LOCUS       NZ_CP024972            21098 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1700582
            Orig. end                         :: 1721680
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21098
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="9"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21098
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21098
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11098](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11098
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    16..30
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            342..2384
                     /locus_tag="CVV72_RS07655"
                     /old_locus_tag="CVV72_07620"
     CDS             342..2384
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029608.1"
                     /locus_tag="CVV72_RS07655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07620"
                     /product="M3 family metallopeptidase"
                     /protein_id="WP_219151704.1"
                     /transl_table=11
                     /translation="MISQDNPFAAPSELPYALPPFDRIADEHFLPAFEAGLAEHAAEIE
                     EIAGSAEPATFENTIVALEKSGRLLSRVSSVFFNLAGSNANDEIQRVQAEIAPRLAAHA
                     DAINLNPALFARINSLFERRDELGLDTESLRLLERHHTDVRRAGAGLPEADQKRLRELN
                     EQISTLSTRFQQNLLKDTNELAVVVDDVAQLAGLGEDEIATAAETAGEEGKYVLKLTLP
                     TAQAALASLEDRALRERIFTASVSRGNRGNEFDNNEIVAQLVRLRAERAAVLGFPDHAS
                     YVIEDETAKTAEAAVGLLERLAPVAVANAKAEAEELQRYLEADIPGAVLRPWDWAFYAE
                     RVRKDRFEVNTAALRPYFELNRVLTDGVFFAASNLYGLSFTEREDLPKYHPEVRIFEVF
                     DADGSELGLFLLDYYARDSKRGGAWMNNFVDQTKLLGTKTVVVNVLNVAKPPAGEPTLL
                     TFDEVVTAFHEFGHALHSLLSDVEYPMFSGTNVPRDFVEYPSQVNEMWMLWPEVLANYA
                     KHHVTGEPLPQEQIDKLLASQQYGEGFSTTEYLAASLLDQAWHALGTEDKVEDVQRFEA
                     EALTKAGVALEAVPPRYRTTYFAHIFSGGYSAGYYSYIWSEVLDADTVQWFRENGGLTR
                     ENGDHFRRELLGRGGSVDPMAAFRAFRGRDPEIEPLLKRRGLAGA"
     gene            complement(2441..3631)
                     /locus_tag="CVV72_RS07660"
                     /old_locus_tag="CVV72_07625"
     CDS             complement(2441..3631)
                     /NRPS_PKS="Domain: Aminotran_5 (21-386). E-value: 1e-56.
                     Score: 184.4. Matches aSDomain:
                     nrpspksdomains_CVV72_RS07660_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635667.1"
                     /locus_tag="CVV72_RS07660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07625"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_255632573.1"
                     /sec_met_domain="Aminotran_5 (E-value: 9.7e-49, bitscore:
                     165.1, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.1e-07,
                     bitscore: 28.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESLLDVRALRADTPGSEKVVHFNNAGCGLLAKPVLATMLDHLNL
                     EAEIGGYEAAAARSAEVEGFYREIAALINARPRNIAFAASATHAYSTALSSIRFEPGDV
                     VLTTRNDFISNQIAFLSLRKRFGVEVVHAPDSREGGVDVEAMAALMRTRKPKLVAATHI
                     PTNSGLVQPVAEIGRHCRELGLLYLVDACQSIGQYPVDVEEIGADMLTSTCRKFLRGPR
                     GSGFLFVSDRFLDAGHEPLFIDMHGARWSAPGAYEPAKSASRFEEWEFPYATVLGCAAA
                     ARYAREVGLEAISRRSPALAARLRDGLGAIPGVEVLDRGPELGALVTFSIKGWEAVPFK
                     EAMDAHRINSALSYREFAQFDFGDKNVDWCLRLSPHYYNTEREVDDVAAAVAELAA"
     aSDomain        complement(2474..3568)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS07660_Aminotran_5.1"
                     /evalue="1.00E-56"
                     /label="CVV72_RS07660_Aminotran_5.1"
                     /locus_tag="CVV72_RS07660"
                     /protein_end="386"
                     /protein_start="21"
                     /score="184.4"
                     /tool="antismash"
                     /translation="HFNNAGCGLLAKPVLATMLDHLNLEAEIGGYEAAAARSAEVEGFY
                     REIAALINARPRNIAFAASATHAYSTALSSIRFEPGDVVLTTRNDFISNQIAFLSLRKR
                     FGVEVVHAPDSREGGVDVEAMAALMRTRKPKLVAATHIPTNSGLVQPVAEIGRHCRELG
                     LLYLVDACQSIGQYPVDVEEIGADMLTSTCRKFLRGPRGSGFLFVSDRFLDAGHEPLFI
                     DMHGARWSAPGAYEPAKSASRFEEWEFPYATVLGCAAAARYAREVGLEAISRRSPALAA
                     RLRDGLGAIPGVEVLDRGPELGALVTFSIKGWEAVPFKEAMDAHRINSALSYREFAQFD
                     FGDKNVDWCLRLSPHYYNTEREVDD"
     gene            3663..5045
                     /locus_tag="CVV72_RS07665"
                     /old_locus_tag="CVV72_07630"
     CDS             3663..5045
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (161-456). E-value:
                     1.5e-24. Score: 78.7. Matches aSDomain:
                     nrpspksdomains_CVV72_RS07665_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635666.1"
                     /locus_tag="CVV72_RS07665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07630"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_219151706.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.9e-22, bitscore:
                     78.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDSSTSALVAQLRSLVRTAAAGERLPSSRELIERYRVGPGTVSR
                     AIALLAAEGIVVTRPGSGTYVAKKPSGAGEPLDTAWQTVALTDRSVDTTSLTGALGPAP
                     EDAILLDGGYPHRSLQATRFLAAALARAGRRPDAWDRAPAAGLTALRSVFAGPAGASPD
                     DVLITAGGQSGLSMAFRAIAAPGSPVLVESPTYPGALAAARAAGLRPVPVPLDGDGVRP
                     DLLAEAFAMTGARLFYCQPTFHNPTGTVLAAERRTRVLDIARAAGAFVLEDDFARHLSH
                     GATTPRPLITDDRDGTVVHLTSVTKASAPSLRIGALIARGPVLDRMKAIRQVDDFFVAR
                     PLQEAALELLSAPSWERHVRRLGAELGERCAKAAAALAAKCPEWTIARLPTGGLHLWVR
                     LPAGSDPNALARAARERGVVVGAGERFFATEPAGPFLRLSFAAAADIAELTEGIRRLDP
                     SV"
     aSDomain        4146..5030
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS07665_Aminotran_1_2.1"
                     /evalue="1.50E-24"
                     /label="CVV72_RS07665_Aminotran_1_2.1"
                     /locus_tag="CVV72_RS07665"
                     /protein_end="456"
                     /protein_start="161"
