LOCUS       NZ_CP079114            11368 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. WY228 chromosome.
ACCESSION   NZ_CP079114
VERSION     NZ_CP079114.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WY228
  ORGANISM  Streptomyces sp. WY228
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Volatile organic compounds produced by endophyte Streptomyces sp.
            WY228 mediate plant growth and salt stress tolerance by activating
            hormonal signaling and anthocyanin biosynthesis,
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JUL-2021) Key lab of biotechnology of medicinal
            plants, Jiangsu Normal University, No. 101 Shanghai Road, Xuzhou
            221116, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019287315.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 06:02:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,303
            CDSs (total)                      :: 7,213
            Genes (coding)                    :: 7,059
            CDSs (with protein)               :: 7,059
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 154
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 83 of 155
            Pseudo Genes (incomplete)         :: 99 of 155
            Pseudo Genes (internal stop)      :: 10 of 155
            Pseudo Genes (multiple problems)  :: 36 of 155
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:35:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7872959
            Orig. end                         :: 7884327
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP079114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11368
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="34"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11368
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11368
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6368](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6368
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(542..551)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            1041..1958
                     /locus_tag="KV381_RS34320"
                     /old_locus_tag="KV381_34320"
     CDS             1041..1958
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955796.1"
                     /locus_tag="KV381_RS34320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_34320"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_218787033.1"
                     /transl_table=11
                     /translation="MPEGLTEQVDTSPAKEPGPGVESRAESGAEPGPDVVRAEGLTFGY
                     PGRRVLRGVDLSIRAGELVALIGLNGCGKSTFLKLAAGLLTPSGGRVLLEGDDVARLPR
                     RTAARRVALLHQSAPAVPGLTVRQLVRQGRYAARGPLGMLREGDDEVTSRALADVGVTA
                     WADRPVDALSGGERQRVRLAMALAQDARVLFLDEPTTYLDLRHQLEVLQTVVRLRAERR
                     LTVVMVLHDLNHAARFADRIVALREGRVAADGPPAEVVTRQLLAEVLGVDGRVGIDSEG
                     GWPVCYPDHPLEPLQVLRNENHIH"
     gene            2039..2173
