LOCUS       NZ_JAEVFI010000005     10453 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Streptomyces sp. JJ66 scaffold5_size293034, whole genome shotgun
            sequence.
ACCESSION   NZ_JAEVFI010000005
VERSION     NZ_JAEVFI010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. JJ66
  ORGANISM  Streptomyces sp. JJ66
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 293034)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Draft genome of Streptomyces sp. JJ66
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 293034)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2021) Marine Biotechnology and Ecology Division,
            CSIR - Central Salt and Marine Chemicals Research Institute, G.B.
            Marg, Bhavnagar, Gujarat 364002, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2017
            Assembly Method                   :: Velvet v. V 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 320.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019303495.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 03:51:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,515
            CDSs (total)                      :: 4,446
            Genes (coding)                    :: 4,340
            CDSs (with protein)               :: 4,340
            Genes (RNA)                       :: 69
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 31 of 106
            Pseudo Genes (incomplete)         :: 82 of 106
            Pseudo Genes (internal stop)      :: 3 of 106
            Pseudo Genes (multiple problems)  :: 9 of 106
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:22:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 195250
            Orig. end                         :: 205703
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAEVFI010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10453
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10453
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10453
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5453](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5453
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    542..557
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     gene            654..1175
                     /locus_tag="JJV70_RS05645"
                     /old_locus_tag="JJV70_05650"
     CDS             654..1175
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007453627.1"
                     /locus_tag="JJV70_RS05645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05650"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_219046589.1"
                     /transl_table=11
                     /translation="MPEITQLSAADLLRAADALAELLLDVVDGGDSLGFLSPLTHAEAR
                     AWWTSRADALEVGHALLWAAHTGGQLTGTVTLLPAPMPNGRHRADVAKLMVHRAARGRG
                     VARALLDAAERAAADAGLTLLVLDTQSDTAAVDFYRATGWTEAGTIPGYATDTTGTPRP
                     TTYFYKQLAA"
     gene            1172..1933
                     /locus_tag="JJV70_RS05650"
                     /old_locus_tag="JJV70_05655"
     CDS             1172..1933
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020556153.1"