                     /score="78.7"
                     /tool="antismash"
                     /translation="PDDVLITAGGQSGLSMAFRAIAAPGSPVLVESPTYPGALAAARAA
                     GLRPVPVPLDGDGVRPDLLAEAFAMTGARLFYCQPTFHNPTGTVLAAERRTRVLDIARA
                     AGAFVLEDDFARHLSHGATTPRPLITDDRDGTVVHLTSVTKASAPSLRIGALIARGPVL
                     DRMKAIRQVDDFFVARPLQEAALELLSAPSWERHVRRLGAELGERCAKAAAALAAKCPE
                     WTIARLPTGGLHLWVRLPAGSDPNALARAARERGVVVGAGERFFATEPAGPFLRLSFAA
                     AADIAELTEGIRRL"
     gene            complement(5064..5693)
                     /locus_tag="CVV72_RS07670"
                     /old_locus_tag="CVV72_07635"
     CDS             complement(5064..5693)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334437.1"
                     /locus_tag="CVV72_RS07670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07635"
                     /product="hypothetical protein"
                     /protein_id="WP_219153860.1"
                     /transl_table=11
                     /translation="MPTLSTEAPGARRHVARIATEVLAPWVWVLGLPLVVAWKVTGHHL
                     GETVLWGLVVGVTGSLIPMAVIVRGARKGKWDSHHVTDRAGRLVPFAVCIGSLATGFAV
                     LIAGGAPHEMVALAAAELVCLVAALAITFGLKFKISMHAMVAAGAAVMLIRVHGPWLAL
                     LFLAVGWVCWSRVELGDHSKAEVVTGTGAGVVIGGGVYLFLEAVLT"
     gene            complement(5765..7564)
                     /locus_tag="CVV72_RS07675"
                     /old_locus_tag="CVV72_07640"
     CDS             complement(5765..7564)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334436.1"
                     /locus_tag="CVV72_RS07675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07640"
                     /product="right-handed parallel beta-helix
                     repeat-containing protein"
                     /protein_id="WP_219151707.1"
                     /transl_table=11
                     /translation="MPEIRFFVSTEGRDDWAGTADRPFATPRAAQKAVRAVTAGMTGDV
                     IVTFGAGVHHLAEPLVFDDTLGDSGSNGFRVIYQAEGFGTPGRAEVELSGGREITGWTE
                     GDDGVWTAPIGDLAPRRLTVEGRPVARAARTDGLPGNVTKTATGYVTDSAEPQAWPDPS
                     CLEFVYPGVYPWSEARLAVASITGDATSTTITLAQPAFDHAKSLYDSKWYGAGGDGTWD
                     GLAAPSVLENNVAFLTESGTFAVSRTDRGGHVLHYRPRPGEEIGKTRVVAPALETLIDG
                     QGVHDLVLRGFTVADAAWSGPTRTGGYLHYHGNTRYERGEFHKIDLGADVGYVHVPAEP
                     VQLPANISLTSACRVTVEGNHFTRLGAGALLIEEGTDIDVRANVFDEISGSGIAVHSAT
                     RVSLEDNLVHHIGTEYRGSPAVLVVESEETTVAHNEIHDVPHNGIVITGGERAKGTQVI
                     SNLVERSMGKLMDGGGIYLSAPQGSSFAGGAMVRGNVIRDVLTSYNFGLYADYGAAWIT
                     VLGNIVCRADTPIVLQVGPPLENVAFVGNFWDALPDGYETPPETVIVAGNTVLPKESFD
                     EASRAHPAGADILARAGRRGLER"
     gene            7653..8519
                     /locus_tag="CVV72_RS07680"
                     /old_locus_tag="CVV72_07645"
     CDS             7653..8519
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029610.1"
                     /locus_tag="CVV72_RS07680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07645"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_219151708.1"
                     /transl_table=11
                     /translation="MVEDDTQPDPERAIELLWGTSEPDRPGLSLGRIVAAAVEVADAEG
                     LAALSMRKVAERFGTTTMSLYRYVPGKAELVELMRDAVYGRFPMEPSDGLGWRAGLERW
                     ARRAWEMHRRHPWLVHSGGTRRLPGPNIMAGYDHALDVASRTGLAPAQVIAVVNLVGGF
                     VDSVARQAGETAELQRRTGVSHERWWSERESLFERLDRYPALERLWKGGGMDAPLDQFE
                     FGLQRTLDGVQAFIESQEREVMRDETGGGECASCGKPLNGGGRGRPRDYCSRACQQRAY
                     RRRQAGS"
     gene            complement(8570..8803)
                     /locus_tag="CVV72_RS07685"
                     /old_locus_tag="CVV72_07650"
     CDS             complement(8570..8803)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164761.1"
                     /locus_tag="CVV72_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07650"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_219151709.1"
                     /transl_table=11
                     /translation="MNNDSSRPTLLGLSGWWKSSYSAGANGCVEVNDSVKGYVGVRDSK
                     LGENSPVLVFEPHEIKAFVLGAKNGEFDHLLT"
     gene            complement(8793..9662)
                     /locus_tag="CVV72_RS07690"
                     /old_locus_tag="CVV72_07655"
     CDS             complement(8793..9662)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164759.1"
                     /locus_tag="CVV72_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07655"
                     /product="DUF5753 domain-containing protein"
                     /protein_id="WP_219151710.1"
                     /transl_table=11
                     /translation="MGTLTPTAIKRWIALEMKRLREAAGYDRAAAAERIGKATTVIAHI
                     ETSRNLPAPADLEVLLDFYGVPERAPFFRDLIKRAKRGRDWWINFDHGVFDWFNLYLGL
                     ETGAARISTVDLVVLPGLFQTRDYALAIMREGRRWNNKAELETMVDLRMARQEILDRPG
                     DAPHIWSILDESVLRRQVGGPAVMRDQLEHLIELSERPNIDIQVLSFTAGAHGASDGGF
                     ILLDYPSEFGGDPGTVYVENRREGLYYEDTEDLRRFRSTFERLQAQAEHPGRTRSFIQN
                     LARELNEQ"
     misc_feature    9678..9693
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(9690..9703)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.77"
                     /tool="antismash"
     misc_feature    complement(9824..9839)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            9853..9984
                     /locus_tag="CVV72_RS41525"
     CDS             9853..9984
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS41525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255632574.1"
                     /transl_table=11
                     /translation="MGEAAVVRLAPGWSGERGCPAMIEIVMVERADAIRHVYSGDNG"
     aSDomain        10001..10270
                     /aSDomain="Pantocin_Microcin_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing E1-like protein in a
                     pantocin/microcin cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_CVV72_RS07695_Pantocin_Microcin_RRE.1
                     "