                     /gene="amiA"
                     /locus_tag="KV381_RS36820"
     CDS             2039..2173
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508296.1"
                     /locus_tag="KV381_RS36820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_240805756.1"
                     /transl_table=11
                     /translation="MENNKVFSPIADQGQLAHLSATHSNALVENPFDDAVEADTAGEK"
     gene            2342..3331
                     /locus_tag="KV381_RS34325"
                     /old_locus_tag="KV381_34325"
     CDS             2342..3331
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059073.1"
                     /locus_tag="KV381_RS34325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_34325"
                     /product="hypothetical protein"
                     /protein_id="WP_218787034.1"
                     /transl_table=11
                     /translation="MTRSRLAPGTGIVTAPGAGPVLRTSGGEFLRIDTGGVDAGTLVRR
                     LVGEEAPEEGAHTAELTRLIEAFEEGGHAVAAPPRAPLAGRTVHVLGDPVLTVPVARCA
                     GAEGAEVHETTPDRVAELAGATSGRSADGRVAVVWCLDSPVPEGLWDTADRLPGQGIAW
                     LRCHREGAHVWTEPLASAPGDVTARHVRLRRLAATAAHRELAAYWAGHRTPDTGPHPTE
                     ASAALIAGLLTADLLAWAEAEAEAEAEAEAEAGAGAPLGTGAGAGAGASVGPGGSTRLP
                     PRRRLRRIDLRDLTVTEHPVFPVPDVAPLPAPTRVTAHAEAGTAKARR"
     gene            3328..5004
                     /locus_tag="KV381_RS34330"
                     /old_locus_tag="KV381_34330"
     CDS             3328..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377868.1"
                     /locus_tag="KV381_RS34330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_34330"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_218787035.1"
                     /transl_table=11
                     /translation="MNTRTVYVPTPDGIALATDVCLPDGTRPRPAVVIRTPYGRDAHRA
                     ELRGWAAHGFAALAQDVRGRHGSPGEWHPYRGHEMADGAATVAWVRAQAWSSGEVVAAG
                     ASYAAHCALVTALATADGALLGGVPDAVIAAVPALGLTETAREPGGPERLWARAGWWAA
                     HGDRRDSDPDALARALADDPRLLEHLPIARLADRLAEDLGRQLPSWPRLWADRSRGRIV
                     AQGSAARLPLLAVGGTRDPFAEDTVALWHAWGGPSRLLLGPWGHRLAADPAVPARARVN
                     LGALYVRWARAALAGQLEPTRHGVIALGDSGRWHSTRARSAPRPPSPDGHRDRRTVATV
                     AASRATAEAAVPVRVPPAAPAPSPDAAPVRTVAWPFDSPTGLRLLHGAEFSADPDRPVR
                     SDDLAVPAGGDRADRCLLLSPPLPRPLDLVGAAVARVNATADAPCADWAVRLTALDPSG
                     RADPLAFGIVRHTGPPGEAADITVPLGTLGRRLPAGTRLRAEIAGHHFPAHARNPHTGE
                     DPVTATRLVTSHRTVNPRGSALHLPVVARRRYVEPVPEICR"
     gene            5001..6368
                     /locus_tag="KV381_RS34335"
                     /old_locus_tag="KV381_34335"
     CDS             5001..6368
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="KV381_RS34335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_34335"
                     /product="YcaO-like family protein"
                     /protein_id="WP_218787353.1"
