LOCUS       NZ_JAEVFI010000002     25195 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Streptomyces sp. JJ66 scaffold2_size363742, whole genome shotgun
            sequence.
ACCESSION   NZ_JAEVFI010000002
VERSION     NZ_JAEVFI010000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. JJ66
  ORGANISM  Streptomyces sp. JJ66
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 363742)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Draft genome of Streptomyces sp. JJ66
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 363742)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2021) Marine Biotechnology and Ecology Division,
            CSIR - Central Salt and Marine Chemicals Research Institute, G.B.
            Marg, Bhavnagar, Gujarat 364002, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2017
            Assembly Method                   :: Velvet v. V 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 320.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019303495.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 03:51:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,515
            CDSs (total)                      :: 4,446
            Genes (coding)                    :: 4,340
            CDSs (with protein)               :: 4,340
            Genes (RNA)                       :: 69
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 31 of 106
            Pseudo Genes (incomplete)         :: 82 of 106
            Pseudo Genes (internal stop)      :: 3 of 106
            Pseudo Genes (multiple problems)  :: 9 of 106
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:22:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 135625
            Orig. end                         :: 160820
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAEVFI010000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25195
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25195
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25195
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15195](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15195)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(59..74)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.79"
                     /tool="antismash"
     gene            complement(762..1898)
                     /gene="dusB"
                     /locus_tag="JJV70_RS02620"
                     /old_locus_tag="JJV70_02625"
     CDS             complement(762..1898)
                     /EC_number="1.3.1.-"
                     /GO_function="GO:0017150 - tRNA dihydrouridine synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="dusB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010042159.1"
                     /locus_tag="JJV70_RS02620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02625"
                     /product="tRNA dihydrouridine synthase DusB"
                     /protein_id="WP_219045916.1"
                     /transl_table=11
                     /translation="MARQLRIGPHDVTPPVVLAPMAGITNAPFRTLCRDFSGGKGLFVS
                     EMITTRALVERNEKTMRLIRFDAGERPRSIQLYGVDPVTVGKAARMIADEDLADHIDLN
                     FGCPVPKVTRKGGGSALPYKRNLLREILREAVTGAGGLPVTMKTRKGIDDDHLTYLDAG
                     RIAAEEGVSAIALHGRTAAQHYSGTADWSAIARLREAVPAEIPVLGNGDIWCAQDAVRM
                     MRETGCDGVVVGRGCLGRPWLFGDLVALFEGREDEVARPTLREVADVMVRHARLLGEWL
                     GDEARGVIDFRKHIAWYTKGFSVGSQARSRLAVAASLTELRELLDGLELDQPWPAGAEG
                     PRGRTHGRNRVVLPDGWLDDPYACTTVTADAELDTSGG"
     gene            complement(1980..2453)
                     /locus_tag="JJV70_RS02625"
                     /old_locus_tag="JJV70_02630"
     CDS             complement(1980..2453)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016468881.1"
                     /locus_tag="JJV70_RS02625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02630"
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_219045917.1"
                     /transl_table=11
                     /translation="MATAGPPVRGRSTRQRAAVSAALSEVDEFRSAQELHDMLKHRGDS
                     VGLTTVYRTLQSLADAGEVDVLRTDEGEAVYRRCSTDDHHHHLVCRSCGKAVEVEGPAV
                     EKWADAIAAEHGFRDVAHTVEIFGTCGECAAVRAAKAQDQEAARVGSTARGRK"
     gene            complement(2558..3436)
                     /locus_tag="JJV70_RS02630"
                     /old_locus_tag="JJV70_02635"
     CDS             complement(2558..3436)
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_process="GO:0030001 - metal ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1245: ABC transporter
                     protein, integral membrane"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016468880.1"
                     /locus_tag="JJV70_RS02630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02635"
                     /product="metal ABC transporter permease"
                     /protein_id="WP_219045918.1"
                     /transl_table=11
                     /translation="MIEILDYAFMQRALLAALLVGIAAPAVGIYLVQRHQAIMGDGIGH
                     IALTGVALGFLLSTNAVWTAVLVAAAGAVAIELVRWYGKARGDIALAMLFYGGMAGGVM
                     IINLAPGGSTGDLLTAMFGSITTVSPEDVTAIVVLSCAVLAICLGLRRQLFAVCQDEEF
                     ARVTGLPVKLLNLLLAVTAAVTVTVAMRVVGLLLVSALMVIPVAAAQQVTRGFAVTLGL
                     SVVLGVLVALSGTAVSFYVDVPPGATIVLLAIAAFAVLAALTPAVARRRARLAARSEPS
                     GMLEGEPVRGG"
     gene            complement(3433..4221)
                     /locus_tag="JJV70_RS02635"
                     /old_locus_tag="JJV70_02640"
     CDS             complement(3433..4221)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020207432.1"
                     /locus_tag="JJV70_RS02635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02640"
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="WP_308294647.1"
                     /transl_table=11
                     /translation="MKASVTEPATDPVIALRGVHAALGARPVLRGIDLTVGRGEVVALL
                     GANGSGKSTAVRAAIGQVPLTGGELEVFGTPLRRFRAWHRLGYVPQRSTAAAGVPATVR
                     EVVSSGRLARRRLRPLGRADRDAVTRAVDLVGLGDRARDSVSALSGGQHQRVLIARALA
                     AEPELLIMDEPLAGVDLASQRVLATALRAQVSEGTSVLLVLHELGPLAPLIDRSVVLRD
                     GRVERVEHPEQLHDLACHPHDSAVPAEAPVAPRIGTGLPS"
     gene            complement(4257..5459)
                     /locus_tag="JJV70_RS02640"
                     /old_locus_tag="JJV70_02645"
     CDS             complement(4257..5459)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006124314.1"
                     /locus_tag="JJV70_RS02640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02645"
                     /product="metal ABC transporter substrate-binding protein"
                     /protein_id="WP_219045921.1"
                     /transl_table=11
                     /translation="MNARRRPLIAGPALAGASVLSLLTLSACGSGSAGTTEDGKLSVLA
                     SFYPMEFLAERVGGEHVSVTTLTQPGVDPHDLELTPRQTAELTEAGAVLYLKGMQPAVD
                     DAIKQSGAEHVVEASALAEAAAGGGAEPQGGRTDHGPDEENHGDAGHDDHGHGEHGHGE
                     EHGDHGHGEEHGDHGHGEEHGEHGHGEEHGEGEPTGDEPASDEPTEEDAHEGHDHEHDH
                     DHDHGGKDPHIWLDPVQYAAVAEGVGEALAKADPDHAADYRKNADELSAELEQLDTEFE
                     QGLSNTATDTFITTHAAFGHLAARYGLHQEPITGLSPETEPSGARLKELHTIAEEDNVS
                     TVFFETIASDRTAKALAADLNLDTDVLDPLEGITDASRGDDYFAVMRANLEALQKALGA
                     K"
     misc_feature    complement(5454..5469)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.56"
                     /tool="antismash"
