LOCUS       NZ_JAEVFI010000019     22724 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Streptomyces sp. JJ66 scaffold19_size86796, whole genome shotgun
            sequence.
ACCESSION   NZ_JAEVFI010000019
VERSION     NZ_JAEVFI010000019.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. JJ66
  ORGANISM  Streptomyces sp. JJ66
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 86796)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Draft genome of Streptomyces sp. JJ66
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 86796)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2021) Marine Biotechnology and Ecology Division,
            CSIR - Central Salt and Marine Chemicals Research Institute, G.B.
            Marg, Bhavnagar, Gujarat 364002, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2017
            Assembly Method                   :: Velvet v. V 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 320.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019303495.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 03:51:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,515
            CDSs (total)                      :: 4,446
            Genes (coding)                    :: 4,340
            CDSs (with protein)               :: 4,340
            Genes (RNA)                       :: 69
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 31 of 106
            Pseudo Genes (incomplete)         :: 82 of 106
            Pseudo Genes (internal stop)      :: 3 of 106
            Pseudo Genes (multiple problems)  :: 9 of 106
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:22:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 29745
            Orig. end                         :: 52469
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAEVFI010000019.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22724
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22724
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22724
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12724](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12724
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    224..235
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: weak, score: 17.94"
                     /tool="antismash"
     gene            582..1196
                     /locus_tag="JJV70_RS15370"
                     /old_locus_tag="JJV70_15370"
     CDS             582..1196
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019433073.1"
                     /locus_tag="JJV70_RS15370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15370"
                     /product="DedA family protein"
                     /protein_id="WP_219048540.1"
                     /transl_table=11
                     /translation="MLETLGTLVYEPWIYGLIVLSVLLDVFLPLLPSGILLVTAATAAT
                     AELATGPGAHLPEALVLLLCAATASVLGDFAAFSLARYGGRRFADAVARSHQLTSAQQR
                     LGGVLARGGGPLVLLARFAPAGRSVMSFAAAAARRRTRDFLPWSATAGLLWATYSVGLG
                     YFGGRLFGVTWGGTALSLAALTAAGLLAAHLLRRRPTASTS"
     gene            1238..1777
                     /locus_tag="JJV70_RS15375"
                     /old_locus_tag="JJV70_15375"
     CDS             1238..1777
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952829.1"
                     /locus_tag="JJV70_RS15375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15375"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_219048541.1"
                     /transl_table=11
                     /translation="MADTPRAWTTRPERTDAEGASADAAAVRRIHLDAFPASEEADLID
                     HLRASGAWLPGLSWLAKTPQGEPVAHALLSRCHVADHPALALAPCATRPAHQGRGAGSA
                     AITAALDAARAAGEHTVVVLGHPGYYPRFGFRPCADFGITPPPGHDWPTEAFLVLALDT
                     GPLPSGAVRYPPPFHL"
     gene            complement(2029..2949)
                     /locus_tag="JJV70_RS15380"
                     /old_locus_tag="JJV70_15380"
     CDS             complement(2029..2949)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (14-243). E-value: 2e-36. Score:
                     117.7. Matches aSDomain:
                     nrpspksdomains_JJV70_RS15380_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020555988.1"
                     /locus_tag="JJV70_RS15380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15380"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_219048542.1"
                     /sec_met_domain="ADH_N (E-value: 1.2e-10, bitscore: 34.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 8.4e-13, bitscore:
                     41.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAVTYDTYADDNSRLTVGEMPDPKVGPDQVLIEVRAAGVNPVDW
                     KLMTGGLDGVLDAVFPVIPGWDVAGVVRALGMDAPEFAVGDEVMAYARKDMLHAGTFAQ
                     YVAVNATHVARKPAALDWARAGGLPLAGLTALRSLDRLAVGPDDVLLVHGASGGVGGFA
                     VQIAVDRGARVIGTASPRNHDYVRALGATPVAYGEGLTDRVRELAPEGVSAVADFAGGQ
                     LETTLAVLAPKGRHASVVDGDVVEHGGHLVWVRPDGAALTELAGLVERGAVTVEVERTF
                     PLEQVGAAFDASRTGHARGKLVITP"
     aSDomain        complement(2221..2907)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJV70_RS15380_PKS_ER.1"
                     /evalue="2.00E-36"
                     /label="JJV70_RS15380_PKS_ER.1"
                     /locus_tag="JJV70_RS15380"
                     /protein_end="243"
                     /protein_start="14"
                     /score="117.7"
                     /tool="antismash"
                     /translation="RLTVGEMPDPKVGPDQVLIEVRAAGVNPVDWKLMTGGLDGVLDAV
                     FPVIPGWDVAGVVRALGMDAPEFAVGDEVMAYARKDMLHAGTFAQYVAVNATHVARKPA
                     ALDWARAGGLPLAGLTALRSLDRLAVGPDDVLLVHGASGGVGGFAVQIAVDRGARVIGT
                     ASPRNHDYVRALGATPVAYGEGLTDRVRELAPEGVSAVADFAGGQLETTLAVLAPKGRH
                     ASVVDGD"
     CDS_motif       complement(2449..2502)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJV70_RS15380_0001"
                     /evalue="8.80E-06"
                     /label="PKSI-ER_m5"
                     /locus_tag="JJV70_RS15380"
                     /protein_end="167"
                     /protein_start="149"
                     /score="18.3"
                     /tool="antismash"
                     /translation="LLVHGASGGVGGFAVQIA"
     gene            complement(3175..3495)
                     /locus_tag="JJV70_RS15385"
                     /old_locus_tag="JJV70_15385"
     CDS             complement(3175..3495)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009718339.1"