                     /sec_met_domain="YcaO (E-value: 2.8e-43, bitscore: 147.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSALPIETLVDPVTGIIRDVAPVEHPTGAPPRYTAMTADVADAR
                     RLGAWPADRVSLGTTFGDPRGAWIAAVAEAVERYCGNRLPPPGHPQEPRRATAAELAAE
                     GHRLYGPGALPAYAPWQYGRQGFPYAELTDDTPVLWTRAVEDGEPCWAPVALTHLNWRQ
                     GDLRSLTRTHHLNYAGIATGQGLDDAVERGLLEVVERDALELWWHLDGPTRGIDPASVP
                     GLTEDLAGCGLDVHIVEMPSEFAPCVAALVHDPGRGIHAAGFACRYGPAEAARKAVLEA
                     VHTWVFTQGAVDADGWVYRAVEAGMLARGLYLDHRADRRYLDDCGPEFAAVRDLGAHVQ
                     VWLDDRMAPLARRFTEPALGVVPVTGIAPGSRTALDAALATGGHRVITADLTTEDVAET
                     TLRVARVLVSGLIPNAPAAFGYFGCPRFADAALARGWRSRPPAGPEDFTLAPPPHM"
     gene            7054..8517
                     /locus_tag="KV381_RS34340"
                     /old_locus_tag="KV381_34340"
     CDS             7054..8517
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018512966.1"
                     /locus_tag="KV381_RS34340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_34340"
                     /product="nitroreductase"
                     /protein_id="WP_373461183.1"
                     /transl_table=11
                     /translation="MTGPTATPPDAPHPARAKRPASGSDVATGARPAAPGFLRQALADA
                     RSSRVPALSPYVPERPFPWNGQGLPVAGTGATAEGSIDLDRVLRLSLAAPTGTPGRLRS
                     VPSAGALHPVRAHLLLGPGCSLPPGRYAYDPRTHRAHPRGPASADVPRGALVVLTVAAS
                     RTVAHYGHRAWPLLLLDTGHAAAALALAASPALDVRVCLDADAALLSAAAGLPRAPDWQ
                     DAWPGTEPELPLAVVRLVRRGGRSADRGGALSAWAALPHGAAPAPLPGADTAPPRELAA
                     ARHLLDHIARAPEPTGGTWHPAARPKPVTDDVLEARRSAPPGDLNHPPGNDLLARILAT
                     ARTAHPAGPAWTAAAGGPAPALYASVPGRHGLGVRASGDARPTLAHWAARQQWVGTAGA
                     VLLAHGCPEDAPPAAVRSSHLIAGYAVGAAQAHATALGLRSRPIGSWQQADLGAALGDT
                     PGRDWIVHGLALGGGGSAPPSTPQPASPP"
     gene            8597..10336
                     /locus_tag="KV381_RS34345"
                     /old_locus_tag="KV381_34345"
     CDS             8597..10336
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018955801.1"
                     /locus_tag="KV381_RS34345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_34345"
                     /product="ABC transporter ATP-binding protein/permease"
                     /protein_id="WP_030081854.1"
                     /transl_table=11
                     /translation="MMLHPELLRAANTARRPLGLATALLAAVTATHLAQAVLLALVLSR
                     IAQGQTAALAPLLTAVIAIVLVRAGLGRAQRLAAVTAGATVRVGLRDTLLRRLGALGPT
                     AITGARAGAVRATLVDGVEGVDAYISRYLPQSLITCAVPPLLLVAVALVEPYAALALGP
                     ALLLALFGPRWWDRLLARRGKEHWDSYEALAADYLEALQGMPTLRTAGAVGRVRERLER
                     RSAALHRTTVAKLRVSLVDTGLTDLAVQGGTVAAVLVACSSAATGRTAATGTYLLLLLA
                     SECFRPVRDLSREWHAGYLGVSAADGIAALRTAEAAVPDRGTRAAVWKNAPEIRFEDVH
                     FTHPGSTRPALDGVSFTAAPGRTTAVVGPSGAGKSTLVSLLLRQRDPDRGRLTVAGTDT
