LOCUS       NZ_JAEVFI010000001     11455 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Streptomyces sp. JJ66 scaffold1_size460382, whole genome shotgun
            sequence.
ACCESSION   NZ_JAEVFI010000001
VERSION     NZ_JAEVFI010000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. JJ66
  ORGANISM  Streptomyces sp. JJ66
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 460382)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Draft genome of Streptomyces sp. JJ66
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 460382)
  AUTHORS   Jose,P.A. and Jha,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-JAN-2021) Marine Biotechnology and Ecology Division,
            CSIR - Central Salt and Marine Chemicals Research Institute, G.B.
            Marg, Bhavnagar, Gujarat 364002, India
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 25-MAY-2017
            Assembly Method                   :: Velvet v. V 1.2.10
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 320.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019303495.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 03:51:48
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,515
            CDSs (total)                      :: 4,446
            Genes (coding)                    :: 4,340
            CDSs (with protein)               :: 4,340
            Genes (RNA)                       :: 69
            rRNAs                             :: 1, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (23S)
            tRNAs                             :: 61
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 106
            CDSs (without protein)            :: 106
            Pseudo Genes (ambiguous residues) :: 0 of 106
            Pseudo Genes (frameshifted)       :: 31 of 106
            Pseudo Genes (incomplete)         :: 82 of 106
            Pseudo Genes (internal stop)      :: 3 of 106
            Pseudo Genes (multiple problems)  :: 9 of 106
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:22:12
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 147149
            Orig. end                         :: 158604
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAEVFI010000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11455
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11455
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11455
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6455](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6455)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(2..16)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.12"
                     /tool="antismash"
     gene            complement(198..1958)
                     /locus_tag="JJV70_RS00660"
                     /old_locus_tag="JJV70_00660"
     CDS             complement(198..1958)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016828015.1"
                     /locus_tag="JJV70_RS00660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00660"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_219045501.1"
                     /transl_table=11
                     /translation="MTSTAAIPAAPAPRGALRALLPALAAHRMMALRTLLAALAEHASL
                     AALVTLAAHTVGTALLAGAPPGPGTVAVLVALVAVRALATWREMDLSHDLAYRVLALLR
                     VRAFDGLARSAPARVAGRRSGDLAATAMADVEALEFFYAHTTAQLLASTAVFASGGMVL
                     AAVEPWLLAAVVPAALLLVGAALLEGRGRAARGARTRGAAARLSADTVDTVDGLRELLG
                     FGALGRRRALLAARGRELGRAQRAEAGWEAAASALREAVVVGAVLAVVAVTAHAVTSGQ