                     /locus_tag="JJV70_RS05650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05655"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_219046590.1"
                     /transl_table=11
                     /translation="MSGALELVAIAAAGVAAGGINAVVGSGTLITFPTLLAFGYPPVLA
                     NVSNNIGLVPGTLSAAYGYRRELRGQRRRLLRFGTGSLLGGLIGSLLLLTLPAETFAAV
                     VPVLILAACVLVLLQPRLNRWLTRRRPHDDGRDGGVPMWLGVLGTGVYGGYFGAAQGVL
                     LMGLFGSFLRDDLQRLNAVKNVLAAIVNGVAAVIFIAVTHVDWAAAGAIAAGATLGGLL
                     GARVGRRLPPTALRAVILVVGVTASVTLLLG"
     gene            complement(1974..2204)
                     /locus_tag="JJV70_RS05655"
                     /old_locus_tag="JJV70_05660"
     CDS             complement(1974..2204)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048929.1"
                     /locus_tag="JJV70_RS05655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05660"
                     /product="hypothetical protein"
                     /protein_id="WP_219046591.1"
                     /transl_table=11
                     /translation="MTADGQPPQTGTAARDTVSNRVGIVMAYEGALAFLRPLLGGREWD
                     ADPAHLVPLSRGELLRAHVAELNARSRKPLR"
     gene            complement(2201..2455)
                     /locus_tag="JJV70_RS05660"
                     /old_locus_tag="JJV70_05665"
     CDS             complement(2201..2455)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152987.1"
                     /locus_tag="JJV70_RS05660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05665"
                     /product="hypothetical protein"
                     /protein_id="WP_219046592.1"
                     /transl_table=11
                     /translation="MAKTSRPDAETAARRAKVKEALTARYALADALRRAGIQLPAMDVR
                     TPWADEREGSARYALIQLGVCSAPVAHLLAEVISRGAER"
     misc_feature    2448..2462
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            2659..3501
                     /locus_tag="JJV70_RS05665"
                     /old_locus_tag="JJV70_05670"
     CDS             2659..3501
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014048931.1"
                     /locus_tag="JJV70_RS05665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05670"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_219046593.1"
                     /transl_table=11
                     /translation="MPQRRVITGRSQNPRQRFAEELRRLRVQRGKSLRQLGEHLGWDWS
                     LFGKMEKGETIGSPEVAEALDQYYGTPGLLLALWELAAGDKSQFRERYQRYMTLEAKAV
                     SLWHFAVSVLPGLLQTPGYAREVLAAGGLKGRELDQQVAARTGRCALLDGTKAPPFRTI
                     LSEAVLRTPLRDPQEWRDQLQHLVTMAERQSVVLQVLPFSVGMHGLVSTALMFLRLPNG
                     RTAAYRESAHQGELIEEDAQVERLQRVYDGMRDLALSPAESLQFVLPFLEEASCEPST"
     gene            3483..3692
                     /locus_tag="JJV70_RS05670"
                     /old_locus_tag="JJV70_05675"
     CDS             3483..3692
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018957019.1"
                     /locus_tag="JJV70_RS05670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05675"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_219046594.1"
