LOCUS       NZ_CP024972            22880 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1672842
            Orig. end                         :: 1695722
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22880
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="8"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22880
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22880
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12880](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12880)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(953..968)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.38"
                     /tool="antismash"
     misc_feature    1260..1274
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.28"
                     /tool="antismash"
     gene            complement(1887..2567)
                     /locus_tag="CVV72_RS07530"
                     /old_locus_tag="CVV72_07495"
     CDS             complement(1887..2567)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334472.1"
                     /locus_tag="CVV72_RS07530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07495"
                     /product="hypothetical protein"
                     /protein_id="WP_219151684.1"
                     /transl_table=11
                     /translation="MAEEKAPQAGPVGKLFHAGFHALAALRGARAFHPNGLLFNGELQA
                     LRRDDLALPEEPVAVTVRMSKGAGLPGRVPDALGMAVRIPAVGGHPWDLTLTTSGTGLA
                     GRVLPRPERAWTSGRYSTLLPYRTKGGLVWLAARAEAARNVEASLDGLRRLVAEGPVTY
                     LVETVRANGHRKPCATLTLHEVDDDSPQPAFDPMLNLPPGWELRPRWLTGLRERAYEGS
                     RKGR"
     gene            2754..3209
                     /locus_tag="CVV72_RS07535"
                     /old_locus_tag="CVV72_07500"
     CDS             2754..3209
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013225123.1"
                     /locus_tag="CVV72_RS07535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07500"
                     /product="DUF4383 domain-containing protein"
                     /protein_id="WP_219151685.1"
                     /transl_table=11
                     /translation="MTASPATVRRAPRQLIALGVGAVFLLVGILGFIPGITTNYEQLSG
                     AGHESGALLLGVFQVSILHNIVHLAFGVAGILLARTVTGAKAFLVGGGVIYLVLWLYGL
                     LIDHGSAANFVPVNTADNWLHLGLAVGMIALGLIPFSGSKAPIADSR"
     misc_feature    complement(2797..2812)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.68"
                     /tool="antismash"
     gene            3244..4125
                     /locus_tag="CVV72_RS07540"
                     /old_locus_tag="CVV72_07505"
     CDS             3244..4125
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334470.1"
                     /locus_tag="CVV72_RS07540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07505"
                     /product="manganese catalase family protein"
                     /protein_id="WP_219151686.1"
                     /transl_table=11
                     /translation="MFRHTKSLQFEAKPEKPDALYARKLQELIGGAYGEMTVTMQYLFQ
                     GWNCRIEGKYKDLIMDTATEEIGHVEMLATMVARLLEGAPATTVAEAAKDPATAAILGG
                     MDPQQAIISGGGATPSDSQGYPWNGRYVVASGNLLADFRANVAAEAQGRLQTARLYNMT
                     DDPGVKAMLQFNLARDTVHQKQWLAAIEELKADGLESDIAPTALFDEENQDHNNTVWHL
                     SDGPDGPKGGWSFGEDGIEYLMEPEALGGPGTAPKPDPALYGTYAPLQDAVGTVKGKVK
                     DAKKKATKSSKS"
     CDS             complement(4376..4537)
                     /gene="allorf_1677218_1677379"
                     /locus_tag="allorf_1677218_1677379"
                     /protein_id="allorf_1677218_1677379"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTTVYVKRVELIPSTRLTDRGGARSWRFLAAGPHEQAAFPLAPVR
                     CVLLRFLS"
     CDS_motif       complement(4469..4537)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTTVYVKRVELIPSTRLTDRGGA"
                     /locus_tag="allorf_1677218_1677379_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(4376..4468)
                     /prepeptide="core"
                     /locus_tag="allorf_1677218_1677379_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.70"
                     /molecular_weight="3374.0"
                     /monoisotopic_mass="3371.9"
                     /core_sequence="RSWRFLAAGPHEQAAFPLAPVRCVLLRFLS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTTVYVKRVELIPSTRLTDRGGA"
                     /leader_location="[4468:4537](-)"
                     /alternative_weights="3392.0"
     gene            4557..5099
                     /locus_tag="CVV72_RS07545"
                     /old_locus_tag="CVV72_07510"
     CDS             4557..5099
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS07545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_07510"
                     /product="hypothetical protein"
                     /protein_id="WP_219151687.1"
                     /transl_table=11
                     /translation="MEEFPDPSGPPYPYKYPLPAEAKAEHQRAVEYFRRKYAFWDSMMM
                     PSISVGLVAAGVLSEDDEGYLSVPVLLGVLVVTGVLMALIGLRKDALADKRDKHVNLLK
                     TYRVLPHEIDGSASATLPSDFDTNRDHFGAPLPGKADPCPRAMPDSTPAIDKIPGENPY
                     NGMIRLSPPKPRPESGP"
     gene            complement(5326..6300)
                     /locus_tag="CVV72_RS07550"
                     /old_locus_tag="CVV72_07515"
     CDS             complement(5326..6300)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226134.1"
                     /locus_tag="CVV72_RS07550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07515"
                     /product="YihY/virulence factor BrkB family protein"
                     /protein_id="WP_255632571.1"
                     /transl_table=11
                     /translation="MAAIAKDPDGPTELSRRSWWAVLKRTFVQFNRDNMLDWAAALTYY
                     GVLSLFPGLLVLTAILGLLGPSATQALVENVSRIAPGQGRDILVGAIEELSKTGGLAGT
                     AAILGTAGALWSASGYIGAFMRASNVIYSMPEGRPIWKTVPLRIGLTIAVLVVLALCAA
                     GVVATGGIARYLGDLIGLGSTGVLVWDIAKWPVIALLAGLAVAMLYWVSPNVRQPKFRW
                     LTPGGLVAVLLWAAATAGFAFYVGNFGSYNKVYGSLAGVIVFLIWMWISNIAVLLGAEL
                     DAELARGKEIASGSPADDEPFLPPRDTKAMDDDEAAAVAEADD"
     gene            complement(6360..6572)
                     /locus_tag="CVV72_RS07555"
                     /old_locus_tag="CVV72_07520"
     CDS             complement(6360..6572)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029577.1"
                     /locus_tag="CVV72_RS07555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07520"
                     /product="ferrous iron transport protein A"
                     /protein_id="WP_219151688.1"
                     /transl_table=11
                     /translation="MTLPEVPLGTRVVVRYRIEGGFTDALGYLRSRDDTDCTVETKRGL
                     ATIRLADIVLAKTVPPPPPPRSRPA"
     gene            complement(6569..6808)
                     /locus_tag="CVV72_RS07560"
                     /old_locus_tag="CVV72_07525"
     CDS             complement(6569..6808)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334468.1"
                     /locus_tag="CVV72_RS07560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07525"
                     /product="glutaredoxin domain-containing protein"
