LOCUS       NZ_CP079114            22919 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. WY228 chromosome.
ACCESSION   NZ_CP079114
VERSION     NZ_CP079114.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WY228
  ORGANISM  Streptomyces sp. WY228
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Volatile organic compounds produced by endophyte Streptomyces sp.
            WY228 mediate plant growth and salt stress tolerance by activating
            hormonal signaling and anthocyanin biosynthesis,
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JUL-2021) Key lab of biotechnology of medicinal
            plants, Jiangsu Normal University, No. 101 Shanghai Road, Xuzhou
            221116, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019287315.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 06:02:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,303
            CDSs (total)                      :: 7,213
            Genes (coding)                    :: 7,059
            CDSs (with protein)               :: 7,059
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 154
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 83 of 155
            Pseudo Genes (incomplete)         :: 99 of 155
            Pseudo Genes (internal stop)      :: 10 of 155
            Pseudo Genes (multiple problems)  :: 36 of 155
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:35:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4862889
            Orig. end                         :: 4885808
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP079114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22919
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="19"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22919
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22919
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12919](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12919)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     misc_feature    187..200
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    complement(929..941)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            complement(1191..1598)
                     /locus_tag="KV381_RS21225"
                     /old_locus_tag="KV381_21225"
     CDS             complement(1191..1598)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071667.1"
                     /locus_tag="KV381_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21225"
                     /product="DUF6336 family protein"
                     /protein_id="WP_249628410.1"
                     /transl_table=11
                     /translation="MSRGADGVLEPRLRLGGVVVRGAVYGGIVALCVVVAAFVLREHDA
                     RVDLLEATAFLGLLTGAVLLLTGLFFWASSSGEVLRWRDFFATGGPHDVVAIAGPALVR
                     TGVALLVPVPFAFGLGELVASAAYGSWLWGA"
     gene            1804..2001
                     /locus_tag="KV381_RS21230"
                     /old_locus_tag="KV381_21230"
     CDS             1804..2001
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007459987.1"
                     /locus_tag="KV381_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21230"
                     /product="hypothetical protein"
                     /protein_id="WP_256995130.1"
                     /transl_table=11
                     /translation="MRALLWPAFLVASPVLLIAGAPIRRRYLRHIYRDGAPPLLDKERG
                     HVSAHYFVATHPLFAWLGRE"
     gene            complement(2009..2464)
                     /locus_tag="KV381_RS21235"
                     /old_locus_tag="KV381_21235"
     CDS             complement(2009..2464)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642399.1"
                     /locus_tag="KV381_RS21235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21235"
                     /product="VOC family protein"
                     /protein_id="WP_218786001.1"
                     /transl_table=11
                     /translation="MEMTLQLTIDCSDPQRMVAFWSEALGYVPEPAPDGHATWRAYWAS
                     MGVPAEELPPGAGDVPESIVDPAGRGPRVWFQAVPEPKAAKNRWHFDLKVGGGRDVPLE
                     ERTRRVEAAVERLVEAGATVLRIKDEPEAGFYAAAMQDPEGNEFDVV"
     gene            complement(2699..3130)
                     /locus_tag="KV381_RS21240"
                     /old_locus_tag="KV381_21240"
     CDS             complement(2699..3130)
                     /EC_number="2.3.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014154592.1"
                     /locus_tag="KV381_RS21240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21240"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_030628175.1"
                     /transl_table=11
                     /translation="MRAAEPADVEPIAELRATVMRADLERLGRYDEHRVRQRLRDSFSA
                     RHTSVITVDGELAGCVTVRPAEDGLWLEHFYLAPRHQGRGLGSAVLNSLLERTDAQALT
                     VGLNVLNGSAARRLYERHGFVVESQDQVDVFLVRAPGGG"
     gene            complement(3224..4009)
                     /locus_tag="KV381_RS21245"
                     /old_locus_tag="KV381_21245"
     CDS             complement(3224..4009)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126602.1"
                     /locus_tag="KV381_RS21245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21245"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_030087458.1"
                     /transl_table=11
                     /translation="MTAQAPHPPIDTSKPHSARVYDALLGGKDNYPVDQQVAELLPVEA
                     KIGAHQQRAFMNRATAWLAGQGVTQFLDIGTGIPTEPNLHQTAQEIRPSARVVYCDNDP
                     IVLRHAEALLISRPEGVTDYVHADVREPAIILDAARETLDFDRPIALSLLGLLHFLPDA
                     EDPIGIIRTFTDAMAPGSYVVLSHGASDVNAEKGEQAGDEYKKGGIQLALRTREEFSRF
                     FEGLEIVAPGLVKAPEWYTGTPAPEQEHSGMYVAVARVP"
     misc_feature    4027..4042
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.7"
                     /tool="antismash"
     misc_feature    complement(4034..4049)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.18"
                     /tool="antismash"
     gene            complement(4067..5875)
                     /locus_tag="KV381_RS21250"
                     /old_locus_tag="KV381_21250"
     CDS             complement(4067..5875)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="KV381_RS21250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21250"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_218786002.1"
                     /transl_table=11
                     /translation="MSEAAPRPIDRHLFAGFLRRHRGAAVAVAGWSLLEAVPALASGLL
                     VAAALDRGFLAERPAEGFFWIGLLGAAMVFRALMTRTLTPWLGRIVEPLRDDLVTAVAA
                     GAVQRAAAGARDTAGAGVARLTVQVETVRSLVSALLRSARQLGVSLLMAFVGLAALSAP
                     VAALTLPPVLLTLLLCVPRLRVLARRQRRQLRAEERLTGVAGETFDGIRDVVACGARDR