                     /transl_table=11
                     /translation="MRAIDLSAVSWRKSSYSNPDGGECVEVAEGLAAVVPVRDSKMPGG
                     PVLVFPTAGWGSFVNAVKSAHPSA"
     gene            3808..4017
                     /locus_tag="JJV70_RS05675"
                     /old_locus_tag="JJV70_05680"
     CDS             3808..4017
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579518.1"
                     /locus_tag="JJV70_RS05675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05680"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_219046595.1"
                     /transl_table=11
                     /translation="MRSIDPSAVSWRKSSYSNPDGGQCVEVAEGLAAVVPVRDSKVPGG
                     PVLVFPAAGWGSFVNAVKSAHPGA"
     misc_feature    4036..4053
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.42"
                     /tool="antismash"
     gene            4248..4817
                     /locus_tag="JJV70_RS05680"
                     /old_locus_tag="JJV70_05685"
     CDS             4248..4817
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823060.1"
                     /locus_tag="JJV70_RS05680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05685"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_219046596.1"
                     /transl_table=11
                     /translation="MLEITGPVKTERLILRAFKAGDEEDAYAFESRADVARYLYNEPRT
                     REEITRLMTERSAQTVLRREGDNIQLAVEGDGTVIGYVLLTWVSERHQQGEFGYVLHPD
                     YHGRGFATEAAVEMLRLGFDRLGLHWITARCDARNTASARVMERLGMRQEAHFIESEWV
                     KGEWTSELHYALLAPEWRASRWASNP"
     gene            5001..5453
                     /locus_tag="JJV70_RS05685"
                     /old_locus_tag="JJV70_05690"
     CDS             5001..5453
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Lactococcin_972"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01653.1"
                     /locus_tag="JJV70_RS05685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05690"
                     /product="lactococcin 972 family bacteriocin"
                     /protein_id="WP_257573429.1"
                     /sec_met_domain="Lactococcin_972 (E-value: 3.9e-15,
                     bitscore: 50.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKKIAIAAATVITAAPGTLVAAEPATAAPEPLISTAPGSQAPPA
                     VLTGPNGEQPTQWGVAVVPVASSRGAMTPLATKKVGGGTWNYGTRAAGLDGSTCYSNYI
                     HPSKKHTATVIKAGYTYKDYANPDVWAKAKITAGAAYTCYTYWGVY"
     gene            complement(6378..6935)
                     /locus_tag="JJV70_RS05690"
                     /old_locus_tag="JJV70_05695"
     CDS             complement(6378..6935)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004980847.1"
                     /locus_tag="JJV70_RS05690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05695"
                     /product="hypothetical protein"
                     /protein_id="WP_257573431.1"
                     /transl_table=11
                     /translation="MTALLLILPLSACGMLGESSENNSTENVPNVNMQEAANRADTVLD
                     MTLKAIKPEVEWVYGETTSQACTDWKNEETETGAVSRRRAVTTIISKERRGNFLGGVED
