LOCUS       NZ_CP024972            21029 bp    DNA     circular CON 18-AUG-2024
DEFINITION  Amycolatopsis sp. TNS106 chromosome, complete genome.
ACCESSION   NZ_CP024972
VERSION     NZ_CP024972.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. TNS106
  ORGANISM  Amycolatopsis sp. TNS106
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Discovery of new natural product by Amycolatopsis speibonae genome
            mining
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8806031)
  AUTHORS   Liu,K. and Tao,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-NOV-2017) School of Life Sciences and Biotechnology,
            Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, Shanghai
            200030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP Assembly v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 116.0x
            Sequencing Technology             :: Illumina HiSeq 4000; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019330265.1-RS_2024_08_18
            Annotation Date                   :: 08/18/2024 03:49:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,321
            CDSs (total)                      :: 8,231
            Genes (coding)                    :: 8,179
            CDSs (with protein)               :: 8,179
            Genes (RNA)                       :: 90
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 75
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 52
            CDSs (without protein)            :: 52
            Pseudo Genes (ambiguous residues) :: 0 of 52
            Pseudo Genes (frameshifted)       :: 20 of 52
            Pseudo Genes (incomplete)         :: 35 of 52
            Pseudo Genes (internal stop)      :: 4 of 52
            Pseudo Genes (multiple problems)  :: 6 of 52
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:02:24
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 164798
            Orig. end                         :: 185827
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP024972.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21029
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="1"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21029
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21029
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11029](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11029)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(1205..2185)
                     /gene="add"
                     /locus_tag="CVV72_RS00820"
                     /old_locus_tag="CVV72_00805"
     CDS             complement(1205..2185)
                     /EC_number="3.5.4.4"
                     /GO_function="GO:0004000 - adenosine deaminase activity
                     [Evidence IEA]"
                     /GO_function="GO:0019239 - deaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0043101 - purine-containing compound
                     salvage [Evidence IEA]"
                     /codon_start=1
                     /gene="add"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630237.1"
                     /locus_tag="CVV72_RS00820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00805"
                     /product="adenosine deaminase"
                     /protein_id="WP_219150457.1"
                     /transl_table=11
                     /translation="MRDLSLLPKAHLHVHLESTIRPDTLRDLGEANGVAVPAEQPVFDG
                     FRAFGDYNGLLRSCLRRPEDFERVAREFCEDQVADGVRYAEVTFTAASHGERLGEPDMP
                     LASVLKGLSAGAAESGLHWRVLLDHSRRRPVERARLTLDLARRYAPDGVFAIGLAGEEK
                     YPLAPFAEICDEAEEAGLHLIHHAGEDAGPASIREALEAGHSERIGHGIRILEDVALVA
                     EVRERGIALEVCPSSNVTLGLVPSFEEHPLPRLIDAGLVVTLSTDVPSVTGTTLTDEFL
                     RTREAFAYDDLALAGLARASVDASFAPAELKRSIHQEIDAWLSRD"
     gene            2339..2557
                     /locus_tag="CVV72_RS00825"
                     /old_locus_tag="CVV72_00810"
     CDS             2339..2557
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335889.1"
                     /locus_tag="CVV72_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00810"
                     /product="antitoxin"
                     /protein_id="WP_016335889.1"
                     /transl_table=11
                     /translation="MPLLRKLTALAGTAGAVRAYVRKNPEKVSKVVNKAATFVDHKTKG
                     KYHSQIDGAVRKVDGMTGRPPRRPYEH"
     gene            complement(2564..4396)
                     /gene="recQ"
                     /locus_tag="CVV72_RS00830"
                     /old_locus_tag="CVV72_00815"
     CDS             complement(2564..4396)
                     /EC_number="5.6.2.4"
                     /GO_function="GO:0003678 - DNA helicase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /codon_start=1
                     /gene="recQ"
                     /gene_functions="other (smcogs) SMCOG1122: ATP-dependent
                     RNA helicase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335888.1"
                     /locus_tag="CVV72_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00815"
                     /product="DNA helicase RecQ"
                     /protein_id="WP_219150459.1"
                     /transl_table=11
                     /translation="MAAPDIGTSEALATLNRVFGYDDFRGDQHAIVEHVIAGGDALVLM
                     PTGGGKSLCYQIPALVRPGVGVVISPLIALMQDQVDALRNLGVRAGFLNSTQDYAERNR
                     VETAFVAGELDLLYLAPERLSVESTVRLLDRGKISLFAIDEAHCVSQWGHDFRPDYLML
                     SAVHERWPDVPRIALTATATKATHAEIASRLNLEDARHFVASFDRPNIQYRIVGKNSPQ
                     RQLLELLRTEHKGDAGIVYCLSRNSVEKTADFLVENGIPAVPYHAGLDARTRAKHQSRF
                     LREDGLIVVATIAFGMGIDKPDVRFVAHLDLPKSVEGYYQETGRAGRDGLPSTAWLAYG
                     LQDVVQQRKMIDMSEGSEAHKRQLSAHLNAMLALCETVECRRVQVLNYFGQRSEPCGNC
                     DTCLAPPETWDGTIPAQKILSTIVRLQNERRQKFGAGQIIDILLGKSTPKVTQHRHDSL
                     KVFGIGTELKEPEWRAVVRQLLAQGLAAVEGDYGSLVLTEGSAEVLNGERKVQLRREPE
                     RAAKAAARSSAKKAAAADMPAEAAPVFELLRSWRAAAAKEQGVPAYVIFHDATLRQIAT
                     KRPTTLQELGTVSGVGENKLAKYGEQILETLADA"
     gene            complement(4445..5266)
                     /locus_tag="CVV72_RS00835"
                     /old_locus_tag="CVV72_00820"
     CDS             complement(4445..5266)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630234.1"
                     /locus_tag="CVV72_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00820"
                     /product="SMI1/KNR4 family protein"
                     /protein_id="WP_219150461.1"