     misc_feature    5457..5472
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    complement(5459..5472)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.65"
                     /tool="antismash"
     misc_feature    5459..5473
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 25.32"
                     /tool="antismash"
     misc_feature    complement(5466..5480)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.99"
                     /tool="antismash"
     misc_feature    5467..5480
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.38"
                     /tool="antismash"
     misc_feature    complement(5468..5481)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.47"
                     /tool="antismash"
     misc_feature    5479..5494
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.05"
                     /tool="antismash"
     misc_feature    5481..5495
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(5483..5494)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.21"
                     /tool="antismash"
     misc_feature    complement(5487..5503)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.43"
                     /tool="antismash"
     misc_feature    5499..5514
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.57"
                     /tool="antismash"
     misc_feature    complement(5557..5570)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            5626..7008
                     /locus_tag="JJV70_RS02645"
                     /old_locus_tag="JJV70_02650"
     CDS             5626..7008
                     /EC_number="6.1.1.14"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0004820 - glycine-tRNA ligase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006426 - glycyl-tRNA aminoacylation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005317958.1"
                     /locus_tag="JJV70_RS02645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02650"
                     /product="glycine--tRNA ligase"
                     /protein_id="WP_219045923.1"
                     /transl_table=11
                     /translation="MAADKIDTIVSLSKRRGFVYPCSEIYGGQRAAWDYGPLGVELKEN
                     IKRQWWRTMVTSREDVVGIDSSVILASEVWQASGHVATFTDPLTECTSCHKRFRADHLE
                     EAYEAKHGRLPEGGLADLNCPHCGNKGTFTEPKQFSGLLSTHLGPTQDSGSVAYLRPET
                     AQGIFTNFSQVQQTSRKKPPFGIAQMGKSFRNEITPGNFIFRTREFEQMEMEFFVKPGE
                     DEQWHEYWMEQRWNWYRELGLSEANMRWYEHPAEKLSHYSKRTADIEYRFSFGGSEWGE
                     LEGVANRTDFDLGAHSKASGQDLAYFDQEAGERWTPYVIEPAAGVGRTMLAFMLDAYVE
                     DEAPNAKGKMEKRTVMRLDPRLAPVKVAVLPLSRNEQLSPKARGLAQTLRGHWNIEFDD
                     AGAIGRRYRRQDEIGTPFCVTVDFDTLDDNAVTVRERDTMKQERVSLDQVESYLASRLI
                     GC"
     gene            complement(7088..7912)
                     /locus_tag="JJV70_RS02650"
                     /old_locus_tag="JJV70_02655"
     CDS             complement(7088..7912)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017944985.1"
                     /locus_tag="JJV70_RS02650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02655"
                     /product="isoprenyl transferase"
                     /protein_id="WP_219045925.1"
                     /transl_table=11
                     /translation="MLSRQPHASRGYAAPAPHPSGARPPQLPAELVPNHVAIVMDGNGR
                     WAKERGLPRTEGHRMGEGVVLDVLRGCLEIGIPNLSLYAFSTENWKRSPEEVRFLMNFN
                     RDVIRRRRDEMDAMGIRIRWVGRMPKLWKSVVQELQTAQEQTKRNTAMTLYFCVNYGGR
                     AEIADAAQAIARDVAAGRLDPGKVNEKTFAKYLYYRDMPDVDMFVRPSGEQRTSNYLIW
                     QSAYAEMVFQDVLWPDFDRRDLWRACLEYAKRDRRFGGAIPNELSAQAPPQR"
     misc_feature    7903..7917
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.75"
                     /tool="antismash"
     misc_feature    7959..7974
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            complement(7960..8709)
                     /gene="recO"
                     /locus_tag="JJV70_RS02655"
                     /old_locus_tag="JJV70_02660"
     CDS             complement(7960..8709)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019436216.1"
                     /locus_tag="JJV70_RS02655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02660"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_219045927.1"
                     /transl_table=11
                     /translation="MSLFRDDGIVLRTQKLGEADRIITVLTRGHGRVRAVARGVRRTKS
                     KFGARLEPFSHVDVQFFARGSDLVGRGLPLCTQTETIAPYGRGIVTDYARYTAGTAMLE
                     TAERFTDHEGEPNVQQYLLLVGALRTLAADAHAPGLVLDAYLLRSLAVGGYAPSFDACA
                     QCGMPGPNRFFSVAGGGCVCPDCRRPGSVVPSPEALRLLAALLTGDWPAADAAEPRHVR
                     EGSGLVSAYLHWHLERGLRSLRYVEKG"
     gene            complement(8878..9996)
                     /locus_tag="JJV70_RS02660"
                     /old_locus_tag="JJV70_02665"
     CDS             complement(8878..9996)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326258.1"
                     /locus_tag="JJV70_RS02660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02665"
                     /product="hypothetical protein"
                     /protein_id="WP_219045929.1"
                     /transl_table=11
                     /translation="MIPAIASRIPLVKRSKAPALPLDERITHLTGLTVAPAGAGHRDLV
                     ARACGVLNYGALIVSDVGMPGLAAELCWRQHRVFADARHLPGDVAVMSLMPLINISRLL
                     IRNGDGHTAYDVLTRLYRAAQQRATTVIDGNTIDLSALIRTEADHRRICQELWVTLLVD
                     GARALARIGRWTEAADAMTAHRGIGNRLLDGRQIMIMSLLERGLDQQARDAIDSAVPTE
                     PWENAIAALLRICCRSEGAPAPELDRAVQEALTLLTPPESSTAAFQTRVGLAALDLTCG
                     QADACLASLCDALADAARLDAYAAREVLAHHTARSHLTSEQRQRLRAAVTASGLGVGGL
                     PQAHMQVVSEGVDKAEVALRELLEPPLADGLG"
     gene            complement(10001..12055)
                     /gene="fxlM"
                     /locus_tag="JJV70_RS02665"
                     /old_locus_tag="JJV70_02670"
     CDS             complement(10001..12055)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="JJV70_RS02665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02670"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_219045931.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.1e-19, bitscore:
                     65.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 2.2e-43, bitscore: 142.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFDDDENLPIAHDTTWWHASVAFPGGTVTPEAAHALSAALHETR
                     FHFLRKDAGLRLRTERPSVALLDRLAAERYITGWVGGVYEPEAEAFGGTEGMDVAHDVF
                     CADSRSALPETGSTGNRERCVMLLSVLNRAAGLDPFEVGDVWSQFAALRPSVTAPAVPA
                     LDRSVAAMRRLMNADAARRPDAEAGWADRVAAFADAGRRLRRLATDGQLIRGLRAVLAH
                     HAIFAFNRAGVPVTEQAATAWLGRQVAFSTTADTPVSTRRSTPPDPDLPRMETTVTPVT
                     DPAEPREALADRLVESGHLRTSVIIGAFRATDRHTFLPSVDREVAYKEEAVPIKHDEHG
                     EMISCISAPSIVATQLEQLDVQPGHQVLEAGAATGYNANLLGKLVGPTGQVWTLDVDQD
                     LIDGANKNLARAGATNVTAVLADGAAGLPEHAPYDRIQFTVGAGDVPAKLLDQLAPNGR
                     LVLPMRIRGSISRSFAFERDGDTWKTVSCEMCTFIPLRKGVCDDVCTLVPMEGEGNVRL
                     ETFSEQDVDRDALRTALDTPQAKIFTGVKLRQGAPFEWMYLYLACALPNGLSRLPGSRP
                     GFTPHFGWGSMAALEGGSLAYLTIREGEDEAGRFWEVGVIGHGPGGADLADRFVTEIRT
                     WDEGWGNAAPEPGFRMAVGDARDQLTAADPRFVIDKPYSRLIVDWPRKG"
     gene            complement(12088..12651)
                     /locus_tag="JJV70_RS22400"