                     LAGPWAPAAMALALSVLAPVADSAQALAQAAGLRAAAARVGAAVRAPALAPPPASPVPV
                     PDGPLGLRLRDVRFGYGGRAVLDGLDLTVPAGQTLALVGASGAGKSTCAHLLARLWDPE
                     SGTVELLPGRGAALDLRQLADADLRRAVAVVGQDAPLFHGTLADNLRLAAPDATDAEVA
                     DVARRTGVERVAEGLPDGLESLVGERGATLSGGQRARVALARALLGAPRVLVLDEATAH
                     LDTASEAELAAALADGAGTRTTVVIAHRPATIRRADRVAVLADGRVAEHGTWAELTARN
                     GALHRLLDRG"
     gene            complement(1955..3688)
                     /locus_tag="JJV70_RS00665"
                     /old_locus_tag="JJV70_00665"
     CDS             complement(1955..3688)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="JJV70_RS00665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00665"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_219045502.1"
                     /transl_table=11
                     /translation="MLIHPELRAAARTAPRPLLAATALLGALALTHVAQAVLLAFALAA
                     VARGATAHLPPLLGGVLALVLLRAALTWWQRRTAARAGARVRVRLRDALLARLGALGPA
                     YLTGARAGAVRTTLVDGVEGVDAYISRYLPQLLVTCLTPPLLLAAVAAVQPAALLGLVP
                     ALALALLGPRAWDRLLARRGAEHWDTYEALGADYLEALQGMPALRAAGAVGRTRARLER
                     RSAALHRATVAKLRVSLADTALTDLAVQGGTVAAALLACWSAATGATAATGTYLLLLLA
                     SECFRPVRDLAREWHAGYLGASAADGLAALRTARPAVTDTGTAHPRWPRPPEVTFDRVR
                     LTYPGSSHPALDGVSFTAPAGRTTAIVGPSGAGKSSLLALLLRQREPQGGRVLLDGHDV
                     AEYTVDALRRGIAVVSQDTYLFHATVADNLRLADPGADAAALEHAARTAGVHDEIAALP
                     EGYATVLGERGATLSGGQRQRLALARALLADAPVLVLDEATSAVDEHREARVTRALLKA
                     VRGRTCLVVAHRLAAVRHADHIVVLDGGRVEAAGDHRGLLADSAVYARLVTAGQVRGLA
                     A"
     gene            complement(3692..4990)
                     /locus_tag="JJV70_RS00670"
                     /old_locus_tag="JJV70_00670"
     CDS             complement(3692..4990)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017947323.1"
                     /locus_tag="JJV70_RS00670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00670"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_308294617.1"
                     /transl_table=11
                     /translation="MSFVPFAPPPGPPAPPASHRETPPPGAPIRSEDPGLSAHPGLSAF
                     PGLLARARSAEIPGPDTSPGPRVTAWPGPARRLPHARPGQVDLSGHLRLSLAALDARGR
                     LRPVPSAGACHPVDVRLTAGSAAPLAPGRYGYDPLRHRVHWLGPAPAGAPPGVRVELTV
                     TARRTTAHYGHRAWPLLLLDTGHAAAGLQLAARALGAPEAVVTLDAGTRDAADRAADGA
                     GSRTLAARGVGDEPGPAPLASVYLPPPGTWRRGEPAQPPAQLLGRRSAPPPLAGAPDAG
                     ALAAVLACAQRAGGGLLTWCAAVGAPEPGLVTHAPGGQLRRLARGDARPTLAAWAAGQG
                     WLAGAGAIVLAVGAPDDADAEHLCRAHLTAGHAAGLALATAARHGLRTRPVGSWQRADL
                     GAALGDPPGRQWVVHGLALAAPAPRTPPETLEP"
     gene            complement(5001..6455)
                     /locus_tag="JJV70_RS00675"
                     /old_locus_tag="JJV70_00675"
     CDS             complement(5001..6455)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613007.1"
                     /locus_tag="JJV70_RS00675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00675"
                     /product="YcaO-like family protein"
                     /protein_id="WP_219045503.1"
                     /sec_met_domain="YcaO (E-value: 9.6e-53, bitscore: 174.5,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTAPPPATAPTAPPGPGAAPEPSAPALPLEALVDPVCGIVRAV
                     APVEHPAGAPPRYTAMTAEVADARRLGAWPADRVSLGTTFGDADGARVAAIAEAVERYC
