LOCUS       NZ_JAHTMR010000009     23246 bp    DNA     linear   CON 21-AUG-2024
DEFINITION  Pseudomonas sp. PD9R Contig_10_consensus_sequence, whole genome
            shotgun sequence.
ACCESSION   NZ_JAHTMR010000009
VERSION     NZ_JAHTMR010000009.1
KEYWORDS    WGS; RefSeq.
SOURCE      Pseudomonas sp. PD9R
  ORGANISM  Pseudomonas sp. PD9R
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
            Pseudomonadaceae; Pseudomonas.
REFERENCE   1  (bases 1 to 267395)
  AUTHORS   Tournay,R., Firrincieli,A., Parikh,S. and Dominic,S.
  TITLE     Isolation and characterization of arsenic-tolerant endophytes and
            the potential of endophytic biofilms in arsenic tolerance
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 267395)
  AUTHORS   Tournay,R., Firrincieli,A. and Doty,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2021) School of Environmental and Forest Sciences,
            University of Washington, 4000 15th Ave NE, Seattle, WA 98195, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 23-JAN-2020
            Assembly Method                   :: Geneious Prime v. 2020.0.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 158.0x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019200975.1-RS_2024_08_21
            Annotation Date                   :: 08/21/2024 05:49:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,297
            CDSs (total)                      :: 6,222
            Genes (coding)                    :: 6,093
            CDSs (with protein)               :: 6,093
            Genes (RNA)                       :: 75
            rRNAs                             :: 6, 1, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 61
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 129
            CDSs (without protein)            :: 129
            Pseudo Genes (ambiguous residues) :: 2 of 129
            Pseudo Genes (frameshifted)       :: 24 of 129
            Pseudo Genes (incomplete)         :: 110 of 129
            Pseudo Genes (internal stop)      :: 10 of 129
            Pseudo Genes (multiple problems)  :: 15 of 129
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:28:33
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 26241
            Orig. end                         :: 49487
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHTMR010000009.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23246
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..23246
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23246
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:13246]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13246
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            762..2372
                     /locus_tag="KUF73_RS18005"
                     /old_locus_tag="KUF73_18010"
     CDS             762..2372
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1274: gamma-glutamyltranspeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015884887.1"
                     /locus_tag="KUF73_RS18005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18010"
                     /product="gamma-glutamyltransferase family protein"
                     /protein_id="WP_218439408.1"
                     /transl_table=11
                     /translation="MFKFSAHEYPYASQRQSVFAKRGMVAASQPLAAEAGIEIMRRGGN
                     AIDAAIATAAALTVVEPTGCGIGGDAFALVWTQNKLHGLNANGAAPQALSIEAVKAAGY
                     EKMPLHGWTPVTVPGCPSAWAELSRRFGRLPFADLLQPAISLARDGFPVSPVVALQWQT
                     ALEDFTPDRSDVLESWFDTFLIDGRAPRAGELFRNPAQARTLSELANTGCESLYRGALA
                     QRLDAHSRATGGYLRASDLQDYRAQWVEPIKVNYRGVDVWEIPPSGQGLVALMTLKMLE
                     GFDFDHRDSQQTWHRQLEAMKLAYSDGLHYITDPEHMRVAVDDLLSDHYAAHRRAQIGE
                     QAVAPQPGDPHASGTVYLATADAEGNMVSFIQSNYHGFGSGVVLPDSGIALQNRGEEFS
                     LDPEHANCLAPGKKTFHTIIPGFLSKDGVAMGPFGVMGGYMQPQGHVQMVMNLVDFGLN
                     PQAALDAPRWQWLGGLKVGIEQNASRDMAAALARRGHEVQVVCDLTSYGRGQIILRDPE
                     TGVLCGGTEPRADSHIAVY"
     gene            complement(2877..3218)
                     /locus_tag="KUF73_RS18010"
                     /old_locus_tag="KUF73_18015"
     CDS             complement(2877..3218)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007999522.1"
                     /locus_tag="KUF73_RS18010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18015"
                     /product="DUF6124 family protein"
                     /protein_id="WP_218439409.1"
                     /transl_table=11
                     /translation="MNQPVNDLPDMQIDTSLTSPQGSAAAQRALDYYLKPAVSEEGVEE
                     RFFDVNRNISCEEALVHASDLLRCAAATAHESANHLQGASRDLAFSTVHMIDMAKAMVD
                     RSLEGHQNG"
     gene            3348..3986
                     /locus_tag="KUF73_RS18015"
                     /old_locus_tag="KUF73_18020"
     CDS             3348..3986
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019580039.1"
                     /locus_tag="KUF73_RS18015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18020"
                     /product="LexA family transcriptional regulator"
                     /protein_id="WP_218439410.1"
                     /transl_table=11
                     /translation="MDKWIELVKAKMSELKVTQEILAERLGMSQGGIGHWLTKRRQPGI
                     DDMNRVLHALGLGFLEVALVIREPLDSQDDEISLTQKYNPYFRYPVSDWRETSEVRDGE
                     QAQYRFELSDYHAQGAAFWLTVAGDAMTAPTGLSIAEGMLILVDPDVEAEPGKLVIAQW
                     PSSSEAIFRKLIEEGGQRYLVPLNPTYPKALFTEECRIIGVVVQATAKF"
     gene            complement(4026..5981)
                     /locus_tag="KUF73_RS18020"
                     /old_locus_tag="KUF73_18025"
     CDS             complement(4026..5981)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007981007.1"
                     /locus_tag="KUF73_RS18020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18025"
                     /product="acetyl/propionyl/methylcrotonyl-CoA carboxylase
                     subunit alpha"
                     /protein_id="WP_218439411.1"
                     /sec_met_domain="ATP-grasp (E-value: 1.3e-11, bitscore:
                     38.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.6e-14,
                     bitscore: 46.3, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPVLTTLLVANRGEIACRVMRTAKALGLTTVAVHSATDRDARH
                     SREADIRVDLGGSKAAESYLQIDKLIAAAKASGAQAIHPGYGFLSENAGFARAIEAAGL
                     IFLGPPASAIDAMGSKSAAKALMETAGVPLVPGYHGEAQDLDTFRAACERIGYPVLLKA
                     TAGGGGKGMKVVEDVSQLAEALASAQREALSSFGDSRMLVEKYLLQPRHVEIQVFADQH
                     GNCLYLNERDCSIQRRHQKVVEEAPAPGLSPQLRRAMGEAAVRSAQAIGYVGAGTVEFL
                     LDARGEFFFMEMNTRLQVEHPVTEAITGLDLVAWQIRVARGEALPMTQEQVPLIGHAIE
                     VRLYAEDPGNDFLPATGRLELYRESAQGPGRRVDSGVEEGDDISPFYDPMLGKLIAWGE