     CDS             complement(12088..12651)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="JJV70_RS22400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_308294648.1"
                     /sec_met_domain="LANC_like (E-value: 2.6e-23, bitscore:
                     76.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAHGIAGPLTVLSLAARQGHFVPGQHEAIEVFARWLDRYGGHYWT
                     TRAHLDAAEPPEPGPARPSWCYGLPGMARAQQLAALALGDPARRQAAEDALVQTLTEPA
                     QLARITDATLCHGWAGLLTVARAIAADSPTPERFLPVISDLLRRLATDLNRLSKPGFME
                     GRSGAQLALDGTNATHWTTVLLIT"
     gene            complement(13156..15195)
                     /locus_tag="JJV70_RS02675"
                     /old_locus_tag="JJV70_02680"
     CDS             complement(13156..15195)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="JJV70_RS02675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02680"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_257573222.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.1e-16,
                     bitscore: 55.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2e-104, bitscore:
                     344.3, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRARHRLYQGTGQGMLRAAAHLTEPVMAPWPGRSASLDEWRSWL
                     GTVWADENFQQAVSSASPDLAHQVQAILDGCAPKLRRVRRAALATARYAIRYTRRSTPY
                     GLFAGVALVEFGDTASVRFGDRHQAVTRPDPVELDEAISAWEADGTRMADAGVCVHPLA
                     RQRDGRVRVPSEGDAEFRLALSSPALRFVLDAARTPVRYSLLVDKLAAEFPDTSGQARR
                     QLLAELLRVRLLWSSLRAPATVVDPAQVLPPVLRAQVRDRATAADLRLDAEVRLPQEVL
                     TEAETAATVLARLATHPNGTPPWRRWAEQFTDRYGENTAVPVEVATDPCQGIGFPDGFV
                     KAAEPPRPMSHRDRLLLELAGTAAVEGARSVPLTGAMIEELEAAGEKPRLTAPHIELAA
                     HIHAASSEALQRGNFRLRVVTVSRSAGSMTGRFWHLFPETGTTYTDLPTIEPGAELAQL
                     SFHAGRVPADLLTRAPHVLPRIVSVGEFRRPGDGVLFPSDLAVSVRDGRPRLVEIATGT
                     CLELLAPTAINFLWNNYTPPMARFLGEISRALAPQVTWFDWGVAWTLPFTPALTYRRTI
                     LTVARWKVRARELPGRTATAKEWAEQLHAWQSRFTVPNRVLLAEDDQQLPLDLSQDMHL
                     DLLRAHLDASPIGVATLQEAPPPDADKWINGRAHSLVLPLAVRT"
     aSDomain        complement(14473..14727)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JJV70_RS02675_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.60E-18"
                     /identifier="RREFam001.1"
                     /label="JJV70_RS02675"
                     /locus_tag="JJV70_RS02675"
                     /protein_end="241"
                     /protein_start="156"
                     /score="55.7"
                     /tool="antismash"
                     /translation="VCVHPLARQRDGRVRVPSEGDAEFRLALSSPALRFVLDAARTPVR
                     YSLLVDKLAAEFPDTSGQARRQLLAELLRVRLLWSSLRAP"
     gene            complement(15274..15456)
                     /locus_tag="JJV70_RS02680"
                     /old_locus_tag="JJV70_02685"
     CDS             complement(15274..15456)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="JJV70_RS02680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02685"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_219045933.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 9.3e-17, bitscore:
                     55.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESTAVATATAPVPSVEAQPDPFGLDITFIEGTPATETVLMCST
                     GDTCGSSCPSACVTS"
     CDS_motif       complement(15343..15456)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSESTAVATATAPVPSVEAQPDPFGLDITFIEGTPATE"
                     /locus_tag="JJV70_RS02680_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15274..15342)
                     /prepeptide="core"
                     /locus_tag="JJV70_RS02680_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-9.90"
                     /molecular_weight="1948.2"
                     /monoisotopic_mass="1946.8"
                     /core_sequence="TVLMCSTGDTCGSSCPSACVTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSESTAVATATAPVPSVEAQPDPFGLDITFIEGTPATE"
                     /leader_location="[15342:15456](-)"
                     /alternative_weights="1966.2"
                     /alternative_weights="1984.2"
                     /alternative_weights="2002.3"
                     /alternative_weights="2020.3"
                     /alternative_weights="2038.3"
     gene            complement(15666..16634)
                     /locus_tag="JJV70_RS02685"
                     /old_locus_tag="JJV70_02690"
     CDS             complement(15666..16634)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="JJV70_RS02685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02690"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_219045934.1"
                     /transl_table=11
                     /translation="MPYPSSGLGDNLRAHRRVAGLSQEELANDAGLSVSVVRKVEQGGQ
                     ARVETLHCLARALNIPTSALFAADSPEPVIGDEANRQMLMTLRKALMPPVGIRQTLTDP
                     GGAEPLAKLWRQVGEGHTLHFADRYDSVARTLPGLLRATEAAVASAEDDTDRQEAMRVR
                     SHALLFAGKHLTHVRQYDMAYHALSEGIRLAREVNDTAWAATGVSGMCWLLLRQDRFDE
                     SERLAAVTADQMEPRMSSATVSELAAWGELSLWIASAAVRNNRPDEAAEARRMAATAAS
                     ALGQEHTDFRQHWSTFGPVTAELKAVEDLGLAGDWHGVLRL"
     gene            complement(17224..17868)
                     /locus_tag="JJV70_RS02690"
                     /old_locus_tag="JJV70_02695"
     CDS             complement(17224..17868)
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007265581.1"
                     /locus_tag="JJV70_RS02690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02695"
                     /product="HAD family hydrolase"
                     /protein_id="WP_219045936.1"
                     /sec_met_domain="HAD_2 (E-value: 7.2e-09, bitscore: 30.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRAIALDIGETLTHDTRYWASWADWLGIDRHTLSALVGAVVAQG
                     RDNAEAVRLLKPGVDLEAEYAAREAAGLGERLEESDLYDDVRPALTALREAGVRVVAAG
                     NQTRVAGRELRGLKLPVDAVATSGEWGVAKPSAEFFLRVVDLADVSDPGQVLYVGDHPP
                     RDVFPAREAGLMTAHLRRGPYGHLWADDPRVREASDYRIDSLHDLAAIVRG"
     gene            complement(18102..18356)
                     /locus_tag="JJV70_RS02695"
                     /old_locus_tag="JJV70_02700"
     CDS             complement(18102..18356)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJV70_RS02695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJV70_02700"
                     /product="protealysin inhibitor emfourin"
                     /protein_id="WP_219045937.1"
                     /transl_table=11
                     /translation="MHITVIRTGGQGGQPRRAALDTTDTELTELARTALAEGHETPPVG
                     GPEGFSYEIIADDTTTYCADPRLTPAQSALITRVLHAAE"
     gene            18593..20362
                     /gene="leuA"
                     /locus_tag="JJV70_RS02700"
                     /old_locus_tag="JJV70_02705"
     CDS             18593..20362
                     /EC_number="2.3.3.13"
                     /GO_function="GO:0003852 - 2-isopropylmalate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009098 - L-leucine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="leuA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179745.1"
                     /locus_tag="JJV70_RS02700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02705"
                     /product="2-isopropylmalate synthase"
                     /protein_id="WP_219045939.1"
                     /sec_met_domain="HMGL-like (E-value: 4.2e-74, bitscore:
                     243.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTISSSQPVGRATPVTAASVAQRPSGMPIHKYGPYESVDIPDRTW