                     /evalue="6.30E-21"
                     /identifier="RREFam017.1"
                     /label="CVV72_RS07695"
                     /locus_tag="CVV72_RS07695"
                     /protein_end="90"
                     /protein_start="0"
                     /score="65.3"
                     /tool="antismash"
                     /translation="MRPRIKDEHRPVRFGDGWIRIGGEVFGIAAELRDSDGAVWALLEL
                     LDGTRTVSQVVADLARLIPGTCPEEVTDAIEKLAELGYVENADEP"
     gene            10001..11098
                     /locus_tag="CVV72_RS07695"
                     /old_locus_tag="CVV72_07660"
     CDS             10001..11098
                     /GO_function="GO:0008641 - ubiquitin-like modifier
                     activating enzyme activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635656.1"
                     /locus_tag="CVV72_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07660"
                     /product="ThiF family adenylyltransferase"
                     /protein_id="WP_219151711.1"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 1.8e-18,
                     bitscore: 65.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 2.4e-46, bitscore: 156.9,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPRIKDEHRPVRFGDGWIRIGGEVFGIAAELRDSDGAVWALLEL
                     LDGTRTVSQVVADLARLIPGTCPEEVTDAIEKLAELGYVENADEPTCIALTERQLERHS
                     RSRSLYRWIDLTRRTSSWDFQVLLARARVVLVGVGGVGCTAALSLVMSGVGRLHCVEPD
                     LVELSNLGRQILYTEEHLGLPKVDVAVERLRAANSDVEVTGEATRIENAASLRRLAAGC
                     DVLIMTADHPPEIRTWTNQACAATGTPWVYGGYHGPQVNLGVYRPGAGPCYECARLAER
                     DRDAARPPLATWRPAASIPAHAANAVTAGVAGNLVAHAVMRLITNAPKLALNCQYGFSL
                     ATMDHSFVTSLERPHAECGTCLAAG"
     misc_feature    10124..10126
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11104..11976)
                     /locus_tag="CVV72_RS07700"
                     /old_locus_tag="CVV72_07665"
     CDS             complement(11104..11976)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164754.1"
                     /locus_tag="CVV72_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07665"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_219151712.1"
                     /transl_table=11
                     /translation="MPTSPPHPGSDRVRLATKLRELRAATGLSGNQFAKRLGWPQSRVS
                     KIETGVQFPTGDDITDWLTAAGADDQKDSILELLKRARVESVSFRDEFRKPGGAATKQR
                     SVLELEQRASRVATFQPALLPGLVQTPGFMRELLVLPSGPVRTGGAAEDDIERMVAIRI
                     ERQAQLHDPGKALPLVIGEAALWIRIGDLDTQLGQLDRLRSLAGLRTVDLRILPFSKAM
                     PIAPLHGFRIYDAELVVVELFAGEHLIRDPEEIALYEHMFGTLHTEALSGDAAARLIQS
                     VSRRLAEDA"
     gene            12144..12344
                     /locus_tag="CVV72_RS07705"
                     /old_locus_tag="CVV72_07670"
     CDS             12144..12344
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_07670"
                     /product="hypothetical protein"
                     /protein_id="WP_219151713.1"
                     /transl_table=11
                     /translation="MFANWIQIAELALLPLGLGIGYAAGRTCHREERASFHEEVTITHP
                     GLVAEYQRPVPDVGAGWRSAR"
     misc_feature    12502..12515
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.43"
                     /tool="antismash"
     misc_feature    12503..12516
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.0"
                     /tool="antismash"
     gene            12556..13689
                     /locus_tag="CVV72_RS07710"
                     /old_locus_tag="CVV72_07675"
     CDS             12556..13689
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164753.1"
                     /locus_tag="CVV72_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07675"
                     /product="SWIM zinc finger family protein"
                     /protein_id="WP_219151714.1"
                     /transl_table=11
                     /translation="MITEVLLEQAEEDVRTPVLFKGFLEPGAQAAQSLLVLGKVARTRF
                     WMPPSMVNRLIAESDPVFTADGTTLRAEAFSPCCGVYARLDLPDVGDLGEGCTNVDLSD
                     ATRTVLAAVVAQDPLHLTVRGEGIRIRTLDGQNDESQVPLPDRWVAGFAEVAAVTKGAV
                     ERAKLDKAETRNFLRRIPTVVGRSWAVVSGRGLRMTSRPGRDSIPATGLHRLRVIEPLI
                     RFAQGLTVYTRPDSEVSTWVLRLERARFAVTLSPEPSRGFSGEGGWLNSLAAGLEAPEL
                     VHGRAGHDVVDGTWFPRELPSGNAPANGRLAKARELVAAGAVRLLPDGGYEITRGASVQ
                     RVRLSPAGCTCAWWAKHQETRGPCSHVLAARMSSAES"
     misc_feature    12597..12612
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.34"
                     /tool="antismash"
     gene            complement(13672..16119)
                     /locus_tag="CVV72_RS07715"
                     /old_locus_tag="CVV72_07680"
     CDS             complement(13672..16119)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164751.1"
                     /locus_tag="CVV72_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07680"
                     /product="DUF6493 family protein"
                     /protein_id="WP_219151715.1"
                     /transl_table=11
                     /translation="MQLNALLTGQPSEVLTRTLELSRAERKALIPELLAAFKDSSEFIE
                     IEPNTYGARNPLRGQQAATALWAALPASDPLLRKLWIASPTILERVLQDRPLAERKTIA
                     LRMIGHQTAWEAIRRMILDGDLEPIRTPEYHAGWFRWAGRFRGEPLAQRLRTEPEALTE
                     LWELLATEGNGDASFAAFDKYVRDEDKWSTALLELTETGEIDRARLLDLTLDILARDFA
                     AFRAQWYAALHEALAPTPDERTKAQHRYARLCGSGLPRTVSFAVKALSLVDKQGTLDDE
                     VALQHLPAAAGGRGAATAGLALKLAGRIADRRPELSDLADEVFEAALTHEASGVRAVAI
                     ARLGVTPDEAPAIEAAEYPEPTRPPWDQRKTLTIPLEIPDTPAAVAEALSSLLADPDQA
                     DLLLAALDGAHRVAGELQDALKPLVKRATRITDQRYSAAVPKMIATLVLGLTGRDVTLP
                     RKVDGWRRPLHHRVAALLEGTATPVSAATHRGGWLDPVVFVSRMLDHPDAAEDDVVDGL
                     LRLAPDTRPEALTLASELTGPYADSIRYALGGPALEETGWVALAAARARHPESADPAAA
                     LRGEPGPPLTWTATTGPNDYGLISLDIESAPAAVSPKAPWLGMPFDGSAPEWLGFTECH
                     EAVASPYDRDHLEAAVAETLFSNDTEFGYPVEKTALPPFLDSPSIPGFPGTTLLAITLA
