LOCUS       NZ_CP079114            22214 bp    DNA     linear   CON 06-SEP-2024
DEFINITION  Streptomyces sp. WY228 chromosome.
ACCESSION   NZ_CP079114
VERSION     NZ_CP079114.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WY228
  ORGANISM  Streptomyces sp. WY228
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Volatile organic compounds produced by endophyte Streptomyces sp.
            WY228 mediate plant growth and salt stress tolerance by activating
            hormonal signaling and anthocyanin biosynthesis,
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8286721)
  AUTHORS   Qin,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JUL-2021) Key lab of biotechnology of medicinal
            plants, Jiangsu Normal University, No. 101 Shanghai Road, Xuzhou
            221116, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.5
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019287315.1-RS_2024_09_06
            Annotation Date                   :: 09/06/2024 06:02:41
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,303
            CDSs (total)                      :: 7,213
            Genes (coding)                    :: 7,059
            CDSs (with protein)               :: 7,059
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 155
            CDSs (without protein)            :: 154
            Pseudo Genes (ambiguous residues) :: 0 of 155
            Pseudo Genes (frameshifted)       :: 83 of 155
            Pseudo Genes (incomplete)         :: 99 of 155
            Pseudo Genes (internal stop)      :: 10 of 155
            Pseudo Genes (multiple problems)  :: 36 of 155
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:35:29
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 183666
            Orig. end                         :: 205880
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP079114.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22214
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22214
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22214
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12214](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12214
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(55..837)
                     /locus_tag="KV381_RS00830"
                     /old_locus_tag="KV381_00830"
     CDS             complement(55..837)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060700.1"
                     /locus_tag="KV381_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00830"
                     /product="DUF4389 domain-containing protein"
                     /protein_id="WP_218784249.1"
                     /transl_table=11
                     /translation="MAEGQWSPGRKEMDADEFRPVLDIVEPARQRRLTVLLRLLLLIPH
                     FIVLFFLHIAAFFTVIVGWFAALVLGRLPDPVFRFLAGVLGYDMRVSASDMLLIDRYPP
                     FALTPPADYPARIEVRPTPLNRLAVLFRVFLMIPAAIVQSLAVYGWWALAFVWWLITLC
                     LGRMPRPLFEATAATLRYRMRFSAYVMMLTPAYPKGLFGDDGDLAVAREPARSATRPLV
                     LSSAAKWLVVLFLVLGLAGNITTSVTTSTTDDTRLVGR"
     gene            complement(950..1687)
                     /locus_tag="KV381_RS00835"
                     /old_locus_tag="KV381_00835"
     CDS             complement(950..1687)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458443.1"
                     /locus_tag="KV381_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00835"
                     /product="VanZ family protein"
                     /protein_id="WP_030086522.1"
                     /transl_table=11
                     /translation="MVVRGAVLTVVLLGLVVFSVLLAKVTLTPSPASEDLVTSNLRPGR
                     SLRQYAEDYTFLAACKQAGGNLLLGVPFGLLLPFFVPRRLRMIRMTLLTAVAMAVVELI
                     QGALVAGRAFDIDDVILNTAGALLGYFVLGRRITHRYYMYADVPAPSERPAEPEPAPEP
                     KRTPRLTAGAKAARTKPPGAKAAGAKAARTKPAGAKGTRTKSAGKKGTATKPAGTKTAA
                     TKGTSTKKPRSLLDRVRTRVRSR"
     gene            1835..2335
                     /locus_tag="KV381_RS00840"
                     /old_locus_tag="KV381_00840"
     CDS             1835..2335
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971171.1"
                     /locus_tag="KV381_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00840"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_030086520.1"
                     /transl_table=11
                     /translation="MSARTKKDLLDEADRLRTGGRPEEARERLLALTAEYPDDAEVAYR
                     TAWIHDVLGLESEAVPYYERALANPELAEEDRRGALLGLGSTYRVLGRYGQAVETLRRG
                     VEEFPDHGALRAFLAMALFNTDEHHEAMRLLLELTATTSQDPSVQEYRRAIEHYAKDLH
                     ETV"
     gene            2499..3182
                     /locus_tag="KV381_RS00845"
                     /old_locus_tag="KV381_00845"
     CDS             2499..3182
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382263.1"
                     /locus_tag="KV381_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00845"
                     /product="YoaK family protein"
                     /protein_id="WP_030086518.1"
                     /transl_table=11
                     /translation="MPWRGEGALLLLSAASGAADAFVFLCVGQVFAGVMTGNLVLLGAS
                     AAGAGERGVALKVAVALGAYFCGAAAGALMAGRLGLRVPVLLGAEVVLLGAAAVLWGLE
                     LVSSYGDRLGLLALVAVAMGVQGRVRVTPTNYFTGTLTSLAGRVALRELRGGDGWVLGR
                     LAAVVAGAAVAALAERWWSPGAALGALVPAAGALVLETAPLRGGGPRPDRGKPRPDRGN
                     PAGAA"
     gene            complement(3407..3667)
                     /locus_tag="KV381_RS00850"
                     /old_locus_tag="KV381_00850"
     CDS             complement(3407..3667)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015606682.1"
                     /locus_tag="KV381_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00850"
                     /product="type B 50S ribosomal protein L31"
                     /protein_id="WP_030086515.1"
                     /transl_table=11
                     /translation="MKPRIHPVSRPVVFRDRAADVAFLTRSTADSGERVQWQDGNTYPV
                     IDVETSSASHPFYTGGRQVVDTAGRVEQFRRRYGTGETSGS"
     gene            complement(3744..3908)
                     /gene="rpmG"
                     /locus_tag="KV381_RS00855"
                     /old_locus_tag="KV381_00855"
     CDS             complement(3744..3908)
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009192346.1"
                     /locus_tag="KV381_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00855"
                     /product="50S ribosomal protein L33"
                     /protein_id="WP_030086513.1"
                     /transl_table=11
                     /translation="MARSEIRPVVTLRSTAGTGRSYVTRKNRRNTPDRLELRKFDSAAG
                     RHVLFRETR"
     misc_feature    3953..3968
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.65"
                     /tool="antismash"
     misc_feature    3955..3969
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.29"
                     /tool="antismash"
     misc_feature    complement(3957..3968)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.7"
                     /tool="antismash"
     misc_feature    complement(4025..4040)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.71"
                     /tool="antismash"
     misc_feature    4051..4066
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.14"
                     /tool="antismash"
     misc_feature    4063..4076
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.26"
                     /tool="antismash"
     gene            4220..5650
                     /locus_tag="KV381_RS00860"
                     /old_locus_tag="KV381_00860"
     CDS             4220..5650
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006470 - protein dephosphorylation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956434.1"
                     /locus_tag="KV381_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00860"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_030629881.1"
                     /transl_table=11
                     /translation="MPSPLFADRPAPQPPAHDAVDDLIHRTRRLRGDVDAVRRDAALFD
                     EDDPQLRWQRALCELAVHHLDNLDEHLGQLRAGLPGPRTEDSAPRDDEAPAGPGAGSPP
                     NRVGSAEWNLLTDESSWSDELYEIFGRPPGSTPLSLDDLPSVLLPEDQPLLTAMVTGCL
                     VDGRPMDGEFRIVRPDGDTRTLHMTGEPVLDAEGCTASMWAVLRDVSELRRSEQAVGRS
                     RASVRREKHIQRTEHRMAVELQETVLPPWRGSLRLPARGPGALDIAAHYLPSASSGLIG
                     GDWYDAMELPDGRTLLTVGDLTGHGIPATSAMAMMLGALRGMAVAGIEPGALLGHLNQV
                     LETSVQPALGSALCCRFDPGTSLLSWAQAGHPAPLLFRDGSGRLLPPPDGMLLGAASNV
                     VFEQDDVRLLPGDVLVLHTDGLTRRGDRGAGPEALLALAPRFAEARTAQECVRSVVEEF
                     GGTERPDDACVLVARIGA"
     gene            complement(5781..7268)
                     /locus_tag="KV381_RS00865"
                     /old_locus_tag="KV381_00865"
     CDS             complement(5781..7268)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007458453.1"
                     /locus_tag="KV381_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00865"
                     /product="hypothetical protein"
                     /protein_id="WP_030086509.1"
                     /transl_table=11
                     /translation="MTGEPNTRLSDLFGLAGWSKGELARMVNRQAAAMGHPQLATDTSR
                     VRRWIDMGESPRDPVPEVLAALFTERLGRVVTIEDLGFGRRGRVGKRRDSGTENNPDQL
                     PWAPERTAAVLTEFTGMDLMLNRRGLVGAGAALAAGSTIAGPMYDWLHSDPALAADAPR
                     TSDPLHADPAGFDRYEAAPVGSEEIEALEHSVEVFRAWDASRGGGLQRKAVVGQLNEVG
                     GMLAYRHPDHLQRRLWGVAANLAVLAGWMSHDVGLEPTAQKYFVIAAHAAREGGDRPRA
                     GEALSRAARQMVHLGRPDDALDLMKLAKSGSGDETLPRTQAMLRTIEAWAQASMGRGQA
                     MRRTLGEAEELFVSDKGDVPPPSWMQMFDEADMHGMQALAFRTLAEHDPGAAIIAQRHA
                     KQALELRINGRQRSKIFDYISLASACFIANDPEQADRYARLALVSMGETSSHRTWDRLR
                     EMYRLTGQFAGYAGIQDLREEIELSLPNQKKAKGTQI"
     gene            7500..8636