                     PNARITKAPRWLSTDLRDGNQALIDPMSPARKREMFDLLVGMGYKEIEVGFPSSGQTDF
                     DFVRSIIEEGAIPDDVTISVLTQAREELIERTVESLVGAPRATVHLYNATAPAFRRVVF
                     RGTREQVRQIAVDGTRRVMEYADKLLDARTTFGYQYSPEIFTDTELDFALEVCESVMDV
                     WQPEEGREIILNLPATVERSTPSTHADRFEWMSRNLSRRAFVCLSAHPHNDRGTAVAAA
                     ELAVMAGADRVEGCLFGQGERTGNVDLVTLGMNLFSQGVDPQIDFGQIDEIRRTVEYCT
                     QMEVHPRHPYAGDLVYTAFSGSHQDAIKKGFDALEASAAAAGKTVDEVVWEVPYLPIDP
                     KDVGRSYEAVIRVNSQSGKGGVAYVLKNDHNLDLPRRMQIEFSRIIQEKTDAEGGEITP
                     AQIWEIFRDEYLPTPERAWGRIALRSAQSESTTDGHDALTVEAVVDGVATVLKGHGNGP
                     ISAFFDALAHHGIDVRLLDYVEHTLSEGASAQAASYIECAIDGKVLWGVGIDANTTRAS
                     IKAVVSAVNRATR"
     misc_feature    complement(20448..20461)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.19"
                     /tool="antismash"
     gene            20569..21225
                     /locus_tag="JJV70_RS02705"
                     /old_locus_tag="JJV70_02710"
     CDS             20569..21225
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019523165.1"
                     /locus_tag="JJV70_RS02705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02710"
                     /product="TerB family tellurite resistance protein"
                     /protein_id="WP_219045941.1"
                     /transl_table=11
                     /translation="MRAGLRTGVRVAWTAVADGSFFCPRCGGDRNYERRTGRRRLELLG
                     VPLVRGGVTTPVLACATCATHVSPQALEHPTSTRLAALLGDGVRAVALAVLALGGTEHP
                     AAVRAAVETVHAAGYPECTEEELLSACAALRGYGADAEEARVGVEIALHAALGPLVPHL
                     AAPGRASLLVRGARVALADGPYLPAERAVLASLGSALELSAGEIDALLAAAPERR"
     gene            complement(21278..22219)
                     /gene="era"
                     /locus_tag="JJV70_RS02710"
                     /old_locus_tag="JJV70_02715"
     CDS             complement(21278..22219)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="era"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018889974.1"
                     /locus_tag="JJV70_RS02710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02715"
                     /product="GTPase Era"
                     /protein_id="WP_219045943.1"
                     /transl_table=11
                     /translation="MGRMSDPSPTPHRAGFACFVGRPNAGKSTLTNALVGTKVAITSNR
                     PQTTRHTVRGIVHRPEAQLVLVDTPGLHKPRTLLGERLNDVVRTTWAEVDVIGFCLPAD
                     QKTGPGDRFIAGELAQLKRTPKVAVVTKTDLVDSKALAEQLLAVDRMGRELGFEWAEIV
                     PVSAKDGTQVSLLADLLVPMLPQSPPLYPGGDLTDEPEQVMVAELIREAALEGVRDELP
                     HSIAVVVEEMLPREGRPADRPLLDVHANVYIERPSQKGIVIGPGGKRLKEVGTRSRQHI
                     EALLGTPVFLDLHVKVAKDWQRDPKQLRRLGF"
     gene            complement(22444..22794)
                     /locus_tag="JJV70_RS02715"
                     /old_locus_tag="JJV70_02720"
     CDS             complement(22444..22794)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129632.1"
                     /locus_tag="JJV70_RS02715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02720"
                     /product="cytidine deaminase"
                     /protein_id="WP_219045945.1"
                     /transl_table=11
                     /translation="MTEAHAIDPEDRKIIVLARSARARNGVAEGAAVRDETGRTYVAAT
                     VGLPSLELSALRTAVAMAVASGATSLEAGAVVTEAEALADADLAAVADLGGTTPVLLAG
                     PDGTVRTTLTAG"
     gene            complement(22884..24203)
                     /locus_tag="JJV70_RS02720"
                     /old_locus_tag="JJV70_02725"
     CDS             complement(22884..24203)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1273: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018537991.1"
                     /locus_tag="JJV70_RS02720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02725"
                     /product="hemolysin family protein"
                     /protein_id="WP_219045947.1"
                     /transl_table=11
                     /translation="MTTLIAFAVALIVLAWLAACAEAGLARTTSFRAEQAVRSGRRGSA
                     KLAAVAAEPVRYLNLAMLLRVASEMAAGVLVTYVCVRSFDQTWQAITVAIAVMVLVSYV
                     AVGVSPRTIGIQHPLNTATAAAYVLLPLARVLGPLPQLLILLGNALTPGKGFRRGPFAS
                     EAELRAMVDLAESESLIEDEERRMVHSVFQLGDTLVREVMVPRTDLVTIERFKTIHQAL
                     TLALRSGFSRIPVIGENEDDVVGIVYLKDLARKVHISREAESELVATTMRPAAFVPDTK
                     NAGDLLREMQVQRNHVAVVIDEYGSTAGIVTIEDILEEIVGEITDEYDRELPPVEELGE
                     GRYRVTARLSLDDLGELYGLADYDDEDVETVGGLLAKLLGRVPIAGARAVADLSGDPAD
                     PTLAGLRLTAESTAGRRNRIDRVLVERVSAPRDAEPADGA"
     gene            complement(24224..24721)
                     /gene="ybeY"
                     /locus_tag="JJV70_RS02725"
                     /old_locus_tag="JJV70_02730"
     CDS             complement(24224..24721)
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0042254 - ribosome biogenesis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ybeY"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003957737.1"
                     /locus_tag="JJV70_RS02725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_02730"
                     /product="rRNA maturation RNase YbeY"
                     /protein_id="WP_219045949.1"
                     /transl_table=11
                     /translation="MSIDVNNESGREVEEQAILDIARYALTRMRIHPLSELSVIIVDTE
                     AMEQLHTQWMDLPGPTDVMSFPMDELRPPGKDDDEPPQGLLGDIVLCPEVAARQAEQAP
                     TGHTMDEELQLLTVHGVLHLLGYDHEEPGERAEMFGLQQAIVDGWRDEHGLTGPSPAPT
                     VT"
ORIGIN
        1 cgctacgtgc ggctggccgc cgcgtaccgc gacgccgggt acgacgacac gcgcgcggtg
       61 ttcgccttcg ccgtggagga cccgggcttc aacgcgctgc tgacggcctc cgagcacgcc
      121 cttgccgaga tcgcgcagga gctgggcgcc gaccctcagc cgcaccgccg ccgcgcccgg
      181 gagctgaccc aggccatgga gcgccgcctg tgggacccgc aggccgggca gttccgctgc
      241 cgcgacctga tcgacggcac cctcatcgac gagcgcagcg ccgccgggct gctgccgctg
      301 gccctgccgg acctgccgga gccggtggta gaggcactgg tgcgcacgct tcagggcccg
      361 cacttcaccc cacggcccgc ccgggatgcc cagcccgtgc acgccacggg cacggcggcg
      421 gacgcgggtg acgcgggcac ggtgggcgac gcgggcgaca cggcccacga tgcggacgcg
      481 gacaccgcgc ccggactcgt cccgagctac gacctgcgcg gccgggcctt cgaccgccgc
      541 cgctactggc gcggcccggc ctggttcaac gtcaactggc tgctggagtc cggcctgcgc
      601 cgctacggcc acaccgagcg ggccaacgcg ctgcgggagg cgatactcca cgcggcggac
      661 gccaccgggt tcgccgagta cgtcgatccg ctgaccggtg ccgggcgcgg cgcccgcgcg
      721 ttcggctgga cggccgcgct caccctggac ctgctggcga atcagccgcc ggaggtgtcc
      781 agttcggcgt cggcggtgac cgtcgtacag gcgtaggggt cgtccagcca gccgtcgggc
      841 agcaccacgc ggttgcgccc gtgggtgcgg ccgcgcgggc cctcggctcc ggcgggccag
      901 ggctggtcca gctccagccc gtccagcagt tcccgcagtt cggtgaggga agcggcgacg
      961 gccagtcggc tacgcgcctg ggagccgacg gagaagccct tggtgtacca ggcgatgtgc
     1021 ttgcggaagt cgatgacgcc gcgcgcctcg tcgcccagcc actcccccag cagccgcgcg
     1081 tgccgcacca tgacgtcggc gacctcgcgc agggtgggcc gggccacctc gtcctcgcgg
     1141 ccctcgaaga gcgccaccag gtcgccgaac agccacgggc ggcccaggca gccccggccc
     1201 acgacgaccc cgtcgcagcc ggtctcgcgc atcatgcgga ccgcgtcctg ggcacaccag
     1261 atgtcgccgt tgccgagcac cgggatctcg gcgggcaccg cctcgcgcag gcgggcgatg
     1321 gccgaccagt cggcggtgcc ggagtagtgc tgggcggcgg tgcggccgtg cagggcgatc
     1381 gcgctgacgc cttcctcggc ggcgatgcgg cccgcgtcga ggtaggtgag gtggtcgtcg
     1441 tcgatgccct tgcgggtctt catcgtcacc ggcaggccgc ccgcgccggt gaccgcctcg
