LOCUS       NZ_CP024972            24215 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2957855
            Orig. end                         :: 2982070
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24215
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="18"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24215
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24215
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14215](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14215
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(524..539)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.72"
                     /tool="antismash"
     misc_feature    1070..1084
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     gene            complement(2528..3253)
                     /locus_tag="CVV72_RS41645"
     CDS             complement(2528..3253)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (93-219). E-value:
                     2.1e-12. Score: 39.6. Matches aSDomain:
                     nrpspksdomains_CVV72_RS41645_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022072.4"
                     /locus_tag="CVV72_RS41645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SRPBCC family protein"
                     /protein_id="WP_255632672.1"
                     /transl_table=11
                     /translation="MGEQWWWGALGAVMVVSGLLTRRPGDRKWRSFAVGTVTSAGWMLV
                     ALFVIGPLVPGNVLGTTILIVIVLGVLAVPLIVRLSAVSRRRRGVSGRMTEYRHTATIE
                     MPAADLFAYLREPRNLPRYFPQMSRAEPEGGEAVHVEADVDGEHVEGDAWLKVDEANRS
                     LRWGAQGPHDYQGELSIEDAGPAAARLTVTLHSVRDADDETVQRGLEETVAALAHTVTA
                     DADVDAAEKEGGWAGHRDS"
     aSDomain        complement(2597..2974)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS41645_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.10E-12"
                     /label="CVV72_RS41645_Polyketide_cyc2.1"
                     /locus_tag="CVV72_RS41645"
                     /protein_end="219"
                     /protein_start="93"
                     /score="39.6"
                     /tool="antismash"
                     /translation="MTEYRHTATIEMPAADLFAYLREPRNLPRYFPQMSRAEPEGGEAV
                     HVEADVDGEHVEGDAWLKVDEANRSLRWGAQGPHDYQGELSIEDAGPAAARLTVTLHSV
                     RDADDETVQRGLEETVAALAHT"
     gene            complement(3283..4161)
                     /locus_tag="CVV72_RS13250"
                     /old_locus_tag="CVV72_13155"
     CDS             complement(3283..4161)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334991.1"
                     /locus_tag="CVV72_RS13250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13155"
                     /product="sucrase ferredoxin"
                     /protein_id="WP_219152726.1"
                     /transl_table=11
                     /translation="MTATPAERCADLAEAAGDPGEGTAPPAEHWLLVEHPGPWGRLALK
                     ESGIDPAAVAHLGSWAARVNGRIALVRRVARRPSTRDRPFRWFRVDARPGHEQIRTGEF
                     TGAAELSRITAAAGNVWKKPLALVCVHGRHDTCCAVRGRSLATALAAEFTEDTWECSHL
                     GGCRFAPSMVVLPHGFTFGGLRPDDAIGLFHRYSKGILDPGSLRGRSAYPPIVQAAHHH
                     ARAATGAAGIDDLRWTKTTRTGDRDWQVVFAEPDCVVYLREGRIPAGRRLTCASEPVRT
                     IRVFELVDLRY"
     misc_feature    complement(3544..3546)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4158..5441)
                     /locus_tag="CVV72_RS13255"
                     /old_locus_tag="CVV72_13160"
     CDS             complement(4158..5441)
                     /EC_number="1.14.11.47"
                     /GO_process="GO:0043687 - post-translational protein
                     modification [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020500226.1"
                     /locus_tag="CVV72_RS13255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13160"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_255632673.1"
                     /transl_table=11
                     /translation="MGRAELSEPSTGTGKSVPVPVDGRVPESVLSRLVGADTEEFAARH
                     WGRKPLLRRTGGGFGDLLDLDGVDEMLSRRGLRTPFLRLARDGAVVDSRSFTGGAGVGA
                     EIGDQVRDDRVAALFADGSTIVLQGLHRVWPAVIDFTTRLAGELGHPAQVNAYITPPSS
                     QGFSAHYDVHDVFVLQLAGRKRWKVHAPVHPSPLRDQPWSEHADAVAARARDDAPAIDE
                     VLEPGDVMYLPRGWLHSATALGDVSAHLTIGVHVITAFALVEAFTALVGSEERLRTSLP
                     LGIDVADPDRLEAHVESVREDLIAALRAVPGDAIARHVRDRTWQGNRPEPLAPVATARF
                     VLGLGDGDAVRRREGLRFRIGDTADGRIVLELPDRRLSLPAATSTALTALLDGRTWRLG
                     EIPGMDRGDQLVLVRRLLREGVLMAATA"
     gene            complement(5428..5637)
                     /locus_tag="CVV72_RS13260"
                     /old_locus_tag="CVV72_13165"
     CDS             complement(5428..5637)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334993.1"
                     /locus_tag="CVV72_RS13260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13165"
                     /product="hypothetical protein"
                     /protein_id="WP_219152727.1"
                     /transl_table=11
                     /translation="MSLNDDDISTTSGEDREGPADAGAGQGTPGEHDGGADGGAEGPAD
                     SGAGEGTPGQHDGGADGGADSGAS"
     misc_feature    complement(5598..5612)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            5836..6339
                     /locus_tag="CVV72_RS13265"
                     /old_locus_tag="CVV72_13170"
     CDS             5836..6339
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.4"
                     /locus_tag="CVV72_RS13265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13170"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_219152728.1"
                     /transl_table=11
                     /translation="MRFNSQLRVFGDLAGLAPSGRRPGASGDVLLRALEVRVISLPEET
                     SMSSPHRKTPAPILGHEHATGLLILTVTGELAATTAPLLRRHLAGNLPDHTVIDLSRVT
                     FLGVAGLQVLEAAALAGHERRRLALVTSSPTDLRILRLFGLDVRATVYPRLSDAIRAIS
                     SQVS"
     gene            complement(6325..7548)
                     /locus_tag="CVV72_RS13270"
                     /old_locus_tag="CVV72_13175"
     CDS             complement(6325..7548)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033020.1"
                     /locus_tag="CVV72_RS13270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13175"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_219152729.1"
                     /transl_table=11
                     /translation="MAVHETDVVVIGAGLAGLSAALHLHRAGVVCTVLEAGDEVGGRVR
                     TDVVDGFRLDRGFQILNPAYPAIQRLVDVDALRLGKFWRAVRVADDDRLSLLGSPLDTP
                     KALRDVAARRYLSAKDLAALGAFTARAAGGPARSIVRGRDGTTADELRAAGLSDRAVET
                     VFRPFLSGVFLEAGLNTSSRFFRLVWRSFLRSAPSLPSLGMGELPRQLARSLPVSAVRT
                     GTRVERVGNGEVRTSGGDVWAARAVIVATDGTTAASLVDGVPEPRWNGVTTWYFAPPRT
                     PLREPVIVVDARGGPILNTSVLSEVCPAYAPEGAALVSASALTPLGESEVRRELSRMYR
                     VDTSRWPLVERYEIPHALPAMSPPHDVRGEIRFGERLYVCGDHRDTSSLQGALASGGRA