                     GNRVPPPGHRDAPLAATAAQLTEQGRRLYGPADLPRYAPWQYARPGFPYRPLTDDTPAL
                     WARGTEHLPDGSTAECWAPVSLTHLNWRQGELRAYPRTHHLNYAGIATGQGLDDAVERG
                     LLEIVERDALELWWHLDGPARGIDPDSVPGLRDDLAGSGLRVWLVEMASEFAPCLAALV
                     HDPERGLYAAGFACRYDPAQAARKAVLEAVHTWVFTQGLTGPDGWVFQAVEAGLLARGL
                     YLDHRPDARYLDACGPDLAAVRDLGAHVQVWLDPRMAAEARRFTAPALGTVPVDALEPG
                     SRARLWDRLHTGGHRVVSVDVTTEDVAHTPLRVARVLASGLVPNAPAAFAYLGCPRFAD
                     AALARGWREAPPSAPADFTLVPPPHM"
     gene            complement(6452..8107)
                     /locus_tag="JJV70_RS00680"
                     /old_locus_tag="JJV70_00680"
     CDS             complement(6452..8107)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512968.1"
                     /locus_tag="JJV70_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00680"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_219045504.1"
                     /transl_table=11
                     /translation="MTAAARTPVAAPPPGPARGTGASRTHARVRTAHLPAPDGTPLATD
                     ICLPATPGPHPAVLIRTPYDRRAHRPELRGWAARGFAALAQDVRGRHGSPGTWRPYHGE
                     AADGAPTVRWVRSQPWSDGRLLAAGASYAAHCALALALDPDPTGGPSGPGTPDAVLVAV
                     PALDTAHTAREPSGPERLLGRAGWWAAHGDRPDSDENALARALDADPALLHHLPLTTLP
                     DRLARPLPSWPGVWSPTRRGRLLDAAPTARVPLLAVGGTHDPFAAETVTLWRRWTGAPA
                     RLLLGPWGHRLTADPGADAHPKHRLPLGEAYVSWARAALDGRLDAAPRGAVGLGGSPLW
                     LPAPAHPGEPSARYGFGRPTGLRLLGAAHFTADPRHPVRSDDLAVPRPPGPRSGDAHPD
                     ASADRCLLVTAPLPRPLDLLGTARVRLRACADTPCADWVARLVALAPDGAAAPLATGVV
                     RRHDPPGRPADLSVPLGPLARRLPAGTRLRLEIAGHHFPAHARNPHTGEDPVTATVLHP
                     SRRTLRTEHCALLLPVSRTCGFTAAVDPLQEISR"
     gene            complement(8104..8973)
                     /locus_tag="JJV70_RS00685"
                     /old_locus_tag="JJV70_00685"
     CDS             complement(8104..8973)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015613004.1"
                     /locus_tag="JJV70_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00685"
                     /product="hypothetical protein"
                     /protein_id="WP_219045505.1"
                     /transl_table=11
                     /translation="MTRSQLAPGVEVVAVPGDRLALRTADGAFLRVETGEADVADLLAR
                     LAGTGPGATADADAEPELARLLEAFEAAGYLTSRADVPPPPRAWPAHRREVLLLGDAAL
                     TEPLAACLTTAGAAPRTGTRAELGTTRAAAVVWCLNGPVPEGLWDDADELPARGIAWLR
                     CHREGHQLWLEPPAAAPGDVTSAQVRARRLAATPAYRELAAYWSGHRTTGAPVTLTAPA
                     AACAAALLAADLTAWATGTTAPQPTGTLPAARRLRSLDVRTLTVSEHPVLPVPPVAAPL
                     TAPSGERT"
     gene            complement(9108..9221)
                     /gene="amiA"
                     /locus_tag="JJV70_RS22335"
     CDS             complement(9108..9221)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004115.1"
                     /locus_tag="JJV70_RS22335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_257573115.1"
                     /transl_table=11
                     /translation="MEQEKVFAPIADPGQLAHASASHSNALVENPFDDNEE"
     misc_feature    9286..9299
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 10.75"
                     /tool="antismash"
     misc_feature    complement(9287..9301)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.38"
                     /tool="antismash"
     misc_feature    9292..9307