     1501 cgcaggatct cgcgcagcag gttgcgcttg tagggcagcg ccgagccgcc gcccttgcgg
     1561 gtgaccttgg gcaccgggca gccgaagttg aggtcgatgt ggtcggccag gtcctcgtcg
     1621 gcgatcatgc gcgcggcctt gccgacggtg accgggtcca ccccgtacag ctggatggac
     1681 cgcgggcgtt caccggcgtc gaagcggatg agccgcatgg tcttctcgtt gcgctcgacc
     1741 agggcccgcg tggtgatcat ctcgctgacg aacaggccct tgccgccgga gaagtcccgg
     1801 cacagggtgc ggaagggggc gttggtgatc ccggccatcg gcgccagcac caccgggggt
     1861 gtgacgtcgt gcggtccgat cctgagctgc cgtgccacgg tgccttcgct ccggctcttc
     1921 ctgttgcctg tggtgcctgt cgtcgctgtg ctgctggtga ggccaatgga cgcttgcggt
     1981 tacttccggc ccctggcggt gctgcccacc ctggcggcct cctggtcctg cgccttcgcg
     2041 gctcgcaccg ccgcgcactc gccgcaggtg ccgaagatct ccacggtgtg ggccacgtcc
     2101 cggaagccgt gctcggcggc gatggcgtcg gcccacttct ccacggccgg gccctccacc
     2161 tcgacggcct tgccgcagga gcggcagacc aggtggtggt ggtggtcgtc ggtgctgcac
     2221 cggcggtaga cggcctcgcc ctcgtcggtg cgcaggacgt ccacctcgcc agcgtcggcg
     2281 agtgactgga gggtgcggta gacggtcgtc agccccaccg agtcaccccg gtgcttgagc
     2341 atgtcgtgca gctcctgcgc gctgcggaac tcatcgacct cgctcagtgc cgccgacacc
     2401 gcggcgcgct gccgcgtcga acggccgcgg actgggggac ctgcggtcgc caccgttagc
     2461 ctccttacca aacccgtacg ggtgattggg ctcgcctcgg tcgcgcccaa ttgtgccagg
     2521 tgtggcagac gcgtccgggc gcaccggcta tcgccgccta cccaccgcgt accggctccc
     2581 cttccagcat gccggacggc tcgctccggg cggccagccg ggcgcgtctg cgtgcgacgg
     2641 ccggggtgag cgcggccagc acggcgaacg cggcgatggc cagcagcacg atcgtcgccc
     2701 cgggcggcac gtccacgtag aaggagacgg cggtgccgga cagcgcgacc aggacgccga
     2761 gcacgacgga cagcccgagc gtcaccgcga agccgcgcgt cacctgctgc gccgccgcca
     2821 ccgggatcac catcagcgcg ctgaccagca gcagccccac cacccgcatc gccacggtga
     2881 cggtgacggc cgcggtgacg gccagcagca ggttcagcag cttcaccggc agcccggtga
     2941 cgcgggcgaa ctcctcgtcc tggcagacgg cgaacagctg ccgccgcagc ccgaggcaga
     3001 tcgccagcac cgcacaggac agcacgacga tggcggtgac gtcctcgggc gagacggtcg
     3061 tgatggagcc gaacatagcg gtgagcagat cgccggtgga gccgcccggc gccaaattaa
     3121 tgatcatgac gccgcccgcc atgccgccgt agaacagcat ggccagcgcg atgtcaccgc
     3181 gcgccttgcc gtaccagcgc accagctcga tcgcgacggc gccggccgcg gcgaccagca
     3241 ccgccgtcca caccgcgttc gtgctgagca ggaagcccag tgccacgccg gtgagcgcga
     3301 tgtgcccgat cccgtcgccc atgatcgcct ggtgccgctg cacgaggtag atgccgacgg
     3361 cgggcgcggc gatgcccacc agcagcgcgg ccagcagggc gcgctgcatg aaggcgtagt
     3421 cgaggatctc gatcatgacg gaagccctgt tccgatgcgg ggggccacgg gggcctcggc
     3481 ggggacggcg ctgtcgtgcg ggtggcaggc cagatcgtgc agctgctcgg ggtgctcaac
     3541 gcgctccacc cggccgtcgc gcaggacgac gctgcggtcg atcagcggcg ccagcggccc
     3601 cagctcgtgc agcaccagga gcaccgaggt gccctcggac acctgcgccc gcagcgcggt
     3661 ggccagcacc cgctggctgg ccaggtccac cccggccagc ggctcgtcca tgatcagcag
     3721 ctcgggttcg gcggcgagcg cgcgggcgat gagcacccgc tggtgctggc cgccggagag
     3781 cgcgctgacg gagtcccggg cccggtcgcc caggccgacg aggtccacgg cgcgggtgac
     3841 ggcgtcccgg tccgcgcggc ccagcgggcg caggcggcgg cgggcgagcc gtccggagga
     3901 gaccacctcg cggacggtcg ccgggacccc ggcggcggcg gtcgaacgct gcgggacgta
     3961 gcccaggcgg tgccaggccc tgaagcggcg cagcggcgtg ccgaacacct ccagctcacc
     4021 gccggtcagc ggcacctggc cgatggcggc gcggacggcg gtggacttgc cggagccgtt
     4081 cgcacccagc agggccacga cctcgccgcg tcctacggtg aggtcgatgc cgcgcagcac
     4141 gggccgcgcc ccgagcgccg cgtgcacgcc gcgcagggct atgacgggat cggtcgcggg
     4201 ttccgtcacg gatgccttca cgggcaggcc ctcctccacc gccccggccg gggcgctcac
     4261 ttggcgccga gcgccttttg cagtgcttcc aggttcgcgc gcatgaccgc gaagtagtcg
     4321 tcgccacggg aggcgtcggt gatgccttcc agcgggtcga ggacgtcggt gtccaggttc
     4381 aggtcggcgg ccagggcctt ggcggtgcgg tcgctggcga tcgtctcgaa gaacaccgtg
     4441 gagacgttgt cctcctcggc gatggtgtgc agctccttca gccgcgcgcc actcggctcg
     4501 gtctccgggc tcagcccggt gatgggctcc tggtgcaggc cgtagcgggc ggcgaggtgg
     4561 ccgaaggcag cgtgagtggt gatgaaggtg tccgtcgcgg tgttgctcag gccctgctcg
     4621 aactcggtgt cgagctgctc cagctcggcg gacagctcgt cggcgttctt gcggtagtcg
     4681 gcggcgtggt cggggtcggc cttggccagc gcctcgccga caccctcggc gacggcagcg
     4741 tactgcacgg ggtcgagcca gatgtgcggg tccttgccgc cgtggtcgtg gtcgtggtca
     4801 tgctcgtggt cgtggccctc gtgcgcgtcc tcctcggtgg gctcgtcact ggcgggctcg
     4861 tccccggtgg gctcaccttc gccgtgctcc tcgccgtggc cgtgctcgcc gtgctcctcg
     4921 ccgtggccgt ggtcgccgtg ctcctcgccg tggccgtggt cgccgtgctc ctcgccatgg
     4981 ccgtgctcgc cgtgcccgtg gtcgtcgtgg cccgcgtcgc cgtggttctc ctcgtccggg
     5041 ccgtggtcgg tccggccgcc ctgcggctcg gcaccgccac cggctgcagc ctccgccagc
     5101 gcactggcct ccacgacgtg ctcggccccg gactgcttga tcgcgtcgtc caccgcgggc
     5161 tgcataccct tgaggtagag cacggcaccg gcctcggtca gctcggcggt ctgccggggg
     5221 gtgagttcca ggtcgtgcgg atcgacgccg ggctgggtca gcgtcgtcac cgagacgtgc
     5281 tcaccgccga cccgctcggc caggaactcc atggggtaga aggaggcgag gacggacagc
     5341 ttgccgtcct ccgtggtccc cgcgctcccg ctcccacagg cggacagggt gagcagggac
     5401 agcacggagg ccccggcgag tgcggggccc gctatgagag ggcggcgacg agcgttcatg
     5461 acactcattt tcagcaataa tggaaaccgt tgtcaaattc gaacgcaggt gcgctccggc
     5521 cccgcgtggc cgcacggggc agccccgcac accgatttga tccggggcat gcccacgccg
     5581 gtaatctgag gtattccgtc gtcgtttcgt aacgaagaga gcaccgtggc cgccgacaag
     5641 atcgacacca tcgtcagcct cagcaagcgc cgtggcttcg tctacccgtg cagcgagatc
     5701 tacggcggtc agcgggccgc ctgggactac ggtccgctgg gcgtcgagct gaaggagaac
     5761 atcaagcgcc agtggtggcg cacgatggtc acctcccggg aggacgtcgt cggcatcgac
     5821 tcctcggtga tcctggcgtc cgaggtgtgg caggcgtccg gtcacgtcgc caccttcacc
     5881 gaccccctga ccgagtgcac ctcctgccac aagcgcttcc gcgccgacca cctggaggag
     5941 gcgtacgagg ccaagcacgg ccgcctgccc gagggcggcc tggccgacct caactgcccc
     6001 cactgcggca acaagggcac gttcaccgag cccaagcagt tctccggcct gctctccacc
     6061 cacctgggcc ccacccagga ctccggctcg gtcgcctacc tgcgtccgga gacggcgcag
     6121 ggcatcttca ccaatttcag ccaggtccag cagacctcgc gcaagaagcc gccgttcggc
     6181 atcgcgcaga tgggcaagtc cttccgcaac gagatcacgc cgggcaactt catcttccgc
     6241 acccgcgagt tcgagcagat ggagatggag ttcttcgtca agccgggcga ggacgagcag
     6301 tggcacgagt actggatgga gcagcgctgg aactggtacc gggagctggg cctgtccgag
     6361 gccaacatgc gctggtacga gcacccggcc gagaagctgt cccactactc caagcgcacc
     6421 gctgacatcg agtaccggtt cagcttcggc ggctcggagt ggggcgagct ggagggcgtg
     6481 gccaaccgca ccgacttcga cctgggcgcg cactccaagg cgtccggcca ggacctggcc
     6541 tacttcgacc aggaggccgg agagcgctgg acgccgtacg tcatcgagcc cgccgccggt
     6601 gtgggccgca cgatgctggc cttcatgctg gacgcctacg tcgaggacga ggcgcccaac
     6661 gccaagggca agatggaaaa gcgcaccgtg atgcggcttg acccgcgcct ggcaccggtc
     6721 aaggtcgccg tcctgccgct ctcccgcaac gagcagctgt cccccaaggc ccggggcctg
     6781 gcccagacgc tgcgcggcca ctggaacatc gagttcgacg acgcgggcgc catcggccgc
     6841 cgctaccgcc gccaggacga gatcggcacc ccgttctgcg tcacggttga cttcgacacg
     6901 ctcgatgaca acgcggtcac cgtccgcgag cgcgacacca tgaagcagga gcgtgtctcc
     6961 ctcgaccagg tcgagtccta cctcgcctcc cgcctcatcg gctgctgacc cctgcgggac
     7021 gccgcaccga caccagcgag ccgtggtacc tgcccccgtg ggggcgggca ccacggctcg
     7081 ctcgcgttta ccgctgcggt ggcgcctgcg ccgagagctc gttcgggatc gcgccgccga
     7141 agcggcggtc gcgcttggcg tactccaggc acgcgcgcca caggtcgcgc cggtcgaagt
     7201 cgggccacag cacgtcctgg aagaccatct cggcgtaggc gctctgccag atgaggtagt
     7261 tggacgtgcg ctgctcgccg gagggccgca cgaacatatc gacgtccggc atgtcgcggt
     7321 agtagaggta cttggcgaac gtcttctcat tcaccttgcc cgggtcgagc cgcccggcgg
