GCF_019200975.1 - 16 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAHTMR010000034.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	hydrogen-cyanide	10,637	23,450

NZ_JAHTMR010000009.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	betalactone	26,242	49,487

NZ_JAHTMR010000012.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	NRPS	14,960	67,958	Low	Pf-5 pyoverdine	NRPS:Type I
Region 4.2	NAGGN	187,163	202,058

NZ_JAHTMR010000013.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	redox-cofactor	58,755	80,926

NZ_JAHTMR010000014.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	ranthipeptide,NRP-metallophore,NRPS	3,067	87,346	Low	Pf-5 pyoverdine	NRPS:Type I

NZ_JAHTMR010000019.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	NRPS-like	1	25,084

NZ_JAHTMR010000001.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	RiPP-like	496,491	507,330
Region 12.2	RiPP-like	805,219	817,420

NZ_JAHTMR010000035.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	betalactone	1	20,039

NZ_JAHTMR010000003.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	RiPP-like	120,251	131,438
Region 33.2	terpene-precursor,betalactone	387,537	419,627

NZ_JAHTMR010000006.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 38.1	terpene-precursor	74,494	95,381
Region 38.2	lanthipeptide-class-ii	199,209	222,289

NZ_JAHTMR010000007.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 39.1	arylpolyene	86,486	130,103	Low	APE Vf	other:other

NZ_JAHTMR010000008.1 (Pseudomonas sp. PD9R)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 40.1	NRPS-like	62,574	105,402

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	hydrogen-cyanide	10,637	23,450
Region 2.1	betalactone	26,242	49,487
Region 4.1	NRPS	14,960	67,958	Low	Pf-5 pyoverdine	NRPS:Type I
Region 4.2	NAGGN	187,163	202,058
Region 5.1	redox-cofactor	58,755	80,926
Region 7.1	ranthipeptide,NRP-metallophore,NRPS	3,067	87,346	Low	Pf-5 pyoverdine	NRPS:Type I
Region 11.1	NRPS-like	1	25,084
Region 12.1	RiPP-like	496,491	507,330
Region 12.2	RiPP-like	805,219	817,420
Region 28.1	betalactone	1	20,039
Region 33.1	RiPP-like	120,251	131,438
Region 33.2	terpene-precursor,betalactone	387,537	419,627
Region 38.1	terpene-precursor	74,494	95,381
Region 38.2	lanthipeptide-class-ii	199,209	222,289
Region 39.1	arylpolyene	86,486	130,103	Low	APE Vf	other:other
Region 40.1	NRPS-like	62,574	105,402

No secondary metabolite regions were found in these records:: NZ_JAHTMR010000011.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000015.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000016.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000017.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000018.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000021.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000020.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000022.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000023.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000024.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000025.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000026.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000027.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000029.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000028.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000002.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000030.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000032.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000031.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000033.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000036.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000037.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000038.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000039.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000040.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000041.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000004.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000005.1 (Pseudomonas sp. PD9R); NZ_JAHTMR010000010.1 (Pseudomonas sp. PD9R)

Compact view

NZ_JAHTMR010000034.1 - Region 1 - hydrogen-cyanide

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Location: 10,637 - 23,450 nt. (total: 12,814 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

KUF73_RS30985: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

KUF73_RS30995: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002425.3	0.37	ribosomal	stlassin	Streptomyces sp.
BGC0002747.3	0.36	ribosomal	lentinulin A	Lentinula edodes
BGC0001715.4	0.29	NRPS	octapeptin C4	Bacillus circulans
BGC0002754.2	0.29	NRPS	hectoramide B	Moorena producens JHB
BGC0000344.5	0.29	NRPS	entolysin	Pseudomonas entomophila L48
BGC0001553.5	0.28	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000381.5	0.28	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0001964.2	0.27	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002679.2	0.27	NRPS	chromobactin	Chromobacterium violaceum ATCC 12472
BGC0001590.5	0.27	PKS	formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E	Streptomyces sp. KY5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002425.3	0.37	ribosomal	stlassin	Streptomyces sp.
BGC0002747.3	0.36	ribosomal	lentinulin A	Lentinula edodes
BGC0001715.4	0.29	NRPS	octapeptin C4	Bacillus circulans
BGC0002754.2	0.29	NRPS	hectoramide B	Moorena producens JHB
BGC0000344.5	0.29	NRPS	entolysin	Pseudomonas entomophila L48
BGC0001553.5	0.28	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0000381.5	0.28	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0001964.2	0.27	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002679.2	0.27	NRPS	chromobactin	Chromobacterium violaceum ATCC 12472
BGC0001590.5	0.27	PKS	formicamycin A, formicamycin B, formicamycin C, formicamycin D, formicamycin E, formicamycin F, formicamycin G, formicamycin H, formicamycin I, formicamycin J, formicamycin K, formicamycin L, formicamycin M, fasamycin C, fasamycin D, fasamycin E	Streptomyces sp. KY5

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (1):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.97 out of 26.33