                     DREQARLRLLSMLDEFAIGGLKTNINFLRRIIGHPAFAAAELDTGFIPRYQEQLLPPPA
                     ALSDEFWQAAAQAFAQSQPHSFRADDLSSPWANSNGFRAGLPTEITLHLSCEGQDRALT
                     LGNLNIQTAQLKGEQLLTEHDGVRRQHRAIRRGAGVYLQWEGELRRIESYDPISAVEAS
                     HSHQGGLTAPMNGSIVRVLVEAGQAVEAGAQLVVLEAMKMEHSIRAPHAGVIKALYCQE
                     GEMVSEGSALVELEEA"
     gene            complement(5981..6796)
                     /locus_tag="KUF73_RS18025"
                     /old_locus_tag="KUF73_18030"
     CDS             complement(5981..6796)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (15-255). E-value: 9.2e-46. Score:
                     148.1. Matches aSDomain:
                     nrpspksdomains_KUF73_RS18025_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010458779.1"
                     /locus_tag="KUF73_RS18025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18030"
                     /product="gamma-carboxygeranoyl-CoA hydratase"
                     /protein_id="WP_218439412.1"
                     /transl_table=11
                     /translation="MSDFNTLELQTDPRGFATLWLSREEKNNAFNAEMIRELIIAMDKV
                     ASDASLRFLLVRGRGKHFSAGADLAWMQQSAELDYHTNLDDARELAELMYNLAKLKVPT
                     LAVVQGAAFGGALGLISCCDMAIGADEAQFCLSEVRIGLAPAVISPFVVQAIGERAARR
                     YALTAERFGGQRAREIGLLSESYPSSELEQNVEQWIDNLLLNSPAAMRASKDLLREVGD
                     GSLTPSLRRYTENAIARIRVSPEGQEGLRAFLQKRPPSWQDETTTKEPR"
     aSDomain        complement(6032..6751)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KUF73_RS18025_ECH.1"
                     /evalue="9.20E-46"
                     /label="KUF73_RS18025_ECH.1"
                     /locus_tag="KUF73_RS18025"
                     /protein_end="255"
                     /protein_start="15"
                     /score="148.1"
                     /tool="antismash"
                     /translation="FATLWLSREEKNNAFNAEMIRELIIAMDKVASDASLRFLLVRGRG
                     KHFSAGADLAWMQQSAELDYHTNLDDARELAELMYNLAKLKVPTLAVVQGAAFGGALGL
                     ISCCDMAIGADEAQFCLSEVRIGLAPAVISPFVVQAIGERAARRYALTAERFGGQRARE
                     IGLLSESYPSSELEQNVEQWIDNLLLNSPAAMRASKDLLREVGDGSLTPSLRRYTENAI
                     ARIRVSPEGQEGLRAFLQ"
     misc_feature    complement(6901..6917)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.39"
                     /tool="antismash"
     gene            complement(6912..8519)
                     /locus_tag="KUF73_RS18030"
                     /old_locus_tag="KUF73_18035"
     CDS             complement(6912..8519)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_250704.1"
                     /locus_tag="KUF73_RS18030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18035"
                     /product="carboxyl transferase domain-containing protein"
                     /protein_id="WP_218439413.1"
                     /transl_table=11
                     /translation="MAILHTQLNPRSAEFAANSAAMLKQVDALHTLLAQVAQGGGPKAQ
                     ERHTSRGKLLPRERINRLLDPGSPFLEISQLAAYEVYGEDVPAAGVIAGIGRVEGVECM
                     IVANDATVKGGSYYPLTVKKHLRAQTIAQQNRLPCIYLVDSGGANLPRQDEVFPDREHF
                     GRIFFNQANMSAMGIPQIAVVMGSCTAGGAYVPAMADEAIMVREQATIFLAGPPLVKAA
                     TGEVVSAEDLGGADVHCKISGVADHYAESDEHALAIARRSVANLNWRKLGELQQRTPIA
                     PLYNSDELYGVVPADAKQPFDVREVIARLVDGSVFDEFKALFGTTLVCGFSYLHGYPIA
                     ILANNGILFAEAAQKGAHFIELACQRGIPLLFLQNITGFMVGQKYEAGGIAKHGAKLVT
                     AVACAKVPKFTVIIGGSFGAGNYGMCGRAYDPRFLWMWPNARIGVMGAEQAAGVLVQVK
                     REQAERSGQGFSAEQEADIKQPILDQYEEQGHPYYSSARLWDDGVIDPAQTRDVLGLAL
                     SASLNAPIEPSRFGVFRM"
     gene            complement(8532..9695)
                     /locus_tag="KUF73_RS18035"
                     /old_locus_tag="KUF73_18040"
     CDS             complement(8532..9695)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_250705.1"
                     /locus_tag="KUF73_RS18035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18040"
                     /product="isovaleryl-CoA dehydrogenase"
                     /protein_id="WP_218439414.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 4.7e-40, bitscore:
                     130.8, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.8e-29, bitscore:
                     95.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.2e-43, bitscore:
                     140.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYPSLNFALGETIDMLRDQVQSFVAKEIAPRAAQIDIDNLFPAD
                     LWRKFGDMGLLGVTVPEEYGGAGLGYLAHVVAMEEISRGSASVALSYGAHSNLCVNQIN
                     RNGNHEQKTKYLPKLISGEHIGALAMSEPNAGSDVVSMKLRADKRGDRYVLNGSKTWIT
                     NGPDANTYVIYAKTDLEKGPHGITAFIVERDWKGFSRSNKFDKLGMRGSNTCELFFDDV
                     EVPEENILGVLNGGVKVLMSGLDYERVVLSGGPTGIMQACMDLIVPYIHDRKQFGQSIG
                     EFQLIQGKVADMYTQLNASRAYLYAVAQACERGETTRKDAAGVILYSAERATQMALDAI
                     QILGGNGYINEFPAGRLLRDAKLYEIGAGTSEIRRMLIGRELFNETR"
     misc_feature    9772..9790
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     misc_feature    9889..9898
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.8"
                     /tool="antismash"
     misc_feature    9900..9914
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 18.29"
                     /tool="antismash"
     gene            10001..11695
                     /locus_tag="KUF73_RS18040"
                     /old_locus_tag="KUF73_18045"
     CDS             10001..11695
                     /NRPS_PKS="Domain: AMP-binding (29-462). E-value: 3.9e-98.
                     Score: 320.6. Matches aSDomain:
                     nrpspksdomains_KUF73_RS18040_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007980998.1"
                     /locus_tag="KUF73_RS18040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18045"
                     /product="AMP-binding protein"
                     /protein_id="WP_218439415.1"
                     /sec_met_domain="AMP-binding (E-value: 1e-106, bitscore:
                     350.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQPSVNPQRSYTRGSQDKALLAMTIGQAFDNTVAQHPNGEALVV
                     RHQQLRYTWRQLADAADLHARALLALGLQTGDRLGIWAPNCAQWCISQIASAKIGVILV
                     NINPAYRSSELEYVLKQSGCQWLVCAGAFKTSNYHVMVQGLVPELAQQSIGKLHSERLP
                     ELRGVISLDAQPPVGFLPWSQLADLAGSVSVEQLHERQGSLHFDQAVNIQYTSGTTGFP
                     KGATLSHYNILNNGYMVGESLGLTAADRLVIPVPLYHCFGMVMGNLGCITHGSTMIYPN
                     DAFDPLLTLNTVVEEKATALYGVPTMFIAMLDQPQRAEFDLSSLRTGIMAGATCPIEVM
                     RRVISEMHMSEVQIAYGMTETSPVSLQTGPSDDLELRVTTVGRTQPQLESKIIDEAGNL
                     VPRGTIGELCTRGYSVMLGYWKNPEGTAEAIDQAGWMHTGDLASMNDEGYVCIAGRNKD
                     MIIRGGENVYPRELEEFFFTHPAVADVQVIGIPCSRYGEEIVAWIKFHPGHSATEQELQ