                     FWKKSGYEIIAVRDSATHPAVYAETPEGFRIRLMFGAKGQALLQASTPCAEQSDVTDPK
                     EDTGPAPAPNAESDFWSASGNS"
     misc_feature    6912..6925
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.28"
                     /tool="antismash"
     misc_feature    complement(6912..6927)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.59"
                     /tool="antismash"
     gene            complement(6947..8761)
                     /locus_tag="JJV70_RS05695"
                     /old_locus_tag="JJV70_05700"
     CDS             complement(6947..8761)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735782.1"
                     /locus_tag="JJV70_RS05695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_05700"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_219046598.1"
                     /transl_table=11
                     /translation="MPSTLTWSELRDLDLSGLHAAASGWAGVRDRAHAARQTLNQRTAA
                     LDDTEEGEATKAAVTRLTTLSENYQYIYTECGLINTALTGLAEELLPHQKAVNNALDDA
                     ESLKFTVGADGAVTYPAKGELLDGSPAPGGTVTASTLLTGEWLVSQPLVPNPLLDPNPN
                     RHEAQDIADRLYRAAKDAREIDDSYAEALSKLTTKPGLDVTDAMWTDAHEDSTAVREAA
                     YGYLDASDIPTDLSAAERKEWWDGLSAGERAQHLTLHPDLIGNLDGIPAAARDEANRTY
                     LPLLMGKLEGEDTEDARTKLAGLVVIEEKLQKGSVPPMYLLGIGDEGNGRAIVSYGNPD
                     TSRNVSAYVPGLGTALDEAFAKNDLERARHTALGAQDHDPSSASIVWLGYDAPQMGTDK
                     VINNAAVMTEIHATAGAPTYNAFIEGLGATNEHTDPHITAIGHSYGSLTVGLAAQRPGG
                     IPGADDIILLGSPGVSAEHASELGVDSDHVYVGAAENDPVTKLPSKAEIDGAIEGFTST
                     NPITAYLWYELADIGDDDIWFGKDPASGAFGANRFAVDDGPRPYIDGEGPMPAHSNYFN
                     PEKDQLSADNVAAIVAGKPEDVISEAPR"
     gene            complement(8765..9241)
                     /locus_tag="JJV70_RS05700"
                     /old_locus_tag="JJV70_05705"
     CDS             complement(8765..9241)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJV70_RS05700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJV70_05705"
                     /product="hypothetical protein"
                     /protein_id="WP_219046599.1"
                     /transl_table=11
                     /translation="MSPDATPEVWQQLFALAEQRPPSASPASSPDGTSPSPLLALASAD
                     GGAPEGGKLRHSAGPWTSASNSVDGMANVLAQAKNKLETSHENIAAEGAGLASVSKLTK
                     VRETWVERLESAREECENLAPKLRAVAKEHGENEAATTSTFKGAQAPTGAEGGR"
ORIGIN
        1 cggatcgaca gcgccgtcca cacctcgatg cccagcgact cccaggtgtg cagcagcacg
       61 ctgttgcccg aggcacgcac caactcccgg tgaaagccca cggtgtgccg cacctgcgcc
      121 tcgccgtccc cggcccggtc ggcctcgtac agcgccgcca cgtgcggttc cagcgcggag
      181 acgtcgtcgg ccaggcgcgg cgcggccagc tcggcggcca tctgctccag cccggcgcgc
      241 accgggtaga tctcctccag gtcggccgcc gacaaatccc gcacccgcac gcccttgttc
      301 ggcgccgact cgatcagccg cagcgcctcc agctcgcgca gcgcctcccg taccggcgtc
      361 tggctgacct gcaactctac cgcgatgcgc cgctcgacga tgcgctcacc cgggttccag
      421 cgaccgctga cgatcccctc cacgaggtgt tcgcggatct gctcgcgcag cgagtgcacg
      481 acgggcggtg ccatgggagc tcctaactgt caccaccgac tctacggcgc ccggtcctca