                     ARAVLRDL"
     gene            complement(7583..8596)
                     /locus_tag="CVV72_RS13275"
                     /old_locus_tag="CVV72_13180"
     CDS             complement(7583..8596)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331951.1"
                     /locus_tag="CVV72_RS13275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13180"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_219153939.1"
                     /transl_table=11
                     /translation="MDLRRQVLERWPANWPVQPFREPAWARQEPTYRECSPALIDAAVK
                     RADARVAGNWFVVAASREIREDRPLGLRAGGRELVAWRGQDGALTIGPGACPHLGAPLE
                     QARVHCGELVCRWHGLRVGADRPGWTPLPSYDDGVLAWVRLDRFGGEAPTDRPVVPSRP
                     QGDTTVDAVATLTGICEPMDVVANRLDPWHGAWFHPYSFTRLRVVSAPQGNEVSDADDK
                     FVVEVTFRLAGKLGVPVIAEFTCPEPRTVLMTIVEGEGAGSVVETHATPLGPGPDGRPR
                     TAVIEATIATSERPGFAKAARIAPALRPLMRRASARLWQDDLAYAERRYALRAGHV"
     gene            complement(8666..9547)
                     /locus_tag="CVV72_RS13280"
                     /old_locus_tag="CVV72_13185"
     CDS             complement(8666..9547)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226309.1"
                     /locus_tag="CVV72_RS13280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13185"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_219152730.1"
                     /transl_table=11
                     /translation="MEVDEENGLRPTGSWTPGKVAEMLGISPVTLRTWATRYGVGPSLR
                     SERRHRRYSDVDVRRLQHMQRLIDRGIRAREAAAAAFSGAADALPDVPADRRVDELEQA
                     AEELEFASIAALLDETLDSIGAAAAWTDVLLPILRNLGGRWQRGDVCFESEWALTTEVS
                     LALQRYVARFAAAPAERGVLISCCPDERHSLPVEILRASLIEIGIPALYLGQMVPPETI
                     VGMASKLEPVLTVLWSMSVTTVDDLLCRRLQQHGFEVVVAGPGWEGLDVHGTPWVNDLA
                     GALEVVAERLKS"
     misc_feature    9927..9944
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    9928..9946
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.41"
                     /tool="antismash"
     misc_feature    9951..9967
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.32"
                     /tool="antismash"
     gene            10001..11083
                     /locus_tag="CVV72_RS13285"
                     /old_locus_tag="CVV72_13190"
     CDS             10001..11083
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331949.1"
                     /locus_tag="CVV72_RS13285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13190"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_219152731.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6e-42, bitscore:
                     142.5, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASIMAEEAPAAWLEALSGRCLTEAYGFVSARAAEYFAGHREGEL
                     AETAIPQFVAGGKFLRPKFAYVGWRCGGPESDAALRAAASLELLHCFALAQDDVMDGSP
                     LRRGRPALHVRFARWHAEQGWSGSADRFGESAATLFGDLFLVWSERMLRESGLDPAALA
                     RGWPRYDLMRAELAVGQLADLVNDARTLPSWETLLDVLRRKSGNYTVRRPLEFGAALAG
                     CGPDVLAALAEYGGLVGEAFQFRDDLLGVFGDPAVTGKPAGQDLRDRKASSVVVLAAEM
                     ADRRQRADLDGLLALPAVDDEAVARWCALITATGARERLGELIRERAEKAQAAIDPAVF
                     PRHAADSLAVLATKCTERDQ"
     gene            11080..12597
                     /gene="crtI"
                     /locus_tag="CVV72_RS13290"
                     /old_locus_tag="CVV72_13195"
     CDS             11080..12597
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016331948.1"
                     /locus_tag="CVV72_RS13290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13195"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_219152732.1"
                     /sec_met_domain="DAO (E-value: 2.2e-20, bitscore: 72.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTVPGPTNRVVVVGAGLSGLAAALHLAGRGRSVTVLERDAGPGG
                     LAGRVERKGYLLDTGPTVLTMPSILRDTFGAVGAELSEELPLTRLDPAYVARFADGSTL
                     PVHTDAAAMTDAVRDFAGPAEAAGYVRLREWLTRLYRTEFSRFIDSNIDSPLGMLRPEL
                     ARLVALGGFRRLDPRIGSFLSDERLKRVFTFQALYAGESPMRALALYAVISYMDTVGGV
                     YFPPGGVAALPRALARVAAENGVAFHYGDPVNALERNGDRVRAVRTAGGERHACDAVVL
                     TTEPPESYRLLGRKPKRPVPLRPAPSALIVHTGGPGDHPGIGHHTISFGQGWNSTFDEL
                     ITAGRRMSDPSLLITRPTATDPGLAPPGRQLFSILAPVPNLDRGPADWTAEAGPYAEEI
                     LSVARERLLPDFEPEFTEVIGPAEWADRGLVAGTPFSYAHSFSQTGPFRPRNLPRGTEN
                     VVLAGGGTVPGVGVPTVLISGRLAADRITGTPTSGARVLDLAAEANR"
     gene            12594..13556
                     /locus_tag="CVV72_RS13295"
                     /old_locus_tag="CVV72_13200"
     CDS             12594..13556
                     /EC_number="2.5.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647222.1"
                     /locus_tag="CVV72_RS13295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13200"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_219152733.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-118,
                     bitscore: 394.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 3.4e-61,
                     bitscore: 206.0, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRELDAAGIRDPRLRAAYTWCRGLNARHGRTYFLATRMLTAPQ
                     RPAVHALYGFARWLDDIVDEPDPDATPRSLAARLSEVEGRFLADLASGTSEDPLLRAVI
                     DTAARYELEERLFRAFFKSMRMDLSITDYSTRDDLDVYVHGSAEVIGLQVLPILGAVTP
                     REEAAPRAAALGKAFQLTNFLRDVAEDFARGRVYLPADELKAHDVDRERLAWCAEHGRA
                     DAPVRAAIRDQIAVTRRIYAEARPGIAMLHPVSRPCVATAATLYGEILDRIEDAGHDVF
                     AGRAKVTRRRRLGVACGALTRSLWARRRHPAPAPPAAVS"
     gene            13557..13898
                     /locus_tag="CVV72_RS13300"
                     /old_locus_tag="CVV72_13205"
     CDS             13557..13898
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225922.1"
                     /locus_tag="CVV72_RS13300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13205"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_219152734.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 2.6e-20,
                     bitscore: 71.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKFEYLIVLAACVLVTLPLELAGARVYRQPKRLARALLPVALVF
                     LVWDALAIATGVWGYAPEFMTGVHAPFAIPLEEILFFVVIPICGLLTYEMVQLSLTVAR
                     RRGERAVRR"
     misc_feature    13567..13582
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.93"
                     /tool="antismash"
     gene            13895..14215
                     /locus_tag="CVV72_RS13305"
                     /old_locus_tag="CVV72_13210"
     CDS             13895..14215
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl_fung"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033027.1"
                     /locus_tag="CVV72_RS13305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13210"
                     /product="lycopene cyclase domain-containing protein"
                     /protein_id="WP_219152735.1"
                     /sec_met_domain="Lycopene_cycl_fung (E-value: 1.9e-18,