                     /locus_tag="JJV70_RS15385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15385"
                     /product="antibiotic biosynthesis monooxygenase"
                     /protein_id="WP_219048543.1"
                     /transl_table=11
                     /translation="MSIVKINVLTVPDEQREVLEQRFGARAGSVENSDGFEWFELLRPL
                     EGTDQYLVYTRWRDEEAFQAWMEGPMKAAHQGGGGQQHKPAASGSTLWSFEVVQQAGPK
                     QG"
     misc_feature    complement(3540..3553)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            complement(3550..4440)
                     /locus_tag="JJV70_RS15390"
                     /old_locus_tag="JJV70_15390"
     CDS             complement(3550..4440)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010637596.1"
                     /locus_tag="JJV70_RS15390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15390"
                     /product="ECF transporter S component"
                     /protein_id="WP_219048544.1"
                     /transl_table=11
                     /translation="MTVAPDSSRTRPVRLGRRSTLALALVSAVGIAAFGWPLLADSASG
                     LAHSNDAPWLFAALLPLLLAVVVATIADSGLDAKAIAMLGVLAAAGAALRPLGAGTAGL
                     EPMFFLMVLAGRVLGPGFGFVLGAVTMFASALLTAGVGPWLPFQMLALGWVTMGAGLLP
                     RPHRLRGRRELLLLAAYGAPAAVAYGIVMNLQGWPYLGGLGTAISFVPGDPVAANLARF
                     TAYWLATSLGWDLPRAALTVVLTLTTGPTLLRALRRATHRAAFTTPVTFTPPSGTPDSP
                     QSPPGPGSGGRPASA"
     gene            complement(4437..6101)
                     /locus_tag="JJV70_RS15395"
                     /old_locus_tag="JJV70_15395"
     CDS             complement(4437..6101)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605911.1"
                     /locus_tag="JJV70_RS15395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15395"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219048545.1"
                     /transl_table=11
                     /translation="MIRFENVQVTYADAATPAVRGLDFTVPEGELVLLIGPSGVGKSTL
                     LNAVCGLVPHFTGGTLHGRVTVDGRDTRTHKPRELADVVGTVGQDPRAHFVTDTVEDEL
                     AYGMESIGLPPATMRRRVEETLDLLGLAELRDRPIGTLSGGQQQRVAIGSVLTTHPRVL
                     VLDEPTSALDPGAAEEVLAVLQRLVHDLGTTVLMAEHRLERVVQYADQVLLLPERGAPA
                     QLGDPAELLAHSPVRPPVVQLGELAGWSPPPLSVRDARRRAGPLRERLAPATPQPPRPR
                     PDAASPADEARGAATRPAEPAPLAQVTTLDVRRGRTGVLHRVSLTVQAGETVALMGRNG
                     AGKSTLLNTLVGLHAPAHGSVRVGGHTPHRTKPGQLLRHVGLVPQDPRDLLAADTVAAE
                     CAAADRDAGADRGTCRALVGELLPGVADDVHPRDLSEGQRLVLALAVVLTAAPPLILLD
                     EPTRGLDYAAKHRLTEVLHDLAARGHAIVLATHDVELAAELADRVLVMAQGEVVADGPT
                     ADVVVSSPAFAPQTAKVLAPQPWLTVPQVRRALGATS"
     gene            complement(6098..7414)
                     /locus_tag="JJV70_RS15400"
                     /old_locus_tag="JJV70_15400"
     CDS             complement(6098..7414)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016906690.1"
                     /locus_tag="JJV70_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15400"
                     /product="energy-coupling factor transporter transmembrane
                     protein EcfT"
                     /protein_id="WP_219048546.1"
                     /transl_table=11
                     /translation="MTPGPLAALRAPLADRFTALHAGAWWLWALGLATAASRTTNPLLL
                     LLLVAVAGYVVAARRTDAPWARSYGVFLRLGLLVLVLRLLFAVVLGSPVPGATVLFTLP
                     EVPLPGWAQGVRLGGRVSAEALYFVLCDALRLATLLICIGAANALASPARLLKSLPGAL
                     YEVGVAVVVAVTFAPNLVADVLRLRAARRLRGRPDRGLRSFAQVALPVLEGALERSVAL
                     AAAMDARGYGRTAPVPRAVRHATTACTLGGLLGVCAGTYGLLTEDGTAFGLPVLGAGVL
                     LALVGLRLGGRRTVRTRYRPDRWGVRAWLVSGSGLAVAAGVLAVAVSDPVALRPPAVPL
                     TAPVLPPGAVAACLLGLLPALVAPLPGARGDRGRSRTPDTPDEAPPAARQEGPRGGVRA
                     RRQADAPPQPSQPSQPSQPPQPSRRTAPASVRAPRRPQP"
     gene            complement(7411..8124)
                     /locus_tag="JJV70_RS15405"
                     /old_locus_tag="JJV70_15405"
     CDS             complement(7411..8124)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018518433.1"
                     /locus_tag="JJV70_RS15405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15405"
                     /product="SCO2322 family protein"
                     /protein_id="WP_219048547.1"
                     /transl_table=11
                     /translation="MRAAARTACAVALGTLLLVLGAAPAQAEGYRYWVFWTWDADRPEG
                     AAWSYATEGPGTLRPADGAVLGFRFAVSENSAEADRPRQEADFADVCADTAPREGHKRV
                     ALVIDPGTAGDAPPGERPPEPMRACARVPADGTAAEALAATAKPLRYDSSALLCAISGY
                     PETGCGEQVSADEGSGGEGSGAADTTREAEAAGEDATEDDAGDAGVSTFGTVAGVVAVV
                     LLAGAAGWQVRRRRS"
     gene            complement(8124..9410)
                     /locus_tag="JJV70_RS15410"
                     /old_locus_tag="JJV70_15410"
     CDS             complement(8124..9410)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103398.1"
                     /locus_tag="JJV70_RS15410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15410"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_219048548.1"
                     /transl_table=11
                     /translation="MFLRRCAVALAASTVLCASAAPLALADDSPSPTPGASLPEELYGT
                     ADPQYDGVFRHAHALLAQDAVGVTPAEAAVSWLTGQQCDDGAFTAYRPDPGQACDDTTV
                     RDTNATALAVQALAAVAGEDDEPVGEAVQWLQSVRNDDGGWGYNPGGASDANSTAVVMG
                     ALLAAGEKPQAATHDALRGFQLGCEAPEEERGAFAYQPGEDGKLAPNALATAAAALAAQ
                     ESGLAVAADSAGDAAPELPACTDGDAFAREDAAQAGAAYLHTQLAAHDGHLMSALPGAE
                     DQPDYGTTTLAVLTLAGGGYDVEQPLAWLAEHHTEWPGVQESPAALAQLVLAVRAAGGD
                     PTAFGGTDLVAQLAATGPAPQEGEPQEQEKEGAGDGSEDGFDAALWIGVAAAIGGALFA
                     TGVFARRKNSGSGDTADSANPASGTGSDH"
     regulatory      complement(9576..9666)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(9841..9856)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            10001..12724
                     /gene="lanKC"
                     /locus_tag="JJV70_RS15415"
                     /old_locus_tag="JJV70_15415"
     CDS             10001..12724
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019983511.1"
                     /locus_tag="JJV70_RS15415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15415"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_219048549.1"