                     /protein_id="WP_125677434.1"
                     /transl_table=11
                     /translation="MSDLTVYGAGWCPDVKRSRALLDSKGIEYDYIDVEADSGAEETVR
                     ALQNGERRIPTIVWPDGTHLVEPSDDELTAHLNR"
     CDS_motif       complement(6782..6808)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSDLTVYGA"
                     /locus_tag="CVV72_RS07560_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(6569..6781)
                     /prepeptide="core"
                     /locus_tag="CVV72_RS07560_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.90"
                     /molecular_weight="7733.4"
                     /monoisotopic_mass="7728.9"
                     /core_sequence="GWCPDVKRSRALLDSKGIEYDYIDVEADSGAEETVRALQNGER
                     RIPTIVWPDGTHLVEPSDDELTAHLNR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSDLTVYGA"
                     /leader_location="[6781:6808](-)"
                     /alternative_weights="7751.4"
                     /alternative_weights="7769.4"
                     /alternative_weights="7787.5"
                     /alternative_weights="7805.5"
                     /alternative_weights="7823.5"
                     /alternative_weights="7841.5"
                     /alternative_weights="7859.5"
     gene            complement(6812..9700)
                     /locus_tag="CVV72_RS07565"
                     /old_locus_tag="CVV72_07530"
     CDS             complement(6812..9700)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029579.1"
                     /locus_tag="CVV72_RS07565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07530"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_219151689.1"
                     /transl_table=11
                     /translation="MGIRSSRVIGRDAELAELSEALDRAVAGRGGAIFLVGEGGIGKSR
                     LAVEAASRAVAADIPVLQGRASSIGPLVPFRPLAQALWSHFRGGGPPAAAELDPFIPVL
                     AQLIPDWGRGDRPRDSGSLMVLAEAVFRLLAVTGRDRGALLVLDDLQDADAETLFILEY
                     LVDNLSAAQALFVGTLRNEPSDALRLATSGAQRMSCAVVELSRLGLSDTRALAAACLET
                     EPGRLPSAAAELLWRNSAGLPFIVEELLHGMVNDGLLVEGRDGWRVIGELRARVPAALV
                     TSIGVRMEQLGEQAGELLSVAAIIGRRFPLTVVQAVTGTNDRTLHNHLSAAVSANLVTT
                     DETTPGWYAFRHPLTAEALLARQSPARKATLARQAADAVEKLYPGLPGDLCALVASLRL
                     TALDEQAAGHLFAETGRRALDAGAADSAVTMLTKAVDLLGGADAGDRAEVLETLVLALG
                     QTGQFDRAVELSAAFGEIGTLERAAKLHTQLAWAAYIAGRHDECLGQIERARAPLGSAI
                     SPAQQAALDAVEANLWLDVPGRAGTAERLARQAWEVAEATEQPFVVCQALQVLGMLALS
                     RDLTESEHYMQLARRTAEDNHLHHLRTQALVRLGGHRVLMNGDEQTLLLARADAQRTGS
                     ITLHCAVDSVRTMHAILRCEFGTAHALLAENLAVLGRLRLTALLQYAHMTRAMSAGHRA
                     DRPAMEQALDDFRDSGGENAQEMVLSIGLARVFCSLLEEDFDRARRELGQVVELEDRRP
                     SRFHLAGQHGLRTLVDTLGGVPCPEDGSAVSGMRWNRQFVEFAHAVEHGRRGDAAAAAQ
                     AVASALETSAPYPLARHLGLRLIAEPAAADGWGDPAGWLKEAEEYFHRRDIPAVAAACR
                     SLLRKLGAPVRQRRSGVDRVPGDLRASGVTVREYEVLVLLAERMGNKDIGARLHISPRT
                     VEKHVASLLAKTGLADRAALAEHAGGPRPGML"
     gene            complement(9793..9987)
                     /locus_tag="CVV72_RS07570"
                     /old_locus_tag="CVV72_07535"
     CDS             complement(9793..9987)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029580.1"
                     /locus_tag="CVV72_RS07570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07535"
                     /product="hypothetical protein"
                     /protein_id="WP_034318598.1"
                     /transl_table=11
                     /translation="MYERDLPATEDVLGAVNLPRALEVGSRNHALAGGKPRLSANPLAT
                     LSTDPGSPSVVSVFTGGWI"
     gene            complement(10001..12880)
                     /locus_tag="CVV72_RS07575"
                     /old_locus_tag="CVV72_07540"
     CDS             complement(10001..12880)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635680.1"
                     /locus_tag="CVV72_RS07575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07540"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_255632572.1"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-96, bitscore:
                     323.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 4.1e-15, bitscore:
                     54.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVTPPASATSLPPRWWVHGQTPRERTADKPAWADFAERTITAL
                     LPERPPVGDWRVEFAGVFRSFVHAASREAVPDDLPRADAEALRRGFAAQLDRHLLTLAV
                     RTLVLELHRDRKAGNLRGETPEERFSDFVRRLATPAGLVRLFGEYPVLARLVAQACLHA
                     AEANAETLARFSADAALLPCSVVDGELGTLVEVAGGIGDSHARGRSVKLLRFSSGAKVI
                     YKPRPLILHERFTDVVEHLNKRLPGLELRTADALPREGYGWLRFVEHRPCADIGDVDRF
                     YRRQGILLALLYALDATDVHYENIIACGDQPVLIDIETLFQPSPPDPPEGDPAAAMLAR
                     SVQRTLLLPQLFAGEHGAVDISGLAGRGGKLPTDRIEWADPGTDRMRLVRVPGELAGGN
                     NLPRLDGRDIPPTEHSAALLAGFRLGYDAISTGRDELAEHLRRCAEDPIRVLIRPTNFY
                     FRLLDETTHPDLLRDAADRDRAFDLLEQDSADEEKLLRLVPHERDDLWAGDVPMFTSHP
                     GSTSLLDSRGESVDGVVDRPSLATVQAKLADMDPLDQRDQEWLISATLAISTVTAGHHG
                     GSETAETAAPNQAPDPERLLVTACGIADQIVANAFSDEHRSNWLGIELVDDRYWTVLPM
                     GAGLGEGYCGVALFLAQLAELTGIARYRDLAAYAISPLPGLFTTLRADRELAATAGCGG
                     LLGLGGVAYTIARLSTLVGLPAGDLIEQAVDLMPDATPETPSGFTTGLAGGVASMRSVY
                     VQTGLDSALARADRYAGELLGRERPRERSFARGSAGIDWVLRAHDRSGEEPPGKADDRA
                     ESTVGWCDGLAGDALGLAAHLPDPAYARDLARTIKRLADGAPLKDLSLCHGESGVLEVL
                     CVLAENGHTGAAAAVRRRTGHLLAAIDQRGARCGTPGAVPSPGLLSGLAGIGYGLLRLG
                     FGDRVPSALLLRPDRPHPAATVVPPVNRV"
     misc_feature    complement(12341..12343)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    12980..12994
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.63"
                     /tool="antismash"
     CDS             complement(13294..13407)
                     /gene="allorf_1686136_1686249"
                     /locus_tag="allorf_1686136_1686249"
                     /protein_id="allorf_1686136_1686249"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVQIFDRSSREHNRTRNPIQGAPQCRCSPSTCTTATT"
     CDS_motif       complement(13342..13407)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVQIFDRSSREHNRTRNPIQGA"
                     /locus_tag="allorf_1686136_1686249_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13294..13341)
                     /prepeptide="core"
                     /locus_tag="allorf_1686136_1686249_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.40"
                     /molecular_weight="1430.6"
                     /monoisotopic_mass="1429.6"
                     /core_sequence="PQCRCSPSTCTTATT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVQIFDRSSREHNRTRNPIQGA"
                     /leader_location="[13341:13407](-)"
                     /alternative_weights="1448.6"
                     /alternative_weights="1466.6"
                     /alternative_weights="1484.7"
                     /alternative_weights="1502.7"
     misc_feature    complement(13420..13429)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 17.13"
                     /tool="antismash"