     7381 ccacgtcgcg ggcgatggcc tgcgcggcgt cggcgatctc ggcgcggccc ccgtagttga
     7441 cgcagaagta cagcgtcatc gccgtgttgc gcttcgtctg ctcctgcgcg gtctgcaact
     7501 cctggacgac cgacttccac agcttcggca tgcgccccac ccagcggatg cggatgccca
     7561 tggcgtccat ctcgtcgcgg cgccgccgga tgacatcccg gttgaagttc atcaggaagc
     7621 gcacctcctc gggcgagcgc ttccagttct ccgtcgagaa ggcgtagagg gagaggttcg
     7681 ggatgccgat ctccaggcag ccgcgcagca cgtccagcac gacgccctca cccatgcggt
     7741 gcccctcggt gcgcggcagc ccgcgctcct tggcccagcg gccgttgccg tccatcacga
     7801 tggccacgtg gttcggcacc agttcggcgg ggagctgcgg cgggcgggcc ccggaggggt
     7861 gcggtgcggg tgcggcgtag ccgcgggaag cgtggggctg ccgggacagc atgttcaact
     7921 ccagatgagg tcgccaggaa caggcccgag ggtatccgct cagccttttt cgacgtaccg
     7981 cagggaacgc agcccgcgct ccaggtgcca gtgcaggtac gccgacacca gcccgctgcc
     8041 ctcgcggacg tggcggggct cggcggcgtc ggcggcgggc cagtcaccgg tcagcagcgc
     8101 ggccagcagg cgcagcgcct ccggcgaggg cacgacactg ccggggcggc ggcagtccgg
     8161 gcagacgcag ccgcctccgg ccacggagaa gaaccggttg gggcctggca tgccgcactg
     8221 ggcgcaggcg tcgaaactgg gcgcgtagcc gccgacggcg agcgaccgca ggaggtaggc
     8281 gtccagcacg agccccgggg cgtgcgcgtc ggcggccagc gtgcgcagcg cgccgaccag
     8341 cagcaggtac tgctggacgt tgggctcgcc ctcgtggtcg gtgaaccgct cggcggtctc
     8401 cagcatcgct gtgcccgcgg tgtaacgggc gtagtcggtg acgatgccgc ggccgtaggg
     8461 ggcgatggtc tccgtctgcg tgcacagcgg caggccccgg cccaccaggt cgctgccccg
     8521 ggcgaagaac tgcacgtcca catggctgaa cggctccagc cgggcgccga acttcgactt
     8581 cgtgcgacgc acaccccggg cgacggcgcg gacgcgacca tggccccggg tgagcacggt
     8641 gatgatgcgg tccgcttcgc ccagcttctg ggtgcgcagc acgatgccgt cgtcgcggaa
     8701 caggctcatg cggcccattg tcccgcaccg ccgacacctc ccctcccgcc cctgcccccg
     8761 gccggggtgg ggtggggtgc ccgcatccgg ggcggggaca ccccggccct tcgctgcccc
     8821 accgtgacgg cgtgcggtca gcaggcccgg tccgcactgt cgcgtctccc ttccgtctca
     8881 gcccaggccg tccgcgagag ggggctccag aagctcacgg agcgcaacct cggccttgtc
     8941 cacgccctcg gaaacgacct gcatgtgcgc ttgcggcagg ccacccacac cgagccctga
     9001 cgcggtaacg gcggctcgaa gtctctgccg ctgttcactg gtcaggtgtg accgcgctgt
     9061 gtggtgagcg aggacttcgc gggccgcata ggcgtcgagc ctggctgcat cggcgagggc
     9121 atcgcagaga gacgccaggc aggcgtcggc ctggccacac gtcagatcga gcgcggcaag
     9181 tcccactcgg gtctgaaagg ccgctgtcga ggattcaggc ggcgtgagca gcgtcagcgc
     9241 ttcctgcacg gcgcggtcca gctccggcgc cggggctcct tcggagcggc agcagatgcg
     9301 caggagcgcg gcgatggcgt tctcccacgg ttccgtggga acggcggagt cgatcgcgtc
     9361 gcgcgcctgc tggtcgagac cgcgttccag caaggacatg atcatgattt ggcgaccgtc
     9421 gaggagacgg ttgccgatgc cacggtgtgc ggtcatggcg tcggcggcct cggtccagcg
     9481 gccgatgcgt gccagagcgc gcgcgccgtc cacgagcaga gtcacccaca gctcctggca
     9541 gatcctgcgg tggtctgcct ccgtacggat cagggccgag aggtcgatgg tgttgccgtc
     9601 gatcacggtg gtggcgcgtt gctgggcagc gcggtagagg cgggtgagga catcgtaggc
     9661 ggtgtggccg tcgccgttcc tgatcagcag ccgagagatg ttgatcaagg gcatcagtga
     9721 catgacggcg acgtctcccg gcaggtgcct ggcgtcggcg aagacccggt gctgtctcca
     9781 gcacagctcg gcggccaggc cgggcatccc gacgtcggag acgatcagcg cgccgtagtt
     9841 gaggactccg caggcgcggg ccaccaggtc acggtgtccc gcgcctgcgg gcgcgacggt
     9901 cagcccggtg aggtgggtaa tgcgctcgtc cagcgggagc gcgggtgcct tggagcgctt
     9961 gaccaggggg atgcggctgg ctatcgcggg aatcaccggg tcagcccttg cgtggccagt
    10021 caacgatgag acggctgtag ggcttgtcga tgacgaagcg cgggtcggcg gccgtcaact
    10081 ggtcacgggc gtcgccgact gccatgcgga agcccggttc gggcgcggca tttccccagc
    10141 cctcgtccca ggtgcggatc tcggtgacga accggtcggc gaggtcggcg ccgccggggc
    10201 cgtgcccgat gacaccgacc tcccagaagc ggccagcctc gtcctcgcct tcccggatcg
    10261 tcaggtacgc cagggagccg ccctccaggg cggccatgga gccccagccg aagtgcgggg
    10321 tgaagccggg gcgggaaccg ggcaggcggg acaggccgtt gggcagcgcg caggccaggt
    10381 acaggtacat ccactcgaac ggggcgccct ggcggagctt gacaccggtg aagatcttgg
    10441 cctggggcgt gtccagggcc gtgcggagcg cgtcgcggtc cacgtcctgc tcactgaagg
    10501 tctccaggcg gacgttgccc tcgccttcca tgggcacgag ggtgcagacg tcgtcgcaga
    10561 cgcccttgcg cagggggatg aaggtgcaca tctcgcagga aacggtcttc caggtgtcgc
    10621 cgtcgcgctc gaaggcgaag ctgcggctga tgctgccgcg gatgcgcatg ggcaggacga
    10681 gacgtccgtt cggggccaac tggtcgagga gcttggccgg gacgtcgccc gcgcccacgg
    10741 tgaactggat gcggtcatag ggcgcgtgct cggggagacc ggcggctccg tcggccagta
    10801 cagcggtgac gttggtggcc ccggcccggg cgaggttctt gttcgcaccg tcgatgaggt
    10861 cttgatcgac gtccagggtc cacacctgcc cggtggggcc gacgagtttg cccagcaggt
    10921 tcgcgttgta gccggtggcg gcgcccgcct ccaggacctg gtggccaggc tggacgtcga
    10981 gctgttcgag ctgggtggcg acgatggacg gtgcggagat gcaggagatc atctcgccgt
    11041 gctcgtcgtg cttgatgggc acagcttcct ccttatacgc cacttcccgg tctacggagg
    11101 ggaggaaggt gtggcggtcg gtggcacgga acgcgccgat gatgacggag gtgcgcaggt
    11161 ggccgctttc gacaaggcgg tccgccaggg cttcgcgcgg ttcagcggga tcggtgacgg
    11221 gcgtcacggt ggtctccatt cgagggaggt cagggtccgg cggggtggac cggcgggtag
    11281 agacgggcgt gtcagctgtt gtggagaagg cgacttggcg gcccagccac gcggtggcgg
    11341 cctgctcagt gacaggcacc ccggcacggt tgaaggcgaa gatcgcgtga tgggcgagga
    11401 cggcgcgcaa gccacgtatc agttgtccat cggtggcgag tcggcgtaga cgccgaccgg
    11461 catccgcgaa ggcggcgacg cggtcggccc agcccgcctc cgcgtccggg cggcgggcgg
    11521 cgtcggcgtt catcagacgc cgcatggcgg ccacggaacg gtcgagtgcg ggcacggctg
    11581 gcgcggtgac ggaggggcgc agggcggcga actgggacca gacgtccccc acctcgaagg
    11641 ggtccagccc ggcggcgcgg ttcagcacgg acagcagcat gacgcagcgc tcgcggtttc
    11701 cggtgctgcc ggtctcgggc agggcgctgc ggctgtcggc gcagaacacg tcatgggcca
    11761 cgtccatgcc ctcggtgccg ccgaaagcct cggcctccgg ctcgtagacg ccgccgaccc
    11821 acccggtgat gtaccgctcg gcagcgaggc ggtccagcag ggcaacggag ggacgttcgg
    11881 tgcgcaggcg cagccccgcg tccttgcgca agaagtggaa tcgcgtctcg tgcagtgcgg
    11941 ccgacagagc gtgggcggcc tcgggggtca cggtgccgcc cgggaaggcc acgctggcgt
    12001 gccaccaggt cgtgtcgtgg gcgatcggta ggttttcgtc gtcgtcgaag gtcatacgtg
    12061 tgggcgctcc tcgtcagcgg ggcgggatca ggtgatcagc agcacggtgg tccagtgcgt
    12121 ggcgttcgtg ccgtcgagag cgagctgcgc gccgctgcgg ccctccatga agccgggttt
    12181 ggacagccgg ttcaggtcgg tagccagacg ccggagcaga tcgctgatga ccggtaggaa
    12241 gcgctcaggg gtcgggctgt cagcggcgat ggcgcgggcg acggtcagca ggccggccca
    12301 gccgtggcac agcgtggcgt cggtgatccg ggcgagctgg gcgggctcgg tgagcgtctg
    12361 tacgagggcg tcttccgctg cctggcgccg ggccggatcg cccaaggcga gcgcggcaag
    12421 ctgttgggcg cgggccatgc cgggtaggcc gtagcaccag gacgggcggg caggccccgg
    12481 ctcaggcggc tcggctgcgt caaggtgggc gcgggtggtc cagtagtggc cgccataccg
    12541 gtccagccag cgggcgaaga cctcaattgc ctcgtgctgg cccgggacga agtggccctg
    12601 cctggctgcg agggagagca ccgtcagggg cccggcgatg ccgtgcgcca caccattgtt
    12661 gccgtgcccc cggcccgctc ctcaccgcca ggccgacagg ggaccaccac cccgggagtt
    12721 tttctcctcc gaagcagacc ggccacgaga gagccacgag gtagttcagc acgctggtca
    12781 gccgcgacga gggtgtcgta cgactcagga gcagcgctcc cagtcctgtc aggccacgaa
    12841 tgtggtccca ttccgcgagg tccggcaggg tccccgaggt ctgccgccgc cgcgctgcgg
    12901 ccaggcgtgc gtccaccact cggttgacag cctcgtggac gtcggaaccg gcgtgtccgg
    12961 cacgggtcag cacgaactcc agggcagggg ccccgtggaa caggctcgcg ttgccacccg
    13021 cactcacccc gtgggcgaca ccctgcgcga ggtgatggcg cgcggcagcc atgtcgcctc
    13081 gctcaatgtc cagcagggcg agccccaaag gcccctcgga gaggtcctgc gtgcggggcg
    13141 ggaacctcgc ggccgtcacg tgcggaccgc caggggaagg acgaggctgt gcgcccggcc
    13201 gttgatccac ttgtcggcgt ccggcggcgg cgcctcttgc agagtggcga cgccgatggg
    13261 gctggcgtcc aggtgggcgc gcaacagatc gaggtgcatg tcctggctca ggtcgagagg