                     TWCKERIAHFKTPRYFKFVEEFPMTVTGKIQKFRMREISIEDLKASR"
     aSDomain        10088..11386
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KUF73_RS18040_AMP-binding.1"
                     /evalue="3.90E-98"
                     /label="KUF73_RS18040_AMP-binding.1"
                     /locus_tag="KUF73_RS18040"
                     /protein_end="462"
                     /protein_start="29"
                     /score="320.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FDNTVAQHPNGEALVVRHQQLRYTWRQLADAADLHARALLALGLQ
                     TGDRLGIWAPNCAQWCISQIASAKIGVILVNINPAYRSSELEYVLKQSGCQWLVCAGAF
                     KTSNYHVMVQGLVPELAQQSIGKLHSERLPELRGVISLDAQPPVGFLPWSQLADLAGSV
                     SVEQLHERQGSLHFDQAVNIQYTSGTTGFPKGATLSHYNILNNGYMVGESLGLTAADRL
                     VIPVPLYHCFGMVMGNLGCITHGSTMIYPNDAFDPLLTLNTVVEEKATALYGVPTMFIA
                     MLDQPQRAEFDLSSLRTGIMAGATCPIEVMRRVISEMHMSEVQIAYGMTETSPVSLQTG
                     PSDDLELRVTTVGRTQPQLESKIIDEAGNLVPRGTIGELCTRGYSVMLGYWKNPEGTAE
                     AIDQAGWMHTGDLASMNDEGYVCIAGRNKDMIIR"
     CDS_motif       10634..10687
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KUF73_RS18040_0001"
                     /evalue="1.30E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="KUF73_RS18040"
                     /protein_end="229"
                     /protein_start="211"
                     /score="17.9"
                     /tool="antismash"
                     /translation="IQYTSGTTGFPKGATLSH"
     CDS_motif       11201..11287
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KUF73_RS18040_0002"
                     /evalue="5.50E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="KUF73_RS18040"
                     /protein_end="429"
                     /protein_start="400"
                     /score="28.3"
                     /tool="antismash"
                     /translation="PRGTIGELCTRGYSVMLGYWKNPEGTAEA"
     gene            complement(12347..13246)
                     /locus_tag="KUF73_RS18045"
                     /old_locus_tag="KUF73_18050"
     CDS             complement(12347..13246)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015094354.1"
                     /locus_tag="KUF73_RS18045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18050"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_218439416.1"
                     /sec_met_domain="HMGL-like (E-value: 1.5e-54, bitscore:
                     179.2, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLPTKVRLVEVGPRDGLQNEAQPISVADKVQLVDALTAAGLGYI
                     EVGSFVSPKWVPQMAGSAEVFAQIQRKPGVTYGALAPNLRGFEDALASGVKEVAVFAAA
                     SEAFSQRNINCSISESLERFVPIMDAAKQHGVSVRGYVSCVLGCPYEGNVTPEQVAHVA
                     RELYAMGCYEVSLGDTIGTGTAGATRKMFDVVSAVVPRDKLAGHFHDTYGQAMANIYAS
                     LLEGISVFDSSIAGLGGCPYAKGASGNVATEDVVYLLNGLGIETGINLDTLILAGQQIC
                     SVLGRPTGSRVAKARSAQ"
     gene            complement(13394..13795)
                     /locus_tag="KUF73_RS18050"
                     /old_locus_tag="KUF73_18055"
     CDS             complement(13394..13795)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003200000.1"
                     /locus_tag="KUF73_RS18050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18055"
                     /product="MerR family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_218439417.1"
                     /transl_table=11
                     /translation="MSSQTYSISDLARELDITTRAIRFYEEQGLLSPERRGQERIYSPR
                     DKVSLKLILRGKRIGFSLAECRELIELYDPTGGNQKQLQTMLTKIAERREQLEQQMLDI
                     EQMKLELDTAQERCIQALEQTIKSQEVIQ"
     misc_feature    complement(13794..13808)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.51"
                     /tool="antismash"
     misc_feature    13795..13809
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.54"
                     /tool="antismash"
     misc_feature    13827..13847
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.09"
                     /tool="antismash"
     misc_feature    complement(13920..13933)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 22.67"
                     /tool="antismash"
     gene            complement(13930..14865)
                     /locus_tag="KUF73_RS18055"
                     /old_locus_tag="KUF73_18060"
     CDS             complement(13930..14865)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1125: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007917233.1"
                     /locus_tag="KUF73_RS18055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18060"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_218439418.1"
                     /transl_table=11
                     /translation="MNLSKVDLNLFIVFDAIYTEANLTRAGQIVGITQPAVSNALARLR
                     ETFNDPLFVRTAQGMVPTPMAQNIIGPVRNALSLLRVSVQESRIFNPLQAVKTYRISMT
                     DLTEAVILPPLFQRLRRLAPTVIIESFLSKRRETTKELAAGRLDFAVDAPLNTDPQVRH
                     VKLMEDRYVCAMRKGHPLAGKEKFTLDDYLGLTHIHISSRRSGLGHVDLALGKMGIQRK
                     IALRSQHYLMASQVLQQTDMVMTVPERFARRNDLHAFSLPVNDVPPVETHLYWHESTDQ
                     DPANRWMREQMIELCQQVTAHEKKLDKQVV"
     gene            15054..16283
                     /locus_tag="KUF73_RS18060"
                     /old_locus_tag="KUF73_18065"
     CDS             15054..16283
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009044614.1"
                     /locus_tag="KUF73_RS18060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18065"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_218439419.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.4e-19, bitscore:
                     64.1, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 8e-21, bitscore:
                     68.1, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.3e-34, bitscore:
                     113.6, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFAYSPKVQQLRERVTAFMDTYVYPAEAVFERQVAEGDRWQPTA
                     IMEELKLKAKAEGLWNLFLPESELGAGLTNLEYAPLAEIMGRSLLGPEPFNCSAPDTGN
                     MEVLVRYANEEQKQRWLEPLLRGEIRSAFAMTEPDVASSDATNMAARAVRDGDEWVING
                     KKWWTSGACDPRCKILIFMGLSNPDAPRHAQHSMILVPVDTPGVKIVRPLPVFGYDDAP
                     HGHAEVLFENVRVPYENVLLGEGRGFEIAQGRLGPGRIHHCMRSIGMAERALELMCKRS
                     VNRTAFGKPLARLGGNIDKIADSRMEIDMARLLTLKAAYMMDTVGNKVAKSEIAQIKVV
                     APNVALRVIDRAIQIHGGAGVSNDFPLAYMYAMQRTLRLADGPDEVHRAAIGKFEIGKY
                     VPKEMMRSSH"
     gene            complement(16397..17737)
                     /locus_tag="KUF73_RS18065"
                     /old_locus_tag="KUF73_18070"
     CDS             complement(16397..17737)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019648445.1"