     misc_feature    complement(13422..13436)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.62"
                     /tool="antismash"
     misc_feature    complement(13423..13434)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.36"
                     /tool="antismash"
     CDS             complement(13463..13615)
                     /gene="allorf_1686305_1686457"
                     /locus_tag="allorf_1686305_1686457"
                     /protein_id="allorf_1686305_1686457"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MWITDSCHAPPACRSGGLDSTSANLELATHSVIAREARPGAKHER
                     LTCLS"
     CDS_motif       complement(13493..13615)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MWITDSCHAPPACRSGGLDSTSANLELATHSVIAREARPGA"
                     /locus_tag="allorf_1686305_1686457_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13463..13492)
                     /prepeptide="core"
                     /locus_tag="allorf_1686305_1686457_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.00"
                     /molecular_weight="1050.2"
                     /monoisotopic_mass="1049.6"
                     /core_sequence="KHERLTCLS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MWITDSCHAPPACRSGGLDSTSANLELATHSVIAREARPGA
                     "
                     /leader_location="[13492:13615](-)"
                     /alternative_weights="1068.2"
     CDS             complement(13561..13731)
                     /gene="allorf_1686403_1686573"
                     /locus_tag="allorf_1686403_1686573"
                     /protein_id="allorf_1686403_1686573"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRERSPSRNRPERSVFLRAIGRGVASPVSVILADLPFVACGSPIR
                     VTRPPLAVAEA"
     CDS_motif       complement(13618..13731)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRERSPSRNRPERSVFLRAIGRGVASPVSVILADLPFV"
                     /locus_tag="allorf_1686403_1686573_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13561..13617)
                     /prepeptide="core"
                     /locus_tag="allorf_1686403_1686573_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.90"
                     /molecular_weight="1772.1"
                     /monoisotopic_mass="1771.0"
                     /core_sequence="ACGSPIRVTRPPLAVAEA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRERSPSRNRPERSVFLRAIGRGVASPVSVILADLPFV"
                     /leader_location="[13617:13731](-)"
                     /alternative_weights="1790.1"
     gene            13754..14236
                     /locus_tag="CVV72_RS07580"
                     /old_locus_tag="CVV72_07545"
     CDS             13754..14236
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS07580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_07545"
                     /product="hypothetical protein"
                     /protein_id="WP_034318595.1"
                     /transl_table=11
                     /translation="MFRRTIATVSVALATAFGLTVAADSAAAGTVTQTFACHPRLASQT
                     VHVTVTAPATVKKNVEAAVSVKVENVQPYPGPGSGRPYTSGRLVLGGAGSGTVNFYLSS
                     PTVLEPGDPWIMQGTAKVTFTSTGTGTLASNGYGVPPYYNCGQADPPVAETVTVQP"
     misc_feature    complement(13757..13770)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.33"
                     /tool="antismash"
     gene            14253..14747
                     /locus_tag="CVV72_RS07585"
                     /old_locus_tag="CVV72_07550"
     CDS             14253..14747
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS07585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_07550"
                     /product="hypothetical protein"
                     /protein_id="WP_219151691.1"
                     /transl_table=11
                     /translation="MFRRKIAAVAIAVATGFGLSVTAGTASAGTVTQTCRPYSGPRTVN
                     VTITAPATATSGVPVPVFVKVDGVEPWPNSELSAGSARLVGFLRQGGAGTGEVKIDVLN
                     NPATIPTGGHFSVEGTQQVTFSTPGTVTLGLHRFGKPLTYWWCALPADEQPPVAATVTV
                     N"
     gene            complement(14816..15043)
                     /locus_tag="CVV72_RS07590"
                     /old_locus_tag="CVV72_07555"
     CDS             complement(14816..15043)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CVV72_RS07590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CVV72_07555"
                     /product="hypothetical protein"
                     /protein_id="WP_219151692.1"
                     /transl_table=11
                     /translation="MKKIAATAAVLGAMASTIAFAQPAGAGVDPRYYYESSWSTEGDCR
                     LNGHSGQQSGRWSAYFCSASTWSWDLYIKR"
     CDS_motif       complement(14981..15043)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKIAATAAVLGAMASTIAFA"
                     /locus_tag="CVV72_RS07590_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14816..14980)
                     /prepeptide="core"
                     /locus_tag="CVV72_RS07590_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.90"
                     /molecular_weight="5971.4"
                     /monoisotopic_mass="5967.8"
                     /core_sequence="QPAGAGVDPRYYYESSWSTEGDCRLNGHSGQQSGRWSAYFCSA
                     STWSWDLYIKR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKIAATAAVLGAMASTIAFA"
                     /leader_location="[14980:15043](-)"
                     /alternative_weights="5989.4"
                     /alternative_weights="6007.4"
                     /alternative_weights="6025.4"
                     /alternative_weights="6043.4"
                     /alternative_weights="6061.5"
                     /alternative_weights="6079.5"
                     /alternative_weights="6097.5"
                     /alternative_weights="6115.5"
                     /alternative_weights="6133.5"
     gene            15273..17381
                     /locus_tag="CVV72_RS07595"
                     /old_locus_tag="CVV72_07560"
     CDS             15273..17381
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005159099.1"
                     /locus_tag="CVV72_RS07595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07560"
                     /product="acyltransferase family protein"
                     /protein_id="WP_219151693.1"
                     /transl_table=11
                     /translation="MTLAQVEQAVPRGAAPAGPRGQRRDIQGLRALAVGLVIVYHLRPE
                     WLPGGFVGVDVFFVISGYLIIGTLAGELRRTGTIRLREFYARRIRRLLPAASVVLLSTV
                     FVTWLILPISRWPAVMSDVLTSALNVQNWALAAQSADYAHATAAASPVQHFWSLSVEEQ
                     FYLFIPLVLLVCARLAHRAGPKAARQAVIAVALVTAASFVFSVVYSELDHGRAYFVTPT
                     RMWELGLGGLAAMTVHRVRLKSGVRLLFGWGGMVAVLLGSFLLTTAMAFPGYLALLPTL
                     GTIGLLLAGTVAADQRVARPEVSVVLGLPPLRYLGDISYSLYLWHWPVIVVVLQLAGST
                     ELTRRQAVGVFVLSLALAMVSKHLVEDAFRGGRTTPFRRRTPRLRSAYLLGAALVAVTA
                     VAATVPWQYASAELERLASAARLDEGHPGALALDKDNPRATPDGVPLTPDPAVATQDWP
                     LRDLSVNCTVYDIENWPPTGDKCIYGAATAPKTIVLVGDSHAAMFSTVFARFVREHPEW
                     RVKMMLRNGCPFTAVAPAGLTVCSDQNELELAGILAMKPELVVTSAMSPESYDKDLKWR
                     WESRAQTVDGYETMLRRISDAGIRTGVIRDVPRPAKNTPRCLESNPGRHAECDTALGDA
                     FGQDKDPLVEAAERVPRTTVVDLTPWLCVGDVCPAVVGNVVVYRDNHLTDSYVRTLYGP