                     bitscore: 65.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPWGYTVPAVIAVAVVVLAETFVLKTGLFRKPAYWLTMAIVFGF
                     QIPVDGWLTKLSAPIVLYAPEHVTGWRFPWDIPIEDFLFGYALVTAVLLLWERSRPHEE
                     AR"
     gene            14212..14943
                     /locus_tag="CVV72_RS13310"
                     /old_locus_tag="CVV72_13215"
     CDS             14212..14943
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225920.1"
                     /locus_tag="CVV72_RS13310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13215"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_219152736.1"
                     /transl_table=11
                     /translation="MNALARDGLPRGAVPSAFDTEARFYDRLVGANPGYHRHLLLSAQR
                     LDLPFDGNRLRLLDAGCGTGASTAALVSMAPGARITAFDASREMLARARSKTWPEGVEF
                     VHTPVEELAGVEGPFDAILAAYLLRNVADPTGQLRRLRGLLRPGGRIAVHEYSVRDSRR
                     ARWVWNAVCAAVIIPLGKVTTGDATLYRHLRRSVVEFDGISSLTRRLIDAGFTDVHTAT
                     VPGWQRDIVHTVVGTAPRETS"
     gene            14940..16508
                     /locus_tag="CVV72_RS13315"
                     /old_locus_tag="CVV72_13220"
     CDS             14940..16508
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006236637.1"
                     /locus_tag="CVV72_RS13315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13220"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_219152737.1"
                     /sec_met_domain="DAO (E-value: 3.2e-09, bitscore: 35.7,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSPLDRRLVTHPGRRGLADAGLLGARPTVAVVGGGIAGLTAATG
                     LAERGVTVTVFEREDHLGGRVGGWREQLPDGTPVTMSRGFHAFFRQYYNLRTLLARTDP
                     YLDRLTPLSDYPLLDAHGRIDTFAGLPRTPIWNAVVFALRSPTFTPRDLLRLSGRDALP
                     LAAVSVPETYHRLDRTDASAFLEAINFPAAARHLAFEVFSRSFFADPHDLSAAELATMF
                     HLYFLGSSEGLVFDVPTEPFPQALWDPLASYLAGRRVEIRTGTGVTALGRTPDGFEVET
                     GGRTEGFDGVVLACDVAGLRDLVTASPGIATEAWRRAIGELRTAPPFLVRRLWLDRPVD
                     ARRPPFLGTGSVPPLDNISLLDRYEGEARRWATRTGGSVVELHAYAAATADHSALEKAL
                     EQRLHEIYPETRDARVLGESTLWREDCPLFGVGDFARRPAVRTPDPLLALAGDGIRIDL
                     PVALMERAAATGWAAANTLLGHWGLAGHALRSVPNRGRIGLLNRLAASKYLAEDRRRRV
                     GGATS"
     gene            complement(16572..17042)
                     /locus_tag="CVV72_RS13320"
                     /old_locus_tag="CVV72_13225"
     CDS             complement(16572..17042)
                     /NRPS_PKS="Domain: Polyketide_cyc (9-125). E-value:
                     3.3e-20. Score: 64.6. Matches aSDomain:
                     nrpspksdomains_CVV72_RS13320_Polyketide_cyc.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005158832.1"
                     /locus_tag="CVV72_RS13320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13225"
                     /product="SRPBCC family protein"
                     /protein_id="WP_219152738.1"
                     /transl_table=11
                     /translation="MGTITKTVDVEADVTTVYNQWTQFAEFPRFMEGVDRVEQRDDTHT
                     HWTVTIAGVSREFDATITEQHPDERVAWQSDTGPNHAGVVTVHRIDDKHSRVTVQMDID
                     PEGFVENVADKLGVLDRRVQGDLDRFKTFLENRDGTETGAWRGDVERPAQHG"
     aSDomain        complement(16668..17015)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS13320_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="3.30E-20"
                     /label="CVV72_RS13320_Polyketide_cyc.1"
                     /locus_tag="CVV72_RS13320"
                     /protein_end="125"
                     /protein_start="9"
                     /score="64.6"
                     /tool="antismash"
                     /translation="VEADVTTVYNQWTQFAEFPRFMEGVDRVEQRDDTHTHWTVTIAGV
                     SREFDATITEQHPDERVAWQSDTGPNHAGVVTVHRIDDKHSRVTVQMDIDPEGFVENVA
                     DKLGVLDRRVQG"
     gene            complement(17134..18630)
                     /locus_tag="CVV72_RS13325"
                     /old_locus_tag="CVV72_13230"
     CDS             complement(17134..18630)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007034107.1"
                     /locus_tag="CVV72_RS13325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13230"
                     /product="cryptochrome/photolyase family protein"
                     /protein_id="WP_219152739.1"
                     /transl_table=11
                     /translation="MSSPPALWLFGDQLGPHFHSTPEHRDREVLLIRSAAAFGRRRFHR
                     QKLHLVEAGMRRLVADLGGRARIVDAPTYTDGLRRFGKPVVVHEPGSHAADALVRRLRE
                     QGIVADILPTPGFVLSKQDFSTWISGRRRYLMEDFYRDQRRRFGILLEPDGEPAGGKWN
                     YDHDNRRPPPGRSTLPVPAPWHPKENAIDQEVRADLDRAEGEGAIHPVGVDGPRRFAVG
                     HAEAVRALRRFLDHRLATFGPHQDAMLHADWAMSHALLSVPLNHGLLDPLDVVRKAEER
                     YRDGTAPLASVEGFVRQVLGWREWVWHLYWHLGPAYSDRNVLRAHEKPPSWWRELDADA
                     VEAACLRSALTGVRDRGYAHHIERLMVLGNHALQRAYDPAELTDWFATAFVDGFPWVMP
                     ANVIGMSQYADGGIVATKPYAAGGAYINRMSDHCGGCVFDPKKRVGASACPFTAGYWAF
                     LDRNAKRLEGNPRMRQPLNGVKRLSDLSAVVAQESDRRGF"
     gene            complement(18627..19067)
                     /locus_tag="CVV72_RS13330"
                     /old_locus_tag="CVV72_13235"
     CDS             complement(18627..19067)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (0-141). E-value:
                     2.6e-15. Score: 49.0. Matches aSDomain:
                     nrpspksdomains_CVV72_RS13330_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226310.1"
                     /locus_tag="CVV72_RS13330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13235"
                     /product="SRPBCC family protein"
                     /protein_id="WP_219152740.1"
                     /transl_table=11
                     /translation="MIHVERSLTVATPAPLVAAYLADFAHAVEWDPGTVSCVRVDDGEI
                     DVGTRWRNVSEFRGKRTELTYRLTRLDPGRITLVGQNRTATSTDDFTLHSGPAATTVRY
                     QATIVFHGLAKLASPFLKREFERLGDEVAPELAARLEQLGPG"
     aSDomain        complement(18645..19067)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS13330_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.60E-15"
                     /label="CVV72_RS13330_Polyketide_cyc2.1"
                     /locus_tag="CVV72_RS13330"
                     /protein_end="141"
                     /protein_start="0"
                     /score="49.0"
                     /tool="antismash"
                     /translation="MIHVERSLTVATPAPLVAAYLADFAHAVEWDPGTVSCVRVDDGEI
                     DVGTRWRNVSEFRGKRTELTYRLTRLDPGRITLVGQNRTATSTDDFTLHSGPAATTVRY
                     QATIVFHGLAKLASPFLKREFERLGDEVAPELAARLE"
     gene            complement(19081..19566)
                     /locus_tag="CVV72_RS13335"
                     /old_locus_tag="CVV72_13240"
     CDS             complement(19081..19566)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800526.1"
                     /locus_tag="CVV72_RS13335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13240"