                     AAYTLASLRRGIAVVSQETYLFHATIAENLRIARPAATDEQLRAAARTAGIDQEIARLP
                     DGYATLVGERGATLSGGQRQRLALARALLADAPVLILDEATSAVDERGQARIVRELTAA
                     GRGRTCVVVAHRLDAVRHADHIVVLDAGRVAAAGDHTTLLAGGGVYASLVAAGRTAQEE
                     RAA"
     misc_feature    complement(10961..10976)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.44"
                     /tool="antismash"
ORIGIN
        1 tggtcgcctg cgcggatctc ttcgccggtc ggggcgtcac ccccgaaggc gtccgggccg
       61 tgctgctcgg ggccggcgac gaccccaccg ccgagcacat cgtgctccaa ctgcggttgc
      121 cccgcctgct ggtggcgctg gtcgccgggg cctgcctcgg agtggccggg ctcgtgctcc
      181 agtcggccct gcgcaacccg ctggccggac ccgaggtcac cggcgtcacc cccggtgcgg
      241 tgctcggcgc ggtggccgcg accggcctgg gcctcgcggg ctgggagtcc ccgacggccg
      301 tggtcgtggc ggcctgcgtc ggcggcttcg ccggagcggg actgctgtgg ctgctcgccg
      361 ggcgggaccg gggcgacccg gaacagaccg ctgtctacgg ggtcctggtg tccgcggtgc
      421 tcgccggact caccgccgtc gtcctcctgg tggctcccgg tgaactcggc agcgtcgtcc
      481 agtggttgat cggctccacg gaaggccgtg tgtggcagca ctggaatctg ctctggccgt
      541 gggccgcctt ctggggtgcg gccgcctggc tgctcgccgg accgctgacc ctgctgcgct
      601 gcggcgacga acaggccgcg gcggcgggtc tggccaccgg ccggggacgg ggcgcggcgc
      661 tcgtgtgcgc ggtggcgctg acggccggag cggtctcggc ggtgggcgcg ctcggcttcg
      721 tggggctgct ggtgccgcat ctggcgctgg cggtgttcgg cgcggacctg cgcatcacgc
      781 tcccgggcgc cgcgctgttc ggtgcggcgg tggtgtgcgg ggcggacgcc gccgcccagc
      841 tgctgtcccg gctgctggcc acggcgttgg aggcggaccg gctgaccctt ccggtcggcg
      901 ccctgaccac ctttgtgggg gcggcgctgc tgatggtcgt ggcgcggcgg agggcggacg
      961 agcgatgacg acggtccggc agggcgccat ggacgtgggc gcggacggaa caacaggggt
     1021 acagcgatga ggagagcggc atgccggaag gcctgacgga acaagtggac acgagcccgg
     1081 cgaaggagcc cggcccgggt gtcgaatccc gggcggagtc cggtgcggag cccggtccgg
     1141 atgtcgtgcg ggcggaaggg ctgaccttcg gctacccggg gcgcagggtg ctgcgcgggg
     1201 tggacctgag catccgggcc ggcgaactgg tcgccctgat cgggctgaac ggatgcggca
     1261 agagcacttt cctcaaactc gccgcaggac tcctgacccc gagcggcggc cgtgtcctgc
     1321 tcgaaggcga cgacgtggcc cggctgcccc gccgcaccgc ggcccgacgc gtcgccctgc
     1381 tccatcaatc ggctccggcc gtaccggggc tgaccgtacg tcagttggtg cggcaagggc
     1441 gctatgcggc ccgggggccg ctggggatgc tgcgggaggg cgacgacgag gtgacgtccc
     1501 gggcgctcgc ggacgtcggc gtcaccgcct gggccgaccg gccggtggac gcgctgtccg
     1561 gtggcgaacg ccaacgggtg cggctggcca tggcgctggc ccaggacgcc cgcgtgctct
     1621 tcctcgacga gccgaccacc tatctcgatc tgcggcacca gttggaggtg ctccagacgg
     1681 tcgtacggct gcgcgcggag cgccggttga cggtggtgat ggtgctgcac gacctgaacc
     1741 acgccgcccg gttcgccgac cggatcgtcg cgctgcgcga gggccgcgtc gccgccgacg
     1801 ggcccccggc cgaggtggtc acccggcagc tgctggccga agtcctgggc gtggacggcc
     1861 gggtggggat cgacagcgag ggtggctggc ccgtctgtta cccagatcac cctctcgaac
     1921 cgctccaggt attgcggaat gaaaatcata ttcattagtg tctgtgctgc ggcacgcacc
