcttc gcccacgacc tccaggtcgg gctcggaggc
    21061 gacgatcgcc cgcagccccg cccggatgag ctgttcgtcg tcgaccagca gcaccccgat
    21121 gctcatcg
//