                     /locus_tag="KUF73_RS18065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18070"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_218439420.1"
                     /transl_table=11
                     /translation="MTLRVLFLLMLCNWLPQMAAASGLPVPDHGPVLRIQGSNTIGAAL
                     GPALVEGLLREQGLLKVHSEAPDKANELRIVGETLQGRRVEVELAAHGSSTGFTALKTA
                     NADLAASSRPIKDSEVVDLQMLGDLKSAGAEQVIAIDGLAIILHPQNPLNQLNTVQLAR
                     IFSGEAKTWEELGGSGGTIHLYARDDQSGTYDTFKELVLSSRGKNLSSAAKRFESSEQL
                     SDAVSLDPQAIGFIGLPYVRQAKAVAIVDGQSQAMLPLNSLIATEDYPLSRRLFFYLPP
                     AGNNPWAEALVAFAQSSQGQAIVAANGFIAQTVQAMAVTPNALMPEGYQALSRHAQRLT
                     VNFRFEEGSASLDNKARQDLSRVLDYIKQHDKTDRQVTLVGFGDAKSDPARADLLSKLR
                     AMAVRRELVKSGVVFREIRGFGAEMPVAANSADEGRIKNRRVEVWVY"
     gene            complement(17936..18748)
                     /gene="xthA"
                     /locus_tag="KUF73_RS18070"
                     /old_locus_tag="KUF73_18075"
     CDS             complement(17936..18748)
                     /EC_number="3.1.11.2"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004519 - endonuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0008311 - double-stranded DNA 3'-5' DNA
                     exonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="xthA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_251235.1"
                     /locus_tag="KUF73_RS18070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18075"
                     /product="exodeoxyribonuclease III"
                     /protein_id="WP_218439421.1"
                     /transl_table=11
                     /translation="MKIVSFNINGLRARPHQLAALIEKHQPDVIGLQETKVHDDQFPLD
                     EVKALGYHVYFHGQKGHYGVALLSRQEPLALHKGFATDEEDAQRRFIWGTFADANGVPV
                     TIMNGYFPQGESRDHPTKFPAKQRFYNDLQQLLETQFKNDQPLVVMGDVNISPEDCDIG
                     IGPDNMKRWLKTGKCSFLPEEREWMARLKNWGLVDSFRHLNPEVADRFSWFDYRSRGFE
                     DEPKRGLRIDVIMASHGLLPRVKDAGVDYELRGMEKPSDHAPIWLELS"
     misc_feature    complement(18999..19014)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.98"
                     /tool="antismash"
     gene            19094..19744
                     /locus_tag="KUF73_RS18075"
                     /old_locus_tag="KUF73_18080"
     CDS             19094..19744
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018925466.1"
                     /locus_tag="KUF73_RS18075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18080"
                     /product="N-acetyltransferase"
                     /protein_id="WP_218439422.1"
                     /transl_table=11
                     /translation="MPETSIAIADIHMLDSGYSREARSLLYQAYRHEPTFGYLFEAERP
                     GYEQRVRATVRELVKQHFLQDLPAIGLLVNDRLIGIALIAPPQRRLGITESWAWRLRMV
                     LSTGFRCTRRYLEYHDAVMACVPSDSVHLLPLLGIHPQFQGKHFGEQLLQAVHNWCAVD
                     EHSQGVVLDTGNPRYLEFYKRQGYEEIGEVAVGPIREHVFFHANPQVVQTATA"
     gene            19821..21548
                     /locus_tag="KUF73_RS18080"
                     /old_locus_tag="KUF73_18085"
     CDS             19821..21548
                     /GO_component="GO:0009279 - cell outer membrane [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007904105.1"
                     /locus_tag="KUF73_RS18080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KUF73_18085"
                     /product="autotransporter assembly complex family protein"
                     /protein_id="WP_218439423.1"
                     /transl_table=11
                     /translation="MKFPGRITSGVLMLISSCAALAQSELDVRIKPSNDELKANIEGYI
                     GSLGDRDEEALLRFSRGAEEQARKAAQALGYYQPQIDSDVKGGKKPRLILTIDPGEPVH
                     LRNVTIRIDGPAASLKSFRLPNDHALKTGAVLNHGHYEDAKRLIQNQASRYGFFNGRFT
                     SSKLSVDPRAGVADIELIYDSGPRYSLGKVSFEGDTPFDEDLLQRMVPFKAGAPYDSEL
                     IAELNQAMQSSGYFESVRVDATPTASKDNVIPVDVKLETRKPRTMGLGLGYSTDVGPRI
                     KANWTRHWVNPQGHSYGWETEVSAPRQNVGVFYDIPLDPPLTDKLRFAGGYQNEEIADK
                     DSLSKLLTLGPEWHSKLPSGWQRVVSLKWQREEYRLGDDSGLSTLLMPGVSYSYLKSDN
                     RIDPHNGYRLQFESKVAKEGLGSDNNLVYGTALVKGLTTVFDKHRFLGRVQVGGSATNG
                     YKSVPPSLRFFAGGDQSVRGYDYQSLSPENNEGDRIGGRYMVTASAEYQYSIAEKWRVA
                     TFVDQGNAFNTLELPNLKTGVGIGIRWVSPVGPIRLDLAHALDDDGGIRLHFSMGPEL"
     misc_feature    22358..22367
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.89"
                     /tool="antismash"
     misc_feature    22882..22898
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.88"
                     /tool="antismash"
ORIGIN
        1 ttcatccgct gtatcaattt gctggaagac attcagtctg ggcagattcg cgttggcggc
       61 cggccgatgg gttatcgcac ccgtgccgat ggcagcctgg cccgtgactc ggagcgcaat
      121 attgcgcgac agcgtcgcga catcggcatg gtgttccagc gcttcaacct gttcccgcac
      181 atgacggcgc tggagaacat tatcgaagcg cccattcagg tgttgggcgt gtctcgcgcc
      241 gcagcattgg agcaggcgcg ggcgttgctc aagcgcgtcg ggttggcgga gaaggcggat
      301 cactatccgt cgatgttgtc cgggggccag cagcagcgcg tggccatcgc ccgcgcgctg
      361 gccatgaagc ctcaggcgat gctgttcgac gaacccacca gtgcgctgga cccggaaacc
      421 gtgggtgagg tgctgcaagt catgaaggag ctggctgagg agggcatgac catggtcgtc
      481 gtcacccatg aaatgggctt tgcccgtgaa gtggccgacc gggtggtggt gctcgatcaa
      541 ggtgaactga tcgagcaagg cccgcccgag cagatcttca gcaacccgag ccatgctcgt
      601 acccgggcgt ttctcagccg cgtgttgtag gcgcgagcct tctcgcgatg gacgttaacg
      661 atgacgcgga cttcctggaa aaacgcggtg cacttgagtc catcgcgagc aggcccgctc
      721 ctacaggttt ttatgaacat ttcttttgtg tgagtcctgc catgttcaaa ttttctgccc
      781 atgagtatcc ctacgcgtca caacgtcaaa gtgtcttcgc caagcgcggc atggtcgccg
      841 cctcacaacc gctggccgcc gaagccggaa ttgaaatcat gcgtcgcggc ggcaatgcca
      901 tcgatgcggc catcgccacg gccgccgcgc tgaccgtggt cgaacccacc ggctgcggca
      961 ttggcggcga cgcctttgcg ttggtctgga cgcaaaacaa actgcacggt ttgaacgcca
     1021 acggcgctgc cccgcaggcg ctgagcatcg aagccgtcaa agcggccggc tacgaaaaga
     1081 tgccattgca tggctggaca ccggtgactg ttccaggttg tccgtcggcc tgggccgagc
     1141 tgtcccggcg tttcggtcgt ctgcctttcg cggacctgtt gcagccagca atcagtctgg
     1201 cgcgggatgg ttttcccgtg tcgccggtgg tcgcgttgca gtggcaaacc gcgctggagg
     1261 atttcacccc cgatcgcagc gatgtgctgg aaagctggtt cgacaccttc ctgattgatg
     1321 gccgcgcacc ccgcgccggt gaactgttcc gcaacccggc ccaggcccgc accttgagcg
     1381 aactggcaaa caccggatgc gagagcctct atcgcggcgc gctggcgcaa cggctggacg
     1441 cgcattcgcg ggccaccggt ggctatctgc gcgccagtga tttgcaggac tatcgcgcgc
     1501 aatgggtcga gccgatcaag gtcaactacc gcggtgtcga tgtctgggag attccgccga
     1561 gcgggcaggg gctcgtggcc ttgatgacgc tgaagatgct ggagggtttc gacttcgatc
     1621 accgtgacag ccagcaaacc tggcaccgtc aactcgaagc gatgaaactc gcctatagcg
     1681 atggcctgca ctacatcact gatcctgagc acatgcgggt cgcggtggac gacttgctga