     1981 aacgcaccaa cgccgtgctt cacacccatc cgatccgacc gaatggagac tccaactcat
     2041 ggagaacaac aaggtgttca gcccgatcgc cgaccagggt cagctcgccc acctgtccgc
     2101 cacccactcg aacgccctcg tcgagaaccc cttcgacgac gccgtcgagg ccgacaccgc
     2161 gggcgagaag tgagcgaagc ctgccgctga cggcaggttt ccccgcgtag cgcgggggcg
     2221 ggcccgcccg gtgactcccg ggcgggcccg cccttcaccc cgctgcctcg ttccccgtct
     2281 ctccgaggca ccccgtaccc gcccgcattc cgtatcccgt cccgccgcac cggaggatcc
     2341 cgtgacccgc agtcgactcg ctcccggcac cgggatcgtc accgcccccg gagccggccc
     2401 cgtgctccgg acctccggag gggagttcct gcgcatcgac accggcggtg tcgacgccgg
     2461 gaccctggtg cgccggctgg tgggggagga ggcgccggaa gagggtgcgc acaccgctga
     2521 actcacccgg ctcatagagg cgttcgagga gggcggacac gcggtggccg caccgccccg
     2581 ggccccgctc gccggtcgta ccgtccacgt cctgggcgac cccgtgctca ccgttccggt
     2641 ggcgcgctgc gccggggcgg aaggggccga ggtccacgag accaccccgg accgggtggc
     2701 ggaactggcc ggggcgacct cgggccggag cgccgatgga cgcgtggccg tggtgtggtg
     2761 cctcgactcg cccgtacccg aggggctttg ggacacggcg gaccggttgc ccgggcaagg
     2821 catcgcctgg ctgcggtgcc accgcgaggg ggctcacgtc tggaccgagc cgttggcctc
     2881 ggccccgggt gacgtcaccg cccggcacgt ccgtctccgc agactcgcgg ccaccgccgc
     2941 ccatcgcgaa ctcgccgcgt actgggctgg acaccgcacc ccggacaccg gaccgcaccc
     3001 gaccgaggcc tccgccgccc tgatcgccgg gctcctcacc gccgatctgc tcgcctgggc
     3061 cgaagccgaa gccgaagccg aagccgaagc cgaagccgaa gccggtgccg gtgccccact
     3121 cggaactggt gccggtgccg gtgccggagc ctcggtaggg ccgggcgggt ccacccgtct
     3181 cccgccccgc cgtcggctgc gccggatcga cctgcgggat ctcaccgtca ccgagcaccc
     3241 cgttttcccc gtcccggacg tcgcaccgct gcccgccccc acacgggtga cggcccacgc
     3301 cgaggccggg accgcgaagg cacgccggtg aacacccgta ccgtgtacgt ccccacgccc
     3361 gacggcatcg cgctcgccac cgatgtatgc ctcccggacg ggacgcgccc ccggcccgcc
     3421 gtcgtgatca gaacccccta cgggcgtgac gcccaccgag ccgagctgcg cggctgggcg
     3481 gcccacggat tcgccgccct ggcccaggac gtacgcggcc gccacggatc accgggggag
     3541 tggcacccgt accgaggcca cgagatggcc gacggcgccg ccaccgtcgc gtgggtgcgc
     3601 gcgcaggcct ggagcagcgg tgaggtggtc gccgcgggcg cttcctacgc ggcgcactgc
     3661 gcactcgtca ccgccttggc cacggccgac ggagcccttc tcggcggagt ccccgatgcc
     3721 gtcatcgccg ccgtccccgc gctcgggctc accgagacgg cgcgcgagcc tggcggcccg
     3781 gagcggctgt gggcccgggc aggctggtgg gcggcccacg gcgaccgccg cgactccgac
     3841 ccggacgcgc tggcccgtgc cctggcggac gacccccggc tgctcgaaca ccttccgatc
     3901 gcccgcctgg cggatcggct ggccgaggac ctggggcgcc aactgccctc ctggccacgg
     3961 ctctgggccg accggagccg gggccggatc gtcgcacagg gttccgcggc ccgtcttccg
     4021 ctgctcgccg tcggcggcac ccgtgacccc ttcgccgagg acaccgtggc cctgtggcac
     4081 gcctggggcg gcccgtcccg gctgctgctc ggtccctggg gtcaccgcct cgccgccgac
     4141 ccggccgtcc cggcccgcgc ccgcgtcaac ctcggtgcgc tgtacgtacg gtgggcccgc
     4201 gccgcactcg ccggacagct ggagccgacg cggcacgggg tcatcgccct cggcgacagc
     4261 gggcgctggc acagcacgcg ggcgcgcagc gctccccggc ctccgtcgcc ggacggccac