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 24.15"
                     /tool="antismash"
     misc_feature    complement(9294..9307)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.33"
                     /tool="antismash"
     misc_feature    complement(9294..9308)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: strong, score: 26.44"
                     /tool="antismash"
     misc_feature    9295..9308
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.48"
                     /tool="antismash"
     misc_feature    complement(9295..9310)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.66"
                     /tool="antismash"
     misc_feature    9298..9313
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.29"
                     /tool="antismash"
     misc_feature    9300..9314
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.31"
                     /tool="antismash"
     gene            complement(9306..10142)
                     /locus_tag="JJV70_RS00690"
                     /old_locus_tag="JJV70_00690"
     CDS             complement(9306..10142)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="JJV70_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00690"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_308294618.1"
                     /transl_table=11
                     /translation="MSKVTTGTTEPPPGVRVEGVHFGYPGRPVLHEVGLTIAPGELTAL
                     IGLNGCGKSTLLRLIAGLLRPTRGRVLLGDADLARLSRRAAARRVALLHQSAPPVPGMT
                     VRQLVRQGRYAQRGPLGMLRDGDGRDDDAVRRALADTGVAAWAQRPVDALSGGERQRVR
                     LAMALAQDTRVLLLDEPTTYLDLRHQLEVLQTVVRLRAERGLTVVMVLHDLAHAARFAE
                     RIVALRDGRVVADGPPKEVVTSELLADVLDVAGRVGQDPEGGWPVCYPDHPLTAST"
     misc_feature    complement(10200..10214)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 15.41"
                     /tool="antismash"
     gene            complement(10226..11233)
                     /locus_tag="JJV70_RS00695"
                     /old_locus_tag="JJV70_00695"
     CDS             complement(10226..11233)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010048297.1"
                     /locus_tag="JJV70_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJV70_00695"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_219045506.1"
                     /transl_table=11
                     /translation="MTARFTALGGLVALVAVASLLAGRAVTPGAVVDVLAGGGGDTARH
                     VVLNLRLPRLLVALGAGAALGVAGLVLQSALRNPLAGPEVTGVTPGAVLGAVAATGLGV
                     AGWQSPAAVVVAACVGGFTGAGLLWLLAGRERGDAATTAVYGVLVSAVLGGLTAMVLLV
                     APGQLGSVVQWLVGSTEGRVWAHWNLLWPWTLAWGTGAWLLAAPLTLLRLGDEPAAAVG
                     LEISRARAVALLCAVALTAGAVSSVGALGFVGLLVPHLAVALFGADLRRTLPGAALCGA
                     VVVCGADAVAQLASRWLSSALDAGRLTLPVGALTTGLGAALLLAVVRRAPGRSF"
     misc_feature    complement(11218..11232)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 14.96"
                     /tool="antismash"
ORIGIN
        1 catcgacacg ctggaggcgt tcctcgactc cgacggctcc tggacgcggt gcgccgcccg
       61 cctgcacctg cacgtcaaca ccctgcgcta ccgggtgggg cgcatcgagc agctgaccgg
      121 ccgcgacctg tcccggctag aggacaagct cgacttcttc ctggccctgc gcatcagctg
      181 acgccccctc gctgtggtca gccacggtcc agcaaccggt gcaacgcgcc gtttcgggcg
      241 gtgagttccg cccaggtgcc gtgctcggcg acgcgcccgt ccgccaggac cgccacgcgg
      301 tcggcccgcc ggatcgtcgc gggccggtgc gcgatgacca ccgtggtgcg cgtgcccgcg
      361 ccgtccgcca gcgcggcagc cagctcggcc tcggaggcgg tgtccaggtg cgcggtggcc