     1741 gcgatcacta cgccgcccat cgtcgggcgc agatcggtga gcaagccgtg gcgcctcaac
     1801 cgggtgatcc ccatgccagc ggcacggtgt acctggcaac cgctgatgcg gaaggcaaca
     1861 tggtgtcgtt catccagagc aactaccacg ggttcggctc cggtgtggtg ctgcccgaca
     1921 gtggcatcgc cctgcaaaac cgtggcgaag agttcagcct ggatcccgag catgccaatt
     1981 gcctggcacc cggcaagaag accttccaca ccattattcc ggggtttctc agcaaggatg
     2041 gtgtggccat ggggcccttc ggcgtgatgg gcggctacat gcaaccgcaa gggcacgtgc
     2101 agatggtcat gaacctggtg gatttcggac tcaacccgca agcggcgctc gacgctccac
     2161 gctggcagtg gctgggcggg ctgaaggtcg gcatcgagca gaacgcttcg cgggatatgg
     2221 ccgccgcatt ggcgcgtcgc gggcatgagg tgcaagtggt gtgcgacctc accagctacg
     2281 ggcgcgggca aattatcctg cgcgatcctg aaaccggcgt gttatgcggg gggactgaac
     2341 cgcgggcgga ttcgcatatc gcggtgtatt gaagtgctgg tgggaaggcg agggcgccgt
     2401 gccttcgctt gcctgcttta gtaacttctt tgggggaaat gactgcgcaa taggctgggg
     2461 aaatgaatga aatcgagggg ggcgtcctcc ttgacgccga cgcagcttag aggctgtgcg
     2521 attgattctc aagtgctatt tgtcgttagt ttggcccaat gatgccgggc tacgcttgcc
     2581 agccaatatt cttttgatat catccgcgcc atcgaatttg cggcacctaa agacttcatt
     2641 agcctgaagc tataagccag aaaactggca aaaaaaagac ccggcaaaaa gccgggtcaa
     2701 aaaccgtgat tagcctgatg aggagatagt ccaaggatcc gacctaaggt cccttggccc
     2761 atcgactgat ctcgcgacca gttggtgcaa taataatcat tctcgtttgc aagtcaaatg
     2821 attttatctg cgtgattgga aaattctttc cagtcctctg tttaaatacc ttcgcctcac
     2881 ccgttctgat ggccctccag ggaccgatct accatggctt tagccatatc gatcatatgc
     2941 accgtcgaaa acgccagatc ccggctcgca ccctgcaagt ggttggctga ttcgtgcgcc
     3001 gtagctgcag cacaacgcag tagatccgac gcatgaacca gtgcctcttc acagctgata
     3061 tttcggttca catcaaagaa acgctcctcg acgccttcct ctgaaacagc tggtttcaag
     3121 tagtagtcca acgcgcgctg cgcagcggca gagccttgag gcgaggtgag ggacgtgtcg
     3181 atttgcatgt caggcaagtc attgacgggt tggttcatgg tgatggcaag ctccgtgata
     3241 gattcagatc cgtgaattca tcctagtacg atctgtattt gtgaccataa attaaatact
     3301 acaatttgtg ttttgatggc cggagtcgcc cacgtatcgt gccgcacatg gataaatgga
     3361 ttgaattggt caaggccaag atgagtgaac tcaaagtcac tcaagagata ctcgccgagc
     3421 gcctcgggat gtcccagggc ggcatcgggc attggctgac aaaacgccgg caacccggca
     3481 tcgacgacat gaatcgtgtc ttgcacgcgc tgggtctggg atttctggaa gtggcgctgg
     3541 tgatccggga gccactggac tcacaggacg atgaaatttc gctgacgcaa aagtacaacc
     3601 cgtacttccg ctacccggtc agtgactggc gggaaaccag cgaagtgcgt gatggcgaac
     3661 aggcccagta ccgtttcgaa ttgtccgatt accatgcaca aggcgcggca ttctggttga
     3721 cggtcgcagg tgatgcgatg accgcaccca cgggtctcag catcgccgaa ggcatgctga
     3781 ttctggtgga ccccgacgtg gaggcggagc caggcaagct ggtgattgcg caatggccca
     3841 gcagcagcga ggcgattttt cgcaagctga tcgaagaagg cgggcagcgt tacctggtcc
     3901 cgcttaatcc gacgtacccg aaagcccttt tcaccgaaga gtgccgaatc atcggcgtgg
     3961 tggttcaggc aacagccaag ttttaatcag atcggtcctc gcatggcgta ggaccgatcc
     4021 tcttttcacg cttcttccag ttcgaccagc gcactgcctt cgctgaccat ttcgccttcc
     4081 tggcaataca gcgccttgat cacccctgcg tgtggtgctc ggatactgtg ctccatcttc
     4141 atcgcttcca gcaccaccag ttgcgctccg gcttcaaccg cttgaccggc ctctaccagc
     4201 acacgaacga tgcttccgtt catcggtgcg gtcagcccgc cctgatggct gtggctggct
     4261 tcgacagcac tgatcgggtc gtaggactcg atgcggcgca gttcaccctc ccattgcagg
     4321 tacacccctg cgccacggcg gatcgcccga tgctggcggc gtacaccgtc gtgctcggtc
     4381 agcaattgct cgcccttgag ttgcgcggtt tggatgttga ggttgcccaa tgtcagcgcc
     4441 ctgtcttgcc cttcgcagct caaatgcaga gtgatttctg tcggcagtcc cgcccggaaa
     4501 ccgttgctgt tggcccatgg cgagctcagg tcatcggcgc gaaatgaatg aggctggctc
     4561 tgggcaaacg cctgggcggc ggcttgccag aattcatcgc tcagtgcggc aggcggtggc
     4621 agcagttgtt cctgataacg cggaatgaac ccggtatcca gttcggctgc ggcaaatgcc
     4681 gggtggccga tgattcggcg caggaaattg atattggtct tgagcccgcc aatcgcaaat
     4741 tcatcgagca tgctcaacaa tcgcaagcgc gcctgttcac ggtcttcgcc ccaggcgatc
     4801 agtttgccga gcatcgggtc gtagaacggc gaaatgtcgt cgccttcttc gacgccactg
     4861 tccactcgac ggcccggacc ttgtgcggat tcgcgataca actccaggcg cccggttgca
     4921 ggcagaaaat cattgcccgg gtcttcggca tacagccgca cttcaatggc atggccgatc
     4981 agcggaacct gttcctgagt catcggcagg gcttcaccac gcgccacacg aatctgccag
     5041 gccaccaggt cgaggccggt aatggcttcg gtgacggggt gctcgacttg cagacgcgtg
     5101 ttcatctcca tgaagaagaa ctcgccgcgc gcgtccagca agaattccac agtgccagca
     5161 ccgacgtaac cgatggcttg cgccgaacgc actgccgctt cacccatggc gcggcgcaat
     5221 tgcggactaa ggcctggtgc gggtgcctct tcgacgactt tttggtgtcg acgctggatg
     5281 gagcagtcac gttcgttgag atacaggcag ttgccatgct ggtcggcgaa cacctggatt
     5341 tccacgtggc gtggttggag caggtacttc tccaccagca tccgcgaatc gccgaacgac
     5401 gacagtgctt cacgctgggc cgaggccagg gcttcggcca gttggctgac gtcctcgacc
     5461 actttcatgc ctttaccgcc accaccggcg gtagccttga gcagcaccgg gtagccgatg
     5521 cgttcgcagg cagcgcggaa ggtgtccagg tcttgcgcct cgccgtgata accaggcacc
     5581 agcggcacgc cagcggtttc catcaaggcc ttggccgcgg atttgctgcc catggcgtcg
     5641 atggccgagg cgggcgggcc gaggaaaatc agaccggccg cttcgatcgc acgggcgaac
     5701 ccggcgttct ccgacaaaaa gccataaccg gggtggattg cctgagcacc gctggccttg
     5761 gcggcggcga tcagtttgtc gatttgcagg tagctctcgg cagctttgct gccacccagg
     5821 tcgacgcgaa tgtcggcttc gcggctgtgg cgagcatcac ggtcggtggc gctgtgtacg
     5881 gccacagtgg tcaggcccag agccttggcg gtacgcatca cccggcaagc gatttcgccg
     5941 cggttggcca ccagcagggt agtgaggaca ggtgcgctca tcaacgcggc tccttggtgg
     6001 tggtttcgtc ctgccagctc ggcggacgtt tttgcagaaa agcgcgcagg ccttcctggc
     6061 cctcgggact gacacggatt cgcgcgatgg cattttcggt gtagcgacgc agtgacggcg
     6121 tcagcgagcc gtcgccgact tcgcgcagca ggtccttgct ggcacgcatg gcggcggggc
     6181 tgttgagcag caggttgtcg atccactgtt cgacgttctg ttccagctca gaggaaggat
     6241 aactctccga caacaaaccg atttcccgag cccgttgtcc gccgaaacgt tcagcggtca
     6301 aggcataacg ccgtgccgcg cgttcgccaa tggcttgcac cacgaacggg ctgatcacgg
     6361 ccggcgccag gccgatgcgc acttccgaca ggcagaattg tgcttcatcg gcaccaatgg
     6421 ccatgtcgca gcaactgatc aggcccaagg caccaccgaa ggctgcacct tgcaccactg
     6481 ccagggtcgg aactttcagt ttggcgaggt tgtacatcaa ctccgccagt tcccgagcgt
     6541 cgtcgaggtt ggtgtggtaa tcgagttcgg ccgattgctg catccaggcc aggtcggcac
     6601 cggcactgaa atgtttaccg cggccgcgca ccaacaggaa acgcaggctg gcatcgctcg
     6661 ccaccttgtc catcgcgatg atcagttcac ggatcatctc ggcgttgaac gcattgttct
     6721 tttcttcgcg gcttagccac agggtcgcaa aaccacgcgg gtcggtctgc agttcgaggg
     6781 tgttgaagtc gctcatgttc gtccgtctcc acggtctctg taggagcgag cttgctcgcg
     6841 attgcggtgt gtcaaatgac catgatgggg actgacactc catcgcgagc aagctcgctc
     6901 ctgcaagaaa atcacatccg gaacacgccg aagcggctcg gttcgattgg cgcattcagc
     6961 gacgccgaca aggccaggcc caagacatcg cgggtctgtg ccgggtcgat gacaccgtcg
     7021 tcccacaagc gcgcactgga atagtagggg tggccctgtt cttcgtactg gtcgaggatc
     7081 ggttgcttga tgtcggcttc ctgctcggcg ctgaaaccct ggccactgcg ctcggcctgc