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_JAHTMR010000009.1 - Region 1 - betalactone

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Location: 26,242 - 49,487 nt. (total: 23,246 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KUF73_RS18035: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

KUF73_RS18060: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase

KUF73_RS18020: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

KUF73_RS18030: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: peptidase

KUF73_RS18005: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase

KUF73_RS18025: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

KUF73_RS18040: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

KUF73_RS18045: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001128.4	0.55	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002284.3	0.54	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000312.4	0.41	NRPS	bassianolide	Beauveria bassiana
BGC0000595.3	0.40	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0001128.4	0.55	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002284.3	0.54	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000131.5	0.45	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002711.2	0.41	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000312.4	0.41	NRPS	bassianolide	Beauveria bassiana
BGC0000595.3	0.40	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.51 out of 30.11

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.98 out of 27.04

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16

Confidence: strong

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.39 out of 31.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.74 out of 32.74

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.29 out of 27.78

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.54 out of 30.11

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.88 out of 27.55

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.09 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CelR	Cellobiose uptake repressor
DasR	N-acetylglucosamine dependent repressor

NZ_JAHTMR010000012.1 - Region 1 - NRPS

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Location: 14,960 - 67,958 nt. (total: 52,999 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KUF73_RS21440: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

KUF73_RS21570: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

KUF73_RS21580: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: aminotransferase carboxylase transferase

KUF73_RS21495: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

KUF73_RS21575: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

KUF73_RS21590: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: dehalogenase

KUF73_RS21535: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: hydratase

KUF73_RS21585: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

KUF73_RS21530: disulfide isomerase/thiol-disulfide oxidase

smcogs: SMCOG1233: disulfide isomerase/thiol-disulfide oxidase

Ligases: ligase

KUF73_RS21540: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.73	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.68	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.10 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.48 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.85 out of 28.19

Confidence: medium

Additional weak hits (18):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.95 out of 26.06

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.36 out of 25.88

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.57 out of 27.78

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.83 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.75 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.93 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.89 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.11 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.62 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.08 out of 21.55

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.09 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.05 out of 36.54

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.75 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.95 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.72 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.09 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.14 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 14959 - 67958:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - Glu - D-Tyr - Dab)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KUF73_RS21540: NH2 - Glu - Tyr - Dab

Search NORINE for peptide: strict or relaxed

CAL_domain (41..477): NH2

minowa: NH2

Prediction, score:

NH2: 160.4
AHBA: 22.9
fatty_acid: 15.8
shikimic_acid: 7.4
Acetyl-CoA: 1.3

AMP-binding (1131..1528): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMAFDVSVWEWHFFSGGEHNRYGPTETAINVTH
Nearest Stachelhaus code(s):: Glu DVWHFGRINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2190..2594): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HAVYFDAATERVGFITGGEFNAYGPTETVVMPLA
Nearest Stachelhaus code(s):: Tyr DAEGIGAVMK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3723..4129): Dab

nrpys: Dab

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NSKAFDISVWQAESLPTGEVNAYGPAECSDDVAF
Nearest Stachelhaus code(s):: Dab DIWELTADDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_JAHTMR010000012.1 - Region 2 - NAGGN

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Location: 187,163 - 202,058 nt. (total: 14,896 nt) Show pHMM detection rules used

NAGGN: ((TIGR03104 or cds(GATase_7 and Asn_synthase)) and TIGR03103 and (TIGR03106 or Peptidase_M42))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

KUF73_RS22220: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

KUF73_RS22255: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: hydrolase

KUF73_RS22225: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001880.3	0.44	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0000846.5	0.42	other (other)	tabtoxin	Pseudomonas syringae
BGC0000888.5	0.40	other (other)	bacilysin	Bacillus sp. CS93
BGC0000885.3	0.40	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0001184.4	0.37	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000234.5	0.36	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001928.2	0.36	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000254.5	0.33	PKS	oxytetracycline	Streptomyces rimosus
BGC0000937.5	0.33	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001739.3	0.33	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001880.3	0.44	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0000846.5	0.42	other (other)	tabtoxin	Pseudomonas syringae
BGC0000888.5	0.40	other (other)	bacilysin	Bacillus sp. CS93
BGC0000885.3	0.40	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0001184.4	0.37	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000234.5	0.36	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001928.2	0.36	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000254.5	0.33	PKS	oxytetracycline	Streptomyces rimosus
BGC0000937.5	0.33	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001739.3	0.33	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.06 out of 32.74

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.20 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.82 out of 30.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JAHTMR010000013.1 - Region 1 - redox-cofactor

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Location: 58,755 - 80,926 nt. (total: 22,172 nt) Show pHMM detection rules used

redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KUF73_RS22825: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

KUF73_RS22830: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: aminotransferase

KUF73_RS22815: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Lyases: cyclase hydratase

