LOCUS       NZ_CP079114            21406 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. WY228 chromosome.
ACCESSION   NZ_CP079114
VERSION     NZ_CP079114.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WY228
  ORGANISM  Streptomyces sp. WY228
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Volatile organic compounds produced by endophyte Streptomyces sp.
            WY228 mediate plant growth and salt stress tolerance by activating
            hormonal signaling and anthocyanin biosynthesis,
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JUL-2021) Key lab of biotechnology of medicinal
            plants, Jiangsu Normal University, No. 101 Shanghai Road, Xuzhou
            221116, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019287315.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 06:02:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,303
            CDSs (total)                      :: 7,213
            Genes (coding)                    :: 7,059
            CDSs (with protein)               :: 7,059
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 154
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 83 of 155
            Pseudo Genes (incomplete)         :: 99 of 155
            Pseudo Genes (internal stop)      :: 10 of 155
            Pseudo Genes (multiple problems)  :: 36 of 155
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:35:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5833257
            Orig. end                         :: 5854663
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP079114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21406
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="triceptide"
                     /region_number="23"
                     /rules="((cds(PF04055 and (TIGR04085 or SPASM)) and
                     triceptide_precursor) or triceptide_rSAM)"
                     /tool="antismash"
     cand_cluster    1..21406
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /kind="single"
                     /product="triceptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21406
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11406](+)"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11406
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="((cds(PF04055 and (TIGR04085 or SPASM))
                     and triceptide_precursor) or triceptide_rSAM)"
                     /neighbourhood="10000"
                     /product="triceptide"
                     /protocluster_number="1"
     gene            complement(900..1757)
                     /locus_tag="KV381_RS25735"
                     /old_locus_tag="KV381_25735"
     CDS             complement(900..1757)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102713.1"
                     /locus_tag="KV381_RS25735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25735"
                     /product="DUF4097 family beta strand repeat-containing
                     protein"
                     /protein_id="WP_030626143.1"
                     /transl_table=11
                     /translation="MPVSTWTIAEPRKLAFDDPVAALHVRIVDGTVNVVGSDEPDARLE
                     ISAVEGPPLIVTQEDGRLTVAYEDLPWQDLLRWFDPKGRRRSAVVTLVVPAASSVEVGV
                     IGAGAVVSGISGRTEVRGITGDSTLVGLTGAVRGESVSGSLEAQRVTGDLRFHSVSGDL
                     TVVDGAGTSVRAESVTGDMVLDVDPSGKPTDIRLTTVSGEIAIRLPHPADARVEANTAS
                     GTVSTAFEDLRVGGQWGAKKITGTLGAGTGTLRATTVSGSIALLRRPPAEDDARTAEPT
                     GKVL"
     gene            1911..2735
                     /locus_tag="KV381_RS25740"
                     /old_locus_tag="KV381_25740"
     CDS             1911..2735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061467.1"
                     /locus_tag="KV381_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25740"
                     /product="hypothetical protein"
                     /protein_id="WP_030626145.1"
                     /transl_table=11
                     /translation="MNATSTGALLLCRADPETVRPLAHLLREQMLLARAGEEWSVLVPE
                     GKPWRNGGPEQDAEPVDRVLGGWATALAVGSTWPVLALWWDADRAGYTLAAGFRRPVGY
                     IWLTDGTPVGEDEAMRTFAVRLGLDPVLDVQALEGLTRPDPEAGAEARLRGLLAVLTGT
                     GLALPAGLSPGESADRLRSVAAVQRGVERVEWAGWRDAVRVELDAVESSRIGPWVRGPR
                     ARAVAAVQLAAGLPLLLWGARRRSGGWAAAGAVLLAQGALGLAYERARAGTS"
     misc_feature    complement(1912..1926)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(2777..2962)
                     /locus_tag="KV381_RS25745"
                     /old_locus_tag="KV381_25745"
     CDS             complement(2777..2962)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061466.1"
                     /locus_tag="KV381_RS25745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25745"
                     /product="DUF6104 family protein"
                     /protein_id="WP_010061466.1"
                     /transl_table=11
                     /translation="MYFTDRGIEELEKRRGEEEVTFEWLAEQLRTFVDLNPDFEVPVER
                     LATWLARLDDEDDEDE"
     gene            3141..3497
                     /locus_tag="KV381_RS25750"
                     /old_locus_tag="KV381_25750"
     CDS             3141..3497
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447801.1"
                     /locus_tag="KV381_RS25750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25750"
                     /product="CU044_2847 family protein"
                     /protein_id="WP_086777095.1"
                     /transl_table=11
                     /translation="MSGRVQRIDLGDGNIVHARVSAATGYGSSDRDVGVADGAVARLEQ
                     LDELISRVGGTVLRAAAAVKPHEASVTFGVELTAKPGKAIAILADGEAKASVQVTLVWQ
                     LGEQAPEGPAGTDA"
     misc_feature    3570..3586
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.71"