     7141 tcgcgcttga cctgcaccag cacaccagca gcttgttcgg cgcccatcac gccgatgcgc
     7201 gcgttcggcc acatccacag gaaacgtggg tcgtaagccc ggccgcacat gccgtagtta
     7261 ccggcgccga agctaccgcc gatgatcacg gtgaatttcg gcaccttggc gcacgctacg
     7321 gcggtcacca gtttcgcgcc gtgcttggca atgccgccgg cctcgtattt ctggccgacc
     7381 atgaaaccgg tgatgttttg caggaacagc aacgggatgc cgcgctgaca ggccagttca
     7441 atgaaatgcg cgcctttctg cgcggcttcg gcgaagagga tgccgttatt ggcgaggatc
     7501 gcgatcgggt aaccgtgcag gtaggaaaag ccgcatacca gcgtagttcc gaacaaggct
     7561 ttgaattcgt cgaacaccga accgtccacc agccgtgcga tgacttcgcg cacgtcaaac
     7621 ggttgcttgg catcggccgg gaccacgccg tacagctcgt cgctgttgta cagaggggcg
     7681 atgggcgtgc gttgctgcag ttcgccaagc ttgcgccagt tgaggttggc gacactgcgt
     7741 cgagcaatgg ccagggcgtg ttcatcgctc tcggcgtagt ggtcggccac cccggaaatc
     7801 ttgcagtgca catcggcccc accgagatct tcggcgctga ccacttcacc agtcgccgct
     7861 tttaccagcg gcgggccggc caggaagatg gtcgcttgct cgcgaaccat gatcgcttcg
     7921 tcggccatcg ccgggacata agcgccgcca gcggtgcaag agcccatgac cacggcaatc
     7981 tgcgggatgc ccatggcgct catgttggcc tggttgaaga agattcgacc gaagtgctca
     8041 cggtccggaa acacttcgtc ctgacgcggc aggttggcgc cgccggagtc caccagataa
     8101 atacacggca ggcgattctg ctgggcgatg gtctgggcac gcaggtgctt tttcacggtc
     8161 agcgggtagt acgaaccacc tttcaccgtg gcgtcgttgg cgacgatcat gcattcgacg
     8221 ccttcgacac ggccgatccc ggcaatcaca ccagcggccg gcacgtcttc gccgtacacc
     8281 tcgtaggccg ccaattggct gatttcgaga aacggcgagc ctggatcgag cagacgattg
     8341 atgcgctcgc gcggcagcaa tttaccgcgc gaagtgtggc gttcttgcgc cttaggaccg
     8401 ccaccttgcg ccacttgggc gagcagagtg tgcagggcgt cgacctgttt gagcatcgcc
     8461 gcactgttgg cggcgaactc cgccgaacga gggttgagct gggtatgcag gatagccatg
     8521 gacagctccg tttagcgggt ttcgttgaac agttcgcgac cgatgagcat gcgacggatc
     8581 tcactggtgc cggcgccgat ttcgtacagc ttggcgtctc gcagcagacg accagccggg
     8641 aattcgttga tgtagccatt gccaccgaga atctggatcg cgtcgagggc catttgcgtg
     8701 gcgcgttcgg cgctgtagag gatcacgcca gcggcgtcct tgcgtgtggt ctcgccgcgc
     8761 tcgcatgcct gggcaaccgc gtacaggtag gcgcggctgg cattgagttg ggtgtacatg
     8821 tcagcgactt tgccctggat cagctggaat tcgccgatgc tttggccgaa ctgtttgcgg
     8881 tcatggatgt acggcacgat caagtccatg caggcctgca tgatccccgt cgggccgccc
     8941 gaaagcacaa cgcgctcgta gtcgaggccg ctcatcagga ctttcacgcc gccgttgagc
     9001 acgccgagaa tgttttcttc cggtacttca acgtcatcga aaaacagctc gcaagtgttc
     9061 gagccgcgca tgccgagctt gtcgaatttg ttgctgcggc tgaagccttt ccagtcgcgc
     9121 tcgacaatga acgcggtgat accgtgtggg cctttttcca ggtcggtctt ggcgtagatc
     9181 acgtaggtgt tggcgtccgg gccgttggtg atccaggtct tgctgccatt gagcacgtag
     9241 cgatcgccac gcttgtcggc ccgcagcttc atcgatacca cgtcggaacc ggcattcggc
     9301 tcgctcatgg ccaaggcgcc gatatgctcg ccactgatca gcttcggcag gtatttggtt
     9361 ttttgctcgt gattgccgtt gcggttgatc tggttgacgc agaggttgga gtgcgcgccg
     9421 taggacaggg ccaccgaagc cgagccacga ctgatttctt ccatggctac aacgtgggcc
     9481 agataaccca ggcccgcgcc gccgtactct tccgggacag tgacacccag caggcccatg
     9541 tcgccgaatt tgcgccacag gtcggcgggg aagaggttat cgatgtcgat ttgagcggcg
     9601 cgcggggcga tctctttggc gacgaaggac tgaacctgat cgcgcaacat gtcgatggtt
     9661 tcaccgaggg caaagttcag ggatgggtag ctcatgggtc accttttggc tttttttgta
     9721 ggggtgggga gggcagtgat tcaactctca cctttacgtt aacgtaagcc tgtgacgaat
     9781 ggctgtcaat caccctttac gttaacgtca acttgagcga gagtaggggc agttcaagat
     9841 agaacgcgga ccaatctctg taggagcgag cgtgctcgcg atgagcctga aggcgacgca
     9901 tttttcggac tatacgcgtc atcgttgacc tccatcgcga gcaagctcgc tcctgcaggt
     9961 aaccgctggt agcccattaa taaagacaat aggggtcgtc atggatcaac ccagtgtaaa
    10021 cccgcagcgc agctacaccc gtggctcaca ggacaaagcc ttgctggcga tgaccattgg
    10081 ccaggcgttc gacaacaccg tcgctcagca tccgaacggg gaggcgctgg tggtgcgcca
    10141 tcaacagctg cgctacacct ggcgacaact ggcggacgct gcagacctgc atgccagagc
    10201 gctgttggcg ctgggcctgc agactggcga ccgtctcggt atctgggcac ccaactgtgc
    10261 acagtggtgc atcagtcaga ttgccagtgc aaaaatcggc gtgatcctgg tcaatatcaa
    10321 ccctgcttac cgcagttccg aactcgaata cgtattgaag caatccggct gccaatggct
    10381 ggtctgcgcc ggggccttca agacgtccaa ctaccacgtc atggtgcaag gcctggtacc
    10441 ggaactggcg cagcagtcca tcggaaaatt gcacagtgaa cgcctgccag aactgcgcgg
    10501 cgtcatcagt ctggatgcgc agccgcccgt cggtttcctg ccgtggtcgc agctggcgga
    10561 tctggcgggc agcgtctcgg tggagcagtt gcacgaacgc cagggcagcc tgcatttcga
    10621 tcaagcggtg aatattcagt acacctccgg caccaccggt tttcccaaag gcgcgaccct
    10681 cagtcactac aacattctca acaacggtta catggtcggt gagagccttg gcctgaccgc
    10741 cgctgatcgc ctggtgatcc cggtgccgct gtatcactgc ttcggtatgg tcatgggcaa
    10801 tctcggctgc attactcacg gcagtacgat gatttacccc aacgatgcct ttgatccgct
    10861 gttgacgttg aacaccgtcg tcgaagaaaa agccacggcg ctgtacggtg tgccgaccat
    10921 gttcatcgcc atgctcgatc agccgcagcg tgcggagttt gatctgtcga gtctgcgtac
    10981 cgggatcatg gcgggggcga cgtgtcccat cgaggtgatg cgtcgggtca tcagcgaaat
    11041 gcacatgagt gaagtgcaga ttgcctacgg catgacggaa accagtccgg tgtcgttgca
    11101 gaccggtccg tcagacgacc tggaattgcg tgttaccacc gtcggacgta ctcagccgca
    11161 actcgaaagt aaaatcatcg acgaggcggg caacctggtc ccgcggggca ctattggcga
    11221 actgtgcacc cgcggttata gcgtgatgct cggttactgg aaaaatcctg aaggcacggc
    11281 agaagctatc gatcaggcgg gatggatgca caccggtgac ctggcgagca tgaacgacga
    11341 gggctatgtg tgcattgccg ggcgtaacaa ggacatgatc attcgtggcg gtgagaacgt
    11401 ttatccgcgg gagctggaag agttcttctt tacccacccg gcggtggcag acgtgcaggt
    11461 gatcggaatt ccttgttcgc gttacggcga agagattgtc gcctggatca agttccaccc
    11521 cggccacagc gccaccgagc aggagctgca aacctggtgc aaggagcgca ttgcgcactt
    11581 caagacgccg cgttacttca aattcgtcga ggagtttccg atgacagtga ccggcaagat
    11641 ccagaaattc cgcatgcgtg aaataagcat cgaggatctc aaagcgtcac ggtaaaaaaa
    11701 taagaagacc gcagccttcg gcagctccta caggtgcaca caaaaccatg taggagctgc
    11761 cgaaggctgc gatcttttaa aaagccaaac accagacagc acaaagggga gccgaagctc
    11821 ccctttaatt tttcgttgcg cgtgctcttt ttttattatt gaggggcggt ctgtttttgt
    11881 ttttggtaac cgtgaccctt taccgctgtt tttttcgatc cccatccggg atcaagagca
    11941 aacgtatttt tttgagcgct gatctacttt ttcgctaagc gatccaacca gttcgggagc
    12001 tacctcaagg tagttttatt gttctctgcc cggttgcggg ttactccgaa aagcaccctg
    12061 aaaagcacat cttctccaaa aaaatctgtt agctgcgtct ctgccgtgtt gtttttgtta
    12121 tgtcagagtc gttacgtctt gtttttatta ggtttgccgc tttttttatt cttgttatgc
    12181 aatagagata gcaggtgtcg tgccaacttt taaaaaccct ttaaaatcaa cagtttgaaa
    12241 ttttgtaagg tttttcactc aggcaaaccc tgacaatttg tttccgtgtt actcgctttt
    12301 gcccacgttt cagatacagc ggtaacacct ggacacatcc gcgcactcac tgtgcgcttc
    12361 gggccttggc cacacgcgaa ccggtcgggc ggcccagcac gctgcaaatc tgctggccgg
    12421 ccaggatcaa cgtatccagg ttgattccgg tttcaattcc cagcccgttg agcaggtaaa