      541 cgttactcat cggtcacccg tcgccgcgta gcctccggca gccctcccac ggtccaggcc
      601 gcgcgccctc cccggccctg ccgcccgcgc tggccgtccc gtagggtcgt cccgtgccag
      661 agatcaccca gctgtccgcc gccgatctgc tgcgtgcggc cgacgcactg gccgagctgc
      721 tcctcgacgt cgtggacggg ggcgactccc tcggcttcct gtcgccgctg acccacgccg
      781 aggcccgcgc ctggtggacc tcccgcgcgg acgcgctgga ggtcgggcac gcactgctgt
      841 gggccgccca caccggcggc cagctgaccg gcaccgtgac cctccttccc gcgcctatgc
      901 ccaacggacg ccaccgcgcg gacgtggcca agctcatggt ccaccgcgcc gcccgtgggc
      961 gcggcgtggc gcgcgccctg ctggacgccg ccgagcgggc cgccgccgac gcgggcctca
     1021 ccctgctcgt gctcgacacc cagtccgaca ccgccgccgt ggacttctac cgcgccaccg
     1081 gctggacgga ggccggcacc atccccggct acgccaccga caccacgggc accccgcgtc
     1141 ccaccacgta cttctacaaa cagctcgcgg catgagcggc gcgctggaac tggtggccat
     1201 cgcggcggcc ggggtcgccg cgggcggcat caacgccgtc gtcggctccg gcacgctgat
     1261 cacctttccc acgctcctcg ccttcggcta cccgcccgtg ctggccaacg tctcgaacaa
     1321 catcggcctc gtccccggca cgctcagcgc cgcctacggc taccgccgcg aactgcgcgg
     1381 ccagcgccgc cgcctgctgc gcttcggcac cggctccctg ctcggcggcc tcatcgggtc
     1441 gctgctgctg ctcaccctcc cggcggagac gttcgccgcc gtcgtgccgg tgctgatcct
     1501 ggccgcctgc gtcctcgtcc tcctccagcc gcgcctgaac cgctggctca cccgccgccg
     1561 cccgcacgac gacggccgcg acggcggggt gcccatgtgg ctcggcgtgc tcggcaccgg
     1621 cgtgtacggc ggctacttcg gcgccgccca aggcgtgctg ctcatgggcc tgttcggcag
     1681 cttcctgcgc gacgacctgc aacgcctcaa cgccgtcaag aacgtgctcg ccgccatcgt
     1741 caacggggtc gccgccgtca tcttcatcgc cgtcacccac gtggactggg ccgccgccgg
     1801 ggccatcgcc gccggggcca cgctcggcgg cctcctcggc gcccgcgtcg gccgccgcct
     1861 gccgcccacc gcgctgcgcg ccgtcatcct cgttgtcggc gtcaccgcct cggtgacgct
     1921 gctgctcggc tgacggcgat gctgggctga cggtgctgcc gagctgacgc cgctcagcgc
     1981 agcggcttgc ggctgcgcgc gttgagctcc gccacgtggg cgcgcagcag ctcaccccgg
     2041 ctcaggggca ccaggtgggc cgggtcggcg tcccactccc ggccgcccag cagggggcgc
     2101 aggaaggcga gggctccctc gtaggccatc acgatgccca cccggttgga cacggtgtcc
     2161 cgcgcggcgg tgccggtctg cggcggctgg ccgtccgccg tcaccgttcg gctccccgcg
     2221 agatgacctc agccagcagg tgggcgacgg gggccgagca caccccgagc tggatcagcg
     2281 cgtaccgcgc cgagccctcg cgctcgtcgg cccacggcgt gcggacgtcc atcgccggaa
     2341 gctggatgcc cgcccgccgc agcgcgtcgg ccagggcgta gcgggcggtc agcgcctctt
     2401 tcaccttggc gcggcgggcg gcggtttcgg cgtcgggccg tgaagtcttc gccatctgcg
     2461 attcctttca tatgacttat gcacatttgt ctggcacatt cgccccaccg gaaatacggt
     2521 gggtagcacg ggcattacga gaatggggcc tgaggagggc tgacggggcg tcacgggggc
     2581 ttggcttccc gcctcgacgc actgtttcca caccttccac gggctgtgac cacacgtcct
     2641 caacggagag gaacactcat gccgcagcgt cgcgttatca ccgggcggag ccagaacccg
     2701 cgccaacggt tcgccgagga gctgcgcagg ctccgcgtgc agcggggcaa gagtctgcgc
     2761 cagctcggcg aacacctcgg ctgggactgg tcgttgttcg gcaagatgga gaagggagag
     2821 accatcggca gccccgaggt agccgaggcg ctggaccagt actacggcac ccccggcctg
     2881 ctcctggccc tgtgggagct ggccgccggg gacaagagcc agttccgcga gcgctaccag
     2941 cggtacatga cgctggaggc caaggcggtc agcctgtggc acttcgccgt cagcgtcctg