     4321 cgcgaccgcc gcacggtcgc caccgttgcc gcgtcccgcg ccacggccga agccgcagtc
     4381 cccgtacgcg tcccacccgc tgcgcccgcc ccctccccgg acgccgcccc ggtccgcacc
     4441 gtcgcctggc ccttcgactc gcccaccggc ctgcgactgc tccacggcgc cgagttcagc
     4501 gccgacccgg accgccccgt gcgctccgac gacctcgccg tcccggccgg cggtgaccgc
     4561 gccgaccgct gtctgcttct ctcgccgccg ctgccgcgcc cgctcgacct ggtgggagcc
     4621 gccgtcgccc gggtcaacgc cacggccgac gccccctgtg ccgactgggc cgtacgcctc
     4681 accgcactcg acccgtccgg ccgcgcggat ccgctcgcct tcggcatcgt ccggcatacc
     4741 ggcccgcccg gtgaagccgc ggacatcacc gtgccgctcg gcacgctggg ccgtcgactg
     4801 cccgccggaa cccggttgcg ggccgagatc gccggacacc acttccccgc ccacgcccgt
     4861 aacccgcaca ccggcgagga cccggtcacg gccacccggc tcgtcacttc ccaccgcacc
     4921 gtgaaccccc ggggcagcgc cctccacctg cccgtcgtcg cccgacgccg ctacgtcgag
     4981 cccgtaccgg agatatgccg ttgaccagcg ccctgcccat cgaaaccctc gtcgatcccg
     5041 tcaccgggat catccgggac gtcgcacccg tcgaacaccc cacgggcgcg ccgccccgct
     5101 acaccgcgat gaccgcggac gtcgccgacg cccgccgtct gggcgcgtgg cccgccgacc
     5161 gggtctcgct cggcacgacg ttcggcgacc cccggggcgc gtggatcgcc gcggtggccg
     5221 aggccgtcga gcgctactgc ggcaaccgcc tcccgccacc gggccacccg caggagcccc
     5281 ggcgggccac cgccgccgaa ctcgccgccg agggccaccg cctctacggg ccgggcgcgc
     5341 tgccggcgta cgccccctgg cagtacggcc ggcagggatt cccgtacgcc gaactcaccg
     5401 acgacacacc ggtgctgtgg accagggctg tcgaggacgg ggagccgtgc tgggcgcccg
     5461 tcgccctgac ccacctcaac tggcgtcagg gcgacctgcg ttcgctgacc cgcacccacc
     5521 atctcaacta cgcgggtatc gccaccggac agggcctgga cgacgccgtc gagcgcgggc
     5581 tcctcgaagt cgtcgagcgg gacgcgctgg agctgtggtg gcacctggac ggacccaccc
     5641 ggggcatcga cccggcgagc gttcccggac tcaccgagga cctggccggc tgcggtctgg
     5701 acgtgcacat cgtggagatg ccctcggagt tcgccccgtg cgtggcggct ctcgtgcacg
     5761 atcccgggcg cggcatccac gcggccgggt tcgcctgccg gtacggcccg gcggaggcgg
     5821 cccgcaaggc cgtgctggag gccgtgcaca cgtgggtgtt cacgcagggc gcggtggacg
     5881 ccgacggctg ggtgtaccgg gcggtggaag ccggcatgct ggcccgcggc ctctacctcg
     5941 atcaccgcgc cgaccggcgc tatctcgacg actgcgggcc cgagttcgcg gccgtccggg
     6001 acctcggcgc ccatgtccag gtctggctgg acgaccggat ggccccgctc gcccgccggt
     6061 tcaccgagcc cgcgctcggc gtcgtccccg tcaccgggat cgctcccggc agccgcacgg
     6121 cgctggacgc cgcgctcgcc accggagggc accgggtgat caccgcggac ctcaccacgg
     6181 aggacgtcgc cgagaccaca ctgcgcgtcg cccgcgtcct ggtctccggc ctgatcccca
     6241 acgcacctgc ggccttcggc tacttcggct gcccgcgctt cgcggacgcg gcgctcgccc
     6301 gggggtggcg atcccggccc ccggccggcc ccgaggactt caccctcgcc ccaccaccgc
     6361 acatgtgaag gagcgtggcc catgcccgac acaccggacc gaaccgccgc gcctgcttcc
     6421 ggggcaggcg tcgcgcagcc caccgcacct gcctcggcga cgcctgccgt gcagcctgac
     6481 ccgcctgctc ccggggcggg cgccgagctg ccggacgcgc ccgcggcgga ggcgtgcggg
     6541 gcaggggcgg cggggtccgt tccgaggacg cccggtgtgt cgcccgtcgc tcccgccgcc
     6601 ggggcgtgcg cggtcgggcc gacggggtcc gttcccggga cgctcggtgc gttgcctggc