KUF73_RS22770: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

KUF73_RS22835: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0000706.3	0.44	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000906.3	0.43	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.43	other (other)	heme D1	Heliobacillus mobilis
BGC0000895.5	0.42	other (other)	citrulline	Lactobacillus plantarum subsp. plantarum
BGC0000258.3	0.42	PKS	prodigiosin	Serratia sp.
BGC0000259.3	0.41	PKS	prodigiosin	Serratia marcescens
BGC0000707.5	0.41	saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000260.3	0.41	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0002675.2	0.40	PKS	prodigiosin	Pseudoalteromonas rubra

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0000706.3	0.44	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000906.3	0.43	other (other)	heme D1	Heliophilum fasciatum
BGC0000905.5	0.43	other (other)	heme D1	Heliobacillus mobilis
BGC0000895.5	0.42	other (other)	citrulline	Lactobacillus plantarum subsp. plantarum
BGC0000258.3	0.42	PKS	prodigiosin	Serratia sp.
BGC0000259.3	0.41	PKS	prodigiosin	Serratia marcescens
BGC0000707.5	0.41	saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000260.3	0.41	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0002675.2	0.40	PKS	prodigiosin	Pseudoalteromonas rubra

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.73 out of 26.85

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 28.19

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 1 - 90; Score: 113.9

TFBS definitions

Regulator	Description

NZ_JAHTMR010000014.1 - Region 1 - NRP-metallophore,NRPS,ranthipeptide

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Location: 3,067 - 87,346 nt. (total: 84,280 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

KUF73_RS23465: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

KUF73_RS23610: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

KUF73_RS23635: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acetyltransferase aminotransferase halogenase

KUF73_RS23460: halogenase

smcogs: SMCOG1119: halogenase

KUF73_RS23575: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

KUF73_RS23675: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Hydrolases: esterase hydrolase

KUF73_RS23535: thioesterase

smcogs: SMCOG1004: thioesterase

KUF73_RS23555: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: hydratase

KUF73_RS23680: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase

KUF73_RS23545: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

KUF73_RS23550: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.88	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.87	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002075.3	0.85	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001128.4	0.84	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.83	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.82	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.81	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001133.4	0.79	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.76	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.76	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001133.4	0.72	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	0.70	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.00 out of 29.72

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97

Confidence: medium

Additional weak hits (32):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.84 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.81 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.47 out of 29.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.05 out of 21.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.01 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.51 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.88 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.95 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.82 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.07 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.31 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.86 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.71 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.40 out of 31.73

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.23 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.04 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.23 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.00 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.43 out of 32.93

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.64 out of 18.57

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.27 out of 32.93

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.04 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.71 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.24 out of 36.53

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.87 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.97 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.94 out of 32.93

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.32 out of 26.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

RREFinder

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 3066 - 87346:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ala - Lys - Thr) + (D-Ser - X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 5753 - 87346:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Ala - Lys - Thr) + (D-Ser - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KUF73_RS23545: Ala - Lys - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (581..969): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: LWSTFDLSVWEVNTNLAGEYDLYGPSEDTTYSTW
Nearest Stachelhaus code(s):: Ala DLWNNALTYK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2065..2478): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FTAAFDGFVEQPDLHVGGELNTYGPTEATVVSSV
Nearest Stachelhaus code(s):: Lys DGEDHGTVVK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3129..3532): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEVNMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

KUF73_RS23550: Ser - X - X

Search NORINE for peptide: strict or relaxed

AMP-binding (515..914): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFICSGEYNLYGPTEAAIDVTH
Nearest Stachelhaus code(s):: Ser DVWHISLIDK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2026..2425): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HSIAFDGAHERTCFTPCGEINGYGPTETVITPLI
Nearest Stachelhaus code(s):: OH-Orn DGEVVGGVTK (76% 8Å match); Cys DHESDVGITK (47% 8Å match)
Stachelhaus code match:: 60% (weak)

AMP-binding (3075..3474): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: lys (Lys)

Stachelhaus prediction details:

Stachelhaus sequence:: HGIMFDGAQERSCFCFGGDVNGYGPTETVVTPLL
Nearest Stachelhaus code(s):: OH-Orn DGEACGGVTK (79% 8Å match); Fo-OH-Orn DGEVCGGVTK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

RRE predictions

: RRE type: Quinohemoprotein_rSAM_RRE; Location: 4 - 85; Score: 86.1

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_JAHTMR010000019.1 - Region 1 - NRPS-like

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Location: 1 - 25,084 nt. (total: 25,084 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

KUF73_RS26805: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

Lyases: cyclase

KUF73_RS26790: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase

KUF73_RS26765: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001249.5	0.60	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001128.4	0.59	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	0.59	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002164.2	0.61	NRPS	peramine	Epichloe festucae
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001249.5	0.60	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001128.4	0.59	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001132.4	0.59	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.80 out of 23.79

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.38 out of 27.78

Confidence: medium

Additional weak hits (7):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.59 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.30 out of 29.38

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.63 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.83 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.94 out of 36.54