                     /transl_table=11
                     /translation="MRKGWGRAVVIAVASVVIVLGLVYAVTVRGGQDKGAQWYAAPPTT
                     PRMPSYSTAAPAPTTRPTLTVDSGCRLGQGPAALDPVPAATTRRVNTAWDRVERWLKAH
                     APTTAASLRPPATLARIAQAQRETGVPLPAELVAFLLRHDGVSGIGDSFALPPFHHLAS
                     TETIASQAKVMCEVLTSSGLDDNVGHWWHGRFLPVAVDGGGDGLFLDQRTGTGRLGDWN
                     HEGSVSFDHRPPTLTELLERTASALETGGPADGGYRPVVTGNRALDWEFPR"
     gene            complement(5276..5617)
                     /locus_tag="CVV72_RS00840"
                     /old_locus_tag="CVV72_00825"
     CDS             complement(5276..5617)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630233.1"
                     /locus_tag="CVV72_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00825"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_219150463.1"
                     /transl_table=11
                     /translation="MHAFDVLGDPVRRRILELLAGGEQSSGDVTAVVRAEFGISQPAVS
                     QHLRVLRENGFTTVRAEGSRRLYSVDPGPLKEIDGWLDQYRRFWTGPLDALATEIARGR
                     RERRKAAED"
     gene            5718..6230
                     /locus_tag="CVV72_RS00845"
                     /old_locus_tag="CVV72_00830"
     CDS             5718..6230
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630232.1"
                     /locus_tag="CVV72_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00830"
                     /product="DinB family protein"
                     /protein_id="WP_219150465.1"
                     /transl_table=11
                     /translation="MKLAEVVADGFGRVREVVHEAVEGLSADQLTASPAPGANTIAWLV
                     WHLTRVQDDHVAGLMGTEQIWTARDWMGRFSLPFPASDIGYGHRPEDVEAVRVGSADLL
                     TGYYDAVHEATTGWVAGLAEADLDRIVDEAWDPPVTLGVRLVSVLSDDLQHAGQAAYVR
                     GLVLRAT"
     gene            6288..6851
                     /locus_tag="CVV72_RS00850"
                     /old_locus_tag="CVV72_00835"
     CDS             6288..6851
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030027.1"
                     /locus_tag="CVV72_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00835"
                     /product="hypothetical protein"
                     /protein_id="WP_255632435.1"
                     /transl_table=11
                     /translation="MSTSTVRRPPMTLTPRWRKLVLVVHVVSSLGWLGITMVNAVLTFT
                     SVFTGDARRQQAAILMMDQIGGYLLLPVSMTALVSGIVLSLGTKWGLIRYKWVAIKLVL
                     TLIAAGLTLFSLLPGIRELAAATESTMDGVFVEAGRRVDGFYPIIVSTTMYVTMTVLSV
                     YKPGGKTPYGRRVTATRVRARQPV"
     gene            complement(6848..7717)
                     /locus_tag="CVV72_RS00855"
                     /old_locus_tag="CVV72_00840"
     CDS             complement(6848..7717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335884.1"
                     /locus_tag="CVV72_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00840"
                     /product="hypothetical protein"
                     /protein_id="WP_219150467.1"
                     /transl_table=11
                     /translation="MDFDEVADELYAGDPAEFVSVRNQRAKEAKAAGDPALGERIRALR
                     KPTLAASILNRRAGSPELAELAKLGDELRKAHSALAGADLRKLARRRQELVNRILRDER
                     SMSEPVSREVEATLEAVVADPEVAALALAGRLSSGADSTGDQWLTSGFNPQPKRKPAPE
                     REKPATVSHLDDRRKAKREAAEKAEQERIAKSREEAEREQKRVAEFNRLRREAAELAKA
                     CKQAETDVARAERRAEKATEKANDLRRRLADAELEEETANGETAAAQTVLDDLRAEAQR
                     IDEALEQF"
     gene            7998..8948
                     /locus_tag="CVV72_RS00860"
                     /old_locus_tag="CVV72_00845"
     CDS             7998..8948
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335883.1"
                     /locus_tag="CVV72_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00845"
                     /product="hypothetical protein"
                     /protein_id="WP_034324431.1"
                     /transl_table=11
                     /translation="MSVTERVPVSPQASFLGSGPYPEHRWRVVLWSVLAGFALTVLWSA
                     PFVDSVIGDSVANTLLGHDAKATPIGGVLAGTFFAFVSGLAGTFTACNIAAFGAVAPLV
                     GGRATGRPKFTDTLKPLGWIAAGMLTVSVVYGVIVALVGTRMPQFSTASSSGGLSPRNI
                     QSMIVYGVIGIVFIVLGLASVGIVRNPIAGLTRRFPPAPLVLMGALIGGFLIGRPFPLF
                     RMMFRSAAESHNVFYGAAAFALQSVGNILVMALLFLLLTHGTGGRLQRWMLAKPTRIAV
                     VTGAALLVAGTFTLLYWDLRVLGRTGVIWYPTIKW"
     gene            complement(8938..9564)
                     /locus_tag="CVV72_RS00865"
                     /old_locus_tag="CVV72_00850"
     CDS             complement(8938..9564)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030030.1"
                     /locus_tag="CVV72_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00850"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_219153745.1"
                     /transl_table=11
                     /translation="MTDVADRSGDETRQVDRFGQRRAQLARSALVTLSELGYARTSLRE
                     IAQNSEFSHGVLHYYFRDKAELITYCVKQYKAECVTRYDRIVETAETAEELRTAFGAAT
                     AATLRENARLHRLWYDLRNQSLFEKLFQADVLAIDETLELMIWRVVSRYAELVGKPAIF
                     SPSTTYALFDGLFQQGLLKHLAGREDAARCLQDSVEQVLARLLTT"
     misc_feature    9629..9640
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.36"
                     /tool="antismash"
     gene            complement(9656..9964)
                     /locus_tag="CVV72_RS00870"
                     /old_locus_tag="CVV72_00855"
     CDS             complement(9656..9964)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630226.1"
                     /locus_tag="CVV72_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00855"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_219150469.1"
                     /transl_table=11
                     /translation="MTTETLGNVEGRDIGSGVSIIRERTDVDGSGPRLHQHPYRETFVI
                     VRGRARFIIGDTEREGGAGDVLVVPAETPHKFAVIGPEVYEAVHIHESDHFITEWLE"
     gene            complement(10001..11029)
                     /locus_tag="CVV72_RS00875"
                     /old_locus_tag="CVV72_00860"
     CDS             complement(10001..11029)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335880.1"
                     /locus_tag="CVV72_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00860"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_255632436.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.4e-47, bitscore:
                     161.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTTTIVTELGLDPAVDRHAEFAAELRTGLARVEERLQEVLRSPG