                     LTAGLGLV"
     gene            17493..18971
                     /locus_tag="CVV72_RS07600"
                     /old_locus_tag="CVV72_07565"
     CDS             17493..18971
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013714.4"
                     /locus_tag="CVV72_RS07600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07565"
                     /product="FAD-binding oxidoreductase"
                     /protein_id="WP_219151694.1"
                     /transl_table=11
                     /translation="MRALRAEPERAIAMTKNRSASLAPAELAAWRSKSTGDVLVSADPG
                     FDQIVAEDVVVATPAVIVRPATAGDVGRAVSFATEHGLPVSVRGGGHGPFAVGDGDLLI
                     LLSALDEVRVHDDGQVEVGGGAVWGQVAHALRPHGLALSSGDTSSVGVGGLTLTGGVGW
                     LVRRHGLALDNLVAAEIVTASGQVLAIDAEHHADLFWAIRGGGGNFGIVTRFTFQAHPL
                     PGTVRYGTITTAKPSTATGMAELLGRWRDVLHTADERLNSTVFVMPPEERSPANCQFFV
                     LWGGDDEDEARAAIAPLLELPGILHTSFDFRPYVSVLEDGGEPDALEDILESVSVDAPE
                     PDAYIDDVVSDEHNAFVVLDDGVIASLAELIVQAPGSILSIRSMIGAVNRVPPTATAFG
                     WRDTEALVIFTGILPPGSGPQDIVRIEEQWSAISAGRGSYGNFRDQVDDPFTHRVYAPV
                     NTERLIETKRRWDPENVFAGNHNIKPRPAHADDV"
     misc_feature    17536..17549
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.04"
                     /tool="antismash"
     gene            19141..20463
                     /locus_tag="CVV72_RS07605"
                     /old_locus_tag="CVV72_07570"
     CDS             19141..20463
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1247: acetylornithine deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005164792.1"
                     /locus_tag="CVV72_RS07605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07570"
                     /product="M20/M25/M40 family metallo-hydrolase"
                     /protein_id="WP_219151695.1"
                     /transl_table=11
                     /translation="MTEPNLIEAAAEEAVTLTSELIRIDTTNTGDPDTLVGERAAAEYV
                     AEKLTDAGYEITYVESGGKDRHNVIVRLAGADPSRGALLIHGHLDAVPADASEWSVHPF
                     SGAIQDDYVWGRGAVDMKDMCGMALALARHYKINGIVPPRDLVFAFLADEEAGGKYGAQ
                     WLVENRPELFEGVTEAISEVGGFSITLKDNVRAYLIETAEKGIRWMKLRVRGTAGHGSM
                     IHRDNAVTKLSEAVARLGNHRFPLVMTDSVREFLDGVTEITGWDFPEDDIEGSVAKLGN
                     ISRMIGATLRDTANPTMLTAGYKSNVIPSVAEASVDCRILPGRLEAFNAELEEILGPDI
                     EKEWMELPPVETTFDGALVDAMTNAVLAEDPGARTLPYMLSGGTDAKSFQSLGIRNFGF
                     APLKLPADLDFSALFHGVDERVPVDALKFGVRVLDRFLRSA"
     gene            20463..21344
                     /locus_tag="CVV72_RS07610"
                     /old_locus_tag="CVV72_07575"
     CDS             20463..21344
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-274). E-value:
                     6.1e-25. Score: 80.2. Matches aSDomain:
                     nrpspksdomains_CVV72_RS07610_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029599.1"
                     /locus_tag="CVV72_RS07610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07575"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_219151696.1"
                     /sec_met_domain="PF00561 (E-value: 8.2e-17, bitscore: 60.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.9e-21, bitscore:
                     74.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPGLLAADGTPLHFDRWGDPSAPVTVVLLHGYALDRRSWRAIAPV
                     LAEASPEEPLAVVAYDQRGHGESGEVRASSATMGKLADDLAEVLDKVVPDGKVVLVGHD
                     MGGLAILSLAQRHPDVFAARVAGLGLLAMSAGGVTPDAIWPNALGKLGRDLEIVFGTRL
                     IGLVREHTSKAVTAGLRWWLFGDDPVPADVELTVRMIRGNWPQTVSAFRPALDAYTRES
                     ALSQVGAVPVTAIVGERDKLVPTADVEELAGAVENGTAVVLPGVGHVVPLEAAPQVIPR
                     LLALANQARRQS"
     aSDomain        20535..21284
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS07610_Abhydrolase_1.1"
                     /evalue="6.10E-25"
                     /label="CVV72_RS07610_Abhydrolase_1.1"
                     /locus_tag="CVV72_RS07610"
                     /protein_end="274"
                     /protein_start="24"
                     /score="80.2"
                     /tool="antismash"
                     /translation="TVVLLHGYALDRRSWRAIAPVLAEASPEEPLAVVAYDQRGHGESG
                     EVRASSATMGKLADDLAEVLDKVVPDGKVVLVGHDMGGLAILSLAQRHPDVFAARVAGL
                     GLLAMSAGGVTPDAIWPNALGKLGRDLEIVFGTRLIGLVREHTSKAVTAGLRWWLFGDD
                     PVPADVELTVRMIRGNWPQTVSAFRPALDAYTRESALSQVGAVPVTAIVGERDKLVPTA
                     DVEELAGAVENGTAVVLPGVGHVVPLEA"
     misc_feature    21345..21358
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.88"
                     /tool="antismash"
     misc_feature    complement(21346..21359)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.26"
                     /tool="antismash"
     gene            21385..21981
                     /locus_tag="CVV72_RS07615"
                     /old_locus_tag="CVV72_07580"
     CDS             21385..21981
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007029600.1"
                     /locus_tag="CVV72_RS07615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07580"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_219151697.1"
                     /transl_table=11
                     /translation="MFSVAVIEDAEAAEVSLDPVRARLLAELAEPASATMLAARVDLPR
                     QKVNYHLRALEKHGLVELVEERRKGNVTERMMRATASSYVISPTALSAVQPDPAQSPDR
                     LSARWLLAVAGRLVRDVGLLITGATKARKRVATFAIDGEVRFSSAVDRAAFAEELTVAI
                     TNLVSKYHDEGAEQGRDHRIVVAVHPSVRTEPEER"
     gene            21982..22725
                     /locus_tag="CVV72_RS07620"
                     /old_locus_tag="CVV72_07585"
     CDS             21982..22725
                     /NRPS_PKS="Domain: Polyketide_cyc2 (4-119). E-value:
                     5.2e-11. Score: 35.1. Matches aSDomain:
                     nrpspksdomains_CVV72_RS07620_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635675.1"
                     /locus_tag="CVV72_RS07620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_07585"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_219151698.1"
                     /transl_table=11
                     /translation="MGHEFEITDRVEVDATPEQVWDAIATGPGITSWFMGRNEVDGGVG
                     GTVKTAFGGFEPTSAITSWDPLERLVYGTEPAPDGRFVAYEFLIEGRSGGSTVLRTVTS
                     GFLPGDDWEDEFEAMTAGGELFLRTLVEYLNRFAGRKAVPVTVFGPMIEDWDSAWLTLG
                     RELGLAGRPQAGDRVRLSTGPLSTVDGEVYFANAQTVGIRTPDALLRFVRGFTGPICAM
                     HHLFGDVGSAEQDALWAEWLGRVFK"
     aSDomain        21994..22338
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS07620_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="5.20E-11"
                     /label="CVV72_RS07620_Polyketide_cyc2.1"
                     /locus_tag="CVV72_RS07620"
                     /protein_end="119"
                     /protein_start="4"
                     /score="35.1"
                     /tool="antismash"
                     /translation="FEITDRVEVDATPEQVWDAIATGPGITSWFMGRNEVDGGVGGTVK
                     TAFGGFEPTSAITSWDPLERLVYGTEPAPDGRFVAYEFLIEGRSGGSTVLRTVTSGFLP
                     GDDWEDEFEAM"
ORIGIN