    12481 ccacgtcttc cgtggcgacg ttaccgctgg cgcccttggc atacgggcag ccgccgagac
    12541 cagcgataga gctgtcgaac accgagatgc cttccagcag gctggcgtag atgttggcca
    12601 ttgcctggcc gtaggtgtcg tggaagtgcc cggccagttt gtcccgtggc acgacggccg
    12661 agaccacatc gaacatcttg cgggtcgcgc cagcggtacc ggtaccgatg gtgtcgccca
    12721 acgaaacctc gtagcagccc atggcgtaga gctcgcgggc gacgtgggcg acctgttccg
    12781 gcgtgacgtt accttcatag gggcagccca gcacacagga cacgtaaccc ctcactgaca
    12841 caccgtgttg tttggccgca tccatgatcg gcacgaaacg ctccaggctt tcgctgatcg
    12901 agcaattgat attgcgttgt gagaacgctt cggacgcggc ggcaaacacc gcaacttcct
    12961 tgaccccgga ggcgagggca tcttcaaaac cgcgaaggtt gggggcgagt gcgccgtagg
    13021 tcacacccgg tttgcgctgg atctgcgcga agacctcggc agagcctgcc atctgtggca
    13081 cccatttggg cgagacgaaa ctgccgactt ctatatagcc gaggcccgcg gccgtcagtg
    13141 catcgaccag ttgcaccttg tcggcgacgc tgatgggttg ggcttcgttt tgcagaccgt
    13201 cgcgggggcc gacttcgaca aggcgtactt tggttggaag ggacatggga ttggacctgt
    13261 gctgattgtc tgatgctcag agaaccctgt agaagccgag cttgctcgcg atggcgctct
    13321 ttcagtcaac atcaatgttg aaagtcacgc cctcatcgcg agcaagctcg gctcctacag
    13381 tggatgggcg ggtttactga atgacttcct gactcttgat cgtctgctcc agcgcctgga
    13441 tgcaacgctc ctgcgcggta tccagttcaa gcttcatctg ttcgatgtcg agcatctgct
    13501 gctccagctg ttcgcgacgt tcggcgattt tggtcagcat ggtttgcagc tgtttttgat
    13561 tgccaccggt ggggtcgtag agctcgatca gctcacggca ctcggcgagt gagaagccga
    13621 tgcgcttgcc ccgcaggatc agcttcaggc tgaccttgtc acggggcgaa tagatccgtt
    13681 cctgaccgcg ccgttccggg ctgagcaggc cttgctcttc atagaatcga atcgcccggg
    13741 tggtgatatc gagctcgcgg gcaaggtcgg aaatgctgta ggtctggctg ctcatgggcg
    13801 cgctcgcaaa aggtcatggc gctaagctaa tgtcaggttg acgtttacgt caagggagaa
    13861 aagatcgcag ccttcggcag ctcagagcat tccaaggagc tgccgcaggc tgcgatcttt
    13921 tgatcttcat caaaccacct gcttatccag ctttttctcg tgcgccgtca cctgctggca
    13981 caactcgatc atctgctcgc gcatccagcg gttggccggg tcctggtcgg tgctttcgtg
    14041 ccagtagaga tgggtttcca cgggcggtac gtcgttgacc ggcaggctga aagcatgcag
    14101 gtcattacgg cgggcgaagc gttccggcac ggtcatgacc atgtctgtct gctgcaacac
    14161 ttgcgaggcc atcaggtaat gctgtgagcg cagggcgatc ttgcgctgga tgcccatctt
    14221 gcccagggcc aggtcgacat ggcccagacc gctgcggcgg ctggagatgt ggatgtgggt
    14281 caggcccagg taatcatcga gggtgaattt ttctttgccg gccagaggat gtcccttgcg
    14341 catggcacac acgtagcgat cttccatcaa cttgacgtga cgcacttgcg ggtcggtgtt
    14401 gagcggcgca tccaccgcga agtcgaggcg accggcggcc agctccttgg tggtctcgcg
    14461 gcgtttggac aggaagctct caatgatcac cgtcggcgcc aggcggcgca ggcgctggaa
    14521 cagcggtggc aggatcaccg cttcggtgag gtcggtcatg ctgatgcgat aggtcttgac
    14581 cgcctgcagc gggttgaaaa tgcggctttc ctgtaccgat acgcgcaata gcgagagcgc
    14641 gttacgcacc gggccgataa tgttctgggc catcggcgtc ggcaccatgc cttgggcagt
    14701 acgcacgaac aacgggtcgt tgaaggtctc gcgcagacgg gccagggcgt tcgacaccgc
    14761 cggttgggtg atgccgacaa tctgcccggc gcgggtcagg ttggcttcgg tgtagatcgc
    14821 gtcgaagacg atgaaaaggt tgaggtcgac cttgctcaga ttcatgcgct gcactcttgt
    14881 ttttaggggc gtcttgatcg gacccgaggg ccttgccaat cagccgatca tatatcggtg
    14941 atgaatgtta atacacgccg agaataggct aggtaaattt tcgtagttgt tctagcatcg
    15001 attgcatgac ctgaacaact catcgaaacc ccgttaaaaa ggtagagctg cccatggatt
    15061 tcgcttattc gcccaaggtg caacaactgc gtgagcgcgt gaccgcgttc atggacacct
    15121 acgtttatcc cgccgaagcc gtgttcgagc gccaagtcgc cgagggcgat cgctggcagc
    15181 cgacggcaat catggaagaa ctcaaactca aggccaaggc cgaaggcttg tggaatttgt
    15241 ttctccctga gtccgaactc ggcgccggcc tgaccaacct cgaatacgca cccctggcgg
    15301 aaatcatggg acgctcgttg ctgggccctg agccgttcaa ttgctccgcg ccggacaccg
    15361 gcaacatgga agtgctggtg cgctacgcta atgaagaaca gaaacaacgc tggctagaac
    15421 cgctgttgcg cggcgagatt cgctccgcgt tcgccatgac tgagccggac gttgcgtcct
    15481 ccgatgccac caacatggcc gcccgagccg tgcgcgatgg tgacgagtgg gtgatcaacg
    15541 gcaagaaatg gtggacctcc ggcgcctgtg atccacgctg caagatcctg atcttcatgg
    15601 gcctgagcaa ccccgacgcg ccgcgccatg cccagcactc gatgattctg gtgccggtcg
    15661 atacccccgg cgtgaagatc gtgcgtccgc tgccggtgtt cggttacgac gacgcgccgc
    15721 acggccatgc cgaagtgcta ttcgaaaacg tgcgggtgcc gtacgaaaac gtcctgctgg
    15781 gcgaaggacg cggcttcgaa atcgcccaag gccgcctcgg ccctggccgg attcaccact
    15841 gcatgcgttc gatcggcatg gctgaacgcg cactggaatt gatgtgcaag cgctcggtga
    15901 accgtacggc gttcggcaag ccgctggcac gcctgggtgg caacatcgac aagatcgccg
    15961 actcgcggat ggagatcgac atggcgcgcc tgctgacctt gaaagcggcg tacatgatgg
    16021 acaccgttgg caacaaagtg gccaaaagtg aaatcgcgca gatcaaggtc gtggcgccga
    16081 acgtggcctt gcgggtgatc gaccgggcga tccagattca tggcggggca ggggtttcaa
    16141 atgatttccc gctggcctac atgtatgcga tgcagcgaac tctgcgcctg gccgatggcc
    16201 cggacgaagt gcaccgcgcg gcgatcggca agttcgagat cggcaagtac gtgccgaagg
    16261 aaatgatgcg tagcagtcat taagaccgag tcatcgttct tcgcgggcaa gcctcgctcc
    16321 tacaggttta gtgtgacctg taggagcgag gcttgcccgc gaaggcgtcc gcctattcaa
    16381 cacagcaaca tgagattcag taaacccaaa cctcaacccg ccgattcttg atccgccctt
    16441 catccgcgct attggccgcc actggcatct cggcgccaaa gccacgaatc tcgcggaaca
    16501 ccacgccgct tttcaccagt tctcgtcgca ccgccatggc ccgcaacttc gacagtagat
    16561 cggcgcgtgc cgggtcgctc ttggcatcgc caaatcccac cagtgttacc tgccgatcgg
    16621 ttttgtcgtg ttgctttata tagtcgagca cccgtgaaag gtcctgccgt gccttgttgt
    16681 ccaggctggc gctgccttct tcgaagcgaa agttcacggt cagtcgctgg gcgtgacggc
    16741 tgagcgcctg ataaccctcg ggcatcaacg cattcggcgt gacggccatg gcctgcaccg
    16801 tctgggcgat aaaaccgttg gcggcgacaa tcgcctggcc ctggctgctc tgggcgaacg
    16861 ctaccagcgc ttcggcccag ggattgttcc cggcaggcgg caggtaaaag aacaatcggc
    16921 gcgacagcgg gtagtcttcc gtggcgatca ggctgttgag cggcaacatg gcctgggatt
    16981 gaccgtcgac aatcgccacg gccttggcct gacgcacgta gggcaagccg ataaaaccga
    17041 tagcttgcgg gtccaggctg acagcgtcgg acaactgctc gctggattcg aaccgtttcg
    17101 ccgcgctgct caggtttttc ccacggctgc tgaggactaa ttccttgaag gtgtcgtacg
    17161 tgccggactg atcatcccgt gcatacagat gaatcgttcc accgctgccg ccgagttctt
    17221 cccaggtttt ggcttcgcca ctgaaaatgc gcgccagttg cacggtgttg agttggttca
    17281 gcgggttttg cgggtgaagg atgatcgcca ggccgtcgat cgcgataacc tgttcggcgc
    17341 cggcgctttt cagatcgccg agcatctgca ggtcaaccac ctcgctgtcc ttgatcggac
    17401 gcgatgaagc ggcgaggtcg gcgttggcgg ttttcagtgc ggtgaaaccg gtgctggaac
    17461 cgtgggccgc gagttccacc tcgacccggc gtccttgtag ggtttcacca acgatccgca
    17521 gctcgttggc cttgtccggg gcttcgctgt gcacctttag cagaccctgt tcacgcaaca
    17581 acccttcgac cagcgccgga cccagtgccg cgccgatggt gttggaaccc tggatgcgta
    17641 gcaccgggcc atggtcgggc accggcaagc cgctggccgc ggccatttgt ggcagccaat
    17701 tgcacagcat caacaggaac aacacgcgca gcgtcatgcc ggcaccttaa atagccaaag
    17761 gaggtgccag gagattaagt cagtaaggtt tccaaaaaat gacagatcaa aagatcgtcc
    17821 gaacgcggcc cgatcctgcg gcagtgggat ttgcattcac ctgtaggagc tgccgaaggc