                     HPELTEAATHLVRAGGKRLRPVMALAGAAFGDGRGDPISAAALVELIHVATLYHDDVMD
                     EAPMRHGVTSANSLWGNKKAVLIGDYVLACAARVGAGLGDYALRSQAQTFGRLVRGQFL
                     ETTGPFEVCGRHAPYEHHIQVMADKSASLIALAGRLGAQVSGADERTIETLGRYGELIG
                     VAFQISDDVLDISASTSDLGKSAGTDLREGIVTLPMLHALDDEGPGAVRLREIIGHGPV
                     PDPVIRQEALGLLRESAGVMRALAEAHGYAAKARDLALSLPDRPARALLVGLSAFVVDR
                     GE"
     gene            complement(11114..11557)
                     /locus_tag="CVV72_RS00880"
                     /old_locus_tag="CVV72_00865"
     CDS             complement(11114..11557)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005155056.1"
                     /locus_tag="CVV72_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00865"
                     /product="single-stranded DNA-binding protein"
                     /protein_id="WP_219150473.1"
                     /transl_table=11
                     /translation="MAGETVLTVIGNLTTDPELKFTPSGAAVANFTVASTPRVLDRASG
                     EWRDGDPLFLRCALWKQAAENLAESLTRGTRVIVQGRLKQRSFETKEGEKRTVVELDVD
                     EIGPSLRYATAKVNKAGRSSGGTPSDGAWERTPVPAGNPEPPF"
     gene            complement(11684..13138)
                     /locus_tag="CVV72_RS00885"
                     /old_locus_tag="CVV72_00870"
     CDS             complement(11684..13138)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (148-384). E-value:
                     6.9e-20. Score: 63.4. Matches aSDomain:
                     nrpspksdomains_CVV72_RS00885_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019: aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335878.1"
                     /locus_tag="CVV72_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00870"
                     /product="PLP-dependent aminotransferase family protein"
                     /protein_id="WP_219150475.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.4e-18, bitscore:
                     63.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFHISLDGHTDLAARIYRQLRDGIIDGRLRAGERLPPTRELARE
                     LDVSRNTVAVAYERLTAEGFLSGHVGRGTFVSADPVARTQRAAPAGGVRPAARWRSLPV
                     PLGEDRSAPAFDFRVGVPDPALFPLRTWRRLVSQALRPSLLTPSGYADPAGLEALRVAI
                     ARHVGAARSVRAGGEDLVVTQGAQQALDLIGRVLIEPGTRVAVEDPGYPPAERLFTAHG
                     ARVTKVPVDAEGLDVAALAKGTRLIYTTPSHQFPLGTPMSLSRRTALLAWAERNDAVIV
                     EDDYDSEFRFSDRPLEPLQSLDRDGRVLYVGSFSKTLLPLLRLGFLVAPASLRPALRQA
                     KQLMDWHGDLVTQSALASFIDEGLLARHVRKATREYSVRRERILAFARDELRDLLEVVP
                     SSAGLHLCALAGPHATDTVDGVVAEAARAGVAVENLATYGGTRGGLVIGYGLVGSDRVD
                     EGLARLGECVSAARLSRKDRSGHFSA"
     aSDomain        complement(11987..12694)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS00885_Aminotran_1_2.1"
                     /evalue="6.90E-20"
                     /label="CVV72_RS00885_Aminotran_1_2.1"
                     /locus_tag="CVV72_RS00885"
                     /protein_end="384"
                     /protein_start="148"
                     /score="63.4"
                     /tool="antismash"
                     /translation="GYADPAGLEALRVAIARHVGAARSVRAGGEDLVVTQGAQQALDLI
                     GRVLIEPGTRVAVEDPGYPPAERLFTAHGARVTKVPVDAEGLDVAALAKGTRLIYTTPS
                     HQFPLGTPMSLSRRTALLAWAERNDAVIVEDDYDSEFRFSDRPLEPLQSLDRDGRVLYV
                     GSFSKTLLPLLRLGFLVAPASLRPALRQAKQLMDWHGDLVTQSALASFIDEGLLARHVR
                     KATREYSVRRERIL"
     gene            13219..14439
                     /locus_tag="CVV72_RS00890"
                     /old_locus_tag="CVV72_00875"
     CDS             13219..14439
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630222.1"
                     /locus_tag="CVV72_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00875"
                     /product="MFS transporter"
                     /protein_id="WP_219150477.1"
                     /transl_table=11
                     /translation="MKRLISAQLISSVGDGAYYVSSALYFTLVVGLSPAQVGLGLTVGW
                     AVGSVAGIALGQVADRRGPKGTAVLLALGTAASVTAFLFVGSVFTFVIAACVYACFQCG
                     LGAARQALLAGLIDPAERTTFRARLQALSNAGIAIGAALGGIALALGTREAFLTVFVLD
                     ALAFVAAALVLRKVPTVAPLPPREGEPSVAVLRDRPYALLALLNMVMVLYMPLFSLVLP
                     LWISTRTAAPSWLVSAMLVLNTASVVVFQVRVTRGVTGLRSAAGYARYAGLLLFFSCLV
                     FSFSAMGESAWAAALILLLGATLQVVGEMAQAAGSWEIAFGLAPEGKQGQYQGFFGAGT
                     AIARMLGPVLLTGLILVGGTAGWMVLGGLFLVAGLLTGPAVRWAERKSRPGAEVSPRVL
                     AGSARRG"
     gene            complement(14399..14791)
                     /locus_tag="CVV72_RS00895"
                     /old_locus_tag="CVV72_00880"
     CDS             complement(14399..14791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030035.1"
                     /locus_tag="CVV72_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00880"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_219150479.1"
                     /transl_table=11
                     /translation="MTDKYLAYGRLIRDGKILFIRRRPGSFLGGRWELPGGTVEPGERP
                     TETVVREFAEETGLTVRVTGERGTHSWDDVAGRPMRIHAAVYALSEETAGEVVLDPEEH
                     DAFAWHTREEAAELNLAVHFRRALED"
     gene            14870..16027
                     /locus_tag="CVV72_RS00900"
                     /old_locus_tag="CVV72_00885"
     CDS             14870..16027
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (96-222). E-value:
                     4.4e-13. Score: 41.3. Matches aSDomain:
                     nrpspksdomains_CVV72_RS00900_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335875.1"
                     /locus_tag="CVV72_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00885"
                     /product="epoxide hydrolase family protein"
                     /protein_id="WP_219150481.1"
                     /sec_met_domain="PF00561 (E-value: 3.1e-08, bitscore: 32.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENTEIRPFRLDIPQEQLDELHAKLDSARWPAPLPGDGWDTGVPV
                     AWLRGLAEYWRDGYDWRAAEREINRHPQFTTVIDGQRIHFLHVRSPEAGATPLILTHGW
                     PGSVVEFLDVIGPLTDPKAYGGDPADAFHLVIPSLPGFGFSGPVSDSGWTMPRIGRAWA
                     ELMRRLGYERYGVQGGDLGASVSPEVARSAPDKVIGVHVNGGLTPMPPMSLSEEELASL
                     TDVERDRVKRIGAFMQEEFGYIAIQSTRPQTVGYGLVDSPVAQLAWIMDKFREWTHPRP
                     TLPEEIIDKDRLLTNVMFTWLTGTAASSAYVGYAQAETWGAVEKNSGVPTAALVFAHDV
                     GIRRYSEDAHTIVRWTDVDRGGHFAALEEPEILVSDVREFFRSLK"
     aSDomain        15158..15535
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CVV72_RS00900_Abhydrolase_1.1"