        1 gcgatcgcgc tcaagtccgg ctcggcgaac tccccggtgg cgtcggcgag ctacacgatc
       61 ggatcgacac aggcgacctg tccggcccag gcagaggtcc cggacttcgg cccgaacgtg
      121 cggatcttcg accccggtat gtcggcgtcg acgatccagg ccaagctcga cgcggacttc
      181 aatgcgcaga aggacaccct gaccgcgcag ttcaccgaac gccggtacgc gcacctgttc
      241 aagcccggcg cgtacaacgg catccacgac aacgtcggct actacacctc cgtcgcgggg
      301 ctcgggcaga acccgggcga cgtcgtgatc aacggcgacg tgaccgtcga cgcgttcaac
      361 gagtcggaca agggggtggc gctgcagaac ttctggcgtt cggccgagaa cctggccgtg
      421 gtcccgagta gcggctcgac ccgctgggcc gtcgcgcagg cggcgccgtt ccgccggatg
      481 gacatccgcg gcgggctcca gctctacccg gccagctacg ggttcgccag cggtggctac
      541 accgccgaca gcaaggtttc cgggcagacc gcgtcgatct cgcagcagca gtggtacacc
      601 cgggacagca gttacggcag ctgggacggc ggggtctgga acatggtctt ctccggcacc
      661 agtggtgctc ccgcgaacac cttcccgaac ccgccggaga cgacgctcgg caccacgccg
      721 gtgtcccgcg acgtcccgta cctgtacctc gacggctccg gcaggtaccg cgtattcctg
      781 ccttcgttgc gcaccaacgc ttccgggccg agctgggcca acggtggcac cccgggcagc
      841 tcattgccga tgagccagtt ctacgtggtg aaggcggggg acacggcggc gtcgatcaac
      901 accgcgctct cccagggctg caacctgttc ttcactccgg gcgtctacca cctgaaccag
      961 acgctcaacg tgacgaaggc gaacaccgtc gtcctcggcg tcggctatcc gaccctggtc
     1021 ccggacaacg gtgtcgacgc catgaaggtc gccgacgtgg acggcgtccg gatcaagggc
     1081 ctcctgttcg acgccgggac gaccaactcg cagtcgttgc tcacggtcgg ccaggcgggc
     1141 tcgacggcga accactccgc gaacccgacg accctgcagg acgtgttctt ccggatcggc
     1201 ggccagatcg cggggagggc gacgaacagc ctgatcgtca acagccggga cacgatcatc
     1261 gaccacatct gggcgtggcg ggccgaccac ggcaacgcgg gcacctacgg ctggacggtc
     1321 aacaccggtg acaccggggt ggtcgtcaac ggcgacaacg tgctggccac cggcctgttc
     1381 gtcgagcatt accagaagta ccaggtgatc tggaacggcc agaacggcag gacgatcttc
     1441 ttccagaacg agatcccgta cgacgtcccg gatcaggcag gctggagaag tcccaatggg
     1501 ctcaacgggt acgccgcgta caaggtgggg gacaacgtga cctcccacga ggcgtggggc
     1561 ctgggcagct actgcttctt caacgacaac ccgtcggtga acctgtatca cgcgttcgag
     1621 gtgccgaacc gcgccggcgt gcggttccac aacatggtga cggtctcgtt gaactacaag
     1681 gggaccatca cccacgtgat caacgacgcc ggggcggtga cgccgccgga cacacggccg
     1741 agcaacctgg tgagctaccc gtaacgctcg tcgcctgaag tacgtgaagc ccccttcact
     1801 gcgctagacg caatgaaggg ggccttcacg tactcaggga aagtcgcttc gtgtataacg
     1861 aactataccg ctcggctgag gagggctcag cgccctttcc gactgccttc gtaggcccgc
     1921 tcgcgtagac cggtgagcca gcggggccgc agctcccagc ccggtggcaa attaagcatc
     1981 ggatcgaagg cgggctgagg ggagtcgtcg tcgacttcgt ggagggtcag cgtcgcgcaa
     2041 ggtttccgat ggccgttcgc gcggacggtc tcgacgaggt aggtcaccgg tccttccgcc
     2101 accagccgcc gcaaaccgtc cagcgacgct tcgacgttcc gggccgcctc cgcgcgggcg
     2161 gccagccaga ccagtccacc cttcgtgcga tagggcagca acgtgctgta ccggccgctg
     2221 gtccaggcgc gctccggtcg cggcagcacg cggccggcga gaccggtgcc cgaagtggtc
     2281 aacgtgagat cccacggatg acctccgacg gcggggatcc gcaccgccat gcccagcgcg
     2341 tcgggtacgc gccccgggag accggcgccc ttggacatcc gcacggtgac ggccaccggc
     2401 tcctccggca gggcgaggtc gtcacgcctc aaagcctgaa gttcgccgtt gaacagtagg
     2461 ccgttcgggt ggaatgcccg cgcaccacga agtgccgcca gtgcatgaaa tccggcgtgg
     2521 aaaagcttgc cgaccggccc tgcctgcggt gccttctcct cggccacgat ttccaccctc
     2581 cttgtgacgt gtgtgcttcg caggggctac cccgggtgcg ccgggttaca cgggaattcc
     2641 cacgaattcg aaaacgccga ttcccccggt gtgaccggct ttcgcccggg tactcgcgtg
     2701 atgttcgccc atcgggcgtc cgacagtcct tccacctgga tcggaggaaa ccaatgactg
     2761 catcgccggc cacggttcgg cgggctccgc gccagctcat cgccctcggc gtgggcgcgg
     2821 tcttcctgct cgtcggcatt ctcggcttca tccccggcat cacgacgaac tacgagcagc
     2881 tgagcggcgc cgggcacgag tccggcgcgt tgctgctggg cgtgttccag gtgtcgatcc
     2941 tgcacaacat cgtccacctc gcgttcggcg tcgcgggcat cctgctggcc cggacggtga
     3001 ccggcgcgaa ggcgttcctc gtcggcggcg gggtgatcta cctcgtgctc tggctgtacg
     3061 gcctgctgat cgaccacggg tcggcggcga atttcgtgcc ggtcaacacc gccgacaact
     3121 ggctgcacct cgggctcgcc gtcgggatga tcgccctcgg gctcattccg ttctccggtt
     3181 cgaaggcgcc gatcgccgac tctcgctagc ccgtttctcc cctgaaatct ctggaggtag
     3241 tcagtgttcc gtcataccaa atcgctccaa ttcgaggcca agccggaaaa gccggatgcc
     3301 ttgtacgccc gcaaactgca ggagctcatc ggcggtgcct acggtgaaat gactgtcacc
     3361 atgcagtacc tgttccaggg ctggaattgc cggatcgagg gcaagtacaa ggatttgatc
     3421 atggacacgg cgaccgagga gatcggtcac gtggaaatgc tcgcgacgat ggtcgcccgg
     3481 ctcctcgaag gggcacccgc caccacggtg gccgaagccg cgaaggatcc ggccaccgcg
     3541 gcgatcctcg gcgggatgga ccctcagcag gcgatcatct ccggtggcgg tgccacgccg
     3601 agcgacagcc agggctatcc ctggaacggc cgctacgtgg tggcgtcggg caatctgctg
     3661 gccgatttcc gggcgaacgt ggcggcggag gcgcagggcc gcttgcagac ggcccggttg
     3721 tacaacatga ccgacgaccc cggtgtgaag gcgatgttgc agttcaacct cgcgcgggac
     3781 acggtgcacc agaagcagtg gctcgccgcg atcgaggaac tcaaggccga cggcctggaa
     3841 agcgacatcg cgccgacggc gttgttcgac gaggagaacc aggaccacaa caacaccgtt
     3901 tggcacctgt ccgacggtcc ggacggtccg aagggtggct ggagcttcgg cgaagacggg
     3961 atcgagtacc tcatggaacc cgaggcactc ggcggaccgg gcaccgcccc gaaacccgat
     4021 ccggcgcttt acggcaccta cgcgccgctg caggacgcgg tcgggacggt caaaggcaag
     4081 gtcaaggacg ccaagaagaa ggccaccaag tcgagcaaga gttagacctc agccgccagc
     4141 cggcgcggaa ggtccgtgaa gcccccgaaa gtcaggggca cggcaaagcc gcataaccgc
     4201 tggtcaggcg ggtcgtaagc ggtgattccg gcgctcgtcg gaatcaccgc tcttcgtccg
     4261 ggcgggtgag cgagcccccc agaccactca cggaaccgga tccggtgatt ccccaggcca
     4321 tggccacaat ggccgattca gtgcgccgtc acgcagttct cacggagcgc tcacgtcagg
     4381 aaaggaaacg gagaaggaca caccgcactg gggctaatgg gaacgccgct tgctcatgtg
     4441 gcccggccgc caggaaacgc cacgacctcg ccccgccccg gtcggttaaa cgcgtgctcg
     4501 gtattagttc cactcgtttc acgtacacgg tggtcaccga cgcgtagcct gaccccgtgg
     4561 aggagtttcc tgacccgtcg gggccaccct acccctacaa atacccgctg cctgccgagg
     4621 cgaaggcgga gcatcagcgc gccgtcgagt acttccgacg gaagtatgcg ttctgggaca
     4681 gcatgatgat gccctcgatt tcggtgggcc tggtcgcggc cggggtgttg tccgaggacg
     4741 acgaaggcta cctgtcggtg ccggtgcttc tcggtgtgtt ggtggtcacc ggcgttctga
     4801 tggccctcat cggtctccgg aaggatgctc tggcggacaa aagagacaag catgtgaatc
     4861 tgctgaagac ctaccgcgtc ttgccacacg agatcgatgg atcggcatct gcgacgctac
     4921 cttcggactt cgacacgaac cgcgaccact tcggcgcgcc tctccctggc aaggcggatc
     4981 cgtgcccccg cgcgatgcct gactccacac ccgccatcga caaaatcccg ggcgaaaatc
     5041 cctacaacgg gatgatccgg ctcagccctc ccaagccccg tccggaaagc ggcccttgat
     5101 gaacgggccg gcgggcttgc tccatctcct cagttcaggg cccattccgc ccgccgtccg
     5161 tcgccggtag gggtgtcgac tgcccgatct gttcgaacac caacgcaaca gcacgttccc
     5221 gcagctcagt acatcctcac tcacacgagg agcctccatc aaacccgggg aggtgcaccc
     5281 tgcaagtagg gaaggaggcc ttcacggacg aacgccggcg gcgggtcagt cgtcggcttc
     5341 ggcgaccgcg gccgcttcgt cgtcgtccat cgccttggtg tcacgcgggg ggaggaaggg
     5401 ttcgtcgtcg gccggggagc cggatgcgat ctccttgcca cgcgcgagtt cggcgtccag
     5461 ttcggcgccg aggaggacgg cgatgttcga gatccacatc cagatcagga acacgatgac
     5521 accggcgagc gaaccgtaga ccttgttgta cgagccgaag ttgccgacgt agaaggcgaa
     5581 cccagccgtg gccgcggccc agagcagcac ggccacgagg ccgcccgggg tcagccagcg
     5641 gaatttcggc tgccgcacgt tggggctcac ccagtagagc atcgcgaccg ccagccccgc
     5701 cagcaacgcg atcaccggcc atttcgcgat gtcccagacg aggacaccgg tcgagccgag