      421 tcgtccagta ccagcacccg tggcgcgccg agcagggccc gggccagcgc gacccgggcc
      481 cgctggccgc cggagagcgt cgcgccccgc tcgcccacca ggctctccag cccgtcgggc
      541 agcccctcgg cgacgcgctc gacgccggtg cgccgggcga cgtcggccac ttcggcgtct
      601 gtggcgtcgg gcgcggcgag ccgcaggttg tccgcgagcg tgccgtggaa cagcggcgcg
      661 tcctggccga cgacggccac cgcgcgccgc aggtcggcgt cggccagctg gcggaggtcc
      721 agcgccgcgc cccgcccggg cagcagttcc accgtgccgg actccgggtc ccacaagcgg
      781 gccagcaggt gtgcgcaggt ggacttgccc gccccggagg cgccgaccag cgcgagcgtc
      841 tgcccggccg ggacggtgag gtccagcccg tccagcacgg cccggccgcc gtagccgaac
      901 cgcacgtcgc gcagccgcag cccgagcggt ccgtccggca ccggcacggg tgacgcgggc
      961 gggggcgcga gggcgggagc ccgcacggcc gcccccaccc gggccgccgc cgcccgcagc
     1021 ccggcggcct gcgcgagcgc ctgcgcggag tcggcgaccg gcgccagcac ggacaacgcc
     1081 agcgccatcg cggccggggc ccacggcccg gccagctggc cggaggtgac ggcgtgtgcg
     1141 gtgaccgcga cgacggccag tacggcgccc accaccacgg cctcccgcag cgcggaggcc
     1201 gccgcctccc acccggcctc ggcacgctgc gcgcggccca gctcgcgccc ccgcgccgcc
     1261 agcagcgcgc gccgtcggcc gagcgcgccg aacccgagca gttcgcgcag cccgtccacg
     1321 gtgtccacgg tgtcggcgga caggcgggcg gcagcgcccc gggtgcgggc accgcgcgcc
     1381 gcccgccccc gcccttccag cagcgcggcg cccaccagca gcagcgcggc cgggacgacg
     1441 gccgcgagca gccagggctc gacggcggcg agcaccatgc cgccgctggc gaacaccgct
     1501 gtcgaggcca ggagttgggc cgtggtgtgg gcgtagaaga actccagtgc ctccacgtcg
     1561 gccatggcgg tggcggccag gtcaccgctg cggcgcccgg cgacgcgggc gggggcgctg
     1621 cgcgccagcc cgtcgaaggc gcggacgcgc agcagggcca ggacccggta ggcgaggtcg
     1681 tgcgagaggt ccatctcccg ccaggtggcc agcgcccgga cggcgacgag cgcgacgagc
     1741 acggccacgg tgcccggccc cgggggcgcc ccggccagca gggcggtacc cacggtgtgg
     1801 gcggcgagcg tcaccagcgc cgcgagcgag gcgtgctcgg cgagtgcggc gagcagggtg
     1861 cgcagcgcca tcatccggtg ggcggcgagc gcgggcagca gcgcgcgcag cgcgccacgc
     1921 ggcgcggggg cagccggtat cgcagcggtg gaggtcatgc ggccagcccc cgtacctgtc
     1981 ctgcggtcac gagccgggcg tagaccgccg agtcggcgag cagcccgcgg tggtccccgg
     2041 cggcctccac ccggccgccg tccaggacga cgatgtggtc ggcgtgccgc acggccgcca
     2101 gccggtgcgc gacgaccagg caggtgcgac cgcgtaccgc cttcagcaga gcgcgggtga
     2161 cgcgggcctc gcggtgttcg tccacggcgc tggtggcctc gtccagcacc agcacgggcg
     2221 cgtcggcgag cagggcgcgg gccagtgcga ggcgctggcg ctggccgccg gagagggtgg
     2281 cgccgcgttc gccgagcacg gtggcgtagc cctcgggcag cgcggcgatc tcgtcgtgga
     2341 cgcccgcggt gcgggcggcg tgctccagcg cggcggcgtc ggcgccgggg tcggccaggc
     2401 gcaggttgtc ggcgacggtg gcgtggaaga ggtaggtgtc ctgggagacg acggcgatgc
     2461 cacggcgcag ggcgtccacg gtgtactcgg ccacgtcgtg tccgtccagc agcacgcgtc
     2521 cgccctgtgg ttcccgctgg cgcagcagca gcgccagcag gctggacttg cccgcgccgg
     2581 agggcccgac gatcgccgtg gtgcgcccgg ccggtgcggt gaagctgacg ccgtccagcg
     2641 cggggtgcga ggagccgggg taggtcaggc gcacccggtc gaaggtcacc tcgggcgggc
     2701 ggggccagcg ggggtgcgcg gtgccggtgt cggtgacggc gggccgggcg gtgcgcagcg
     2761 cggcgagccc gtcggcggcg gaggcaccca ggtatccggc gtgccactcc cgggccaggt
     2821 cgcgcaccgg gcggaagcac tcggaggcca ggagcagcag caggtaggtg ccggtggccg
     2881 cggtggcgcc ggtggccgcc gaccagcagg cgagcagcgc ggcggccacg gtgccgccct
     2941 gcacggcgag gtcggtgagc gcggtgtcgg ccagggagac gcggagcttg gcgacggtgg
     3001 cccggtgcag cgcggccgag cggcgttcca gccgggcacg ggtgcggccc acggcgccgg
     3061 ccgcccgcag cgcgggcatg ccctgcaacg cctccaggta gtcggcgccc agtgcctcgt
     3121 aggtgtccca gtgttcggcg ccgcgccggg ccagcagccg gtcccaggcc cgtggcccga