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.04 out of 32.93

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 25084:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KUF73_RS26765: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (189..571): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: FWYSFDSSLIDPFLMTGGDYNLYGPTEATVLITA
Nearest Stachelhaus code(s):: Val DALFVGIVLK (76% 8Å match); Leu or Ile DAIYLGVVLK (56% 8Å match); Arg DALFFGLVDK (50% 8Å match); Ala DVFFVGLVAK (44% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JAHTMR010000001.1 - Region 1 - RiPP-like

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Location: 496,491 - 507,330 nt. (total: 10,840 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase methyltransferase

KUF73_RS02285: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

KUF73_RS02310: acyltransferase

smcogs: SMCOG1141: acyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002645.3	0.36	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0002719.2	0.34	NRPS	thanafactin A	Pseudomonas fluorescens
BGC0000536.3	0.31	ribosomal	nisin Q	Lactococcus lactis
BGC0001377.5	0.25	PKS	uncialamycin	Streptomyces uncialis
BGC0000838.3	0.22	PKS	flexirubin	Flavobacterium johnsoniae UW101
BGC0000084.5	0.20	PKS	laidlomycin	Streptomyces sp. CS684
BGC0002374.2	0.20	PKS	pulvomycin B, pulvomycin C, pulvomycin D	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002645.3	0.36	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0002719.2	0.34	NRPS	thanafactin A	Pseudomonas fluorescens
BGC0000536.3	0.31	ribosomal	nisin Q	Lactococcus lactis
BGC0001377.5	0.25	PKS	uncialamycin	Streptomyces uncialis
BGC0000838.3	0.22	PKS	flexirubin	Flavobacterium johnsoniae UW101
BGC0000084.5	0.20	PKS	laidlomycin	Streptomyces sp. CS684
BGC0002374.2	0.20	PKS	pulvomycin B, pulvomycin C, pulvomycin D	Streptomyces sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.87 out of 24.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.57 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.61 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.75 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.08 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.75 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JAHTMR010000001.1 - Region 2 - RiPP-like

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Location: 805,219 - 817,420 nt. (total: 12,202 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

KUF73_RS03705: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

KUF73_RS03725: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001285.5	0.36	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000404.4	0.35	NRPS	penicillin	Penicillium chrysogenum
BGC0001336.5	0.33	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0001484.3	0.32	other (other)	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001080.5	0.29	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000959.5	0.28	NRPS, PKS	aspyridone A, aspyridone B	Aspergillus nidulans FGSC A4
BGC0001333.5	0.27	other (other)	BE-54017	uncultured bacterium AB1650
BGC0001302.5	0.27	other (other)	lomofungin	Streptomyces lomondensis
BGC0000722.5	0.27	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000892.4	0.27	other (other)	caryoynencin	Burkholderia gladioli BSR3

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001285.5	0.36	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0000404.4	0.35	NRPS	penicillin	Penicillium chrysogenum
BGC0001336.5	0.33	other (other)	erdasporine A, erdasporine B, erdasporine C	uncultured bacterium
BGC0001484.3	0.32	other (other)	2'-chloropentostatin, 2'-amino-2'-deoxyadenosine	Actinomadura sp. ATCC 39365
BGC0001080.5	0.29	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0000959.5	0.28	NRPS, PKS	aspyridone A, aspyridone B	Aspergillus nidulans FGSC A4
BGC0001333.5	0.27	other (other)	BE-54017	uncultured bacterium AB1650
BGC0001302.5	0.27	other (other)	lomofungin	Streptomyces lomondensis
BGC0000722.5	0.27	other (cyclitol), saccharide	validamycin A	Streptomyces hygroscopicus subsp. jinggangensis
BGC0000892.4	0.27	other (other)	caryoynencin	Burkholderia gladioli BSR3

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.21 out of 20.47

Confidence: medium

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.45 out of 25.75

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.16 out of 30.22

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAHTMR010000035.1 - Region 1 - betalactone

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Download region SVG

Location: 1 - 20,039 nt. (total: 20,039 nt) Show pHMM detection rules used

Region on contig edge.

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

KUF73_RS31050: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

KUF73_RS31055: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

KUF73_RS31075: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

KUF73_RS31080: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

KUF73_RS31100: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Ligases: ligase synthase

KUF73_RS31060: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

KUF73_RS31090: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport

KUF73_RS31040: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001240.4	0.55	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.55	NRPS	peramine	Epichloe festucae
BGC0000894.4	0.50	other (other)	citrinin	Monascus aurantiacus
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000671.3	0.43	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001050.5	0.42	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0000204.5	0.42	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001844.4	0.42	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454
BGC0000248.5	0.42	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001240.4	0.55	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.55	NRPS	peramine	Epichloe festucae
BGC0000894.4	0.50	other (other)	citrinin	Monascus aurantiacus
BGC0001197.5	0.44	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000671.3	0.43	terpene	momilactone B	Oryza sativa Japonica Group
BGC0001050.5	0.42	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0000204.5	0.42	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001844.4	0.42	NRPS	holrhizin A, holrhizin B, holrhizin C, holrhizin D	Paraburkholderia rhizoxinica HKI 454
BGC0000248.5	0.42	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