                     /sec_met_domain="micKC (E-value: 1.2e-230, bitscore: 760.5,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.7e-12, bitscore: 38.0,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.3e-08, bitscore:
                     25.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSRYEAYCLADGRFYETPDRLSTGSGNRDGGLETARRPVPSGWR
                     HARHGDWLELRPQDGAFPAQGWKIHVSATLANADAVAARVWDYCVPRGIPFKFVPDLHL
                     LHLRNAKYASRATSGKAVTVYPVDEEQLHTVLRELDARLAGEPGPYILTDLRWNQGPLY
                     VRYGGFAPRTCVNEHGQLVPAIEDAGGTLIPDRKDPVFTVPAWVTLPPFLQPHLDARNA
                     SSVAGLPYTIERALHFSNGGGVYAGKDTRTGEDVVLKEGRPHAGLAADGADAVRRLERE
                     KAALDRLAGTGVAPGVRDWFTLEGHRFLVMDYLPGQPLNHFYAQRHPLLAGDPDPRAVA
                     DYTQWALAIHQAVAEAVAAVHARGLVFNDLHMFNIMVAPDEKSVSLLDFEAAAPAADDP
                     RQIVAHPGFVAPGDRRGYAIDTYALACLRLALFLPVTTLLAVDRRKASHLAAVIAEQFP
                     DVPGEFLGEAVAEIEGRRPAPGPQDGTGSTGTPDDAGNTAATRTPAREANPPGPAQHPA
                     PHPADPEPHVAPADWPRSRDAMVRAILASATPERDDRLFPGDIAQFTEGGGLGLAYGAA
                     GVLYALAETGAPRYERGEQWLLDHTGQLPPRTPLGLYTGLLGVALLLDRLGHTERAARL
                     VEQVLAERWQHLGHDLEGGLAGVGLALDHLGERTGDTALHDAAGQALHRAADAVAQATA
                     ADGRIPRAGLLHGATGTALLALRRYERTGESALLEVAADALRRDLARCVPDQHGALHVD
                     EGARTMPYLGAGSVGIAAVLDDYLRHRPGQEAFEEARRAILPAARSRFYAQPGLFRGRA
                     GMVWHLARTTTPGATPADLARQLDGLSWYGMAHGGGLAFPGDQMMRLSMDLYTGTAGCL
                     LAVGAARHDAPVRLPFLPPLTRPEPAAPPQRAARPH"
     gene            12784..12906
                     /locus_tag="JJV70_RS15420"
                     /old_locus_tag="JJV70_15420"
     CDS             12784..12906
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="JJV70_RS15420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15420"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_219048550.1"
                     /transl_table=11
                     /translation="MALLDLQKMETPDNGYGDVGSNVSLLICDKHSGASTILCL"
     CDS_motif       12784..12846
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQKMETPDNGYGDVGS"
                     /locus_tag="JJV70_RS15420_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12847..12906
                     /prepeptide="core"
                     /locus_tag="JJV70_RS15420_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="12.50"
                     /molecular_weight="1915.3"
                     /monoisotopic_mass="1914.0"
                     /core_sequence="NVSLLICDKHSGASTILCL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQKMETPDNGYGDVGS"
                     /leader_location="[12783:12846](+)"
                     /alternative_weights="1933.3"
                     /alternative_weights="1951.3"
     misc_feature    12791..12805
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 15.7"
                     /tool="antismash"
     gene            13121..14941
                     /locus_tag="JJV70_RS15425"
                     /old_locus_tag="JJV70_15425"
     CDS             13121..14941
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569990.1"
                     /locus_tag="JJV70_RS15425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15425"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219048551.1"
                     /transl_table=11
                     /translation="MTPADRLLFDALRRSAPRATAIGCVTTADAATALALPAVLGRTLD
                     LLLTGEPATGWLACSAALLAALFLLDAAETVLTGTTTAHATARLRTRLVGHLLAAGPAG
                     AARFSRGDLVTRGTALAAQAGTAPASAAALLSALALPVGGITALLLIDVRLAAVFLLGA
                     PLLVLLLRAFARSSGDAVARYQQAQGLIAGRLAEALAGARTVAAAGTLERERARILGPL
                     PQLSREGHRMWRVQGRATAQAAVLVPLLQLAVVATAGWLLADGQLTVGALLAAARYAVL
                     ASGIGVLTGRVAALVRARQAAVRLAEVHAVPAVPYGTAPLPDGPGTLELRGVSAVRDGR
                     TVLSGVDLTVPGGATVAVVGRSGSGKSELARLAGKLAEPSTGTVLLDGLPLDTVDAASL
                     RAAVGYAFERPALVGGTLAGTIGLGPAPPGHAVVLAAARAARADSFIRTLPEGYATPCA
                     DAPLSGGEVQRLGLARAFAHAGRLLILDDATSSLDTSTERQVTAVLFAPERTRTRLVVA
                     HRATTAARADLVAWLDAGHLRALAPHARLWHDPAYRAVFTAPDAAPDAAAAPGADTTRP
                     ADAGTPAPTAAGTADAAPGTAGIAVEAADA"
     gene            14934..16778
                     /locus_tag="JJV70_RS15430"
                     /old_locus_tag="JJV70_15430"
     CDS             14934..16778
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014627603.1"
                     /locus_tag="JJV70_RS15430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15430"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_257574011.1"
                     /transl_table=11
                     /translation="MREATRTTTKEPGTRGLFAAGARRLRQRPRALGALAGWSVLESAQ
                     TFLLGLAVAHALDDGFLRGSVGTGLAWLALGALGVLAGSFGAGRVYRAVATLAEPMRDL
                     LVERVVGTGLHAAVRRGRATDSGVVSRLTHQVEIARDSFAGLLMAGRAFAFTSAAALAG
                     LASLHPLLLLVVLPPLALGLLVFGLSLRPLARRQRDFLIADEAIAEHLGETAGGLRDVV
                     AAGAEEPTRTEAAARVAAERRAAEALARWGVTRAAALGIGGRLPVVLLLVLTPWLLARG
                     VSAGALAGALTYLLHSLIPALESLVHGLGNAGARLAVVVGRLRGADDAPPTAPPAPPAP
                     PTPRTPGTALSLRGVTFAYGRRAQPVLDGVNLCLPRGGHLAVVGTSGTGKSTLALLLAG
                     LLTPDAGHLAVRGPVALVPQEAYVFTGTLRANLTYLCPDPVPDAALHRALEATGGADLA
                     GRLGGLDADVDPERLSAGERQRLALARAYAAPASLVVLDEATCHLDPAAEARAEQAFRR
                     RPGTLVVIAHRISSARRADLVLVLDGARSRCGTPGEVASASARYRELAGAWEAAVPDAA
                     DASGTASAASTASSQPAGALGDTDGVHPVAGAGLPGDR"
     gene            complement(16701..17306)
                     /locus_tag="JJV70_RS22840"
     CDS             complement(16701..17306)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010354522.1"
                     /locus_tag="JJV70_RS22840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_374227307.1"
                     /transl_table=11
                     /translation="MIRVLLVHDTRLLRSGLAQLLSKAQDMDVSTAPWRQAGRAARSAG
                     ADVCVADLDEGAGGEQRDLDALRRELPAPTCRVLVLATPGRPGTLRQAVEAGAQGYVNK
                     DASPQELLAGIRQVAKGERFVDASLAFGFLQATQLPLTRRELSVLSLAAEGASVAEIAS
                     SLHLSNGTIRNYMSAITRKTGARNRVDAICIAQRSGWL"
     gene            complement(17492..18112)
                     /locus_tag="JJV70_RS15435"
                     /old_locus_tag="JJV70_15435"
     CDS             complement(17492..18112)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016326104.1"