                     /evalue="4.40E-13"
                     /label="CVV72_RS00900_Abhydrolase_1.1"
                     /locus_tag="CVV72_RS00900"
                     /protein_end="222"
                     /protein_start="96"
                     /score="41.3"
                     /tool="antismash"
                     /translation="PLILTHGWPGSVVEFLDVIGPLTDPKAYGGDPADAFHLVIPSLPG
                     FGFSGPVSDSGWTMPRIGRAWAELMRRLGYERYGVQGGDLGASVSPEVARSAPDKVIGV
                     HVNGGLTPMPPMSLSEEELASL"
     gene            complement(16020..17066)
                     /locus_tag="CVV72_RS00905"
                     /old_locus_tag="CVV72_00890"
     CDS             complement(16020..17066)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630219.1"
                     /locus_tag="CVV72_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00890"
                     /product="winged helix DNA-binding domain-containing
                     protein"
                     /protein_id="WP_219150483.1"
                     /transl_table=11
                     /translation="MTLSDDDLRAVRAHAQLLTVPATDVLTVVGSVAAVQAQSTPAARL
                     AIRARGRGLTAPDVDTSHAVTRTWLMRKTLHLVPTADLRWLNRLFGPRNAQAGQGRRRQ
                     LGLTDELCELALGKIQDLLPGKALTRQGILDGLAAEGITLDAKSQAPAHLLAYAANRGL
                     VCRGHDAGTEPTYVLLDEWVAESRTPDEPDTELARRYLTAYGVATAEDFGAWSGLPLSL
                     CRKAFTALDPVPVGKRFALSETELSAPPCPPRLLGAFDTYLLGYRDRGLLVDPAEAKRV
                     NSGGGMIAPTVLIDGRIAGTWHTKRTAKLTKVVVEPFATLPRSVIAELEPEVDEYGRFL
                     GETAVLVI"
     gene            17173..17544
                     /locus_tag="CVV72_RS00910"
                     /old_locus_tag="CVV72_00895"
     CDS             17173..17544
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335871.1"
                     /locus_tag="CVV72_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00895"
                     /product="DUF6153 family protein"
                     /protein_id="WP_219150485.1"
                     /transl_table=11
                     /translation="MTQSSYPAALRWLLLCVVALGLVGMHHVVADSGHDAGHSAVAMAD
                     PCCADAPSHDDGGHNGLHLCLAVLAAAVLLIVSWLLVRTGRTVATWKSRRVGGSASGRD
                     PPRWRPVPERLSLLCVLRV"
     gene            17592..18179
                     /locus_tag="CVV72_RS00915"
                     /old_locus_tag="CVV72_00900"
     CDS             17592..18179
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335870.1"
                     /locus_tag="CVV72_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00900"
                     /product="DUF305 domain-containing protein"
                     /protein_id="WP_219150487.1"
                     /transl_table=11
                     /translation="MTSRKLAGAALAALASFAVLTGCASSDTASTGHAASTVKAPDPQQ
                     AGHNQADVTFAQGMIPHHEQALKMAKLVDGRTRNAKVVDLATRIQKAQDPEIQQLNGLL
                     KGWGVAPSGEHSGHGSASGMMTEDDLEKLGKAKDAAFDKQWLEMMVKHHEGALEMAKTA
                     LQQGSNAEVKALAQKVIDGQQAEITEMRALLG"
     gene            18263..18547
                     /locus_tag="CVV72_RS00920"
                     /old_locus_tag="CVV72_00905"
     CDS             18263..18547
                     /EC_number="2.1.1.222"
                     /EC_number="2.1.1.64"
                     /GO_function="GO:0008425 -
                     2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0061542 - 3-demethylubiquinol-n
                     3-O-methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:0102208 - 2-polyprenyl-6-hydroxyphenol
                     methylase activity [Evidence IEA]"
                     /GO_process="GO:0006744 - ubiquinone biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="CVV72_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00905"
                     /product="bifunctional 2-polyprenyl-6-hydroxyphenol
                     methylase/3-demethylubiquinol 3-O-methyltransferase UbiG"
                     /protein_id="WP_255632437.1"
                     /transl_table=11
                     /translation="MLDVGCGAGLAVSELSRLGLRAVGVDLSAEMAEEARQVSVDGVIG
                     YFAGESFLRGLADIAVRVGAVSVAEGRSGWRIGSVRWRCRGSWLPGGVR"
     gene            18689..19924
                     /locus_tag="CVV72_RS00925"
                     /old_locus_tag="CVV72_00910"
     CDS             18689..19924
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020629864.1"
                     /locus_tag="CVV72_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00910"
                     /product="HNH endonuclease signature motif containing
                     protein"
                     /protein_id="WP_255632438.1"
                     /transl_table=11
                     /translation="MDTRNATVALLKEITSPDALREVNAALDSLEDNDAIDAAVAASEG
                     IARLEAVHFRALAQLTRHRDDASSVVQEVAFALSIVDGHAAGLVSTAAALTTRLPRTLG
                     LLDRGQVGGYGAMKVATATAWLSDEDARAVDDVLEDRLPGRNSEQIRKAANHAAMMADR
                     DGAARRAERHREGRRLSIRQGETGVASIEVEDGPVEKVAAAYTRIDREARALKTGGETR
                     TLDQLRADIALDLMLGGQGGKAERSEVFLYMDLDTYLGVNDDPAELAGHGHIPATLARR
                     IASGPDTVLRRIITDPLSGQVLDLGRDRYRPTAGLGEFVRVRDRECRRPGCHRPAQACD
                     LDHSVPWQHGGHTADTELVDLCRRDHRLKDEPGWIYRLAEDGTLTITTPTGHSYDSTPP
                     PLHEPRTQEPPF"
     gene            20574..20969
                     /locus_tag="CVV72_RS00930"
                     /old_locus_tag="CVV72_00915"
     CDS             20574..20969
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333745.1"
                     /locus_tag="CVV72_RS00930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CVV72_00915"
                     /product="hypothetical protein"
                     /protein_id="WP_219150489.1"
                     /transl_table=11
                     /translation="MMLALAFVGAGSAAADQSKSISGASPDGGASFSGTLTWTGRGGFK
                     ADVTLKDAKCDGNPVYFYFIINKGWTSEWQGKRRDNNEGCGKTITWKGIAGSDSNGIYG
                     PTLRVCTDIRPGVDSCREYGYDNPYFP"
     misc_feature    complement(20581..20596)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.42"
                     /tool="antismash"
ORIGIN
        1 ggcgtcgtcc gacaacgtcg gcgtcaccgg gtaccgcgtc ctgcggaacg ggcaaaccgt
       61 tgccacgacg gtgaatccgc ccgcgacggt gaccggtctc gccgcgtcga cggcctactc
      121 gttcacggtg gtcgcctacg acgcggcggg gaacacgtcc gcgccgagtg ccgtcgtctc
      181 cgccaccacc ccggcgtgcg gtaccgggac accggtgtcc atcaacggaa agctccacgt
      241 ctgcggtgtc aaactgtgca accagtacgg caagcccatc cagctgcggg ggatgagcac
      301 ccacgggatc cagtggtaca gccaatgcgt gaagaccgcc tcgctggacg cgctggccaa
      361 cgactggaag gccgacatcc tgcgcgtcgc catgtacatc caggacgacg gctacgagag
      421 caacccgcgc aagttcaccg acatgatgca caactacatc gaagaggcga cgaaacgcgg
      481 gatgtacgtc ctcgtcgact ggcatcagct cgaccctggc gacccgaacg cgaacaccca
      541 cctcgcgaag accttcttca ccgagatcgc ccagcggcac aaggacaagg tcaacatcat
      601 ctacgacgtc gccaacgaac cgaacggcgt cagctgggcg gacgtgaagc ggtacgccga
      661 agaggtcatc ccggtgatcc gcgcccagga cccggacagc gtcgtcttcc tcgggacgca
      721 cggctggtcg accttcggaa tctccgacca gcgcgacgag accgacatcc tgaacaaccc
      781 ggtcaacgcc accaacatca tgtacacgtt ccacttctac gcggcgtcgc accaggacga
      841 gcactacgac gccttggcgc ggacggccga caagctcccg gtgttcgtca cggaattcgg
      901 cacccagacc tacacgggtg acggcgggaa cgacttcacc tactcgcaga agtacctgga
      961 tctgctggcc gccaagaaga tcggctggac gaactggaac ttctccgacg acttccgctc
     1021 cggtgccgtg ttcaagaccg gaacctgcgc cgggagctcc ttcaccggca cttcgatgct
     1081 gaaacccgcc ggtgtctggg tgcgggaccg catccgcacg ccggacgact tcccgaccgg
     1141 ctgattcccc gcatttcgtc ctctggatgc ggtacttgca cgcgcaagga ccgcatccag
     1201 aggactaatc gcgggagagc caggcgtcga tctcttggtg gatcgaacgc ttgagttcgg
     1261 cgggcgcgaa ggacgcgtcg acggacgccc gggcgagacc cgcgagcgcg agatcgtcgt
     1321 aggcgaacgc ctcacgagtg cgcaggaact cgtcggtcag cgtcgtcccg gtcaccgaag
     1381 ggacgtcggt gctgagcgtg accacgagcc cggcgtcgat cagccggggg agcgggtgct
     1441 cctcgaacga gggaacgagc ccgagcgtca cgttcgacga cgggcagacc tccagcgcga
     1501 taccgcgttc ccgcacctcg gcgaccagcg cgacgtcctc caggatccgg atgccgtggc
     1561 cgatccgttc gctgtgcccg gcctccagtg cctcgcggat gctggcaggt ccggcgtcct
     1621 ccccggcgtg gtggatcagg tgcagccccg cctcctcggc ctcgtcgcag atctcggcga
     1681 acggcgcgag cgggtacttc tcctccccgg ccagcccgat cgcgaacacc ccgtccggcg
     1741 cgtaccggcg tgccaggtcg agggtgaggc gggcacgttc gaccggacgg cggcgcgagt
     1801 gatccagcag aacccgccag tggagcccgg attcggccgc ccccgccgag agtcctttga
     1861 ggaccgacgc cagtggcatg tccggttcgc ccagtcgttc gccgtgcgaa gccgccgtga
     1921 aggtgacctc ggcgtagcgg acgccgtccg cgacctggtc ctcacagaac tcccgcgcca
     1981 cccgttcgaa gtcctccggc ctccgcaggc aggagcggag caggccgttg tagtcaccga
     2041 acgcgcggaa gccgtcgaac acgggttgtt ccgcgggtac ggcgacgccg ttcgcctcgc
     2101 cgaggtcacg gagcgtgtcc ggcctgatgg tgctttcgag gtggacgtgc agatgcgcct
     2161 tgggcagcag cgaaagatcc cgcatgagca ccaagttagt ggccccggcc ctcgtcccgc
     2221 gcccggtttt ccggcggccg gatatccgaa atgagtgatt cggctcgcgg cggggaaccc
     2281 agggggcacc accggtcgtt gagcaggaca ccagacgacc ccgaggaaag ggaccacagt
     2341 gcctctactg cggaagttga ccgccctggc cggcaccgcc ggggccgtgc gcgcctacgt
     2401 gcggaagaac cccgagaagg tctccaaggt cgtgaacaag gccgcgacct tcgtcgatca
     2461 caagaccaag ggcaagtacc acagccagat cgacggcgcg gtacgcaagg tcgacgggat
     2521 gaccgggcgg ccgccgcgcc ggccttacga gcactagggc gccctaggcg tccgctagcg
     2581 tctcgaggat ctgctcgccg tacttcgcga gcttgttctc gccgacgccg ctgacggtac
     2641 ccagctcctg cagcgtggtg ggccgtttgg tggcgatctg gcgcagggtc gcgtcgtgga
     2701 agatcacgta cgcgggcaca ccctgttcct tcgccgccgc ggcccgccac gagcgcagca
     2761 gctcgaacac cggcgccgcc tcggcgggca tgtcggcggc cgcggccttc ttcgcgctgg
     2821 accgggccgc ggccttcgcc gcccgctccg gctcgcgccg cagctggacc ttccgctccc
     2881 cgttgagcac ctcggcgctg ccctcggtca gcacgagcga gccgtagtcg ccctcgaccg
     2941 cggcgagccc ctgcgccagc agctgccgca ccacggcccg ccattcgggc tccttcagct
     3001 ccgtgccgat cccgaagacc ttcagggaat cgtgccggtg ctgtgtcacc ttcggcgtcg
     3061 acttgccgag cagaatgtcg atgatctgcc cagcgccgaa cttctggcgg cgctcgttct
     3121 gcagccggac gatggtcgaa aggatcttct gcgccgggat cgtgccgtcc caggtctccg
     3181 gcggcgccag gcaggtgtcg cagttgccgc agggctcgct ccgctgcccg aagtagttca
     3241 gcacctgcac acgacggcat tcgaccgtct cgcacagtgc cagcatcgcg ttgaggtggg
     3301 cgctcagctg ccgcttgtgc gcctcggacc cctccgacat gtcgatcatc ttgcgctgct
     3361 ggacgacgtc ttggaggccg tacgccagcc acgccgtcga cggcagcccg tcacggcccg
     3421 cgcggccggt ctcctggtag tagccctcga cggatttcgg caggtccaga tgcgcgacga
     3481 accgtacgtc gggtttgtcg atgcccatgc cgaacgcgat cgtcgcgacg acgatcagcc
     3541 cgtcctcgcg caggaaccgc gactggtgct tcgcgcgggt ccgtgcgtcc agcccggcgt
     3601 gatacggcac cgccgggatc ccgttctcga ccaggaaatc cgcggtcttc tcgaccgagt
     3661 ttcgcgacag gcagtagacg atgcccgcgt cgcccttgtg ctcggtgcgc agcagctcca
     3721 gcaactgccg ctgcggcgag ttcttgccga cgatccggta ctggatgttc ggccggtcga
     3781 agctggcgac gaaatgccgg gcgtcctcca ggttgagccg ggacgcgatc tcggcgtgtg
     3841 tcgccttggt ggcggtggcg gtgagcgcga tcctcggcac gtccggccag cgctcgtgca
     3901 ccgcggacag catcaggtag tcgggccgga agtcgtgacc ccactgggag acgcagtgcg
     3961 cctcgtcgat cgcgaacagc gagatcttgc ctcggtccag cagccgcacg gtggattcga
     4021 ccgagagccg ttcgggagcc aggtacagca ggtccagctc gccggcgacg aacgcggtct
     4081 cgaccctgtt ccgctcggcg tagtcctgtg tcgagttgag gaaacccgcg cgcacgccga
     4141 ggttccgcag cgcgtcgacc tggtcctgca tcagcgcgat caagggggag atcaccacgc
     4201 cgacgcccgg ccgcaccagc gccgggatct ggtaacacag cgacttgcca ccgccggtgg
     4261 gcatgaggac gagcgcgtca ccgcctgcga tgacgtgttc gacgatggcg tgctggtcgc
     4321 cgcggaagtc gtcgtagccg aagacgcggt tcagcgtcgc gagggcttcc gaggtaccga
     4381 tgtcgggggc tgccacccgg acgattctag gggcggggtc cgacagtcga cgcgcccgag
     4441 cacctcagcg cgggaattcc cagtccagcg cccggtttcc ggtgacgacc ggccggtaac
     4501 cgccgtcggc gggcccgccg gtctcgagcg cggacgcggt ccgctccagc agctcggtca
     4561 gggtcggggg ccggtggtcg aagctcaccg aaccctcgtg gttccagtcg ccgagccgac
     4621 cggtgccggt gcgctggtcg aggaacagcc cgtcgccacc gccgtcgacg gcgacgggca
     4681 ggaaccgccc gtgccaccag tggccgacgt tgtcgtccag cccgctcgac gtcagcacct
     4741 cgcacatgac cttcgcctgg ctcgcgatgg tttcagtgga ggccaggtgg tggaacgggg
     4801 gcagggcgaa gctgtcgccg atacccgaaa caccgtcgtg cctcagaagg aaggcgacga
     4861 gttcggcggg aagggggacg ccggtctccc gttgcgcctg ggcgatccgc gcgagcgtcg
     4921 cgggtgggcg gaggctcgcc gccgtcgtcg gcgcgtgggc cttgagccat cgctcgacgc
     4981 ggtcccaggc ggtgttcacc cggcgggtgg tcgccgcggg gacgggatcg agtgcggccg
     5041 ggccctgtcc cagccggcag ccgctgtcga cggtgagcgt cggccgggtc gtgggcgcgg
     5101 gtgcggcggt cgagtaggac ggcatgcgcg gtgtcgtcgg cggggccgcg taccactgcg
     5161 ctcccttgtc ctgcccgcca cgcaccgtca ccgcgtaaac gagccccagc acgatgacga
     5221 cactcgcgac ggcgatcacc actgcgcgtc cccagccttt gcgcatgggg agagactagt
     5281 cttcggcggc cttacggcgt tcgcggcggc cgcgcgcgat ctcggtggcc agcgcgtcga
     5341 gcgggccggt ccagaaccgc cggtactggt ccagccagcc gtcgatctcc ttcagcggac
     5401 ccggatcgac cgagtacaac cgtcgcgagc cctcggcacg gacggtggtg aacccgttct
     5461 cgcgcaggac gcgcaggtgc tgggagaccg cgggctgcga gatgccgaac tcggcgcgga