     5761 gccgatcagg tcgccgaggt agcgggcgat cccgccggtc gccaccaccc cggcggcaca
     5821 cagggcgagc acgaccagca cggcgatggt gagcccgatc cgcaacggca cggtcttcca
     5881 gatcgggcgg ccttcgggca tcgagtagat gacgttggac gcccgcatga acgcgccgat
     5941 gtagccggac gcggaccaca acgcgcccgc ggtgccgagg atcgccgccg ttccggccag
     6001 cccgccggtc ttggacagct cttcgatggc gccgaccagg atgtcccggc cctgacctgg
     6061 tgctatccgg ctgacattct cgacgagtgc ctgggtcgcc gacggaccga ggagcccgag
     6121 gatcgcggtc agtacaagca aaccggggaa gagggaaagc acgccgtagt aggtgagcgc
     6181 cgccgcccag tccagcatgt tgtcgcggtt gaactggacg aacgtccgtt tgagcaccgc
     6241 ccaccacgat cgtcgggaca attcggtggg accgtccggg tctttcgcta tggcagccaa
     6301 gggaacctcc tgctggggat tccttggctt acccggtgtc gccggggcga aacgggtggt
     6361 caggccgggc gggatcgtgg cggcggtggc ggcgggaccg tcttcgccag cacgatgtcc
     6421 gccagccgga tcgtcgcgag cccgcgtttg gtttcgaccg tgcagtcggt gtcatcacgg
     6481 gagcggaggt agccgagcgc gtcggtgaac ccgccctcga tccggtaccg gacgacgact
     6541 ctggtgccga ggggcacctc cggaagggtc atcggttcag gtgcgcggtg agctcgtcgt
     6601 cgctcggctc gaccaggtgg gtgccgtccg gccagacgat ggtcgggatg cgtcgctcac
     6661 cgttctgcag cgcccgaacg gtctcctcgg cgccggaatc cgcttcgacg tcgatgtagt
     6721 cgtactcgat gcccttcgag tccaggaggg cgcggctgcg tttgacgtcg gggcaccaac
     6781 cggcgccgta cacggtgagg tcgctcatgg atcacagcat gccaggtcgc ggtccgccgg
     6841 cgtgttcggc gagggctgcc cggtcggcga ggccggtctt ggcgagcagg ctcgcgacat
     6901 gcttctcgac cgtccgcggc gagatgtgca ggcgggcgcc gatgtccttg ttgcccatcc
     6961 gctcggcgag cagcaccagg acctcgtact cgcgcacggt gacgcccgaa gcccgcaggt
     7021 cacccggtac ccggtcgacg ccggagcggc gttgccggac gggtgcgccg agtttgcgca
     7081 ggaggctccg gcaggcggcc gcgaccgccg ggatgtccct gcgatggaag tactcttcgg
     7141 cctctttgag ccagcccgcc ggatcacccc agccgtcggc ggcggccggt tcggcgatca
     7201 gccggagccc gagatggcgg gccaggggat agggcgccga cgtctccagc gccgaggcca
     7261 ccgcctgtgc ggccgccgcc gcgtcacctc gcctgccgtg ctcgaccgcg tgcgcgaatt
     7321 cgacgaactg ccggttccag cgcatcccgc tcacggcgga gccgtcctcc ggacagggca
     7381 cgcccccgag cgtgtcgacg agtgtccgga gcccgtgctg gccggcgagg tggaaccggc
     7441 tcggccgccg gtcctccagc tcgacgacct ggccgagttc gcggcgggcc cggtcgaagt
     7501 cctcctcgag cagcgaacag aagacccgcg ccagcccgat gctgagcacc atctcctgcg
     7561 cgttctcgcc gccgctgtcc cggaagtcgt cgagtgcctg ctccatcgcc gggcggtccg
     7621 cccggtgccc ggcggacatc gccctcgtca tatgggcgta ttgcagcaac gcggtcaacc
     7681 ggagcctgcc cagcacggcg aggttctcgg ccagcaacgc gtgcgcggtg ccgaattcgc
     7741 agcgcaggat cgcgtgcatg gtgcgcacgg aatcgaccgc gcagtgcagg gtaatcgacc
     7801 cggtgcgctg agcgtccgcg cgggcgagca gcagggtctg ctcgtcgccg ttcatcagca
     7861 cgcgatgccc gcccagccgg accagcgcct gggtgcgcag gtggtggaga tggttgtcct
     7921 cggcggtccg ccgagcgagc tgcatgtagt gctcggattc ggtgaggtcc cgcgacagtg
     7981 cgagcatgcc gagcacctgc agcgcctggc agacgacgaa cggctgctcg gtcgcctcgg
     8041 ccacttccca ggcctggcgc gcgagccgtt ccgccgtgcc cgcccggccg ggaacgtcca
     8101 gccagaggtt cgcttcgacg gcgtcgagcg cggcctgctg agccggtgag atcgccgaac
     8161 cgaggggagc gcgggcgcgt tcgatctggc cgaggcattc gtcgtgccgt ccggcgatgt
     8221 aagcggccca ggccagctgg gtatgcagtt tcgcggcccg ttcgagggtg ccgatctccc
     8281 cgaacgcggc ggagagctcg acggcgcggt cgaactgacc ggtctgcccg agcgcgagca
     8341 ccagcgtctc cagcacctcg gcccgatcac ccgcgtcggc cccgccgagc aggtcgacgg
     8401 ccttggtgag catcgtgacc gcggagtcgg cggcgccggc gtcgagggca cggcgaccgg
     8461 tttccgcgaa caggtggcct gccgcctgtt cgtccagcgc ggtcagccgg agcgacgcga
     8521 cgagcgcgca caggtcgccc ggcagccccg ggtacagctt ttcgacggcg tcggcggcct
     8581 gacgggcgag cgtcgccttc cgtgccggcg actggcgcgc cagcagcgct tccgcggtca
     8641 gcggatgacg aaaggcgtac cagccgggcg tcgtctcgtc ggtggtcacc aggttcgccg
     8701 agaccgcggc gctcaggtgg ttgtgcaggg tccggtcgtt ggttccggtg accgcctgga
     8761 ccaccgtcag cgggaagcgg cggccgatga tcgccgcgac cgacagtagt tcacccgcct
     8821 gctcgccgag ttgctccatc cggacgccga tactggtcac cagtgcggcg ggaacgcggg
     8881 cgcggagctc gccgatgacg cgccagccgt cgcggccctc gaccagcagt ccgtcgttca
     8941 ccatgccgtg gagcagttcc tcgacgatga acggaaggcc agcgctgttg cgccacaaca
     9001 gttccgccgc ggccgacgga agccgtcccg gctcggtctc gaggcaggcg gcggcgaggg
     9061 cgcgggtgtc cgagaggccg agcctgctca gttcgacgac ggcgcagctc atccgctgcg
     9121 caccggaggt cgccaggcgc agggcgtcgg agggttcgtt gcggagcgtg ccgacgaaca
     9181 gggcttgcgc cgcggacagg ttgtcgacga ggtattcgag aatgaacagg gtttccgcgt
     9241 cggcgtcctg gagatcgtcg aggacgagga gcgcgccgcg gtcgcggccg gtgacggcca
     9301 gcagccggaa caccgcttcg gcgagcacca tcagggaacc cgaatcccgc ggccggtcgc
     9361 cccggcccca gtcggggatg agctgggcga gcacggggat gaacgggtcc agttcggccg
     9421 cggccggcgg gccgccgccg cggaaatgcg accacagtgc ctgggccagc ggccggaacg
     9481 ggacgagcgg gccgatcgaa ctggcccgcc cctgcaacac cgggatgtcg gcggcgaccg
     9541 ctcgtgaggc ggcctcgacg gcgagccgcg atttgccgat gccgccttcg cccacgagaa
     9601 agatcgcgcc gccgcggccc gcgacggcgc ggtcgagagc ttcggaaagc tcggccagtt
     9661 cggcgtcgcg gccgatcacc cgcgacgaac ggattcccac cgccgtgact atagcgagcg
     9721 gattcctccg tcacggccaa taaatgatca cgaaggcggg cggcgcgaac ccgccttcgt
     9781 gagcttctcc gctcagatcc agccgccggt gaagacgctg acgacggacg gcgaaccggg
     9841 gtccgtggac agggtggcga gcgggttggc gctcagccgc ggcttgccgc ccgccagcgc
     9901 gtggttgcgc gagccgacct cgagggcgcg cggcaggttc acggcgccga ggacgtcctc
     9961 ggtggcgggc agatctcttt cgtacatgcg gtttttctcc tcatactcga tttaccggcg
    10021 gaacaacggt ggccgcggga tgcggccggt cggggcggag caggagcgcg gaggggaccc
    10081 ggtcaccgaa tcccagccgc agcaggccgt agccgattcc cgccaggccg ctcagcagcc
    10141 cgggggacgg gaccgcgccg ggagtcccgc agcgggcacc gcgctggtcg atggcggcga
    10201 gcagatgacc ggtccggcgg cgtaccgcgg cggcggcgcc agtgtgcccg ttctccgcca
    10261 gcacgcacaa cacttccagt actccggact cgccgtggca gaggctgaga tccttcagcg
    10321 gtgccccgtc ggccagccgt ttgatcgtcc tggcgaggtc cctggcatac gcgggatcgg
    10381 gcaggtgagc ggcaaggccg agcgcgtcgc ccgcgagacc gtcgcaccag ccgacggtgc
    10441 tttccgcccg atcgtccgcc tttccgggcg gttcttcgcc ggaacggtcg tgtgcccgca
    10501 gtacccagtc gatcccggcc gaaccgcggg cgaacgatct ttctcgcgga cgttcgcggc
    10561 cgagcagttc tccggcgtac cggtccgccc gtgccagtgc cgagtccagt cctgtttgga
    10621 catacaccga ccgcatcgac gcgacaccgc ccgccagccc cgtcgtgaac ccggagggcg
    10681 tttcgggagt cgcgtccggc atgaggtcga cggcctgctc gatgagatcg ccggcgggaa
    10741 ggccgaccag cgtgctgagc cgcgcgatcg tgtacgcgac gccgccgagc ccgagaaggc
    10801 cgccgcagcc ggcggtggcg gccagctcac ggtcggcgcg gagagtggtg aagaggccgg
    10861 ggagcgggct gatcgcgtac gcggccaggt cgcggtatcg cgcgatcccg gtcagttcgg
    10921 cgagctgggc gaggaacagc gcgacaccgc agtagccctc cccgagcccg gcgcccatcg
    10981 gcagcacggt ccagtagcgg tcgtcgacga gttcgatccc gagccagttg gagcggtgtt
    11041 cgtcggagaa ggcgttggcg acgatctggt cggcgatgcc gcaagcggtg accagcagtc
    11101 gttccgggtc gggtgcctgg ttcggtgccg ccgtctccgc ggtctcggag ccgccgtggt
    11161 ggcccgcggt caccgtgctg atggcgagcg tggccgaaat cagccattcc tggtcgcgtt
    11221 ggtcgagcgg atccatgtcg gcgagcttcg cctgcacggt cgccagcgac ggccggtcga
    11281 ccactccgtc gacgctctcg ccccgtgaat ccagcagcga cgtcgagccg gggtgcgagg
    11341 tgaacatcgg cacgtcgccc gcccagaggt cgtcccgctc gtggggcacg aggcggagca
    11401 gcttctcctc gtcggcggaa tcctgttcga gcaggtcgaa cgcgcggtcg cggtcggcgg
    11461 cgtcgcgaag caggtcggga tgggtggtct cgtccagcag ccggaagtag aagttcgtcg
    11521 gccggatcag cacccggatg ggatcctcgg cgcagcgccg gaggtgctcg gcgagttcgt
    11581 ccctgccggt cgagatcgcg tcgtagccga gccggaatcc ggccagcagc gcggcactgt
    11641 gctcggtggg cgggatgtcg cggccgtcga gacgcggcag gttgttcccg cccgcgagtt
    11701 cgccgggcac ccgcaccagc cgcatgcggt cggtacccgg atcggcccac tcgatgcggt
    11761 cggtgggcag cttgccgccg cggccggcga ggccggagat gtcgacggcg ccgtgttccc
    11821 cagcgaagag ctgggggagc agcagcgtgc gctgcaccga tcgtgccagc atcgcggcgg
    11881 cggggtcgcc ctccggcgga tcgggtggcg acggctggaa cagcgtctcg atgtcgatca
    11941 gcaccggctg gtcgccgcag gcgatgatgt tctcgtagtg gacgtcggtg gcgtcgagcg
    12001 cgtacaggag cgccaggagg atgccttgcc gccggtagaa gcggtcgacg tcgccgatgt
    12061 cggcgcacgg ccggtgctcg acgaaccgga gccagccata gccctcacgc ggcaacgcgt
    12121 ccgcggtccg gagttcgagc ccgggcagcc gtttgttcag gtgctcgacg acgtcggtga
    12181 accgttcgtg caggatcagc ggccggggtt tgtagatcac cttggcaccg ctggagaacc
    12241 ggagcagttt gaccgagcgc ccgcgtgcgt gcgagtcacc gatcccgccc gcgacctcga
    12301 cgagtgtgcc gagttcgccg tcgacgaccg agcagggcag taaggcggcg tcggccgaga
    12361 accgggccag cgtttcggcg ttggcttcgg cggcgtgcag gcacgcctgg gcgacgaggc
    12421 gggccagtac cgggtactcg ccgaacaacc ggacgagccc ggccggagtg gctagccgtc
    12481 gcacgaaatc ggagaagcgc tcttcgggcg tctcgccccg gaggtttccg gccttgcggt
    12541 cgcggtggag ttcgaggacc aaggtgcgga ccgcgagggt gagcagatgg cggtcgagtt
    12601 gggccgcgaa cccccggcgg agggcctccg catcggcgcg ggggagatcg tccgggaccg
    12661 cttcacgcga agcggcgtgg acgaacgacc tgaagacccc ggcgaactcg acacgccagt
    12721 caccgactgg gggacgctcc ggcagaagcg cggtgatggt gcgttcggcg aagtccgccc
    12781 atgcgggctt gtccgctgtc cgttcgcgcg gggtctggcc gtgtacccac cacctcggcg
    12841 gcagggacgt cgccgatgct gggggcgtca cggcggtcat ggtttcagtt cggccgggcc
    12901 cggcacatgg gggccgaacc cccacattca gcgcacgcac gaagatgtcc ggagagtgac
    12961 ggacgaggga gtcttcagcg gaatatgggg tccaggcacc catgcgcggg gaccggtccc
    13021 ggccgcacca tggtcgggtg gcgcggaact cgggcgcggg ccggttactg ggggtccggc
    13081 ccgcgtccgc ccggaaccct tgagaattga cgcactttcc ttttcagtgg ttaaaaaccg
    13141 gaacccggta aagagacacg gtcgtgtccc tttaccgggt cgcaaacacg aggggccgac
    13201 ccgcgccaac agattggccc ccgtcaaccc tgtgcttaga gcgtcagacc agccatccga
    13261 gcacgtgggc caggtgcgcg agcagacccg agatcaggtc gtggccgtgg tgcacgtgct
    13321 gggtgaacat ctgcattgag gggctccttg tatcggattt cgtgttcggt tgtgctctcg
    13381 cgaggagcga tcgaagattt gcaccacgtt ggcacgctgt caaaaaacga tttcctgggc
    13441 cctcggcggg tcgtgaatct tcctacgata aacacgtaag tctttcgtgt tttgcgccag
    13501 ggcgggcctc gcgggcgatg acactgtgcg tagccagctc caggttggcc gatgtggaat
    13561 ctaagcctcc gctacggcaa gcggggggcg cgtgacacga atcggtgatc cacacgccac
    13621 gaatggtaag tcggcgagaa tcaccgatac gggtgacgcc accccacgtc cgatagcacg
    13681 aaggaagacg cttcgctccg gccgattgcg ggacggtgat cgttcacgca ctcaccggaa
    13741 atggggtttt cccgtgtttc gtcgaacaat cgcgaccgtc tccgtcgcgc tggcgacagc
    13801 gttcgggctg accgtggcgg cggattcggc cgcggccggc accgtcaccc agaccttcgc
    13861 ctgtcatccg aggcttgcca gccagaccgt gcacgtgact gtcaccgcgc ccgccaccgt
    13921 gaaaaagaac gtggaggctg ccgtttccgt caaggtcgaa aacgtccagc cttatccggg
    13981 gccgggttca ggtaggccct atacctcagg ccggctcgtc ttgggcggcg ccggcagcgg
    14041 cactgtcaac ttctacctga gctcgccgac cgtcctcgag ccgggcgatc cgtggatcat
    14101 gcaggggacg gcgaaagtca ctttcaccag tacgggaacg ggcaccctcg cctcgaacgg
    14161 atacggcgtt cctccgtact acaactgcgg gcaggccgat ccgcccgtgg ccgagaccgt
    14221 gaccgtgcag ccttgagtgg aaaggactcc ccatgttccg tcgaaagatc gcggccgtcg
    14281 ccatcgcggt ggccaccggg ttcggcttga gcgtgacggc gggtaccgcc tccgccggta
    14341 ccgtgaccca gacctgccgc ccatacagcg gtccgagaac ggtgaacgtg acgatcaccg
    14401 cgccggcgac cgcgacgagc ggggtgcctg tgccggtctt cgtcaaggtc gacggcgtag
    14461 agccatggcc gaattcggag ttgtcggcgg ggtcggcccg gttggtcggc ttcctgcgac
    14521 agggaggggc gggcaccggc gaggtcaaga tcgacgtgct gaacaacccg gccacgatcc
    14581 cgaccggtgg tcacttcagc gtcgagggca cccagcaggt caccttctcg actcccggca
    14641 ccgtcaccct cgggctccac cgcttcggca agccgctcac ctactggtgg tgcgccttgc
    14701 ccgcggacga gcagccgccg gtggccgcga ccgtgacggt gaactgaccg cgcttcggtt
    14761 tcgcacccgg gctccggcgg cgcgaatgcg cgccgccgga gcccggcttc atcggctacc
    14821 gcttgatgta gaggtcccac gaccaggtcg acgcggagca gaagtaggcc gaccagcggc
    14881 cactctgctg gccggagtgg ccgttgagcc ggcagtcgcc ttccgtcgac cagctggact
    14941 cgtagtagta cctcggatcg acacccgcgc cggcaggctg cgcgaacgcg atcgtcgacg
    15001 ccatcgcgcc aaggacagcg gcggtcgccg cgatcttctt catcacttgt gaagccccag
    15061 ttctcttctt ggaacacgtg cgtgcacaaa caatcatgaa tcggacgcgc ttgtcagccg
    15121 aacggccgag ttcatctcca cgccccgtgt cgccaacggt gacccactgc actcgggagg
    15181 gtgaagacag gtggtcgatc gggtgatcta cgctcttggc cgagtggccg cctccgtccc
    15241 gcgcggccga agcgatgggg caggagggtg cggtgacgct cgcgcaggtc gaacaggcgg
    15301 ttccgcgggg agcggcgccg gccgggccac gtggccagcg tcgggacatc caggggttgc
    15361 gtgcgctggc ggtcggtctg gtgatcgtct accacctccg cccggaatgg ttgcctggcg
    15421 gcttcgtcgg cgtcgacgtc ttcttcgtca tctccggcta cctgatcatc ggcaccctcg
    15481 ccggtgaact gcgccgcacc ggcaccatcc gcctgcgcga gttctacgct cgccgcatcc
    15541 ggcgcctctt gcccgccgcg tcggtcgtct tgctgagcac cgtgttcgtg acctggctga
    15601 tcctgccgat ctcacgctgg cctgccgtca tgagcgacgt cctgacctcc gcgctgaacg
    15661 tccagaactg ggcgctggcc gcccagtccg ccgactacgc ccacgccacc gccgccgcgt
    15721 caccggtcca gcatttctgg tcgctcagcg tcgaagagca gttctacctt ttcatccccc
    15781 tggtcctgct cgtctgcgct cgcctggccc accgcgccgg gccgaaggcc gcccgtcagg
    15841 ccgtcatcgc cgtcgccctc gtcaccgccg cgtctttcgt gttctcggtg gtttacagcg
    15901 agctcgacca tggccgcgcc tatttcgtga cgcccacccg gatgtgggaa ctcgggctcg
    15961 gcggcctcgc cgcgatgacc gtgcatcgcg tccggctcaa gagcggggtc cggctgctct
    16021 tcggctgggg cgggatggtc gcggtcctgc tcggttcgtt cctgctgacc accgcgatgg
    16081 cgtttcccgg ctacctcgcc ctcctgccga cgctgggcac catcggcttg ttgctggccg
    16141 gcaccgtcgc cgcggaccag cgagtggcgc gcccggaagt ctcggtcgtg ctggggctcc
    16201 cgccgctgcg ctatctcggc gacatctcct acagcctgta cctctggcac tggccggtga
    16261 tcgtggtggt cctgcagctc gcgggcagca cggaactgac gcggcggcag gcggtgggtg
    16321 tcttcgtgct cagtctggcg ctggccatgg tgagcaaaca cctggtcgaa gacgccttcc
    16381 gcggcgggag gaccacgcct ttccgccgcc gcacaccccg gctccgcagc gcatacctgc
    16441 tcggagcggc cttggtcgcg gtcacggcgg tcgccgcgac ggtaccgtgg cagtacgcct
    16501 cggcggagct cgagcgcctc gcgtcggccg ccagactcga tgaaggccac ccgggcgctc
    16561 tcgcgctcga caaggacaac ccgagggcga caccggacgg tgtcccgctg actcctgacc
    16621 cggcagtggc gacgcaggac tggccgctga gggacctgtc cgtcaactgc accgtgtacg
    16681 acatcgagaa ctggccgccc accggtgaca agtgcatcta cggcgcggcg accgcgccga
    16741 agacgatcgt gctggtcggt gactcgcacg cggcgatgtt cagtaccgtt ttcgcgcggt
    16801 tcgtgcgcga gcatccggag tggcgggtga agatgatgct gcgcaacggc tgccccttca
    16861 ccgccgtcgc accggccggt ctcaccgtct gctccgacca gaacgaactc gaactcgccg
    16921 gaatcctcgc catgaagccg gaactcgtgg tgacctccgc gatgtcccct gagtcctatg
    16981 acaaggacct gaaatggcgt tgggaatcgc gtgcgcagac cgtggacggt tacgagacga
    17041 tgttgcggcg tatctcggac gctggtatcc ggaccggcgt gatccgcgat gtgccccggc
    17101 cggccaagaa caccccgcgc tgcctggaaa gcaatcccgg ccggcacgcg gaatgcgaca