                     LKRPTAVQLGTDAVLTLLDRRLLGPRALGEAFGVLGPTLIATRLAPRLSIIANEHPVAA
                     LSTLDTLLPKLEHSHRGVFALLELAADLVERGAGTISAETKEWLTGFKGSSKAAKAASR
                     LRR"
     gene            complement(16284..17273)
                     /locus_tag="CVV72_RS07720"
                     /old_locus_tag="CVV72_07685"
     CDS             complement(16284..17273)
                     /EC_number="1.1.1.37"
                     /GO_function="GO:0016615 - malate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006108 - malate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009946856.1"
                     /locus_tag="CVV72_RS07720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07685"
                     /product="malate dehydrogenase"
                     /protein_id="WP_125787678.1"
                     /transl_table=11
                     /translation="MTQAPVNVTVTGAAGQIGYALLFRIASGQLLGPDTPVKLRLLEIP
                     QAVKAAEGTAMELEDGAFPLLSGIDIFDDPKQAFEGANVALLVGARPRAKGMERGDLLE
                     ANGGIFKPQGEAINAGAASDIKVLVVGNPANTNALIAQAHAPDVPADRFTAMTRLDHNR
                     ALAQLSKKLGVPVTELKKVAIWGNHSATQYPSIAHAEVSGKPATEVITDQQWLADDFIP
                     TVAKRGAAIIEARGLSSAASAASAAIDHVYTWVNGTPEGDWTSAAVVSDGSYGVPEGLI
                     SSFPVTAANGEYKIVQGLEIDDFSRARIDASVNELAEERDAVKKLGLI"
     misc_feature    17401..17416
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    complement(17494..17505)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.96"
                     /tool="antismash"
     misc_feature    17563..17574
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.53"
                     /tool="antismash"
     gene            17772..18353
                     /locus_tag="CVV72_RS07725"
                     /old_locus_tag="CVV72_07695"
     CDS             17772..18353
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334430.1"
                     /locus_tag="CVV72_RS07725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07695"
                     /product="DUF4360 domain-containing protein"
                     /protein_id="WP_370641950.1"
                     /transl_table=11
                     /translation="MSPPPGPPPDRVVIDVVTVNGSGCPPGSSAVAVAKDNTAFTVTYS
                     EYTAQVGVGAKPTDFRKNCQLNLNIHVPQGFTYGIASADYRGFAHLESGAKALQRANYY
                     FQGNSPTAHVSHPVNGPVSDNWQFRDEAEGGVIIYKPCGEDRNLNVNTELRVGAGSSDP
                     KKTTSFITMDSTDGAFKTTYHFSWKTCPTS"
     misc_feature    complement(18530..18541)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.72"
                     /tool="antismash"
     gene            18630..19274
                     /locus_tag="CVV72_RS07730"
                     /old_locus_tag="CVV72_07700"
     CDS             18630..19274
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159732.1"
                     /locus_tag="CVV72_RS07730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07700"
                     /product="DUF4360 domain-containing protein"
                     /protein_id="WP_219151717.1"
                     /transl_table=11
                     /translation="MLNALVAAVTLFSSTITPNAWVPPPLPSDKIVIDVVTVNGTGCRP
                     GTAAVSVSPDNTAFTVTYSEYTAQVGVGAKPTDLRKNCQLNLYVHVPQGFTYGIAGTDY
                     RGFASLAAGATGLERANYYFQGNSPTSYVNHSLKGPFEDNWQFTDNIEVGAIVYKPCGE
                     DRNFNINTELRAGVGTSDPKKTTSFVTMDSTDGSIKTTYHFSWKNCPKPKS"
     misc_feature    19385..19400
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    complement(19449..19464)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.98"
                     /tool="antismash"
     misc_feature    complement(19801..19810)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    20326..20337
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 caaggcgatc ctcgccgacg cactcggcca gcatctcgac tccttccagc ggatcgtggt
       61 cgatccggcg tcggtttcgg tcgtccggta caccgagact cgtccgttcg tgttgcgcgt
      121 caacgacaac ggcggcgacc tggccggtgt cgccccaccc gaaccgaagg ccaaagccaa
      181 gcgcggcaag ggaaaacgca gctccgacgc ggtggtgggc ggtaccaccg gagcgtgacc
      241 accgccgtcg gtggcgtcac cgccacggac ggcatccacc ggcccctcgc tgcccgtaag
      301 gtggccagac cagcagattc gacgacccgg gagcaacacc gatgatttcg caggacaacc
      361 cgttcgccgc gccgagtgag ctgccctacg cccttccgcc gttcgaccgg atcgccgacg
      421 aacacttcct tcccgccttc gaagcgggct tggccgagca cgccgccgaa atcgaggaaa
      481 tcgccggctc ggccgagccg gcgacgttcg agaacaccat cgtcgcgctc gagaaatccg
      541 gcaggttgct gtcccgcgtc tccagcgtgt tcttcaacct cgccgggtcg aacgcgaacg
      601 acgagatcca gcgtgtgcag gccgagatag caccgcgact ggccgcgcac gccgacgcca
      661 tcaacctgaa ccccgcgctg ttcgccagga tcaactccct gttcgagcgc agggacgaac
      721 tcggcctcga caccgagtcg ctgcgcctgc tggagcggca ccacaccgat gtgcgccgcg
      781 ccggcgccgg tcttcccgaa gccgaccaga agcgcctgcg tgagctgaac gagcagatct
      841 cgacgctgtc gacccggttc cagcagaacc tgctcaagga caccaacgaa ctggccgtgg
      901 tcgtcgacga cgtcgcgcaa ctcgcgggtc tcggcgagga cgagatcgcg acggccgccg
      961 aaaccgcggg cgaggagggc aagtacgtcc tcaagctgac cctgcccacg gcgcaagccg
     1021 cgctggcctc gctggaggat cgcgcgctgc gtgagcggat cttcaccgcg tcggtctccc
     1081 gcggcaaccg gggcaacgag ttcgacaaca acgagatcgt ggcccagctg gtccggttgc
     1141 gcgccgaacg ggccgccgtg ctcggtttcc ccgaccacgc ctcgtacgtc atcgaggacg
     1201 agaccgcgaa gaccgctgag gccgctgtcg gcctcctgga gcggctcgcg cccgtcgcgg
     1261 tcgccaacgc caaggcggag gccgaagagc tgcagcggta cctcgaagcc gacatccccg
     1321 gcgcggtcct gcggccgtgg gactgggcgt tctacgccga acgcgtccgc aaggaccggt
     1381 tcgaggtcaa caccgcggcg ctgcgcccgt acttcgagct gaaccgcgtg ctgaccgacg
     1441 gcgtcttctt cgccgcgtcc aacctgtacg gcctgagctt cacggagcgg gaagacctgc
     1501 cgaagtacca ccccgaggtc cggatcttcg aggtcttcga cgccgacggc tcggaactcg
     1561 gcctgttcct gctcgactac tacgcccgcg actcgaagcg cggcggcgcc tggatgaaca
     1621 acttcgtcga ccagacgaag ctgctcggta cgaagacggt cgtggtgaac gtgctcaacg
     1681 tcgccaagcc gccggcgggg gagccgaccc tgctgacctt cgacgaggtc gtcaccgcgt
     1741 tccacgagtt cgggcacgcc ctgcactcac tgctctcgga cgtcgagtac ccgatgttct
     1801 cgggcaccaa cgtcccgcgt gacttcgtcg aatatccctc gcaggtcaac gagatgtgga