                     VADELSARITDHRDAARAVARTASANTLLVSLGSHLPLLVLLLSASRLLDSGALSVGEL
                     LGATSYLVSGVAPALRSLVAVLGSWGVQLATVLSQLSRSTREARPGPPGGQGPALPPRT
                     RRTPRTPQTPRTPLTPLTPSSPDLSLVNVVYAYGPGAAPVIDGLSLDIPAGSHLTVVGP
                     SGAGKSTLTTLLAGLAGPDSGRLTLGGVPVTEVDRAWLHRAVTLIPQEAYVFTGTVRDN
                     LRYLRPQARDTDILASATAVGARTLVDRLGGLDAPVGLDGPPLSSGERQLVALARAHLS
                     PASIVLLDEACCHLDPAAEERAERAFATRGTTLVVVAHRISSALRAPRVLVLDGERTAV
                     GTPAQLLDSSPLYADLVGHWVSAGAP"
     gene            complement(5872..7659)
                     /locus_tag="KV381_RS21255"
                     /old_locus_tag="KV381_21255"
     CDS             complement(5872..7659)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="KV381_RS21255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21255"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_078611280.1"
                     /transl_table=11
                     /translation="MTSPRRLVWDATARTRGWFVLASATAVLGSAGTLAFPWAMARALD
                     AVVARRSVTGPVLVCAALLALVVTTGALQTLANGGYGSGTVAALRRSLARRALDAGVPG
                     TADFPAGDLAGRLSAGCAQAGSAGVTLVTASTAVLTSLGGVVALWLLDWRIGLCFSLGV
                     PPLALIARMFMNRGSGLFLRYQETQGRISALLLEALGGARTIGASGTAAAETRRVLDPL
                     PELSRTGHRVWALQRDTGWQVGLLIPAVEVLVLCAGGLALLRGDISAGELAAVVGYTAL
                     AMAALDQLDALFALGMSAAGARRVAEVVDQPVPAPGTRARPAGGSGTVTLSGVTVRSGA
                     RTVLDAVDLVVPAGTALAVVGRSGAGKSTLAALIGRLREPDAGLVAIDGVPLRELSPQA
                     LRAAVGYAFERPALLGTTVAGMIAFARPDASHEEVTAAAASARADDFIARLPGGYDTPL
                     TEAPLSGGEVQRLGLARALVHDPAVVVLDDALSSLDTATEARVGSALASAWSGRTRVLI
                     AHRVSTAARADLVAWLEDGRVRALGPHADLWQLDDYRALFAASTGPETAPDRDTGSGAE
                     AWTGRDTPPHTNPHAQEPV"
     gene            complement(7801..7932)
                     /locus_tag="KV381_RS21260"
                     /old_locus_tag="KV381_21260"
     CDS             complement(7801..7932)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038157.1"
                     /locus_tag="KV381_RS21260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21260"
                     /product="ALQxL family class IV lanthipeptide"
                     /protein_id="WP_189460106.1"
                     /transl_table=11
                     /translation="MIDNTMTVDVDELQTLEGEESVALAGCTRTCTWTCSITSIEQQ"
     CDS_motif       complement(7855..7932)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MIDNTMTVDVDELQTLEGEESVALAG"
                     /locus_tag="KV381_RS21260_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7801..7854)
                     /prepeptide="core"
                     /locus_tag="KV381_RS21260_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.70"
                     /molecular_weight="1835.1"
                     /monoisotopic_mass="1833.8"
                     /core_sequence="CTRTCTWTCSITSIEQQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MIDNTMTVDVDELQTLEGEESVALAG"
                     /leader_location="[7854:7932](-)"
                     /alternative_weights="1853.1"
                     /alternative_weights="1871.1"
                     /alternative_weights="1889.1"
                     /alternative_weights="1907.1"
     gene            complement(7929..10004)
                     /locus_tag="KV381_RS21265"
                     /old_locus_tag="KV381_21265"
     CDS             complement(7929..10004)
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.5"
                     /locus_tag="KV381_RS21265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21265"
                     /product="S9 family peptidase"
                     /protein_id="WP_218786003.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-05, bitscore: 22.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 5e-21, bitscore:
                     73.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRPERISFRFSARSRFAACLVATADGALAPGWWDLDGTHPPYA
                     GDPPRYREGAPAETTATQVLPTEDGGLLRLRGAAGSGRHLLLLSRPAPASAAATATGTS
                     LAGPRVPYSAERELRGPSPAGPGLKDPAPPEELAVEARGLRLVPGGPPGTLALAVETTH
                     DGRTRVRRVRATPLRLSDPVILPGRVTALLPLDGTGRRYATDLEGPDGYRPVSLDLRDG
                     TWRALPSPANGRIHRLLLSAPASGLLLTASDPGDGRLRIAHAALGDRTRLSFPDRLNSL
                     DGAVLPLAADPAGERVALRVTRGARARLFLYDVGADRPRPAALPPGAFHPVAGWSTGGL
                     RVVYATPDRPTDLVTVPDTAAHPDPASTAAHPDPASYDAPSSSLGAPSNTPDAEGTSHA
                     ATEWFATPSGRFEAVVLGDRRTAPTVVVALHGGPEDHWTLGHDPVLARLSDAGAAVVAP
                     NQRGSTGYGRAHAEAIHGAWGVPDLADIRSLVRTLTEQRPPDAEPPVLLGTSYGGFLAL
                     LAVCADPYAWARCAVIAPFLSARGLRERSSPAVRALIDRHGLGEPPDDDLGPRDVERLA
                     HRIRVPLLALHGCDDPVVPVDETRRLRQALARAGGPQRALAPHDCLDIPGAGHHPLQER
                     GGAGLTDRLVSFLTARAPDRRRTLAPPELTVADAAVRHRRSPAVFGHITHDERTPP"
     gene            complement(10001..12919)
                     /gene="lanL"
                     /locus_tag="KV381_RS21270"
                     /old_locus_tag="KV381_21270"
     CDS             complement(10001..12919)
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="KV381_RS21270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21270"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_218786004.1"
                     /sec_met_domain="Pkinase (E-value: 1.2e-13, bitscore: 49.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7e-43, bitscore:
                     145.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDRDEHDGGSFFALDTGLLPGIVEGVLHRRGATQWTVEQGEFW
                     CSVRPRGHRSGEQGWKLHLSATPLSAALVLAVAADVLVEERASFKFAGALDRVALLTGG
                     RADRGGGGKFITVYPDDPELFRRLARRLHAATLGLRGPRILSDRPYAPGSLVHYRYGVF
                     GGVRTTTNDGDTDVRLRNPGGGLEKDRRQAWVTTPAWAPPPFPEPAASPEPTASPETTP
                     GPSQEQEKEKEKEPTGPRKRTPTRTPGRKSVRLNGRYMVAKAIRHAFKGGVYRATDETT
                     GRQVVVKEARAHVGVRMDGTDLQDTLRHEAETLEALAPLGFTPAAIEVFAQGGNLFLAQ
                     EFVPGRTLRDRLVEHPVRDLAEFLALGRQIVDIVAAVHGTGRVLRDLSPNNLMVTPEGR
                     VRLIDVEYLAPEGVPVRRGYTPGYVGPEVSSLRDYDFTAPTYAGDLYGLGAVLLHLATG
                     VDMLLVPDDRPIGDRTQALITAAVADHAWAAPLLPLLLALCAPLPEERWELPRVRKALA
                     ELPGSGHRPTGGGSGRNGETGGTRVTGPGATGGSGVPALSGEERERLIADGIAYLLRTR
                     PGSGGHLWDVSAFGATTDPLNVQYGSAGVLAVLTRAAAAGAGPDVRRGVAELTEWTRRR
                     LAGLPTGRTPDGTLLPGLHFGRSGTAWALLDAALLLGDEDVAAEASALARAVPVDWPNR
                     DICHGAAGAGMTQLHFWRTTGDPVFRDRAVACADAIIAAAEDHPAGVIWPVPAAFDSNL
                     AGARHYGFAHGIAGIGAFLLAAGVAAEHEGLLWAAGRAGDTLVNLARFEHGRAVWPAGD
                     RDADGPVGQTHWCSGSSGIGTFLVRLWARTGDERHREAAVQAAAGVREAMWLSSPAACH
                     GLAGNAEFLLDMSAALDDPRYRDRAGELAACIHTRAVRRDGLLVVPDESLEAVTGGYQT
                     GVAGTVGMLLRLRDGGPRLWMPDTPELFAPADRHPRTAVGVR"
     misc_feature    complement(13002..13018)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.18"
                     /tool="antismash"
     misc_feature    complement(13129..13143)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            13254..14474
                     /locus_tag="KV381_RS21275"
                     /old_locus_tag="KV381_21275"
     CDS             13254..14474
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KV381_RS21275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KV381_21275"
                     /product="sensor histidine kinase"
                     /protein_id="WP_143665917.1"
                     /transl_table=11
                     /translation="MVIATALYRGSHLVAGGVVVAQHQRDRLFPWLALSAAIASTALIW
                     FMAARHRRLVPWVVGLDVLVIGCLLPFGAYAWGGARTQESVAWVMLLGGSASAMAAVAF
                     GARLLAVAVALLVATHLAGYLMVAADAAVTGAHLNALVFSAVVSWVLTWYLCRQGEQVD
                     SANRRALAAEAQRARFAERVAHHNALHDTVLATLTAIARGGVDANTSMMRERCAREAAY
                     LRRLVEQADDREPASEVRAALEESVRAAEALGLRVTARYHEPPAVPGEIALAMARATTE
                     ALNNVRCHAGTGHAFLTAVGDSGRLIVTVVDRGRGFDTGSAGPEGAGGPGGPDDAGGAA
                     GPRASGGAAGPGVSGGPEGPVGPVRQATGGIGLDRSVYARMRGVGGRAFVDSAPGEGVR
                     VELRWPG"
     gene            14462..15094
                     /locus_tag="KV381_RS21280"
                     /old_locus_tag="KV381_21280"
     CDS             14462..15094
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010061151.1"
                     /locus_tag="KV381_RS21280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21280"
                     /product="response regulator transcription factor"
                     /protein_id="WP_030087470.1"
                     /transl_table=11
                     /translation="MAGVITVAVVDDDRMLRDGIRSWFAGVEELDLVACAATVDELLAG
                     PWAPPDVVLLDLMLRDDRPPADNIRRLRAAGSRVLMISVVADRDRIVAAVTDGADGFLT
                     KDHELSVLVEAVREIAAGRTAHSPELAFALAYDRGSTRPRLSPQEREVLVGYASGLTLK
                     ATARRAGITVNTAKYYLDRVKAKYQEAGRPTYTKIDLATRVREDGWR"
     gene            15335..16237
                     /locus_tag="KV381_RS21285"
                     /old_locus_tag="KV381_21285"
     CDS             15335..16237
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967252.1"
                     /locus_tag="KV381_RS21285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21285"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_030628187.1"
                     /sec_met_domain="Abi (E-value: 1.7e-15, bitscore: 55.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPAGSRYDEQGRNGQGGRFGWLGELAVVVALVVVGVLVVSIAG
                     FVVAELLDAGPESADSELFFEDPVADLVVQLLGIAIGIPIVLLAVRLLGRRPAGTVSSV
                     VGRIRWGWLLRCAAVAFPLMIVQIGLLIAWTWNDEPLGETGTGFPGWPVFLLSLAVVLA
                     LVPFQAAAEEYVFRGWLVQVIGRAVRTPWPAIVIASLLFALAHGFGELSGFLLLLYSAL
                     WWGWLVIRTGGLEAVIVMHVANNLLAFGLAAGFGELASTETAADAPWQAMVVELVFAPL
                     YCLTMARIADRRGVERVSP"
     gene            16275..16613
                     /locus_tag="KV381_RS21290"
                     /old_locus_tag="KV381_21290"
     CDS             16275..16613
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126611.1"
                     /locus_tag="KV381_RS21290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21290"
                     /product="hypothetical protein"
                     /protein_id="WP_193463750.1"
                     /transl_table=11
                     /translation="MKRTRLWKSFVPVVVNLLLGIPAVVPVFLIWYVLSNGPLAELGWT
                     QREPTENDGMWLWLVIVVPVVACFGGLWTLLNLWMRRRLIAAASPYPYWSLAVTLTLAP
                     FLLGAAFG"
     gene            complement(16501..17004)
                     /locus_tag="KV381_RS21295"
                     /old_locus_tag="KV381_21295"
     CDS             complement(16501..17004)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155690.1"
                     /locus_tag="KV381_RS21295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21295"
                     /product="hypothetical protein"
                     /protein_id="WP_218786005.1"
                     /transl_table=11
                     /translation="MPTPLMGLFLLISAVAGAACVLVLVLLLKNPPRSPARIFGVLALL
                     CGFAATAGYCCGWFSVTLGGPFPALCEDVNRSGAPLAGLHQEFWPLRNACLYSDGSAVE
                     HLPPSVNVLLRTAAGLAAALACTAALLSRRRRPGGTGRGSASPPATSTGTGTPQRSAGA
                     ASTG"
     gene            complement(17107..17715)
                     /locus_tag="KV381_RS21300"
                     /old_locus_tag="KV381_21300"
     CDS             complement(17107..17715)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018958676.1"
                     /locus_tag="KV381_RS21300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21300"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_218786006.1"
                     /transl_table=11
                     /translation="MTPETRRGYAKGRAKRTEILDQAMAQFGEAGYRGASLRVIATRCG
                     ISHPGLLHHFPTKEALLLAVLQRRDDVDDEWLSLGVTRGIDHLRRLTDLAELNAKRRGI
                     VELFSVVAAEATAPDHPAHAYFEARYRTSVANTERAYLQARQAGELRDDVDPSAAAQQL
                     IALMDGLQIQWLISDCTTDMAGVLRAHVQAQLTVPFRPA"
     misc_feature    complement(17774..17789)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.78"
                     /tool="antismash"
     gene            17861..20143
                     /locus_tag="KV381_RS21305"
                     /old_locus_tag="KV381_21305"
     CDS             17861..20143
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007450053.1"
                     /locus_tag="KV381_RS21305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21305"
                     /product="glycoside hydrolase family 3 N-terminal
                     domain-containing protein"
                     /protein_id="WP_218786007.1"
                     /transl_table=11
                     /translation="MGLKPPYLDPELPVGERVADLLGRMTLPEKVGQMLQLNAKEGVRH
                     LVEDLHAGSILHASPDRVREAAALTAKTRLRIPLLVAEDCIHGHSFWEGATIYPTQLGM
                     AATWDPELVERIARATAVEVAATGVHWTFSPVLCITRDLRWGRVSETFGEDPLLIGELA
                     SAMVRGYQGDGLDDPTAILACAKHFAGYSETQGGRDASEADISRRKLRSWFLPPFERVA
                     KEGCRTFMLGYQSMDGVPITVNNWLLNEVLRGEWGYTGTLVTDWDNVGRMVWEQKVYAD
                     YAQASAAAVRAGNDMVMTTSNFFEGAQEAVAQGELGETEIDAAVRRILTLKFELGLFEN
                     PRHPDADRQAAFIGSAAHAELNLEAARRSLVLLTNDGTLPFAGGLAAGGEGRASGPGPR
                     TVAVIGPNADDAQTQLGDWAGSSGQADWLPEGQPRAMIRTVLDGFRDQVPADWTVSYAP
                     GARILDVGPDPEGEFFPDGQPRPEVVHPAAPDAELIAEAVAAAEAADHVVAVVGDRIEL
                     IGEGKSTATLELVGDQVALLDALAATGKPLVVVVISSKPLVLPPSALGAAAIVYAANPG
                     MLGGQAVAELLLGLIEPTGRLPLSFARHAGQQPTYYNQVRGQHGTRYADLTQRPAFAFG
                     EGLSYTTVDYTGLEVLTAVVDESETVRARVTVTNTGARPALETVQVYVSDTVTSVTWAE
                     KELKAYRQVELAPGQSREVLFELPAADCTLVDAAGRRIVEPGRFELLVGPSSRDEALLR
                     GEFTVKG"
     gene            complement(20248..20979)
                     /locus_tag="KV381_RS21310"
                     /old_locus_tag="KV381_21310"
     CDS             complement(20248..20979)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071682.1"
                     /locus_tag="KV381_RS21310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21310"
                     /product="hypothetical protein"
                     /protein_id="WP_030628194.1"
                     /transl_table=11
                     /translation="MRISKNLIGLAAVGILAAGCGSSSSDDSAGSSGSAGSSGSAGQAP
                     SEEAKAPEPGADLAVPVTGPQPDVLASSSDPKLKVTPKPANGASFTEKVEHKLQEDLLG
                     RLKVPGKTSANCPDGVTQKASAVSICNVTYEGATVPYEIEISEKYKPGSFLTFYNSTPK
                     KGLLVAKNAYDRLWTANKGRSDISKLSCEELPAAKAVDEETETGFHCQYWGKYAGEDGK
                     GGFVKLGIKVNRHNVDFFEVR"
     gene            complement(21127..21672)
                     /locus_tag="KV381_RS21315"
                     /old_locus_tag="KV381_21315"
     CDS             complement(21127..21672)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024803.5"
                     /locus_tag="KV381_RS21315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21315"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_373461071.1"
                     /transl_table=11
                     /translation="MRIGEAAAAAGCTPRALRLYEERGLLPPPGRTASGQRDYRPAEVA
                     LLRVIRELLGSGFTIEDLRSCADRLHLLTEDPPPRCGAADAPEGSGSGVVGRRLAALDA
                     EIARLVRLREDLARRVFGDDARRSAPEPAAEPTAGQIPEPAAPPPPATSPVRAPTTAPV
                     PAPVTGPTVTVGPRVLLD"
     gene            complement(21708..22745)
                     /locus_tag="KV381_RS21320"
                     /old_locus_tag="KV381_21320"
     CDS             complement(21708..22745)
                     /NRPS_PKS="Domain: PKS_ER (78-342). E-value: 6.7e-20.
                     Score: 63.4. Matches aSDomain:
                     nrpspksdomains_KV381_RS21320_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009338599.1"
                     /locus_tag="KV381_RS21320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_21320"
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_103537722.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.6e-18, bitscore:
                     64.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAVPHPPRTAREVRLTSVPEGLPAPENFAVVEAPLPAPGAGQVL
                     VRNRAFLVFPGLRTLIGGEVDGVPLPALRSGDTLFGPAVGEVVAAAEGGPLRPGDIVTH
                     LQGWRDHAVVDAAHCAPVRDVLPDPVAHLAQGSSAYGALTRLAGVRAGDTVLVTGAAGA
                     VGTLAGQIARLLGAGRVIGSTRSAGKAERLVAELGYDAVLLPGTDTPFAAQLAAAAPEG
                     IDVLLDNVGGEQLAAAVHAARQGARFALVGALSGQLSARRAGGSAPVEIDSFRVITRGV
                     SLRGYSGADHPDVEQEWTGRFGQWLRSGEIVFPHTRIPGIDRAPQALQELIGGRHFGAV
                     VVELP"
     aSDomain        complement(21720..22511)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KV381_RS21320_PKS_ER.1"
                     /evalue="6.70E-20"
                     /label="KV381_RS21320_PKS_ER.1"
                     /locus_tag="KV381_RS21320"
                     /protein_end="342"
                     /protein_start="78"
                     /score="63.4"
                     /tool="antismash"
                     /translation="LFGPAVGEVVAAAEGGPLRPGDIVTHLQGWRDHAVVDAAHCAPVR
                     DVLPDPVAHLAQGSSAYGALTRLAGVRAGDTVLVTGAAGAVGTLAGQIARLLGAGRVIG
                     STRSAGKAERLVAELGYDAVLLPGTDTPFAAQLAAAAPEGIDVLLDNVGGEQLAAAVHA
                     ARQGARFALVGALSGQLSARRAGGSAPVEIDSFRVITRGVSLRGYSGADHPDVEQEWTG
                     RFGQWLRSGEIVFPHTRIPGIDRAPQALQELIGGRHFGAVVV"
     CDS_motif       complement(22230..22292)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KV381_RS21320_0001"
                     /evalue="9.40E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="KV381_RS21320"
                     /protein_end="172"
                     /protein_start="151"
                     /score="11.9"
                     /tool="antismash"
                     /translation="GDTVLVTGAAGAVGTLAGQIA"
ORIGIN
        1 ccgaacaagg tcatggacgc gaagttcggc aagaccgacg ccggccgcgt actcctggag
       61 gccgacctgg agatgaagca cgacttcagc gaggccgtga accccgacaa gcaccccggc
      121 gccaaacggt actgggacac cgcgccgcgc cggaacggca tgccgtgctt cccgggtgta
      181 cggatgtgga tcgagcccaa gcccgcccag gtccgtgagg aggacggcgg gatccacatc
      241 ctcgacgcgc ccctcaaggt cagcacccag tggctcgacg tggactacac cgtccccggc
      301 tccaccgagt gcacggacct ctccgacgcg gagaagaagg cgatcgagcg gtccatcgcc
      361 acgaacgtca tgccgctcgt ggaggagcgc gtcaacaccg accgcgacta cgccgacctg
      421 cgggccgtgt acaccgcccg ggtcgccgcc gagtacatcc ggcagcagga cgccaagaag
      481 cccacggact tccgcgcgat catcgacagc aacgacgtga ccccgtggac gctgcgcgac
      541 cccaacaagg actggacccg tgagcaggtc tggaaccgct acatggactc gatcaagaag
      601 gggatcgagt ggttcgagct gaagtacggc ggcaaggtct acaaccaggg agtcggcggc
      661 gtcgacttct cgaagcagcc gaagcggaac atcccgaagg cccagttcga ggcggagaac
      721 cgggacctgg gcaacaccgt caccaactcc cgtaagtccg acgacgcttc gtaccgcgac
      781 ctcgacacgg tctacctcgg cgcgggcccc gcggacgagg gaagcggcga ggacccgggc
      841 ggcgacccca ccccgacgcc gaccccgtcg gaccccggca agccgaccga cccgccgtcg
      901 tccccggccc cggaccccac cacccccggt gaccacggca ccccgacccc gcccggcaac
      961 aggccggacc cggacggcga cctcgccgac accggcagca gcgccccggt cggcctcatc
     1021 gcgggcgccg ccgccgcgct cgcggtggcc ggcggaacgc tgatgtggtg gatgcgccga
     1081 cgccgcggga ccgtccagga gtagccgtac gggggcagta cgcaccgtga gagcgaaggg
     1141 ctccacccgc accccgggtg gagcccttca ccgcgctgta cggggcgggc tcaggcaccc
     1201 cacagccacg agccgtacgc cgccgacgcg acgagctcgc cgagaccgaa ggcgaacggc
     1261 accggcacca gcagggcgac accggtgcgg accagggccg gtccggcgat ggcgaccacg
     1321 tcatggggac cgccggtcgc gaagaagtca cgccagcgca ggacctctcc ggagctgctc
     1381 gcccagaaga acagtccggt cagcaggagg accgcgccgg tcaggagccc caggaaggcg
     1441 gtcgcctcca gcaggtcgac acgggcgtcg tgctcccgca ggacgaacgc ggcgacgacc
     1501 acgcagagcg cgacgattcc gccgtacacc gcgccacgca ccacgacacc gccgagccgc
     1561 agccgcggtt cgagcacccc gtccgcccct ctgctcatgc ggaccatgtg cgtgccccct
     1621 gtcgtcaccg tgccgtcgtg cctggcgtgc ccggcgtgtc tgtcgcgtct gtcgcgcccg
     1681 tggtcacgac gcggcgaagt ctacgaagaa ggcgtgttgc cgcacgagac gccggacccg
     1741 gcggaccagc acactgaggg catgcggtac gagaagcgat ccgaaagaat caggatcagg
     1801 gccgtgcggg ctctgctctg gccggccttc ctcgtcgcct cacccgtgct gctgatcgca
     1861 ggagcgccga tccgccgccg ctacctccgc cacatctacc gcgacggggc cccgcccctg
     1921 ctcgacaagg agcgcggcca cgtcagcgcc cactacttcg tcgctaccca cccgctcttc
     1981 gcatggctcg gccgggagtg aacggccttc agacgacgtc gaattcattg ccctcgggat
     2041 cctgcatggc ggcggcgtag aagccggcct ccggctcgtc cttgatccgc agcacggtgg
     2101 cgccggcttc gaccagccgt tccaccgcgg cctcgacccg tcgggtgcgt tcctccagcg
     2161 ggacgtcacg gcccccgccg accttcaggt cgaagtgcca ccggttcttg gcggccttcg
     2221 gctccgggac cgcctggaac cacaccctcg gcccccgccc ggcaggatcg acgatcgact
     2281 ccggtacgtc cccggcgccg ggcggcagct cttctgccgg cacccccatc gacgcccagt
     2341 aggcacgcca cgtggcatgc ccgtccggcg cgggctcggg aacgtaaccc agggcctcgg
     2401 accagaaggc caccatcctc tgcgggtcgg agcagtcgat cgtcagctgc agcgtcatct
     2461 ccatgccccg agcgttccag acggggccga cagccacccc tactgcacct ccgcccggtc
     2521 cccggtcgac gacttcgggc cggaggtggt gttgccgaag tacgtccagc gccaggtccc
     2581 ggacgtggtg gccttccgcg cgggctccgg cgcggcgttg accgtgatcg gtcctcgcgg
     2641 ctgactgtag gaccggggag ggccgtacgg ggttgtgcgc ggtgcggcag cgatgcggtc
     2701 acccgccgcc cggcgcgcgc accaggaaga cgtcgacctg gtcctgcgac tcaacgacga
     2761 agccgtggcg ttcgtagagc cgacgggcgg cactgccgtt caggacgttc aggccgacgg
     2821 tcagggcctg tgcgtccgtt cgctccagca gcgagttcag cacggcggat ccgaggcctc
     2881 ggccctgatg cctcggggcc aggtagaagt gctccagcca cagtccgtcc tcggcgggcc
     2941 ggaccgtcac gcagcccgcg agctcaccgt cgaccgtgat caccgatgtg tgccgcgcgg
     3001 agaacgagtc ccgcagccgc tgccgtaccc ggtgctcgtc gtaacgcccg aggcgttcca
     3061 ggtccgcccg catgaccgtg gcccgcaact ccgcgatcgg ctcgacgtcg gccggttccg
     3121 cggcgcgcag cgcccagccc ctggccggtg ccggggcggc ccgcgcgggc accgccgtgg
     3181 tcggccgcgt accgctctcc ggccgccagg aggccttcac cacctacggg acccgggcca
     3241 ccgcgacgta catgccgctg tgctcctgct cgggcgcggg ggttccggtg taccactccg
     3301 gggccttcac caggccgggg gcgacgatct ccaggccctc gaagaaccgg gagaactcct
     3361 cccgtgtccg cagggccagc tggatgccgc ccttcttgta ctcgtccccg gcctgctccc
     3421 ccttctccgc gttcacgtcg gacgcgccgt gggacagcac gacgtaactg ccgggggcca
     3481 tggcgtccgt gaacgtacgg atgatgccga tcgggtcctc ggcgtccggg aggaagtgga
     3541 gcaggccgag gagcgacagg gcgatcgggc ggtcgaagtc cagggtctcg cgggccgcgt
     3601 cgaggatgat cgcgggctcg cggacgtcgg cgtggacgta gtccgtgacg ccctccggcc
     3661 ggctgatcag cagcgcctcc gcgtgacgca ggacgatggg gtcgttgtcg cagtagacga
     3721 cccgggccga ggggcggatc tcctgggccg tctggtgcag gttcggctcg gtggggatgc
     3781 ccgtgccgat gtccaggaac tgcgtcacgc cctggcccgc cagccaggcg gtcgcccggt
     3841 tcatgaaggc gcgctgctgg tgagcgccga tcttcgcctc gacgggcagg agttcggcca
     3901 cctgctggtc caccgggtag ttgtccttgc cgccgagcag cgcgtcgtag acccgcgccg
     3961 agtggggctt gctggtgtct atcggggggt gaggcgcctg tgccgtcata ccgaactcca
     4021 gatacacgtg gtgtggacca ttcagtcgac gcagtctgcc acacgcctac ggagccccgg
     4081 cggagaccca gtgacccacc agatccgcgt agagcgggct gctgtcgagg agttgggcgg
     4141 gagtgccgac ggccgtgcgc tcgccgtcga gtaccaggac gcgcggcgcg cgcagcgcgg
     4201 agctgatgcg gtgcgccacc acgacgagcg tggtgccccg ggtcgcgaag gcccgctcgg
     4261 cccgctcctc ggccgccggg tcgaggtggc agcacgcctc gtccagcagc acgatcgacg
     4321 cgggggacag atgtgcgcgg gccagggcca cgagctgccg ttcaccggag gagagcgggg
     4381 gcccgtccag cccgacgggc gcgtccaggc cgccgagccg gtccacgagg gtccgggcgc
     4441 ccacggccgt cgccgacgcg aggatgtcgg tgtcccgcgc ctgtggacgc aggtagcgca
     4501 ggttgtcccg cacggtgccg gtgaacacgt acgcctcctg cgggatcagg gtcaccgccc
     4561 ggtggagcca ggcccggtcg acctccgtca cgggtacgcc ccccagggtc agccggccgc
     4621 tgtccggccc ggccagcccg gccagcagcg tggtgagagt ggacttcccc gcaccgctcg
     4681 gcccgacgac cgtcagatgt gagccggccg ggatgtcgag ggagagcccg tcgatgacgg
     4741 gtgccgctcc cgggccgtac gcgtagacga cgttcaccag ggacaggtcc ggggaactcg
     4801 gggtcagcgg ggtcagcggg gttcgcgggg tctgcggggt tcgcggggtc cgtcgggttc
     4861 gcggggggag ggccgggcct tgaccccccg gggggccggg ccgcgcttca cgtgtcgagc
     4921 ggctcaactg gctcagtacg gtcgccagtt gcacgcccca ggagccgagt acggcgacga
     4981 gcgagcgcag ggccggagcc actccgctga ccaggtagct ggtcgcgccc agcagttcgc
     5041 ccaccgacag cgcaccgctg tccaggagcc gtgaggccga caacagcagg accagcagcg
     5101 ggagatgact gcccagcgac accagcaggg tgttggccga cgcggtccgg gcaaccgccc
     5161 tggccgcgtc ccggtggtcg gtgatccggg cggacagctc gtcggccacc cggtcccggg
     5221 cgccgcacgc gacgacgtcc cggatgccgt cgaaggtctc gcccgcgacg cccgtgaggc
     5281 gctcctccgc ccgcagttgg cggcgctggc ggcgggcgag gacgcggagg cgagggacgc
     5341 agaggagcag ggtgagcagg accgggggca gggtgagcgc cgccaccggg gcggacaggg
     5401 cggccaggcc cacgaacgcc atcagcaggg agacgcccag ctgccgggcc gagcgcagca
     5461 gggcggacac cagcgaccgc acggtctcga cctgtaccgt cagccgggcc acgcccgcgc
     5521 ccgccgtgtc ccgggccccc gccgccgcgc gctgcacggc ccccgctgcc accgccgtca
     5581 ccaggtcgtc ccgcagcggt tccacgatcc gccccagcca cggtgtcagg gtccgggtca
     5641 tcagggcgcg gaagaccatc gcggccccga gcaggccgat ccagaagaag ccttcggcgg
     5701 gccgttccgc gaggaagccc cggtccaggg cggcggcgac gagcagcccg gaggcgaggg
     5761 ccggaaccgc ctccagcagg gaccatcccg ccaccgcgac cgccgccccg cggtgccggc
     5821 gcaggaaccc ggcgaacagg tgccggtcga tggggcgcgg ggctgcctcg ctcataccgg
     5881 ctcctgggcg tgcgggttcg tgtgcggggg cgtgtcccgg ccggtccacg cttcggctcc
     5941 ggaccccgta tcgcggtccg gggcggtctc cgggccggtg ctcgccgcga acagggcccg
     6001 gtagtcgtcg agttgccaca gatccgcgtg cgggcccagg gcgcggaccc ggccgtcctc
     6061 cagccaggcc accaggtcgg cccgcgcggc ggtcgacacc cggtgggcga tcagcacccg
     6121 ggtgcggccc gaccaggccg aggcgagcgc ggagccgacc cgtgcctccg tggcggtgtc
     6181 caggctcgac agcgcgtcgt ccaggacgac caccgccgga tcgtggacca acgcccgggc
     6241 gagccccagg cgttggacct ctccgccgga gagcggtgcc tccgtgagcg gggtgtcgta
     6301 gccacccggg aggcgggcga tgaagtcgtc cgcccgggcg gacgcggcag ccgccgtcac
     6361 ctcctcgtgg gaggcgtccg ggcgggcgaa ggcgatcatc ccggccaccg tcgtgcccag
     6421 cagcgcgggc cgctcgaagg cgtagccgac ggcggcgcgc agggcctggg ggctcagctc
     6481 ccgcagcggt acgccgtcga tggcgaccag gcccgcgtcg ggctcccgca gtcgcccgat
     6541 cagcgccgcc agggtgctct tgcccgcccc ggaccggccg accaccgcga gcgccgtgcc
     6601 cgccgggacg acgaggtcca cggcgtccag gacggtccgg gcgcccgaac ggaccgtcac
     6661 ccccgacagg gtcaccgtgc cggagccgcc cgccgggcgc gcgcgggtgc cgggggccgg
     6721 gaccggctgg tcgacgacct cggcgacccg gcgcgcaccg gcggccgaca tgccgagcgc
     6781 gaagagggcg tcgagctggt ccagcgcggc catcgcgagc gccgtgtagc cgacgaccgc
     6841 ggcgagttcg cccgcactga tgtcaccgcg gagcagggcg agacctccgg cacagagcac
     6901 cagcacctcc acggccggga tcagcaggcc cacctgccac ccggtgtccc gctggagcgc
     6961 ccagacgcgg tgcccggtgc gggacagttc cgggagagga tccaggaccc ggcgggtctc
     7021 ggccgccgcc gtgccgctcg cgccgatggt ccgggccccg ccgagcgcct ccaggagcag
     7081 ggcggagatc cttccctggg tctcctggta ccggaggaac agccccgagc cgcggttcat
     7141 gaacatccgg gcgatgagcg ccaacggcgg tacgcccagc gagaagcaga gcccgatccg
     7201 ccagtcgagc agccacagcg cgaccacccc gccgagcgag gtgagcaccg ccgtcgaagc
     7261 ggtgaccagc gtgacaccgg ccgacccggc ctgcgcgcac cccgcggaga gccgccccgc
     7321 gaggtccccg gcgggaaagt ccgccgtccc cggcaccccg gcgtccaggg cgcgccgggc
     7381 cagggaccgg cggagggcgg ccaccgtgcc ggagccgtac cccccgttgg cgagggtctg
     7441 aagggcaccg gtggtgacga cgagggcgag gagtgcggcg cacacgagga cgggaccggt
     7501 gacggaccgc cgggcgacga ccgcgtccag ggcccgcgcc atggcccagg ggaacgccag
     7561 cgtgccggcc gaccccagga cggctgtggc ggaggcgagg acgaaccagc cacgcgtccg
     7621 ggcggtcgcg tcccacacca gtcgccgggg agacgtcatc gaactccttc cggccgtccg
     7681 tggctcccgc ccgggggcgg gcgggcacgg gtgacgggca cggatcgcgg tgagtcgtgc
     7741 gtacgggaga cacggcgtgc gccggacggg cccgggaggg gcccgtccgg cgcacggctg
     7801 ctactgctgc tcgatgctgg tgatggagca ggtccaggta cacgtccggg tgcagccggc
     7861 cagcgcgacg gactcctcgc cctccagggt ctgcagctcg tcgacgtcga cggtcatggt
     7921 gttgtcgatc atggtggtgt cctttcgtcg tgagtgatgt gcccgaacac cgccggggac
     7981 cggcggtgtc gcacggccgc gtcggcgacc gtgagttcag ggggagcgag ggtgcggcgg
     8041 cggtccgggg cccgggccgt caggaagctc accagccggt cggtgagtcc ggcgccgccc
     8101 cgctcctgga gcggatggtg gcccgctccc gggatgtcga ggcagtcgtg gggtgcgagt
     8161 gcgcgctgcg ggccgcccgc ccgcgccagg gcctggcgca gccgacgcgt ctcgtccacc
     8221 ggcacgacgg ggtcgtcaca gccgtgcagg gcgagcagcg gtacgcggat gcggtgggcg
     8281 aggcgttcga cgtcccgggg gccgaggtcg tcgtccggcg gctcgcccag gccgtgccgg
     8341 tcgatcaggg cgcgcacggc gggcgacgac cgctcgcgca gtccgcgcgc ggacaggaac
     8401 ggggcgatca ccgcgcagcg tgcccaggcg tacgggtcgg cgcacaccgc cagcagcgcg
     8461 aggaagcccc cgtagctggt gccgaggagc acgggcggtt cggcgtccgg cgggcgctgc
     8521 tccgtgagcg tacggaccag ggagcggatg tccgcgaggt cgggcacgcc ccaggcgccg
     8581 tggatcgcct ccgcgtgggc ccggccgtag ccggtgctgc cgcgctggtt gggggccacc
     8641 accgccgccc cggcgtccga caggcgcgcg agcaccgggt cgtggccgag cgtccagtgg
     8701 tcctccgggc cgccgtgcag cgcgacgacg acggtgggcg cggtgcgccg gtcgcccagg
     8761 acgacggcct cgaaccgccc ggacggggtg gcgaaccact cggtcgcggc gtgcgaagtc
     8821 ccctccgcgt caggggtgtt ggagggtgct ccgaggctgc tggacggggc gtcgtacgag
     8881 gcggggtcgg ggtgcgcggc ggtcgaggcg gggtcggggt gcgcggcggt gtccgggacg
     8941 gtgaccaggt cggtgggacg gtccggggtc gcgtacacga cgcgcagccc gcccgtgctc
     9001 cagccggcga cggggtggaa cgcgcccggc ggcagcgcgg cgggccgggg ccggtccgcc
     9061 cccacgtcgt acaggaagag gcgggcccgc gcgccccggg tgacccgcag cgccacccgc
     9121 tcacccgccg ggtcggcggc cagcggaagg accgcgccgt ccagggagtt gagccggtcc
     9181 gggaagctga gccgggtccg gtcgccgagg gccgcgtggg cgatgcgcag ccgcccgtcg
     9241 ccggggtcgc tcgccgtcag cagcagcccc gaggccggtg ccgagagcag cagccggtgg
     9301 atgcggccgt tcgccgggga cgggagagcg cgccacgtcc cgtcgcgcag gtcgagggag
     9361 accgggcggt atccgtccgg cccttcgagg tccgtggcgt agcggcggcc cgtcccgtcc
     9421 agcggcagga gggcggtcac ccggcccggc aggatcacgg gatcgctcag ccgcagtggc
     9481 gtggcacgga cccgccggac gcgggtacgg ccgtcgtggg tggtctccac cgccagcgcg
     9541 agcgtgccgg gcggcccgcc gggcaccagg cgcaggcccc gcgcctcgac ggccaactcc
     9601 tcgggcgggg ccgggtcctt gagcccgggc ccggccgggg acgggcccct gagttcgcgc
     9661 tcggccgagt acggcacccg gggcccggcg agcgaagtcc cggtggccgt ggccgcggcc
     9721 gaggcgggcg cggggcggga cagcaggagc aggtggcggc cggagcccgc cgcgccgcgc
     9781 agtcgcagca gcccgccgtc ctcggtcggc agcacctggg tggcggtggt ctccgccggg
     9841 gcgccctccc ggtagcgggg cgggtcaccg gcgtacggag ggtgcgtgcc gtcgaggtcc
     9901 caccaccccg gggccagcgc gccgtcggcc gtggccacca gacaggcggc gaaccgggac
     9961 cgtgccgaga agcggaagct gatgcgctcc ggccgccggg tcatcgcacc cccaccgcgg
    10021 tacgcgggtg ccggtcggcg ggcgcgaaga gttccggagt gtccggcatc cagagccgcg
    10081 ggcccccgtc ccgcaggcgc agcagcatgc cgaccgttcc ggcgacaccg gtctggtagc
    10141 cgcccgtgac cgcctccagc gactcgtcgg gcaccaccag caggccgtcg cgtcggacgg
    10201 cacgggtgtg gatgcacgcg gccagctccc cggcccggtc gcggtaccgg gggtcgtcga
    10261 gcgcggcgga catgtcgagc aggaactccg cgttcccggc gagcccgtgg caggcggcgg
    10321 gggaggagag ccacatggcc tcccgcactc cggccgccgc ctgtacggcc gcctcccggt
    10381 ggcgttcgtc gccggtccgg gcccagagcc ggaccaggaa cgtgccgatg cccgaggagc
    10441 cgctgcacca gtgcgtctgc cccaccggtc cgtcggcgtc ccggtccccg gccggccaga
    10501 ccgcccggcc gtgctcgaac cgggccaggt tcaccagggt gtcgcccgcc cggccggccg
    10561 cccagaggag cccctcgtgt tccgccgcca ccccggcggc cagcaggaac gcgccgatcc
    10621 ccgcgatgcc gtgggcgaac ccgtagtggc gggctccggc gaggttcgag tcgaaggcgg
    10681 ccgggacggg ccagatcacc ccggcggggt gatcctcggc cgccgcgatg atcgcgtcgg
    10741 cgcaggcgac cgcccggtcg cggaagaccg gatcacccgt cgtccgccag aagtgcagct
    10801 gggtcatgcc ggcccccgcc gccccgtggc agatgtcccg gttgggccag tcgacgggga
    10861 ccgcgcgcgc cagtgcggac gcctcggcgg cgacgtcctc gtcgcccagc agcagggccg
    10921 cgtcgaggag cgcccaggcc gtgccggagc ggccgaagtg cagcccgggc aggagcgttc
    10981 cgtcgggtgt ccggccggtg ggaagaccgg cgagacgccg ccgtgtccac tccgtcagct
    11041 ccgccacccc gcgccggacg tcgggccccg cgcccgccgc cgcggcccgg gtgagcacgg
    11101 cgaggacgcc ggccgagccg tactggacgt tcagcgggtc ggtggtcgcg ccgaacgcgc
    11161 tgacgtccca gaggtgtccg ccgctgccgg gacgggtgcg gagcaggtac gcgatgccat
    11221 cggcgatcag ccgctcgcgc tcctcgccgg acagggccgg aacgccgctc ccaccggtgg
    11281 cgcccgggcc cgtcacccgg gttccgccgg tctctccgtt ccttccgctc cctccgccgg
    11341 tgggccggtg gccggatccg ggcagctccg cgagagcctt ccgtacccgg ggcagctccc
    11401 agcgttcctc ggggagcggg gcgcagaggg cgaggagcag gggcagaagc ggtgcggccc
    11461 aggcgtgatc ggcgaccgcc gccgtgatca gggcctgcgt acggtcgccg atcgggcggt
    11521 cgtcggggac caggagcatg tcgacacccg tcgccaggtg gagcagcacc gcgccgaggc
    11581 cgtagagatc gcccgcgtac gtgggagccg tgaagtcgta gtcccgcagc gaggacacct
    11641 cggggccgac atagccgggg gtgtacccgc ggcggaccgg gacgccctcg ggagccaggt
    11701 actcgacgtc gatgagccgg acccggcctt ccggcgtgac catcaggttg ttcggcgaga
    11761 ggtcgcgcag cacccgcccg gtgccgtgga cggccgccac gatgtccacg atctgccggc
    11821 ccagggccag gaactccgcg aggtcccgca ccgggtgctc caccagccgg tcgcgcagcg
    11881 tccgccccgg cacgaattcc tgggccagga acaggttgcc gccctgggcg aacacctcga
    11941 tcgcggccgg agtgaagccc agcggggcca gcgcctccag cgtctcggcc tcgtggcgca
    12001 gggtgtcctg gaggtcggtg ccgtccatgc ggacgcccac gtgcgcccgc gcctccttca
    12061 ccacgacctg acgtccggtg gtctcgtcgg tcgcgcgata caccccgccc ttgaaggcgt
    12121 gccggatcgc cttggcgacc atgtaacggc cgttgaggcg aacggacttc ctccccggtg
    12181 tccgcgtcgg tgtccgcttc cgcggtccgg tcggctcctt ctccttctcc ttctcctgtt
    12241 cctgcgacgg gcccggcgtg gtctccggag aagccgtcgg ctccggggaa gccgccggtt
    12301 ccgggaacgg cggcggcgcc cacgcggggg tggtgaccca ggcctgacgc cggtccttct
    12361 ccagcccgcc gccggggttg cgcagccgta cgtccgtgtc cccgtcgttc gtcgtcgtcc
    12421 gcaccccgcc gaacaccccg tagcggtagt ggacgaggct gcccggggcg tacggccggt
    12481 ccgagaggat gcgggggccg cgcagtccca gcgtcgccgc gtgcagccgc cgggccagcc
    12541 ggcggaacag ctccgggtcg tcggggtaga ccgtgatgaa cttgccgccg ccaccgcgat
    12601 cggcgcgccc gcccgtcagc agggcgaccc ggtccagggc ccccgcgaac ttgaacgagg
    12661 cccgttcctc caccaggacg tcggccgcca ccgccaggac cagggccgcg gacagcggtg
    12721 tggccgacag gtgcagcttc cagccctgct cgccgctccg gtggccgcgc ggccggaccg
    12781 agcaccagaa ctccccctgc tcgaccgtcc attgcgtcgc accgcgccgg tgcagcaccc
    12841 cttcgacgat gccgggcagc aggccggtgt ccagcgcgaa gaagctgccg ccgtcgtgtt
    12901 cgtcgcggtc ggtgctcacg ggcgatcctt ccttgccggt gcggtgaggt ggcaggaccc
    12961 tgacggtccg ggcggagccg gtgcgcggtg cggaagcggc gatgatctga tgtgacgagc
    13021 agtcatatgt gtttcggcca gggcgcatcg aaagatctgc cgagttgtcc gggaatcgcg
    13081 gaccgtcctc ggccacctct gcctatcgtg gccgcgggcg atcccccgat cgccacgggt
    13141 gacgttagcg gtgcgccgag gggccggtgc accacccgtt ctggggggtt gcgatcaagg
    13201 ggggccgtcg gatcgacaga accgaaaccg ggctgcaccg ggcccggaag accatggtca
    13261 tcgccaccgc gctgtatcgc ggcagccacc tggtcgccgg gggcgtcgtg gtcgcgcagc
    13321 accagcgcga ccgcctgttc ccgtggctgg ctctgagtgc cgccatcgcg tccaccgcgc
    13381 tcatctggtt catggcggcc cggcaccggc ggctcgttcc ctgggtcgtg ggactcgacg
    13441 tcctggtgat cggctgcctg ctgcccttcg gcgcgtacgc ctggggcggg gcccgcaccc
    13501 aggagtcggt cgcctgggtc atgctcctgg gcggatcggc ctcggcgatg gccgccgtcg
    13561 ccttcggagc gcgcctcctc gccgtcgccg tggccctgct ggtggcaacc catctcgccg
    13621 ggtacctcat ggtggcggcg gacgccgccg tgaccggcgc ccatctgaac gccctggtct
    13681 tctccgccgt cgtgtcctgg gtgctcacct ggtacctctg ccggcagggc gagcaggtcg
    13741 attcggccaa ccggcgggcg ctggccgcgg aggcgcagcg ggccaggttc gcggagcgcg
    13801 tcgcccatca caacgccctg cacgacaccg tcctcgccac gctgacggcc atcgcccgcg
    13861 gcggcgtcga cgccaacacc tcgatgatgc gcgagcgttg cgcgcgggag gccgcgtacc
    13921 tgagaaggct ggtcgagcag gcggacgacc gtgagccggc ctccgaggtg cgggccgcac
    13981 tcgaagagtc cgtacgcgcc gccgaagcgc tggggctgcg ggtgaccgcc cgctaccacg
    14041 agccgcccgc cgtgcccggc gagatagcgc tggccatggc acgggccacg accgaagccc
    14101 tcaacaacgt acggtgccac gccggtacgg gacacgcctt cctgaccgcc gtcggcgact
    14161 ccggccggct gatcgtcacc gtggtcgacc gaggccgggg tttcgacacc ggatccgccg
    14221 ggccggaagg agcgggcgga cccggcggac cggacgatgc gggcggagcc gccggaccga
    14281 gggcatcggg cggagccgcc ggaccggggg tgtcgggcgg accggagggg ccggtcggtc
    14341 ccgtccggca ggccaccggc gggatcgggc tcgaccgttc cgtgtacgcc cggatgcgcg
    14401 gcgtgggcgg ccgggccttc gtggacagcg cccccggcga gggtgtccgc gtggagctga
    14461 gatggccggg gtgatcaccg tcgccgtggt ggacgacgac cggatgctgc gcgacggcat
    14521 ccggtcgtgg ttcgcgggag tcgaggagct ggacctcgtc gcgtgcgcgg ccaccgtcga
    14581 cgagttgctc gcgggcccct gggcgccgcc ggacgtcgtc ctgctggacc tcatgctccg
    14641 ggacgaccgg ccgcccgccg acaacatccg ccgccttcgg gcggccggca gccgcgtgct
    14701 gatgatcagc gtggtggcgg accgcgaccg gatcgtcgcc gccgtcaccg acggcgccga
    14761 cggcttcctc acgaaggacc acgagctgtc cgtcctcgtc gaagccgtcc gcgagatcgc
    14821 ggccgggcgc accgcccact ccccggagct ggccttcgcc ctggcctacg accggggctc
    14881 gacccgcccc cggctctctc cccaggaacg cgaggtgctg gtggggtacg cctccgggct
    14941 cacgttgaag gcgaccgccc gccgtgccgg gatcacggtg aacacggcga agtactacct
    15001 ggaccgggtg aaggccaagt accaggaggc ggggcggccc acctacacca agatcgacct
    15061 ggcgacccgg gtccgcgagg acggctggcg ttgacccgca ggcgggcggc atccgaggat
    15121 cgctggtgtg agccaccctt ctgacctgcc gccgccctcg cccgagccct cgcccacggg
    15181 cgaaccgccc cgtacggacg gcccgccctc cccctgggcc ccgccgtcgc acccgcccgc
    15241 accggcctgg ccgggcggac cggccgggca ggcatggcag ggcgggcagg gctgggacag
    15301 gcccccggag tggagccgcc cgccttccgg gccggtgcgc gcgcccgccg gctcccgcta
    15361 cgacgagcag gggcgcaacg ggcagggcgg acggttcggc tggctcggcg agctggcggt
    15421 cgtcgtggcg ctggtcgtgg tgggcgtcct ggtcgtcagc atcgccgggt tcgtcgtcgc
    15481 ggaactgctg gacgcggggc ccgaatcggc ggacagcgaa ctcttcttcg aggacccggt
    15541 cgccgatctc gtcgtccagc tcctcggcat cgcgatcggc atccccatcg tcctgctggc
    15601 cgtccggctg ctgggccgcc gccccgccgg aaccgtctcc tccgtggtcg ggcggatccg
    15661 ctggggctgg ctcctgcggt gcgccgccgt ggcgtttccg ctgatgatcg tgcagatcgg
    15721 cctgctgatc gcgtggacct ggaacgacga gccgctcggg gagacgggga ccggattccc
    15781 ggggtggccg gtctttctgc tgagcctggc cgtggtgctg gcgctcgtcc cgttccaggc
    15841 cgctgccgag gagtacgtct tccggggctg gctggtccag gtgatcggcc gggccgtgcg
    15901 gacgccgtgg cccgcgatcg tgatcgcctc cctgctgttc gccctggccc acgggttcgg
    15961 tgaactctcc ggcttcctcc tgctgttgta ctcggcgctg tggtggggct ggctggtgat
    16021 ccgtaccggc ggcctcgaag ccgtgatcgt catgcacgtc gcgaacaacc tgctggcctt
    16081 cggcctggcc gccggtttcg gtgagctggc cagtacggag accgcggccg acgcgccctg
    16141 gcaggccatg gtggtcgagc tggtcttcgc cccgctgtac tgcctgacca tggcccggat
    16201 cgcggaccgc cgcggggtcg agcgggtgag cccttgaggg gccggggtcg gggccggccg
    16261 ggacgggagg atctgtgaag cgtacgaggc tgtggaagtc cttcgtcccg gtggtggtga
    16321 acctgttgct cgggattccg gccgtggtgc cggtcttcct gatctggtac gtcctgtcca
    16381 acgggcccct ggcggagctg gggtggaccc agcgggaacc gaccgagaac gacgggatgt
    16441 ggctgtggct ggtcatcgtc gtcccggtgg tggcctgctt cggaggcctg tggaccctgc
    16501 tcaacctgtg gatgcggcgc cggctgatcg ctgcggcgtc cccgtacccg tactggtcgc
    16561 tggcggtgac gctgaccctc gccccgttcc tcctgggcgc cgccttcggc tgagcagcgc
    16621 ggcggtgcag gccagggcgg cggcgagacc ggccgccgta cggaggagca cgttgaccga
    16681 cgggggaagg tgctccaccg ccgaaccgtc ggagtagagg caggcgttgc gcaggggcca
    16741 gaactcctgg tgcaggccgg ccagcggggc gccggacctg ttcacgtcct cgcacagtgc
    16801 ggggaacggc ccgcccaggg tgacggagaa ccagccgcag cagtacccgg ccgtggccgc
    16861 gaagccgcag agcagggcga ggactccgaa gatcctggcc ggcgagcggg gcgggttctt
    16921 cagcaggagg acgagcacca ggacgcaggc ggccccggcc accgcgctga tcagcagaaa
    16981 caggcccatc agtggtgtcg gcacggcccc atcctctcgc ggccgggtcg gagccggccg
    17041 gagggggccg gggagggccg gggagggccg gggaggggcc ggggatgggc agccgggtcg
    17101 cggagatcag gcgggtcgga acggcacggt cagctgcgcc tggacgtgcg cccgcagcac
    17161 gcccgccatg tccgtcgtgc agtcgctgat cagccactgg atctggaggc cgtccatcag
    17221 cgcgatgagc tgctgcgcgg ccgccgacgg atcgacgtcg tcccggagtt cgcccgcctg
    17281 ccgggcctgg aggtaggcgc gttcggtgtt ggcgacggac gtacggtagc gggcctcgaa
    17341 gtacgcgtgg gccgggtggt cgggggcggt ggcctccgcc gcgaccaccg agaacagctc
    17401 gacgatcccg cgccgcttgg cgttcagctc cgcgaggtcg gtcagccggc gcagatggtc
    17461 gatgccccgc gtcacgccca gcgacagcca ctcgtcgtcc acgtcgtcgc ggcgctggag
    17521 cacggccagg agcagggctt ccttcgtcgg gaagtggtgc aggagccccg ggtgggagat
    17581 gccgcagcgg gtggcgatga cgcgcagcga agcgccccgg tagccggcct cgccgaactg
    17641 ggccatcgcc tggtcgagga tctcggtccg cttggcccgg cccttggcgt agccgcgccg
    17701 ggtttccggg gtcacgcgta ttcacccgtt gtcatcggac gcctttctcg ttccgcccca
    17761 gattctcaca ggggcgaata cttaccaagc ggtcgggatt gagcgtacgg tactgcggag
    17821 tgccgtcatg gctgtcgtgg ccgtcgtgag aggaagtcct gtgggtctca agccgccgta
    17881 tctcgacccc gagctgcccg tcggggagcg ggtcgccgac ctcctggggc gcatgacgct
    17941 gcccgagaag gtcggccaga tgctccagct caacgcgaag gagggggtgc ggcacctcgt
    18001 cgaggacctg cacgccggct cgatcctgca cgcctcgccg gaccgggtgc gcgaggccgc
    18061 cgcgctcacc gcgaagaccc ggctgcgcat tccgctgctc gtcgccgagg actgcatcca
    18121 cggacactcc ttctgggagg gcgccacgat ctacccgacg cagctcggga tggccgccac
    18181 ctgggacccg gagctggtcg agcggatcgc gcgggcgacg gcggtcgagg tcgcggcgac
    18241 cggagtgcac tggacgttct cgccggtgct ctgcatcacc cgggacctgc gctggggccg
    18301 ggtgagcgag accttcggcg aggacccgct cctgatcggc gagctggcct ccgcgatggt
    18361 gcgcggctac cagggcgacg gcctcgacga cccgaccgcg atcctggcct gcgccaagca
    18421 cttcgccggg tactccgaga cccagggcgg ccgggacgcc agcgaggcgg acatctcacg
    18481 gcgcaagctg cgctcctggt tcctgccgcc gttcgagcgg gtcgccaagg agggctgccg
    18541 tacgttcatg ctcggctacc agtcgatgga cggcgtgccg atcacggtga acaactggct
    18601 gctcaacgag gtgctgcgcg gcgagtgggg atacaccggg acgctggtca ccgactggga
    18661 caacgtcggc cgcatggtgt gggagcagaa ggtctacgcc gactacgcgc aggcctcggc
    18721 ggcggcggtc cgggcgggca acgacatggt gatgaccacg tcgaacttct tcgagggggc
    18781 ccaggaggcc gtcgcccagg gcgagttggg cgagacggag atcgacgccg ccgtacgccg
    18841 catcctgacg ctcaagttcg agctgggcct cttcgagaac ccgcgccacc ccgacgccga
    18901 ccgccaggcc gcgttcatcg gcagcgccgc gcacgccgag ctgaacctgg aggcggcccg
    18961 ccgctcgctg gtcctgctga cgaacgacgg cacgctgccg ttcgcgggcg gcctggcggc
    19021 cggaggggag gggcgggcca gcgggcccgg tccccgtacg gtggcggtca tcggccccaa
    19081 cgccgatgac gcgcagaccc agttgggcga ctgggcgggc tcctccgggc aggccgactg
    19141 gctgccggag ggccagccgc gcgccatgat ccgtacggtc ctcgacggct tccgcgacca
    19201 ggtgcccgcc gactggaccg tctcgtacgc gcccggcgcc cggatcctgg atgtcgggcc
    19261 ggacccggag ggggagttct tcccggacgg ccagccgcgc ccggaagtcg tccacccggc
    19321 cgcccccgac gcggagttga tcgccgaggc cgtggccgcc gccgaggccg ccgaccatgt
    19381 ggtggccgtc gtcggcgacc ggatcgagct gatcggcgag ggcaagtcga cggccacgct
    19441 cgaactcgtc ggcgaccagg tcgcgttgct ggacgcgctg gccgcgacgg ggaagccgct
    19501 cgtcgtggtg gtcatcagct ccaagccgct ggtgctgccg ccgtccgcgc tcggtgcggc
    19561 ggcgatcgtc tacgcggcca acccgggcat gctcggcggt caggccgtcg ccgaactgct
    19621 cctcgggctg atcgagccga ccggccggct gccgctgtcc ttcgcccggc acgcgggcca
    19681 gcagccgacg tactacaacc aggtgcgcgg ccagcacggt acgcgctacg cggacctcac
    19741 ccagcgcccg gcgttcgcgt tcggcgaggg gctgagctac acgacggtcg actacaccgg
    19801 tctggaggtg ctgacggcgg tggtcgacga gtcggagacc gtacgggccc gggtcacggt
    19861 gaccaacacc ggtgcgcggc ccgcgctgga gacggtgcag gtgtacgtga gcgacacggt
    19921 gacctcggtg acctgggcgg agaaggagct gaaggcctac cgccaggtgg agctggcccc
    19981 cgggcagtcg cgcgaggtcc tcttcgagct cccggccgcc gactgcacgc tcgtggacgc
    20041 ggcgggccgc cgcatcgtgg agccgggccg cttcgagctg ctggtgggcc cgtcgtcccg
    20101 cgacgaggcg ctgctgcggg gggagttcac ggtcaagggc tgagccccgg accgtgacgg
    20161 ccgagccgcc gatgggaccg ccccgcgcct gaccgcggga gcggtcccat cggtgatgtc
    20221 cccgtagccg gcggacgtcg gcggatgtca gcggacctcg aagaagtcca cgttgtgccg
    20281 gttgaccttg atgccgagct tgacgaagcc gcccttgccg tcctcgcccg cgtacttgcc
    20341 ccagtactgg cagtggaagc cggtctcggt ctcctcgtcc acggccttgg ccgcgggcag
    20401 ctcctcgcag gagagcttgc tgatgtcgga acggcccttg ttggcggtcc agagccggtc
    20461 gtaggcgttc ttggcgacca gcaggccctt cttcggggtg ctgttgtaga aggtcaggaa
    20521 gctgcccggc ttgtacttct cgctgatctc gatctcgtac gggacggtcg cgccctcgta
    20581 cgtcacgttg cagatgctga cggcactggc cttctgggtc accccgtccg ggcagttcgc
    20641 gctggtcttc cccggcacct tgaggcggcc gagcaggtct tcctggagct tgtgctcgac
    20701 cttctcggtg aacgacgcgc cgttggcggg cttcggggtc accttgagct tggggtcgga
    20761 gctggacgcg aggacgtccg gctgcggccc ggtcaccggg accgcgaggt ccgcgcccgg
    20821 ctcgggagcc ttggcctcct cgctgggggc ctggccggcg gagccggacg atccggccga
    20881 tccggaggag ccggcggagt cgtcgctcga cgaggagccg caaccggccg ccagaatgcc
    20941 gacggcggcc agcccgatga ggttcttgga gatacgcata aagggagcct aagttgcgcc
    21001 tgtgacaacc ctgtgtggct gatggggccg ccgagggccc tgatcggtgc ggccaaaagg
    21061 tacgtgaggc gtgagaacgg ggcgttccgg tttgcgaacc gtacgttctg tgacgttgat
    21121 ggtggctcag tcgagaagga cccgtggccc gactgtgacg gtcggcccgg tgaccggggc
    21181 cgggaccggg gcggtggttg gggcccggac cggggaggtg gccgggggcg gcggcgcggc
    21241 cggttccggg atctgccccg cggtcggctc cgcggccggc tccggggcgg accggcgggc
    21301 gtcgtcgccg aagacccggc gggccaggtc ctcgcggagc cggacgagcc gggcgatctc
    21361 ggcgtcgagg gcggcgagcc ggcggccgac gacaccggac ccggaaccct ccggagcgtc
    21421 ggcggcgccg caccgcggtg gcgggtcctc ggtgaggaga tggaggcggt cggcgcagga
    21481 gcgcaggtcc tcgatggtga acccggagcc caggagctcg cggatgacgc ggagcagggc
    21541 gacctcggcg ggccggtagt cgcgctggcc cgaggcggtg cggccgggcg gcgggagcag
    21601 tccgcgttcc tcgtacagcc gcagcgctct gggggtgcag cccgccgccg ctgccgcctc
    21661 accgatccgc atggacgcct ccgcgttcgc cgtgccccgg ccggtcctca gggcaactcc
    21721 accaccacgg cgccgaagtg ccggcccccg atcaactcct gcaacgcctg cggagcgcga
    21781 tcgatgcccg ggatccgggt gtgggggaag acgatctcgc cggaacgcag ccactgcccg
    21841 aaccgcccgg tccactcctg ctcgacgtcg ggatggtccg cgccgctgta gccgcgcagc
    21901 gagacgcccc gggtgatgac ccggaaggaa tcgatctcca ccggtgcgct gccgcccgcc
    21961 cgtcgcgccg acagctgtcc ggacagcgct ccgaccaggg cgaagcgggc gccctggcgg
    22021 gccgcgtgga cggccgccgc gagctgctcg ccgccgacgt tgtcgagcag gacgtcgatg
    22081 ccctcgggcg cggcggcggc gagctgggcg gcgaacgggg tgtcggtgcc gggcaggagg
    22141 acggcgtcgt aaccgagttc ggcgaccagc cgctcggcct ttccggcgga ccgggtgctg
    22201 ccgatcaccc gccccgcgcc cagcagccgg gcgatctggc ccgcgagcgt gcccacggcc
    22261 ccggccgcgc cggtgaccag gacggtgtca ccggcacgga caccggccag gcgggtcagg
    22321 gccccgtagg cggacgagcc ctgggccagg tgggcgacgg ggtccggcag gacgtcccgg
    22381 acgggcgcgc agtgggcggc gtccaccacg gcgtggtccc gccacccctg gaggtgggtg
    22441 acgatgtcgc ccggccgcag cgggccgccc tcggccgccg cgaccacctc gccgacggcg
    22501 gggccgaaca gggtgtcgcc gctgcgcagg gcggggagcg gcactccgtc gacctcgccg
    22561 ccgatcaggg tgcgcagccc cgggaagacg aggaaggcac ggttgcggac gagcacctgg
    22621 cccgcgccgg gcgcgggcag cggtgcttcg acgacggcga agttctccgg ggcgggcagc
    22681 ccttcgggca cggaggtcag ccggacctcg cgtgcggtac ggggcgggtg cgggacggcg
    22741 ggcatggcgg gctcctcggc tccggccctg acagggccgg ggtttcggcg gctggggtgc
    22801 ggtgacgctc acccctgccc cgcacgtcag ggtcaagccg aagggccgcc gccggagctc
    22861 ccggtggagc gcgtcagctt gtacaggtcc caggagtccg ggtcgccgat gtactggta
//