                     /locus_tag="KV381_RS00870"
                     /old_locus_tag="KV381_00870"
     CDS             7500..8636
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060711.1"
                     /locus_tag="KV381_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00870"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_086778366.1"
                     /sec_met_domain="APH (E-value: 7.5e-17, bitscore: 60.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTASSSVSAPPRPLRPMGAGGGPYLAPHAGAPAQGPGRARRAAG
                     PGAGPLSGRIDLSGPQGAQVRMAIASVQRICPEFNPVQVLRRSGRSVLIVGATGRATAV
                     AKCLLDHSPAWTERFRHEIAAYRAFVRHRPPVRVPRLIAADPENCTLVIERMPGRVAAL
                     TRHPAEAPPRADIRAALGAIARVNAWRPPPGLFEAPLDYASRIARYHELGLFTDRDLGD
                     LQKLLHGLAHAGGRQGMGQFCHGDALLSNILLSPTGPVLVDWEHAGWYLPGYDLATLWA
                     VLGDAPVARRQISQLAQARGPAARDAFLVNLMLVLTREIRNYETAVQRTMREAPPVGAG
                     QDRPGALSSGEEQRLLLRRLHDDCAMARRAVRAAVGTR"
     misc_feature    7821..7823
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9181..9849
                     /locus_tag="KV381_RS00875"
                     /old_locus_tag="KV381_00875"
     CDS             9181..9849
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971163.1"
                     /locus_tag="KV381_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00875"
                     /product="transglycosylase SLT domain-containing protein"
                     /protein_id="WP_030086507.1"
                     /transl_table=11
                     /translation="MPRISTLRITRSHKIATAVLVAAGSVTAIAATGGASEAQTPQARS
                     SISVEPVAAAGIPTAKDAAAKKAAEATAAKEAAAKKAAAKAAAEKDATEARSEKQAANR
                     STERKAVTPKKFANNLDGWIRESLDIMKKKNIPGSYEGLHRNIMRESSGNPNAVNDWDI
                     NARNGIPSKGLLQVIQPTFDAYHVKGTPKKLTDPVANITAAANYAADRYGSIDNVDSAY
                     "
     misc_feature    complement(9885..9899)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.69"
                     /tool="antismash"
     gene            10001..12214
                     /locus_tag="KV381_RS00880"
                     /old_locus_tag="KV381_00880"
     CDS             10001..12214
                     /EC_number="4.2.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382258.1"
                     /locus_tag="KV381_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00880"
                     /product="terpene synthase family protein"
                     /protein_id="WP_030629878.1"
                     /sec_met_domain="T1TS (E-value: 1.6e-84, bitscore: 283.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQPFSLPDFYVPYPARLNPHVEAARTHTRAWARSMGMLEGSGIW
                     EEKDLEAHDYALLCAYTHPDCSAEALSLVTDWYVWVFFFDDHFLELFKRTPDREGGKRY
                     LDRLPAFMPMERGAPTPEPENPVEAGLADLWARTVPAMTDAWRARFAESTENLLNESLW
                     ELANIHEGRIANPVEYIEMRRKVGGAPWSAGLVEYAANAEVPASVAGSRPLRVLRDAFS
                     DAVHLRNDLFSYQREVEDEGENSNGVLVLEKFLDCSTQEAADAVNDLLTSRLQQFENTA
                     LTELGPLCAEKGLDPTETAAVLAYVKGLQDWQSGGHEWHMRSSRYMNGGGAGEAVAGFG
                     MSAASIKLTLRSETARARSHSHVPYQHVGPSLLPDFDLPFGTTLSPHLEGARVRLVEWA
                     RRMGILEAQPGVPGSHIWDERRIVAIDLPLCAAGLHPDATPDELDLSSGWLAWGTYGDD
                     WFPVVHGRARDLTGARLANERLSLFMPLDGEGTPEPVNALERSLADLWRRTAAPMDLSA
                     RRTFRTSIESMTESWLWELANQAQNRIPDPVDYVEMRRATFGSDLTMSLCRLGHGRTVP
                     DEVYRSGPMRSLENAAADYACLLNDLFSYQKEIEYEGEVHNGVLVVQNFFGVDYPTGVA
                     IVHDLMNSRLRQFLHVAEVEFPVLYDDFDLGAEAREILAGYVQELKHWIAGILIWHRGC
                     RRYREEDLRQGHDTPWHLSGPTGLGTSAAQVTRLMAQLAGSAV"
     gene            complement(12314..12814)
                     /locus_tag="KV381_RS00885"
                     /old_locus_tag="KV381_00885"
     CDS             complement(12314..12814)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550733.1"
                     /locus_tag="KV381_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00885"
                     /product="hypothetical protein"
                     /protein_id="WP_003971159.1"
                     /transl_table=11
                     /translation="MSFLRRRSAATPAGPDFDVLAMDPGDWPGNLGAGLLPAPDGSCQG
                     VFLRYDLYGGRGPAMIIGNLPEGSPARETEEGQVPFEVAQLLLALENDEPIEVVSSEDV
                     PVMQGDNLLIVRRVKLSESRIACVQFDRSDGVLVTIASWDRPITDDLYTLLKPLPAELF
                     QQG"
     misc_feature    12818..12828
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.79"
                     /tool="antismash"
     gene            complement(12892..14058)
                     /locus_tag="KV381_RS00890"
                     /old_locus_tag="KV381_00890"
     CDS             complement(12892..14058)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971158.1"
                     /locus_tag="KV381_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00890"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_218784250.1"
                     /transl_table=11
                     /translation="MPKEPVAVVGIGQTKHVAARHDVSIAGLVREAAVRALADAGLTWS
                     DIDAVVIGKAPDFFEGVMMPELYLADALGAVGKPMLRVHTAGSVGGSTALVAANLVAAR
                     VHRTVLTLAFEKQSESNAMWGLSLPVPFQQPLLAGAGGFFAPHVRAYMRRTGAPDEVGS
                     LVAYKDRRNALKNPYAHLHDHDITLEKVRAAPMLWDPIRYSETCPSSDGACAMILTGRE
                     GAARAPHPPAWVHGGAMRSEPTLFAGKDFVSPQAGKDCAADVYRQARITDPRREIDAVE
                     MYVPFSWYEPMWLENLGFADEGEGWKLTEAGVTELDGDLPVNPSGGVLSTNPIGASGMI
                     RFAEAALQVRGRAGEHQIDGATRALGHAYGGGAQFFAMWLVGSEPPPG"
     gene            complement(14051..15103)
                     /locus_tag="KV381_RS00895"
                     /old_locus_tag="KV381_00895"
     CDS             complement(14051..15103)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018550730.1"
                     /locus_tag="KV381_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00895"
                     /product="thiolase domain-containing protein"
                     /protein_id="WP_193464008.1"
                     /transl_table=11
                     /translation="MRDVAIVAFAQSAHRRRTDELSEVDLLMPVLHEVLGATGLKANEI
                     GFTCSGSADYLAGRAFSFTMALDGVGAHPPISESHVEMDGAWALYEAWVKIQTGEADTA
                     LVYSYGKSSPGRVRDVLTRQLDPYYLAPLWPDSVALAALQAQALIDAGDTDEPALAEVA
                     ARNRTAAVGNPYAQLTGDVPVGDHLVRPLRTADCPPIGDGAAAVVLAAGDTARELCERP
                     AWIRGIDHRIEAHGLGVRDLTDSPSARLAAQHAGAFERPVDTAELHAPFTSQEVVLRKA
                     LGLGDDVRVNPSGGALAANPVMAAGLIRLGEAAARIHRGESDRALAHATSGPCLQQNLV
                     AVLEGESAHA"
     gene            complement(15104..16060)
                     /locus_tag="KV381_RS00900"
                     /old_locus_tag="KV381_00900"
     CDS             complement(15104..16060)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382254.1"
                     /locus_tag="KV381_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00900"
                     /product="Zn-ribbon domain-containing OB-fold protein"
                     /protein_id="WP_218784251.1"
                     /transl_table=11
                     /translation="MTDVLSAPLVVEFPFTRSLGPVQSAFLTGLRERTVLGVRTEDGTV
                     LVPPVEYDPVTANEIRDLVEVAPTGTVTTWAWNPAPRRDQPLDTPFAWVLVRLDGAGTA
                     LLHVLDAPGPDAVRTGMRVRIRWAATRTGAITDIACFEPYEGEPDGSEPAPHTAEFADP
                     VTGIVTPARLDYVHTPGRAQSAYIKALEERRTVGERCPSCRKVYVPPRGACPTCGVATA
                     EQVEVGPRGTVTTFCIVNIKAAHTANLDIEVPYVYAHIALDGADLALHGRIAGIPYDQV
                     RMGLRVEPVWSEGARHVDHYRPTGEPDADYDTYKELV"
     gene            complement(16076..16876)
                     /locus_tag="KV381_RS00905"
                     /old_locus_tag="KV381_00905"
     CDS             complement(16076..16876)
                     /NRPS_PKS="Domain: ECH (9-258). E-value: 6e-54. Score:
                     174.9. Matches aSDomain:
                     nrpspksdomains_KV381_RS00905_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956444.1"
                     /locus_tag="KV381_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00905"
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_218784252.1"
                     /transl_table=11
                     /translation="MGGTEHLTVRREGATLVLTLNRPQARNALSLPMLVGLHDGWIEAD
                     EDDAIRSVVLTGAGGAFCAGMDLKALAGGGMAGEEYRERMTADPDLHWKAMLRHHRPRK
                     PVIAAVEGPCVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTH
                     ALEMLLTGRSYTAEEAAAIGLVGRVVPDGTALEEALAVAERVNACGPLAVEAVKASVYE
                     GAELTETEALAAELKRGWPVFATEDAKEGARAFAEKRPPVYRRA"
     aSDomain        complement(16103..16849)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KV381_RS00905_ECH.1"
                     /evalue="6.00E-54"
                     /label="KV381_RS00905_ECH.1"
                     /locus_tag="KV381_RS00905"
                     /protein_end="258"
                     /protein_start="9"
                     /score="174.9"
                     /tool="antismash"
                     /translation="RREGATLVLTLNRPQARNALSLPMLVGLHDGWIEADEDDAIRSVV
                     LTGAGGAFCAGMDLKALAGGGMAGEEYRERMTADPDLHWKAMLRHHRPRKPVIAAVEGP
                     CVAGGTEILQGTDIRIAGAGATFGLFEVRRGLFPIGGSTVRLPRQIPRTHALEMLLTGR
                     SYTAEEAAAIGLVGRVVPDGTALEEALAVAERVNACGPLAVEAVKASVYEGAELTETEA
                     LAAELKRGWPVFATEDAKEGARAFAEK"
     misc_feature    16930..16945
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.75"
                     /tool="antismash"
     misc_feature    16931..16947
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    16935..16949
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.75"
                     /tool="antismash"
     gene            17043..18665
                     /locus_tag="KV381_RS00910"
                     /old_locus_tag="KV381_00910"
     CDS             17043..18665
                     /NRPS_PKS="Domain: AMP-binding (8-438). E-value: 2.3e-66.