                     /tool="antismash"
     gene            3577..5454
                     /locus_tag="KV381_RS25755"
                     /old_locus_tag="KV381_25755"
     CDS             3577..5454
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039783.4"
                     /locus_tag="KV381_RS25755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25755"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_158101221.1"
                     /transl_table=11
                     /translation="MWGSGFFVAPGWIVTAAHVLLPYLREDTDRPFWAAGDEQRYGVAP
                     TRVRLRQWLVSDVWSDSVPAQRDLALVQLLDGHIDHECVWLGDSAASTGGDRVSFGFRP
                     TSDEDDRVYGLWRGEVRANVDDGAVAVRFGPQAEFPPGVSGGPVLDPATGAVREIVKSG
                     RVGQDGGRAVSAAALRGFGPLYREVMDAHDRWHHARREDTGSWIAHQARLEAAESAGAE
                     RWSSDDRVQALNHLAALAPPPEGVVADLASHVRDQRLPRIDPGPVTWRDGHGLLYDEDG
                     RPLPAYVFMHYLRLAALLARGYGADTGRLDSWLARRLHQLPPQLRRLVEQAQLPDTRSA
                     ERIVIPYPGPDDPGHIVVVELDELPYGTLHWQIRIDDGSADDEIFAAEEDPNGVVPARL
                     RTHLRDPLVQAFRIADQASGGAPAPCEVVLPASYFDTPVHRWQLADEAPLGDPAHLPVG
                     VRRRIVLRNVDRRGEPDRHRLERWSAAVGSGPFSAGRIPPAGGLLRERHISGLPPSGIP
                     VLCHRAGLGTGNRAMESLLAAGHGIALWRIDGHDSGPCGADCEDLHKGVAEMLAGTGSA
                     PELPDRLRRIREEIHEGRTAGHWAEAVAVLYDDPRRPIPERPAWPVDSP"
     gene            5582..6601
                     /locus_tag="KV381_RS25760"
                     /old_locus_tag="KV381_25760"
     CDS             5582..6601
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447797.1"
                     /locus_tag="KV381_RS25760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25760"
                     /product="MoxR family ATPase"
                     /protein_id="WP_086777093.1"
                     /transl_table=11
                     /translation="MSDWLIYRGEGDPAPDRIGALPPPPPWRTFAGEPTGLPVPEPDSS
                     TTRRLGGRPLLPVQDEEAIQLINAALYLRRPLLVTGEPGSGKSTLAHAVAQELGLGRVL
                     QWSVVSRTELKQGLYEYDAIARLQDAQLSRERGGPDAPGAQGIGEYIKLGPLGTALLPA
                     ERPRVLLIDELDKSDIDLPNDLLNVLEEGEFRIPELERAAKREGGAATEVLDDDGRTVP
                     VSGGRVRCRAFPFVVMTSNGERDFPRPLLRRCIRLHLEPPRNERLAALVHAHFGEGAHE
                     VNRDLLERFGRGDDGLRPTDELLNAIFLTQHTDAKGGNRREEIARLLMRPLEQHPPQR"
     gene            6699..10004
                     /locus_tag="KV381_RS25765"
                     /old_locus_tag="KV381_25765"
     CDS             6699..10004
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041121.1"
                     /locus_tag="KV381_RS25765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25765"
                     /product="SAV_2336 N-terminal domain-related protein"
                     /protein_id="WP_266490025.1"
                     /transl_table=11
                     /translation="MREAGLDATAEDVADALWLAQWTDPFPRRPEAWTKQERSVPEGPT
                     VPESEGRPSPAPRVPSNASDTPPAERAALHVPAGDRRRRGDAGRGLAAAHVRVPTASTL
                     PDPLALQRALRPLQGFHSPSPSGRGTLDENATVHRAAETGVLQPVLRPAHRREARAQLL
                     MDVSSSTAVWEQTLDELRETFLRCGAFREVRVHYLHEDQDGAPGISTDFRPPTSPLPSP
                     AQLTDPTGRQLTLLLSDCAGPMWRSGAMHRLLHCWAAAMPVAVVQPLPQRMWRSTHLPA
                     RPGLLLRPERQAGRLEFVSAGDRPPRTVPVPVLALHHVSMGAWARMLSGAGQLTQRAAA
                     AWVGPGMVPAAKPAGSAAVPASERVRVFRRHASPTAVRLAQWLTTTPLELPVMQHLQRA
                     MLPESGPDALAEVLLGGLLTRVEREPGDGLAYAFREGVWDELHRRLAPGDAGRALNHLS
                     RYVEGRWGRTARNFPAMAVAYLSGTVDPPGPPDGLDDPLQREFAIVSAQVLRGSLPQTR
                     TSEAQTPGELAADARRRLGRFRRQRTARDLDLGISLLAKATEAERRRPDRYRLFADLAV
                     AFVERWEARRLGEDLGGALAAAERAIPGVPQAYGTLATVLRTLSEELAVGGAGTDAVPE
                     RYWQRAAEAGAPGDVEAVRFLLLDEAQRVLDRAASEDGASGRSAAIARIRVLQQLGRDF
                     GDQALRLYHPPPEAPDQWYRTMAFQSLEVLDALIASSPSPALVHLRGRSRVLLARHFAD
                     RVDRPTTGDHERVRALAGPAALDLAQSLARMDHATTTDGGRTGLDWEWAWAPEPTDLVE
                     GWKALAEAHELAWFGRGVATGQEQALADLAEALALAEALPPGGHRDATLLRCLEARALV
                     EMRRSRVPGIDRRSALDRIVGAWAEVLERTPEFDPSRAGSLHSHGVALMLRGQLDGSED
                     GLFDAVRVLRRSVAETSEKSPELAVRRLDLGRALLYRYRVAGAVVDLYEADWIIGAAGR
                     GTDHAETRALAYGARGEVAEELGLATTAEIRFAEAAAHYLQAADSWLAAGSVSVAAAHL
                     ESRARMLERIAGPDRARVEYDRALTVLTDHGEENSPVASRLRESVRRLGAGDE"
     misc_feature    7182..7184
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..10177
                     /locus_tag="KV381_RS25770"
                     /old_locus_tag="KV381_25770"
     CDS             10001..10177
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_precursor"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF041709.1"
                     /locus_tag="KV381_RS25770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25770"
                     /product="YxD-tail cyclophane-containing RiPP peptide"
                     /protein_id="WP_158101220.1"
                     /sec_met_domain="triceptide_precursor (E-value: 1.0,
                     bitscore: 10.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATCEDSSNPLPSFGQLVALAEGGGTTGHPVLDAVLTGLRQRTA
                     DAGNPVAYYEDAP"
     gene            10174..11406
                     /locus_tag="KV381_RS25775"
                     /old_locus_tag="KV381_25775"
     CDS             10174..11406
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     triceptide: triceptide_rSAM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SAM_SPASM_FxsB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007447794.1"
                     /locus_tag="KV381_RS25775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25775"
                     /product="FxsB family cyclophane-forming radical SAM/SPASM
                     peptide maturase"