    13321 aagctgttgg tcgtcttcgg ccagcagcac gcggttgggc acggtgaacc ggctttgcca
    13381 agcgtggagt tgctcggccc actccttcgc ggtcgcggtc cggccgggca gttcccgggc
    13441 gcgcaccttc caccgagcga cggtgaggat ggttcgccgg taggtgaggg ccggggtgaa
    13501 gggcagggtc caggccacgc cccagtcgaa ccaggtgacc tgcggtgcga gggcccgact
    13561 gatctcgccg aggaaccggg ccatcggggg cgtgtagttg ttccacagga agttgatcgc
    13621 ggtcggcgcc aagagctcca ggcaggtgcc ggtagcgatc tccaccaggc gggggcggcc
    13681 gtcacggacg ctgacagcca ggtcggaagg gaacagcacc ccgtcgccag ggcggcggaa
    13741 ctcaccgacg ctgacgatac ggggcagcac gtgcggggcg cgggtaagca ggtctgccgg
    13801 gacgcgtccg gcgtggaagg agagctgggc cagctcggcg ccgggctcga tcgtgggcag
    13861 gtccgtgtac gtcgtgccgg tctcggggaa caggtgccaa aaccgccccg tcattgaacc
    13921 ggccgaccgg gagacggtga ccacccgcag gcggaagttc cctcgttgca gtgcctcgga
    13981 cgaggcggcg tggatgtggg cggccagttc gatgtgtggc gcggtgagcc ggggcttctc
    14041 acccgccgcc tccaactcct cgatcatcgc gccggtcagg ggcaccgagc gagcgccttc
    14101 gacggccgcc gtgccggcca gttccagcaa cagccggtca cggtgggaca tagggcgggg
    14161 cggctcggcc gccttcacga agccgtcggg gaaaccgatg ccctggcagg ggtcggtcgc
    14221 cacctccacg ggaactgcgg tgttctcgcc gtaccggtcg gtgaactgct cagcccagcg
    14281 gcgccagggc ggggtgccgt tggggtgcgt ggcgagccgg gccagcaccg tcgcggccgt
    14341 ctccgcctcg gtcaggacct cctgcggcaa ccgcacctcc gcgtcaagcc gcagatcagc
    14401 ggccgtcgca cggtcacgca cctgcgcacg cagcactggc gggaggactt gggccgggtc
    14461 aacgacggtg gccggggcac gcagcgacga ccacagcagc cgcaccctca gcaactcggc
    14521 gaggagctgc ctgcgggctt ggccggaggt gtcggggaat tcagcagcga gcttgtccac
    14581 caggagggag tagcggacgg gggttcgtgc cgcgtccaac acgaacctga gcgcggggct
    14641 gctcagcgcg aggcggaact cagcgtcgcc ctccgacggc acacggactc gtccgtcacg
    14701 ctgccgggca agcggatgga cacagacacc agcgtcggcc atccgcgtgc catctgcttc
    14761 ccaagcactg atcgcctcgt caagctccac cgggtcgggg cgggtgaccg cctggtgccg
    14821 gtcgccgaag cggacactcg ccgtgtcccc gaactcgacc agtgcgacgc cagcgaacag
    14881 gccgtagggg gtggaccggc gcgtataccg gatcgcgtac cgggccgtag ccagtgccgc
    14941 ccggcggact cggcgcagct tcggggcaca gccgtcgagg atcgcctgca cctggtgggc
    15001 caggtccggg ctggcggagg acaccgcctg ctggaagttc tcatcggccc acacggtgcc
    15061 cagccacgaa cgccactcgt ctagcgaggc cgagcgccca ggccagggcg ccatgaccgg
    15121 ctcggtaagg tgcgctgccg cgcgcagcat gccttgcccg gtgccttggt acaggcggtg
    15181 tcgtgcgcgt gtcatcacca ctccgttctc ggtgggcggg aggcgcggtc cggacaggct
    15241 gccgtccgga ccgcgctgcc gagctgcctc ggcttacgag gtgacgcaag cgctcgggca
    15301 ggagctgccg caggtgtcac cggtgctgca catcaggacc gtttcggtcg ccggtgtgcc
    15361 ctcgatgaag gtgatgtcaa ggccgaaggg gtccggctgc gcttcgacgc tggggacggg
    15421 ggccgtcgcg gtggccaccg ctgtggactc gctcatctgc gtacctccta catgtgtggc
    15481 caactgccac tcttacaggg gttgttgacc tcttacggtg tgttgccaaa cgatcgcccg
    15541 caagtgggcg gtcccgcacc ggcagtcgcg ctatcggcag gtgccggggc gggagctcat
    15601 cgggccgtgg tctggccacg gctgttgttg tcgcggagca gtgctttagg cgccgcatgc
    15661 acgactcaca ggcgcaggac cccgtgccag tctccggcta gccccaagtc ctctacggcc
    15721 ttcaactcgg cggtgacggg accgaacgtg ctccagtgct gccggaaatc cgtgtgttcc
    15781 tggcctaggg cgctcgccgc cgtcgcggcc atccgccgag cctcggccgc ctcatccggc
    15841 cggttgttgc gcaccgccgc cgaggcgatc cacaaggaca gctcacccca tgcggctagc
    15901 tcactgaccg tcgcggagga catacgcggc tccatctggt cggccgtcac ggctgccagc
    15961 ctctcggact cgtcgaaccg gtcctgacgc agcagcagcc agcacattcc actcaccccc
    16021 gtggcggccc acgctgtgtc attcacctcc cgcgcgagcc ggatgccctc agacagagcg
    16081 tgataggcca tgtcgtactg ccgcacatgc gtcaggtgct ttccggcgaa cagcagggcg
    16141 tgggagcgga cgcgcattgc ctcctgccgg tcggtgtcgt cctctgcgga ggccactgcg
    16201 gcctcagtcg cgcggagcag gcccggcagc gttctggcca cggagtcgta ccggtcggcg
    16261 aagtggagcg tatgcccctc gccgacctgc cgccacagct tcgcgagcgg ttccgcccca
    16321 cctgggtctg tcagcgtttg cctgatccca accggtggca tgagcgcttt cctgagcgtc
    16381 atgagcatct gccggttcgc ctcatcaccg atgaccggtt ccggagaatc cgctgcgaac
    16441 agcgctgacg tagggatgtt cagggcacgg gcaaggcagt gcagggtctc caccctcgcc
    16501 tggccgccct gctcgacctt tctgaccacc gatacggaaa gaccggcatc gttcgccagc
    16561 tcttcctggc tgagccccgc gacgcgacga tgtgcccgca ggttgtctcc caagcctgat
    16621 gacggatacg gcataaccaa ctccgttctg acctcgacct cagaaacggt aactccgatc
    16681 tgcgccccga ctgtgatgca tcccataggg cgcgggtcgg ggttctacca caccctcttc
    16741 ccgggaacct ggtcgccagc caggccctat ggacggtgcg cggcggcagc cgggccgcag
    16801 cgcgcagctc ggccagtggg cgcaccggcc cgtcctcggg aaggtcgtag gtggacaggg
    16861 tcgtggacag ctgcggcatc gcagcgtgca cccactgctc ggtgcggccc ggtcctggtg
    16921 gagctttgtc gggtcactgg cgagcgcatc cgcgagggca tccaggatcg gagcgttgtg
    16981 ccatgtgcgc cgcgttcgat cttccgcagg gggccgacgt gaatgccagc catgtcagcg
    17041 agctgccgct gagtcatgcg tgcgatcacc ggaagtaaac aactcgtttg cccagctccc
    17101 tgtttgacag gctctcgggc atgctggctc cagttcgggg cgaccacccc agacagtacc
    17161 cagtccgata cgctctgagg gcgcggttgg gtgaagtgcc ccactgctga tgaggcagtt
    17221 cgcttacccg cgcacgatcg cggcgaggtc gtgcagagaa tcgattcggt aatccgaggc
    17281 ttcgcggacc ctggggtcgt cggcccatag gtgcccgtac gggccgcgtc gaagatgcgc
    17341 cgtcatcagt ccggcctcgc gggccgggaa gacgtccctg ggagggtggt cacccacata
    17401 gaggacctgc ccggggtcgg agacgtccgc aaggtcaacg acgcgcagga agaactccgc
    17461 gctcggcttg gccacacccc actcccccga cgtggccacg gcgtccaccg gcagctttag
    17521 ccctcgaagc tccctcccgg caacgcgcgt ctggttcccg gccgcgacca cccgcactcc
    17581 ggcctctcgc agcgcggtga gggccgggcg gacatcgtcg tagagatcgg actcctccag
    17641 ccgctcaccc agcccggcag cctcccgcgc cgcgtactcg gcctccaggt ccacgccggg
    17701 cttcaggagg cgtacggctt ccgcgttgtc ccgcccctgg gccacgactg ccccgaccaa
    17761 cgcggagagg gtgtgccggt cgatgccgag ccagtccgcc cacgacgccc agtagcgggt
    17821 gtcgtgcgtc agcgtctctc cgatgtccaa tgctatggcg cggatcatga cgggacccta
    17881 tctacgacac ccgcgtcgcg ggtagcacgt cccaccctga ccgtggccgc agaggttgcc
    17941 ccgctcccgg aggcttggag cggccatccc cagtgcaggg cgggcacctg aggccgcgag
    18001 tcgccgcgta ctcagagccc ggcggccggg gcaccgcgcc acggagctgc ccgggccggg
    18061 aaggcggagg tcccggccgg ggctgtcgga ggggccgggg gctactccgc cgcgtggagt
    18121 acgcgggtga tcagggctga ttgggcgggc gtgaggcggg ggtcggcgca gtaggtcgtg
    18181 gtgtcgtcgg cgatgatctc gtaggagaag ccctccgggc cgcccaccgg cggcgtctcg
    18241 tggccctcgg ccagcgccgt gcgggccagc tcggtgagtt cggtgtcggt cgtgtcgagc
    18301 gcggcgcggc ggggctgccc gccctgaccg ccggtgcgga tgacggtgat gtgcatatcc
    18361 ccacggtagt cgagccgtca cgttcagcgc ccgcgcggca ggtctcgcat actgaaacag
    18421 gggcagcgag agggcggacg ctcggttagg gtgcggtcat catgcgtttt gggctgcttc
    18481 tccttagctg ccgcggcgag ggcctgtagt cgaggccgac cccctccccg cggagttcgg
    18541 tgctgccacc gtcggcctgc gaagccctct tggcgatcgg agcccacacg tcatgacgat
    18601 ttcctcttca cagccggtag gccgtgccac gcccgtcacg gcggcgtccg tggcgcagcg
    18661 gccctcgggg atgccgatcc acaagtacgg cccctacgag tcggtggaca tccccgaccg
    18721 cacctggccg aatgcccgga tcaccaaggc gccgcgctgg ctgtccaccg acctgcggga
    18781 cggcaaccag gcgctgatcg acccgatgtc gcccgcccgc aagcgcgaga tgttcgacct
    18841 gctggtgggc atgggctaca aggagatcga ggtcggcttc ccctcctccg ggcagaccga
    18901 cttcgacttc gtgcgctcga tcatcgaaga gggcgcgatc cccgacgacg tgacgatctc
    18961 ggtgctgacg caggcgcggg aggagttgat cgagcggacg gtggagtcgc tggtcggcgc
    19021 accgcgcgcg acggtgcacc tgtacaacgc gacggcgccc gccttccgcc gcgtggtgtt
    19081 ccggggcacc cgcgagcagg tgcggcagat cgcggtggac ggcacgcggc gggtgatgga
    19141 gtacgccgac aagctgctgg acgcgcggac caccttcggc taccagtaca gccccgagat
    19201 cttcaccgac accgagctgg acttcgcgct ggaggtctgc gagtcggtga tggacgtctg