                     Score: 216.0. Matches aSDomain:
                     nrpspksdomains_KV381_RS00910_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012382252.1"
                     /locus_tag="KV381_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00910"
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_218784253.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-68, bitscore:
                     230.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYNLADLFESVADTVPDREALLYVDHPGTGAERRLTYAELDAAA
                     NRIAHHLIDAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYR
                     DADLAALVFDGEFDERVAAAAPQAPGLRHLIRVGPAGAAPPAGPVVPFAEAEDSGAAGR
                     GFAARSADDQLIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKAPQELAERVAA
                     GGDGITFFPTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPDEVLRTIEKEKVTSVSLVG
                     DAMLRPLIDCLKGPQRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSES
                     GFNGTATADSGPEKGFRVQVNARTAVVDPVTYEPVAPGEPGRIAQRGHVPLGYYNDPAK
                     TADTFFRRGEERWVLLGDMATVDADGIVTVLGRGSQCINTGGEKVYPEEVEQALKSHPD
                     VYDALVAGVPDERWGNRVAAVVQLRDGADALTLDSVQTHCRTRLAGYKIPRALVLADRI
                     QRSPSGKADYRWAKTVAAEAARS"
     aSDomain        17067..18356
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KV381_RS00910_AMP-binding.1"
                     /evalue="2.30E-66"
                     /label="KV381_RS00910_AMP-binding.1"
                     /locus_tag="KV381_RS00910"
                     /protein_end="438"
                     /protein_start="8"
                     /score="216.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FESVADTVPDREALLYVDHPGTGAERRLTYAELDAAANRIAHHLI
                     DAGIRPGEHLGLHLYNGVEYLQTVLGALKARIVPVNVNYRYVEEELVYLYRDADLAALV
                     FDGEFDERVAAAAPQAPGLRHLIRVGPAGAAPPAGPVVPFAEAEDSGAAGRGFAARSAD
                     DQLIIYTGGTTGMPKGVMWRQEDLFFSGLGGGAPTGEPVKAPQELAERVAAGGDGITFF
                     PTPPLMHGTSTLTAFIGFNFGQRVVVHRKFVPDEVLRTIEKEKVTSVSLVGDAMLRPLI
                     DCLKGPQRGTDCSSLFSVSSSGAIMSDSVRAEFQALVPTVMLLNNFGSSESGFNGTATA
                     DSGPEKGFRVQVNARTAVVDPVTYEPVAPGEPGRIAQRGHVPLGYYNDPAKTADTFFRR
                     GEERWVLLGDMATVDADGIVTVLGRGSQCIN"
     CDS_motif       17565..17612
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KV381_RS00910_0001"
                     /evalue="5.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="KV381_RS00910"
                     /protein_end="190"
                     /protein_start="174"
                     /score="18.9"
                     /tool="antismash"
                     /translation="IIYTGGTTGMPKGVMW"
     CDS_motif       18207..18254
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KV381_RS00910_0002"
                     /evalue="3.70E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="KV381_RS00910"
                     /protein_end="404"
                     /protein_start="388"
                     /score="13.0"
                     /tool="antismash"
                     /translation="VPLGYYNDPAKTADTF"
     gene            complement(18854..19849)
                     /locus_tag="KV381_RS00915"
                     /old_locus_tag="KV381_00915"
     CDS             complement(18854..19849)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003971138.1"
                     /locus_tag="KV381_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00915"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_218784254.1"
                     /transl_table=11
                     /translation="MLTEGRFRTDALPRSDRFARWQQCMTDVVAPMEITSPHADDFWAD
                     HRLLRVEDTLLWPTCLHASRYRRTPRLIRQSDPGLLHMTLVLPGSGTVLVDQGGLRSAV
                     GPYDLYVLDVSRPSDVGTVDEPIVGVGVDFPRSLLPLPTSTSLDELLGRPLSGRHGFGA
                     LFSQFVTHLVDQSDSYGPADGPRLNRVLLDLAAGLLAGGLDRETALSPETRTRNLVLTI
                     RTFIGRNLHDPRLTPAAVAAAHHISTRHLHRLFQQEGTTVAALIRSRRLERARRDLADP
                     ALAHTPLHTIAARCGFGAPAHFSRVFRAAHGMSPSDYRHAGLRDRAEPAR"
     gene            complement(19843..21393)
                     /locus_tag="KV381_RS00920"
                     /old_locus_tag="KV381_00920"
     CDS             complement(19843..21393)
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-267). E-value:
                     3.1e-26. Score: 84.4. Matches aSDomain:
                     nrpspksdomains_KV381_RS00920_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018956456.1"
                     /locus_tag="KV381_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KV381_00920"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_086777879.1"
                     /sec_met_domain="PF00561 (E-value: 2.7e-23, bitscore: 81.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.5e-18, bitscore:
                     64.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIFSAYDTTPLAYRLVGEGEPLICLPGGPMRASAYLGDLGGLAA
                     RRQLVLADLRGTGDSGVPEDPSTYRCDRLVDDVEALREHLGLDRIDVLTHSAGADLALL
                     YAARHPERLRTLTLITPSTRAVGIEVTDQDLRESAELRRDEPWYPEARAAQEALLAGGP
                     FAELWPAVRPLTYGRWDEAARAHAEASAGQTNPEARDHYAAEGAFDPAATAAALREVTV
                     PVLVLAGEYDGHPSPDRATELAALFPHAEFVVQRGAGHFPWLDDPGAFARTVAAFLDPE
                     ILSVQAGGVRLAHRVWGAPEAPPVVLLHGRAGSGATWTRIAEDLAADHRVYAPDFRGHG
                     LSDWPGRYSFEMFRDDLHAFLEARNLAGATVVGHSMGGVAAYLLAQREPDLIGRLIIED
                     APPLYPLDPPRPLSVRPAGDLDFDWPVVPDTDAQLNDPDPAVPGRFPEITAPTLVIGGG
                     PASHIDQEQLVRMVRAIPDAELVTIDAGHLIHTDRPEEFLAAIRSFGLTDRKGGGGAC"
     CDS_motif       complement(20233..20283)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KV381_RS00920_0002"
                     /evalue="3.90E-05"
                     /label="NRPS-te1"
                     /locus_tag="KV381_RS00920"
                     /protein_end="387"
                     /protein_start="370"
                     /score="16.2"