Additional weak hits (3):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.82 out of 28.14

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.99 out of 26.33

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.71 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_JAHTMR010000003.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 120,251 - 131,438 nt. (total: 11,188 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.25	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.25	ribosomal	nisin U	Streptococcus uberis
BGC0002694.2	0.22	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0001515.4	0.22	NRPS	aspercryptins	Aspergillus nidulans FGSC A4
BGC0001148.5	0.21	NRPS, ribosomal	pheganomycin	Streptomyces cirratus
BGC0002408.3	0.19	NRPS	malleobactin X	Collimonas pratensis
BGC0002131.4	0.19	NRPS, PKS, saccharide	aurantoside A	Chloroflexi bacterium TSY

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.25	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.25	ribosomal	nisin U	Streptococcus uberis
BGC0002694.2	0.22	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0001515.4	0.22	NRPS	aspercryptins	Aspergillus nidulans FGSC A4
BGC0001148.5	0.21	NRPS, ribosomal	pheganomycin	Streptomyces cirratus
BGC0002408.3	0.19	NRPS	malleobactin X	Collimonas pratensis
BGC0002131.4	0.19	NRPS, PKS, saccharide	aurantoside A	Chloroflexi bacterium TSY

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.54 out of 23.79

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.16 out of 26.33

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.75 out of 27.55

Confidence: medium

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.49 out of 30.22

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (1):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.34 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
ClgR	Caseinolytic protease gene regulator
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism

NZ_JAHTMR010000003.1 - Region 2 - betalactone,terpene-precursor

Download region GenBank file

Download region SVG

Location: 387,537 - 419,627 nt. (total: 32,091 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

KUF73_RS09320: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

KUF73_RS09330: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

KUF73_RS09420: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

KUF73_RS09425: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Hydrolases: hydrolase peptidase

KUF73_RS09350: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

KUF73_RS09435: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Lyases: dehydratase hydratase

KUF73_RS09355: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

KUF73_RS09370: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

KUF73_RS09375: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

KUF73_RS09380: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase synthetase

KUF73_RS09345: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

KUF73_RS09385: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

KUF73_RS09395: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Translocases: permease

KUF73_RS09340: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.42	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.37	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.32	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.28	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000252.5	0.28	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000630.3	0.27	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000640.3	0.27	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000632.5	0.27	saccharide, terpene	brasilicardin A	Nocardia terpenica
BGC0000646.5	0.27	terpene	β-carotein	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.50	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.48	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002493.3	0.46	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0002309.2	0.46	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000252.5	0.45	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0002496.3	0.45	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0001659.3	0.44	terpene	mangicol A	Fusarium equiseti
BGC0002487.3	0.44	other (other)	staphylopine	Staphylococcus aureus subsp. aureus Mu50
BGC0001605.3	0.44	terpene	gibberellin	Sinorhizobium fredii NGR234

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

KUF73_RS09345: PT_FPPS_like

Domain 1 (37 - 299): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.26 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.95 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.81 out of 23.79

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.13 out of 24.78

Confidence: medium

Additional weak hits (8):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.78 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.84 out of 25.88

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.96 out of 28.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.53 out of 30.11

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 21.49 out of 36.54

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.17 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 25.06 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.04 out of 29.65

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_JAHTMR010000006.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 74,494 - 95,381 nt. (total: 20,888 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase synthetase

KUF73_RS14165: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

KUF73_RS14170: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001361.3	0.46	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.46	terpene	sodorifen	Serratia plymuthica
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000927.3	0.42	other (flavin)	roseoflavin	Streptomyces davaonensis JCM 4913
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000929.3	0.38	other (other)	xanthothricin	Burkholderia glumae
BGC0001959.4	0.37	other (other)	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002152.2	0.36	other (other)	toxoflavin	Pseudomonas protegens Pf-5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0001361.3	0.46	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002283.2	0.46	terpene	sodorifen	Serratia plymuthica
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000927.3	0.42	other (flavin)	roseoflavin	Streptomyces davaonensis JCM 4913
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000929.3	0.38	other (other)	xanthothricin	Burkholderia glumae
BGC0001959.4	0.37	other (other)	taylorflavin A, taylorflavin B	Streptomyces hiroshimensis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002152.2	0.36	other (other)	toxoflavin	Pseudomonas protegens Pf-5

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

KUF73_RS14170: PT_FPPS_like

Domain 1 (31 - 294): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.19 out of 20.47

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 21.40 out of 23.05

Confidence: strong

Additional weak hits (7):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.94 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.86 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.54 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.24 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.22 out of 26.06

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.87 out of 36.53

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.55 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
AfsR	Pleiotropic regulatory for antibiotic production
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAHTMR010000006.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 199,209 - 222,289 nt. (total: 23,081 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