    17161 cggcccttgg tgacgcgttc ggccaggaca aggatccgtt ggtggaggcc gccgaacgcg
    17221 tgccacgcac gacggtcgtc gacctgacgc cctggctctg tgtcggcgac gtgtgcccgg
    17281 ctgtcgtcgg taacgtcgtg gtgtaccggg acaatcacct cacggactcg tacgtgcgga
    17341 cgctctacgg gcccctgacc gcgggactcg gcctggtatg aggtcgcgag ccctgggatc
    17401 cggtgggcgc tgcagcgaaa gctgaccacc atcaccgacg gtaacgcgac acgtgcttgt
    17461 ttacaatgta tgctcgggct ggctgatgga ccttgcgcgc gctccgtgcg gagccagaaa
    17521 gggcgatcgc catgacgaag aaccgttctg cctccctcgc gccggccgag ctggccgcgt
    17581 ggcggagcaa gagcacgggg gacgttctcg tgtccgcgga ccccggcttc gaccagatcg
    17641 tcgcagagga cgtggtcgtt gccacgccgg ctgtgatcgt gcgccctgcc acggcgggtg
    17701 atgtcggccg agcggtcagc tttgccaccg agcatggcct gccggtgtcc gtgcgcggcg
    17761 gtgggcacgg acccttcgct gtcggcgatg gcgatttgct gatcctgctc agtgcgctcg
    17821 acgaggtacg ggtccacgac gacggccagg tggaggtcgg cggtggcgcg gtctggggac
    17881 aggtcgccca cgcgctacgg ccgcacgggc tggccctgag ttctggggac accagctcgg
    17941 tgggggtcgg tggactcacg ctcaccggtg gcgtcggatg gctcgtgcgc cgccacggcc
    18001 tggccttgga caacctggtc gccgccgaga tcgtcaccgc gtccggccag gttctcgcca
    18061 tcgatgccga gcaccacgcc gatctcttct gggcgatccg cggtggcggt ggcaacttcg
    18121 ggatcgtcac ccggttcacg ttccaggccc atcctctgcc cggcaccgtc cgctacggca
    18181 cgatcacgac ggccaagccg tccaccgcca cggggatggc cgagctgctc ggccgatggc
    18241 gcgacgttct gcacacagcc gatgagcggt tgaactccac cgtcttcgtc atgccccccg
    18301 aggagcggtc cccggcgaac tgccagttct tcgtcctctg gggtggcgac gacgaggacg
    18361 aggctcgggc ggcgatcgcc ccgctgctgg aactccccgg aatcctccac accagcttcg
    18421 actttcgccc ctacgtgtcg gtgctcgaag acggcggcga gcccgatgcc ttggaggaca
    18481 tcctggaaag cgtctcggtc gacgcgcccg agccggacgc gtacatcgac gatgtcgtgt
    18541 ctgacgagca caacgcgttc gtcgttctcg acgacggagt gatcgcgagc ctcgccgagt
    18601 tgatcgtgca ggcgccgggt tcgatcctga gcattcgcag catgatcgga gccgtcaacc
    18661 gggtgccccc cacggcgaca gcgttcggct ggcgcgatac ggaggccctg gtcatcttca
    18721 ccggcatcct gccaccaggt tcaggaccgc aggacatcgt gcggatcgag gagcagtggt
    18781 cggccatcag cgccggccgc ggcagctacg gcaacttccg tgaccaggtc gacgatccgt
    18841 tcacgcaccg cgtctacgca cccgtcaaca ccgagcgcct gatcgaaacc aagcgccgtt
    18901 gggacccgga gaacgtcttc gcgggcaacc acaacatcaa accgaggccc gcgcacgccg
    18961 acgacgtgta gtccggcgtc agggggagct gtcgtgcgtt cctggaggcg ctcgttcctc
    19021 gagaggatgc cttcgagtgg ccgcccagtt acgacagatg acggggaagt gggtcttcac
    19081 accccgtcca ccacgcggtg gcagcgggtc ggcaggctcc gccaatggta ggaatgcctg
    19141 gtgaccgaac cgaatttgat cgaagcagcc gccgaagagg cagtcaccct caccagtgaa
    19201 ctgatccgca tcgacaccac caacacgggt gacccggaca cgctggtcgg tgaacgcgcc
    19261 gcggcggagt acgtcgccga gaagctcacc gacgcgggct acgagatcac ctacgtcgag
    19321 tccggcggca aggaccgcca caacgtgatc gtccggctgg cgggcgcgga cccgtcgcgc
    19381 ggcgcgctcc tgatccacgg tcatctcgac gccgttcccg ccgacgcctc ggagtggtcg
    19441 gtgcacccgt tctccggcgc gatccaggac gactacgtct ggggtcgcgg cgcggtcgac
    19501 atgaaggaca tgtgcggcat ggcgctcgcg ctggcccgcc attacaagat caacggcatc
    19561 gtcccgccgc gcgacctggt gttcgcgttc ctcgccgacg aagaggcggg cggcaagtac
    19621 ggcgcgcagt ggctggtcga gaaccgtccc gagctgttcg agggtgtcac cgaggcgatc
    19681 agcgaggtcg gcggcttctc gatcacgctg aaggacaacg tccgcgcgta cctcatcgag
    19741 acggccgaaa agggcatccg ctggatgaag ctgcgggtgc gcggcaccgc cggtcacggc
    19801 tcgatgatcc accgcgacaa cgccgtcacc aagctctccg aggccgtcgc caggctcggc
    19861 aaccaccgct tcccgctggt gatgaccgac tccgtccgcg agttcctgga cggcgtcacc
    19921 gagatcaccg gctgggactt ccccgaggac gacatcgagg gttccgtcgc gaaactcggc
    19981 aacatctccc ggatgatcgg cgcgacgctg cgcgacacgg cgaacccgac gatgctcacc
    20041 gcgggctaca agtcgaacgt catcccgtcc gtcgcggagg cttcggtgga ctgccggatc
    20101 cttcccggca ggctcgaagc gttcaacgcc gaactggagg agatcctcgg cccggacatc
    20161 gagaaggagt ggatggagct gccgccggtc gagacgacct tcgacggcgc actggtcgac
    20221 gcgatgacca acgcggtcct cgccgaggac ccgggcgccc gcacgctccc gtacatgctt
    20281 tccggcggca ccgacgcgaa gtcgttccag tcgctcggga tccgcaactt cgggttcgcc
    20341 ccgctgaaac tgcccgcgga cctcgacttc tccgcgctgt tccacggggt cgacgagcgg
    20401 gtcccggtcg acgcgctgaa gttcggcgtg cgggtgctcg accgcttcct ccgctctgcc
    20461 tgatgcccgg tctgctggcc gccgacggca cacccctgca cttcgaccgc tggggtgatc
    20521 cgtcggcgcc ggtgaccgtg gtcctcctgc acgggtacgc cctcgacagg cgaagctggc
    20581 gtgccatcgc gccagtgctg gccgaggcgt ccccggagga accgctggcg gtagtggcct
    20641 acgaccagcg tggccacggt gaatccggtg aggtccgggc ctcgtcggcg accatgggga
    20701 aactcgccga cgatctggcc gaggtcctgg acaaggtggt ccccgacggc aaggtggtcc
    20761 tggtcggcca tgacatgggc gggctcgcga tcctgtcgct cgcccagcgc catccggacg
    20821 tcttcgcggc gcgggtggcg ggactcgggt tgctcgccat gtcggcgggc ggcgtcacgc
    20881 cggacgcgat ctggccgaac gcgctcggga aactcgggcg ggacctggag atcgtcttcg
    20941 ggacgaggct gatcggcctg gtgcgggagc atacgagcaa ggcggtgacc gccgggctgc
    21001 ggtggtggct gttcggcgac gacccggtgc ccgccgacgt cgagctgacc gtgcggatga
    21061 tccgcggcaa ctggccgcag acggtgtccg cgttccgccc cgcgctggac gcctacacgc
    21121 gggagtcggc gttgtcgcag gtcggggcgg tgccagtgac ggcgatcgtg ggggagcgcg
    21181 acaagctcgt gccgacggcg gacgtcgagg agctggcggg cgcggtggag aacggcacgg
    21241 ctgtggtgct gcccggcgtc gggcatgtcg tgcccctcga ggcggccccg caggtgattc
    21301 cccgccttct ggccctggcg aaccaggctc gccgacaatc ctgactttct tgacaaaatc
    21361 tgttttcggt gacaccgttt cgccatgttc tccgttgcgg tgatcgagga cgcggaagcg
    21421 gccgaagtgt cgctggatcc ggtccgggcc aggctgctcg ccgaactcgc cgaaccggcg
    21481 tcggccacga tgctggccgc gcgggtggac ctgccgagac agaaggtgaa ctaccacctt
    21541 cgcgcgctgg agaagcacgg actggtcgag ctcgtcgagg aacggcggaa gggcaacgtc
    21601 accgagcgca tgatgcgcgc gacggcgtcg tcgtacgtca tctcgccgac ggcgctctcg
    21661 gccgtgcagc ccgatcccgc ccagtcgccg gaccgcctgt ccgcacgctg gctgctcgcc
    21721 gtggcgggca ggctagtgcg cgacgtcggc ctcctgatca ccggagcgac caaggcgcgc
    21781 aaacgggtcg cgaccttcgc gatcgacggc gaggtgcggt tctcctccgc ggtggaccgg
    21841 gccgcgttcg ccgaagagct gaccgtcgcg atcacgaacc tggtgagcaa gtaccacgac
    21901 gaaggcgccg aacagggccg agatcaccgg atcgtcgtcg ccgtccaccc gagcgtccgc
    21961 accgagcccg aggagcgctg aatgggccac gaattcgaga tcaccgaccg cgtcgaggtc
    22021 gacgcgaccc cggaacaggt ctgggacgcc atcgcgaccg ggccggggat cacgtcctgg
    22081 ttcatggggc gcaacgaggt cgacggaggt gtcggtggca cggtgaagac cgctttcggc
    22141 ggcttcgaac ccacctcggc gatcacgtcg tgggacccgc tggaacggct cgtctacggc
    22201 acggaacccg cgccggacgg gcgcttcgtc gcctacgagt tcctcatcga gggccgctct
    22261 ggtggcagta ccgtgctgcg gaccgtgacg agcggcttcc tgcccggcga cgactgggaa
    22321 gacgagttcg aggcgatgac cgcgggcggc gagctgttcc tccgcaccct cgtcgagtac
    22381 ctcaaccggt tcgccggccg gaaagctgtg ccggtgacgg tgttcgggcc gatgatcgag
    22441 gactgggaca gtgcgtggct gacgctcggc cgggaactcg gcctcgccgg gcggccgcaa
    22501 gcgggggacc gggtccgcct gtcaaccgga ccgctgtcca ctgtggacgg cgaggtctat
    22561 ttcgcgaacg cccagacggt cgggatccgg acgccggacg cgctactgag gttcgtccgc
    22621 ggcttcaccg ggccgatatg cgcgatgcat cacctgttcg gcgatgtcgg ctccgcggaa
    22681 caggacgcgc tctgggccga gtggctcggc cgggtgttca agtgacgaaa gggctcgtcg
    22741 tcgcacctgg cgcgtcgtga gtggtaagtg tcgttctaac gcgccttatc actcacgacc
    22801 cgcgcgcgcg gacccgctcc tatgagcatc aagtgatgag gccgggcagg ggagtggcgg
    22861 tgcgcttgcg gcgcaaccac
//