                     /protein_id="WP_086777091.1"
                     /sec_met_domain="PTHR43273 (E-value: 5.9e-81, bitscore:
                     271.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="SAM_SPASM_FxsB (E-value: 4.2e-126,
                     bitscore: 419.5, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.1e-12, bitscore: 45.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="triceptide_rSAM (E-value: 1.0, bitscore:
                     1.0, seeds: 0, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARTLPLWPHRTLSSAGLTPVPLRQFVIKVHSRCNLACSYCYVY
                     RSPDQSWRERPPRVAHETMIRTAERIGEHARTHGLNRIRVELHGGEPLLAGPEPLLDQV
                     RAIRLAVPADCEVAPTVQTNGTLLTGPVLDRLATEGVRVGLSLDGGSALLNRRRVSHGG
                     RSSWPAVARAAALLARRGTQYAGILSTIDLDSGPSEVYSSLLELGPSGLDFLLPHANWG
                     APPAGRAAGPPGRHRPSPAPYGQWLAEVFDLWWQSDGVQVEVRLFTEILALLLGWESAA
                     EAVGLSPMVAVVVDTDGAIEQVDSLKSAYAGAPETGLDVFSNSFDEALHHPGIAARQLG
                     EEGLAPECRVCPVLRVCGGGNYAHRYAPASGFLHPSVYCADLEHLIRHIARRLDGTPVR
                     TGTPRGGGTAV"
     gene            11516..14494
                     /gene="fxsT"
                     /locus_tag="KV381_RS25780"
                     /old_locus_tag="KV381_25780"
     CDS             11516..14494
                     /codon_start=1
                     /gene="fxsT"
                     /inference="COORDINATES: protein motif:HMM:NF040586.1"
                     /locus_tag="KV381_RS25780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25780"
                     /product="FxSxx-COOH system tetratricopeptide repeat
                     protein"
                     /protein_id="WP_218786451.1"
                     /transl_table=11
                     /translation="MTDGSDRITVLFAGQSESWAKWVEEECGTAGIVTRLVRWDPLRRP
                     PPSEALTELLAEERVLLVLDDWYLRFDAGRYRAWAAVLGELLPTHRSRIRAVTVTPHRL
                     PEAARSLDPVSLHGVRREEAKQRLLTVCGLDLDERAGVDLDRGLRFPDEPPPVSNVERR
                     NRRFAGRDRVLERLHRLLQGGGGTTASDRSALVALQGSGGIGKTEVAREYTHRYAGDYD
                     LVWWVRSHTPLMAREDFAELAAALHVADGDELRGLIAAAQQRLAGLRQRWLLVFDGAEK
                     PQDLAELIPHGSGHVLITTRDASWSAHGADVVALPRFDRAESIDFVCRRAPRLSEEDAD
                     QLAEVVEDLPLLLDQTAAWLEAYPLIDVRRYVADIREGDPHALGVVPSGGDPQRFQAVW
                     STTLNSLDEEAPHVHELLKLMAHFSADMVPVGLLRAARASDLPAHLARLVGEPSAWNSA
                     LRRLSETTAMSLEYETGPQNDILTVGFLRMHGLFHRFVRSTLSPRDRERASETACRVLV
                     AADPRDPTAPRHWRRYADLIPHLEPSGALESADEDVRSFVLNCVEYLRMRGEYADGWDI
                     TRKALDRWRTVSKPTDRTVLVATHQYANMLRRLGRYAEAEDVGRDILERLYLVPEAQGI
                     ELLRAMNGLGGTLMALGKYDEAHRLYESATAMAIERLGDSTVPRTLALRSNLAQAIALC
                     GHYEDSLGRHQSIMEARVRLLGPRNALTLLSALHTAWTLRLLGRYPEAFALQERNTSLH
                     SQVLDREHSQTLLAQHNLALCARREGNLPFAKSLMKRVRERVTHRRGSHHPETLLISTD
                     YAMLLRDMGLVDEAWSIAESTARTYAARLGEKHPYAIGARDNCGVILRTLGEHEAARVI
                     GEETRTAMAAVLGADHPWSIGCAVNASSARAATGDPEGAIELGREALERAEDAVGGDHI
                     LTAGLKAGLALDLRTTGLAREAGLLTDEVAQMFARTSGKEHGQARFLASGERPYWDFEP
                     QPI"
     gene            complement(14581..18387)
                     /locus_tag="KV381_RS25785"
                     /old_locus_tag="KV381_25785"
     CDS             complement(14581..18387)
                     /EC_number="4.1.1.71"
                     /GO_function="GO:0004591 - oxoglutarate dehydrogenase
                     (succinyl-transferring) activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127532.1"
                     /locus_tag="KV381_RS25785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25785"
                     /product="multifunctional oxoglutarate
                     decarboxylase/oxoglutarate dehydrogenase thiamine
                     pyrophosphate-binding subunit/dihydrolipoyllysine-residue
                     succinyltransferase subunit"
                     /protein_id="WP_030079435.1"
                     /transl_table=11
                     /translation="MSSQSPSNSSISTDQASPGTNPAAAFGANEWLVDEIYQQYLQDPS
                     SVDRAWWDFFADYKPGATGTADKPAPGAGASGAPAAEAAPAPAAAPAPVKAAPAAAPAA
                     PAQPAPAKAAPAAPAPAKPAAAKPAAAPAKPKAKADESTEAPAGPEYVTLRGPSAAVAK
                     NMNASLELPTATSVRAVPVKLLFDNRIVINNHLKRARGGKISFTHLIGYAMVQALKAMP
                     SMNYSFAERDGKPTLVKPEHINLGLAIDLVKPNGDRQLVVAAIKKAETLNFFEFWQAYE
                     DIVRRARIGKLGMDDFTGVTASLTNPGGIGTVHSVPRLMPGQGLIMGVGAMDYPAEFQG
                     TSQDTLNKLGISKVMTLTSTYDHRVIQGAASGEFLRVLSQLLLGENEFYDEIFKALRIP
                     YEPVRWLKDIDASHDDDVTKAARVFELIHSYRVRGHVMADTDPLEYHQRKHPDLDITEH
                     GLTLWDLERDFAVGGFAGKTMMKLRDILGVLRESYCRTTGIEFMHIQDPKQRKWLQDRV
                     ERPRPKPEREEQLRILRRLNAAEAFETFLQTKYVGQKRFSLEGGESVIPLLDAVIDSAA
                     EARLDEVVIGMAHRGRLNVLANIVGKSYAQIFREFEGNLDPRSMHGSGDVKYHLGAEGT
                     FTGLDGEQIKVSLAANPSHLEAVDPVLEGIARAKQDIINKGGTDFTVLPVALHGDAAFA
                     GQGVVAETLNMSQLRGYRTGGTVHVVINNQVGFTAAPESSRSSMYATDVARMIEAPIIH
                     VNGDDPEAVVRVARLAFEFRQAFNKDVVIDLICYRRRGHNEGDNPEFTNPQMYTLIDKK
                     RSVRKLYTESLIGRGDITLEEAEQALQDFQGQLEKVFAEVREATSQPASPHVPEPQAAF
                     PVAVETAVSAEVVKRIAESQVNIPESITVHPRLMPQMQRRAASVENGTIDWGMGETLAI
                     GSLLMEGTPVRLAGQDTRRGTFGQRHAVLVDQVTGEDYTPLLYLADDQARYNVYDSLLS
                     EYAAMGFEYGYSLARPESLVIWEAQFGDFVNGAQTVVDEFISSAEQKWGQTSGVTLLLP
                     HGYEGQGPDHSSARPERFLQMCAQDNMTVAMPTLPSNYFHLLRWQVHNPHHKPLIVFTP
                     KSMLRLKAAASSIEEFTTGGFRPVIGDASVKAEDVRKVVFVSGKLYYDLDAEREKRGDT
                     ETAIIRLERLYPLPGAEIQAEIAKYPNAEKYLWAQEEPANQGAWPFIALNLIDHLDLAV
                     GSDVPHGERLRRISRPHGSSPAVGSAKRHQAEQTQLVNEVFEA"
     gene            complement(18670..19746)