     1861 tgctctggcc cgaggtcctg gccaactacg ccaagcacca cgtgaccggc gagccgttgc
     1921 cgcaggagca gatcgacaag cttctggcgt cgcagcagta cggcgaaggc ttctcgacca
     1981 ccgagtacct cgcggcgtcc ctcctcgacc aggcgtggca cgcgctggga accgaggaca
     2041 aggtcgagga cgttcagcgg ttcgaggccg aggccctgac caaggccggt gtcgcgctgg
     2101 aagccgtgcc gccgcgctac cggaccacgt acttcgcgca catcttcagc ggtggctaca
     2161 gcgccgggta ctactcctac atctggagcg aggtcctcga cgccgacacc gtccagtggt
     2221 tccgcgagaa cggcgggctc accagggaga acggcgacca cttccgccgt gaactcctcg
     2281 gccggggcgg cagcgtcgac ccgatggcgg ccttccgcgc gttccgcggc cgcgacccgg
     2341 agatcgagcc gcttctgaag cggcgcggcc tcgcgggcgc ctgacctcct gacggttcct
     2401 ccgcccggac acccccggtg tccaggcgga ggaaccgcgc tcaggcggcc agttcggcga
     2461 cggccgcggc cacgtcgtcc acttcgcgtt cggtgttgta gtagtgcggg ctcagccgca
     2521 ggcaccagtc gacgttcttg tcgccgaagt cgaactgcgc gaactcccgg tagctgagcg
     2581 ccgaattgat ccggtgggcg tccatcgcct ccttgaaggg caccgcttcc cagcctttga
     2641 tggagaacgt caccaacgcg cccaattccg ggccccggtc gagcacttcg acgcccggga
     2701 ttgcgccgag tccgtcccgc agcctcgccg cgagcgcggg actgcgccgt gagatcgcct
     2761 ccaagccgac ctcacgggcg tacctcgcgg cggcggcgca gccgagaacg gtggcgtacg
     2821 ggaattccca ctcttcgaac cgggacgcgg acttcgcggg ttcgtacgcg ccgggcgcgc
     2881 tccagcgggc accgtgcatg tcgatgaaca acggctcgtg cccggcgtcg aggaaccggt
     2941 cggagacgaa caggaacccg gaaccccgcg gaccgcgcag gaatttacga cacgtcgagg
     3001 tgagcatgtc ggcgccgatc tcttcgacgt cgacggggta ttggccgatc gactggcagg
     3061 cgtcgaccag gtagagcagg ccgagctccc ggcagtgccg cccgatctcg gcgaccggct
     3121 ggacgaggcc cgagttggtc gggatatgcg tggcggcgac cagcttcggc ttcctcgtgc
     3181 gcatcagagc cgccatcgct tcgacgtcca caccgccttc ccgcgagtcc ggcgcgtgca
     3241 cgacctcgac gccgaaccgc ttccgcagcg acaggaacgc gatctggttg gagatgaagt
     3301 cgttgcgagt ggtgagcacg acgtcgccgg gttcgaaccg gatcgacgac aacgccgtcg
     3361 aataggcgtg ggtggcactc gccgcgaagg cgatgttgcg gggcctcgcg ttgatgagcg
     3421 cggcgatttc acgatagaag ccctcgacct cggccgaacg ggcggcggcg gcttcgtagc
     3481 cgccgatttc ggcttcgaga ttcaggtgat cgagcatcgt cgcgagtacc ggcttcgcca
     3541 gcagcccgca gcccgcgttg ttgaagtgga cgaccttctc gctgcccggg gtatcggctc
     3601 ggagggcccg gacatccagt agtgattcca ccgaagagtc agtagcacta tcatgttgct
     3661 tcatgtcgga tagtagcact tccgcgctcg tcgcccagct gcgttcgctt gtccgcacgg
     3721 cggccgcggg ggagaggttg cccagcagcc gggaactcat cgagcgctat cgggtcggcc
     3781 cgggaacggt ctctcgcgct atcgccctgc tggcggcgga aggcatcgtc gtgacccgcc
     3841 ccgggagcgg gacgtacgtg gcgaagaagc cgtcgggggc gggcgagccg ctcgacacgg
     3901 cgtggcagac ggtcgcgctc accgaccgca gtgtcgacac cacatccctc accggcgccc
     3961 tcggtcccgc cccggaggac gcgatccttc tcgacggcgg ctatccgcac cgatccctgc
     4021 aggcgactcg cttcctggcc gcggcgctgg cgcgggcggg ccgccgcccg gacgcctggg
     4081 atcgcgcgcc ggccgccggg ctgaccgcgc tgaggtcggt gttcgcgggg cctgccggtg
     4141 cgtcgccgga cgacgtcctg atcaccgcgg gcgggcagag tgggctgtcc atggcgttcc
     4201 gggcgatcgc ggcgcccgga agcccggtcc tcgtcgaatc gccgacctat ccgggagcgc
     4261 tcgccgccgc ccgggcggca ggcctccgac cggtgccggt tccgctcgac ggcgacgggg
     4321 tccgtcccga tctgctggcc gaggcgttcg cgatgacggg cgccaggctt ttttactgcc
     4381 agcccacatt ccacaacccg accggcacgg tgctcgcggc cgaacggcgc acgcgggtac
     4441 tggacatcgc ccgggcggcg ggcgcgttcg tcctggagga cgacttcgcc cgtcatctct
     4501 cccacggggc gaccacgcca cgtccactga tcaccgacga tcgcgacggc acggtcgtcc
     4561 atctgacgtc ggtgaccaag gccagcgcgc cgagccttcg gatcggcgcg ctgatcgcac
     4621 gcgggccggt cctcgaccgg atgaaggcga tccggcaggt cgacgacttc ttcgtcgccc
     4681 gcccgctgca ggaagcggcc ctcgaactgc tcagcgcgcc gtcctgggaa cgtcacgtcc
     4741 ggaggctcgg tgccgagctg ggggagcggt gcgcgaaagc ggccgcggcg ctggcggcga
     4801 agtgtcctga gtggacaatc gcgcggctcc ccaccggtgg cctgcacctg tgggtgcggc
     4861 taccggcggg gagcgatccg aacgccctcg cccgcgctgc gcgtgagcga ggagtcgtgg
     4921 tcggggcagg ggagcgattc ttcgccaccg agccggcagg acccttcctg cgactgagct
     4981 tcgccgccgc ggccgacatc gccgagctca ccgaaggcat ccggcggctc gacccgagtg
     5041 tataacgacc tatacggcgt gactcaggtc agaaccgctt caagaaacag ataaacacca
     5101 ccaccaatga cgacaccggc gcccgttccg gtcacgacct cggccttgct gtgatcgccg
     5161 agttcgacgc gggaccagca gacccagccc acggcgagga agagcagcgc gagccagggg
     5221 ccgtggacac ggatgagcat cacggccgcc cctgcggcca ccatcgcgtg catcgagatc
     5281 ttgaacttca gcccgaaggt gatcgcgagg gcggcgacca ggcagacgag ctcggcggcc
     5341 gcgagcgcga ccatctcgtg gggcgcacca cccgcgatca ggacggcgaa gccggtggca
     5401 agcgagccga tgcagaccgc gaacgggacg agccgtccgg cgcggtcggt gacgtggtgg
     5461 ctgtcccact tgcctttccg tgcgccgcgc acgatcacgg ccatcgggat caacgagccg
     5521 gtgacgccga cgacgagtcc ccacagcacg gtctcaccga ggtgatggcc ggtgaccttc
     5581 caggcgacga ccagcgggag accgagcacc cagacccagg gggcgagcac ctcggtcgcg
     5641 atccgcgcga cgtgccggcg ggccccgggg gcttccgtgg acagggtggg catggcgggt
     5701 gtctcctcgg ggaaatcgtg gccggagccg ctcctgccgg actggtgccc ggcaggagcg
     5761 gtgatcatcg ttccagaccg cggcgtcccg ctcgcgcgag gatgtcggcg cccgcaggat
     5821 gggctcggct ggcttcgtcg aaactttcct tcggcagcac ggtgttcccg gcaacgatca
     5881 ccgtctccgg cggagtctcg tagccgtcgg gaagggcatc ccagaagttg ccgacgaagg
     5941 cgacgttctc cagcggcgga cccacctgga gcacgatcgg ggtgtcggcc cggcagacga
     6001 tgttgccgag aacggtgatc cacgccgcgc cgtagtcggc gtacagcccg aagttgtacg
     6061 aggtgaggac gtcgcggatg acgttcccgc ggaccatcgc cccacccgcg aacgacgagc
     6121 cctgaggggc cgagagatag atcccgccgc cgtccatcag cttccccatg ctgcgttcga
     6181 cgaggttcga gatcacctgg gtgcccttgg ctcgttcacc gccggtgatc acgatgccgt
     6241 tgtgcgggac gtcgtggatc tcgttgtggg ccacggtggt ttcttcggac tcgacgacca
     6301 ggacggcggg ggagccgcgg tactcggtgc cgatgtggtg gacgaggttg tcctcgaggg
     6361 agacacgggt cgcggagtgg acggcgatcc cgctgcccga gatctcgtcg aagacattcg
     6421 cccggacgtc gatgtcggtg ccctcttcga tcaggagtgc tcccgcgccg agccgggtga
     6481 agtggttgcc ctccacggtg acccggcaag ccgacgtgag actgatgttg gcgggcagct
     6541 ggaccggctc cgccggcaca tggacatagc ccacgtcggc accgaggtcg atcttgtgga
     6601 attcgccccg ctcgtagcgg gtgttgccgt gataatgcag gtagccgccg gtgcgggtgg