     3001 cccggtctgc tgcaaacccc cggctacgcc cgcgaagtcc tggccgccgg agggctcaag
     3061 ggccgcgagc tggaccagca agtcgccgcc cgcaccggcc ggtgcgccct gctggacggc
     3121 accaaggccc cgccgttccg cacgatcctc tccgaagcgg tcctgcgcac cccgctgcgc
     3181 gacccgcagg agtggcgcga ccaactccag cacctcgtca cgatggcgga gcgccagagc
     3241 gtggtgctcc aggtgttgcc gttctcggtg ggcatgcacg ggctggtcag cacagccctc
     3301 atgttcctgc ggcttccgaa cgggcggacg gcggcctacc gggagagcgc tcatcagggc
     3361 gaactcatcg aggaagacgc ccaagtcgag cgcttgcagc gtgtatacga tggcatgcgc
     3421 gacttggcgc tctctccggc cgagtccttg cagttcgtcc tgcccttctt ggaggaagcc
     3481 tcgtgcgagc catcgacctg agcgccgtgt cctggcgtaa gagcagctac agcaaccccg
     3541 acgggggcga gtgtgttgag gtcgccgagg gccttgccgc cgtggtgccg gtgcgggaca
     3601 gcaagatgcc cggtgggccg gtgctggtgt ttcccactgc gggttggggt tccttcgtca
     3661 atgcggtgaa gtccgctcac ccgagcgcct gacgggcaag ctgccgcaag gcccctgaga
     3721 ccacccggtc ttgggggcct tgcgctgccc ggctgccccg tgcctcacta atcagtggag
     3781 cccgcgtctc acctcggagg agtccccgtg cgatccatcg acccgagtgc cgtgtcctgg
     3841 cgtaagagca gctacagcaa ccccgacggg ggccagtgtg tggaggtcgc cgagggcctt
     3901 gccgccgtgg tgccggtgcg ggacagcaag gtgcccggtg ggccggtgct ggtgtttccc
     3961 gctgcggggt ggggctcctt cgtcaacgcg gtgaagtccg ctcacccggg tgcctgaccg
     4021 tagtcacaac tccggcgtgc ggtagagcgg atatgccgta cccaggtcgg gaatctccag
     4081 caccggtacc gggcttccct cccagtcccc gctggcccgg gactctccag cgcacggaga
     4141 cccggatatc ccctggtcga aggcgctggg ccgtgccaag ctgctgcgat gacggcgcgc
     4201 gagcggggcg cgggccggag acttggcatc cgagaaaggg agcttgcgtg ctggagatca
     4261 ccgggccggt gaagacggaa cggctgatat tgcgtgcgtt caaagccggg gacgaggagg
     4321 acgcctacgc cttcgagtca cgagcggacg tggcccggta cctctacaac gagccgcgca
     4381 cgcgagaaga gatcaccagg ctgatgaccg agcggtccgc gcagacggtg ctgcggcgcg
     4441 agggcgacaa catccagctc gccgtcgaag gggacggcac cgtcatcgga tacgtcctgc
     4501 tgacctgggt cagcgagcgg caccagcagg gcgagttcgg atacgtgctg caccccgact
     4561 accacggccg tgggttcgcc acggaggccg ccgtcgagat gctgcgtctg ggctttgacc
     4621 ggctcggcct gcactggatc accgcccgct gcgacgcccg caacaccgcc tcggcccgtg
     4681 tgatggaacg cctcggcatg cgccaggaag cccacttcat cgagtcggag tgggtcaagg
     4741 gcgagtggac cagcgaactc cactacgccc tactcgcccc cgagtggcgc gcttcccgct
     4801 gggcgagcaa tccctgagcc gagcgggtgg ccacccctgc ggctccgggc cagcacactt
     4861 ctgacgagcg acactgcgga cgggctggag cgccagcaga aaggtgcagg ccggttgtga
     4921 aggcgtgtga cagggtaggc tcttctggca gtcgccaggt caacttcact tggcttaagg
     4981 aagattgacg cagcatgagg ttgtcaaaga agatcgccat cgccgccgcc acggtcatca
     5041 cggcagcccc cgggaccctc gttgctgcgg aacctgccac cgccgcgccg gagcccttga
     5101 tctccactgc ccccgggtcc caggctcctc cagcggtgct caccggcccg aacggcgagc
     5161 agccgacgca gtggggggtg gctgtggttc cggtcgcctc atccaggggc gcgatgacgc
     5221 ctctggccac gaagaaggtc gggggaggga catggaacta cgggacgagg gctgccgggc
     5281 tggacgggag cacctgctac tccaactaca tacacccgtc taagaagcac acggctaccg
     5341 tcatcaaggc cgggtacacc tataaggact acgccaaccc ggacgtatgg gcgaaggcca
     5401 agataactgc tggtgcggcc tacacgtgct atacgtattg gggtgtctac tagaactccg
     5461 gaggcgaaag gccacctttc actagtcagc gcaaccttgc tgccccaagc acctcacctg