                     /locus_tag="KV381_RS25790"
                     /old_locus_tag="KV381_25790"
     CDS             complement(18670..19746)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018959058.1"
                     /locus_tag="KV381_RS25790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25790"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_030626151.1"
                     /transl_table=11
                     /translation="MTWPGPGMRPFSIKAKLGTLVVVSVFITTGLLIVALRTRTEFQFI
                     TVFSVIATLLITQFVAHGLTAPLDEMRAVARSISHGDYTRRVSGAGRRDELGDLAQTIN
                     RMADDLEAEDRHRKELVANVSHELRTPIAALRAVLENVVDGVSAADPETMRTALKQTER
                     LGRLVETLLDLSRLDNGVVALKSRRFEVWPYLSGVLKEANLAASQRRLSSGSGNHSRTD
                     VHLHLDVSPPELTAHADAERLHQVVANLIDNAVKHSPPHGRVTVLARRGVYPESLELEV
                     MDEGPGIPEAERHRVFERFNRGQAPSPHGPGSDGGTGLGLAIARWAVDLHGGRIGVAES
                     ARGCRIQVTLPGIPEQRG"
     gene            complement(19743..20480)
                     /locus_tag="KV381_RS25795"
                     /old_locus_tag="KV381_25795"
     CDS             complement(19743..20480)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845486.1"
                     /locus_tag="KV381_RS25795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_25795"
                     /product="response regulator transcription factor"
                     /protein_id="WP_030079431.1"
                     /transl_table=11
                     /translation="MEQTHTTHNGVAATPGAQRRVLVVEDDATIVDAISARLRAEGFLV
                     QTALDGPAAVDAAEAWQPDLMVLDIMLPGFDGLEVCRRVQAQRPVPVLMLTARDDETDM
                     LVGLGVGADDYMTKPFSMRELAARVHVLLRRVERAALAAVTPRSGILRLGELEIDHAQR
                     RVRVRAEDVHLTPTEFDLLVCLANTPRAVLSREQLLAEVWDWADASGTRTVDSHIKALR
                     RKIGAERIRTVHGVGYALETPAP"
     misc_feature    20976..20989
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.59"
                     /tool="antismash"
ORIGIN
        1 gcaggcggtc cagatcgcgc accgggtcgc cggtcgtcgg cgcgtcctgc ccccagtccg
       61 caccgggagc cgggtcctgg acgggcgggg cggtctccgg ctcgggcttg ccgaacggcg
      121 gccaggcgcc ggaccgggcg aagccgccga gctggccggt gatctccgcg aggccttccc
      181 gtacgccgga gggccagtcg ccccgcgcga agtgctcctg gacctggcgg gcggcggtct
      241 gcatctgctc gcgcgccttc tcctgggcct ccttggcctg acggcgggcc tgctgggcgt
      301 cctcgcgggc gcgccgggac tcgtccttcg cccggcgcgc ctgctccttc cactcctgct
      361 tggcccggcg cagctcctcc ttcgccgtac gccacgcctc gctgtcgccg aggtcgccca
      421 gattgccgaa gtcgccgaag tcgccgaagg gggaggacgg gatgcccttg ctccggccct
      481 tgcggtcctc ggcccccgta cccgtaccgt gccgggactc cgaggcggcg gcccgcatgt
      541 cgctgcggag ccggcccgcg gcgcctcgta cgtcgtcgcg tatctcggcg gccagctcgg
      601 agaccgagtc gcggatctcc agctccagat cggccagttc accgctgcgg cccgccagct
      661 cctcgcggcc ggcgtcggtg atcgagtaga ccttgcggcc gccctcggtg gcatgggtga
      721 ccaggccctc ggcctccagc ttggccagcc gggggtagac cgtgccggcg gacggggcgt
      781 acagaccctg gaagcgctcc tccagcagcc ggatgacctc gtaaccgtgg cgcggagcct
      841 cgtccaggag cttgaggaga tacagccgca gacggccgtg ggcgaaaacg ggagccatgt
      901 cagagaacct ttccggtcgg ctcggcggtg cgggcgtcgt cctcggcggg cggcctgcgc
      961 aacagggcga tcgaaccgga gacggtcgtc gcccgcaggg tcccggtccc ggcgcccagc
     1021 gtgccggtga tcttcttcgc gccccactgc ccgccgaccc gcaggtcctc gaaggcggtg
     1081 gagacggtcc cgctcgcggt gttcgcctcg accctggcgt cggccgggtg cggcagccgg
     1141 atcgcgatct cgccggacac cgtggtcagc cggatgtccg tcggcttccc ggaggggtcg
     1201 acgtccagca ccatgtcgcc ggtgaccgac tcggcccgga ccgaggtccc cgccccgtcg
     1261 accaccgtca gatcgccgga caccgagtgg aagcgcagat ccccggtgac gcgctgggcc
     1321 tccaggctgc ccgagaccga ctcgccgcgc accgcgccgg tcagcccgac gagcgtggag
     1381 tcgccggtga tgccgcggac ctcggtgcgg ccgctgatcc cggagacgac ggccccggcg
     1441 ccgatcacgc cgacctcgac cgaggaggcg gccggcacga cgagcgtgac gacggcgctg
     1501 cggcggcggc ccttggggtc gaaccagcgc agaaggtcct gccagggcag atcctcgtag
     1561 gccacggtca gccggccgtc ctcctgggtc acgatcagcg gcggcccctc gaccgcggag
     1621 atctccagcc gggcgtccgg ctcgtcgctc ccgaccacgt tgaccgtgcc gtcgacgatg
     1681 cgcacatgga gcgccgccac cggatcgtcg aaggcgagct tccgcggctc ggcgatggtc
     1741 catgtcgaca caggcatgga tgtgacctcc cggaacgcgt gacgacgcaa catatcgcgt
     1801 ctcgtacgga acacgatata tcgcggatcg gtgaagtcaa ggccgagcga gaggcggtcg
     1861 agcagtatca agaacgccaa accatgacaa attgccctag cgtgtgagcc atgaacgcga
     1921 catccaccgg ggccctcctg ctctgccggg ccgaccccga gaccgtacgg ccgctcgccc
     1981 acctgctgcg cgagcagatg ctgctggccc gcgcgggcga ggagtggagc gtgctcgtcc
     2041 cggaggggaa gccctggcgg aacgggggcc cggagcagga cgccgagccg gtggaccggg
     2101 tcctgggcgg ctgggccacc gccctcgcgg tcggctccac ctggccggtg ctcgccctgt
     2161 ggtgggacgc cgaccgggcc ggatacaccc tcgccgccgg gttccgccgg cccgtgggct
     2221 acatctggct gaccgacggc accccggtgg gcgaggacga ggccatgcgc accttcgcgg
     2281 tccgcctcgg cctcgacccg gtgctggacg tacaggcgct ggaaggactc acccgccccg
     2341 acccggaggc gggcgcggaa gccaggctgc gcggactgct cgccgtcctc accggcacgg
     2401 ggctcgccct gcccgccgga ctctcaccgg gcgagagcgc cgaccggctg cgcagcgtcg
     2461 cggcggtgca gcgcggggtg gagcgcgtcg agtgggccgg ctggcgcgat gccgtacgcg
     2521 tagagctgga cgcggtcgag agcagccgga tcggcccgtg ggtgcgcggc ccccgcgccc
     2581 gggccgtcgc cgccgtccag ctcgcggccg gcctcccgct cctgctgtgg ggcgcccgcc
     2641 gtcgcagcgg cggctgggcg gcggccggcg cggtgctcct ggcccagggc gcgctgggac
     2701 tcgcgtacga acgggccagg gcgggcactt cctgagccgg gtggatcagg gtctgaggat
     2761 cagaccctga ggatgatcac tcgtcctcgt cgtcctcgtc gtccagccgg gccagccagg
     2821 tcgcgaggcg ctcgacgggc acctcgaagt cggggttgag atcgacgaac gtccgcagct
     2881 gctcggcgag ccactcgaag gtgacctcct cctcgccgcg ccgcttctcc agttcctcga
     2941 tgccacggtc cgtgaagtac aagacgtgct cctgatgcct gcggatgttc tcacctgaag
     3001 ggtaggacgt caccgctgcg gccggatatc gacggtgtcc gtggaagccc tctcgcccgg
     3061 cgggcttcgg acacgtaatc ttggcgaccg catcaagtca tctgcagggc cagcgccttg
     3121 acgcgcggat cgggggagcc gtgagtggtc gcgtacaaag aatcgatctc ggtgacggca
     3181 atattgtcca tgcgcgcgtg agcgccgcca caggttacgg ctcctccgac cgggacgtcg
     3241 gcgtcgccga cggcgcggtg gcccgcctgg agcagctcga cgaactgatc tcgcgtgtcg
     3301 gtggcacggt gctccgcgcc gccgcggccg tgaagccaca tgaggcgtcg gtgaccttcg
     3361 gggtggaact gactgccaag ccaggcaagg cgatcgcgat cctggcggat ggcgaggcca
     3421 aggcatcggt gcaggtcacc ctcgtctggc agttgggcga gcaggccccg gaggggccgg
     3481 ccggcacgga tgcctgaggg cctgaccagc cttgatgccc ttgtccgggc agctacggtc
     3541 cgcttccttc cggacgacga tccggacaat gcccaaatgt ggggcagcgg cttcttcgtc
     3601 gcaccgggct ggatcgtgac cgccgcgcac gtgctcctgc catacctgcg cgaggacacc
     3661 gaccggccct tctgggcggc tggcgacgaa cagcgctacg gcgtcgcgcc gacgcgtgtg
     3721 aggctgcggc agtggctcgt cagcgacgtg tggagcgact cggtcccggc ccagcgggac
     3781 ctggcgctgg tgcagctgct cgacggacac atcgaccacg agtgcgtctg gctgggcgac
     3841 agcgcagcct cgacgggcgg agaccgggtt tccttcgggt tccggccgac atcggacgag
     3901 gacgaccggg tgtacgggct ctggcgcggc gaggtccggg ccaacgtgga tgacggtgcc
     3961 gttgccgtcc ggttcggccc acaggccgag tttccgccag gagtctcagg cggccccgtc
     4021 ctcgatcccg ccaccggcgc cgtacgggag atcgtcaaat ccggccgtgt ggggcaggac
     4081 ggcggccggg ctgtgtcggc tgccgccctg cgcggattcg gccccctcta ccgcgaggtg
     4141 atggacgccc acgaccgctg gcaccacgcg cggcgtgagg acaccggcag ctggatcgcg
     4201 caccaagcgc gactggaggc cgccgagagc gccggggccg agcgatggtc cagcgatgac
     4261 agggttcagg ccctcaacca cctggccgcc ctcgctccgc caccggaagg cgtcgtggcc
     4321 gacctggcct cgcacgtacg cgaccagcgt ctgccccgca tcgacccggg ccccgtcacc
     4381 tggcgggacg gccacggact gctctacgac gaggacggca gaccgctgcc cgcctacgtc
     4441 ttcatgcact acctacggct cgctgccctg ctcgcccggg gctacggggc cgacaccggc
     4501 cggctcgaca gctggctcgc ccgccggctc caccagctcc ccccacagtt gcgccgtctc
     4561 gtcgaacagg ctcaactgcc cgacacgcgg agcgcggagc ggatcgtcat cccctaccct
     4621 ggccccgacg atcccggcca catcgtcgtc gtcgagcttg acgaactgcc ttacgggacc
     4681 ctgcactggc agatcagaat cgacgacggc agcgccgacg acgagatctt cgccgccgag
     4741 gaggacccca atggggtggt gcccgcccgg ctccggactc atctgcgtga ccccctcgtc
     4801 caggcgttcc gtatcgccga tcaagcgagc ggcggagcac cggcgccgtg cgaagtcgtg
     4861 ctccccgcct cgtacttcga cacgccggtg caccgctggc aactggcgga cgaggcaccc
     4921 ctcggtgacc cggcccacct gccggtgggc gtgcggcgac ggatcgttct ccggaacgtg
     4981 gaccggcgtg gggagcccga ccggcaccgc ttggaacggt ggtcggccgc agtgggctcc
     5041 ggcccgttct ccgcaggccg gatcccgccc gccggagggc tcctgaggga gcgccacatc
     5101 tcaggactcc cgccgtcggg catcccggtg ctctgccacc gagcgggcct ggggaccggc
     5161 aatcgggcga tggagtccct gctcgccgca gggcacggca tcgccctgtg gcgcatcgac
     5221 ggtcatgaca gcgggccgtg cggcgccgac tgcgaggatc tgcacaaggg tgtggccgaa
     5281 atgctggccg gaaccggatc ggctcccgaa cttcccgacc ggctgcgccg gatcagggag
     5341 gagatccacg aggggcgaac ggccgggcac tgggccgagg ccgtcgccgt cctgtacgac
     5401 gacccgcgcc gaccgatccc cgaacgtccg gcatggccgg tggattcgcc atgacgatgt
     5461 ggccggaaag cagctttggc ccggcaccgc gggggtacat ttcccggagt ccctcacggg
     5521 cgctccccgc ccccgtcggc cggagcgtgg aaaggcaccg atcgccgacg aggagtggaa
     5581 gatgagcgac tggctgattt accggggcga gggcgatccg gccccggacc ggatcggcgc
     5641 gcttccgccc ccaccccctt ggcggacctt cgcaggcgag ccgaccgggc ttccggtccc
     5701 cgagccggac tcctcgacca cacgccgcct cggcgggcgt ccgctcctgc ccgtccagga
     5761 cgaggaagcg atccaactca tcaacgccgc gctgtatctg cgccgaccgc tcctggtgac
     5821 cggtgaaccc ggctcaggca agagcaccct cgcccatgcc gtcgcccagg aactcggcct
     5881 cggacgggtc ctgcagtggt ccgtcgtcag ccgtacggag ctgaagcagg ggctgtacga
     5941 gtacgacgcg atcgcccgcc tccaggacgc ccagctctcc cgcgagcgtg gcggaccgga
     6001 tgcccccggc gcacaaggca tcggcgagta catcaaactc ggtccgctgg gcacggcact
     6061 tctgcccgcc gaacggcccc gggtcctgct catcgacgag ctggacaaga gcgacatcga
     6121 cctgcccaac gatctcctga acgtactgga ggagggcgag ttccggattc ccgagctgga
     6181 gcgtgcggcc aagcgcgagg gcggcgcggc cacggaggtc ctggacgatg acggccggac
     6241 ggtccccgtc agtggcggca gggtccgctg ccgtgctttt cccttcgtcg tgatgacgag
     6301 caacggtgag cgggactttc ctcggccact gctccgtcgc tgcattcgtc tgcacctgga
     6361 gccaccgcgc aacgaacggc tcgccgcgct ggtgcacgcc cacttcgggg agggagccca
     6421 cgaggtcaac cgcgatcttc tggagcgttt cggccggggc gacgatgggc tgcgtcccac
     6481 ggacgagctg ctcaacgcga tcttcctcac ccagcacacc gacgccaagg gaggcaaccg
     6541 gcgggaggaa atcgcccggc tgctgatgcg ccccttggag cagcatccgc cgcagcggtg
     6601 acatcgccat gacccccgca gcccctcaag gctcccggcc cgctcccgac gaggccctcg
     6661 gccggccacc cagcacactc acggccctgg tcgcgcgcat gcgggaggcc gggctcgacg
     6721 ccaccgccga agacgtcgcg gacgccttgt ggctggccca gtggacggac cccttcccgc
     6781 gccggccgga ggcatggacg aagcaggaac ggagcgtgcc cgagggcccc acggtcccgg
     6841 agagtgaagg gcgcccttca ccggcacctc gtgtgccgtc gaacgcctcc gacaccccgc
     6901 ccgcagagcg tgcggccctg cacgtccccg ccggtgacag aaggcgccgc ggcgacgcag
     6961 gccgaggcct ggccgcggcg catgtacggg ttcccaccgc atcgaccttg cccgacccgc
     7021 tcgccctgca gcgggccctg cgtcctttgc agggcttcca ctcaccgtcg ccgtccgggc
     7081 ggggcacgct cgacgagaat gccacggtgc accgggcggc ggagacgggg gtactgcagc
     7141 cggtgctgcg tcccgcacac cgccgtgagg cacgagccca gttactcatg gacgtctcgt
     7201 cctcgaccgc agtgtgggaa cagacgctcg acgaattgcg ggagaccttt ctgcggtgtg
     7261 gcgcgttccg tgaagtccgc gtccactacc ttcacgagga ccaggacggc gccccaggca
     7321 tctccaccga tttccgcccg cccaccagcc ctctgccgtc cccggctcag ctgaccgatc
     7381 ccactggccg ccagctcacg ctgctgctca gcgactgcgc cgggccgatg tggcgcagcg
     7441 gcgccatgca ccggctgctg cactgctggg ccgcagccat gccggtcgcg gtcgtccagc
     7501 cgctgcccca gcgcatgtgg cgcagcactc acctgcctgc tcggcccggc ctgctccttc
     7561 ggcccgaacg gcaggccgga cggctggagt tcgtctccgc aggggacagg ccaccgcgca