                     /tool="antismash"
                     /translation="VVGHSMGGVAAYLLAQR"
     aSDomain        complement(20593..21330)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KV381_RS00920_Abhydrolase_1.1"
                     /evalue="3.10E-26"
                     /label="KV381_RS00920_Abhydrolase_1.1"
                     /locus_tag="KV381_RS00920"
                     /protein_end="267"
                     /protein_start="21"
                     /score="84.4"
                     /tool="antismash"
                     /translation="PLICLPGGPMRASAYLGDLGGLAARRQLVLADLRGTGDSGVPEDP
                     STYRCDRLVDDVEALREHLGLDRIDVLTHSAGADLALLYAARHPERLRTLTLITPSTRA
                     VGIEVTDQDLRESAELRRDEPWYPEARAAQEALLAGGPFAELWPAVRPLTYGRWDEAAR
                     AHAEASAGQTNPEARDHYAAEGAFDPAATAAALREVTVPVLVLAGEYDGHPSPDRATEL
                     AALFPHAEFVVQRGAGHFPWLDDP"
     CDS_motif       complement(21073..21111)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KV381_RS00920_0001"
                     /evalue="6.60E+00"
                     /label="NRPS-te1"
                     /locus_tag="KV381_RS00920"
                     /protein_end="107"
                     /protein_start="94"
                     /score="-0.4"
                     /tool="antismash"
                     /translation="HSAGADLALLYAA"
     misc_feature    complement(21585..21599)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    22074..22093
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: medium, score: 24.1"
                     /tool="antismash"
     misc_feature    22093..22106
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.89"
                     /tool="antismash"
ORIGIN
        1 cctggcccgc cgttacgccg acgcggcggg ggcgggggcc gagcccgaca ggccctagcg
       61 tccgacgagg cgggtgtcgt cggtcgtcga ggtggtcacg gacgtggtga tgttccccgc
      121 gagacccagc accaggaaca gcaccacgag ccacttcgcg gcgctgctca ggaccagcgg
      181 gcgcgtggcg gagcgcgccg gctcacgggc cacggcgagg tcgccgtcgt cgccgaacag
      241 gcccttgggg taggccgggg tgagcatcat gacgtacgcg gagaaccgca tccggtagcg
      301 cagggtggcc gccgtcgcct cgaacagcgg gcggggcatc cggccgaggc acagcgtgat
      361 cagccaccag acgaaggcca gcgcccacca cccgtacacg gcgaggctct gcacgatcgc
      421 cgccgggatc atcaggaaga cgcggaacag cacggccagg cggttgagcg gggtgggccg
      481 cacctcgatc cgcgccggat agtcggccgg cggggtcagg gcgaagggcg ggtagcggtc
      541 gatgagcagc atgtcgctcg ccgatacgcg catgtcgtag ccgaggacgc cggccaggaa
      601 gcggaagacg gggtcgggca gccgccccag caccagggcc gcgaaccagc ccacgatcac
      661 ggtgaagaac gccgcgatgt gcaggaagaa cagcacgatg aagtgcggga tgagcagcag
      721 aagtcgcaga aggacggtca gccgccgctg acgtgccggt tcgacgatgt ccaggacggg
      781 cctgaactcg tccgcgtcca tctccttgcg gcccgggctc cactggcctt cggccatgtc
      841 gctcctcctc ggcagggcgt ccgtacggca tccgcgcgca ggacgtgtcc ccaccgtgcg
      901 tccggtccgg gccacccgca aacggcccgg gcccgaacgg gtgccgcgct cagcggctgc
      961 ggacgcgggt acggacgcgg tcgaggaggg agcggggctt cttcgtgcta gtgcccttcg
     1021 tggcggcggt ctttgtgccg gcgggcttcg tggcggtgcc cttcttcccg gcggacttcg
     1081 tcctcgtgcc cttcgcaccg gccggcttgg tgcgagcggc cttcgcaccg gcggccttcg
     1141 caccgggcgg cttcgtacga gcggccttcg cgccggcggt aagcctcggc gtgcgcttcg
     1201 gctcgggagc gggctcgggc tctgccggac gttcggaagg ggcgggaacg tcggcgtaca
     1261 tgtagtagcg gtgggtgatc cggcggccca gcacgaagta gcccagcagc gcgcccgccg
     1321 tgttgaggat gacgtcgtcg atgtcgaagg cgcggcccgc gaccagcgcg ccctggatca
     1381 gttcgaccac ggccatggcg acggccgtca gcaacgtcat ccggatcatg cgcagccgac
     1441 gcggtacgaa gaacggcagc aggagaccga acggcacgcc gagcagcagg tttccgcccg
     1501 cctgtttgca cgcggcgagg aaggtgtagt cctcggcgta ctggcgcagc gagcgaccgg
     1561 ggcggaggtt cgacgtcacg aggtcctcgg aggccggtga gggcgtgagc gtcaccttgg
     1621 ccaacaggac ggagaacacc accagtccca gcagcaccac cgtcaggacc gcgccgcgca
     1681 ccaccacacg tacccatgtc ccctggcgtg tccggggatt cgcctctgct gtcatggccg
     1741 acgagtgccc cggcccggcc ggaacacact cctcggcggc ccggtgggac gaaatctcac
     1801 ccgcccgtcc gcgacctcct gcgacgatgt gcgcatgagc gcacggacga agaaggacct
     1861 gttggacgag gccgaccggt tgcgtaccgg aggccggccc gaggaggcgc gcgagcggct
     1921 tctcgccctg accgccgagt accccgacga cgcggaggtg gcctaccgca cggcgtggat
     1981 ccacgatgtg ctgggcctgg agtcggaggc cgtgccgtac tacgagcgtg cgctggccaa
     2041 tccggagctc gccgaggagg accggcgcgg ggcgctcctg ggcctgggca gtacgtaccg
     2101 ggtcctcggc cggtacgggc aggcggtgga gacgctgcgc cggggcgtcg aggagttccc
     2161 ggaccacggc gcgctgcggg cgttcctggc gatggccctg ttcaacaccg acgagcacca
     2221 cgaggcgatg cggctgttgc tggagttgac cgccacgacc agccaggatc cgtcggttca
     2281 ggagtaccgg cgggcgatcg agcactacgc caaggatctg cacgagaccg tgtgacggcc
     2341 gcgcgcgtga ggctttcggc cgcggcgcgc cgcagcgtgg gcgacgcgcc ggtccgagag
     2401 gggtgggtgc cgagaatgct cgggtgccca ccgctccccc ggcgcccccg ccgtctccgc
     2461 cccgctcgac ctcttccgcc gcgccccggc ccggtgatct gccgtggcgc ggcgagggag
     2521 cgctgcttct cctgtccgcg gcttccgggg cggcggacgc gttcgtcttc ctgtgcgtgg
     2581 ggcaggtctt cgccggggtg atgaccggga acctggtgct gctcggggcc tcggccgccg
     2641 gtgcgggcga gaggggcgtg gcgctgaagg tggccgtggc cctgggcgcg tacttctgcg
     2701 gggcggcggc gggtgcgctg atggccgggc ggctcgggct ccgggttccg gtgctgctgg
     2761 gagcggaggt cgttctgctg ggggcggcgg ccgtgctgtg ggggctggag ctggtctcct
     2821 cgtacgggga ccggctcggg ttgctggccc tggtggcggt cgcgatgggc gtccaggggc
     2881 gcgtacgggt gacgccgacg aactacttca ccgggacgct gacctcgctc gcgggccggg
     2941 tggccctgcg ggagctccgg ggtggggacg gctgggtgct ggggcggctg gccgcggtgg
     3001 tggcaggggc ggcggtcgcg gccctggccg agcggtggtg gagcccgggg gccgcgttgg
     3061 gcgcgctggt gccggctgcc ggtgcgctgg tgctggagac ggccccgctc cggggcggcg
     3121 ggccgcggcc ggacaggggg aagccccggc cggatcgggg gaatccagcc ggggcggctt
     3181 gagtgcgggc gtgaagggcg gtcgcctctc ggcgaaaggc tccatggggc ttcggtcgtc
     3241 cgatcgtccc catgggctat aggtgaggcc cggggacact gtccccctca cacccacgta
     3301 tagatgaacg ataaaccatc ctggactgtt cccgggaacc cgccaccgcg gatgtgatcc