                     /locus_tag="JJV70_RS15435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15435"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_308294829.1"
                     /transl_table=11
                     /translation="MPHAPRRGRSGQQRARRQGILRAATDLARGGGFEAVQMREVAESA
                     GVALGTLYRYFPSKIHLLVAVLQDQLRLLHGTLDADPPHGPGAGARVAETLMRAFHAMR
                     DEPHLASAMVRALTSADRSVRAEVDTVLEITSGIVLDAMKAGGAPTPAQLSAVRVIEHT
                     WFSLLISWLSGRTTIETVGTDLKTVCRLAEAHPANRETSEGAQ"
     misc_feature    complement(18552..18565)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.98"
                     /tool="antismash"
     gene            18635..19987
                     /locus_tag="JJV70_RS15440"
                     /old_locus_tag="JJV70_15440"
     CDS             18635..19987
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005318288.1"
                     /locus_tag="JJV70_RS15440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15440"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_219048553.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.2e-26,
                     bitscore: 85.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAKAIRDAASAPRHAPGPGGGRPLRIALLTYKGNPFCGGQGVYV
                     RHLSRELARLGHRVEVIGAQPYPVVDEGVTLTELPSLDLYRQPDPFRTPRRAEYRDWVD
                     ALEVATMWTGGFPEPLTFSLRARRHLAARRGQFDVVHDNQTLGYGLLGGPPVLGAPLVT
                     TIHHPITVDRQLDLAAADTLRRRLSVRRWYGFTRMQRRVARRLPSVLTVSGTSRQEIVD
                     HLGVRGDRVHVVHIGADTDLFTPDPAVPQVPGRIVTTSSADVPLKGLVYLVEALAKVRT
                     EQPDAHLVVVGRRADDGPVAAAIERFGLHAPDRTGRRPVEFVKGITDRELADLVRGAQL
                     ACVPSLYEGFSLPAAEAMATGTPLIATTGGALPEVAGPDGETCLAVPPGDPGALAGALA
                     RLLADAPLRARLGAAGRARVLSRFTWRQAALGTAAHYREAIARATAARSRT"
     gene            20034..20795
                     /locus_tag="JJV70_RS15445"
                     /old_locus_tag="JJV70_15445"
     CDS             20034..20795
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016468737.1"
                     /locus_tag="JJV70_RS15445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15445"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_219048554.1"
                     /transl_table=11
                     /translation="MLTVDFSRFPLAPGDRVLDLGCGAGRHAFECYRRGAQVVALDRNA
                     EEIREVATWFAAMEEAGEAPPGATATAMEGDALALPFPDDSFDVVIISEVMEHIPDDKG
                     VLAELVRVLRPGGRIAVTVPRYGPEKVCWALSDAYHEVEGGHIRIYRATELLARLREAG
                     LRPYGTHHAHALHSPYWWLKCAFGVDNAQALPVRAYHKLLVWDIMKKPLATRLAERALD
                     PLIGKSFVAYATKPHLPRAAASAHAAAEGAA"
     gene            20792..21862
                     /locus_tag="JJV70_RS15450"
                     /old_locus_tag="JJV70_15450"
     CDS             20792..21862
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103414.1"
                     /locus_tag="JJV70_RS15450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_15450"
                     /product="prenyltransferase"
                     /protein_id="WP_219048555.1"
                     /transl_table=11
                     /translation="MTSPERTERLVLPGVLTAEQASQTVAGILAQQRPDGAIPWFRGHH
                     LDPWDHVEAAMALDTAGEHTAAEAAYRWLADHQLPDGSWYAAYADGAADTPTDRGRESN
                     FCAYVAVGVWHHYLSTGDDTFLDRVWPVVVAAVDFVLALQQPGGPLAWKREDDGTVRTE
                     ALLTGCSSSYQAVRCALAIAEHREEPQPDWELAVGRLGHAITHHPERFADKSRYSMDWY
                     YPVLAGALTGPAAKARIEEGWDRFVVPGLGVRCVTPNPWVTGGESAELALALWTMGEAD
                     RAVEILRSMAHLRAPNGMYWTGYVFADDAIWPREQTAWTAGSLLLATAALGGDEATTEI
                     FTPANLPPGLPPDCCG"
ORIGIN
        1 ggttgacgta ggcggggtcg gaggagtgtc ccgggggagc caccacgttc tggtagtgcg
       61 gaccggcgtc cgccgggtcc gggccgcacg gccgggtgtg cgcgtgcgcc ccgtacgtcc
      121 gctccggagc gacgccgcgt acccgcagct ccaccgtcat cgcaccctcg ctcacccgct
      181 gccggacggc gacgcgcgcg cccggcggca ccaggccggg agcgtacgtg accgcctgcg
      241 gcacgtgtcc gtcccggacg ggctggtagt ccgccgccgt gctgaactgg tacgccgacg
      301 agccgtctga cgcgacgtcg ccgtggtgcg ccaccgcagc ggggacgagc gcgagcgccg
      361 ccgccatcgc cgctgccgcc gggcctgccg gacctgtcac catgcctgtg ctccctgtcg
      421 tcgcgactgc tccccgaacg ccgccgccca ccctgcccca ccggacccgc ggcctgccgc
      481 gcagcacggt gtaacgggaa cccacgcgag ccgtgcgagg gaagcggcgt acgctggacg
      541 gcggtaaccg ctccccgccg ggagcgagac ggggagtgac ggtgctggaa acgctgggga
      601 cgctggtcta cgagccgtgg atctacggcc tcatcgtgct ctccgtgctg ctggacgtct
      661 tcctgccgct gctgcccagc ggcatcctgc tcgtcaccgc cgccacggcc gccaccgccg
      721 aactggccac cggcccgggc gcgcacctgc cggaagcgct ggtgctgctg ctctgcgcgg
      781 cgacggcctc cgtcctcggc gacttcgccg ccttctcgct cgcccgctac ggcggacgcc
      841 gcttcgctga tgccgtcgcc cgctcccacc agctgacctc ggcgcaacag cggctcggcg
      901 gcgtgctcgc ccgaggcggc ggccccctgg tgctgctggc ccgcttcgcc ccggccgggc
      961 ggtcggtgat gagcttcgcg gcagccgccg cccgccgccg cacgcgggac ttcctgccct
     1021 ggtccgccac ggccgggctg ctgtgggcca cctacagcgt cggcctcggc tacttcggcg
     1081 gacggctgtt cggcgtcacc tggggcggga cggcgctctc gctcgccgcg ctgaccgccg
     1141 cgggcctcct cgccgcccac ctgctgcgcc gccggcccac cgcgtccacc tcctgaccgg
     1201 gcggacgcca gcggcgcggc gtgcgaccat accggccatg gccgataccc cccgcgcctg
     1261 gaccacccgc ccggaacgca ccgacgccga gggcgcgtcc gccgacgccg cagccgtccg
     1321 ccgcatccac ctcgacgcct tcccggccag cgaggaggcc gacctcatcg accacctgcg
     1381 ggcctccggc gcctggctgc ccggcctgtc ctggctcgca aagacaccgc agggcgaacc
     1441 ggtggcgcac gccctgctct cgcgctgcca cgtggccgac cacccggcgc tcgccctcgc
     1501 cccctgcgcg acccggcccg cccaccaggg gcgcggcgcc ggttcggccg ccatcacggc
     1561 cgcgctcgac gccgcccgag cagcggggga gcacaccgtc gtcgtcctcg gccaccccgg
     1621 ctactacccg cgcttcggct tccgtccctg cgccgacttc ggcatcacgc caccgcccgg
     1681 ccacgactgg cccaccgagg cgtttctcgt cctcgccctg gacaccggcc cgctcccctc
     1741 cggagccgtg cgctacccgc cgcccttcca cctctgacgg ccaccggccg cccgccgcga
     1801 caggcggccc agaggcggga gacggcgggc agaccgcgcc gaccggaccg gccaggcgta
     1861 gggcgagccc accagccccg cgccagcccg caggggagcc ggagcccctg gcctggcctg
     1921 gagggacgga taccccctgt cggagagcat cgggagtccc gccgcaccga cctgccgggg
     1981 acggcgccga cccgccgccc gccgccggac gtcagccctc cgcgcacctc acggggtgat
     2041 gacgagcttg ccgcgtgcgt ggccggtgcg gctggcgtcg aacgcggcgc cgacctgctc
     2101 cagcgggaac gtccgctcca cctccacggt gaccgccccg cgctccacca gccccgccag
     2161 ctcggtcagc gccgcgccgt ccgggcgcac ccacaccagg tggccgccgt gctccaccac
     2221 gtccccgtcc acgacggagg cgtgccgccc cttgggcgcc agtacggcca gtgtcgtctc
     2281 cagctggccg ccggcgaagt cggccaccgc gctcaccccc tcgggggcca gctcccgtac
     2341 ccggtcggtc agcccctcgc cgtaggcgac gggggtggcg ccgagcgcgc gcacgtagtc
     2401 gtggttgcgg ggcgaggcgg tgccgatgac ccgggcgccc cggtccaccg cgatctgcac
     2461 cgcgaagccg cccacgccgc cggacgcacc gtgcaccagc agcacgtcat ccgggccgac
     2521 cgccagccgg tccaggctgc gcagcgcggt cagcccggcc agcggcaggc cgcccgcccg
     2581 cgcccagtcc agcgcggcgg gcttgcgggc gacgtgggtc gcgttcacgg cgacgtactg
     2641 ggcgaacgtg cccgcgtgca gcatgtcctt gcgggcgtag gccatcacct cgtcgcccac
     2701 cgcgaactcc ggggcgtcca tgcccagggc ccggaccact ccggccacgt cccacccggg
     2761 gatgacgggg aacaccgcgt ccagcacccc gtccagtccg ccggtcatca gtttccagtc
     2821 caccgggttg accccggccg cccggacctc gatcagcacc tggtccggtc ccaccttggg
     2881 gtcgggcatc tcaccgacgg tcagccggga gttgtcgtcg gcataggtgt cgtaggtgac
     2941 ggcacgcatg aactctgccc cttcgtacga gtgactgccg tggggtgcca cggcgttcct
     3001 cccgcaccgt acgcccgccc gcgcccccgt ggcgatcttg tgcccggggc gggccgacac
     3061 cacgtcagcc cgccccgggc gccacgcgct gtcagcgcca cgccacccgg gacgccgctc
     3121 tcggcgctcc tcgctcccgc actccggcag gcgtggcccc tggggccgtt cccgtcagcc
     3181 ctgcttcggc ccggcctgct ggacgacctc gaaggaccac agggtggagc cggaggcggc
     3241 gggcttgtgc tgctgcccgc ccccgccttg gtgggccgcc ttcatcggcc cttccatcca
     3301 cgcctggaac gcctcctcgt cacgccagcg ggtgtagacg aggtactggt cggtgccctc
     3361 cagcgggcgc agcagctcga accactcgaa gccgtcggag ttctccacgg aaccggcacg
     3421 agcgccgaac cgctgctcca gcacctcccg ctgctcatcc ggaacggtca gcacgttgat
     3481 cttcacgatg ctcatgcccc catcctgccg taccgcgtcc gggggccgcc gcatgcccgt
     3541 ggaccggggt caagcggagg ccgggcgtcc gcctgagccc ggaccaggtg gcgactgcgg
     3601 ggagtccggg gtgccgctgg gcggggtgaa ggtcaccggg gtggtgaagg cggcgcggtg
     3661 ggtggcgcgg cgcagggcgc gcagcagggt ggggccggtg gtgagggtga gcacgacggt
     3721 cagcgcggcc cggggcaggt cccagcccag tgaggtggcc agccagtagg cggtgaagcg
     3781 ggccaggttc gcggccaccg ggtcgccggg cacgaaggag atggcggtgc cgagcccacc
     3841 gaggtagggc cacccctgga ggttcatcac gattccgtac gcgacggcgg cgggggcgcc
     3901 gtaggcggcc aggagcagca gttcgcggcg gccgcgcagg cggtggggcc ggggcagcag
     3961 tccggcgccc atggtcaccc agccgagcgc gagcatctgg aacggcagcc aggggccgac
     4021 gcccgccgtc agcagcgcgg aggcgaacat cgtcaccgcg cccaggacga atccgaagcc
     4081 gggtcccagg acgcgtccgg cgagcaccat gaggaagaac atcggttcca gcccggccgt
     4141 gcccgccccg agcgggcgca gtgccgcacc ggctgcggcg aggacgccga gcatggcgat
     4201 ggccttggcg tccaggccgg agtcggcgat ggtggccacg acgacggcga gcaggagggg
     4261 cagcagcgcg gcgaacagcc agggcgcgtc gttggagtgg gcgagcccgg aggcggagtc
     4321 ggccagcagc ggccagccga acgcggcgat gccgacggcc gagaccagcg ccagcgcgag
     4381 ggtggagcgg cggccgaggc gcaccggccg ggtgcgggag gagtccgggg ccaccgtcat
     4441 gacgtggctc ccagcgcccg gcgcacctgt ggcacggtca gccacggctg tggcgcgagc
     4501 accttcgccg tctggggcgc gaacgcgggg gaggagacga cgacgtcggc ggtggggccg
     4561 tccgcgacga cctcaccctg cgccatgacc agcacgcggt cggccagttc ggccgccagc
     4621 tccacgtcgt gtgtggccag cacgatggcg tggccgcgcg ccgccaggtc gtgcagcacc
     4681 tcggtgaggc ggtgtttggc cgcgtagtcc aggccgcgcg tcggctcgtc gagcaggatc
     4741 agcgggggcg cggcggtgag caccacggcc agggccagca ccagccgctg gccctcggac
     4801 aggtcgcgcg ggtggacgtc gtcggccacg ccgggcagca gctcgccgac cagggcccgg
     4861 caggtgccgc ggtcggcacc ggcgtcgcgg tcggctgcgg cgcactcggc ggctacggtg
     4921 tcggcggcca gcaggtcgcg tgggtcctgc ggcaccaggc ccacgtggcg cagcagctgg
     4981 ccgggtttgg tgcggtgcgg ggtgtggccg ccgacgcgga cgctgccgtg ggccggtgcg
     5041 tgcagtccga ccagcgtgtt cagcagggtt gacttgcccg cgccgttgcg gcccatgagc
     5101 gccacggtct cgcccgcctg gacggtcagg ctgacccggt gcaggacgcc ggtgcggccc
     5161 cggcgcacgt cgagtgtggt cacctgggcc agcggcgcgg gctcggccgg ccgggttgcg
     5221 gccccccggg cctcgtcggc cggtgacgcg gcgtccgggc gcggccgggg cggctgcggt
     5281 gtggcgggcg cgagccgttc gcgcagcggg cccgcgcggc gccgggcgtc gcgcaccgac
     5341 agcggcggcg gcgaccaccc ggccagctcg ccgagctgca ccaccggcgg ccgtacgggg
     5401 gagtgggcga gcagttcggc cgggtcgccg agctgggcgg gcgcgccgcg ctcgggtagc
     5461 agcagcacct ggtcggcgta ctggacgacg cgctccagcc ggtgttcggc catcagtacg
     5521 gtggtgccga ggtcgtgcac gagtcgttgc agcaccgcca gtacctcttc ggcggcgccc
     5581 gggtcgagcg cggaggtcgg ctcgtcgagt accaggacgc gcgggtgggt ggtgagcacc
     5641 gagccgatcg cgacccgctg ctgctggccg ccggagagcg tgccgatggg gcggtcgcgc
     5701 agttcggcca ggcccagcag gtcgagggtc tcctccaccc ggcggcgcat ggtggccggg
     5761 ggcaggccga tggactccat gccgtaggcg agttcgtcct ccacggtgtc ggtgacgaag
     5821 tgggcgcgcg ggtcttggcc caccgtgccc accacgtcgg ccagttcgcg cggcttgtgg
     5881 gtgcgggtgt cgcgcccgtc aacggtcacc cggccgtgca gggtgccgcc ggtgaagtgc
     5941 ggtaccaggc cgcagacggc gttcagcagc gttgacttgc ccaccccgga cgggccgatg
     6001 agcaggacca gttcgccctc gggcacggtg aagtcgagcc cgcggacggc cggggtggcg
     6061 gcgtcggcgt acgtgacctg gacgttctcg aagcggatca cggttgcggc ctccttggcg
     6121 cgcggacgga tgcgggcgcg gtccggcggg acggctgggg cggctgggac ggctgggacg
     6181 gctgggacgg ctggggcggc gcatcggcct gccgcctggc gcgcaccccg ccgcgcggcc
     6241 cttcctgccg tgctgcgggc ggtgcctcgt ccggggtgtc cggcgtccgc gagcggcccc
     6301 ggtccccgcg cgcaccgggc agcggcgcga cgagggcggg cagcaggccc agcaggcagg
     6361 ccgcgacggc gcccggcggc aggacgggcg cggtgagcgg gacggcgggc gggcgcagcg
     6421 cgaccggatc gctcacggcg acggccagca ccccggcggc caccgcgagc ccggagccgg
     6481 acaccagcca ggcgcgcacg ccccaccggt ccggccggta ccgggtgcgt accgtgcgcc
     6541 gaccgcccag ccgtagcccc accagcgcga gcagcacgcc cgcgccgagc accggcagcc
     6601 cgaacgccgt gccgtcctcg gtcagcagcc cgtacgtccc ggcgcacacc ccgagcaggc
     6661 cgcccagcgt gcacgcggtg gtggcatgcc gcacggcgcg cggtaccggc gcggtgcgtc
     6721 cgtaaccgcg cgcgtccatg gcggcggcca gcgccaccga ccgctccagc gcaccttcca
     6781 gcacgggcag cgcgacctgg gcgaaggacc gcaggccccg gtccgggcgg ccccgcagtc
     6841 gccgcgccgc ccgcagccgc agcacgtcag cgacgaggtt cggcgcgaag gtgacggcga
     6901 cgacaacggc caccccgacc tcgtacagcg ctcccggcag cgacttcagc agccgcgccg
     6961 ggctcgccag cgcgttcgcc gcgccgatgc agatcagcag ggtggccagg cgcagggcgt
     7021 cgcacagcac gaagtacagc gcttcggcgc tcacccggcc gcccagccgc acgccctgcg
     7081 cccagccggg cagcggcacc tcgggcaggg tgaacagcac ggtggcgccg ggcacgggcg
     7141 agccgagcac caccgcgaac agcaggcgca gcaccaggac cagcaggccc aggcgcagga
     7201 agacgccgta ggagcgggcc cagggcgcgt ccgtgcgccg ggccgccacc acgtatccgg
     7261 cgacggccac cagcagcagg agcagcagcg ggttggtggt gcgggacgcg gcggtggcca
     7321 ggccgagtgc ccacagccac caggccccgg cgtgcagcgc ggtgaaccgg tccgccagcg
     7381 gggcccgcag ggcggcgagc ggacccggcg tcatgagcgg cggcgccgga cctgccaccc
     7441 ggccgcaccc gccagcagca cgacggccac caccccggcc acggtcccga acgtgctcac
     7501 tcccgcgtcc ccggcgtcgt cctcggtggc gtcttcgcct gcggcctcgg cctcccgggt
     7561 ggtgtccgcg gcaccggagc cctccccgcc cgagccctcg tcagccgaga cctgctcacc
     7621 gcagcccgtc tcggggtagc cggagatcgc gcacagcagc gcggaggagt cgtagcgcag
     7681 gggcttggcg gtcgcggcca gcgcctcggc ggcggtgccg tccgccggga cgcgggcgca
     7741 cgcccgcatc ggctccggcg gccgctcgcc gggcggcgcg tcccccgccg tcccggggtc
     7801 gatgacgagc gccacgcgct tgtggccctc gcgcggcgcg gtgtcggcgc agacgtcggc
     7861 gaagtcggcc tcctgacgcg gccggtcggc ctcggcggag ttctcactga cggcgaaccg
     7921 gaagcccagc acggcaccgt cggcgggccg cagcgtgccc gggccctcgg tggcgtagga
     7981 ccaggcggcg ccctcggggc ggtccgcgtc ccaggtccag aacacccagt accggtaccc
     8041 ctcggcctgc gcgggcgcgg cgcccagcac gagcagcagc gtgccgagcg ccacagcgca
     8101 cgcggtgcgc gccgccgcac gcatcagtgg tcgctcccgg tgccggaggc cgggttcgcc
     8161 gagtcggccg tgtcaccgga cccggagttc ttgcggcgcg cgaacacacc ggtggcgaag
     8221 agcgcgccgc cgatcgccgc ggccacccca atccacagcg cggcgtcaaa gccgtcctcg
     8281 gagccgtccc cggccccctc cttctcctgc tcctgcggct ccccctcctg gggcgccggg
     8341 ccggtcgcgg cgagctgggc gaccaggtcg gtgccgccga acgcggtcgg gtcaccgccc
     8401 gcggcgcgca ccgccagcac cagctgggcc agcgcggccg ggctctcctg gacgccgggc
     8461 cattcggtgt ggtgctccgc cagccaggcc aggggctgct cgacgtcgta gccacccccg
     8521 gcgagcgtca gcaccgccag cgtggtggtg ccgtagtcgg gctggtcctc ggcgccgggc
     8581 agggcggaca tcaggtggcc gtcgtgcgcg gccagctggg tgtgcaggta ggccgcgccc
     8641 gcctgcgcgg cgtcttcccg ggcgaacgcg tcgccgtcgg tgcaggcggg cagttcgggc
     8701 gccgcgtcac cggccgagtc ggcggcgacg gccaggccgg actcctgggc ggcgagcgcg
     8761 gcggcggcgg tggccagcgc gttcggcgcc agctttccgt cctcgccggg ctggtaggcg
     8821 aacgcgccgc gctcctcctc gggcgcctcg cagccgagct ggaagccgcg cagggcgtcg
     8881 tgggtggccg cctggggctt ctccccggcg gcgagcagcg cgcccatgac gacggcggtg
     8941 gagttggcgt ccgacgcgcc gccggggttg tagccccagc cgccgtcgtc gttgcgtacg
     9001 gactgaagcc actggacggc ctcgcccacc ggctcgtcgt cctcgcccgc gacggcggcc
     9061 agcgcctgca cggccagcgc ggtggcgttg gtgtcgcgca cggtggtgtc gtcgcacgcc
     9121 tggccggggt cggggcggta ggcggtgaag gcgccgtcat cgcactgctg gccggtcagc
     9181 cagctcacgg ccgcctcggc cggggtgacg ccgacggcgt cctgggcgag cagcgcgtgg
     9241 gcgtggcgga agacgccgtc gtactggggg tcggcggtgc cgtacagctc ctcgggcagc
     9301 gacgcccccg gggtggggga gggcgagtcg tccgccaggg cgaggggtgc cgcggacgcg
     9361 cacaggacgg tggacgcggc cagggccacg gcgcagcggc ggaggaacat cacggtgcct
     9421 ttcggtgaac ggggccgcgt cagccgtcac cgcgcgcgcc gcgccggagc gcgggcactg
     9481 acgggctcgg catccgcaga cctcgacggt gccgtcggcc cactcgggcc gccgggagcc
     9541 tgccctcccc acggggaggg cgtaccgcca cggccaggtg ttccggctcg cgcccgcccg
     9601 acggcacggc gtcggtgcgg cacgctcacg gttgcgggtc agcgccggag tctcaccggc
     9661 ttcccccggc cagggcgggt gctgcaccgg acactctaac ggcggagcgc tcaccgcccg
     9721 gcgtgcgcct ggtcacgcac cgccgtccac cacgtgcggt aacgccttcc gcacggcttg
     9781 tcactgatcc tttcgtgtga cctacgggtg tgcattcctc acacctcctt cgtgacacgc
     9841 gtgactactc ggtcacccac cggcatggaa atctcggtgt cacgccggat cgacgatccg
     9901 cggcaggcgg gccgatcgtc cgcacccacc ggaccggtag gccgtcccag cggcggaccg
     9961 caccgcgaca cccggcgccc gcaaccaccg aggggggacg atggacagcc ggtacgaggc
    10021 gtactgcctg gcggacggcc gcttctacga gacccctgac cggctctcca ccggctccgg
    10081 caaccgcgac ggcggtctgg agaccgctcg ccgccccgtc ccgtccggct ggcgccacgc
    10141 ccgccacggc gactggctcg aactgcgccc gcaagacggt gccttccccg cccagggctg
    10201 gaagatccac gtgtccgcca cgctggcgaa cgccgacgcc gtggccgccc gggtctggga
    10261 ctactgcgtg ccgcgcggca tccccttcaa gttcgtgccc gacctgcacc tgctgcacct
    10321 gcgcaacgcg aagtacgcca gccgcgccac ctccggcaag gccgtcaccg tctacccggt
    10381 ggacgaggag cagctgcaca ccgtgctgcg cgaactggac gcgcgactgg cgggtgaacc
    10441 cggcccgtac atcctcaccg acctgcgctg gaaccagggc ccgctctacg tccgctacgg
    10501 cggcttcgcg ccccgcacct gcgtgaacga gcacggccag ctggtgcccg cgatcgagga
    10561 cgccggcggc acgctgatac ccgaccgcaa ggacccggtg ttcaccgtcc cggcgtgggt
    10621 gacgctgccg ccgttcctcc agccgcacct ggacgcccgc aacgcctcct ccgtcgccgg
    10681 cctgccctac accatcgagc gcgcgctgca cttctccaac ggcggcggcg tctacgcggg
    10741 caaggacacc cgcaccggcg aggacgtcgt gctcaaggag ggcaggccgc acgccggtct
    10801 cgcggccgac ggcgccgacg ccgtacgccg cctggagcgc gagaaggccg cgctggaccg
    10861 gctggcgggc accggcgtcg cccccggggt ccgcgactgg ttcaccctcg aaggccaccg
    10921 cttcctggtc atggactacc tgcccgggca gccgctcaac cacttctacg cccagcgcca
    10981 cccgctgctc gctggcgacc ccgatccgcg cgccgtggcc gactacaccc agtgggcgct
    11041 ggccatccac caggcggtgg ccgaggcggt ggccgccgtc cacgcacgcg gactggtctt
    11101 caacgacctg cacatgttca acatcatggt cgcgccggac gagaagtcgg tgtccctgct
    11161 ggacttcgag gccgccgccc ccgccgctga cgacccccgg cagatcgtcg cccaccccgg
    11221 cttcgtcgcc cccggtgacc gccgtggcta cgccatcgac acctacgcgc tcgcctgtct
    11281 gcggctggcc ctgttcctgc cggtcaccac actgctcgcg gtggaccgcc gcaaggcgtc
    11341 ccacctcgcg gcggtgatcg ccgaacagtt cccggacgtt cctggggagt tcctgggcga
    11401 ggccgtcgcc gagatcgagg gacggcggcc agcccccggc ccacaggacg gcacgggcag
    11461 cacgggcacc ccggacgacg ccgggaacac ggccgcgacg aggactccgg cgcgggaggc
    11521 gaacccgcct ggccccgcgc agcacccggc cccgcacccg gccgaccccg aaccccacgt
    11581 cgcccccgcc gactggccgc gcagccggga cgcgatggtc cgcgcgatcc tcgcctccgc
    11641 cacacccgag cgcgacgacc gcctcttccc cggcgacatc gcccagttca ccgaaggcgg
    11701 cggactcggc ctcgcctacg gagccgcggg ggtgctgtac gcgctggccg agaccggcgc
    11761 cccgcgctac gaacgcggcg agcagtggct gctggaccac accggccagc tcccgccgcg
    11821 caccccgctc ggcctctaca ccggcctgct cggcgtcgcc ctgctgctgg accggctcgg
    11881 ccacaccgag cgcgccgccc ggctcgtcga acaggtactg gccgaacgct ggcagcacct
    11941 gggccacgac ctcgaaggcg gcctggccgg agtcggcctg gccctggacc acctgggcga
    12001 gcgcaccggc gacaccgccc tgcacgacgc cgccggacag gcacttcacc gcgccgccga
    12061 cgccgtggcc caggccaccg cagccgatgg ccgcatcccc cgcgctggcc tgctgcacgg
    12121 cgccaccggc accgccctgc tcgccctgcg ccgctacgaa cgcaccggcg agagcgccct
    12181 gctggaggtg gccgccgacg ccctgcgccg cgacctggcc cgctgcgtcc ccgaccagca
    12241 cggcgccctg cacgtggacg agggcgcgcg caccatgccc tacctcggcg cgggcagcgt
    12301 cggcatcgcc gccgtcctgg acgactacct ccgccaccgg cccggccagg aggcgttcga
    12361 ggaagcccgg cgcgcgatcc tgcccgccgc ccgctcccgg ttctacgccc agcctggcct
    12421 cttccgcggc cgcgccggga tggtgtggca tctcgcccgc accaccaccc ccggcgccac