                     /product="TspO/MBR family protein"
                     /protein_id="WP_219152741.1"
                     /transl_table=11
                     /translation="MTTAGLRPRRIPAPVALAGFLAVVAAVAVTGALAATQAKTVYSGL
                     VLPAWAPPSWLFGPVWTVLYLMIAVSGWLYWRARGDRRGLGWYAAGLLLNAAWTPLFFA
                     AGAYTAALADIIALDVVIVVTVLVFRRKSPLAAALQVPYLAWTLFATALNAAILVLN"
     gene            complement(19755..20291)
                     /locus_tag="CVV72_RS13340"
                     /old_locus_tag="CVV72_13245"
     CDS             complement(19755..20291)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS13340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_13245"
                     /product="hypothetical protein"
                     /protein_id="WP_219152742.1"
                     /transl_table=11
                     /translation="MTAMLGLSMAPSAIAAPGPAGEGGAGTFASVVIAAKRVPVDNRFI
                     PPRVGGDAEFNGHGPDVFASATLVGIGSNRLGVRIFMDAIETTPDFTRARGTSPDFLIY
                     VAPAGHCVLSVSRGGYEEIRYRDTDHAVDAFAGQVTDSFVSGWSFVGDTNSSEAGTRTG
                     VALTTFSFVANVQPC"
     gene            20593..23430
                     /locus_tag="CVV72_RS13345"
                     /old_locus_tag="CVV72_13250"
     CDS             20593..23430
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="CVV72_RS13345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_13250"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_219152743.1"
                     /transl_table=11
                     /translation="MDEVEGAPPRGAWTVGVLGPLEVAVNGHVFEDLGGPRLRIVLALL
                     AADAGRAVSVAALVEGLWRAQAPPDAARTARTYVSRLRGTLRRTHSGADDLIVTRPPGY
                     ALRVGPDMLDSARFERLAAAGRRALDAGHADTAADRLAAALALWRGDAYGEFTGIAALH
                     AEGERLERLRLTTVQDRIEADLATGSGEMLIAELEGLLARHPEYERLWGQLMTALYRAG
                     RQADALRAYQRAREVLVEGSGLDPSAGLAGIHRQILAQDSRLFHPRTAEPVHAPETRPA
                     QLPPAVRAFTGRSGALAELDAILPGKTAPVVIVVVSGTAGVGKSALAVHWAHRVAARFP
                     DGQLYVNLRGFDTAGSPLDPADALRRFLTALGVPEVRLPVDRDALTGLYRSVLTGKQVL
                     LVLDNAGDVEQIRPLLPGSPGCLVLVTSRHRFTSLLAVEGAHALDVGLLPRNEARDLLA
                     RRLGQERVEREPLAVTAIIDGCARLPLALAIVAARATSRPGLRLASLVNQLRDMTSALD
                     TLRGGDPATDIRAVFSWSYRALSPSATRMFRLLSRHPGSDIGTAAAASLAGSPLRQALE
                     QLAELTGANLLTEHAPGRYSFHDLLRTYAGERADDSAAEDPPHRVLHRLLDHYVHTAHA
                     ASLRLHPHRARPFTLTTPESGTTVEQPADLEQALAWFTVEHPALLAAIDLAVGIGADAS
                     GSRLAWSLSTFLERQGHWHELAAIQRTAIAAAGRLGDRRAQAHAHNDLAGAEIRLGLYD
                     DAHSTLRYALALFDQLGDQVGRAHTHLDLAWMFERQSRHTDALGHATRALDLFTTAGHH
                     DGRARALNQVGWCHSQLDNHRQALSHCRQALALHRKLGDQAGEAHTWDSLGHAHLHLGA
                     TRQATTCYQHALRLFRQLGDLYNQAGTLTHLGDTHHAADDTDAARTTWNHAITILGDLD
                     HPDADRVPRSSRSLT"
     misc_feature    20704..20706
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    22090..22092
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    23447..23461
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 24.03"
                     /tool="antismash"
     gene            23549..23860
                     /locus_tag="CVV72_RS13350"
                     /old_locus_tag="CVV72_13255"
     CDS             23549..23860
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS13350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_13255"
                     /product="hypothetical protein"
                     /protein_id="WP_219152744.1"
                     /transl_table=11
                     /translation="MPEGQKPAPSFWGPMGRVAGFLFGAGLTVLAVLTMTGDIAFVNGA
                     GEPTTGIFTRILLGLVYGVLGLASAGVAIAGFREGSHSSNGHADRDSDSDGDGDADFD"
     gene            complement(23996..24199)
                     /locus_tag="CVV72_RS13355"
                     /old_locus_tag="CVV72_13260"
     CDS             complement(23996..24199)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS13355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_13260"
                     /product="hypothetical protein"
                     /protein_id="WP_219152745.1"
                     /transl_table=11
                     /translation="MVLVTPMVIMAFALIMERVEVTVPVARPRLSVPAGSRPARQARPA
                     AVQVLAVDRAPSFEVRGSAKAA"
ORIGIN
        1 ccgcggacga tcagtggcgc ttcctgaccg tcgtgctctt cgccgagcac aagaaggacg
       61 tggaccgggt catccaggac gacgccacga aggacgaagc ggccaaggcc gctgaacggg
      121 cgaaggccgc caaggcgaac gccgtgtcgc acacgctggg atccgtgccc ccggcgcggc
      181 tggagtacct gatcaacctg aaggaccggg atttcgtcgt cgaaatctgg aagtcggtgc
      241 cccgcgacac cgaggtccac ggcgccgccg aagacgccgt cggcagcctc gaccccgccg
      301 actgggcctt cttcatcaac cagggcgccg aggaagcgca cctgcgggac atcgtcaacg
      361 agctcgccaa gcgcgaccag gagtacatcc gcctgatcac cgaactgcgc acgcgcgcgg
      421 cgaaccagct gatccggccg gcgctggtcg ccgccgcgga cgcggcactc gccgccaagc
      481 gcagcgatcg cgagaagttc cttcgtaccg gccagtacga gaacctggtc cagaccttgc
      541 gggtcgacgc gtacagcggt gtcgacgtct acctcaccga ccgcaacggc gacgtggtgc
      601 tcgaacagtg gcagccgggc gagcgcccgg aggcgcgatg gaggatcgag ccggggttga
      661 gcaatcccga gtgcttctcg ttccagtcgg tcagccgccc caaccactac ctgcgctggc
      721 gttcgggagc gtcttccgcg gcgaacacgg cgatgatccc cccgcagtcg caacgtgtgc
      781 gggcctacgt cgacccgacc gacggctcca acgccttcaa gggtgacgcg acctggtgtg
      841 tgcggggtga cgcctccagc gtctccatcc gcccttcgcg cagttcgggc aagtacctgt
      901 tcgtcaccgg cgcgatcgat gacgacgcct acgcgatcgc gacgaagtgg cacgccgagg
      961 ccccgctggc cccgcacccg atcgaccggc gctacgccgc ggagcagccg ctgcgcgaca
     1021 agctcggcaa gcctgtcggc gacttcgttc ccgaagggac ttccaacggg gtcggcctcg
     1081 gccaccggtt gtacgaacgg ggcaggctct acctcaccgc cggcaacgac gggaccaacc
     1141 agcgctacgc ggtgcaggcg gtctacaacg gaccggtcct cgacaagctc ctcgccctcg
     1201 gcgggcccgc cggagtcggc ggcgcgatga ccgaccaggt gcccaccaag gacggcaacg
     1261 gccaggtcct gcgggtcgtc aaacccacga tgggcgggcc gcacctccac atcgtgtgga
     1321 gcgcgtcgac gggggtccac atcgtcttcg gcctgatcgg ggagatctgg gcgaattcgg
     1381 gcggggaaac gggtccctac ggctacccgc tctccgacga gggcaccgtc agtggcacga
     1441 acgtccgcta caaccggttc gccgcgggca ccatctacta cgtgcccggt agcgcgatcc
     1501 ggcaggtcaa gggtgagatc caccggaagt tcgccgccat gggcttcgag gcgggcatgg
     1561 gttaccccct ggcggacgcc ggcacctacg gccccgacgc cggccccatg cagcgcttca
     1621 cgtcgggctc ggtgtacatc acccgcaacg gaaccgtcgc gatcaacggt gacatccacc
     1681 ggaagttcgc cgagcacggt tacgagaccg gcccgctcgg gaatccgacg ggcgatatcc
     1741 ggtccacttc ggacggtgtg ggcaaggtcg ccgacttcgc caccggttcg ggttcgatct
     1801 actggcatcc cagcaccggc gcacgcctgg tctacgggag catcagtgtg aagtacaagc
     1861 agctgggggc cgagcgttcg tacctgggct acccgaagtc cgacgaaacc gccctcccca
     1921 tgggcaggcg caacctgttc cagaacggcc ggatcgactg gagcagtgag aacggctcga
     1981 ccatcgcata ccgggtcgcg gcggtccccc acaagacggt cgacctcagg ggagccaagt
     2041 cgggccgctg catccagacc gcaggcctcg tcggggaagg cgcgttgaac gatctcgccg