    19261 gcagcccgag gagggccgcg agatcatcct gaacctgccc gccaccgtgg agcgctcgac
    19321 cccgtccacg cacgcggacc gcttcgagtg gatgtcgcgc aacctgtcgc gccgcgcgtt
    19381 cgtctgcctg tccgcgcacc cgcacaacga ccggggcacg gccgtggcgg cggccgagct
    19441 ggcggtgatg gccggggccg accgcgtcga gggctgcctg ttcggccagg gcgagcgcac
    19501 cggcaacgtg gacctggtga cgctgggcat gaacctgttc tcccagggcg tggacccgca
    19561 gatcgacttc ggccagatcg acgagatccg ccgcacggtg gagtactgca cccagatgga
    19621 ggtacacccg cgccacccgt acgccggtga cctggtctac acggcgttct ccggctcgca
    19681 ccaggacgcc atcaagaagg gcttcgacgc cctggaggcg tcggccgcgg cggccgggaa
    19741 aaccgtggac gaggtggtct gggaggtgcc gtacctgccg atcgacccca aggacgtggg
    19801 ccgctcctac gaggcggtca tccgcgtcaa ctcccagtcc ggcaagggcg gcgtcgccta
    19861 cgtcctgaag aacgaccaca acctggacct gccgcgccgg atgcagatcg agttctcccg
    19921 gatcatccag gagaagacgg acgccgaggg cggcgagatc actccggcgc agatctggga
    19981 gatcttccgc gacgagtacc tgcccacgcc cgagcgcgcc tggggccgca tcgcgctgcg
    20041 cagcgcgcag agcgagtcaa cgaccgacgg gcacgacgcg ctgaccgtgg aggccgtcgt
    20101 ggacggtgtg gccacggtgc tgaagggcca cggcaacggc ccgatctcgg cgttcttcga
    20161 cgcgctggct caccacggca tcgacgtgcg gctcctggac tacgtggagc acaccctgag
    20221 cgagggggcg agcgcacagg ccgcgtcgta catcgagtgc gcgatcgacg gcaaggtgct
    20281 gtggggcgtg ggcatcgacg ccaacaccac gcgcgcttcg atcaaggccg tggtctccgc
    20341 cgtcaaccgc gccacgcggt aatggagttg gcgttaccgg acggatagcg ccgcgcgggc
    20401 ccctggccgg agggacacct tccggccagg ggcccgcgtt ttgtccggta cggagggtga
    20461 cgcggagggg agtgtgtggt taacatcacg tcccacggca gcggcaaggc gccggagcca
    20521 tggaggtgcg gtgtgggcgg agcgcgcgcg acacgcaggg cgagccggat gcgcgcgggc
    20581 ctccgcacgg gcgtccgcgt cgcctggacg gcggtggccg acggctcgtt cttctgcccc
    20641 cggtgcggcg gtgaccgcaa ctacgagcgc cgcaccgggc gtcggcggct ggagctactg
    20701 ggcgtgccgc tggtgcgcgg cggggtgacg accccggtgc tggcctgtgc cacctgcgct
    20761 acccacgtca gtccgcaagc gctggagcac ccgacgagca cccggctggc cgcgctgctg
    20821 ggcgacggcg tacgggcggt ggcgctggcg gtgctggcgc tgggcgggac ggagcatccg
    20881 gcggcggtcc gcgcggcggt ggagacggtg cacgcggccg ggtaccccga gtgcaccgag
    20941 gaggagctgc tgtcggcctg cgcggcgctg cggggctacg gggccgacgc cgaggaggcc
    21001 cgcgtcggcg tggagatcgc gctgcacgcc gcactcgggc cgctggtgcc gcacctggcc
    21061 gcgccggggc gggcgagcct gctggtgcgg ggcgcccgcg tcgcgctcgc cgacggcccg
    21121 tacctcccgg ccgaacgcgc ggtgctggcc tcgctgggga gcgcgctgga actgtccgcc
    21181 ggggagatcg acgccctcct cgcggcagcc cccgaacgcc gctgacgcgg gccggggccg
    21241 aaacccacca gcacgcccgg agagcacggg ccgggggtca aaagcccagg cggcgaagct
    21301 gcttggggtc gcgctgccag tccttggcga ccttcacgtg caggtcgagg aagacgggcg
    21361 tgcccagcag ggcctcgatg tgctggcggg agcgggtgcc gacctccttc agccgcttgc
    21421 cgccggggcc gatcacgatg cccttctggc tcggccgttc gatgtagacg ttggcgtgca
    21481 cgtccagcag tggccggtcg gccgggcggc cctcgcgcgg cagcatctcc tccaccacga
    21541 cggcgatgga gtgcggcagt tcgtcccgca cgccctccag cgcggcctcg cggatcagct
    21601 cggcgaccat cacctgttcc ggctcgtcgg tgaggtcacc gccggggtag agcggggggc
    21661 tctgcggcag catcggcacc agcaggtccg ccaggagtga cacctgggtg ccgtccttgg
    21721 cggagacggg cacgatctcc gcccactcaa agcccagctc ccggcccatc cggtccacgg
    21781 cgagcagctg ctcggcgagc gccttggagt ccaccagatc ggtcttggtg acgacggcga
    21841 ccttcggcgt gcgcttcagc tgcgccagct ccccggcgat gaagcggtcg ccggggccgg
    21901 tcttctggtc ggcggggagg cagaagccga tgacgtccac ctcggcccag gtggtgcgca
    21961 ccacgtcgtt gagccgctcc cccagcagcg tgcgcggctt gtgcaggccc ggggtgtcca
    22021 cgagcacgag ctgcgcctcg ggccggtgca cgatgccgcg cacggtgtgc cgggtggtct
    22081 gcggccggtt cgaggtgatc gcgaccttcg tgcccacgag tgcgttggtc agggtggact
    22141 ttccggcgtt cgggcggccg acgaagcagg cgaagccagc ccggtgcggc gtgggagaag
    22201 ggtcgctcat gcgccccatt ctccctgatc gcccgcgcgc tcccgaacgc cccggcggtc
    22261 cggcggtccc gaccgcccgt cggggacggc agtccgtcgg ctctggcccc gccggtcccg
    22321 gcggtccgtc gcgggcggcg gtcccggcag tccgccggtc ccggcggtcc ggcggccctg
    22381 gcagctccac ggcgccgggc gcgcctgggc tccggctgcc gctcggtccc gggccgtgcg
    22441 ccgtcagccc gcggtgaggg tggtgcgcac ggtgccgtcg ggtccggcga ggaggacggg
    22501 cgtggtgccg cccaggtcgg cgacggccgc gaggtcggcg tccgccagtg cctcggcctc
    22561 ggtgacgacc gcgcccgctt ccagcgaggt cgcgccggag gccacggcca tcgcgacggc
    22621 ggtgcgcagg gcggacagct ccagcgaggg caggccgacg gtggcggcga cgtaggtgcg
    22681 gcccgtctcg tcgcggacgg cggcaccctc tgccacgccg ttgcgggccc gcgcgctgcg
    22741 cgcgagcacg atgatcttgc ggtcctcggg gtcgatggcg tgggcttcag tcatgcccgt
    22801 gagcatacgc aggcgcgact gccgtgcggc gcccgggaag gaccgcgcgg gcaccggcgg
    22861 gcgggcgggg tgcggtgggc gggttacgcg ccgtcggcgg gctcggcgtc gcggggtgcg
    22921 gagacccgtt cgaccaggac gcggtcgatg cggttgcggc ggcccgccgt ggactcggcg
    22981 gtcaggcgca ggcccgcgag cgtcgggtcg gccgggtccc cggacaggtc ggcgaccgcg
    23041 cgggcaccgg cgatcggcac ccggccgagc agcttggcga gcaggccgcc gacggtctcc
    23101 acgtcctcgt cgtcgtagtc ggccagcccg tacagctcgc cgaggtcatc gaggctcagg
    23161 cgggcggtga cgcggtagcg gccctccccc agctcctcca ccggcggcag ctcgcggtcg
    23221 tactcgtcgg tgatctcgcc gacgatctcc tccaggatgt cctcgatggt gacgatcccg
    23281 gccgtggagc cgtactcgtc gatgacgacg gcgacgtggt tgcgctggac ctgcatctcg
    23341 cgcagcagat cacccgcgtt cttggtgtcc ggcacgaagg cggccgggcg catggtggtg
    23401 gctaccagct ccgactcggc ctcgcggctg atgtgcacct tccgcgccag gtccttgagg
    23461 tagacgatgc cgacgacgtc gtcctcgttc tcgccaatga ccgggatgcg ggagaacccg
    23521 gagcgcaggg ccagggtgag ggcctggtgg atcgtcttga agcgttcgat ggtcaccagg
    23581 tcggtgcgcg gcaccatgac ctcgcgcaca agggtgtcgc cgagctggaa gacggagtgc
    23641 accatgcggc gctcctcgtc ctcgatcagc gactcggact ccgcgaggtc caccatggcc
    23701 cgcagctcgg cctccgaggc gaacgggccg cgccggaagc ctttgcccgg ggtgagcgcg
    23761 ttgcccagca ggatgagcag ctgcggcagc ggcccgagca cccgggccag cggcagcagc
    23821 acgtacgcgg cggccgtggc ggtgttcagc gggtgctgga tgccgatggt gcgcggtgag
    23881 acgccgacgg cgacgtagga gaccagcacc atcacggcga tcgcgacggt gatcgcctgc
    23941 caggtctggt cgaaggaacg cacgcacacg taggtgacga ggaccccggc ggccatctcg
    24001 ctggcgacgc gcagcagcat cgcgaggttg aggtagcgca ccggctcggc ggcgacggcg
    24061 gcgagcttgg cgctgccgcg ccggccgctg cgcacggcct gctcggcgcg gaagctggtg
    24121 gtgcgggcca ggccggcctc ggcgcaggcg gccagccagg ccagcacgat gagggcgacc
    24181 gcgaaggcga tgagcgttgt catggtgggt ggggtcgtgc gggtcaggtg acggtggggg
    24241 ccggggaggg gccggtgagg ccgtgctcgt cccgccagcc gtccacgatg gcctgctgga
    24301 ggccgaacat ctcggcgcgc tcgccgggct cctcgtggtc gtagccgagc aggtggagca
    24361 ccccgtgcac ggtcaggagc tggagctcct cgtccatggt gtgcccggtg ggggcctgct
    24421 cggcctggcg ggcggcgacc tcggggcaca gcacgatgtc gccgagcaga ccctgcgggg
    24481 gctcgtcgtc gtccttgccc ggcgggcgca gctcgtccat cgggaaggac atcacgtccg
    24541 tgggccccgg caggtccatc cactgtgtgt gcagctgctc catggcctcg gtgtccacga
    24601 tgatgaccga cagctcggac agcgggtgga tgcgcatgcg ggtcagggcg tagcgggcga
    24661 tgtcgaggat cgcctgctcc tcgacctccc gcccggattc gttgttgacg tcgatggaca
    24721 tgtgcggtct ggctgctctt tcctcgggac cgggcggggc ggacgcagcc taccgggcgc
    24781 cgccggggcg cgccgcccgc gcgccggtca ccggccggtg ccgccgtcgc gaccggcggc
    24841 gcgctcaccc gggctgtggc cggagcggcc ggaggggact ccagggcggc caggacggtt
    24901 accggggcgg gccgggcggc cctcggtgtg gtcgccgtcc cggttgtcgt agcggtcgta
    24961 ggcatcgacg atgcggccga cgagcttgtg ccgtacgacg tccgtgctgg tcagccgggt
    25021 gaagtggacg tcctcgacgc cgtcgaggat ctcctgcacc tggcgcagcc cggacttggt
    25081 gccgccgggg aggtccacct gcgtcacgtc gccggtgatg acgaccttgg agtcgaagcc
    25141 gagccgggtg aggaacatct tcatctgctc ggggttggtg ttctgggcct cgtcg
//