    12481 cccggccgat ctggcgcggc agctggacgg gctgagctgg tacggcatgg cgcacggcgg
    12541 cgggctggcc ttccccggcg accagatgat gcgcctgtcc atggacctgt acaccggcac
    12601 agcgggctgc ctgctcgcgg tgggcgccgc ccgccacgac gcgcccgtgc gactgccgtt
    12661 cctcccgccg ctcacgcggc ccgagccggc cgcaccaccg cagcgcgcgg cgcggcccca
    12721 ctagacctgc cccggccagg ggtcaggaag caaaccccgt ccctacatga aaggaaagag
    12781 aacatggcgc ttctcgacct gcagaagatg gagaccccgg acaacggcta cggcgacgtt
    12841 ggcagcaacg tcagcctgct gatctgcgac aagcacagcg gtgccagcac catcctgtgc
    12901 ctctgaccgc agccggtcat ccagggtccg ctgacgtgac cgcctgaggc cacgtcaccg
    12961 caggcccggt cccgggcggc ggcccaaacc cgcccgggac cgtcccaccg ggtcccccgc
    13021 gccccgtgcg cgggagaccc ggtgccggcg cgtggcaggc cgcccgcgcc gaaaccgggg
    13081 gagacggcag gaaccgaggg aagcgaggtg cacgcaagag atgacccccg ccgaccgcct
    13141 cctgttcgac gccctccgcc gcagcgcccc ccgcgccacc gccatcgggt gcgtcaccac
    13201 cgcggacgcc gccaccgcgc tggcgctgcc cgccgtgctc ggccgcaccc tcgatctcct
    13261 cctcaccggt gaaccggcca ccggatggct ggcgtgcagc gccgcgctgc tcgccgcgct
    13321 gttcctgctc gacgccgccg agaccgtcct caccggcacc accaccgccc acgcgaccgc
    13381 acgcctgcgc acccgcctgg tgggccacct gctcgccgcc ggcccggccg gagccgcccg
    13441 gttcagccgt ggcgacctgg tcacccgggg caccgcgctc gccgcccagg ccggtaccgc
    13501 gcccgcgtcc gccgccgcgc tgctgtccgc gctcgcgctg cccgtcggcg gcatcaccgc
    13561 gctcctgctc atcgacgtcc ggctcgccgc cgtcttcctg ctcggcgcgc ccctcctggt
    13621 cctgctgctg cgcgccttcg cccgctcctc cggtgacgcc gtcgcccgct accagcaggc
    13681 gcagggcctg atcgccggac ggctggccga agcgctcgcc ggtgcccgca ccgtcgccgc
    13741 cgccgggacg ctggagcgtg aacgcgcccg tatcctcggc ccgctgcccc agctgagccg
    13801 cgaggggcac cgcatgtggc gggtgcaggg ccgggccacc gcgcaggccg ccgtgctggt
    13861 accgcttctc cagctggccg tcgtcgccac ggccggatgg ctgctcgccg acggtcagct
    13921 caccgtcggc gccctgctcg ccgccgcccg ctacgccgtg ctcgccagcg gcatcggtgt
    13981 gctgacgggc cgcgtcgccg cgctggtccg tgcccgccag gcagccgtcc ggctcgccga
    14041 ggtgcacgcc gtccccgccg tgccctacgg caccgccccg ctcccggacg gccccgggac
    14101 gctggagctg cgcggcgtca gcgcggtgcg cgacggacgc acggtgctgt ccggggtgga
    14161 cctcacggtg cccggcggag ccaccgtcgc cgtcgtcggc cgctccggtt ccggcaagtc
    14221 cgaactggcc cggctggcgg gcaagctggc cgagccgagc acgggcaccg tactgctcga
    14281 cgggctcccg ctggacacgg tggacgccgc ctccctgcgc gccgccgtcg gctacgcctt
    14341 cgagcggccc gccctggtcg gcggcaccct cgccgggacg atcggactcg gccccgcccc
    14401 gcccggccat gccgtcgtcc tggccgccgc ccgcgccgcc cgcgccgact ccttcatccg
    14461 caccctgccc gagggctacg ccaccccctg cgccgacgca cccctgtccg gcggcgaggt
    14521 gcaacgcctg gggctggccc gcgccttcgc ccacgcggga cgcctgctca tcctggacga
    14581 cgccacctcc agcctggaca ccagcaccga acgccaggtc accgccgtgc tgttcgcccc
    14641 cgagcgcacc cgcacccggc tcgtcgtcgc ccaccgtgcc accaccgccg cccgcgccga
    14701 tctggtcgcc tggctcgacg cgggccacct gcgcgccctg gccccgcacg cccgcctgtg
    14761 gcacgacccg gcctaccgcg cggtgttcac cgccccggac gcggctccag acgcggcggc
    14821 ggccccgggc gcggacacca cgcgccccgc cgacgcgggc acccccgccc ccaccgccgc
    14881 cgggaccgcc gacgccgctc ccgggaccgc cggcatcgca gtcgaggccg ccgatgcgtg
    14941 aggccacccg caccaccacc aaggagcccg gcacccgggg cctgttcgcg gcgggggcgc
    15001 ggcgcctgcg gcagcggccc cgcgcgctcg gggcactcgc cgggtggtcg gtgctggagt
    15061 ccgcgcagac gttcctgctc ggcctggccg tcgcacacgc gctggacgac ggcttcctgc
    15121 gcggcagcgt cggcaccgga ctggcgtggc tggcgctcgg cgcgctcggc gtgctcgccg
    15181 gttccttcgg cgccggacgg gtgtaccggg cggtcgccac gctcgctgag ccgatgcgcg
    15241 acctgctggt cgagcgtgtc gtcggcaccg ggctgcacgc cgccgtccgc cggggccggg
    15301 cgaccgactc gggtgtcgtc tcccgtctga cgcaccaggt cgagatcgcc cgggacagct
    15361 tcgccgggct gctcatggcg ggccgcgcct tcgccttcac ctccgccgcc gcgctggccg
    15421 gactcgcctc cctgcacccg ctgctgctcc tggtggtgct gcccccgctg gccctcggcc
    15481 tgctggtctt cggactctcg ctgcgcccgc tggcccgccg ccagcgggac ttcctcatcg
    15541 ccgacgaggc catcgccgag cacctgggcg agacggcggg cgggctgcgc gacgtggtgg
    15601 ccgccggggc ggaggagcct acgcggacgg aggccgccgc gcgcgtcgcc gccgagcggc
    15661 gggccgccga ggcgctggcc cgctggggcg tcacccgggc ggcggccctg gggatcggcg
    15721 gacggctgcc ggtggtgctg ctgctcgtcc tcacgccgtg gctgctggcc cgtggggtga
    15781 gcgcgggcgc gctcgccggg gcgctgacct acctgctgca ctcgctgatc cccgcgctgg
    15841 agagcctggt gcacgggctg ggcaacgcgg gcgcgcggct ggccgtcgtc gtcggcaggc
    15901 tgcgcggtgc cgacgacgcc ccgccgaccg cgccgcccgc gccccccgcg ccgccgaccc
    15961 cgcgcacgcc cggtaccgcg ctcagcctgc gcggcgtcac cttcgcctac gggcggcgcg
    16021 cgcagccggt gctcgacggg gtgaacctgt gcctgccgcg cgggggccac ctggccgtgg
    16081 tcggcaccag cggcaccggc aagtccacgc tcgcgctgct cctcgccggg ctgctgacgc
    16141 cggacgccgg tcacctcgcc gtacgcgggc cggtggcgct ggtcccgcag gaggcgtacg
    16201 tcttcaccgg cacgctgcgc gccaacctca cctacctgtg cccggacccg gtgcccgacg
    16261 ccgcgctgca ccgggcgctg gaggccaccg gtggcgccga tctggccggg cggctgggcg
    16321 ggctggacgc cgacgtcgat ccggagcggc tgtcggcggg ggagcggcag cggctggcgc
    16381 tggcgcgggc gtacgcggca ccggcgtcgc tggtcgtgct ggacgaggcc acctgccatc
    16441 tggacccggc cgccgaggca cgcgcggagc aggcgttccg gcggcggccc ggcaccctgg
    16501 tggtgatcgc gcaccggatc agctccgccc ggcgcgccga cctcgtgctg gtgctggacg
    16561 gcgcccgctc gcggtgcggc accccggggg aggtggcgtc cgcctccgcg cgctaccgcg
    16621 agctggcggg cgcctgggag gcggcggtgc cggacgcggc ggacgcgtcc ggcaccgcaa
    16681 gtgcggcaag caccgcaagc tcacagccag ccggagcgct gggcgataca gatggcgtcc
    16741 acccggttgc gggcgccggt cttccgggtg atcgctgaca tgtagttccg tatcgtgccg
    16801 ttgctcaggt gcagcgaact ggcgatctcc gcgaccgacg cgccctcggc ggccagggac
    16861 agcacgctca gttcacgccg ggtcagcggg agttgggtgg cctggaggaa gccgaaggcc
    16921 agcgaggcat cgacgaaacg ttcccccttg gcgacctgcc gtatcccggc cagcagctcc
    16981 tggggactcg cgtccttgtt gacgtagccc tgcgcgcccg cctccaccgc ctgccgcagt
    17041 gttcccggac gacccggggt agccaggacc aggacccggc aggtcggtgc gggcagctcg
    17101 cggcgcaggg cgtcgaggtc ccgctgttcg cccccggcgc cctcgtccag atcggccacg
    17161 cacacgtccg ccccggccga gcgtgccgcg cggcccgctt gtctccacgg cgcggtgctc
    17221 acgtccatgt cctgtgcctt gctgagcagt tgggccaggc ccgacctcag caggcgcgtg
    17281 tcgtgtacga gcaagacccg gatcactgac gctacctccc gtgcatctcc gcacagccgg
    17341 ccgttcctgc cgcgcggttc gtcgcctacc ccgggtggcc acggcctacg ggatgggtga
    17401 cagcggccat tgaatccgca ccactcggcg acgaccattc aaatcaagcc acgtggaggt
    17461 acggaagcgc gcacgccgtg tctcaatgcg cctactgtgc gccctcggag gtctcgcggt
    17521 tcgccgggtg tgcttccgcc aggcgacaca ccgtcttcag gtccgtaccc acggtttcga
    17581 tggtcgtccg cccggacagc cagctgatga gcagggagaa ccaggtgtgc tcgatgaccc