     5521 ccaccgcggt cacgtcgccg gaactctgtt ccccgcccgc cagcagttcc aggatccggc
     5581 ggcgcaccgg atccccgagg acgtcgaacg cgtgcatccg gcaactatca cggcctgggc
     5641 ttatataagt caagcgtgta aggccggggt cacctcgcgg tggcatcgtg gggcgggaga
     5701 cgccggaagg ggaatcgatg aaactggccg aagtggtggc cgacgggttc ggtcgcgtcc
     5761 gagaggtcgt gcacgaagcc gtcgaggggc tgagcgccga tcagctgacc gcgagcccgg
     5821 cgccgggcgc gaacacgatc gcctggctgg tctggcatct gacccgggtg caggacgatc
     5881 acgtcgccgg cctgatgggc accgagcaga tttggaccgc gcgggactgg atgggccgct
     5941 tctcgctgcc ctttccggcg tcggacatcg gctacggaca tcgtcccgaa gacgtcgagg
     6001 cggtccgtgt cggctccgcc gacctgctga cgggctacta cgacgcggtg cacgaagcga
     6061 cgacgggttg ggtcgccgga ctggccgaag ccgacctcga ccgtatcgtc gacgaggcgt
     6121 gggatccgcc cgtcaccctc ggggttcgcc tggtcagcgt gctctccgac gacctccagc
     6181 acgccgggca ggcggcgtac gtccgggggc tcgtactccg cgctacgtag gcgaggtgcc
     6241 gctccacgac ggacgacggg aacaccgccc gcggaaacac tggtcgcatg agtacttcca
     6301 cagtgcggcg accgccgatg acgctcaccc cgcggtggcg gaaactcgtc ctcgtcgtcc
     6361 atgtcgtttc gtcactcggc tggctcggga tcaccatggt gaacgcggtc ctgaccttca
     6421 cctccgtgtt caccggcgac gcccgccgcc agcaagcggc catcctgatg atggaccaga
     6481 tcggcggcta tctcctgctg ccggtcagca tgaccgcact ggtcagcggg atcgtgctca
     6541 gcctcggcac gaaatggggc ctgatccggt acaagtgggt ggcgatcaaa ctggtcctga
     6601 ccctgatcgc cgccgggctg acgctgttct cgctgcttcc gggcatccgg gaactggcgg
     6661 ccgcgaccga gtccactatg gacggtgtat tcgtggaggc cgggcggcgc gtggacgggt
     6721 tctacccgat catcgtgtcc accacgatgt acgtgaccat gaccgtgctg tcggtgtaca
     6781 agccgggcgg aaagaccccg tacggacgcc gggtgaccgc cacccgggtc cgtgcccggc
     6841 agccggttta gaactgttcc agagcttcgt cgatccgctg ggcttcggcg cgcagatcgt
     6901 ccaagacggt ctgcgcggcc gcggtctcac cgttcgccgt ctcttcctcg agttcggcgt
     6961 cggcgagccg ccgccggagg tcgttcgcct tctccgtggc cttctccgcc cggcgttcgg
     7021 cgcgggcgac gtcggtctcg gcctgtttgc aggccttcgc gagctcggcg gcctcgcgcc
     7081 ggagccggtt gaactccgcc acccgcttct gttcgcgttc ggcctcttcg cgggacttcg
     7141 cgatccgctc ctgctcggcc ttctcggcgg cttcccgctt cgccttccgc cgatcgtcca
     7201 aatgcgacac ggtggcgggc ttctcgcgct ccggcgcggg tttccgcttc ggctgtgggt
     7261 tgaacccact ggtcagccat tggtcgcccg tgctgtccgc cccgctgctc agccgcccgg
     7321 ccagtgcgag cgccgcgacc tcgggatcgg cgacgacggc ttcgagggtg gcctcgactt
     7381 cgcgggagac cggctcgctc atcgaacgtt cgtcccgcag gatccggttc accagctcct
     7441 gccgccgccg ggcgagtttg cgcaagtcgg cgccggccag cgccgaatgc gccttgcgca
     7501 gttcgtcgcc gagcttggcc agctccgcca gctcgggtga gcccgcccgg cggttgagga
     7561 tcgaggccgc gagcgtgggc ttccgcaggg cgcggatacg ctcgcccaaa gcggggtccc
     7621 ccgcggcctt ggcctctttc gcccgttggt tgcgcaccga gacgaactcg gccggatcgc
     7681 cggcgtagag ctcgtccgcg acttcgtcga agtccatcgc cctccgcagg gtcgtggccg
     7741 gtcaaggcct gatcgggtgg ccgtgctgcc gtacgcgtcc gacgatgatc ccacgagacc
     7801 ccggagcttt cacctttacg gactcatccg gccacctagc ggatcacgtc ctccggtgac
     7861 acccgccgga ccggtgaatc cgggttaccc ggagccggtc ggaccaaggg cagatcggca
     7921 ctttggaggt ggtttcctcc cgatggcgga acaacgatgg tgatcagggg gaagccaacg
     7981 gccgctggag gcaccgaatg tccgtcaccg aacgcgttcc cgtttcaccg caggcgagtt
     8041 tcctcggttc cggaccgtat ccggaacacc gatggcgcgt ggtgctctgg tccgtcctgg
     8101 cgggcttcgc gctgaccgtg ctctggtcgg cgccctttgt ggacagtgtg atcggtgaca
     8161 gtgtcgccaa cacccttctg ggacacgacg ccaaggcgac cccgatcggc ggagtgctgg
     8221 ccggaacgtt cttcgcgttc gtctcggggc tggccggaac gttcaccgcc tgcaacatcg
     8281 ccgctttcgg tgccgtggcc ccgcttgtcg gcggacgagc caccgggcgg ccgaagttca
     8341 cggacacgct gaagccactg ggctggatcg cggcgggaat gctgacggtt tcggtggtgt
     8401 acggtgtcat cgtcgctctc gtcggcacca ggatgccgca gttctcgacg gcctcgtcgt
     8461 caggtgggct cagcccgcgg aacatccagt cgatgatcgt ctacggcgtg atcgggatcg
     8521 tgttcatcgt gctgggcctg gcttccgtcg gcatcgtccg caacccgatc gccggcctca
     8581 cgcgccggtt cccgcccgcg ccgctcgtgc tgatgggcgc gctcatcggc ggtttcctga
     8641 tcggcaggcc gttcccgctg ttccggatga tgttccgcag cgcggccgag agccacaacg
     8701 tgttctacgg cgccgccgcg ttcgccctgc agtcggtcgg caacatcctg gtgatggcgc
     8761 tgttgttcct tctgctcacg cacggcacgg gcgggcggct gcagcgatgg atgctcgcga
     8821 aacccaccag gatcgccgtg gtgaccggtg ccgcgttgct ggtcgccggc acgttcacgc
     8881 tgctgtactg ggatctgcgc gtgctgggcc ggacgggcgt catctggtac ccgacgatca
     8941 agtggtgaga agccgggcca gtacctgctc caccgaatcc tgaaggcatc tcgccgcgtc
     9001 ctcccggccg gcgagatgct tcagcaggcc ctgctggaac aggccgtcga agagcgcata
     9061 cgtcgtcgac ggggagaaaa tcgccggttt gcccacgagt tccgcgtacc gggagacgac
     9121 ccgccagatc atcagttcga gtgtctcgtc gatggcgaga acgtcggcct ggaacagctt
     9181 ctcgaacagg ctctggttgc gcaggtcgta ccagagccgg tgcagccgcg cgttttcccg
     9241 cagcgtggcc gccgtcgcgg ctccgaaggc cgttctcagc tcttcggccg tttccgccgt
     9301 ttcgactatc cggtcgtacc gggtgacgca ttcggccttg tactgcttga cgcagtaggt
     9361 gatcagctcg gccttgtccc ggaagtagta gtgcaggacc ccgtgggaga actcggagtt
     9421 ctgcgctatc tcccgcaggc tcgtgcgcgc gtagcccagc tcggacaacg tgaccagcgc
     9481 cgacctcgcc agctgcgcgc gccgttggcc gaatctgtcc acctggcgcg tttcgtcacc
     9541 gctgcggtcc gccacgtcgg tcacagttcc cggttcccgt cgcctcgggt gcccgccgtc
     9601 cacgagcacg tcgtgggatt ctagccggga aagggttttc ttgcgcccga cagaattatt
     9661 cgagccattc ggtgatgaaa tggtcgcttt cgtggatgtg gacggcctcg tagacttccg
     9721 gcccgatcac ggcgaacttg tgcggggtct ccgcgggcac gacgaggacg tcgcccgcgc
     9781 ctccttcgcg ttcggtgtcc ccgatgatga acctggcccg gccgcggacg atgacgaacg
     9841 tctcccgata cggatgctgg tgcagcctcg gcccggaacc gtcgacgtcg gtccgctcgc
     9901 ggatgatcga gactccggag ccgatgtcgc gcccctcgac gtttcccagg gtttcggtgg
     9961 tcattccgcc actctagccc tggtcacgga cgccgtgggg ctactcgccg cggtcgacca
    10021 cgaacgccga aaggccgacg agcaacgccc tggcgggccg gtcgggaagg ctcagcgcga
    10081 ggtctctcgc cttggcggcg tatccgtggg cctcggcgag tgcgcgcatg acaccggcgg
    10141 attcgcgcag gagcccgagc gcctcttggc ggatcaccgg atcgggaacc ggtccgtggc
    10201 cgatgatctc gcgcaggcgg acggcgccgg gtccctcgtc gtcgagcgcg tggagcatcg
    10261 gcagggtgac gatgccttca cggagatccg tgcccgcgga cttgcccagg tcgctggtgg
    10321 acgcggagat gtcgaggacg tcgtcggaga tctggaacgc cactccgatc agctcgccgt
    10381 accggcccaa cgtttcgatg gtccgctcat ccgcacccga cacctgcgcg ccgagcctgc
    10441 ccgccagcgc gatcagcgac gcggatttgt cggccatcac ctggatgtga tgctcgtacg
    10501 gcgcgtgacg gccacaaacc tcgaagggcc cggtcgtctc gaggaactga ccgcgcacga
    10561 gcctgccgaa cgtctgagcc tgtgaccgca acgcgtagtc gccgagcccg gcaccgacgc
    10621 gtgccgcgca ggcgagcacg tagtctccga tcagcaccgc tttcttgttg ccccacaagg