     3181 gcagggcgag cgcgagcgcc gggacgagac cgagcagcgc ggcgggctgg acggcggcga
     3241 cggcggcgag cagcagcggc ggggtgaggc aggtgacgag gagttggggc aggtagcgcg
     3301 agatgtaggc gtccacgcct tcgacgccgt ccacgagtgt cgtgcgcacg gccccggcgc
     3361 gggccccggt gaggtaggcg gggccgagcg ccccgagccg ggccagcagg gcgtcccgca
     3421 gccggacgcg gacgcgtgct ccggcccgcg cggcggtgcg ccgctgccac caggtgaggg
     3481 cggcgcgcag cagtaccagg gccagcaccc cgccgagcag gggcgggagg tgggccgtgg
     3541 cgccccgggc gacggcggcg agcgcgaacg cgagcagcac ggcctgcgcg acgtgggtga
     3601 gcgcgagggc gccgagcagc gcggtggccg ccagcagcgg acgcggcgcg gtgcgcgcgg
     3661 cggcccgcag ttccgggtgg atcagcatgc gtcagggctc cagcgtctcg ggcggggtcc
     3721 ggggggcggg ggcggcgagg gcgagaccgt gcaccaccca ctggcgtccg ggcggatcgc
     3781 cgagtgccgc cccgaggtcg gcgcgctgcc aggagccgac ggggcgggtg cgcaggccgt
     3841 gccgggcggc ggtggccagg gcgagcccgg cggcgtgtcc ggcggtgagg tgggcgcggc
     3901 acaggtgctc ggcgtcggcg tcgtcggggg cgccgacggc cagcacgatg gccccggccc
     3961 cggcgagcca gccctggccg gcggcccagg cggcgagcgt gggccgggcg tcgccccggg
     4021 cgaggcggcg cagctggccg cccggggcgt gggtgacgag cccgggctcg ggggcgccga
     4081 cggctgcgca ccaggtgagc agcccgccac cggcccgctg ggcgcaggcc agtacggcgg
     4141 cgagcgcgcc cgcgtccggc gccccggcca gcggcggcgg agcgctgcgc cgcccgagca
     4201 actgggccgg tggctgcgcg ggttcgccgc gccgccaggt gccgggtggc ggcaggtaca
     4261 cgctggccag cggcgcgggg ccgggctcgt cacccacgcc ccgggcggcc agggtgcggg
     4321 aaccggcgcc gtccgccgca cggtccgccg cgtcgcgcgt accggcgtcc agcgtgacga
     4381 cggcctccgg tgcgcccagc gcccgggcgg cgagctggag tccggctgcc gcgtgcccgg
     4441 tgtcgagcag cagcaggggc caggcgcggt ggccgtagtg ggcggtggtc cgccgcgcgg
     4501 tgaccgtcag ctcgacccgg acgccgggcg gggcaccggc cggggcgggt cccagccagt
     4561 gcacgcggtg ccgcagcggg tcgtacccgt accggcccgg ggccagcggc gcggcgctgc
     4621 cggcggtgag gcggacgtcc acggggtggc aggcaccggc cgagggcacg ggacgcaggc
     4681 ggccccgggc gtcgagcgcg gccagtgaca gccgcaggtg cccggagagg tccacctggc
     4741 cggggcgcgc gtgaggcagg cggcgcgcgg ggccgggcca ggcggtcacg cgcggcccgg
     4801 gcgaggtgtc aggacccggt atctcggcgc tccgggcgcg ggcgagcagc ccggggaacg
     4861 cggacagccc ggggtgggcg gacagcccgg ggtcctcgga ccgtattggt gctccgggcg
     4921 gcggcgtctc gcggtgcgag gcgggcggag cgggcggccc gggcggcggc gcgaagggca
     4981 cgaaggacac ggcgttcccc tcacatgtgc ggcgggggca cgagcgtgaa gtccgcgggc
     5041 gcgctgggcg gggcctcgcg ccagccacgg gcgagcgcgg cgtcggcgaa gcgggggcag
     5101 ccgaggtagg cgaaggcggc gggcgcgttg gggaccagcc cggaggccag gacgcgggcg
     5161 acccgcagcg gcgtgtgcgc gacgtcctcg gtggtgacgt ccacgctgac gacgcggtgg
     5221 ccgccggtgt gcagccggtc ccacagccgg gcgcggctgc ccggttcgag cgcgtccacg
     5281 ggcacggtgc cgagcgcggg tgcggtgaag cggcgggcct cggcggccat gcgcgggtcg
     5341 agccacacct gcacgtgggc gcccaggtcg cggacggcgg ccaagtccgg tccgcaggcg
     5401 tccaggtagc gggcgtcggg gcggtggtcg aggtagaggc cacgggcgag cagcccggcc
     5461 tctacggcct ggaacaccca gccgtccggg ccggtgagcc cctgggtgaa gacccaggtg
     5521 tgcacggcct ccagcacggc cttgcgggcc gcctgagccg ggtcgtagcg gcaggcgaac
     5581 ccggcggcgt agaggccgcg ttcggggtcg tggacgagcg cggccaggca gggcgcgaac
     5641 tcggaggcca tctccaccag ccacacccgc aggccgcttc cggcgaggtc gtcgcgcaga
     5701 ccgggcacgc tgtcggggtc gatgccccgg gccgggccgt ccaggtgcca ccacagctcc
     5761 agcgcgtccc gttcgacgat ctccagcagg ccgcgctcga cggcgtcgtc caggccctgg
     5821 ccggtggcga tgcccgcgta gttgaggtgg tgcgtgcgcg ggtaggcgcg cagctcgccc
     5881 tggcgccagt tgaggtgggt gagggagacc ggcgcccagc actcggcggt ggagccgtcc