     6661 ggccggacca ggccgcgtcg gcgacggtga agccacgcag tacgaggtcg tgcacgccct
     6721 gtccgtcgat gagcgtctcg agcgcagggg cgacgactct ggtcttgccg atctcctcgc
     6781 cggggcgcgg acggtagtgc agcacgtggc cgccccgatc ggtacggctg acggcgaagg
     6841 ttcccgattc ggtcaggaag gcaacgttgt tttcgagcac cgaaggcgcg gcgagaccgt
     6901 cccaggtgcc gtccccgccg gcgccgtacc acttggagtc gtagagggat ttggcgtggt
     6961 cgaacgcggg ctgggccagg gtgatggtgg tcgaagtggc gtcgccggtg atcgacgcga
     7021 ccgctagccg ggcttcggac cacgggtaga cgccggggta gacgaactcc aggcaggacg
     7081 ggtccggcca cgcttgcggc tccgcgctgt ccgtgacgta accggtcgct gttttcgtca
     7141 cgtttcccgg gagaccgtcg gtgcgggccg cgcgggcgac aggccggcct tccacggtga
     7201 gccgccgcgg cgcgaggtcg ccgatgggcg cggtccagac gccgtcgtca ccctccgtcc
     7261 atccggtgat ctcgcggccg ccgctcagtt cgacctctgc ccgccccggt gttccgaagc
     7321 cctccgcctg gtagatcacg cggaagccgt tcgaaccgga atcaccgagc gtgtcgtcga
     7381 agacaagggg ttctgcgagg tggtggacac ctgcgccgaa ggtgacgatg acgtcaccgg
     7441 tcattccggc ggtgacggcg cggacggcct tctgtgccgc tctcggggtg gcgaacggcc
     7501 gatcggcggt gccggcccag tcgtctcgac cctcggtgga cacgaagaac ctgatttcag
     7561 gcatgctgaa gcgctcctac gggaggttta tcggatatac tgaggtttat cagctaaaca
     7621 cggacgagtg acaagcgtca agggagtgcc gggtggtgga agacgacacg cagccggatc
     7681 cggagcgtgc gatcgagctg ctgtggggga catccgagcc ggaccggccg gggttgagcc
     7741 tcggccggat cgtcgcggcg gccgtcgaag tggcggacgc ggaagggctg gcggccctgt
     7801 cgatgcgcaa ggtcgcggaa cggttcggca ccaccaccat gtcgctctac cggtacgtcc
     7861 ccggcaaggc ggaactggtc gaactcatgc gcgacgccgt ctacggcagg tttccgatgg
     7921 agccgtcgga cgggctcggc tggcgggccg gcctcgaacg ctgggcgcgg cgggcatggg
     7981 agatgcatcg ccgtcatccg tggctggtcc acagcggcgg gacccgccgt ctgcccgggc
     8041 cgaacatcat ggccggatac gaccacgcgc tggacgtggc ttcacgaacc ggtctggcgc
     8101 cggcgcaggt gatcgcggtg gtgaacctgg tgggcggatt cgtggattcc gtcgcacgcc
     8161 aggcggggga gaccgcggaa cttcagcggc gtaccggcgt gtcccatgag cgctggtgga
     8221 gtgaacgcga gtcgctcttc gagcggttgg accgttatcc ggccttggaa cgcctgtgga
     8281 agggcggggg gatggacgcg ccgctcgatc agttcgagtt cggactgcag cgcaccctcg
     8341 acggcgtaca ggcgtttatc gaaagccaag agcgtgaggt aatgcgtgac gaaactggcg
     8401 ggggagagtg tgcctcctgc ggcaagccgc tgaacggggg agggcggggc aggcctcggg
     8461 actactgctc gagggcttgc cagcagcgcg cctatcgccg acgtcaagcc gggtcctgat
     8521 tctcgaacga gggtcgtggt ccgccccacg cggggcggac cacgaccggt caggtgagca
     8581 ggtggtcgaa ctcgccgttc ttcgcgccga gaacgaaggc cttgatctcg tgcggttcga
     8641 aaacaaggac ggggctgttc tcgccgagct tcgaatcgcg cacgcccacg taacctttta
     8701 cggagtcgtt gacttcgacg caaccgttcg cgccggcgct gtagctcgat ttccaccagc
     8761 cggaaaggcc gagcagggtg ggacgagaag aatcattgtt cattgagttc ccttgccaag
     8821 ttttgaataa aagaccgtgt ccgcccagga tgctccgctt gtgcctgtag ccgttcgaaa
     8881 gtactgcgaa atcggcggag gtcttcggtg tcctcgtaat agaggccttc gcgtcggttc
     8941 tcgacgtaca cggttccggg atcaccgccg aactcggacg ggtagtccaa aagaatgaac
     9001 ccgccgtccg aggcgccgtg ggcgcctgcg gtgaaggaga gcacttgaat gtcgatgttc
     9061 ggccgttccg acaattcgat caagtgctcc agttgatcac gcatgaccgc cggcccgcct
     9121 acttggcggc gtaggacgct ctcgtccagg atcgaccaga tatgcggtgc atccccaggg
     9181 cggtccaaga tctcttggcg cgccatccgc aagtcgacca tggtttcgag ttcggccttg
     9241 ttgttccagc gtcgaccttc ccgcatgatg gcgagcgcgt aatcacgagt ctggaacaaa
     9301 ccgggcagta cgaccaggtc gacggtgctg atccgagcgg caccggtttc caggcccaga
     9361 tagaggttga accagtcgaa caccccgtgg tcgaagttga tccaccaatc ccgcccgcgt
     9421 ttcgcccgtt tgatcaggtc acggaagaac ggtgcccgct cgggcactcc gtagaaatcg
     9481 agcagaacct ccaggtcggc gggtgccggc agatttcgcg aggtttcgat atgtgcgatg
     9541 accgtcgtgg ccttgccgat gcgctcggcc gcggcggccc ggtcgtagcc cgccgcttcc
     9601 cggaggcgct tcatctcgag cgcgatccag cgcttgatgg cggtgggggt cagcgtgccc
     9661 acgaactgac cacctccctc agagtttcgt cacggaaagt gaccccagta tcacccgtat
     9721 agcgcagagg gtgccagtag accgtggcga atgtatagct ctacatttaa gccctctaca
     9781 tgagggcact ctacattgta gagccgaacc cgccaccggg cgggtcgaaa caacgggaag
     9841 gaggcggacg tgatgggtga ggccgcggtc gtccggctcg ctcccggctg gtcgggggag
     9901 agggggtgtc cggcgatgat cgagatcgtg atggtggagc gtgctgacgc gatccgccac
     9961 gtctacagcg gagacaacgg ttgaccgagg aggggttccg gtgcgtccac gtatcaaaga
    10021 cgagcatcgc ccggtccggt tcggcgacgg ttggatccgg atcggcgggg aggtgttcgg
    10081 catcgccgcc gagttgaggg actcggacgg tgccgtgtgg gcgttactgg aactcctcga
    10141 cggaactcga acagtgagcc aggtcgtcgc cgacctggct cgtctgatcc ccggcacctg
    10201 tccggaagaa gtcaccgacg ccatcgaaaa gctcgccgaa ctcgggtacg tcgagaacgc
    10261 cgacgagccg acttgtatcg cgctgaccga gcggcaactc gaacgccatt cgagaagcag
    10321 gtcgctgtac cggtggatcg atctgacgcg aagaacgtcg agctgggact tccaggtcct
    10381 cctggccagg gcgcgggtcg tgctggtcgg cgtgggtggc gtcgggtgca cggcggcatt
    10441 gagtctggtc atgtccgggg tggggcggct gcactgcgtc gaacctgact tggtggagct
    10501 ttccaatctg gggcgccaga tcctttacac cgaagaacat ctcgggctgc cgaaggtgga
    10561 cgtggcggtg gagaggttgc gtgcggccaa ttcggacgtc gaggtcaccg gggaagcgac
    10621 gcggatcgaa aacgcggctt cgctgcggag gctggccgcc ggctgtgacg tcttgatcat
    10681 gaccgccgat catcccccgg agatccgtac ctggacgaac caggcgtgcg ccgcgaccgg
    10741 cacgccctgg gtatacgggg gttaccacgg cccgcaggtc aacctgggtg tctaccgccc
    10801 gggcgcgggg ccgtgctacg agtgcgcacg gctcgccgag cgcgatcgtg acgcggcgcg
    10861 gccgccgctg gcgacgtggc gtccggccgc gagcatcccg gcgcacgcgg ccaatgcggt
    10921 gacggccggt gtcgcgggca atctggtcgc acacgcggtg atgcgcctga tcaccaacgc
    10981 gccgaagctc gcgctgaact gtcagtacgg cttcagtctc gccacgatgg accacagttt
    11041 cgtcaccagc ttggaacggc cgcacgcgga gtgcgggacg tgtcttgccg ccgggtgatc
    11101 gagtcaggcg tcctcggcca gtcgtcgtga cacgctctgg atcagccggg ccgccgcgtc
    11161 accggacagc gcttcggtat gcagcgtgcc gaacatgtgc tcgtacaagg cgatctcctc
    11221 cggatctctg atcaggtgct cgcctgcgaa caattccacc acgacgagtt cggcgtcgta
    11281 aatgcggaat ccgtgcagcg gggcgatcgg catggccttg ctgaacggaa ggatccgcag
    11341 gtcgacagtg cgcaggccgg ccagtgaccg gagccggtcc agctggccga gttgagtgtc
    11401 gaggtcacct atccggatcc agagggcggc ctcgccgatc accagcggca acgccttgcc