KUF73_RS14755: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

KUF73_RS14785: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: synthase

KUF73_RS14745: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	0.42	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001077.4	0.41	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000502.5	0.39	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000595.3	0.36	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000999.4	0.33	NRPS, PKS	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0002362.3	0.32	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0001127.5	0.30	NRPS	jagaricin	Janthinobacterium agaricidamnosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000516.4	0.42	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001077.4	0.41	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000502.5	0.39	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000595.3	0.36	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000999.4	0.33	NRPS, PKS	heat-stable antifungal factor	Lysobacter enzymogenes
BGC0002362.3	0.32	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0001127.5	0.30	NRPS	jagaricin	Janthinobacterium agaricidamnosum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KUF73_RS14755

KUF73_RS14750

Leader:

MQEQIMDLSGELDAEFEA

Core:

YVNSGSAGAKGGEVMCTMLSCETLGCTVLGCC

Core with dehydrations:

YVNDhaGDhaAGAKGGEVMCysDhbMLDhaCysEDhbLGCysDhbVLGCysCys

antiSMASH-DB 4.0 matches for KUF73_RS14750

100.0%

NZ_JAHTMR010000006.1:

Lanthipeptides: KUF73_RS14750_lanthipeptide

1

YVNSGSAGAKGGEVMCTMLSCETLGCTVLGCC

32

YVNSGSAGAKGGEVMCTMLSCETLGCTVLGCC

1

YVNSGSAGAKGGEVMCTMLSCETLGCTVLGCC

32

62.5%

NZ_FYDO01000006.1:

Lanthipeptides: CKW19_RS28830_lanthipeptide

1

YVNSGSAGAKGGEVMCTMLSCETLGCTVLGC

31

YV++G A GGE MCT +SC TL CTVLGC

1

YVSAGQADV-GGETMCTNMSCGTLSCTVLGC

30

59.4%

NZ_JSAK01000013.1:

Lanthipeptides: NL64_RS30110_lanthipeptide

1

YVNSGSAGAKGGEVMCTMLSCETLGCTVLGC

31

YV++ A GGE MCT +SC TL CTVLGC

1

YVSAADANV-GGEGMCTNMSCGTLHCTVLGC

30

with 15 more sequence matches

Only the first 10 are displayed here.

47.4%

NZ_NEHJ01000011.1:

Lanthipeptides: CAG02_RS29890_lanthipeptide

1

YVNSGSAGAKGGEVMC-TMLSCETLGCTVLGCC

32

Y+NSG A EV C T +SC TL CT +GCC

5

YMNSGRALVVA-EVGCETTVSCSTLACTFMGCC

36

45.7%

NZ_FYDR01000007.1:

Lanthipeptides: CKW11_RS28580_lanthipeptide

1

YVNSGSAGAKGGEVMCTM-LSCETLGCTVLGC

31

YV +G G EVM T ++CE+LGCT GC

5

YVKAGVNKMAGVEVMATTAITCESLGCT-FGC

35

41.0%

NZ_CABVIY010000009.1:

Lanthipeptides: F8N66_RS31570_lanthipeptide

1

YVNSGSAGAKGGEVMC-TMLSCETLGCTVLGCC

32

YVNSG+A E+ C T + C T+ CTVL C

5

YVNSGNADV-AAEIGCDTTVGCPTVACTVLQPC

36

40.6%

NZ_CP028826.1:

Lanthipeptides: DBV33_RS28695_lanthipeptide

15

MCTMLSCETLGCTVLGCC

32

MCT++ C TLGCTVL CC

3

MCTVIQCGTLGCTVLACC

20

37.5%

NZ_KN639174.1and 1 other:

NZ_LT629746.1 Lanthipeptides: BLU65_RS30130_lanthipeptide

Lanthipeptides: AW34_RS30740_lanthipeptide

11

GGEVMCTM-LSCETLGCTVL

29

G EVM T ++CE+LGCTV

6

GVEVMSTTAITCESLGCTVF

25

31.2%

NZ_CP023466.1and 2 others:

NZ_JHVT01000005.1 Lanthipeptides: N519_RS1000000131445_lanthipeptideNZ_KB906329.1 Lanthipeptides: F626_RS1000000132200_lanthipeptide

Lanthipeptides: CNN82_RS30460_lanthipeptide

17

TMLSCETLGCTVLGC

31

T+L C TL CT LGC

3

TILDCGTLQCTGLGC

17

25.0%

NZ_FMTK01000030.1and 6 others:

NZ_FMUZ01000022.1 Lanthipeptides: BLP82_RS31220_lanthipeptideNZ_FMXV01000022.1 Lanthipeptides: BLQ55_RS32250_lanthipeptideNZ_FOKH01000030.1 Lanthipeptides: BM321_RS30595_lanthipeptideNZ_FOVS01000023.1 Lanthipeptides: BM317_RS30755_lanthipeptideNZ_FPJC01000031.1 Lanthipeptides: BT125_RS29520_lanthipeptideNZ_SMCJ01000020.1 Lanthipeptides: EDB98_RS30925_lanthipeptide