     5941 ggcaggtgtt cggtgccgcg tgcccacagc gccggggtgt cgtcggtcag cggccggtag
     6001 gggaagccgg ggcgggcgta ctgccagggc gcgtaccggg gcaggtcggc ggggccgtac
     6061 aggcgtcggc cctgctccgt cagctgggcg gcggtggcgg cgagcggggc gtcacggtgg
     6121 ccgggcggcg ggacgcggtt gccgcagtag cgttcgacgg cctcggcgat ggcggcgacg
     6181 cgggcgccgt cggcgtcgcc gaaggtggtg ccgagcgaga cccggtcggc gggccaggcg
     6241 cccagccgcc gggcgtcggc gacctcggcg gtcatcgcgg tgtagcgggg cggggcaccg
     6301 gcgggatgct cgacgggggc gacggcgcgg acgatgccgc acaccggatc gaccagcgcc
     6361 tccaggggca gcgccggggc cgacggctcg ggcgccgccc cgggcccggg cggggccgtg
     6421 ggcgccgtcg cgggcggggg tgcggtgctg ctcatcggct gatctcctgt agggggtcaa
     6481 cggcggcggt gaagccgcac gtacggctga ccggcagcag cagcgcgcag tgctcggtgc
     6541 gcagcgtacg ccgggacggg tgcaggacgg tcgcggtgac cgggtcctcg ccggtgtgcg
     6601 ggttgcgggc gtgggccggg aagtggtgtc cggcgatctc cagccgcagc cgggtcccgg
     6661 cgggcaggcg gcgggcgagc gggccgagcg gcacgctgag gtcggcgggg cggcccggtg
     6721 ggtcgtggcg ccggacgacg ccggtggcca gcggcgcggc ggcgccgtcc ggggcgagcg
     6781 cgacgagccg ggccacccag tcggcgcacg gcgtgtcggc gcaggcccgc agccggacgc
     6841 gggcggtgcc cagcaggtcc agcgggcgcg gcagcggcgc ggtgacgagt aggcagcggt
     6901 cggcggacgc gtccgggtgc gcgtcaccgg agcgcggacc gggcgggcgc ggcacggcca
     6961 ggtcgtctga gcgcaccggg tgccgcgggt cggcggtgaa gtgggcggcg ccgagcagcc
     7021 gcagcccggt gggacggccg aacccgtagc gcgcggacgg ctcgccgggg tgcgccggtg
     7081 ccgggagcca cagggggctg ccgccgaggc cgacggcgcc gcgcggagcg gcgtcgaggc
     7141 ggccgtcgag cgcggcgcgg gcccagctca cgtacgcctc gcccagcggc agccggtgct
     7201 tggggtgcgc gtcggcgccc gggtcggcgg tgagccggtg gccccacggc cccaggagca
     7261 gccgggccgg tgcgcccgtc cagcggcgcc acagggtcac cgtctcggcg gcgaacgggt
     7321 cgtgggtgcc gccgaccgcg agcagtggca cccgcgcggt gggcgccgcg tcgagcaggc
     7381 gcccgcgccg ggtgggcgac cacacaccgg gccaggacgg cagcggacgg gccagacggt
     7441 cagggagtgt ggtgagcggc aggtggtgga ggagcgcggg gtcggcgtcc agggcgcggg
     7501 cgagggcgtt ctcgtcactg tccggccggt cgccgtgggc ggcccaccag cccgcgcggc
     7561 ccagcagccg ctccgggcct gagggttcgc gggcggtgtg ggcggtgtcg agcgcgggga
     7621 cggcgacgag gacggcgtcg ggcgtcccgg ggccggacgg gccgccggtg gggtccgggt
     7681 ccagggccag ggcgagggcg cagtgggcgg cgtaggaggc ccctgcggcg aggaggcggc
     7741 cgtcgctcca cggctgggac cgcacccagc gcacggtggg cgcgccgtcg gccgcctcgc
     7801 cgtggtaggg ccgccaggtg ccgggtgagc catggcggcc gcggacgtcc tgggccagcg
     7861 cggcgaagcc ccgggcggcc cagccgcgca gttccgggcg gtgggcgcgg cggtcgtagg
     7921 gggtgcggat gagcacggcg gggtgggggc cgggcgtggc gggcaggcag atgtcggtgg
     7981 cgagcggggt gccgtcgggg gcgggcaggt gcgcggtgcg gacgcgggcg tgggtccggc
     8041 tggccccggt gccgcgagcc gggcccggtg gcggcgcggc caccggggtg cgggccgccg
     8101 ccgtcatgtc cgctcacccg agggggcggt gagcggcgcg gccacgggcg gtaccggcag
     8161 gacggggtgc tcgctgacgg tgagcgtgcg cacgtccaga gaccgcaggc ggcgggcggc
     8221 gggcagcgta ccggtgggct gcggggcggt ggtgccggtg gcccaggcgg tgaggtcggc
     8281 ggccaggagc gcggcggcgc aggcggcggc cggggcggtg agggtgaccg gggcgcccgt
     8341 ggtgcggtgt ccgctccagt aggcggccag ttcgcggtac gccggggtgg ccgccaggcg
     8401 gcgcgcgcgg acctgagcgg aggtcacgtc acccggtgcg gcggcgggcg gctccagcca
     8461 cagctggtgg ccttcgcggt ggcagcgcag ccaggcgatg ccgcgcgcgg gcagctcgtc
     8521 ggcgtcgtcc cacagcccct cgggcaccgg cccgttcagg caccacacca cggccgcggc
     8581 ccgcgtggtg cccagctcgg cccgggtgcc cgtgcggggt gcggctccgg cggtggtgag
     8641 gcaggcggcc agcggttcgg tgagtgcggc gtccccgagc agcagcacct cgcgccggtg