    10681 agttcgcact ggtgaccccg tgccgcatcg gtgcctcgtc catgacgtcg tcgtgataga
    10741 gcgtcgcgac gtggatcaac tcgacgagtg cggccgccga gatcggatcg cctcgtccgt
    10801 cgccgaaagc cgctcccgcc aacgccatca ccggacgaag cctcttcccg cccgcgcgga
    10861 cgagatgggt ggcggcttcg gtgagttccg gatgaccggg gctgcgcaac acctcctgaa
    10921 gtctctcttc gacccgggcg agcccggtgc ggagttcggc ggcgaactcc gcgtgccgat
    10981 cgacggccgg gtccaggccg agttccgtaa cgatcgtggt cgtgttcacg acctccagca
    11041 tccgagccgg aggttcgcga ccgcatggcg cccgggaggg agatcgctcc ctcccgagag
    11101 ggaaaccgcc cggtcagaag ggcggctccg ggtttccggc gggcaccggc gttcgctccc
    11161 aggccccgtc cgacggcgtg ccgcccgaac tccggcccgc tttgttcacc ttcgccgtgg
    11221 cataccgcag cgacgggccg atctcgtcga cgtcgagctc caccaccgtg cgtttctcgc
    11281 cttccttggt ttcgaacgat cgctgtttca gcctgccctg cacgatgacc ctcgtccctc
    11341 tggtgaggga ttcggccagg ttttccgcgg cctgcttcca cagcgcgcag cgcaggaaca
    11401 gcgggtctcc gtcgcgccat tccccgctcg cgcggtccag gacgcgtggt gtcgacgcga
    11461 ccgtgaagtt cgcgaccgcc gctccggacg gggtgaactt cagctccggg tcggtcgtca
    11521 ggttgccgat caccgtgagc accgtttctc cggccatggg attttcctcc tcgtggtccg
    11581 cgcgcgggac ccggccgggc ccgctgtcgc cggtgaagag gagaccaccg gggtacgaca
    11641 gtttccggcg tcccgcggcc gccggatgtc acgaaagggt cgttcaagcc gaaaagtggc
    11701 ctgaacggtc ctttcgtgac agccgagcgg ccgagacgca ttccccgagc cgcgcgagcc
    11761 cttcgtcgac gcggtcggaa ccgaccagtc cgtagccgat caccagcccg ccgcgtgtgc
    11821 ccccataggt ggccaggttt tcgacggcca cgcccgctct ggccgcttcc gcgacgacac
    11881 cgtccacagt gtccgtcgcg tgtggaccgg ccaaggcgca caggtgcagc ccggcgctcg
    11941 acgggacgac ttccagcaga tcgcgcagtt cgtcgcgggc gaacgccagg atccgctccc
    12001 gtcgcaccga atactcccgc gtcgctttgc gcacgtgacg ggcgagaaga ccctcgtcga
    12061 tgaagctcgc caacgccgat tgcgtgacga gatcgccgtg ccagtccatg agctgcttcg
    12121 cctgccgcaa cgccgggcgc agcgaagcgg gcgccaccag gaaaccgaga cgcagcaagg
    12181 gcagcagagt cttcgagaac gatccgacgt acagcaccct gccgtcacgg tccaggcttt
    12241 ggagcggttc gagcggccgg tccgagaacc ggaattcact gtcgtagtcg tcctcgacga
    12301 tcaccgcgtc gttccgctcc gcccacgcca gcagcgccgt cctcctggag agtgacatcg
    12361 gcgtgccgag cgggaattgg tgcgacggcg tcgtatagat cagcctggtg cccttggcga
    12421 gcgcggcgac gtcgagccct tcggcgtcca ccggcacctt cgtgacccgg gcaccgtggg
    12481 cggtgaagag ccgttcggcc gggggatagc cggggtcttc gacggcgacc cgcgtgccgg
    12541 gttcgatcag gacccggccg atgaggtcga gtgcctgctg cgctccctga gtgaccacca
    12601 ggtcctcacc gccggcccgc accgatcggg cggcgccgac gtgccgggcg atcgccaccc
    12661 gcagtgcttc gagcccggcc gggtcggcat accccgacgg tgtcagcaga gacggccgca
    12721 aggcctggct gaccagccgt cgccaggtcc gcagcgggaa cagggccgga tccgggacac
    12781 cgacgcggaa gtcgaacgcg ggggccgacc ggtcctcgcc cagcggcacc ggaagggaac
    12841 gccagcgcgc ggcaggccgt actccaccgg cgggcgcggc acgctgcgtt cgcgccacgg
    12901 gatccgcgct cacgaacgtc ccgcgtccga cgtggccgct gaggaaccct tccgcggtga
    12961 gccgttcgta ggcgaccgcg acggtgttgc gtgagacgtc gagttcacgg gccagttccc
    13021 tggtcggcgg caggcgctcc ccggcgcgca ggcgtccgtc gatgatgccg tcgcggagct
    13081 gacggtagat ccgcgcggcc aggtcggtat gtccgtcgag gctgatgtgg aacggcacgg
    13141 tccgagccta tattggccca acgaggatga cggatattgg aactgggaag tggccaatcc
    13201 ggcccttagc ttgagtccat gaagcgactg atctcggccc agctgatcag ctccgtcggc
    13261 gacggcgcct actacgtgag ctcggccctc tacttcacgc tcgtcgtcgg gctttcaccc
    13321 gcgcaggtgg gcctcggcct caccgtgggc tgggcggtcg gctcggtggc ggggatcgcg
    13381 ctggggcagg tggcggaccg tcgcgggccc aagggcacgg ccgtcctcct ggcgctgggc
    13441 acggccgcgt cggtgacggc gttcctcttc gtcggctctg tattcacgtt cgtgatcgcg
    13501 gcctgcgtct acgcctgctt ccaatgcggt ctcggcgcgg cgaggcaggc gttgctcgcc
    13561 ggcttgatcg accccgccga gcgcacgacg ttccgcgccc ggttgcaggc gctttccaac
    13621 gcggggatcg cgatcggcgc cgcgctcgga ggcatcgcgc tggcgctggg gacccgagag
    13681 gccttcctga ccgtcttcgt cctcgatgcg ctggctttcg tcgccgcggc tctcgtgctc
    13741 cgcaaggtgc ctacggtggc tccgctaccg ccgcgggaag gagaaccgtc cgtggccgtt
    13801 ctccgtgatc gcccctacgc gttgctggcg ctgctcaaca tggtcatggt gctctacatg
    13861 ccgctgttca gcctggtcct gccgctgtgg atctcgacca ggaccgcggc cccgagctgg
    13921 ctggtctcgg cgatgctcgt gctcaacacg gcgagcgtgg tggtcttcca ggtccgcgtg
    13981 acgcgcggcg tgaccggtct gcgcagcgcc gccggctatg cccgttacgc gggactgctg
    14041 ctcttcttct cctgcctggt cttctcgttc tcggccatgg gcgaatccgc gtgggcggcg
    14101 gcgctgatcc tgcttctggg ggccacgctg caggtggtgg gggagatggc gcaggcggcg
    14161 ggctcgtggg aaatcgcctt cggcctcgct ccggaaggca aacagggcca gtaccaaggt
    14221 ttcttcggtg ccgggacggc catcgcccgc atgctcggcc cggtgctgct gaccgggctg
    14281 atcctcgtcg gcggcacggc gggctggatg gtactgggtg ggttgttcct ggtggcgggc
    14341 ctgctcaccg ggccggccgt ccgctgggcg gagcggaagt cgcggcccgg tgccgaagtc
    14401 agtcctcgag tgctcgccgg aagtgcacgg cgaggttgag ttccgcggct tcttccctgg
    14461 tatgccaggc gaaagcgtcg tgctcctcgg gatcgagcac gacttcgccc gcggtctctt
    14521 cggagagcgc gtacaccgcg gcgtgaatcc gcatcggcct gcccgcgacg tcgtcccagc
    14581 tgtgggtgcc gcgttcaccg gtcacgcgga cggtcagccc ggtctcctcg gcgaactcgc
    14641 ggaccacggt ctcggtgggc cgctcgccag gctcgacggt cccgcccggc aactcccagc
    14701 ggccgccgag gaaggatccc ggccgccgcc ggatgaacag gatcttcccg tcgcggatga
    14761 gcctgccgta ggccaagtac ttgtccgtca cgagcgcatc ttcccgtatc cgaaaggccc
    14821 gctcgatcga ggaccgaaac tgtccgcaat gcctcgtaac gtgggcttca tggaaaacac
    14881 cgagatccgc cccttccgcc tcgacatccc gcaggagcag ttggacgaac tgcacgcgaa
    14941 gctcgacagc gcgcgctggc ccgctccgct tcccggcgac ggctgggaca ccggagtgcc
    15001 ggtggcctgg ctgcgcggac tcgccgaata ctggcgcgac ggctacgact ggcgcgccgc
    15061 cgaacgcgag atcaaccgcc acccgcagtt caccactgtc atcgacggcc agcggatcca
    15121 cttcctgcac gtccgctcgc ccgaagccgg cgcgacgccg ctgatcctga cgcacggctg
    15181 gccgggttcg gtggtggagt tcctcgacgt catcggcccg ctcacggatc cgaaggcgta
    15241 cggcggcgac ccggcggacg cgttccacct cgtgatcccg tcgctgcccg gcttcggctt
    15301 ttcgggccct gtctcggatt ccggctggac catgccgcgg atcggccggg cgtgggcgga
    15361 actgatgcga aggctcgggt acgaacgcta cggcgtgcag ggcggcgacc tcggcgcttc
    15421 cgtgtcaccg gaggtggcga ggtccgcgcc ggacaaggtg atcggcgtgc acgtcaacgg
    15481 cgggctgacc ccgatgccgc cgatgtcgtt gtcggaggag gaactcgctt cgctcaccga
    15541 cgtcgaacgc gatcgcgtga agcggatcgg ggcgttcatg caggaggagt tcggctacat
    15601 cgcgatccag tcgacgcggc cgcagaccgt cggttacgga ctcgtggact ccccggtcgc
    15661 gcagctggcc tggatcatgg acaagttccg tgagtggacg catccccgcc cgaccttgcc
    15721 ggaagagatc atcgacaagg accggctgct gaccaacgtg atgttcacct ggctcaccgg
    15781 cacggcggct tcgtccgcgt acgtcggcta cgcgcaggcg gaaacctggg gagccgtcga