     2101 gcatggagct gtgggactgc gtcggcggtg tcaagcagct ttgggacgtg acccatctcg
     2161 gcaacaacgt ctacgtcctg aagaaccgcc actcggggaa gtgcctcgac ctgcggtacg
     2221 gcgaactgca caacggcaac tcgatcgtcc agtaccagtg ccacaacggg acgacgcagc
     2281 agtgggagtt caccaccacc gcggacggct cggtcgccct ccgcagcgtg cattcggcga
     2341 agatcgtcga ggccgccggt ggcgcggacc ccaacgccac cgccgtcgtc cagcaggtgg
     2401 acaccggcca ggcgcaccag cgatggaccg tccgccccta ctgatcgaag acgacgcttc
     2461 gtgaggagcc agtgcgatga cggccgcgac ccggatcagg gtcgcggccg ttccgctcct
     2521 gaggccgtca ggaatcccgg tgtcccgccc agcctccctc tttttcggcg gcgtccacat
     2581 cggcatccgc ggtgacggtg tgcgccagcg cggcaacggt ctcctcgagc ccgcgctgca
     2641 ccgtctcgtc atccgcgtcc cggacgctgt gcagggtcac cgtgagacga gccgccgcgg
     2701 gaccggcgtc ctcgatcgac aactccccct gatagtcatg cggcccttgg gctccccacc
     2761 gcagggagcg gttggcctcg tcgaccttca gccacgcgtc accttccaca tgctcgccgt
     2821 cgacgtcggc ttcgacgtgc acggcctcgc cgccttcagg ctcggcccga ctcatttgcg
     2881 ggaagtagcg aggcaggttc cgcggctctc gcaagtaggc gaacaggtcc gcggcgggca
     2941 tctcgatggt cgcggtgtgc cggtattcgg tcatgcggcc ggataccccg cgtctcctcc
     3001 gcgaaaccgc actgagccgg acgatcagcg gaaccgcgag gacacccagg acgatcacga
     3061 tcaggatcgt ggtcccgagg acgttccccg ggaccagcgg cccgatcacg aacagggcga
     3121 ccagcatcca gcccgccgac gtgaccgtcc cgacggcgaa cgatcgccat ttccggtcac
     3181 ccggccggcg tgtcagcaag ccgctgacga ccatcactgc gcccagcgcg ccccaccacc
     3241 actgctcccc catggcttcc ccaccttcct ggcggcaccc ggtcagtacc ggagatccac
     3301 caattcgaac accctgatcg ttctcacggg ttcggacgcg cacgtgagcc gcctgcccgc
     3361 cgggatccgg ccttcgcgca ggtacacgac gcagtcgggt tcggcgaaca ccacctgcca
     3421 gtccctatca ccggtacgcg tggtcttcgt ccaccggaga tcatcgattc cggcggcgcc
     3481 ggtcgcggcg cgggcgtggt ggtgagccgc ttggacgatc ggcgggtacg cggaacggcc
     3541 gcgtaaggag ccggggtcga ggatgccctt cgaataccgg tggaagagac cgatcgcgtc
     3601 gtccgggcgc aggccgccga aggtgaaacc gtgtggcagc accaccatcg agggagcgaa
     3661 ccggcagccg ccgaggtgac tgcattccca agtgtcctcg gtgaactccg cggccagcgc
     3721 ggtcgcgagc gaacggccgc gcaccgcgca gcaggtgtcg tgtctgccgt ggacgcacac
     3781 gagcgcaagg ggtttcttcc acacgttccc cgctgcggca gtgatgcggg agagttccgc
     3841 ggcgccggtg aattccccgg tccggatctg ctcgtggccg ggacgagcgt cgacccggaa
     3901 ccagcggaag ggccggtcgc gtgtggacgg acgccgggcg acacggcgca ccagggcgat
     3961 ccggccgttg acccgagccg cccaggagcc gaggtgggcg accgctgccg gatcgatccc
     4021 ggattccttg agcgcgaggc ggccccacgg gcccggatgt tcgaccagga gccagtgctc
     4081 cgcgggcggg gccgttccct ccccgggatc gcccgcggct tcggccaggt ccgcgcaccg
     4141 ttccgccggt gtcgcggtca tgcggtcgcg gccatcagca cgccttcccg gagcaggcgg
     4201 cgcacgagca cgagctgatc accgcggtcc attcccggaa tctcccccag ccgccatgtc
     4261 cttccgtcca gcagcgccgt caaggcggtc gaggtggccg ccggcaacga gaggcggcga
     4321 tccgggagtt cgaggacgat ccggccgtcc gccgtgtccc cgatccggaa gcgcaaaccc
     4381 tcacgacgcc gcacggcatc cccgtcgccg aggcccagta cgaacctggc cgtggcgaca
     4441 ggtgccagag gttccggacg attcccttgc cacgtcctgt cccggacgtg ccgggcgatg
     4501 gcgtcgccgg gcacggcccg cagggcggcg atcaggtctt cccggacgga ctcgacatgg
     4561 gcctccagcc ggtccgggtc ggcgacgtcg atccccagcg ggagcgacgt gcgcagccgt
     4621 tcctcggaac cgacgagcgc ggtgaacgct tccaccaagg cgaaggcggt gatcacgtgg
     4681 acgccgatgg tcaaatgcgc ggagacgtca ccgagcgccg tcgcggaatg gagccagccc
     4741 cggggcagat acatcacgtc gcccggctca aggacctcgt cgatggccgg agcgtcgtca
     4801 cgggcgcgcg cggcgacggc atcggcgtgc tcgctccacg gctgatcacg caaaggcgac
     4861 gggtggacgg gcgcgtgcac cttccatcgc ttgcggcctg ccagctggag cacgaagacg
     4921 tcgtgcacgt cgtagtgcgc cgagaatccc tgcgacgacg gcggagtgat gtaggcgttg
     4981 acctgcgcgg ggtggccgag ctcgccggcc aggcgcgtgg tgaagtcgat gacggccggc
     5041 cagacgcgat gcaggccctg gagcacgatg gtgctgccgt cggcgaaaag agcggcgacc
     5101 cggtcgtcac ggacctggtc gccgatctcc gcaccgacac cggctccccc ggtgaacgaa
     5161 cgggaatcga ccacggcccc gtcgcgagcc agccgcagga acggcgtccg cagcccgcgg
     5221 cgggacagca tctcgtcgac accgtccaga tcgagcagat caccgaagcc gccaccggtt
     5281 cgccgcaaca acggtttcct gccccaatgc cgggccgcga actcttcggt gtccgcaccg
     5341 accaatcgcg acaggacact ttccgggacg cggccgtcca ccggcaccgg gacgcttttc
     5401 ccggtaccgg tggacggctc gctcagctca gctcgcccca ctgtccgcgc cgccgtcggc
     5461 cccgccgtcg tgctggcccg gggtgccttc gccggcgccg gaatcggcag gcccttcggc
     5521 gccaccgtcg gccccgccgt cgtgctcgcc gggagtcccc tggccggcac cggcgtcggc
     5581 cggtccttcg cggtcctcgc cagatgtggt ggagatgtcg tcgtcgttca ggctcatgtc
     5641 gattcccttt cccatgatcc ggatgaagca gtggccggtt accccggttc ttcccggagc
     5701 acacctgcgg agaccttcac gatcggctta ccccgcagct cctggccaca aaccgattca
     5761 agaccgattc acggcgacgg aattccttgt cccgcagact gcgggggcgg ctccggcgac
     5821 gtacggtgag agcacgtgag gttcaactcg cagcttcgcg tgttcggtga ccttgccggc
     5881 ctcgcaccgt ccggccgaag accgggtgcg tccggcgacg tgctgctgcg ggcactcgaa
     5941 gtgcgcgtca tatcgcttcc cgaggagacc tccatgtcat caccgcaccg aaaaacacct
     6001 gcccccatac tggggcacga gcacgccacc ggtctgctga tcctcaccgt gaccggcgaa
     6061 ctcgccgcca ccacggcccc gctcctccgc cgacatctgg ccgggaacct ccccgatcac
     6121 acggtgatcg acctgtcccg ggtgaccttc ctcggcgtgg cggggcttca ggtgctggag
     6181 gccgccgccc tggccggtca cgagcgccgt cggctggcgt tggtcacttc gtcgccgacg
     6241 gacctcagga tcttgcggct cttcgggctc gacgtgcggg cgacggtgta tccgcgactg
     6301 tcggacgcga tccgggcaat ctcctcacag gtctcgtagc accgcgcggg cggcccggcc
     6361 gccggaggcc agcgcgccct gcagcgaact ggtgtcacgg tgatcgccgc acacgtaaag
     6421 ccgttcgccg aaccggatct cgccacggac gtcgtgcggc ggcgacatgg ccggcagcgc
     6481 gtggggaatc tcgtagcgct cgaccaacgg ccagcgcgag gtgtccacac ggtacatccg
     6541 gctcagttcc cgccgcacct ccgattcccc gagcggcgtg agcgccgagg cgctgacgag
     6601 ggccgcgcct tccggggcgt atgccgggca gacctcgctc aggaccgagg tgttgaggat
     6661 cgggccgccg cgggcgtcga ccacgatgac cggctctcgc agcggtgtgc gtggtggcgc
     6721 gaaataccaa gtcgtgacac cgttccaccg cggttcggga acgccgtcga ccaggctcgc
     6781 ggcggtcgtg ccgtccgtgg cgacgatgac cgcgcgtgcg gcccagacgt ccccgccgga
     6841 ggtgcgtacc tccccgttcc cgacgcgttc gacgcgtgtt ccggtccgca ccgcggaaac
     6901 gggcagcgac cgggcgagtt gccggggcag ttcccccatg cccagcgacg gcaacgacgg
     6961 cgcggatcgc aggaagctgc gccagacgag ccggaagaac cgtgaggagg tattcaaccc
     7021 cgcctccagg aagaccccgg acaggaacgg gcggaacacg gtttccaccg cgcggtccga
     7081 caatcccgcg gcacgcagtt cgtcggcggt cgtgccgtcg cgaccccgga cgatcgaccg
     7141 cgccggacca cccgccgccc gcgcggtgaa ggcaccgagc gcggcgaggt ccttcgccga
     7201 caaatagcgc cttgccgcga cgtcccgcag cgccttgggt gtgtcgagcg ggcttccgag
     7261 gaggctgagc cggtcgtcgt cggccacccg gaccgcgcgc cagaacttgc ccagccgcag
     7321 cgcgtcgacg tccaccaagc gctggatcgc ggggtacgcg ggattgagga tctggaaacc
     7381 gcggtccagc cggaagccgt cgacgacgtc ggtccgcacg cggccaccga cctcgtcccc
     7441 ggcctccagg acggtgcaga cgacaccggc gcggtgaagg tgcagcgcgg cggagagacc
     7501 ggcgagtccg gcaccgatca ccacgacgtc ggtttcgtgc acagccatcg gaacgctcct
     7561 cggtgtcaca tgcgacgcga gctcagacgt gtcccgctcg caaggcgtag cgtcgttccg