     6661 gctcccgtgg ccggacccga gtcggcacgg ccgaccgcgc acgccctcgg ggcgcgtgcc
     6721 atgccgcccg ccgtgcccgc tcccggggtg cgggtcgcgc cgcccgacgt gcgggctgcc
     6781 ggggtgcggg tcacgccgcc gggcctgccg gctccggggg cgcccgccgt ttcgcctgtc
     6841 gcccctgccg tcggaccggt tcccgcgtgt cctgtcgcat ctgcctccgg aacatctgcc
     6901 gcgccgcgcg gcctgcctcc ctccggcgtg cgcgctgtgc cgcccgcacc cggaacacgt
     6961 tccgcgcggc ccgatacggg cggccccgga gtgcatgccg cacggaccac cgcccacgtt
     7021 ccaggggagc ccgccgtgcc atctgctgcc cgcgtgaccg gcccgaccgc cacgccgccc
     7081 gacgcccctc acccggcccg ggccaagagg ccggcttccg gtagcgacgt cgccaccggg
     7141 gcccggcccg ccgcaccggg cttcctgcgc caggcgcttg cggacgcccg ctcatcgcgt
     7201 gtccccgccc tctccccgta cgttccggag cgtccgttcc cgtggaacgg ccaggggctg
     7261 cccgtggccg ggaccggagc cacggccgag ggctcgatcg acctcgaccg cgtgctgcgg
     7321 ctgtcccttg ccgcgcccac cggaacaccc ggcagactgc gatccgttcc ctcggcgggc
     7381 gccctccacc cggtgcgcgc ccacctgttg ctcggtccgg gctgctcgct gccgcccggg
     7441 cgttacgcct acgacccgcg cacgcaccgc gcccacccgc gcggcccggc ctccgccgac
     7501 gtgccccggg gcgcgctcgt cgtcctcacc gtggctgcgt cccgtaccgt cgcccactac
     7561 ggtcaccggg cctggccgct gctgctcctg gacacgggac acgccgccgc cgcgctggcg
     7621 ctggccgcgt ccccggccct cgacgtccgg gtctgcctcg acgcggacgc cgccctgctg
     7681 tccgccgccg ccggactgcc ccgtgccccg gactggcagg acgcctggcc cggcaccgag
     7741 ccggaactgc ccctggcggt agtccggttg gtgcgccggg gcggccggtc ggcggaccgc
     7801 ggaggggcgt tgagtgcctg ggcggccctg cctcacggtg cggcccctgc gccgctaccc
     7861 ggtgcggaca cggccccgcc ccgcgaactc gccgccgcac ggcacctgct ggaccacatc
     7921 gcccgtgccc ccgagccgac cggcggtacg tggcacccgg ccgcgcgccc gaagccggtg
     7981 accgacgacg tcctggaagc gcgccgaagc gccccgcccg gcgacctgaa ccacccgccc
     8041 ggaaacgacc tgctcgcccg gatcctggcc accgcgcgga cggcacaccc cgccggaccc
     8101 gcctggaccg cggcggccgg aggccccgcc ccggccctgt acgcgtcggt gcccggccgc
     8161 cacggtctcg gcgtccgcgc ctccggcgac gcgcgcccca ccctcgcgca ctgggccgcg
     8221 cgccagcagt gggtcggcac agcgggcgcg gtactgctcg cccacggctg ccccgaggac
     8281 gcgccaccgg ccgcggtgcg cagcagccac ctcatcgccg gatacgcggt cggcgcggcc
     8341 caggcccacg ccaccgcact gggcctgcgc tcacgcccca tcggctcctg gcagcaggcc
     8401 gacctgggcg cggcgctcgg cgacaccccc ggacgcgact ggatcgtgca cggtctggcc
     8461 ctgggtggtg gcggctcggc acctccgagt acaccgcagc ccgcctcacc tccgtagtcc
     8521 gcagctctgg tcacacggcc gaaaaccaac ctccgacccg tcacccgacg gccccgccag
     8581 gcgaggaaga acgcccatga tgctccaccc cgaactcctg cgcgccgcga acaccgcgcg
     8641 ccgcccgctc ggcctcgcca ccgcactgct cgcggcggtc accgccaccc acctcgccca
     8701 ggccgtcctg ctcgccctcg tgctctcccg gatcgcgcaa ggacagaccg cagccctggc
     8761 cccgctgctc acggccgtca tcgccatcgt cctggtccgc gccggcctcg gccgcgccca
     8821 gcgcctggcc gccgtcacgg cgggagccac cgtacgggtc gggctccgcg acaccctgct
     8881 gcgacggctc ggggcgctcg gccccaccgc gatcaccggg gcgcgggccg gagccgtgcg
     8941 cgccacgctg gtggacgggg tcgagggcgt cgacgcgtac atctcgcgct atctgcccca
     9001 atccctcatc acctgcgccg ttccgccgct gctgctcgtc gccgtcgcgc tcgtcgagcc