    11461 ggggtcgtgc agttgtgctt gccgttcgat ccgaatggcc accatgcgtt cgatgtcgtc
    11521 ctccgcggcg ccccctgtac gtaccggacc tgaggggagg acgagcagtt cccgcatgaa
    11581 gccgggtgtc tgcaccaggc cgggaagcag tgccggttgg aacgtggcga cacggctcgc
    11641 gcgctgctct agttcgagga cggatcgctg tttggtggcg gctccgcccg gcttgcggaa
    11701 ctcgtcgcgg aacgacaccg attccacgcg ggcacgtttg agcagttcga gaatcgagtc
    11761 cttctggtcg tccgcgcccg ccgcggtgag ccagtcggtg atgtcgtcac cggtcgggaa
    11821 ctggacgccg gtttcgatct tggacactcg tgattggggc cagcccagcc ttttggcgaa
    11881 ctgattgccg gacaggccgg tggccgcccg gagctcgcgg agtttcgtgg cgagccggac
    11941 gcggtcggag ccggggtgag gcggcgacgt gggcatgatc ttctttcgca gggtcgaggc
    12001 gaagcggagc tgctgctcgt tgcgtgatca tgctactccc gcgcagcgct agagcgtgaa
    12061 tagtacacga atagacgcat cagtcatgca taactggcga atagaatcga gcgagacgaa
    12121 gtggccggac aaggggagga ccgatgttcg ccaactggat ccagatcgcc gaactcgcac
    12181 tgctgccact gggcttggga atcggctatg cggcgggacg gacctgtcac cgggaggagc
    12241 gggcgtcctt ccatgaggaa gtcacgatca cccatcccgg cttggtcgcc gaatatcagc
    12301 gcccggtccc ggacgtgggg gccggctgga gatctgcccg gtaggccgaa cccaggggag
    12361 gggacacctc atacggttca agcctccggg tgggggaggg cggcggcagg cctcgaaacc
    12421 cgcgccgggg cctgccgccg acggccttcc caggcaagtg tataacgccc tattcagccg
    12481 ggcatcgaac aagatcattt tatttgttcc caaaaacccg caaagactgt cgggggtcct
    12541 ggctagggtt tcccggtgat caccgaggtc ttgctggaac aggctgaaga agacgttcgg
    12601 acgcctgtgc tcttcaaggg ttttctggaa cccggggcac aggcggccca gtcgctgctc
    12661 gtgctgggga aggtcgcccg cacccggttc tggatgccac cgtccatggt gaaccggctc
    12721 atcgccgagt ccgatccggt gttcaccgcg gacgggacga cgctgcgtgc ggaggccttt
    12781 tctccatgct gcggcgtgta cgccaggctc gacctgccgg acgtgggaga tctcggcgaa
    12841 ggctgtacga acgtcgacct gtccgacgcg acgcggaccg tcctcgcggc ggtcgtcgcc
    12901 caggaccctc tccatctgac cgttcgtggt gagggaatcc gcatccgcac gcttgacggg
    12961 cagaacgacg agtcgcaggt gccgctgccg gatcggtggg tggcgggttt cgccgaagtc
    13021 gcggctgtca cgaagggcgc ggtggagagg gcgaaactcg acaaggcgga gacacggaac
    13081 ttcctgaggc ggatccccac ggttgtcggc aggtcgtggg cggtggtgtc cggtcgcggg
    13141 ctcagaatga cctcgcggcc ggggcgcgac tcgatcccgg cgaccggact gcatcggctg
    13201 cgagtgatcg agccgctgat ccggttcgcc caagggctga ccgtctacac gcgaccggac
    13261 agcgaggtct cgacctgggt tctgcgactg gaacgcgcgc gcttcgccgt cacgctgtcc
    13321 ccggagccgt cccgtggctt ttcgggggaa ggcggctggc tgaactcgct ggccgccggt
    13381 ctcgaagcgc cggagctggt ccatggtcgc gccggtcacg acgtcgtcga cggcacgtgg
    13441 ttcccgcgcg aactcccgag cgggaacgct ccggcgaacg gccgtctggc caaggcccgc
    13501 gagctcgtcg ccgccggagc cgtccgcttg ttgcccgacg gtggctacga gatcacgcgt
    13561 ggcgcttctg tacagcgcgt ccggctttcc ccggccgggt gcacgtgtgc gtggtgggcc
    13621 aagcaccagg agacccgggg cccgtgttcg cacgtcctgg cagcgcggat gtcatcggcg
    13681 gagtcgtgac gccgccttcg ccgctttcga actgcctttg aaacccgtca gccactcctt
    13741 cgtttcggcg ctgatcgtgc cggctccgcg ttcgacgagg tccgcggcga gttccaagag
    13801 cgcgaagacg ccgcgatggg agtgctccag cttcggcagc aaagtgtcca gtgtggacag
    13861 agcggccacg ggatgttcgt tcgcgatgat cgacaaccgg ggagccagcc gggtcgcgat
    13921 gagggtgggg ccgagcactc cgaacgcctc gccgagtgcc cgggggccga gcaaccggcg
    13981 gtcgagaagg gtcagcacgg cgtccgtccc cagctggacg gcggtggggc gtttcagcgc
    14041 gagggtgatc gcaaggagcg tcgtaccggg gaagcccggg atcgatgggc tgtccaggaa
    14101 cgggggcagt gcggtcttct ccacgggata gccgaattcg gtgtcgttgg agaacagggt
    14161 ttcggcgacg gcggcttcca gatggtcccg gtcgtagggc gaggcgaccg cttcgtggca
    14221 ttcggtgaag ccgagccact cgggggccga gccgtcgaaa ggcataccca gccagggagc
    14281 tttcggagac accgctgccg gggccgactc gatgtccagt gagatgaggc cgtagtcgtt
    14341 ggggccggtt gtcgccgtcc aggtgagcgg cggtccgggt tcgccgcgga gcgcggcggc
    14401 ggggtcggcg gactccgggt gccgggcgcg ggcggcggcg agtgcgaccc agcctgtttc
    14461 ttcgagggcc ggtccgccga gggcatagcg gatgctgtcg gcatacggcc cggtgagttc
    14521 agaggcgagc gtaagagctt ctggcctggt gtccggagcg agccggagga ggccgtcgac
    14581 gacgtcgtct tcggccgcgt cggggtgatc gagcatgcgg gagacgaaga cgacgggatc
    14641 gagccagccg cctcggtggg tggcggcgga gacgggcgtg gcggtgcctt cgagcagggc
    14701 ggcgacccgg tggtggagcg gacgtctcca gccgtcgacc ttgcgtggga gcgtcacgtc
    14761 gcggccggtg aggccgagga cgagggtggc gatcatcttc ggcacggccg cgctgtatct
    14821 ctggtcggtg atcctggtgg cgcgtttcac cagtggtttg agggcgtcct ggagttcgcc
    14881 cgcgacacgg tgggcgccgt cgagagcggc caggaggagg tcggcctggt cgggatcggc
    14941 cagcagggag gagagggctt ccgcgaccgc ggccggggtg tcggggattt cgagcgggat
    15001 ggtcaaggtt ttgcgctggt cccacggtgg ccgcgtgggt tcggggtatt cggcggcctc
    15061 gatggcgggt gcttcgtcgg gggtgacgcc gagccgggcg atggcgacgg cgcggacgcc
    15121 ggaggcctcg tgggtgagtg ccgcttcgaa gacttcgtcg gcgagatcgc tgagttcggg
    15181 ccgccggtcg gcgatgcggc cggcgagttt gagcgcgagt ccggcggtgg ccgcgccgcg
    15241 tccgcccgct gccgcgggga ggtgctggag tgcgacttcg tcgtcgagcg tgccttgttt
    15301 gtccacaagg gacagcgctt tgacggcgaa ggagacggtg cgcgggaggc cgcttccgca
    15361 caggcgggcg tagcggtgtt gtgccttcgt gcgctcgtcc ggggtggggg cgagtgcttc
    15421 gtggagcgcg gcgtaccact gggcacggaa ggcggcgaag tcgcgggcga ggatgtcgag
    15481 ggtgaggtcg agcagtctgg ctcggtcgat ttcaccggtc tcggtgagtt cgagcagcgc
    15541 ggtcgaccac ttgtcctcgt cgcggacgta cttgtcgaag gcggcgaagc tggcgtctcc
    15601 gttgccttcg gtcgcgagca gttcccagag ttcggtgagg gcttccggtt cggtccggag
    15661 tcgctgggcc aggggttcgc cgcggaatcg tccggcccag cggaaccagc cggcgtggta
    15721 ctccggtgtc cggatgggtt cgaggtcgcc gtcgaggatc atgcggcgga tggcttccca
    15781 tgcggtctgg tggccgatca tgcgcagggc gatcgtcttg cgttcggcga gtggccggtc
    15841 ttgcaggacg cgttcgagga tcgtgggtga ggcgatccag agtttgcgga gcagggggtc
    15901 gcttgcgggg agggcggccc agagcgcggt ggcggcttgc tggcctctga gcgggttgcg
    15961 ggcgccgtag gtgttgggct cgatctcgat gaactcgctg ctgtccttga acgcggccag
    16021 gagttcgggg atgagggctt tccgctcggc gcgggagagc tcgagggtcc gggtgaggac
    16081 ttccgagggc tggccggtga ggagcgcgtt cagctgcacg aggtcaactt agcggcctgc
    16141 cggtctcgtg cgtggtaagt gccgtttttc cggttcctgg agtccgtgaa ggcctccttg
    16201 agagactctg ggtccctcaa ggaggccttc acggactgga cagaggacgg gggacgcggc
    16261 cgccgtcgtg aggtggtgca ggctcagatg aggccgagct tcttcaccgc gtcgcgctct