    17641 ggacggcgga gagctgtgcg ggtgtgggcg caccgcccgc tttcatcgcg tccagcacga
    17701 tcccgctggt gatctccagg acggtatcca cctcggcgcg caccgaccga tccgccgaag
    17761 tcagcgcccg caccatggcg gaggccaggt gtggctcgtc ccgcatggcg tgaaatgcgc
    17821 gcatcagcgt ctccgccacc cgcgcccccg cacccggtcc gtgcggtggg tccgcgtcca
    17881 gggttccgtg cagcagccgc aactggtcct gaaggacggc caccagcagg tgaatcttcg
    17941 acggaaaata gcggtacagc gtgccgagtg ccaccccggc agactcggcg acctcgcgca
    18001 tctgcacggc ctcgaaacca cccccacggg cgagatcggt agcggcccgc aagatgccct
    18061 gccgccgcgc ccgctgttgg cccgagcgtc cccggcgcgg ggcgtgcggc acgtcggcgc
    18121 ccgtggtgtg cccggcgccc ggtgcgggtc cggcagccgc gcccggagcg cccgagcgcc
    18181 cggtccccgc ccgcgccgtc ctcgcgggcg gtgtggctgc cccggctgtc cccgccgacg
    18241 cgtgcggtgg cgcggcgggt gtgggcgagg tggcccggtg cgggccgggc ggtggcgtgg
    18301 cgggtgagct catggtgtcg tcaggtggcc gtatttctgt gctggtcgtc gcgatcgtgc
    18361 gcttgcgtgg tcgccgtgcc gtcccgggca ttttgccgcc ccggccgcgt gctccgggtt
    18421 ccgcgcgtac tcggggcgtc cgggcgatcg gcgcgggccg cgaccgtggt gggaatcacc
    18481 gggtccgctc cgggcggcgt ggtgaccggc cggtagattc aggggcgcgg cgtaccggcc
    18541 gcactccgga gtgaaacttg ttctacctta gcgcgagcgg ttacgctccc gcgaccatcc
    18601 ggcacggaac ccggcacgaa gggacggacg gcgagtgacc gccaaggcca tacgcgacgc
    18661 ggcgtccgca ccccggcacg cccccggccc cggcggcggc cgcccgctgc gcatcgccct
    18721 gctgacctac aagggcaacc ccttctgcgg cggccagggc gtctacgtgc gccacctctc
    18781 ccgcgaactg gcccgcctgg gccaccgcgt cgaggtcatc ggagcccagc cgtaccccgt
    18841 ggtggacgag ggcgtcaccc tcaccgagct gccgagcctg gacctctacc gccagcccga
    18901 cccgttccgc accccgcgcc gcgcggagta ccgcgactgg gtggacgcgc tggaggtcgc
    18961 caccatgtgg accggcggct tccccgagcc gctgacgttc tcgctgcgcg cccgccgcca
    19021 cctcgccgcc cgccgtggcc agttcgacgt cgtccacgac aaccagaccc ttggctacgg
    19081 cctgctcggc ggcccgcccg tgctcggcgc accgctggtc accaccatcc accaccccat
    19141 caccgtggac cggcagctcg acctcgccgc cgccgacacc ctcaggcgtc gcctgtccgt
    19201 gcgccgctgg tacggcttca cccgcatgca gcgccgcgtc gcccgccgcc tgccctccgt
    19261 cctcaccgtc tccggcacct cgcgccagga gatcgtggac cacctcggcg tgcgtggcga
    19321 ccgcgtccac gtcgtccaca tcggcgccga caccgacctg ttcacccccg acccggccgt
    19381 gccgcaggtc cccggacgca tcgtcaccac ctccagcgcc gacgtgccgc tcaaggggct
    19441 ggtgtacctg gtggaggcgc tggccaaggt ccgcaccgaa cagcccgacg cgcacctggt
    19501 cgtcgtcggc cgccgcgcgg acgacggccc cgtcgccgcc gccatcgaac gcttcggcct
    19561 gcacgcgccc gaccgcaccg gccgccgccc cgtcgagttc gtcaagggca tcaccgaccg
    19621 cgaactcgcc gacctggtgc gcggcgcgca gctcgcctgc gtcccctccc tctacgaggg
    19681 cttctcgctg cccgccgccg aggccatggc caccggcaca ccgctgatcg ccaccaccgg
    19741 cggcgccctg cccgaggtcg ccggacccga cggtgagacc tgcctcgcgg tgccgcccgg
    19801 cgaccccggc gccctcgccg gcgccctcgc ccgcctgctc gccgacgccc cgctgcgcgc
    19861 ccgcctcggc gccgccggac gcgcccgcgt actcagccgc ttcacctggc ggcaggcggc
    19921 cctcggcacc gccgcgcact accgcgaggc catcgcccgc gctaccgccg cccgttcgcg
    19981 cacctgacca ccgcccgccc gctgacgccc ctcgccacga aagcagaacc cctgtgctga
    20041 ccgtcgactt ctcccggttc ccgctcgccc cgggcgaccg cgtcctcgac ctgggctgcg
    20101 gcgccggacg ccacgccttc gagtgctacc ggcgcggcgc ccaggtggtc gccctggacc
    20161 gcaacgccga ggagatccgt gaggtggcca cctggttcgc ggccatggaa gaggccggcg
    20221 aagccccgcc cggcgccacc gccaccgcga tggagggcga cgcgctggcc ctgcccttcc
    20281 ccgacgacag cttcgacgtc gtcatcatct ccgaggtgat ggagcacatc cccgacgaca
    20341 agggcgtgct cgccgagctg gtgcgggtgc tgcgccccgg tggccgcatc gccgtcaccg
    20401 tcccccgcta cgggccggag aaggtgtgct gggcgctgtc cgacgcctac cacgaggtcg
    20461 agggcggaca catccgcatc taccgggcga ccgaactgct cgcccggctg cgggaggcgg
    20521 gcctgcgccc ctacggcacc caccacgccc acgcgctgca ctcgccctac tggtggctga
    20581 agtgcgcctt cggcgtggac aacgcccagg ccctgccggt ccgcgcctac cacaagctcc
    20641 tggtgtggga catcatgaag aagccgctcg ccacgcgcct ggccgagcgc gcgctcgacc
    20701 cgctgatcgg caagagcttc gtcgcctacg ccaccaagcc gcacctgccc cgcgccgccg
    20761 cctccgccca cgccgccgct gagggcgctg cgtgacgagc ccggagcgca ccgaacgcct
    20821 cgtcctgccc ggcgtcctca ccgccgagca ggcgtcccag accgtcgcgg gcatcctcgc
    20881 gcagcagcgc ccggacggcg ccattccctg gttccgtggc caccacctcg acccgtggga
    20941 ccacgtggaa gccgcgatgg cgctcgacac ggcgggcgaa cacaccgccg ccgaggccgc
    21001 ctaccgctgg ctcgccgacc accagctgcc cgacggctcc tggtacgccg cctacgccga
    21061 cggcgccgcc gacacgccca ccgaccgggg ccgcgagtcc aacttctgcg cctatgtggc
    21121 cgtcggcgtc tggcaccact acctgtccac cggcgacgac accttcctgg accgcgtgtg
    21181 gcccgtcgtc gtcgccgccg tggacttcgt gctggcgctc cagcagccag gcgggcccct
    21241 cgcgtggaag cgggaggacg acggcaccgt acgcaccgag gcgctgctca ccggctgctc
    21301 ctccagctac caggccgtgc gctgcgcgct ggccatcgcc gaacaccgcg aggaaccgca
    21361 gcccgactgg gaactggccg tcggccgcct cggccacgcc atcacccacc accccgagcg
    21421 gttcgccgac aagtcccgct actcgatgga ctggtactac cccgtcctcg ccggagccct
    21481 caccggtccg gccgccaagg cacgcatcga ggagggctgg gaccgcttcg tcgtccccgg
    21541 tctcggcgtc cgctgcgtca cccccaaccc ctgggtgacc ggcggcgaga gcgccgaact
    21601 cgcgctcgcg ctgtggacga tgggagaggc cgaccgcgcg gtggagatcc tgcggtccat
    21661 ggcccacctg cgtgccccga acggcatgta ctggaccggc tacgtcttcg ccgacgacgc
    21721 catctggccc cgcgagcaga ccgcctggac cgccggttcc ctcctcctcg ccacggccgc
    21781 cctgggcggc gacgaggcga ccacggagat cttcactccc gcgaacctcc ctccgggcct
    21841 gcccccggac tgctgcgggt agcacgccac ggggccggcc cgcccggcaa cgcgccgcct
    21901 cctcggccgc gtccggccgg gctcgcgtct ggtcggctct ccgcgccggt tgcgctggca
    21961 cggcgcaaag agccgactcc ccgcgcaaca gaagaccccg gcccccgtga gggagccggg
    22021 gcctggtgcg cccggggcgg cggtcagccg cgctggatgc cggaggtgtc ctggagcagg
    22081 ccgcggcggc catcctgggt ctgggcgatg agcgcctgtc ctcgctgctc gaccgccagg
    22141 taccagacgc ccggtgtcag ctcggccacc ggctggggcg agccgtcctc gccgacgagc
    22201 gggcgcgcgg ccggaaccgc gaaccagaac ggctggaagt tcgggtcggc ctgcggctgg
    22261 gcggcggcgg gctggggcgc ctgggcggcc tgcggggcag cggcggcgtg ggcctgctgc
    22321 ggctgctggc cagcgtaggg ctgctgctcg gcgtacggct gctgcggctg ctgcccgccg
    22381 tagggagcct gcgcgtcata gggcgcctgc gcctcgtgcg gcgcgccggg ctgggggccg
    22441 ttcgggtagc cgtaggacgg ctggccgccc tgcgggtagc cgtacccggg ctgctgcccg
    22501 tacggctgct ggcccgcctt cgggccaccg gccgggatca gcggcgcgcg caggacgggc
    22561 acgaactgcg gcagcacggc cccggccagc agcacgatga gcgcgatgaa ggcgatgatc
    22621 tggcccgcgc cgatgtccag gccctccttg gcggcgctgg cgctgccgaa cagcgtccac
    22681 agggcagtcc agaacgcgaa gacgctcagg gccacgcccc actg
//