     5521 tgtggccaga agttcggcat acttgaacgc atcctctctg cagcggcggt gatcatgcac
     5581 atgcctcaac gaacgtgcta aacatcatag gcagtagtca gaaaagtcac cttgctgcgg
     5641 actctcgggc cgttacgtat atgtgcgccc taggggcagg tgctctcctg gggatcagtg
     5701 tccccttgct cctatcggcg gatgggcaac tcggacaggt ggcgcacttg gtattgagtg
     5761 cgggatgggc gtgggccgcc ctcgcctttt tccttggaat gctcagcacg tcaaagccgc
     5821 gttctgccag cacgggagcc actgcattga tcagtgcggt gtccgcctat tatctgacga
     5881 aggcgactca gggtgagtac gtcgcggtgg attatgccga cctttcgggc cagtccacct
     5941 atttcgattg gagtgcgttt cttgcgaaga tgctgctgtg gtgcttcttc ggaattcttt
     6001 tcgggccact tctaggaatc tgtggcaaca tttcgcgtaa tggtccttac cctctcctag
     6061 gccgagtcgt tgtacccctc gttgccttgg tcgaaacttc tatgcggctc catactgaag
     6121 caggggtagg gagttcgctt gctgcaacaa cgtggaccac tctccgatgg gtagcagtcg
     6181 cacttctggc ctattctctg ctgtcggcaa tgttcggcag ttggcgccag cgaactggtg
     6241 gaaaatttta ccgctattag ttgctgacat ggcgcggagc ctcctcgtga ttccttccag
     6301 tcacgtcttt gacgggctta cgtcaaagtt cgccttcgct tcttcttaca agatgatggg
     6361 atgcttccag ccgctcctca actgttgcct gatgcggacc agaagtcaga ctctgcgttc
     6421 ggggcagggg caggaccggt gtcttccttg gggtcagtga cgtcggattg ctcggcgcac
     6481 ggcgtcgatg cctggaggag agcctgcccc ttcgcgccga acatcagtct gatgcggaag
     6541 ccttctggag tttccgcgta cacggcaggg tgggtggcgc tgtcgcgtac cgcgatgatc
     6601 tcgtatccgc tctttttcca gaaatcctcg acgccgccga gaaagtttcc ccgacgctcc
     6661 ttggagatga tggtggtgac ggcacggcgg cgagacaccg ctccggtctc tgtctcctcg
     6721 tttttccaat ccgtgcacgc ttggctcgtc gtttcgccat aaacccactc gacctcaggc
     6781 ttaatcgcct tcagagtcat gtccaacaca gtatccgcgc ggttggccgc ttcttgcatg
     6841 ttcacattcg gtacattctc ggtcgaatta ttttcgctgc tctcgcccag cattccacag
     6901 gcggaaaggg gtagaatgag tagcagtgct gtcatggtgc ggagcctcac cgtggtgcct
     6961 ccgagatcac gtcttcgggt tttccggcaa cgatggcggc gacgttgtcc gccgatagct
     7021 ggtccttctc agggttgaaa tagttcgagt gtgcaggcat cggcccttca ccatcgatat
     7081 atgggcgagg tccatcgtca acggcaaagc ggttggcgcc gaacgccccg cttgctgggt
     7141 cctttccgaa ccagatgtcg tcgtcgccga tatcggcgag ctcataccaa aggtatgctg
     7201 taattgggtt agttgacgta aatccctcga tcgcgccatc gatttctgct ttcgaaggaa
     7261 gtttggtcac cggatcgttc tctgcagcgc caacgtatac gtggtcacta tcgaccccaa
     7321 gctcagacgc gtgctcagcg cttacccccg gactccccag caggataatg tcatctgcgc
     7381 ccggaattcc gcctgggcgt tgagctgcca agccgactgt aagagatcca taagaatggc
     7441 cgatcgctgt gatatgcggg tcggtgtgct cgttagtggc tccgaggcct tcgatgaatg
     7501 cattgtatgt cggtgcgcca gccgtagcat gaatttcggt catcacagct gcgttgttga
     7561 tgaccttatc agttcccatt tggggcgcgt cgtatcccag ccaaacgatc gaagcgctag
     7621 aggggtcgtg atcttgtgcg ccgagggcgg tgtggcgggc acgttcgagg tcgttcttgg
     7681 caaacgcctc atccagagct gttcccaggc ccgggacgta ggcggagacg ttgcgggagg
     7741 tgtcggggtt gccgtagctg acgatggcac ggccgttgcc ttcgtcgccg atgcccaaga
     7801 ggtacatggg cgggacactg cccttctgaa gcttctcctc gatgactacc aggcccgcga
     7861 gtttggtgcg ggcgtcctcc gtgtcctctc cctccagttt gcccatcagt agggggaggt
     7921 aggtgcggtt ggcttcgtcg cgggcggcgg cggggatgcc gtcgaggttg ccgatgagat