    16321 tcggccagct cgttgaccga agcgtcgatg cgggcgcgcg agaagtcgtc gatctccagg
    16381 ccctggacga tcttgtactc gccgttcgcg gcggtgaccg ggaacgagga gatcaggccc
    16441 tccgggacac cgtaggaacc gtcggatacg accgccgccg aagtccagtc accctcgggg
    16501 gtgccgttga cccaggtgta cacgtggtcg atcgcggcgg aggccgccga cgccgcggag
    16561 gacaggccgc gggcctcgat gatcgccgcg ccgcgcttgg cgacggtggg gatgaagtcg
    16621 tcggccagcc actgctggtc ggtgatgacc tcggtcgcgg gcttgccgga cacctcggcg
    16681 tgcgcgatcg acgggtactg ggtcgcggag tggttgcccc agatcgcgac cttcttcagc
    16741 tcggtcaccg gcacgcccag cttcttcgac agctgcgcga gggcgcggtt gtggtcgagg
    16801 cgggtcatcg cggtgaagcg gtcggccggg acgtcgggcg cgtgcgcctg cgcgatgagg
    16861 gcgttggtgt tggccgggtt gccgaccacg aggaccttga tgtcgctcgc cgcgccggcg
    16921 ttgatggcct caccctgcgg cttgaagatg ccaccgttgg cctcgagcag gtcgccgcgc
    16981 tccatgccct tggcgcgggg acgggcgccg acgagcaggg cgacgttcgc gccctcgaag
    17041 gcctgcttcg ggtcgtcgaa gatgtcgatg cccgacagca gcgggaacgc gccgtcttcg
    17101 agttccatcg cggtgccctc agccgccttg accgcctgcg ggatctccag gagccgcagc
    17161 ttcaccgggg tgtccgggcc gagcagctga ccggacgcga tgcggaagag cagcgcgtag
    17221 ccgatctggc cggccgcacc ggtgacggtg acgttgacag gggcttgggt cattgcggtt
    17281 ctccagcttg aggcgacatc gacttgtacc gcgatgctag tcctgtcccg agtcgccgtt
    17341 cgggtgcgtc cagtcactgt tttcttgatc gatgcggtcc gcggccgcgt cacgccgccg
    17401 ggtgacccgg ctcacgcgat ccggcgcatc ggtacgccgg gggcgagcgg cggaaacggc
    17461 ctgtctctcc gaaatcgtca acggcgaacc cgcgaaagcc ttttccatat cgtgcgaagt
    17521 gaatggtgtt ttccgggggc aacggtgttc ctcttggatc cggaaaacgg ttacagacca
    17581 taaccgcatt tcatgaaccg attgccggga ggtttgcgtc cgatcggcgg gcggcatcgt
    17641 gaagatcgtt tcgctaacat gagtccgccc agttccccgc cccccgtgtg aaagttttcg
    17701 ggaaggaccc catgctcagc gcaatggttg ccgccgtatc gcttttctcg tcgataataa
    17761 caccgaacag catgtccccg ccgccgggac cgccgcccga ccgcgtcgtc atcgacgtcg
    17821 tgaccgtcaa cggttccgga tgtcctccgg ggtcttccgc ggtcgccgtc gccaaggaca
    17881 acaccgcgtt caccgtcacc tacagcgaat acaccgctca ggtcggcgtc ggcgcgaaac
    17941 ccaccgactt caggaagaac tgccagctga acctcaacat ccacgttccg caggggttca
    18001 cctacggcat cgccagtgcg gattaccgcg gtttcgccca tctcgaatcc ggcgcgaagg
    18061 cgctccagcg ggcgaattac tacttccagg ggaattcgcc gaccgcgcat gtcagtcatc
    18121 ccgtcaacgg gccggtttcg gacaactggc aattccgtga cgaggccgag ggtggcgtca
    18181 tcatctacaa gccctgcggc gaggatcgga acctcaacgt gaacacggaa ctgagggtcg
    18241 gcgccggttc gtcggatccg aagaagacca ccagtttcat cacgatggac tcgaccgacg
    18301 gcgcgttcaa gaccacctac cacttctcgt ggaagacctg tccgacctcc tgacctctgt
    18361 tcccgggtga cggcctgctt cctggtccgg aagaaggccg tcccacccat gccccggtca
    18421 gggtcttggc tgccctgaac gaggggtttc accgctcgcc gccgcccgtc cggcggcggc
    18481 gagccgtctc gacgacctca ttttcggcgg tcaccctcgc tcggtgaccg aaaccgtttc
    18541 cgcccgatcg gcggccgacc cggagaagaa cgtctcgctg acctcgaatc cgcccggatc
    18601 cgccgtgtgg aagctttggg aaggatccca tgctcaacgc gctggttgct gccgtaacgc
    18661 ttttctcttc gaccatcacc ccgaacgcct gggtgccgcc cccgctgccg tccgacaaaa
    18721 tagtcatcga cgtcgtgacc gtcaacggaa ccggatgcag acccggtacc gcggctgttt
    18781 ccgtttcacc ggacaacacc gcgttcaccg tcacctacag cgaatacacc gcccaggtcg
    18841 gcgtcggcgc gaaacccacc gatctgcgca agaattgcca gctcaacctg tacgtccacg
    18901 tgccgcaggg attcacctac ggcatcgcgg gcaccgatta ccgcggcttc gcctctttgg
    18961 ccgcgggcgc caccggactg gaacgggcca actactactt ccagggcaat tccccgacgt
    19021 cctatgtgaa tcacagcctc aaaggcccgt tcgaggacaa ctggcagttc accgacaaca
    19081 tcgaagtcgg cgccatcgtc tacaagccct gcggtgagga ccggaacttc aacatcaaca
    19141 cggagctgcg ggccggggtc ggcacttccg atccgaagaa gaccaccagt ttcgtcacga
    19201 tggattcgac cgacggttcc atcaagacca cgtaccactt ctcgtggaag aattgcccca
    19261 aaccgaagag ctgacccctg acggctcgtg agtggtaagg acggttctaa ccgtccttac
    19321 cactcacgac ttgccggagg gctccgggtc ggtggcctcg accccgaaca cgcggcccag
    19381 cgcgatgacc gtctcgtcga ggtgcccaag gctggtgagc accgaacgcg cccgcggatc
    19441 gtcgatccgg tccgccaccg gcgtgccgtc gtcccggatc agcgtcccgt gccccgatgc
    19501 gccggggtcc ccgatcgcct tcctcagtat cgcggtgttc tcccggatcc gtccggtgta
    19561 cagcagcagc cggtccgcct cgttgagcag gagaccgggc tgggaccggg ccgcgacgtg
    19621 gcgggcgcgg aaggcgatcg tctccacggt cgtgagcacg tgccagccgt agtcacgacg
    19681 gctgctgaga ttgaccggat gggtgagcgg ctcgatcgtc gtgcggacct tgtccacggc
    19741 ccggtccagg tcacgggact tctcgatgac gctcacgttc tccgcgccgg acagcagcac
    19801 cgccgccttc tcgacgaact cgtccagttc ctccagcagt gccgagacgt cgtcgagcat
    19861 caccgcccgg gttcgcaccg gcacgatcac caccgccgcc agcaccccgg ccgccgcgcc
    19921 gacggcggtc tccgcgaccc ggatccacag cacctcgatg ctgaacgtcc ccagcaggct
    19981 gtacagcagc ccgagcatgc tggtgatgaa gaacgccatg atcacctgcg acacccgcgc
    20041 catgtagacc atgccgaaca cgcacaccag gatcagcgcc agcgtcgccg gcacgctgcc
    20101 cgacaccagc agcgtcagca ccagcccgcc cacgatcccg atcagcgtgc cgccgagccg
    20161 ccggacaccc ttgacgaacg tcgcccccgc ggtcgacgag ccgatgaaca ccacgaacac
    20221 ggtcagcacg gcccagtacc accgctggct cgacaccagc tccccgccga gcacggccag
    20281 cccgccgccc accacggcct ggatggcgct gcgcgtctgg ttgtcgtagg cgaacgccga
    20341 cgacttctcc tcctcggggt cttcgggatc gtcggcggca tcggagacgt cgtgctcggc
    20401 cactcgctgt gcgcgcacgt cggccagtgc gagttcggcg agcgcgcggc ggacgccgtc
    20461 accgggcgcg gcgtgctcgt cgatccggct gccttccacc agcatcttgc tgaactcttc
    20521 ggtctcgctg atcagcggca gctctcgcgg gtcgcgttcg atcagcgacc ggaagcgccg
    20581 catccgcgcg atcagatcgt cgcggacgtc gtcgtcgagg tcttcggcac aggtgcgctg
    20641 cactgtgatc gtcagccact gcaccgccag ctcgacctcg atcgcccggc ggcggagccg
    20701 gttcaccgaa tccgctccgg tcacctccgg tgcggtgtcc tcgatgagca ggacggactc
    20761 gtgcatccgg gcgttcgtcc tgcggagccg tttgcgagtg cgctcgctgc cgcccaccgc
    20821 gaggtggtcc tcggccgcgc gtaccaccgc ggcgagccgg gcccggaacg cccgccggat
    20881 cctgaggaac tccgcgtcgg tgtgcctgcg cagcaggacg aaccggacca ccgcgttggc
    20941 cgcgatcccg atggtcagcg ccagcagcag cgccgggacc tgtttcaaat gcgtctgcag
    21001 gaacatcgcg aagaagaaca ggaagaacga cagcgagccc agggcgatgc cgcgcgagcc
    21061 gaaccgctgg gcgtagaccg cgacgaagat cagcagga
//