     3361 acggcacgga atcccggact ccaccgctgg tcagcgctcg ttcgggtcag cttccggacg
     3421 tctcgccggt gccgtaacgg cgccggaact gttcgacccg gcccgccgtg tcgaccacct
     3481 ggcgcccgcc cgtgtagaac gggtggctcg ccgacgaggt ctcgacgtcg atgacggggt
     3541 aggtgttgcc gtcctgccac tgcacgcgct cgccggagtc ggcggtcgag cgggtcagga
     3601 aggcgacgtc ggccgcgcgg tcgcggaaga ccacgggacg ggagacgggg tggatacggg
     3661 gcttcatcga tgcgttcctt cctcaccacc gagagcggtg acaaacagga gatggacttc
     3721 ttccggccgg cggacccggt cggtcagcgg gtctcgcgga acagcacgtg ccggccggcg
     3781 gcggagtcga acttgcggag ctccagccgg tcgggggtgt tgcggcggtt cttgcgcgtc
     3841 acgtagctcc ggcccgttcc ggcggtggag cggagagtga cgacgggcct gatctcactg
     3901 cgtgccatgg gcgcctccct gatacctctg ccgaccccac tcccgtatcg ggaatgggat
     3961 tcgttttcgt tctggtgagg taacgcgagc caccccctcg gcattcccgc cccaccaccg
     4021 gccccgaacc atgtggtcaa ctcgccccga acgcatgcct gttcggatta tcatcacgcc
     4081 ggagagccgc tggcatatgc cagacgcacc aacgcatcga gtgttgccaa atcccttacg
     4141 gcctgccgtg gcctgtgcga cagtcggtag cggtccaccc ttcagaaccg gctaggccgc
     4201 gcctgtatcg gagtacgaga tgccgtcccc cctcttcgcg gaccgccccg caccacagcc
     4261 tcccgcgcac gacgccgtcg acgacctgat ccaccggacg cgtcggctcc ggggggatgt
     4321 ggacgccgtg cggcgggacg ccgccctgtt cgacgaggac gacccccagc tgcgctggca
     4381 gcgcgccctg tgcgagctgg ccgtgcacca cctggacaat ctcgacgagc acctgggcca
     4441 gctcagggcg ggtctgccgg gtccgcgcac cgaggactcc gctccccggg acgacgaggc
     4501 cccggccggg ccgggagccg gttccccgcc gaaccgggtg ggcagcgccg agtggaacct
     4561 cctcaccgac gagtccagct ggtccgacga gctgtacgag atcttcggca ggccgcccgg
     4621 gtccacaccc ctctcgctgg acgacctgcc gtccgtgctg ctgcccgagg accagccgct
     4681 gctgaccgcc atggtgacgg gctgcctcgt cgacggccgg ccgatggacg gcgagttccg
     4741 catcgtgcgc cccgacggcg acacccgcac actgcacatg acgggcgagc cggtcctgga
     4801 cgccgagggc tgcaccgcct cgatgtgggc ggtgctgcgg gacgtcagcg agctgcgccg
     4861 cagcgagcag gccgtgggca ggagccgtgc gtcggtgcgg cgcgagaagc acatccagcg
     4921 gaccgagcac cgtatggcgg tggagctcca ggagaccgtc ctgccgccgt ggcgcggctc
     4981 gctccgcctc ccggcccggg gtcccggggc cctggacatc gccgcgcact atctcccctc
     5041 ggcgtcgagc gggctcatcg gcggcgactg gtacgacgcg atggagctcc cggacggacg
     5101 caccctgctc accgtcggcg acctcaccgg gcacggcatc cccgccacct cggcgatggc
     5161 gatgatgctg ggcgcgctgc ggggcatggc ggtcgccggc atcgagccgg gcgcgctgct
     5221 gggccacctc aaccaggtcc tcgaaacgtc ggtccagccc gcgctgggca gcgccctgtg
     5281 ctgccgtttc gaccccggca cctcccttct gtcctgggca caggccggac accccgcacc
     5341 gctgctcttc cgcgacggtt cgggacggct cctgccgccg ccggacggca tgctgctcgg
     5401 cgccgcgtcc aacgtcgtct tcgagcagga cgacgtacgg ctgctccccg gcgacgtgct
     5461 cgtgctgcac accgacggcc tgacccgacg cggcgaccgg ggtgcgggcc cggaggcatt
     5521 gctcgccctc gcgccccgct tcgccgaggc ccgtacggca caggagtgcg tccggagtgt
     5581 cgtcgaggag ttcggcggga ccgaacgacc ggacgacgcg tgcgtgctgg tcgcccgtat
     5641 cggggcatga ggaagcgccg acgtgtcggg gctgtgtcac agccccgtcg gtgagccctg
     5701 tcagtgagcc ctgtcagtga gtactgccgg tgagcactgt cagagtgtga cggagcgcgg
     5761 aacggcgcgg ccgggccggg tcagatctgt gtgcccttgg ccttcttctg gttcggcaac
     5821 gagagctcga tctcctcacg cagatcctgg attccggcgt atcccgcgaa ctgaccggtg
     5881 agccggtaca tttcgcggag ccggtcccag gtgcggtgcg aggaggtctc ccccatcgac
     5941 accagcgcga gccgggcgta acggtcggcc tgctcggggt cgttggcgat gaagcaggcc
     6001 gaggccagcg agatgtagtc gaagatcttc gaccgctggc gcccgttgat ccgcagctcc
     6061 agggcctgct tggcatggcg ttgggcgatg atcgcggcac ccgggtcgtg ctcggccagg
     6121 gtgcggaagg cgagcgcctg catgccgtgc atatcggcct cgtcgaacat ctgcatccaa
     6181 ctgggcggcg gcacatcgcc cttgtccgac acgaagagct cctcggcctc gccgagggtg
     6241 cgccgcatgg cctggccacg gcccatcgac gcctgtgccc aggcctcgat ggtgcgcagc
     6301 atcgcctgcg tacggggcag ggtctcgtcg ccggagccgg acttggcgag cttcatcaga
     6361 tcgagcgcgt cgtcgggccg gcccaggtgc accatctggc gcgccgcccg ggagagcgct
     6421 tctccggcgc gtggccggtc gccgccctcg cgggccgcgt gcgcggcgat gacgaagtac
     6481 ttctgggcgg tgggctcgag gccgacgtcg tgggacatcc agcccgccag gacggcgagg
     6541 ttggcggcga cgccccacag gcggcgctgg agatggtcgg ggtggcggta ggcgagcatg
     6601 ccgcccacct cgttgagctg gcccacgacc gccttgcgct gaagtccgcc gccccgggac
     6661 gcgtcccagg cgcggaagac ctcgaccgaa tgctccaggg cctcgatctc ctcggagccc
     6721 accggagcgg cctcgtaccg gtcgaaaccg gcgggatcgg cgtgcagagg atcgctggta
     6781 cgtggagcgt cggccgccag agcggggtcg ctgtgcagcc agtcgtacat ggggccggcg
     6841 atggttgagc cggcggcgag cgcggcgccc gcacccacca agccgcgtcg gttgagcatg
     6901 aggtccattc ccgtgaattc ggtgaggacc gctgccgtcc gttcgggcgc ccacggcaat
     6961 tgatcgggat tgttttccgt cccggagtct cgccgtttcc ccacacgccc gcgtcggccg
     7021 aacccgaggt cctcgatggt cacgacacgg ccgagccgct cggtgaacag agccgccagc
     7081 acttcgggca cgggatcacg gggggattcc cccatgtcga tccagcgcct gacccgcgag
     7141 gtgtcggtgg ccagctgcgg gtggcccatg gccgccgcct gccggttcac cattctcgcg
     7201 agttcgccct tggaccagcc ggccaggccg aacaggtcgg aaagacgggt gttgggttct
     7261 ccggtcactt caagccccca ggttctcggc tgacttgaca ctaaccccct gtcagatgcg
     7321 ctgtgactat tcgccagggt tcgccagggt ccgccagatg gtctgccacc cgcgacgcgg
     7381 tgtcaggtag gaaagcgcca ccccgcccgg cagccctagg tactccccag ggtgccgaac
     7441 ggccgtcggc cgggttggcg cacgtacctt gtcggcgcac gaagggatct gtctcgccca
     7501 tgtacacagc atcgtcctcc gtgtccgccc cgcctcgtcc gctccgcccg atgggcgccg
     7561 gcggcggccc ctatctcgct cctcacgccg gcgcaccggc gcagggtccg ggccgggccc
     7621 gacgggccgc gggaccgggc gccggaccgc tcagcggacg catcgacctg tccggcccgc
     7681 agggcgcgca ggtgcggatg gccatcgcct ccgtccagcg catctgcccc gagttcaacc
     7741 cggtccaggt gctgcgccgc agcggccgtt cggtcctgat cgtcggagcg accgggcggg
     7801 ccaccgccgt cgcgaagtgt ttactggacc actcgccggc ctggaccgag cggttccggc
     7861 acgaaatagc ggcgtaccgc gcgttcgtcc ggcaccgccc cccggttcgg gtgccccggc
     7921 tgatcgcggc ggacccggag aactgcacgc tggtgatcga gcggatgccc ggccgggtcg
     7981 ccgccctcac ccggcatccg gcggaggcgc cgccgcgggc cgacatccgt gccgcgctgg
     8041 gcgcgatcgc ccgggtgaac gcctggcggc cgccgcccgg actgttcgag gcgccgctcg
     8101 actacgcctc gcggatcgcg cgctaccacg agctcggtct gttcaccgac cgtgacctcg
     8161 gcgatctgca gaagctgctg cacggcctgg cccacgcggg cggccggcag ggcatggggc
     8221 agttctgcca cggggacgcg ctgctctcca acatcctgtt gtcgccgacc gggccggtac
     8281 tcgtcgactg ggagcacgcc ggctggtatc tcccggggta cgacctggcg acgctgtggg
     8341 cggtgctggg cgacgcgccg gtggcgcgcc gccagatcag ccagctggcc caggccaggg
     8401 gcccggccgc gcgggacgcg ttcctggtga acctgatgct ggtgctgact cgcgagatcc
     8461 gcaattacga gacggcggtg cagcgcacca tgcgcgaggc gcccccggtg ggggcggggc
     8521 aggaccgccc cggcgcgctc tcctcgggcg aggagcagcg gctgctgctg cggaggctgc
     8581 acgacgactg cgccatggcg cggcgggcgg tgcgggccgc ggtcggcacc cgctgagcga
     8641 cgacggggag aacgaccacg caggacgacg cgggccgacg gcccgcccgc cgagaaccac
     8701 agtgaccgca gcgctgtgaa ggccgtgacc agaccactgt gaagaaggaa gcgcgctgcg
     8761 ggaccggtgc cgacacaccg gtcctgcagc gcgctgttcc ggggcccgga cgggcggttg
     8821 cgaccgccgt ccgggccccg tccgcgcgtg accgggcgct gaccctgtgc tgttccgggg
     8881 gccccggcgg gtgaggcccg ccacgagacc cacgtcacct acgacctccg ataggaggcg
     8941 cgaaccgtcc cgtccggcgt aacgaacagc ccatttggct cataaattgg catctcacga
     9001 tgaagagtag taaaggcggt cattgcttcc catgtcggac agcgctaacc atggatcccg
     9061 gcaagcaccg agtacgagcc cgcgtcgatc gcccaccggc gaacgcggcc cggacacccc
     9121 ggttcctgcc gacgcggcgc gaaggccgcg aagcccgtcc cccataggaa gagctcacgc
     9181 atgccccgca tctccaccct gcgcatcact cgctcgcaca agatcgccac cgctgtgctc
     9241 gtcgcggccg gttcggtcac cgccatagcc gccaccggcg gtgcgagtga ggcgcagacc
     9301 ccccaggccc gctcctccat ctccgtggag ccggtcgccg ccgcgggcat ccccacggcg
     9361 aaggacgccg cggccaagaa ggccgccgag gcgaccgccg ccaaggaagc cgccgcgaag
     9421 aaggccgccg ccaaggccgc cgcggagaag gacgccaccg aggcgcgctc cgagaagcag
     9481 gccgccaacc gctccaccga gcgcaaggcc gtcacgccga agaagttcgc gaacaacctc
     9541 gacggctgga tccgcgagtc gctcgacatc atgaagaaga agaacatccc cggctcctac
     9601 gaggggctgc accgcaacat catgcgcgag tccagcggca acccgaacgc cgtcaacgac
     9661 tgggacatca acgcgcggaa cggcattccc tccaagggtc tcctccaggt gatccagccc
     9721 accttcgacg cgtaccacgt caagggcacc ccgaagaagc tcaccgaccc ggtcgccaac
     9781 atcaccgccg ccgcgaacta cgccgcggac cggtacggct cgatcgacaa cgtcgactcc
     9841 gcctactgag cgaccgactt ccgagcacgc acaggccaaa ccgcgatgat ctgactaatc
     9901 gccgtcgtgc gtgctccgta tggccgaagg gtagtgctgc gcggacacca ccggtccgcg
     9961 cgtttccccg cgcggaggct tctggaaagg cctgacgcac atggcacagc ccttctcact
    10021 gccggatttc tatgttccgt atccggcgcg gctcaaccct catgtggagg cggcacgcac
    10081 gcacacccgg gcgtgggccc gctccatggg gatgctggag gggtccggca tctgggagga
    10141 gaaggacctg gaagcgcacg actacgccct gctgtgcgcc tacacccacc ccgactgctc
    10201 ggccgaggcc ctgtccctgg tcaccgactg gtacgtgtgg gtcttcttct tcgacgacca
    10261 cttcctggag ctgttcaagc gcacccccga ccgggagggc ggcaagcggt atctggaccg
    10321 gctgcccgcc ttcatgccga tggagcgagg cgccccgacc ccggagccgg agaacccggt
    10381 cgaggcgggg ctcgccgatc tgtgggcccg gacggtcccg gcgatgacgg acgcctggcg
    10441 ggcccggttc gcggagtcga cggagaacct cctcaacgag tccctgtggg agctcgccaa
    10501 catccacgag ggccgcatcg cgaaccccgt cgagtacatc gagatgcgcc gcaaggtggg
    10561 cggtgcgccc tggtccgcgg gcctggtcga gtacgcggcg aacgcggagg tgccggcgtc
    10621 ggtcgccgga tcccggccgc tgcgggtgct gcgggacgcc ttctccgacg cggtgcacct
    10681 gcgcaacgac ctcttctcct accagcgtga ggtggaggac gagggggaga acagcaacgg
    10741 cgtgctggtg ctggagaagt tcctcgactg ctccacgcag gaggccgccg acgcggtcaa
    10801 cgacctgctg acctcacggc tccagcagtt cgagaacacc gccctcaccg agctcggccc
    10861 gctctgcgcc gagaagggcc tggacccgac cgagaccgcc gccgtgctgg cgtacgtcaa
    10921 ggggctccag gactggcagt ccggcggcca cgaatggcac atgcgctcca gccgctacat
    10981 gaacggcggc ggcgcgggcg aggccgtggc cggtttcggc atgtccgccg cctccatcaa
    11041 actcacgctc cgctcggaga ccgcgcgggc ccgcagccac agtcatgtgc cgtaccagca
    11101 cgtgggcccc tcgctgctgc cggacttcga cctgccgttc ggcaccacgc tgagtcctca
    11161 tctggagggg gcccgggtcc ggctcgtcga gtgggcgcgg cggatgggca tcctggaggc
    11221 ccagccgggc gtgccgggtt cgcacatctg ggacgagcgg cggatcgtcg cgatcgacct
    11281 gccgctctgc gcggcgggcc tgcatccgga cgcgaccccg gacgaactgg acctgtcctc
    11341 gggctggctg gcctggggaa cgtacgggga cgactggttc ccggtggtgc acgggcgggc
    11401 ccgggacctg acgggggcgc ggctggccaa cgaacggctg tcgctgttca tgccgctgga
    11461 cggcgagggg acgccggagc cggtgaacgc cctggagcgg agtctggccg acctgtggcg
    11521 caggacggcc gcgccgatgg acctgagcgc gcggcggacc ttccgtacct cgatcgagtc
    11581 gatgaccgag agctggctgt gggagctggc gaaccaggcg cagaaccgca tccccgaccc
    11641 ggtggactac gtggagatgc ggcgggcgac gttcggctcg gatctgacga tgagcctgtg
    11701 ccggctcggg cacggcagga ccgttccgga cgaggtctac cgcagcggtc cgatgcgttc
    11761 cctggagaac gcggcggcgg actacgcctg cctgttgaac gatctgttct cgtaccagaa
    11821 ggagatcgag tacgagggcg aggtgcacaa cggcgtcctg gtcgtgcaga acttcttcgg
    11881 cgtggactat ccgacgggcg tggcgatcgt gcacgacctg atgaattccc ggctgcggca
    11941 gttcctgcat gtcgccgagg tcgaattccc ggtgctgtac gacgacttcg acctcggcgc
    12001 cgaggctcgg gagatcctgg cgggctatgt gcaggagctc aagcactgga tcgcggggat
    12061 cctgatctgg caccggggct gccgccgcta ccgtgaggag gatctgcggc aggggcacga
    12121 cacgccctgg cacctgagcg gccccacggg gctcggcacc tcggcggcgc aggtgactcg
    12181 gctgatggcc caactggcag gtagtgctgt gtagttgacg attccgcggc ccgtcgtacg
    12241 gaggaacgcg cggcgggccg cagccgacgg aacaggccgc ccggcatatg cgggcggcct
    12301 atggagatac gtttcagcct tgctggaaca gctccgcggg caggggcttg agcagggtgt
    12361 acaggtcgtc ggtgatcggc cggtcccagc tggcgatggt caccaggacg ccgtcgctgc
    12421 ggtcgaactg gacgcaggcg atccggctct cggagagctt gacccggcgg acgatcagca
    12481 gattgtcgcc ctgcatgacc gggacgtcct cggagctgac gacctcgatc ggctcgtcgt
    12541 tctccagggc gaggagcagc tgggccacct cgaaggggac ctggccctcc tcggtctcgc
    12601 gggcgggcga gccttccggg aggttgccga tgatcatcgc cgggccccgg ccgccgtaca
    12661 ggtcgtaacg gaggaagacg ccctggcagc tgccgtcagg ggcggggagc agaccggcgc
    12721 cgaggttgcc gggccagtcc ccggggtcca tggccaggac gtcgaagtcc gggcccgcgg
    12781 gtgttgcggc gctacggcgg cggaggaagg acatgcctgc catgttacgt gtcccggctc
    12841 acgttgcgga gccgggcccg ggccccgtgg gaccgggccc gccgcgttct ctcagccggg
    12901 cgggggctcg gaccccacga gccacatggc gaagaactgt gcccctcccc cgtacgcgtg
    12961 accgagcgcc ctcgtggccc cgtcgatctg gtgctcgccg gcccgcccgc gcacctggag
    13021 ggccgcctcg gcgaagcgga tcatgccgga cgcgccgatg gggttggtgg acagcacgcc
    13081 gcccgacggg ttgacgggaa ggtcgccgtc gagttcggtg acgcccgcct cggtgagctt
    13141 ccagccctcg ccctcgtcgg cgaagccgag gttctccagc cacatcggct cgtaccagga
    13201 gaacggtacg tacatctcga cagcgtcgat ctcgcggcgc gggtcggtga tccgggcctg
    13261 tcggtagacg tcggccgcgc agtccttccc ggcctgcggg gagacgaagt ccttgcccgc
    13321 gaagagcgtc ggttcgctgc gcatcgcccc gccgtgcacc caggcgggcg ggtggggtgc
    13381 gcgggccgcg ccttcccggc cggtgaggat catggcgcag gcgccgtcgg aggaggggca
    13441 ggtctcggag tagcggatcg ggtcccagag catgggggcg gcccggacct tctccagggt
    13501 gatgtcgtgg tcgtggaggt gcgcgtaggg gttcttcagc gcgttgcggc ggtccttgta
    13561 cgcgacgagc gatccgacct cgtcgggcgc tccggtacgc cgcatgtacg cgcgcacgtg
    13621 cggggcgaag aagccgcccg ccccggccag cagcggctgc tggaagggga cgggcaggga
    13681 gagcccccac atggcgttgg actcggactg tttctcgaag gcgagggtga ggacggtgcg
    13741 gtgcacgcgg gcggcgacga ggttggcggc gaccagggcg gtggagccgc cgaccgagcc
    13801 cgccgtgtgc acgcggagca tcggtttgcc gacggcgccc agcgcgtcgg cgaggtagag
    13861 ctccggcatc atgacgccct cgaagaagtc gggcgccttg ccgatcacga cggcgtcgat
    13921 gtcgctccag gtcagcccgg cgtccgccag ggcgcggacg gcggcctctc ggaccagccc
    13981 ggcgatggac acgtcgtgcc gggcggcgac gtgcttggtc tggccgatgc cgacgacggc
    14041 gacgggctcc ttaggcatga gcgctctccc cttccaggac ggcgaccagg ttctgttgca
    14101 ggcagggtcc cgaggtggcg tgcgcgaggg cccggtcgga ctcgccgcgg tggatgcggg
    14161 cggcggcctc gccgagccgg atcagtccgg cggccatcac ggggttggcg gcgagcgccc
    14221 cgccggaggg gttgacgcgg acgtcgtcgc cgagcccgag cgccttgcgc aggacgactt
    14281 cctgcgaggt gaacggggcg tgcagctcgg ctgtgtcgac gggccgttcg aaggctccgg
    14341 cgtgctgggc ggcgagccgg gcggaagggc tgtcggtcag gtcgcggacg ccgaggccgt
    14401 gcgcctcgat gcggtggtcg atgccccgga tccaggcggg ccgttcgcac agctcgcggg
    14461 cggtgtcccc ggcggcgagg accacggcgg ccgcgccgtc gccgatgggc gggcagtcag
    14521 cggtgcgcag cggccgtacg aggtggtcgc cgaccgggac gtcgccggtg agctgggcgt
    14581 acggattacc gacggcggcg gtgcggttac gggcggcaac ctcggcgagg gcgggttcgt
    14641 cggtgtctcc ggcgtcgatg agggcctgcg cctggagggc ggcgagcgcg acggagtccg
    14701 gccagagcgg ggccaggtag taggggtcga gctggcgggt caggacgtcg cggacccggc
    14761 cgggcgagga cttgccgtag gagtagacga gcgcggtgtc cgcctcccct gtctggatct
    14821 tgacccaggc ctcgtacagc gcccaggccc cgtccatctc gacgtgcgac tcggagatgg
    14881 gcggatgggc gccgacaccg tcgagcgcca tggtgaagga gaaggcccgc ccggcgaggt
    14941 agtcggcgga gccggagcag gtgaacccga tctcgttggc cttgaggccg gtcgcgccca
    15001 ggacctcgtg gaggacgggc atcagcaggt cgacctcgga gagctcgtcg gtgcgccgcc
    15061 ggtgtgcact ctgggcgaag gcgacgatgg ccacgtcccg catctacacc agctccttgt
    15121 acgtgtcgta gtcggcgtcg ggctctccgg tgggccggta gtggtccacg tggcgggcgc
    15181 cctcgctcca gacgggctcg acgcgcagcc ccatgcgcac ctggtcgtag gggattccgg
    15241 cgatgcggcc gtggagggcg aggtcggcgc cgtcgagggc gatgtgggcg tagacgtacg
    15301 ggacttcgat atcgaggttc gccgtatgag cagccttgat gttgacgatg cagaacgtgg
    15361 tgaccgtgcc gcgcggtccg acctcgacct gttcggcggt ggcgaccccg caggtgggac
    15421 aggcgccgcg cggcggtacg tagaccttgc ggcaggacgg gcagcgttcg ccgacggtgc
    15481 ggcgttcctc cagggccttg atgtaggcgc tctgggcgcg gcccggggtg tggacgtagt
    15541 cgaggcgggc cggggtgacg atgccggtga cggggtcggc gaactcagcg gtgtgcgggg
    15601 cgggttcgga gccgtcgggc tcaccctcgt acggttcgaa gcaggcgatg tcggtgatgg
    15661 cgccggtgcg ggtcgcggcc cagcggatcc ggacgcgcat cccggtgcgc acggcgtcgg
    15721 gtccgggcgc gtcgagtacg tgcaggagtg cggtgccggc cccgtcgagg cggacgagga
    15781 cccaggcgaa gggggtgtcg agcggctggt cacggcgggg ggccgggttc caggcccagg
    15841 tggtgacggt gccggtgggg gcgacctcga cgaggtcgcg gatctcgttc gcggtgacgg
    15901 ggtcgtactc gacgggtggc acgagcaccg tgccgtcctc cgtgcggaca ccgaggacgg
    15961 tgcgttcgcg cagtccggtg aggaaggcgc tctgcaccgg cccgagcgag cgggtgaagg
    16021 ggaattcgac caccagcggg gcgctgagga cgtcggtcat ggctctctcc tcgggtcagg
    16081 cgcgccggta gacgggcggg cgcttctcgg cgaaggcacg ggcgccctcc ttggcgtcct
    16141 cggtggcgaa cacgggccag ccgcgcttga gttcggcggc cagcgcctcg gtctcggtca
    16201 gctcggcgcc ctcgtagacc gaggccttga cggcctcgac ggcgagcggc ccgcaggcgt
    16261 tcacccgctc ggcgacggcg agggcctcct ccagtgcggt tccgtcgggc acgaccctgc
    16321 cgacgagccc gatggcggct gcctcctcgg cggtgtagga gcggccggtg agcagcattt
    16381 cgagggcgtg ggtgcggggg atctggcggg gcagccggac ggtggagccg ccgatcggga
    16441 agaggccccg gcgcacttcg aagagcccga aggtggcgcc cgctccggcg atgcggatgt
    16501 cggtgccctg gaggatctcg gtgccgcccg cgacacaggg gccttccacg gcggcgatga
    16561 ccggtttgcg ggggcggtgg tggcgcagca tcgccttcca gtggaggtcc gggtcggccg
    16621 tcatccgctc ccggtactcc tcccccgcca ttccgccgcc cgccagcgcc ttgaggtcca
    16681 tgcccgcgca gaacgcgccg cccgcgccgg tgaggacgac ggagcggatc gcgtcgtcct
    16741 cgtcggcctc gatccagccg tcgtggaggc cgacgagcat cggcagcgag agcgcgttcc
    16801 tggcctgtgg tctgttcaag gtgagcacca gcgtggcgcc ttcgcgccgc acggtgaggt
    16861 gttccgtacc gcccatgacc gactcctgtc tccagacctg gaacaggttg caggaggagg
    16921 ggtcgcagtt caatagtttt ctgacagctc gtcagattgt ttcgacgcca cctcttccca
    16981 cttgtgccgc ccggcgctct aatgacggcc gagtcgccag tcatccgggg tcaggaggaa
    17041 cggtggagta caaccttgcc gacctgttcg aatcggtcgc cgacacggtg cccgaccgcg
    17101 aggcgctcct gtacgtcgac catcccggta cgggcgcgga gcggcggctc acctacgcgg
    17161 agctggacgc cgccgccaac cggatcgccc accacctgat cgacgcgggc atccggccgg
    17221 gcgagcacct ggggctgcac ctctacaacg gggtcgaata cctccagacg gtgctgggcg
    17281 ccctcaaggc caggatcgtt ccggtgaacg tcaactatcg ttacgtagaa gaggaattgg
    17341 tctatctcta ccgggacgcc gacctggcgg cgctggtctt cgacggcgag ttcgacgagc
    17401 gggtcgcggc ggccgccccg caggccccgg ggctgcgcca tctgatccgg gtgggccccg
    17461 ccggcgccgc tcccccggcc gggccggtcg tgccgttcgc cgaggcggag gactcgggcg