     7621 cgtaggcgag atcgtcctgc cacaggcgcg cggacgcccg gcgcatcaaa ggccgcagtg
     7681 ccggggcgat ccgggcggcc ttcgcgaacc ccgggcgttc ggaggtcgcg atcgtcgcct
     7741 cgatcacggc ggtgcgcgga cggccgtccg gacctggtcc gagcggggtg gcatgcgtct
     7801 ccaccacgct tccggcgccc tcgccttcga cgatggtcat cagcacggtc cggggctcgg
     7861 gacaggtgaa ttcggcgatc accggcaccc ccagcttccc ggcgagccgg aaggtcactt
     7921 cgaccacgaa cttgtcgtcc gcgtcggaga cctcgtttcc ttgcggcgcc gagacaactc
     7981 gcaaccgcgt gaacgaatac gggtggaacc aggcgccgtg ccagggatcg agccggttcg
     8041 cgacgacgtc catcggctca cagatcccgg tcagcgtcgc taccgcgtcg accgtcgtat
     8101 caccttgcgg acgggacggc acgacaggcc gatccgtcgg agcctcgccg ccgaagcgat
     8161 cgagacggac ccaggcgagg actccgtcgt cataggacgg caagggcgtc cagcccggcc
     8221 ggtcggcccc gacccgcagc ccgtgccatc ggcagaccag ctctccacaa tggacacgcg
     8281 cctgctccag cggagcgccg agatgaggac acgcgccggg cccgatggtc aaggcaccgt
     8341 cctggccacg ccaggcgacc agttccctgc cacccgcccg gaggccgagt ggcctgtcct
     8401 cacggatttc ccggctcgcc gcgacgacga accagttgcc agccacccgg gcgtcggcgc
     8461 gtttgaccgc ggcgtcgatc agcgcggggc tgcattcgcg atacgtcggc tcctgccgcg
     8521 cccaggccgg ttcccggaag ggctggaccg gccagttcgc cggccaccgc tcgagcacct
     8581 gccgcctgag atccaccaca gactctcctg tcccgcgata tccgacggaa ccatcctgtg
     8641 gcacttggag cgatctcgca acggttcaag acttcagccg ctcggcgacg acctccagcg
     8701 cgccggcgag atcgttgacc cacggggtgc cgtgcacatc gagcccttcc cagccgggcc
     8761 ccgcgacgac gacctcgaag ccgtgctgct ggagacgacg gcagagcagg tcgtcgacgg
     8821 tggtgacgga catcgaccac agcacggtca gcaccggctc cagcttcgaa gccatgccga
     8881 cgatggtctc agggggcacc atttgaccga ggtagagcgc ggggataccg atctcgatca
     8941 gcgaagcgcg aaggatctcg accggcaggc tgtgccgttc gtccggacag caggagatga
     9001 gcacgccgcg ctccgcgggc gccgcggcga agcgggcgac gtaacgctgc agcgccaggg
     9061 aaacctcggt ggtgagcgcc cattcggatt cgaagcagac gtcgccccgc tgccagcggc
     9121 caccgaggtt ccgcaggatc ggcagcagca cgtcggtcca cgcggccgcc gcgccgatcg
     9181 agtccagcgt ttcgtccagc aacgccgcga tggacgcgaa ttccagctcc tccgcggcct
     9241 gttccaattc gtccacgcgg cggtcggccg ggacgtcggg gagcgcgtcg gcggcgcctg
     9301 agaacgcggc cgcggcggcc tcgcgggcac ggataccgcg atcgatcagc cgctgcatgt
     9361 gctgaagcct gcggacgtcg acgtcggagt accggcgatg acgccgctcg gaccgcagtg
     9421 agggccccac tccgtaacgc gtggcccaag tacggagcgt gaccggggag atgcccagca
     9481 tttcggcgac cttgccgggc gtccacgaac ccgtgggccg aaggccgttc tcctcgtcga
     9541 cttccattca gtaccacgtt tccacaccca gggagccgtc gtcgccacgt gacgacggac
     9601 ggtcctcgca cagcggcatc cgtgcccgag cctacgtgct caccctcagt gacgctcgaa
     9661 cacggcaggt atggagccgt tacgaaaaag gacgctcggc ggcgccggga ccggcctgga
     9721 ggggccgatc cgcccgggca ccgccgagcg tccgaaaccc ggtccaaggg ggacaccggg
     9781 ttcccggagg tggcggggtc ccggccaccg gcgcgaggca gtcgtcttcg attcgggagc
     9841 gatccgcggt ttgatcccgg gacttccggg caccccggac tttgttgcct ggcaggcgat
     9901 accgccgagt tgcgggggtg tcacccgatc cagtagacag ggtacacccg ttgcgaaacg
     9961 gttgcgaatc gaattttcga acggcggagg gaacggtcgg atggcgtcga tcatggcgga
    10021 agaggcgccc gccgcctggc tggaagcctt gagcgggcgt tgcctcaccg aggcgtacgg
    10081 tttcgtctcg gcacgggccg ccgaatattt cgccggccac cgtgagggtg agctcgcgga
    10141 gaccgccatt ccgcagttcg tcgcgggagg gaagttcctt cgcccgaagt tcgcctacgt
    10201 ggggtggcga tgcggcgggc cggaatcgga cgcggccttg cgcgccgcgg cgagtttgga
    10261 actgctccac tgtttcgcgc tggctcagga cgacgtcatg gacggctcac cactgcgccg
    10321 cggccgcccc gcgctgcacg tccggttcgc gcggtggcac gccgaacagg ggtggagcgg
    10381 ctccgccgac cgcttcggcg aatccgcggc gaccctgttc ggtgacctct tcctggtctg
    10441 gtcggagcgg atgctccggg aatccggcct cgacccggcg gcgctggccc gcggctggcc
    10501 gcgctatgac ctgatgcgcg cggaactggc cgtcgggcag ctcgcggatc tcgtgaacga
    10561 cgccaggacg ctcccgagct gggagacact gctcgacgtc ctgcgccgga agtccggcaa
    10621 ctacaccgtc cgcaggccac tcgagttcgg cgcggcgctg gcaggatgcg gcccggacgt
    10681 cctggccgcc ctcgccgagt acggcggcct ggtcggtgag gcgttccaat tccgggacga
    10741 tctgctcggc gtcttcggcg atccggcggt caccggcaaa ccggcgggcc aggacctccg
    10801 cgatcgcaag gcttccagtg tggtggtgct cgccgccgag atggccgacc ggcggcagcg
    10861 agcggacctc gacggcctgc tcgcgctacc ggcggtggac gacgaagccg tggcccgatg
    10921 gtgcgcgctg atcacggcga ccggggcgcg ggaacgcctc ggcgagctca tccgggaacg
    10981 ggccgagaag gcccaggccg cgatcgatcc ggccgtgttc ccccggcatg ccgcggattc
    11041 tctggccgta ctggccacga aatgcacgga gcgcgaccag tgaagacggt gccagggccc
    11101 acgaaccggg tcgtcgtcgt gggagcgggg ctgtcgggac tggcggcggc cctgcacctg
    11161 gcgggccgag gacgctcggt caccgttctc gaacgcgatg ccggcccggg cggactcgcg
    11221 ggacgcgtcg agcggaaggg ctatctgctc gacaccgggc cgacggtgct caccatgcct
    11281 tcgatccttc gggacacctt cggcgccgtg ggggccgagc tgagcgagga actaccgctg
    11341 acccgtctcg acccggcgta tgtggcgcgt ttcgccgacg gcagcacgct gcccgtgcac
    11401 acggacgccg cggcgatgac ggacgcggta cgcgacttcg cgggcccggc ggaggccgcg
    11461 ggctacgtgc ggctccgcga atggctgact cgcctgtacc gcaccgaatt ctcccggttc
    11521 atcgactcga acatcgactc accgctgggc atgctccgcc cggagctggc ccggctggtg
    11581 gcgctcggtg gtttccggcg gctggatccc aggatcggct cgttcctgtc ggacgagcgg
    11641 ctgaagcggg tgttcacctt ccaggccctc tacgcgggcg agtcaccgat gcgggcgctg
    11701 gcgctctacg cggtgatttc ctatatggac accgtcggtg gcgtgtattt cccgcccggc
    11761 ggtgtggcgg cgctcccgcg ggcactcgcc cgggtcgccg cggagaacgg ggtcgccttt
    11821 cactacggcg accccgtgaa cgcgctcgaa cggaacggtg accgggtccg cgccgtccgc
    11881 accgccggtg gcgaacgcca cgcgtgtgac gccgtcgtgc tgacgaccga accgcccgag
    11941 agctatcggc ttctcggccg gaagccgaag cggcccgtcc cgctgcggcc cgcgccgtcc
    12001 gcgctgatcg tgcacaccgg aggccccggt gaccatccgg gaatcggcca ccacacgatt
    12061 tcgttcgggc agggctggaa ttcgaccttc gacgaactca tcaccgccgg acgccgcatg
    12121 agcgatccgt ccctgctgat cacccggccc accgcgaccg atccgggact cgccccaccc
    12181 ggccgtcagc tcttctcgat cctcgcgccg gtgcccaatc tcgaccgtgg cccggcggac
    12241 tggaccgccg aagccggtcc ctacgccgag gagatccttt ccgtggcccg tgaacgtctg
    12301 ctgccggatt tcgaacccga gttcaccgag gtgatcggtc ccgccgagtg ggcggaccgc
    12361 ggcctggtgg ccgggacgcc cttcagttac gcgcattcgt tcagccaaac cggcccgttc
    12421 cgcccccgga acctgccgcg cggtaccgaa aacgtcgtcc tcgccggagg cgggacggta
    12481 cccggcgtcg gggtcccgac cgtgctgatc tccggcaggc tcgccgccga ccggatcacc
    12541 gggacgccga cgagcggcgc gcgcgtgctc gacctcgccg cggaggcgaa ccgatgacca
    12601 ggcgcgaact cgacgccgcc ggtatccgcg atccgcgcct gcgcgccgcc tacacctggt
    12661 gccgcggcct caacgcccgg cacgggcgca cgtacttcct ggcgacccgc atgctgaccg
    12721 cgccgcaacg gcccgcggtc cacgcgctct acggtttcgc ccggtggctg gacgacatcg
    12781 tcgacgaacc ggatcccgat gccacgcctc ggtcactggc cgcgaggctg tccgaagtgg
    12841 agggccggtt cctcgccgat ctggcttcgg gcaccagcga ggatcccttg ctgagagccg
    12901 tgatcgacac ggcggccagg tacgagctcg aagaacgcct cttccgcgcc ttcttcaagt
    12961 cgatgcggat ggacctgagc atcacggact actccacgag agacgatctc gacgtctatg
    13021 tgcacggctc ggccgaggtg atcggcttgc aggtgctgcc catcctcggc gcggtgaccc
    13081 ctcgcgagga ggccgcgccg cgggcggccg cgctgggcaa ggcgttccag ctgaccaact