     7981 cggggtggag ggtgaggtgt tgggcgcgtt cgcccgccga gagtccgtcc caccattcct
     8041 tgcgttcggc ggcggagagg tccgtgggga tgtcgctggc gtcgaggtag ccgtaggcgg
     8101 cttcgcggac ggcggtggag tcctcgtggg cgtcggtcca catcgcgtcg gtgacgtcga
     8161 ggccgggctt ggtggtcagc ttgctgagcg cttccgcgta gctgtcgtcg atctcgcggg
     8221 cgtccttggc ggcgcggtag aggcggtcgg cgatgtcctg ggcctcgtgc cggttggggt
     8281 tggggtccag gagggggttt ggcaccaggg gctgggagac gagccattcg cccgtcagga
     8341 gcgtgctggc cgtgacggtg ccgcccgggg ccggtgagcc gtccaggagt tcacccttgg
     8401 ccgggtaggt gacggctccg tcggctccca cggtgaactt cagcgactcc gcgtcgtcca
     8461 gggcgttgtt caccgccttc tggtggggta gcagttcctc tgccaggccg gtcagcgcgg
     8521 tgttgatcag tccgcactcc gtgtagatgt actggtagtt ctcactgagc gtggtcaagc
     8581 gtgtgacagc ggccttcgtg gcctctcctt cctcggtgtc gtccagcgcg gcggttcgct
     8641 ggttgagggt ctgccgggcg gcgtgggcgc ggtcgcggac cccggcccag ccgctcgcgg
     8701 cggcgtgcag gccgctcagg tcgagatcgc ggagttcgga ccaggtgagg gtactgggca
     8761 tgggtcagcg gccgccttcc gccccggtgg gcgcctgggc gcccttgaac gtggacgtgg
     8821 tggccgcctc gttctcgccg tgctccttgg ctaccgcgcg cagcttgggc gccaggttct
     8881 cgcattcctc gcgggcggac tccagccgtt ccacccaggt ttcgcgcacc ttggtgagct
     8941 tgctgacgct ggccaggccc gccccctcgg cggcgatgtt ctcgtgggag gtctccagct
     9001 tgttcttggc ctgcgccagc acgttcgcca tgccgtctac cgagttgctc gccgaggtcc
     9061 aggggcctgc gctgtgccgg agcttgccgc cttccggggc gccgccgtct gctgaggcga
     9121 gggccagcag ggggctgggg ctggtgccgt ctgggctgct ggcggggctg gcgcttgggg
     9181 gccgctgctc ggccagagcg aagagctgct gccatacctc tggcgtggcg tcaggcgaca
     9241 tacggtctcc gggtggtgcg ggtgggaggt ggcccgtcag ctccgccagg ctacggcgac
     9301 aacagacatg gtcaggtggc acaccggcgg ccacctgggg cattctgccg gagcggaggg
     9361 gcggggatca tgagtacgcg tactcagatc cgctggcccc ggacgcagcg gtgccccgcg
     9421 cccggcggct ggccgggggc ggggcaccgt ggggtaccgg caggcgtcag aggccgagtt
     9481 cgccctcgaa ctcggcggcc tccaggcggg ccttgacgtc cgcgaggtag cgggcggcgt
     9541 cggcgccgtc caccagctgg tggtcgtagg agagggtcag gtaggtcatg tcgcggatcg
     9601 cgatggtctc gcccagctcc gggtggtcga tgacgaccgg gcggcgcacg gtggcaccga
     9661 tgcccagctc ggcgacctgc gggtagttca cgatgatcgt gtcgaacagc gcaccgcgcg
     9721 agccggtatt gctgatcgtg aacgtgccgc cggacatgtc gtccgggctg agcccgccgc
     9781 cgcgtacctt gcccgccagc tcggcggtgc gcttggcgat gcccgccagg ctcaggtcgc
     9841 ccgcgccctt gatgacgggg accatcaggc ccttctccga gtccaccgcg atgccgacgt
     9901 tctcgacgtc gtggtaggtc acggtgccgt cgtcgttaat cttggcgttg acggccgggt
     9961 ggaccttcag cgcctcggcg gcggccttga cgaagaacgg catcggcgag agcttcacgc
    10021 cctcccgggc caggaaggac tccttggccc gggcgcggag cttcatgacc cgggtgacat
    10081 cgacctcaac cacggtggag agctgcgcct ggttgtgcag cgccttcatc atgttctcgg
    10141 cgatgacctt gcggatgcgg gacatcttca ccgtctgccc gcgcagctcg gacggctggg
    10201 ccgcctgggc cttcggggcg gacggtgcgg cggcggccgg agccggggtc ttggcggcct
    10261 cggcggcggc caggacgtcc tgcttgcgga tgcggccgcc gacgccggtg cccttcaccg
    10321 tggacaggtc cacgtcgttc tcgcccgcga gcttgcggac cagcggggtg acgtaggcgc
    10381 cctcaccacc ggccggggac gcggcgggct gctgggcctg cgcggccgga gccggggcct
    10441 gctgcgccgg ggc
//