    17521 cggccgggcg cggcttcgcg gcccgctccg ccgacgacca gttgatcatc tacaccggcg
    17581 gcacgaccgg catgccgaag ggcgtgatgt ggcgtcagga ggacctgttc ttctcgggtc
    17641 tgggcggcgg tgcgccgacc ggtgagccgg tgaaggcccc gcaggagctg gcggagcggg
    17701 tcgccgcggg tggcgacggc atcaccttct tccccacccc gccgctgatg cacgggacct
    17761 ccacgctgac cgcgttcatc ggcttcaact tcggccaacg ggtcgtcgtg caccgcaagt
    17821 tcgtgcccga tgaggtgctg cggacgatcg agaaggagaa ggtcaccagt gtgtcactgg
    17881 tcggcgacgc gatgctgcgt ccgctgatcg actgcctcaa ggggccgcag cgcgggacgg
    17941 actgctcgtc gctgttctcc gtctccagct ccggggcgat catgtcggac tcggtgcggg
    18001 cggagttcca ggcgctggtg ccgacggtga tgctgctgaa caacttcggc tcatcggagt
    18061 ccggcttcaa cggcacggcc accgccgact cggggccgga gaagggcttc cgggtgcagg
    18121 tcaacgcccg tacggcggtg gtcgatccgg tcacgtacga gccggtggcc cccggtgagc
    18181 cgggccgcat cgcccagcgc gggcatgtcc cgctcggcta ctacaacgac ccggccaaga
    18241 ccgccgacac cttcttccgc cggggcgagg aacggtgggt gctgctgggc gacatggcga
    18301 ccgtggacgc ggacggcatc gtcaccgtgc tcggccgggg ctcccagtgc atcaacaccg
    18361 ggggcgagaa ggtgtatccg gaggaggtcg agcaggcgct gaagtcccat ccggacgtgt
    18421 acgacgcgct cgtcgcgggc gttccggacg agcgctgggg caaccgggtc gccgccgtgg
    18481 tccaactccg cgacggggcc gatgcgttga ctctggattc ggtgcagacg cactgccgga
    18541 cgcggctcgc cggctacaag atcccccggg ccctggtgct ggccgaccgg atccagcgtt
    18601 cgccgagcgg caaggcggac taccggtggg cgaagacggt ggcggcggag gccgcgcgga
    18661 gctgaacgac cggccggccg acgcccccgg ccccgggccc ccggtcggca agccctgccg
    18721 ccccggtcgc tgatcgtcaa acgccccgtc gcccatcgtc aaggacaggg cgggaggcga
    18781 accgcagact ggtggggcgg gcgtcggggt gcccggtgcc acgggggtgt gccgagcacc
    18841 tcacccgcct tcgtcagcgc gccggttccg cccggtcccg gagtccggcg tggcggtagt
    18901 cgctggggga catgccgtgg gcggcgcgga acacccggct gaagtgggcg ggcgcgccga
    18961 aaccgcaccg ggcggcgatc gtgtgcagtg gtgtgtgggc cagggcgggg tcggcgaggt
    19021 cccggcgggc ccgttcgagg cgtcggctgc ggatgagtgc ggccaccgtg gtgccctcct
    19081 gctggaagag ccggtgcaga tgccgggtgg agatgtggtg cgcggcggcg acggcggccg
    19141 gggtgagccg ggggtcgtgg agattgcggc cgatgaaggt gcggatggtc aggacgaggt
    19201 tgcgggtccg ggtctccggc gacagggccg tctcccggtc gagcccaccg gcgagcagtc
    19261 cggccgcgag atcgagcagg acccggttca gccggggccc gtcggcggga ccgtaggagt
    19321 ccgactggtc caccagatgg gtgacgaact ggctgaacag cgcgccgaag ccgtgccggc
    19381 cggagagagg ccggccgagc agctcgtcca gcgaggtgct cgtcggcagg ggcagcagcg
    19441 accgggggaa gtccaccccc acccccacga tcggctcgtc gacggtgccg acgtcactgg
    19501 gtctggacac gtcgaggacg tagaggtcgt acggtccgac ggcgctgcgc agcccgccct
    19561 gatcgacgag cacggtcccg ctgccgggca ggaccagcgt catgtggagc agtcccgggt
    19621 cggactgccg gatcagccgg ggtgtgcgcc ggtagcggga ggcgtgcaga caagtgggcc
    19681 acagcaaggt gtcctcgacg cgcaggagcc ggtggtcggc ccagaagtcg tccgcgtgcg
    19741 ggctcgtgat ctccatgggc gcgacgacat cggtcatgca ctgctgccag cgggcgaacc
    19801 ggtcgctccg cggcagggca tcggtcctga accgcccttc ggtcagcacg ccccgccgcc
    19861 tcccttccgg tcggtgagcc cgaacgaccg gatcgccgcg aggaattcct ccggccggtc
    19921 cgtgtggatc agatgccccg cgtcgatggt gaccagctcg gcgtccggta tcgcgcggac
    19981 catccgcacc agctgttcct ggtcgatgtg gctggcgggg ccgccgccga tgacgagggt
    20041 gggcgcggtg atctccggga accgcccggg gacggccggg tcggggtcgt tcagctgggc
    20101 gtcggtgtcg gggaccacgg gccagtcgaa gtcgaggtcg cccgccgggc ggacggagag
    20161 cggccggggc gggtcgagcg ggtacagcgg cggcgcgtcc tcgatgatca gccgcccgat
    20221 caggtccggt tcccgctggg ccaggaggta ggcggcgacc ccgcccatgg agtgtccgac
    20281 gacggtcgcc ccggccaggt tgcgggcctc caggaaggcg tgcaggtcgt cgcggaacat
    20341 ctcgaaggag tagcggccgg gccagtcgct cagcccgtgg ccccggaagt cgggggcgta
    20401 cacccggtgg tcggcggcca ggtcctccgc gatccgggtc caggtcgcgc cggagcccgc
    20461 ccggccgtgc agcaggacga cgggcggggc ctcgggggcg ccccacaccc ggtgggccag
    20521 ccggaccccg ccggcctgca cgctcaggat ctccgggtcg aggaaggccg ccaccgtacg
    20581 ggcgaaggct ccggggtcgt ccagccacgg gaagtgcccc gcgccgcgct ggacgacgaa
    20641 ctcggcgtgc gggaagagcg cggcgagctc ggtggcgcgg tccgggctcg ggtggccgtc
    20701 gtactccccg gccaggacca gcaccggcac ggtcacctcg cgcagggcgg cggcggtggc
    20761 ggcggggtcg aacgcgccct cggcggcgta gtggtcacgg gcctcggggt tggtctgtcc
    20821 ggccgaggcc tcggcgtggg cgcgggccgc ctcgtcccag cggccgtacg tgagcggccg
    20881 gacggcaggc cacagctccg cgaagggccc gccggcgagc agcgcttcct gggcggccct
    20941 ggcctcgggg taccagggct cgtcgcgccg cagttcggcg gactcgcgca gatcctggtc
    21001 ggtcacctcg atgcccacgg cccgggtgct gggcgtgatc agggtgaggg tgcgcagccg
    21061 ttccgggtgg cgggcggcgt acagcagggc gaggtccgcg cccgcggagt gggtcaggac
    21121 gtcgatccgg tcgaggccca ggtgttcgcg cagcgcctcc acatcgtcga cgaggcggtc
    21181 gcaacggtac gtcgaggggt cctcgggcac cccggagtcg ccggtgccgc gcaggtccgc
    21241 gaggaccagc tgccgacggg cggcgagccc gcccaggtct ccgagatacg cgctcgcccg
    21301 catcggcccg ccgggcaggc agatcagcgg ttcgccctcc cccaccaggc gataggcgag
    21361 cggggtcgtg tcgtacgcgg agaagatcgg catacgccac atccaaacag gaacccgtgt
    21421 gcggacgcac cggacttcgc gggaagctga tccacggcga tgtgtgcgcc cctcttgcca
    21481 gcgcccccgg cctcctgaat tactgcaccc aggaagatcg accgaatgat cggtcgcccg
    21541 cttcgggaga ggaagggtcc ccatgacggc catgctggac gcggcggaac ggctcggccg
    21601 gggcgagctg gaggccctgc aacgggagcg gctccgcgcc acgctgcggc acgcgtacga
    21661 caaggtcccc ttctaccgga acgccttcga ccgcgccggg ctgaagcccg aggactgccg
    21721 gacgctcgcc gatctggccc ggttcccgtt caccacgaag gcggatctgc gggacaacta
    21781 ccccttcggg atgttcgccg tgccggagca cgaggtgcgc aggatccacg cctccagcgg
    21841 cacgaccgga cgtccgacgg tcgtcgggta caccgagcgg gacctggacc actgggcgga
    21901 cgtggtggcc cgttcgatcc gggcggcggg cggacggccc gggcacaagg tccatgtggc
    21961 gtacggatac gggctgttca ccggcggcct cggggcgcac tacggggcgg agcggctggg
    22021 ctgcacggtg atcccggcct ccgggggcat gaccgcgcgc caggtccggc tgatccagga
    22081 cttccggccc gagatcatca tgatcacgcc gtcgtacatg ctgacgctgc tggacgagtt
    22141 cgagcggcag ggcgtcgatc cgaggtcgac gtccctgaag gtcgggatct tcggcgcgga
    22201 gccgtggacc gagg
//