    17881 tgcgatcttt tgatcttttg atcttttgat cttttgatct tttgatcttt tgcttttagc
    17941 tcaactcaag ccagatcggc gcatggtccg aaggcttttc cataccgcgc agttcgtaat
    18001 ccacgccagc atccttgacc cgtggcaaca gcccgtggga cgccatgatc acgtcgatcc
    18061 gcagcccacg cttgggctcg tcctcaaagc cgcggctgcg atagtcgaac caactgaagc
    18121 ggtcggccac ctccgggttc aggtgacgga agctgtccac caggccccag tttttcaggc
    18181 gggccatcca ctcgcgttct tcgggcagga agctgcactt accggttttc agccagcgct
    18241 tcatgttatc ggggccgatg ccgatgtcgc agtcttccgg ggagatgttc acatcaccca
    18301 tcactacaag cggctgatcg tttttgaact gggtttccag cagttgctgc agatcgttgt
    18361 aaaaacgttg cttggctggg aatttggtcg ggtggtcgcg gctttcacct tgtgggaaat
    18421 agccgttcat gatcgtcacc ggcacgccgt tggcgtcagc gaaagtgccc caaatgaagc
    18481 gccgctgagc atcttcttca tcggtggcaa aacctttgtg caacgccagc ggttcttgac
    18541 gcgacagcag ggcgacaccg tagtgaccct tttgcccgtg gaaatacacg tggtagccca
    18601 gggctttgac ttcatcgagc gggaactggt cgtcgtggac cttggtttcc tgcaaaccga
    18661 tcacatcggg ctggtgcttt tcgatcagcg ccgccagctg atggggacga gcgcgcagcc
    18721 cgttgatgtt gaaggagacg atcttcatgg tcggcagtcc tggcaaaagg gcgatgctag
    18781 ctgacatgtg ggaatcgggc cagtgttggg gtgaggggat ttactcagtt ctgtgagatc
    18841 tctgctggtg gtaccggcct cttcgcgggc aagcctcgct cctgcagtga atcggtgtca
    18901 tccataaaac ctgtaggagc gaggcttgcc cgcgaagtgg ccggcagtac taacaaattc
    18961 agctcggctc gacgcattag ttggctcgcc atcccatgtc tggtctatac ctgtggggga
    19021 actgtgtcgt cacccaacgg ctcgtaacaa caagagtgca gccctccgag ctgtgccggg
    19081 gagatcaacc gtcatgcccg aaacctcgat cgccatcgcc gatattcaca tgctcgacag
    19141 cggctattcc cgcgaagcgc gatccctgtt gtatcaggct taccggcacg agccgacgtt
    19201 cggctatctg ttcgaagcag aacgtcccgg ttatgagcag cgggtgcgcg ccaccgtacg
    19261 cgaactggtc aaacagcact ttctacaaga tttgccggcc atcggcctgc tggtcaacga
    19321 ccgcttgatc ggcatcgctt tgatcgcgcc gccgcaacgg cgtctgggca tcacggagag
    19381 ttgggcctgg cgtctgcgca tggtgctcag caccggattt cgctgcaccc gccgttacct
    19441 cgaatatcac gatgcggtga tggcttgtgt gccgtccgat tcggtgcact tgctgccgtt
    19501 gctggggatt cacccgcaat ttcaaggcaa gcacttcggt gaacaactgc tgcaagcggt
    19561 ccataactgg tgcgcagtcg atgagcactc tcagggcgtt gtccttgata ccggcaatcc
    19621 gcgctatctg gagttctata aacgtcaggg ctatgaggaa atcggtgagg ttgccgtagg
    19681 cccgatccgt gaacatgtgt tttttcacgc caaccctcag gtggtacaaa cagcgacggc
    19741 ataaacatcg aactttcggg accggccagg ctctatcacg ctcccttgtt caagttccgc
    19801 tcgtgatagc atccgcgcct atgaagtttc caggaagaat taccagtggc gtgctgatgc
    19861 tgatttccag ctgcgcggcg ctggcgcaaa gtgaattgga tgtgcggatc aaaccgtcca
    19921 acgacgaact gaaagccaat atagagggct atatcggcag ccttggcgat cgtgacgaag
    19981 aagccttgct gcgcttcagt cgtggcgccg aggaacaggc gcgcaaggcc gcccaggcct
    20041 tgggttacta ccagccgcag atcgacagcg acgtgaaggg cggcaaaaaa ccgcgtttga
    20101 tactgaccat cgaccctggc gagccggtgc atttgcgcaa cgtcaccatc cgtatcgacg
    20161 gtccggccgc ttccctcaaa tcctttcgct tacccaatga ccacgcgctg aaaaccggcg
    20221 cggtactcaa ccatggtcat tacgaagacg ccaagcggct gatccagaac caggcctcgc
    20281 gttacggttt cttcaatggg cgctttacca gttcgaaact ctcggtggac ccgcgagccg
    20341 gcgtcgccga tatcgaactg atctacgaca gcgggccgcg ttattccctg ggcaaggtca
    20401 gttttgaagg cgacacgccg ttcgacgagg acctgctgca acgcatggtg ccgttcaagg
    20461 cgggcgcgcc gtatgactcc gagctgatcg ccgaactcaa ccaggcgatg caatcgagcg
    20521 gctatttcga gagcgttcga gtggacgcga caccgaccgc gtccaaggac aatgtgatcc
    20581 cggtggacgt taagctcgaa acccgcaagc cgcgcaccat gggcctcggg ctgggctatt
    20641 ccactgacgt cggcccgcgg atcaaggcca actggacccg gcactgggtc aatccgcagg
    20701 ggcacagcta tggctgggaa accgaagtct cggcgccacg gcaaaatgtc ggggtgtttt
    20761 acgacattcc cctggacccg ccgctgaccg acaaactgcg tttcgccggc ggctatcaaa
    20821 atgaagaaat tgccgacaag gacagcctga gcaagctgct gaccctcggc cccgagtggc
    20881 acagcaagtt gcccagcggc tggcagcgcg tggtgtcact caagtggcag cgcgaggaat
    20941 accgcctcgg tgacgactca gggctcagca ccttgctgat gcccggcgtg agttattcgt
    21001 acctgaaaag tgacaaccgt atcgatccgc acaacggcta tcgtctgcaa ttcgaaagca
    21061 aagtggccaa ggaaggcctg ggttctgata acaatctggt ttacggcacg gcattggtca
    21121 aaggcctgac cacggtcttc gacaaacacc gtttcctggg tcgggtgcag gtcggtggca
    21181 gtgccaccaa cggctacaag tcggtgccgc catcgctgcg gtttttcgcc ggtggcgatc
    21241 agagcgtgcg cggctacgac taccaaagcc tgtccccgga aaacaacgag ggtgaccgta
    21301 tcggtggtcg ctacatggtc accgccagcg cggagtacca gtactccatc gccgaaaagt
    21361 ggcgggttgc aacctttgtc gatcaaggca atgcctttaa tacactcgaa ctgcctaacc
    21421 tcaagaccgg ggttggtatc ggcatacgct gggtttcgcc ggtggggccg atccgcctcg
    21481 acctggccca tgcgctggac gacgatggcg gtattcgatt gcacttttcc atggggcctg
    21541 agctttgaag cgtggtttga aaataacgct gctgacaatt ttggccctgc tggtgctgat
    21601 tatcgtggcg ctgggttcgg tgctgggtac ggcaacgggc agccgctggg cacttggctt
    21661 tgttccgggt ttgacgctgg acaattttca ggggcgtttg ggcggccaat ggagcgccga
    21721 tcgcgttttg tggcagcagg acaccagccg ggttgagctg aacaaggtca tttttgcctg
    21781 gtcaccgttg tgtttgacgc gcagggcctt gtgcatcgag caattgaagg ccgatcaagt
    21841 cagcctgcaa ttcccgccgg gtacggacga aaacagcagc ggtgagatca agctcccaga
    21901 cctcaacttg ccgttggcgc tcgaacttgg tgatgtgcag gttggcagtc tgctgttcaa
    21961 cggcagtgag caactcaagg ggctgcaact ggcggcgcac tggacggcca acggcttgca
    22021 gatcgattcg gtgaaactgc agcgcgacga gctgagcctg aacctgtctg gcctgctgca
    22081 accctctggt aattggccgc tcaaggccga aggcaaactg acgctgccag cacccggccc
    22141 cgaaccgtgg gcgctggcgc taaaaatcga cggcgatctg ctgaaaaccc tgaacctgaa
    22201 cgctgccagc agcggttacc tgaacgggca actgaccggc gaattgcaac cgctggtgtc
    22261 gaacctgccc gccaaggtac gcatcaccgc cgatggcttc aaacccagtg ccgagctgcc
    22321 ggacaccttg caactcaatc aacttgagct gacgggtgaa ggcgacctga aaaacggtta
    22381 cgcgctgctc ggcaacgcct cgttgcccgc cgaactgggc ccggttgcac tgatgctgca
    22441 aggcagggtc gacgccaatg gcgcgcaaat cgccgcgctg gaactgacgg ccaacgacaa
    22501 gcaaaacctc aagctcagtg ggcaaatcga ctggagcaaa ggcctgagtg ccgaagcgaa
    22561 aatcgactgg ctggacttcc cgtggcaccg cctctatccg ctgatcgacg aacctgacgt
    22621 ggccttgcgc agtttcatcg gtgaagtctc ctacaccgac ggcaaatacc tcggcaattt
    22681 taaagcggcg ctggacggcc cggccggggc gttcagcctg accagcccgt ttgccggtga
    22741 cctgacgaaa atctacctgc aacaaattca actcaccgcc gggcagggca aggccgaagg
    22801 ccacttgaac ctgcaattcg ccgacggcat cgcctgggat accgcgctgg atctgtcggc
    22861 gatcaacccg gcgtattggg ttgccgaact accgggcact ctcgccggac cgctgcgcag
    22921 tcaaggcgaa atgaaaaacg aaaaactcag cctgagcgcc gatctcgatc tgaaaggcaa
    22981 actgcgtggc cagcctgccg tgattcaagc caaggccgat ggtggcggcg agcaatggaa
    23041 cctcaacgcg ctgcaaattc gcttgggtga caacagcatc aacggcaagg gcagcctgca
    23101 ccagaagctc gccgggcaga tcgatatcaa gctaccgcgc ctggcccagc tctggccgca
    23161 actgcgcgga caaatcaacg ggcgggtcga tgtcgctgga acactcaagg caccccaagg
    23221 caagttcggg ctgcaaggat cgcaac
//