     9061 gtacgccgcc ctcgccctcg gccccgccct gctgctggcc ctcttcgggc cgcgctggtg
     9121 ggaccggctg ctcgcccggc gcggcaagga gcactgggac tcgtacgaag ccctcgccgc
     9181 cgactacctg gaggccctcc aggggatgcc gaccctgcgc accgccggcg ccgtgggccg
     9241 ggtacgggaa cggctggagc ggcggtcggc cgccctgcac cggaccaccg tcgccaaact
     9301 ccgggtctcg ctggtcgaca ccggcctcac cgacctcgcc gtccagggcg gcacggtcgc
     9361 cgcggtcctc gtggcgtgct cctcggccgc caccggccgt accgccgcca ccggtaccta
     9421 cctcctgctc ctcctcgcct ccgaatgctt ccgccccgtg cgcgacctct cccgcgaatg
     9481 gcacgcgggc tacctcgggg tgtcggcggc cgacggcatc gccgccctgc gcaccgccga
     9541 agcggccgtg ccggaccggg gcaccagggc cgccgtctgg aagaacgcac ccgaaatccg
     9601 gttcgaggac gtgcacttca cccacccggg cagcacccgc cccgccctcg acggtgtcag
     9661 cttcaccgcc gcccccgggc gcaccacggc cgtcgtcggg ccctccgggg ccggcaagtc
     9721 gaccctggtg agcctgctgc tgcggcaacg ggacccggac cggggccgcc tcaccgtcgc
     9781 cgggacggac accgccgcgt acaccctcgc ctcgctgcgc cggggcatcg ccgtcgtctc
     9841 gcaggagacc tacctcttcc atgccacgat cgcggagaac ctgcgcatcg cccgcccggc
     9901 cgccacggac gaacaactgc gcgccgccgc ccgtaccgcc gggatcgacc aggagatcgc
     9961 ccggctgccg gacggttacg ccaccctcgt cggcgaacgc ggcgccacgc tctccggtgg
    10021 acagcgccaa cggctcgccc tcgcgcgggc gttgctggcc gacgcgcccg tcctgatcct
    10081 ggacgaggcc accagcgcgg tcgacgaacg cggccaggcg cgcatcgtcc gggaactgac
    10141 ggcggccggc cgcggccgca cctgcgtcgt cgtcgcccac cggctcgacg ccgtacgcca
    10201 cgccgaccac atcgtcgtcc tcgacgcggg ccgtgtcgcg gcggcgggcg accacaccac
    10261 cctgctcgcg ggcggcggcg tctacgcatc gctcgtcgcc gccgggcgca ccgcacagga
    10321 agagcgcgcc gcatgaaccc gacaccggat ccgacacgga ctccgacacc ggccccagcc
    10381 ccggcgtcaa acccgactcc gacaccgaca ccgacaccga caccgacacc gacaccgaca
    10441 ccgacactgg ccccggcgtc aaacccgatt ccgaccccga ccccgacccc agccccggac
    10501 tccacctcga ctccgcccca ggcccccgcc ccgccccagg cccccacccc cgaaaccggc
    10561 gccctccgct cgctcctccc cgccctcggt gcgcaccgcg ccaccgtgct gcgcacctgc
    10621 ctggccgccc tcgtcgacca ggcggccctg gtcgccctcg tcacgctcgc cgcgtacacc
    10681 gtgggcaccg ccgtcaccga gcaccggccg cccgcccccg ggaccatcgc cctcctggcc
    10741 gggctcgtcc tgctccgggc cctcgccacc tggcgcgaga tggacctctc gcacgacctc
    10801 gcctaccggg tcctcgccga actgcgcgtc cgggtcttcg acgggctggc ccgcagcgcg
    10861 cccgcccgga tcgccggccg gcgcagcggc gacctcgcgg ccaccgcgct cggggacgtc
    10921 gaggcgctgg agttcttcta cgcccatgcc atcgcccaac tgctcgcgtc cggcgtggtc
    10981 ttcgcggtgt cggccgccgt gctggcggcc ctcgggccct ggctgctgct cgccgtcgtg
    11041 cccgccgcgc tgctcctgat ctggtcgccg ctcttcgaag cgcgcgggcg ggccgaacgc
    11101 ggggcccgga cccggagcgc gctcgccgag gtctcgtccg agaccgtgga gagcgtcgac
    11161 gggctgcgcg agctcctgat ggcaggggcc ctgaaccgca ggcgggcccg gctccggtcc
    11221 gccgggcgtc ggctcgcccg cgcccagcgc gccgaacagt cctgggagac cggcgcgggc
    11281 gcggcccgcg atctgctggt cgtcgccgcc gtcatcgcgg tcgtggcggc cgccgcccac
    11341 gccgcgtccg ccggacgcct ggacgggg
//