     7621 cggttccggt tcccgtactt gccctgcatc acgtgtcgat gggggcctgg gcgcggatgc
     7681 tgtccggcgc cggacagctg acgcagcgcg ccgccgcggc gtgggtcggt cccgggatgg
     7741 tccccgccgc caagcccgcg ggctcagccg ctgtcccggc ctcggagcgg gtccgggtct
     7801 ttcgccggca cgcttctcct accgcggtca ggcttgccca gtggctgacc acaaccccgc
     7861 tggaactgcc ggtcatgcag cacctccagc gcgccatgct ccccgagagc ggacccgatg
     7921 ccctcgcgga agtgctcctg ggcggcctgc tcacccgggt cgagcgggaa cccggagatg
     7981 gcctcgccta cgcgttccgc gagggagtct gggacgaact gcaccgcagg ctcgcccccg
     8041 gggatgccgg ccgggccctg aaccatctct cccgctacgt ggagggacgc tggggacgca
     8101 ccgcccgaaa ctttcccgct atggctgtgg cctacctctc cggtacggtc gacccgcccg
     8161 gcccgccgga tggcctggac gaccccttgc agcgggagtt cgccatcgta tccgctcagg
     8221 ttctgcgtgg ttcgctccca caaacccgga ccagcgaggc acagactccc ggtgagctgg
     8281 cggccgatgc ccggagaagg ctcggacgct tccggcggca gcgaaccgcc cgcgatctcg
     8341 acctcggcat ttccctgctg gccaaggcca cggaggcgga acggcggcgc cccgaccgct
     8401 atcggctctt cgccgacctc gccgtcgcct tcgtcgagcg gtgggaggcg cgccgtctcg
     8461 gcgaggatct cggcggcgcg ctggccgccg ccgagcgcgc gatccccggc gtgcctcagg
     8521 cgtacgggac tctcgccacc gttctgcgga ctctgtccga ggagttggcg gtggggggag
     8581 ccggtaccga tgccgtgccg gagcggtact ggcagcgggc cgccgaggcc ggcgcgcctg
     8641 gtgacgtgga ggccgtacgg ttcctgctgc tggacgaagc tcagcgagtt ctggaccgtg
     8701 cggcctccga ggacggtgct tccggacggt cggcggcgat cgctcgtatc cgggtgctcc
     8761 agcagctggg ccgggatttc ggcgatcagg cgctgcgcct ttaccacccg cccccggagg
     8821 cgccggacca gtggtaccgg acgatggctt tccagtcgct ggaggtgctc gacgctctga
     8881 tcgcgtcgag cccgtcacct gcgctggtcc atctgcgggg ccgctcacgg gttctgctcg
     8941 cccggcactt cgcggatcgg gtggaccgcc cgacgaccgg ggaccacgag cgtgtccggg
     9001 ccctcgccgg cccggccgcc ctcgacctgg ctcagtcgct cgcccgaatg gaccacgcca
     9061 ccaccaccga cggcggaagg acgggcctgg actgggagtg ggcctgggca cccgagccca
     9121 ccgacctcgt cgaggggtgg aaagccctgg cggaggccca cgagctggcc tggttcggga
     9181 ggggcgtggc caccgggcag gagcaagctc tggccgacct cgccgaagcc ctcgcgctcg
     9241 ccgaggcact gccgcccggc ggtcaccgtg acgcaactct gctgcgttgt ctggaggcga
     9301 gggcgctcgt cgaaatgcgg cgctcccggg tgccgggaat cgaccggcgg tcggccctcg
     9361 accggatcgt gggtgcctgg gccgaagtgc tggaacgcac acccgaattc gacccgagcc
     9421 gcgcgggaag tctgcacagc cacggggtgg cgctgatgct gcggggccag ctcgacggct
     9481 ccgaggacgg gttgttcgac gccgtccggg tactgcgccg gagcgtggcg gagacctcgg
     9541 agaagagccc cgaactagcc gtacggaggc tcgacctggg gcgtgccctg ctgtaccgct
     9601 accgggtcgc gggagcagtg gtcgacctct atgaggccga ttggatcatc ggggcggcgg
     9661 ggcggggcac ggaccacgcc gagacacggg ccctcgcgta cggggcccgg ggtgaggtgg
     9721 ccgaggagct cggactcgcc accacggccg agatacggtt cgccgaggcg gcggcccact
     9781 acctgcaggc cgctgacagc tggctcgctg ccgggtcggt gtccgtagcc gctgcgcacc
     9841 tggagagccg ggccaggatg ctggaacgga tcgccggccc ggaccgcgca cgtgtcgagt
     9901 acgaccgggc actgaccgtt ctgacggacc acggcgagga gaactccccg gtcgcgtccc
     9961 ggctgagaga gtccgtgcgc aggctcggag ctggtgacga atgacggcga cgtgcgagga
    10021 cagcagcaac cccctgccct ctttcgggca gttggtcgca ctggccgagg gcggtggcac
    10081 gaccggccac ccggtgctgg acgccgttct caccggactc cgtcaacgta ccgccgacgc
    10141 cggaaatccg gtcgcgtact acgaggacgc cccgtgacgg ctcgcaccct gccgctgtgg
    10201 ccccaccgga cgctgagcag cgccgggctg accccggtcc cgctgcggca gttcgtgatc
    10261 aaggtgcaca gccggtgcaa tctcgcctgc tcctactgtt acgtataccg cagccccgat
    10321 cagagctggc gcgagcgtcc gccccgggtt gcgcacgaga ccatgatccg caccgcggag
    10381 cggatcggcg agcatgcgcg tacccatggg ctgaaccgta tccgggtgga actgcacggt
    10441 ggtgaaccct tgttggcggg ccccgaaccg ctcctggacc aggtccgggc catccgcctg
    10501 gctgtccccg ccgactgcga ggtggcaccg accgtccaga ccaatggaac gttgctcacc
    10561 ggaccggtcc tggaccggct tgccaccgaa ggcgtccggg tcggcctcag cctcgatggc
    10621 gggagcgccc tgctcaatcg gaggcgagtg agtcatgggg gacggtcctc ctggccggcc
    10681 gttgcccgtg ccgccgcact gctggcccgg cgcggcaccc agtacgcggg cattctcagc
    10741 acgatcgatc tcgacagcgg tccgagcgag gtgtactcct cgctgctgga gctggggccg
    10801 tccgggctgg acttccttct gccgcatgcc aattgggggg cgcccccggc cggtcgggca
    10861 gccggcccgc ccggccgtca ccggccgagc ccggcaccct acgggcagtg gctggcggag
    10921 gtcttcgacc tctggtggca gtcggacggg gttcaggtgg aagtccggct gttcaccgag
    10981 atcctggccc tgctgctggg gtgggagagt gcggccgaag ctgtcggtct ctccccgatg
    11041 gtggccgtcg tggtcgacac cgacggcgcc atagaacagg tcgactcgct caagtccgcc
    11101 tacgcgggcg ccccggaaac cggtctcgac gtgttctcca actccttcga cgaggcgctg
    11161 caccacccgg gcatcgccgc ccggcagctc ggcgaggaag ggctcgcgcc cgagtgccga
    11221 gtctgcccgg tgctccgggt gtgcggaggc ggcaactacg cccaccgata tgcccccgcc
    11281 agcggcttcc tgcaccccag cgtctactgc gccgaccttg aacacctcat ccggcacata
    11341 gcgcgacggc tggacgggac accggtccgc acggggacac cgaggggcgg cggcaccgcg
    11401 gtgtgatgcg gcagacagag ccaattggtc gtcaactgcc gtgtctcgca caatatctga
    11461 cgcacaatgg gattgtttgg gcgcaggtgg acaggtgggc cgaggaggtt cccgtatgac
    11521 cgatggttcc gaccgcatca ccgtcctttt cgccggccag agcgaatcct gggccaagtg
    11581 ggtcgaggag gaatgcggga ccgcgggcat cgtcacgcgg ctcgtccgct gggatcctct
    11641 gcgccgtcct ccccccagtg aggcactcac cgaactgctt gccgaagaac gtgtactgct
    11701 cgtgctggac gactggtacc tccgcttcga cgcgggacgg taccgggcct gggccgccgt
    11761 gctcggcgag ctgctcccca cacaccggtc acggatccgt gcggtcaccg ttaccccgca
    11821 tcgcctcccc gaggccgccc gcagcctgga tccggtcagc ctgcacggtg ttcggcgaga
    11881 ggaagccaaa cagcgactgc tcaccgtctg cggactggac ctggacgaac gcgccggggt
    11941 cgacctcgat cgcgggctga ggttcccgga cgagcccccg ccggtgtcga acgtggagcg
    12001 gcgcaatcgg cgtttcgcag ggcgcgaccg ggtgctggaa cggctgcacc gacttcttca
    12061 gggaggaggc gggacaaccg catccgaccg ttcggccctg gttgccctgc agggttcagg
    12121 gggcatcggc aagacggagg tggcccgcga gtacacccac cggtacgcag gtgattacga
    12181 ccttgtctgg tgggtcagat cccacacccc gctcatggcc cgggaggact tcgcggagct