    15841 gaagaactcc ggcgtgccga cggcggcgct ggtcttcgcg cacgacgtcg ggatccggcg
    15901 gtactcggaa gacgcccaca cgatcgtgcg gtggaccgac gtcgatcgcg gcgggcattt
    15961 cgcggcgctg gaagaacccg agatcctggt ctcggacgtg cgggagttct tccgctccct
    16021 caaatgacga ggacggccgt ttccccgagg aagcggccgt attcgtccac ttcaggctcc
    16081 agttcggcga tgacggaccg cggaagcgtg gcgaagggct ccacgacgac cttcgtcagc
    16141 ttcgcggtcc gcttggtgtg ccacgttccg gcgatccggc cgtcgatcag cacggtcggc
    16201 gcgatcatcc cgccgccgga gttgacgcgt ttcgcctcgg ccgggtcgac gagcagcccg
    16261 cggtcacggt agcccagcag gtacgtgtcg aaggcgccga gcaggcgcgg ggggcacggg
    16321 ggagcggaca gctcggtctc cgagagggcg aagcgtttgc cgacgggaac ggggtccagt
    16381 gctgtgaaag ccttgcggca gagactgagc gggagtccgg accaggcgcc gaagtcctcg
    16441 gcggtcgcga cgccgtaggc ggtcagatac cggcgggcga gttccgtatc cggctcgtcc
    16501 ggcgtgcggc tctcggcgac ccattcgtcg aggagcacgt acgtcggctc cgttccggcg
    16561 tcgtggcctc ggcacaccag tccgcggttg gccgcgtacg ccaggagatg ggcgggtgcc
    16621 tgagacttcg cgtcgagcgt gatgccttcg gcggccagac cgtccaggat tccctgccga
    16681 gtgagtgcct ttcccggcaa gagatcctgg attttcccga gcgcgagttc gcagagttcg
    16741 tcggtgaggc ccagctgcct gcgtcgtccc tgccccgcct gggcgttacg cgggccgaac
    16801 agccggttca gccaccggag atcggccgtc ggcacgagat ggagtgtttt gcgcatcagc
    16861 caggtgcggg tgaccgcgtg ggacgtgtcg acgtccggag cggtcagccc ccggccacgg
    16921 gcccggatcg cgagccgggc ggcgggcgtc gactgcgcct ggaccgcggc gacggagccg
    16981 accacggtca gcacgtccgt ggcaggcacg gtcagcagct gagcgtgggc gcggacggcg
    17041 cggaggtcgt cgtcggacag tgtcacccgc tgacgatctc atgggcgtgc gccggttcgg
    17101 tgtgcgagac cctggccgcc gtggggaaac cccaccgtcc ggcgccgcgc tgaatccggc
    17161 tacggtggag ccgtgaccca gtcctcgtac ccggccgccc tgcggtggct gttgttgtgc
    17221 gtggtggcgc tgggtctggt gggtatgcac cacgtcgtcg ccgactccgg ccacgacgcg
    17281 gggcactccg ccgtcgcgat ggcggatccg tgttgcgcgg acgcgccttc gcacgacgac
    17341 ggtggacaca atggactgca tctgtgtctc gcggtgctcg ccgcggccgt gctgctgatc
    17401 gtctcctggc tgctcgtccg gaccggacgg acggtggcga cctggaagtc gaggcgcgtc
    17461 ggcggttcgg cgtcgggccg cgatccgccg cgctggagac cggtacccga aagattgtcg
    17521 ctcctttgcg tgttgcgggt gtgacaggcg ggttcgtccc gccctgcccg aaaccgattc
    17581 gaggaagaac catgaccagc aggaaactgg ccggggccgc gctcgccgcc ctggcctcct
    17641 tcgccgtgct caccggctgt gccagctccg acaccgcttc caccggacac gccgcgtcca
    17701 cggtgaaggc gccggatccc cagcaggccg gccacaacca ggccgacgtc acgttcgcgc
    17761 aagggatgat cccgcaccac gaacaggcgc tcaagatggc gaaactcgtc gacggccgca
    17821 ctcgcaacgc gaaggtcgtc gacctggcca cgaggatcca gaaggcgcag gatccggaga
    17881 tccagcagct gaacggattg ctgaaaggct ggggagtggc gccgtcgggt gagcactccg
    17941 gacacggctc cgcgtccggc atgatgaccg aggacgatct ggagaaactc ggcaaagcca
    18001 aggacgccgc gttcgacaag cagtggctcg agatgatggt caaacatcac gagggtgcgc
    18061 tcgagatggc gaagaccgcc ttgcagcagg gtagcaacgc cgaggtgaag gcgttggcgc
    18121 agaaggtgat cgacggtcag caggccgaga tcaccgagat gcgcgccctg ctcggctgag
    18181 ccgggacggt ggcgcgggcc gacgtcgtcc ggcccgcgcc accgcctctc gggagtgcgc
    18241 gcagtcgacg tccggctccg ccgtgctcga cgtcggctgt ggtgccgggc ttgccgtatc
    18301 cgagttgtcg cggctgggtc tccgcgctgt cggtgtcgac ctttcggccg agatggcgga
    18361 agaggcgcgg caggtgtcgg tcgacggcgt gatcgggtac ttcgctgggg agtcgttcct
    18421 gcgcgggctg gcggacatag ctgtccgggt cggcgcggtt tccgtggcgg aaggaagatc
    18481 tggctggcgg atcggatcgg tgaggtggcg gtgccgcggt tcttggcttc cgggtggtgt
    18541 gaggtgatcg tcgccgaaaa tcggcgactg gatcactgat ggtttcacgg tctgcggaaa
    18601 tcgggcggtg gctggagatt tctgttgccg tgtaacggaa atgttcttga gtgcggaaac
    18661 tgtcggtggt cggttgtagc ttctgtctgt ggacacacgc aacgccactg tggcgctact
    18721 caaggaaatc acctcacctg atgccttgcg ggaggtcaac gccgccctgg attcgttgga
    18781 ggacaacgat gccatcgacg ccgccgtcgc ggcatcggaa ggaatcgcac gcctggaagc
    18841 ggtccacttc cgcgcactcg cacagctcac ccggcaccgt gacgacgcgt caagcgtggt
    18901 acaggaagtc gcgttcgcac tgtccattgt ggatggtcac gcggccggtc tggtgtccac
    18961 ggcggcggca ttgaccaccc gtctcccgcg cacactgggg ttgctggacc gtggccaggt
    19021 cggcggctat ggggcgatga aagtcgccac cgccaccgcg tggctgtcgg acgaggacgc
    19081 ccgcgcggtc gacgacgtcc tggaagaccg cctaccggga cggaactccg agcagatccg
    19141 gaaagcagcc aaccacgccg cgatgatggc cgaccgcgac ggcgccgccc gccgcgcgga
    19201 acggcaccgt gaggggcgcc gattgtcgat ccggcagggt gagaccggcg tcgcgtcgat
    19261 cgaagtcgaa gacggccccg tcgagaaagt cgccgccgcc tacacccgca tcgaccgcga
    19321 ggcacgcgcg ctcaagaccg gcggggagac ccgcaccctg gatcaactcc gcgccgatat
    19381 cgccctcgat ctcatgctgg gcggccaggg cggcaaggcc gaacggtccg aagtgttcct
    19441 ctacatggat ttggatacct atctcggggt gaacgacgac cccgccgaac tggccggaca
    19501 cggccacatc cccgccacac tggcccggcg gatcgcgtcc gggccggaca cggtgttgcg
    19561 gcggatcatc accgaccctt tgtcggggca ggttctggat ttgggtcggg atcggtatcg
    19621 gccgacggcg gggttgggtg agttcgtgcg ggtgcgggac cgggaatgcc gaagacccgg
    19681 ctgccaccgc cccgcccaag cctgcgacct cgaccattcg gtgccgtggc agcacggtgg
    19741 tcacaccgcc gataccgagc tggtcgacct gtgccgccgc gaccaccggc tcaaggacga
    19801 acccggctgg atctaccggc tggccgagga cggcactctc accatcacca cgcctacggg
    19861 gcacagctac gacagcacgc caccaccact acacgaaccc cgcacccaag agccaccatt
    19921 ctgaaaccgt cgccggaaaa cggccacggg ggctatcccg tgatcggtgt ttccgacgtt
    19981 gttgatcagt aggtttcggc tcccggccac ggtgcctcgg cgcgatgggg tgatcggcgc
    20041 attcggtctc ggcttcgtcg ccgggatacg gctatggctg gaccgggtga acgggttccg
    20101 aggtttcggc tcaccaccgg ccgcgctgcg aggtgtggtc gccgaaatac ggtcattgct
    20161 atcgcctcat cgagcagcgc gtaccagtga tgcgcttgcc tggcccctcg aggtcaacgc
    20221 tgcgcggctg cgggatcgga ccacgacaac gcgggagccg gccgcagcgg cgccaccata
    20281 atcgcggtct gtgacgcagg caggcgcgca gtcgcggacc gggggcctgc tgactgtgcg
    20341 aatgcagcgc gggcattggg ctcaaggccg cgttgccttg gctttcatgg cttgaaagca
    20401 gaatgaaagt gctcccggga tcgtaggtgc gccgcccgag gtgggcgggg aagcagatga
    20461 gacgagtccg tatccgcccc ggcaggtacc tggtccgggc gctgtcggaa gatcacgagg
    20521 ggattgtcat gagagttcgt tcgagggtcg tcgcatgtct tgtgtcggtg ttcatgatgc
    20581 tcgcactggc gttcgtcggc gcgggatccg cggcggcgga ccagtcgaaa tccatctccg
    20641 gggcgtcgcc ggacggcggc gcgagcttca gcgggacgtt gacgtggacc ggccggggcg
    20701 gtttcaaggc cgacgtcacg ttgaaggacg caaagtgcga cgggaacccc gtctacttct
    20761 acttcatcat caacaagggg tggacgagcg agtggcaggg caagcggcgc gacaacaacg
    20821 agggctgcgg caagaccatt acctggaagg gtatcgcggg gtctgacagc aacggcatct
    20881 acggtcccac gctgcgggtg tgcacggaca tccggccggg ggtggactcc tgcagggagt
    20941 acggctacga caacccgtac ttcccctaac ccgcctcacc cgccgatcgg ctcgggctcc
    21001 cgggccgatc ggcgcggacg gtactggtg
//