    13141 tcctccgcga cgtcgccgag gatttcgcgc gaggacgggt ctacctgccc gcggacgagc
    13201 tcaaggccca cgacgtcgac cgcgaacggc tggcctggtg cgcggagcac ggccgggccg
    13261 acgcaccggt acgggccgcg atcagggacc agatcgccgt cacccgccgg atctacgccg
    13321 aggcacggcc gggaatcgcg atgctgcatc cggtttcgcg cccctgtgtc gccaccgccg
    13381 cgaccctcta cggggagatc ctcgaccgga tcgaggacgc tggccacgac gtgttcgccg
    13441 gccgcgcgaa ggtgacccgc cgccgccggc tcggggtcgc ctgtggcgcg ctgacccgtt
    13501 ccctgtgggc acgcaggcgg catccggcgc ccgctccccc cgcggcggtg agctgagtgg
    13561 gcaagttcga atacctgatc gtcctggcgg cctgtgtcct ggtgacactg ccgctcgaac
    13621 tggccggtgc ccgcgtctac cggcaaccga aacggctcgc ccgcgccctg ctcccggtgg
    13681 cgctggtctt cctcgtctgg gacgcgctgg cgatcgccac cggggtctgg ggctacgcac
    13741 cggaattcat gaccggcgtc cacgccccgt tcgccatccc gctggaggag atcctgttct
    13801 tcgtcgtcat cccgatctgc ggcctgctca cctacgagat ggtccagctt tcgctcaccg
    13861 tggcccggcg ccgcggcgaa cgggcggtcc gccgatgatc ccctggggct acaccgttcc
    13921 ggccgtcatc gcggtggccg tggtcgtcct cgccgagacc ttcgtgctga agaccggact
    13981 gttccggaaa cccgcttact ggctcacgat ggccatcgtc ttcggcttcc agatcccggt
    14041 cgacggctgg ctgacgaagt tgtccgcgcc gatcgtcctc tacgcgcccg agcacgtcac
    14101 cggctggcgc tttccctggg acatcccgat cgaagacttc ctgttcggct acgcgctggt
    14161 gaccgccgtg ctgctgctgt gggaacggtc ccggccacac gaggaggcgc gatgaacgcc
    14221 ctggcgcgag acggcctgcc gcgcggcgcc gtgccgtcgg ccttcgacac cgaagcccgc
    14281 ttctacgacc gcctggtggg cgcgaatccc ggttatcacc ggcatctgct gctgtccgcc
    14341 cagcggctcg acctgccgtt cgacggaaac cgcctgcggc tgctcgacgc gggctgcggc
    14401 accggtgcgt ccaccgccgc gctcgtctcg atggcgcccg gagcgcggat cacggcgttc
    14461 gacgcttccc gcgaaatgct ggcgcgagcc cggagcaaga cctggccgga aggggtcgag
    14521 ttcgtccaca cgccggtgga ggagctggca ggggtggagg gcccgttcga cgccatcctg
    14581 gcggcctatc tgctgcggaa cgttgccgac cccacgggcc agttgcgccg ccttcgcggc
    14641 ctgctgcgac cgggcggccg gatagccgta cacgagtact cggtccggga ctcccggcga
    14701 gcccgctggg tctggaacgc ggtgtgcgcg gccgtgatca tccctctcgg gaaggtcacc
    14761 accggcgacg cgacgctcta ccgccacctt cgccgcagcg tcgtcgagtt cgacggaatc
    14821 agctctctca cccggcgcct catcgacgcc ggcttcaccg acgtccacac cgccaccgtc
    14881 cccggctggc aacgcgacat cgtgcacacc gtcgtcggca ccgctccccg ggagacttcg
    14941 tgacctcacc cctggaccgc cgcctggtca ctcatccggg tcggcgaggc ctcgccgacg
    15001 ccggcctgct cggcgcgcgt cccacggtgg ccgtcgtggg cggtggcatc gccgggctca
    15061 ccgcggcgac gggactggcc gaacgcggcg tcaccgtcac cgtcttcgaa cgggaagacc
    15121 acctcggagg gagagtcggc ggctggcggg aacaactgcc ggacggcaca ccggtgacga
    15181 tgagccgggg cttccacgcc ttcttccgtc agtactacaa cctccgcacc ttgctggcgc
    15241 gcacggaccc gtacctggat cggctgaccc cgctctccga ctatccgctg ctggacgctc
    15301 acggccgcat cgacaccttc gccgggctcc ctcgcacacc gatctggaac gcggtggtct
    15361 tcgccttgcg aagcccgact ttcaccccca gggaccttct tcggctcagc gggcgcgatg
    15421 ccttgccact cgccgcggtc agcgtgcccg agacctatca ccggctcgac cgcaccgacg
    15481 cctcggcctt cctcgaagcg atcaacttcc ccgccgccgc acgacatctc gcgttcgagg
    15541 tgttctcgcg cagcttcttc gccgacccgc acgacctgtc cgccgcggaa ctggcgacca
    15601 tgttccacct ctacttcctc ggttccagcg aaggactcgt cttcgacgtg ccgaccgagc
    15661 cgttcccgca ggcactctgg gatccgctcg cgagctacct ggccggccgc cgggtcgaaa
    15721 tccgcaccgg tacgggggtg accgccctcg gccggacacc ggacggtttc gaagtcgaaa
    15781 ccggtggccg cacggagggt ttcgacggag tcgtgctcgc ctgcgacgtc gccgggctcc
    15841 gcgacctcgt caccgcttcc ccgggcatcg cgaccgaggc ctggcggcgc gcgatcggtg
    15901 aactgcggac cgccccgccc ttcctcgtcc ggcggctctg gctcgaccgc ccggtcgacg
    15961 cccggcgtcc gcctttcctc ggcaccggca gcgtcccgcc gctggacaac atcagccttc
    16021 tcgaccggta cgaaggcgaa gcgcggcgct gggccacacg taccggtggg tccgtcgtcg
    16081 aactgcacgc ctacgcggcc gccaccgcgg atcacagcgc cttggagaag gccctcgaac
    16141 aacggctcca cgagatctac ccggaaaccc gggacgcgcg ggtgctcggc gagagcacgc
    16201 tgtggcgcga ggattgcccg ctgttcggtg tcggcgactt cgcccggcgg ccggccgtgc
    16261 gaacccccga cccgctcctc gcgctcgcgg gcgacggcat ccggatcgac ctgccggtcg
    16321 ctctcatgga acgcgcggcc gccaccggct gggccgcggc caacaccctc ctcgggcact
    16381 ggggtctcgc cgggcacgcg cttcgctcgg tccccaaccg cggacggatc ggcttgctga
    16441 atcggctggc cgcctcgaaa tatctcgccg aggaccggcg acggcgggtc gggggcgcga
    16501 caagctgaac ggccggcgcg aatgtgggat cggctcccac cccaagcgca ccggccgtcc
    16561 gccgcgttcg cctagccgtg ctgggcgggg cgctcgacgt cgccacgcca cgccccggtc
    16621 tcggtgccgt cccggttctc caggaaggtc ttgaagcggt cgaggtcacc ctgcacgcgg
    16681 cgatccagca cgccgagctt gtcggcgacg ttctcgacga aaccctcggg gtcgatgtcc
    16741 atctggaccg tgacgcggct gtgcttgtcg tcgatccggt gcacggtcac gacgcccgcg
    16801 tggttcgggc ccgtgtcgga ctgccacgcc acccgctcgt cgggatgctg ttcggtgatg
    16861 gtggcgtcga actccctcga cacaccggcg atggtgaccg tccaatgtgt atgggtgtcg
    16921 tcgcgctgtt caacgcggtc cacgccctcc atgaaccgcg ggaactcggc gaactgggtc
    16981 cactggttgt acacagtggt cacgtcggct tctacgtcga cggtcttggt gatcgtgccc
    17041 atggcgaagc gtcagctcct tcacgtggtc ggttggtgtt gctcggcggt tacccggcgc
    17101 ctcgcgacca caaaccgatc cgcctccgat tcgtcagaag ccccggcggt cgctctcctg
    17161 cgccaccacg gcactcaggt cggacagccg cttcactccg ttgagcggct gccgcatccg
    17221 cgggtttcct tccaggcgtt tcgcgttgcg gtcgagaaaa gcccaatacc cggcggtgaa
    17281 cgggcaggcc gacgcgccga cgcgtttctt cgggtcgaac acgcatccgc cgcagtggtc
    17341 gctcatccgg ttgatgtacg cgccgcccgc cgcgtaaggc ttggtcgcga cgatgccgcc
    17401 gtcggcgtac tggctcatcc cgatgacgtt cgcgggcatc acccagggga aaccgtcgac
    17461 gaaggcggtg gcgaaccagt ccgtcagctc cgccggatcg taggcgcgct gcagagcgtg
    17521 attgcccagc accatgagcc gttcgatgtg gtgggcatac ccccggtcac ggacgcctgt
    17581 cagcgcggac cgcaggcagg cggcctcgac cgcgtcggcg tccagctccc gccaccatga
    17641 cggcggcttt tcgtgcgccc ggagcacgtt gcggtccgag taagccggcc cgagatgcca
    17701 gtagagatgc cacacccatt cccgccagcc gaggacttgg cggacgaagc cttcgacgct
    17761 cgccaatggt gccgtcccgt cccggtagcg ttcttctgct ttccggacga cgtcgagcgg
    17821 gtcgagcagg ccgtgattga gcggtaccga gagcagggcg tgcgacatcg cccagtccgc
    17881 gtggagcatg gcgtcctgat gcggcccgaa cgtggccagc cggtgatcga gaaagcggcg
    17941 cagggcacgg acggcctcgg cgtggccgac cgcgaaccgg cgtgggccgt cgacgccgac
    18001 cgggtgaatc gccccctcgc cttccgcgcg atcgaggtcg gccctgacct cctgatcgat
    18061 cgcgttttcc ttcgggtgcc acggcgcggg caccggcagc gtcgaccggc cggggggcgg
    18121 gcggcggttg tcgtggtcgt agttccactt tccgcctgcc ggctcaccgt ccggctcgag
    18181 caggattccg aagcggcgcc gctggtcgcg gtagaagtct tccatcaggt agcggcgacg
    18241 gcccgagatc caggtcgaga agtcctgttt ggacagaacg aagcccggcg tcggcaggat
    18301 gtccgccacg atgccctgtt cgcggagtcg cctgacgagc gcgtcggcgg cgtgtgagcc
    18361 gggttcgtgc accaccaccg gcttgccgaa gcggcgcagg ccgtcggtgt aggtcggcgc
    18421 gtcgacgatc ctggccctgc cgcccagatc cgcgaccagc cgccgcatcc cggcttcgac
    18481 caggtgcagt ttctgccggt ggaaccggcg gcgcccgaag gccgcggccg agcggatcag
    18541 cagcacctcg cggtcacgat gctccggtgt gctgtggaaa tgcggtccga gctggtcgcc
    18601 gaacaaccac agggcgggcg gggagctcat ccggggccga gctgttccag ccgggcggcg
    18661 agttcggggg cgacctcgtc gcccaggcgc tcgaactcgc gcttgaggaa cggggaggcg