    12241 cgccgccgcg ctccacgtcg ccgacggcga cgaactgcgc ggtcttatcg ccgcagccca
    12301 gcaacgcctc gcaggcctcc ggcagcgctg gctcctcgtg ttcgacgggg cggagaagcc
    12361 gcaggacctg gcggaactca ttccccacgg ctcgggccac gtgttgatca ccacacgcga
    12421 cgcctcgtgg tccgcgcacg gggccgacgt ggtggctctg ccccgtttcg accgggccga
    12481 gagtatcgac ttcgtctgcc gcagggcccc caggctcagc gaggaggatg ccgatcagct
    12541 cgccgaggtg gtcgaggacc tgccgctgct tctcgaccag acagccgcct ggctggaggc
    12601 gtatccgctc atcgacgtca ggcgctatgt cgcggacatc cgcgaggggg acccacatgc
    12661 cctcggagtc gtgccctcgg gcggcgaccc gcagcggttc caggccgtgt ggtccaccac
    12721 actcaactcc ctcgacgagg aggcgcctca cgtccatgaa ctcctcaaac tgatggccca
    12781 cttctccgcc gacatggttc cggtcggcct gctccgggcg gcgcgcgcct ccgacctgcc
    12841 tgctcacctg gcccgcctgg tcggcgagcc gagcgcctgg aattccgcgc tgcgcaggct
    12901 ctcggagacg accgccatgt ccctggagta cgagaccgga ccgcagaacg acatcctcac
    12961 cgtcggcttc ttgcggatgc atggactctt ccaccgcttc gtccgcagca cactgtcgcc
    13021 ccgcgaccgc gaacgggcct ccgagaccgc ctgcagggtt ctggtcgcgg ccgatccccg
    13081 ggacccgaca gcgccccgcc actggcgacg ctacgcggac ctgattcccc acctggagcc
    13141 ctcgggcgcc ctggagtcgg cggacgagga cgtgcgcagc ttcgttctca actgtgtcga
    13201 gtatctccgt atgcggggcg agtacgccga cggctgggat atcacccgca aggctctcga
    13261 ccgctggcgt acggtgtcga agcccaccga ccggaccgtc ctggtcgcga cccaccagta
    13321 cgccaacatg ctgcggcgcc tgggaaggta cgccgaggcc gaggacgtcg gccgggacat
    13381 cctggagcgg ctgtacctcg taccggaggc ccagggcatc gagctgctgc gcgccatgaa
    13441 cgggctcggc ggcacgctga tggctctcgg aaagtacgac gaggcgcacc gcctctacga
    13501 gtcggcgacc gccatggcca tcgagcgtct gggcgacagc acggtgccgc gcactcttgc
    13561 cctgcgcagc aacctggccc aggccatcgc tctgtgcggc cactacgagg actcgctcgg
    13621 tcggcaccag tcgatcatgg aagcacgcgt ccggctgctc ggcccccgta acgccctgac
    13681 gttgctttcg gcgctgcaca ccgcgtggac gctccgcctg ctgggccgct atccggaagc
    13741 cttcgcgctc caggaacgca acacctccct gcacagccaa gtgctcgatc gggagcactc
    13801 ccagaccctg ttggcccagc acaatctggc gctgtgcgct cgccgggagg gcaatcttcc
    13861 gttcgccaag tccctgatga agcgggtccg ggagagagtg acgcaccgcc ggggcagcca
    13921 ccacccggag acactgctca tttccaccga ctacgccatg ctcctgcggg acatgggtct
    13981 cgtcgacgag gcgtggagca tcgccgagtc cacagcccgc acgtacgccg cgcggcttgg
    14041 agagaagcac ccgtacgcca tcggagcccg ggacaactgc ggcgtcatcc tgcggaccct
    14101 cggcgagcac gaggccgcac gggtaatcgg tgaggagaca cggacggcga tggcggccgt
    14161 cttgggcgcg gaccatccct ggagcatcgg ctgcgctgtc aacgcgtcct cggcccgtgc
    14221 tgccacgggc gatcccgagg gtgcgatcga gctgggacgc gaggctctgg aacgggccga
    14281 agacgccgtt ggcggtgatc acatcctgac ggcaggtctc aaggcggggc tcgccctgga
    14341 cctgcggacg acgggccttg cgcgggaggc cgggctgctc accgacgaag tggcgcagat
    14401 gttcgcccgg acgtccggga aggaacacgg ccaagcccgg ttcctggcgt cgggcgagcg
    14461 gccctactgg gacttcgagc ctcagccgat ctgacccggc cgatcagaaa acgccccggc
    14521 cctcccccgc aaggttcgcg gtgggagggc cggggcgttc gcacggtccc gtgtgaatga
    14581 tcaggcctcg aagacctcgt tgaccagctg cgtctgctcc gcctggtggc gcttggccga
    14641 gccgaccgcc ggggacgagc cgtgcggccg cgagatgcgg cgcaggcgct cgccgtgcgg
    14701 cacgtccgag ccgaccgcga ggtccaggtg gtcgatcagg ttgagcgcga tgaacggcca
    14761 cgcaccctgg ttcgccggct cctcctgcgc ccagaggtac ttctcggcgt tcgggtactt
    14821 cgcgatctcg gcctggatct ccgcacccgg cagcgggtac aggcgctcca ggcggatgat
    14881 cgccgtctcc gtgtcgccgc gcttctcccg ctcggcgtcc aggtcgtagt acagcttgcc
    14941 ggagacgaag acgaccttgc ggacgtcctc ggccttgacc gacgcgtcgc cgatcaccgg
    15001 gcggaagccg ccggtggtga actcctcgat ggacgaggcc gccgccttca gacgcagcat
    15061 cgacttcggg gtgaagacga tgagcggctt gtggtgcggg ttgtgcacct gccagcgcag
    15121 caggtggaag tagttcgacg gcagggtcgg catcgcgacc gtcatgttgt cctgcgcgca
    15181 catctggagg aagcgctccg ggcgggcgga cgagtggtcc gggccctggc cctcgtagcc
    15241 gtgcggcagc agcagcgtga cgccggaggt ctggccccac ttctgctcgg ccgaggagat
    15301 gaactcgtcg acgacggtct gcgcgccgtt gacgaagtca ccgaactggg cctcccagat
    15361 gaccagcgac tccggacggg ccagcgagta gccgtactcg aagcccatcg ccgcgtactc
    15421 cgagagcagc gagtcgtaga cgttgtaccg ggcctggtcg tcggccaggt acagcagcgg
    15481 ggtgtagtcc tcgccggtga cctggtcgac caggaccgcg tggcgctggc cgaacgtgcc
    15541 gcggcgggtg tcctggccgg cgagccggac cggggtgccc tccatcagca gcgaaccgat
    15601 ggccagggtc tcgcccatgc cccagtcgat cgtgccgttc tccaccgagg ccgcgcgacg
    15661 ctgcatctgc ggcatcagac gggggtggac ggtgatcgac tcggggatgt tgacctgcga
    15721 ctcggcgatc cgcttgacga cctcggcgga gaccgcggtc tccacggcca ccgggaacgc
    15781 ggcctgcggc tccgggacgt gcggggaggc gggctgcgag gtggcctcgc ggacctccgc
    15841 gaagaccttc tccagctggc cctggaagtc ctggagcgcc tgctccgcct cttccagcgt
    15901 gatgtcgccg cgaccgatca gcgactcggt gtagagcttg cgcaccgagc gcttcttgtc
    15961 gatcagggtg tacatctgcg ggttggtgaa ctccgggttg tcgccctcgt tgtgaccgcg
    16021 gcggcggtag cagatgaggt cgatcacgac gtccttgttg aacgcctgcc ggaactcgaa
    16081 ggcgagccgc gcgacgcgga ccacggcctc cgggtcgtcg ccgttgacgt ggatgatcgg
    16141 cgcctcgatc atgcgcgcca cgtcggtggc gtacatcgag gagcgcgagg actccggggc
    16201 ggcggtgaag ccgacctggt tgttgatcac cacgtgcacg gtgccgccgg tgcggtagcc
    16261 gcgcagctgc gacatgttga gcgtctcggc gacgacgccc tggcccgcga aggccgcgtc
    16321 gccgtggagc gcgaccggca ggaccgtgaa gtccgtgccg cccttgttga tgatgtcctg
    16381 cttggcgcgg gcgatgccct ccaggaccgg gtcgaccgcc tccaggtgcg aggggttggc
    16441 ggccagcgag accttgatct gctcgccgtc cagaccggtg aaggtgccct cggcgcccag
    16501 gtggtacttg acgtcgccgg agccgtgcat cgagcgcggg tcgagattgc cctcgaactc
    16561 gcggaagatc tgggcgtacg acttgccgac gatgttcgcc aggacgttca gccggccgcg
    16621 gtgggccatg ccgatgacga cctcgtcgag gcgggcctcg gcggcggagt cgatgaccgc
    16681 gtcgagcagc gggatgacgg actcgccgcc ctccagcgag aaccgcttct ggccgacgta
    16741 cttcgtctgc aggaaggtct cgaacgcctc cgcggcgttc agccggcgca ggatccgcag