     8701 agcgggccag gcacgcggtg ggggtggcac gtccgcgcgg ctggtcaggt acccggcggc
     8761 ctcgaaggct tcgagcaggc gggcgagttc gggctcggcg tcggcatcgg ccgtggcgcc
     8821 ggggccggtt ccggcgaggc gggcgagcag gtcggccacg tccgcctcac cggtctcgac
     8881 gcggaggaag gcgccgtcgg cggtgcgcag ggcgagccgg tccccgggca cggcgacgac
     8941 ttccacgccg ggtgccagct ggctgcgcgt catacggtct ctccttcgcg gcggtgtgcg
     9001 gtcggcggga caccccccgg tcgcgtcccg ggtcgtgccg ctgggcgggg cccggccggc
     9061 gctgccatga ccggccgggc ccgtgcgggg cttaccccgt gcggggctta ctcctcgttg
     9121 tcgtcgaagg ggttctcgac gagcgcgttg gagtgggacg ccgaggcgtg ggcgagctgg
     9181 cccgggtcgg cgatcggcgc gaagaccttc tcctgctcca tggcgaattc cttcctagag
     9241 agggacagtt ggacgctgcg acacccgttc gaatgccgca cgcacacact aaatgaaaat
     9301 gattgtcatg tgctagccgt cagagggtga tctgggtaac acaccggcca tccgccctcc
     9361 gggtcctgcc ccacccggcc cgccacgtcc aggacgtccg cgagcagttc ggaggtgacg
     9421 acctccttcg gcggcccgtc cgccaccacg cgtccgtccc gcagcgcgac gatccgctcg
     9481 gcgaaccggg cggcgtgcgc gaggtcgtgc agcaccatca ccaccgtcag cccgcgttcg
     9541 gcccgcagcc gcaccaccgt ttgcagcacc tccagctggt ggcgcagatc cagatacgtg
     9601 gtcggctcgt ccagcagcag gacgcgggtg tcctgggcca gggccatggc cagccgcacc
     9661 cgctgccgtt caccgccgga cagcgcgtcc accggccgct gcgcccacgc cgcgacgccg
     9721 gtgtcggcca gcgcgcggcg tacggcgtcg tcgtcgcggc cgtcaccgtc gcgcagcatg
     9781 cccagcggcc cgcgctgggc gtaccggccc tgccgcacca gctggcgcac cgtcatgccc
     9841 ggtaccggcg gcgcggactg gtgcagcagg gcgacgcggc gggccgcggc gcggcggctc
     9901 aggcgggcca ggtcggcgtc ccccagcagc acccggccac gggtgggccg cagcagaccg
     9961 gcgatcagcc gcagcagcgt ggacttgccg cagccgttga ggccgatcag cgcggtcagc
    10021 tccccgggag cgatcgtgag gcccacctcg tggagcaccg gccggccggg atacccgaag
    10081 tggacgccct ccacccggac cccgggcggc ggctcggtgg ttcccgtcgt caccttcgac
    10141 accagcggca cctttctacg cggcacgcgg cacgcggcac gcgccgcccg acacccgaca
    10201 gaacacggaa ctcagaactc agaactcaga acgagcggcc cggggcgcgg cgcaccacgg
    10261 cgagcagcag cgcggcgccc agcccggtgg tgagcgcgcc gaccggcagg gtgagccgcc
    10321 cggcgtccag cgcggacgac agccagcggg aggccagttg ggccaccgcg tccgcgccgc
    10381 acaccaccac cgcgccgcac agcgcggcac ccgggagcgt gcggcgcagg tcggcgccga
    10441 acagggcgac ggccaggtgc ggcaccagca gtccgacgaa gccgagcgca cccaccgagg
    10501 agaccgcccc ggccgtcagc gccaccgcgc acagcagcgc cacggcgcgg gcacgcgaga
    10561 tctccagccc gacggccgcg gccggttcgt cgcccagccg cagcagggtc agcggcgcgg
    10621 ccagcagcca ggcgccggtg ccccacgcga gtgtccacgg ccacagcagg ttccagtgcg
    10681 cccacacccg cccctcggtg ctgccgacca gccactgcac gacgctgccg agctgcccgg
    10741 gcgcgacgag cagcaccatg gccgtcagtc cgccgagcac ggcgctgacc aggacgccgt
    10801 agacggcggt ggtggccgcg tcgccgcgtt cccggccggc gagcagccac agcagaccgg
    10861 ctccggtgaa cccgccgacg caggcggcca cgacgacggc cgccggggac tgccagcccg
    10921 ccaccccgag cccggtcgcc gccacggccc cgagcacggc accgggcgtg acgccggtga
    10981 cctcgggacc ggccagcggg ttgcgcaggg cggactgcaa caccagcccg gcgacaccga
    11041 gcgcggcccc cgcgccgagc gcgacgagca gccgtggcag ccgcaggttg agcacgacgt
    11101 gccgcgcggt gtcccctccc ccgccggcca gcacgtccac gacggcaccg ggcgtgaccg
    11161 cgcgtcccgc gagcagactg gccacggcga cgagcgccac gaggccgccc agcgcggtga
    11221 acctggcggt catgcgtcct cctccgcccg gacggcccgg gtgtgcggcg ccacggtcac
    11281 gcccgcggaa gtccccggcc cgcaccagcg gcgcggcacc cgggcggcgt tccagcggac
    11341 tcgccccgca cgcccgccct ggcgcgcggc tgggtcacgg gtcccggccc gcagcagcgc
    11401 cacccccgcc ggcaccccga gcagcgcggt ccacgcgccg accggggttt ccacc
//