    18721 agtttcgcca ggccgtggaa gacgatcgtg gcctgatagc gcacggtggt cgccgcggga
    18781 cccgagtgca gggtgaagtc gtcggtggag gtcgcggtgc ggttctgccc caccaaggtg
    18841 atccggccgg ggtccagcct ggtgagccga tacgtcagct cggtccgctt gccacggaac
    18901 tccgagacgt tgcgccaccg cgtgccgacg tcgatctcgc cgtcgtcgac acggacacag
    18961 gacacggtgc cgggatccca ctcgaccgcg tgcgcgaaat cggcgaggta cgcggcgacg
    19021 agtggtgcgg gcgtggcgac ggtgagactg cgttcgacgt ggatcatggg atctcccggc
    19081 tcaattcagg accaggatcg cggcgttgag cgccgtcgcg aacaacgtcc aggccaggta
    19141 gggcacctgc agcgcggccg cgagcgggga tttccggcgg aacaccagca cggtcacgac
    19201 gatcaccaca tccagggcga tgatgtcggc cagtgcggcg gtgtacgcgc cggcggcgaa
    19261 gaacaacggg gtccacgccg cgttgagcag caacccggcc gcgtaccagc ccagaccgcg
    19321 acggtcgccg cgtgcccgcc agtacaacca gcccgacacg gcgatcatga ggtacagaac
    19381 cgtccacacc ggaccgaaca gccacgaggg cggcgcccac gccggcagga cgagcccgct
    19441 gtacaccgtt ttcgcctgtg tcgcggccag cgcaccggtc acggcgaccg ccgcgaccac
    19501 ggcgaggaag ccggcgagtg ccaccggcgc cggaatacgg cgtggcctga gtcccgctgt
    19561 cgtcaccgct gctctccgat ctggtggccc tggggtttcc gggcaccaag tttcgttgca
    19621 caatcgattc aatggtatcc cttggctgtg cgccctcgca tctccgcggg cggcgacgtc
    19681 atccacggcc ggtcccgcac ggcggatacg tgcgggaccg gccgacggcg acgttcaccc
    19741 gactcgggac tgcctcagca cggttgtacg ttggccacga aactgaaggt ggtcagcgcg
    19801 acacccgttc tggtgcccgc ttccgaactg ttggtgtctc cgacgaagga ccagccgctg
    19861 acgaagctgt ccgtgacctg gcccgcgaac gcgtcgaccg cgtggtcggt gtcgcggtag
    19921 cggatttcct cgtaaccgcc ccggctgacg ctcaggacgc agtggcccgc cggcgccacg
    19981 tagatcagga agtcgggcga tgtcccccgc gcgcgggtga agtccggcgt cgtttcgatc
    20041 gcgtccatga agatcctgac ccccaaccgg ttcgacccga tgcccaccag cgtcgcgctg
    20101 gcgaagacgt ccggaccatg accgttgaat tcggcgtctc ccccgacccg cggtgggatg
    20161 aagcggttat ccaccggaac ccgcttggca gcgatcacca ccgacgcgaa cgtgccggct
    20221 cctccctccc cggccggtcc tggcgccgcg atggccgacg gcgccatgga caaccccagc
    20281 atggccgtca tcgcaccgat accgagcact gactttcgca tgtcgttctc tccctcatca
    20341 gtagttccag agtccggtcc ggggccggtt gccgagcggg gaactcgacc gctctcgtcc
    20401 cgaactcccc ggttcacggc cttttcctgc tcgggattca ccgtggcagt agccatcgac
    20461 aggctgtcga cacccggtcg acggtccttg gccggagggt gaccggaccg gtccgatcgg
    20521 acgacccgac gtatctggac ctcgcaccgc ggctcatgtc tcgatgagtc gaggtggagg
    20581 tgatctgtca ccgtggacga ggtcgagggg gcaccgccac gcggtgcgtg gaccgtcggg
    20641 gtgctcggcc cgctcgaagt ggccgtgaac ggtcacgtct tcgaggacct gggcggtccg
    20701 cggttacgta tcgtcctcgc gctgctggcc gccgacgccg gccgggcggt gagcgtggcg
    20761 gccttggtgg agggcctgtg gcgggcacaa gccccgccgg acgccgcccg cacggcgcgc
    20821 acctatgtct cccggctccg cgggacgttg cgccggaccc acagcggggc ggacgacttg
    20881 atcgtgacac ggcctcccgg gtatgcgctg cgcgtggggc cggacatgct ggactcggcg
    20941 cggttcgagc ggctggccgc ggccggcagg cgagccctcg acgccgggca cgcggatacc
    21001 gctgccgacc ggttggccgc ggcactggcg ctgtggcgtg gggatgccta cggcgagttc
    21061 accggtatcg cggctctgca tgccgaaggg gagcgactgg aacggctccg gctgaccacc
    21121 gtgcaggacc ggatcgaagc ggatctggcg accgggtcgg gcgagatgct gatcgcggaa
    21181 ctggaagggc tgctcgcccg ccatccggag tacgaacgac tgtggggcca gctgatgacg
    21241 gccctgtacc gggccgggcg ccaggccgac gcgctgcgcg cgtatcagcg ggcccgtgag
    21301 gtgctcgtcg aaggttccgg gctggacccc tctgccgggc tggccgggat ccatcggcag
    21361 atcctggctc aggactcccg gctgttccac ccccgcacag cagagccagt gcacgcaccc
    21421 gagacccgtc ccgcgcagtt gccgcccgcc gtgcgcgcct tcaccggccg cagcggcgcc
    21481 ctggccgaac tggacgcgat cctgccgggc aagaccgcgc cggtggtgat cgtcgtggtg
    21541 tccggcaccg ccggagtggg caaaagcgcc ttggccgtgc actgggccca tcgagtggcc
    21601 gcacggttcc ccgacgggca gctgtatgtg aacctgcgcg ggttcgacac cgccgggtca
    21661 ccgctcgacc ccgccgacgc gttgcggagg ttcctcaccg ctctcggcgt gcctgaggta
    21721 cgtctgccgg tggaccgcga cgcgctgacc ggcctgtacc gcagtgtgct gaccggcaaa
    21781 caggtgttgc tggtcttgga caacgcgggg gacgtcgagc agatccgccc gctgctgccc
    21841 ggctccccgg gctgcctggt cctggtgacc agccgccacc ggttcacttc cctgctcgcc
    21901 gtcgaagggg ctcacgcgct ggatgtcggc ctcctgcccc ggaacgaggc gcgagacctg
    21961 ctggcccgcc gtctcggcca ggagcgagtg gagcgcgaac ccctcgccgt caccgcgatc
    22021 atcgacggat gcgcgcgctt gccgctggca ctggccattg tcgccgcccg ggccaccagc
    22081 cgccccggct tacggctcgc ctcgctggtg aaccagctcc gcgacatgac gagcgcgctg
    22141 gacactctcc gcggcggcga cccggccacc gacatccggg ccgtgttctc ctggtcctat
    22201 cgcgcgttga gcccttcggc cacccggatg ttccggctgc tgagccggca ccccggttcc
    22261 gacatcggga cagcggccgc cgccagcctc gccggcagcc cgctccggca agccctggag
    22321 cagctggccg agctgaccgg agcgaacctc ctcaccgaac acgctcccgg ccggtacagc
    22381 ttccacgacc ttctccgcac ctacgcgggc gagcgggccg acgactcagc cgccgaagac
    22441 ccgccgcaca gagtgcttca ccggctgctc gatcactacg tgcacacggc gcacgccgcc
    22501 tccttgcggc tccacccgca ccgcgctcgc ccgttcaccc tgaccacgcc cgaaagcgga
    22561 accaccgttg agcaacccgc tgacctcgaa caggctctgg cgtggttcac cgtcgagcac
    22621 cccgcactgc tggccgccat cgacctggcc gtcggcatcg gggccgacgc gtccggctcc
    22681 cggttggcct ggtccctctc gacgttcctc gaacggcaag ggcactggca cgagctggcc
    22741 gccatccagc gcaccgccat cgccgccgcc ggccgactcg gcgatcgacg cgctcaagcc
    22801 cacgcccaca acgacttggc gggcgccgaa atccggttgg gcctgtacga cgacgcccac
    22861 tccactcttc ggtacgccct cgctctgttc gatcagctcg gcgaccaggt cggacgggcc
    22921 catacccacc tggacctcgc ctggatgttc gaaaggcaga gccgccacac cgacgcgctc
    22981 ggccacgcca cgcgagcact cgacctgttc acgaccgcgg gccaccacga cgggcgagcc
    23041 agagctctca accaggtcgg ctggtgccac tcccagctcg acaaccaccg gcaagccctc
    23101 tctcactgcc ggcaagccct ggccctgcac cgaaaactcg gtgaccaggc gggcgaggcg
    23161 catacctggg acagcctcgg ccacgctcac ctccatctcg gtgccacacg gcaagccacc
    23221 acctgttacc agcacgccct ccggctgttt cgccaactcg gagatctcta caaccaagcg
    23281 ggcacactca cccacctcgg cgacacccac cacgccgccg acgacaccga cgcagcccgc
    23341 accacctgga accacgccat cacgatcctc ggcgacctcg accaccctga tgccgacaga
    23401 gttccacgct cgtcccgcag cttgacctga accatccgtc cgaagtggac cgtccggccc
    23461 cggacaggga atccgaacgg cggccgcgcg tcccggtcac tccggtcagc ggtgcaccag
    23521 gcggcggagt ccgcgtagcg tcgtggccat gcctgaggga cagaagcccg ctccgagctt
    23581 ctggggcccg atgggccgtg tggccgggtt cctgttcggg gccggcctga cagtcctggc
    23641 cgtgttgacc atgacaggcg acatcgcctt cgtgaacggc gcgggtgagc ccaccaccgg
    23701 catcttcacc cgcatactgc tcgggctggt ctacggcgtc ttggggctgg cgagcgcggg
    23761 tgtcgcgatc gccggattcc gcgaagggtc gcacagcagc aacggacacg ccgaccgcga
    23821 cagtgactcc gacggggacg gcgacgccga cttcgactga aagggcggcg gcacagcggg
    23881 aatccccacg gcttcatgcg gccgaccgct ctacccgcga gcacgggcgg ctcgcgcgac
    23941 aggatctccg gagtcggagt ccacaatgga ttttcctgtg ccggcttggg atcgcctacg
    24001 ccgccttcgc gctaccccgt acttcgaacg agggcgcgcg gtcgaccgcc agcacctgaa
    24061 cggccgcggg tcgcgcctgg cgcgccggac gggagccggc cggaaccgac aggcgcggtc
    24121 tcgcgaccgg gacggtcact tcgacacgtt ccatgatcag ggcgaacgcc atgatcacca
    24181 tcggggtcac cagcaccatc cacatggatc ttgag
//