    16801 ctgctcctcg cgctcgggct tcgggcgcgg gcgctcgacc cggtcctgga gccacttgcg
    16861 ctgcttcggg tcctggatgt gcatgaactc gatgccggtg gtgcggcagt acgactcgcg
    16921 gagcacaccg aggatgtcgc ggagcttcat catcgtcttg ccggcgaacc cgccgaccgc
    16981 gaagtcccgc tccaggtccc acagggtgag gccgtgctcg gtgatgtcga ggtcggggtg
    17041 cttgcgctgg tggtactcca gcgggtcggt gtcggccatg acgtggccgc ggacccggta
    17101 ggagtggatc agctcgaaga cccgcgcggc cttggtgacg tcgtcgtcgt gcgaggcgtc
    17161 gatgtccttg agccagcgga ccggctcgta ggggatgcgc agcgccttga agatctcgtc
    17221 gtagaactcg ttctcgccga gcagcagctg ggagaggacg cgcaggaact cgccggaggc
    17281 ggcgccctgg atgacccggt ggtcgtaggt cgacgtgagc gtcatgacct tcgagatgcc
    17341 gagcttgttg agggtgtcct gcgaggtgcc ctggaactcc gccgggtagt ccatcgcgcc
    17401 gacgcccatg atgaggccct gaccgggcat caggcggggc accgagtgga cggtgccgat
    17461 cccgccgggg ttggtcagcg aggcggtgac gccggtgaag tcgtccatgc cgagcttgcc
    17521 gatgcgggcg cgccggacga tgtcctcgta cgcctgccag aactcgaaga agttgagcgt
    17581 ctcggccttc ttgatggccg cgacgaccag ctggcggtcg ccgttcggct tcaccaggtc
    17641 gatggccaga cccaggttga tgtgctccgg cttgaccagg gtgggcttgc cgtccctctc
    17701 cgcgaaggag tagttcatcg acggcatggc cttgagggcc tgcaccatcg cgtacccgat
    17761 gaggtgcgtg aaggagatct tcccgccgcg ggcgcgcttg aggtggttgt tgatgacgat
    17821 gcggttgtcg aagagcagct tcaccgggac cgcgcggacg gatgtggccg tcggcagctc
    17881 cagcgaggcg ttcatgttct tcgcgacggc ggccgagggg ccgcgcagcg tcacgtactc
    17941 cggtcctgcc ggggcctcgg tggactcgtc ggccttcgcc ttgggcttgg cgggcgcggc
    18001 ggcgggcttc gccgccgcgg gcttcgccgg ggccggggcc gccggggcgg ccttggccgg
    18061 ggcgggctgc gcgggagccg ccggagcggc tgcgggcgcg gccttcaccg gagccggagc
    18121 ggccgccggg gcgggcgcgg cctcggccgc cggagccccc gaggccccgg cgccgggagc
    18181 gggcttgtcc gccgtgccgg tggcacccgg cttgtagtcg gcgaagaagt cccaccaggc
    18241 gcgatcgacc gaactgggat cctggaggta ctgctggtag atctcgtcga cgagccattc
    18301 attggcgccg aaagccgcgg ccgggttggt gcccgggctg gcttggtcgg tcgagatgct
    18361 cgagttactg ggggactgag acgacacggc ggcaaccgcc ctcttccgct tcacaaggtg
    18421 atggacagcg gaaatcaagg ctacgccccc cgaaccgttc cttgcagacc gggccggtgc
    18481 ttcgtcgtgc acatcacatc gaagggcggg tttcggcgca ggaaatggcg ggaaacaagc
    18541 gaggttccac tgcactccgg gtacgcagga ccgtgggtac ggtcctccga ccgtatcccc
    18601 ttgcggtccc cagctggcag gacacggatg aacgtgccct tccggttcga ccctatgtca
    18661 acgacgccgt caaccgcgct gctcggggat tcccgggagg gtgacctgga tgcggcaacc
    18721 ccgcgcggat tcggccaccc cgatccggcc gccgtgcaga tcgaccgccc agcgggcgat
    18781 ggccagaccc agtcccgtac cgccgtcgct gcccggaccg tgcggggacg gcgcctggcc
    18841 ccggttgaag cgctcgaaca cccggtggcg ctccgcctcc gggatgccgg gcccctcgtc
    18901 catgacctcc agctccagcg actcgggata caccccgcgc cgcgcgagca ccgtcacccg
    18961 gccgtgcggc gggctgtgct tgacggcgtt gtcgatgagg ttggcgacca cctggtgcag
    19021 ccgctcggcg tccgcgtgcg cggtgagctc cggcggcgag acgtccaggt gcagatggac
    19081 gtccgtacgg gagtgattgc ccgagcccga cgacagacgt cgctgggagg ccgcgagatt
    19141 ggcctctttc agtacgcccg agagatacgg ccacacctcg aaacggcgtg acttgagcgc
    19201 caccaccccg ttgtccagcc gcgacaggtc cagcagcgtc tcgaccagcc ggcccagccg
    19261 ctccgtctgc ttcagcgccg tgcgcatcgt ctccggatcg gcggcggaca ccccgtccac
    19321 cacgttctcc agcacggctc tcagcgccgc gatcggcgta cgcagctcat ggctgacatt
    19381 ggcgaccaac tccttgcggt gccggtcctc cgcctccaga tcgtccgcca tgcggttgat
    19441 cgtctgcgcc agatcgccca gctcgtcccg ccgcccggcg ccgctcaccc ggcgcgtgta
    19501 gtcgccgtgc gagatcgacc gggccaccgc tcgcatctcg tccagcggcg cggtcagacc
    19561 gtgcgccacg aactgcgtga tcagcagcgt cgcgatcacc gagaacacgg tgatgaactg
    19621 gaactcggtc cgggtccgca gggcgacgat cagcagcccg gtggtgatga acaccgagac
    19681 cacgacgagc gtgccgagct tggccttgat ggagaagggc cgcattccgg gccctggcca
    19741 ggtcatggcg ccggagtctc cagggcgtag cccacgccgt gcaccgtacg gatccgctcc
    19801 gcgccgatct tccggcgcag cgccttgatg tggctgtcga ccgtgcgggt gcccgaggcg
    19861 tccgcccagt cccacacctc ggccagcagc tgctcccggg agagcacggc gcgcggggtg
    19921 ttggcgaggc agacgagcag gtcgaactcg gtcggcgtga ggtggacgtc ctccgcgcgc
    19981 acccggaccc ggcgctgcgc gtggtcgatc tccagctcac ccaggcgcag tatcccgctg
    20041 cgcggggtca cggcggccag cgcggcccgc tccacccggc gcagcagcac gtgcacccgg
    20101 gcggccagct cccgcatgga gaacggcttg gtcatgtagt cgtcggcgcc gaccccgagc
    20161 ccgacgagca tgtcggtctc gtcgtcgcgt gccgtgagca tcagcaccgg taccggacgc
    20221 tgcgcctgca cccggcggca gacctccagg ccgtcgaagc ccggaagcat gatgtcgagc
    20281 accatcaggt cgggctgcca ggcctcggcc gcgtccacgg ccgcggggcc gtccagcgcg
    20341 gtctgcacca ggaagccctc cgcccgcagc cgggcggaaa tggcgtcgac gatcgtggcg
    20401 tcgtcctcga ccaccagcac ccggcgctga gcccccgggg tggccgcgac gccgttgtgg
    20461 gtggtgtgtg tctgttccat cgccccgccc ctgcccgttc tcgcgggagc cattcccccg
    20521 caaggcacgg tcttcgctcg tggttttcgt gggtgatccc gtgtgccggt cagcagcgta
    20581 aaggcagcgg agggctcccg gctacgcagg gtgttgcccg gccgtgcgag ttcacgccca
    20641 ccgggcaacc ggatcgtcgc ccttgtgccg gttggcccgt gccaccgccg ggtcccgcat
    20701 accgggaggg gggttcaggc ggcccggagt gcgagatgga ccacgtcggg cacacctcgg
    20761 gcaacggcca cctcttccgt cctaaccccg ctgaacccgg cattccgcaa cgcctgttcg
    20821 aaggccggcg acggctgagc ggaccagacg gcgagcacgc cgcccggggt cagccggtcg
    20881 tggcagtgcg ccagaccggc ggcggagtag aggtgtccgt tgtcctccgt gacggtccag
    20941 tcgggcccgt tgtcgatgtc caggcagagc gcgtcgtaac gctccgtggc cgtacggagg
    21001 tgggcgacga gatccgtgtg caggatctcg gtccgcgggt ccgccagcgc gggcccggag
    21061 atccggtcca gcggcccgcc ccggtgccag tccacgatcg cctgctcccg ctccacgacc
    21121 gcgatccgcc cccagcgctc ctcctcggcg gcccggacca gggagaagcc gacgcccagg
    21181 ccgccgatca gcaccgaggg gcccgtccgt ccggcgggca gcgccgcgag cgcggcgtcg
    21241 atcagcagcc gctcggagcg cccgtcggag gtgtccatca ggaagcagcc gttggcgatg
    21301 atctcgaagt gctccccgcg ctcccgcagc acgacctcgc cgaacggccc ttcgcggcgg
    21361 tcgaggacga cgggggcgtc ggccgggcgc gtcggcagcg ggtcgg
//