Lanthipeptides: BLO80_RS30030_lanthipeptide

16

CTMLSCETLGC

26

CT L C TLGC

10

CTNLECSTLGC

20

25.0%

NZ_FMXV01000022.1:

Lanthipeptides: BLQ55_RS32255_lanthipeptide

17

TMLSCETLGCTVLGC

31

T++ C TL CT L C

2

TIVECGTLNCTALLC

16

21.9%

NZ_AP023392.1and 3 others:

NZ_CP015557.1 Lanthipeptides: allorf_0959937_0960152_lanthipeptideNZ_CP100430.1 Lanthipeptides: allorf_0947658_0947873_lanthipeptideNZ_JAEUXF010000003.1 Lanthipeptides: allorf_104571_104786_lanthipeptide

Lanthipeptides: allorf_0997002_0997217_lanthipeptide

12

GEVMCTMLSCETLGCT

27

GE++ +L CE +G T

1

GELVIRILLCEAVGPT

16

21.9%

NZ_CP048607.1and 2 others:

NZ_CP097108.1 Lanthipeptides: M3M50_RS26390_lanthipeptideNZ_JAJQKS010000013.1 Lanthipeptides: LT249_RS28345_lanthipeptide

Lanthipeptides: allorf_4196740_4196883_lanthipeptide

17

TMLSCETLGCTVLGC

31

T++ C T+GCT + C

6

TIVECGTIGCTAILC

20

MIBiG 4.0 matches for KUF73_RS14750

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

6

SAGAKGGEVM

15

+ G K G +M

8

TPGCKTGALM

17

10.8%

BGC0001229.4 (SBI_06989)and 1 other:

BGC0002110.3 (QKV49894.1) Lanthipeptide: birimositide

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CETLGCT

27

C T CT

28

CPTTKCT

34

allorf_202655_202816

Leader:

MLWAFDHFAIVAIGA

Core:

FSCSGGTVLVANEQPPRFALMISMTIPIRKELTLYKGL

Core with dehydrations:

FDhaCysDhaGGDhbVLVANEQPPRFALMIDhaMDhbIPIRKELDhbLYKGL

antiSMASH-DB 4.0 matches for allorf_202655_202816

100.0%

NZ_JAHTMR010000006.1:

Lanthipeptides: allorf_202655_202816_lanthipeptide

1

FSCSGGTVLVANEQPPRFALMISMTIPIRKELTLYKGL

38

FSCSGGTVLVANEQPPRFALMISMTIPIRKELTLYKGL

1

FSCSGGTVLVANEQPPRFALMISMTIPIRKELTLYKGL

38

14.6%

NZ_FWXV01000006.1:

Lanthipeptides: B9C43_RS31420_lanthipeptide

2

SCSGGTVLVANEQPPRF

18

SCSG T + Q P +

8

SCSGNTGGAGHHQHPAY

24

MIBiG 4.0 matches for allorf_202655_202816

10.5%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

1

FSCSGGT

7

F C G T

12

FVCDGNT

18

allorf_215120_215242

Leader:

MGGILVGVLAA

Core:

GAQSASASGFNYCGLTGMSSAGAVYARFF

Core with dehydrations:

GAQDhaADhaADhaGFNYCysGLDhbGMDhaDhaAGAVYARFF

antiSMASH-DB 4.0 matches for allorf_215120_215242

100.0%

NZ_JAHTMR010000006.1:

Lanthipeptides: allorf_215120_215242_lanthipeptide

1

GAQSASASGFNYCGLTGMSSAGAVYARFF

29

GAQSASASGFNYCGLTGMSSAGAVYARFF

1

GAQSASASGFNYCGLTGMSSAGAVYARFF

29

51.7%

NZ_CP012831.1and 3 others:

NZ_CP072913.1 Lanthipeptides: allorf_5794222_5794335_lanthipeptideNZ_FPJC01000031.1 Lanthipeptides: allorf_04653_04760_lanthipeptideNZ_SMCJ01000020.1 Lanthipeptides: allorf_004032_004139_lanthipeptide

Lanthipeptides: allorf_3557076_3557183_lanthipeptide

7

ASGFNYCGLTGMSSAGAV

24

ASG +YCGLTG+SSAGAV

9

ASGLHYCGLTGLSSAGAV

26

24.1%

NZ_CP047146.1:

Lassopeptides: GR130_RS08740_lassopeptide

12

YCGLTGMSSAGAVYAR

27

Y GLTG + Y R

1

YFGLTGYENLFHFYDR

16

with 1 more sequence matches

17.6%

NZ_KV793075.1:

Lanthipeptides: HMPREF3164_RS11370_lanthipeptide

1

GAQSASASGFNYCGLTGMS

19

G +A+ +YCG+T ++

16

GVVGLAATYDDYCGMTDLT

34

allorf_217573_217683

Leader:

MAYETASCRRQVVFM

Core:

VGVRAKRSQPSAAPTLECVLL

Core with dehydrations:

VGVRAKRDhaQPDhaAAPDhbLECysVLL

antiSMASH-DB 4.0 matches for allorf_217573_217683

100.0%

NZ_JAHTMR010000006.1:

Lanthipeptides: allorf_217573_217683_lanthipeptide

1

VGVRAKRSQPSAAPTLECVLL

21

VGVRAKRSQPSAAPTLECVLL

1

VGVRAKRSQPSAAPTLECVLL

21

34.8%

NZ_JACHJJ010000004.1:

Lanthipeptides: FHS22_RS08745_lanthipeptide

4

RAKRSQPSAAPTLECVL

20

AK QP+ P L C L

6

EAKAFQPAVVPQLLCAL

22

16.7%

NZ_KB900614.1:

Lanthipeptides: allorf_2951511_2951720_lanthipeptide

4

RAKRSQPSAAPTLEC

18

R++R PS TL+C

5

RSQRWCPSCGDTLDC

19

with 1 more sequence matches

14.5%

NZ_CP031087.1:

Lanthipeptides: allorf_5845048_5845257_lanthipeptide

2

GVRAKRSQPSAAP

14

G RA R+ PS+AP

24

GTRALRATPSSAP

36

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.35 out of 18.57

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.54 out of 23.79

Confidence: strong

Additional weak hits (7):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.24 out of 28.14

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.38 out of 21.55

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.81 out of 32.74

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.32 out of 30.22

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.42 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.51 out of 26.06

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

KUF73_RS14750 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3035.3 Da

Molecular weight: 3037.6 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3055.6 Da N = 1

allorf_202655_202816 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 4072.2 Da

Molecular weight: 4074.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4092.9 Da N = 1; 4110.9 Da N = 2; 4128.9 Da N = 3; 4146.9 Da N = 4; 4164.9 Da N = 5

allorf_215120_215242 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 2769.3 Da

Molecular weight: 2771.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2789.0 Da N = 1; 2807.1 Da N = 2; 2825.1 Da N = 3; 2843.1 Da N = 4; 2861.1 Da N = 5

allorf_217573_217683 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 2140.2 Da

Molecular weight: 2141.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2159.5 Da N = 1; 2177.6 Da N = 2

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JAHTMR010000007.1 - Region 1 - arylpolyene

Download region GenBank file

Download region SVG

Location: 86,486 - 130,103 nt. (total: 43,618 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

KUF73_RS15760: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

KUF73_RS15865: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Transferases: acyltransferase halogenase methyltransferase

KUF73_RS15675: acyltransferase

smcogs: SMCOG1141: acyltransferase

KUF73_RS15735: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

KUF73_RS15740: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: ligase synthase

KUF73_RS15695: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

KUF73_RS15700: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

KUF73_RS15750: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

KUF73_RS15765: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.75	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000836.5	0.60	other (other)	APE Ec	Escherichia coli CFT073
BGC0002008.3	0.59	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001197.5	0.49	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001987.2	0.48	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001940.3	0.48	PKS	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0002711.2	0.48	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001366.5	0.47	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0002608.2	0.75	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0000836.5	0.60	other (other)	APE Ec	Escherichia coli CFT073
BGC0002008.3	0.59	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0001258.3	0.56	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001197.5	0.49	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001987.2	0.48	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001940.3	0.48	PKS	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0002711.2	0.48	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001366.5	0.47	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.92 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.79 out of 20.97

Confidence: medium

Additional weak hits (10):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.41 out of 29.38

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.91 out of 36.54

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.00 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.51 out of 29.38

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.17 out of 25.88

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.96 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.00 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.53 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.92 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.19 out of 28.19

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

KUF73_RS15695: X

AMP-binding (26..278): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: EALAIYGLLFRWVAFSSGGTEIFGSSETGGIAWR
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism

NZ_JAHTMR010000008.1 - Region 1 - NRPS-like

Download region GenBank file

Download region SVG

Location: 62,574 - 105,402 nt. (total: 42,829 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

KUF73_RS16930: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

KUF73_RS16935: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Lyases: cyclase

KUF73_RS17015: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: ligase

KUF73_RS17010: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

KUF73_RS16975: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000342.4	0.59	NRPS	enniatin	Fusarium equiseti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0000357.5	0.60	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001261.3	0.59	NRPS	AM-toxin	Alternaria alternata
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000342.4	0.59	NRPS	enniatin	Fusarium equiseti

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.81 out of 18.57

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 20.76 out of 21.84

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.31 out of 20.97

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.09 out of 21.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 28.19

Confidence: medium

Additional weak hits (16):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.50 out of 26.33

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.24 out of 21.55

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 22.00 out of 32.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.53 out of 32.74

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.64 out of 18.57

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.45 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.17 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.54 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.80 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.43 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.04 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.55 out of 28.19

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.62 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 62573 - 105402:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

KUF73_RS17010: X

AMP-binding (23..435): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FWHSHDPVYRDTHLFWGGDVNFYGTTETPQAMAY
Nearest Stachelhaus code(s):: Aad DPRHFVMRAK (68% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor