GCF_019037625.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAHHYI010000012.1 (Priestia megaterium (Bacillus megaterium))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii	80,988	94,992

NZ_JAHHYI010000015.1 (Priestia megaterium (Bacillus megaterium))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	lanthipeptide-class-i	1,534	27,984

NZ_JAHHYI010000001.1 (Priestia megaterium (Bacillus megaterium))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	terpene-precursor	420,946	441,842
Region 11.2	NI-siderophore	812,419	846,994	Medium	schizokinen	other:other
Region 11.3	terpene	1,003,768	1,024,586

NZ_JAHHYI010000003.1 (Priestia megaterium (Bacillus megaterium))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	T3PKS	138,902	179,987
Region 33.2	phosphonate	811,464	828,889
Region 33.3	terpene	952,664	969,567	Low	carotenoid	terpene

NZ_JAHHYI010000004.1 (Priestia megaterium (Bacillus megaterium))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 44.1	terpene	116,837	138,714

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii	80,988	94,992
Region 6.1	lanthipeptide-class-i	1,534	27,984
Region 11.1	terpene-precursor	420,946	441,842
Region 11.2	NI-siderophore	812,419	846,994	Medium	schizokinen	other:other
Region 11.3	terpene	1,003,768	1,024,586
Region 33.1	T3PKS	138,902	179,987
Region 33.2	phosphonate	811,464	828,889
Region 33.3	terpene	952,664	969,567	Low	carotenoid	terpene
Region 44.1	terpene	116,837	138,714

No secondary metabolite regions were found in these records:: NZ_JAHHYI010000010.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000011.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000013.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000014.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000016.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000017.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000018.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000019.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000020.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000021.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000022.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000023.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000024.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000025.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000026.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000027.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000028.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000029.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000002.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000030.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000031.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000032.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000033.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000034.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000035.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000036.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000037.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000038.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000039.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000040.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000041.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000042.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000043.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000044.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000045.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000046.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000047.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000048.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000049.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000050.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000051.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000052.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000053.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000054.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000055.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000056.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000057.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000058.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000059.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000005.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000060.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000061.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000006.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000007.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000008.1 (Priestia megaterium (Bacillus megaterium)); NZ_JAHHYI010000009.1 (Priestia megaterium (Bacillus megaterium))

Compact view

NZ_JAHHYI010000012.1 - Region 1 - lanthipeptide-class-ii

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Location: 80,988 - 94,992 nt. (total: 14,005 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

KM925_RS25400: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001579.4	0.43	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000503.5	0.40	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000504.5	0.38	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000502.5	0.37	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000500.5	0.37	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.37	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001579.4	0.43	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000503.5	0.40	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000504.5	0.38	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000502.5	0.37	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000500.5	0.37	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.37	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.36	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KM925_RS25400

KM925_RS25405

Leader:

MSRNQVMEELKMNHPAGAPMVEVSEDELARVYGG

Core:

GDVQPETTPACVGAGITVGIAISKLLC

Core with dehydrations:

GDVQPEDhbDhbPACysVGAGIDhbVGIAIDhaKLLCys

antiSMASH-DB 4.0 matches for KM925_RS25405

100.0%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25405_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

GDVQPETTPACVGAGITVGIAISKLLC

1

GDVQPETTPACVGAGITVGIAISKLLC

27

96.3%

NZ_FTML01000041.1:

Lanthipeptides: BW937_RS20030_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

GDVQPE+TPACVGAGITVGIAISKLLC

1

GDVQPESTPACVGAGITVGIAISKLLC

27

74.1%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

GDVQPET+PACV GI +GI ISKL C

1

GDVQPETSPACVTIGIGIGIGISKLFC

27

with 129 more sequence matches

Only the first 10 are displayed here.

67.9%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08040_lanthipeptide

1

GDVQPETTPAC-VGAGITVGIAISKLLC

27

GDVQPETT C +G GI++GIA+SKL C

1

GDVQPETTTVCAIGGGISLGIALSKLFC

28

64.3%

NZ_JAOVZP010000016.1and 1 other:

NZ_JAOVZP010000016.1 Lanthipeptides: OF830_RS26675_lanthipeptide

Lanthipeptides: OF830_RS26680_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

GDV PETTP C+ G+ GIAISKL+C

1

GDVSPETTPLCITIGVGGGIAISKLIC

27

63.0%

NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

1

GDVQPETTPACVGA--GITVGIAISK

24

DVQPETTP CVG GIT I I K

1

SDVQPETTPLCVGVIIGITASIKICK

26

63.0%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

DVQPETTPACV A +T GI S C

1

SDVQPETTPACVTA-LTTGIIFSIKWC

26

60.7%

NZ_FNYB01000007.1and 2 others:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS27180_lanthipeptideNZ_KB976303.1 Lanthipeptides: IGY_RS27695_lanthipeptide

Lanthipeptides: BMZ34_RS15960_lanthipeptide

1

GDVQPETTPAC-VGAGITVGIAISKLLC

27

GDVQPETTP C +G G+ +G +ISK+ C

1

GDVQPETTPVCAIGGGLALGFSISKIYC

28

59.3%

NZ_CP067069.1and 33 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide

Lanthipeptides: JCR32_RS24625_lanthipeptide

1

GDVQPETTPACVGA--GITVGIAISK

24

DVQPETTP CVG G+T I I K

1

SDVQPETTPLCVGVIIGLTTSIKICK

26

59.3%

NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISK

24

GDVQPETTP CVG + V I++SK

1

GDVQPETTPFCVGVIVGVTISLSK

24

59.3%

NZ_LDKE01000067.1:

Lanthipeptides: ABB04_RS19960_lanthipeptide

1

GDVQPETTPACVGA--GITVGIAISK

24

DV+PETTP CVG GIT I I K

1

SDVKPETTPLCVGVIIGITASIKICK

26

59.3%

NZ_NHVL01000036.1:

Lanthipeptides: CEU70_RS27670_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

GDV PETTPAC+ AG G +SK +C

1

GDVSPETTPACIIAGGIGGYYLSKAIC

27

59.3%

NZ_NHVL01000036.1:

Lanthipeptides: CEU70_RS27675_lanthipeptide

1

GDVQPETTPACVGAGITVGIAISKLLC

27

GDV PETTP C+ G G ISK+LC

1

GDVSPETTPVCITVGAATGYVISKVLC

27

MIBiG 4.0 matches for KM925_RS25405

10.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

12

VGAGITVGIA

21

+ AG+ VG++

15

IQAGVAVGVS

24

KM925_RS25410

Leader:

MSRNQVMEELKMNHPAGAPMVEVSEDELTRVYGG

Core:

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

Core with dehydrations:

GDVQPEDhbDhbPLCysLPDhbIPIAVDhbIGVIYDhaKKHCys

antiSMASH-DB 4.0 matches for KM925_RS25410

100.0%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25410_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

63.3%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

GDVQPETTPLC TI I IG + S K C

1

GDVQPETTPLCGFTIGIG--IGALVSVKWC

28

60.0%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

GDVQPETTP+C TI I IG + S K C

1

GDVQPETTPICGFTIGIG--IGALASVKWC

28

with 124 more sequence matches

Only the first 10 are displayed here.

59.4%

NZ_JAEKEJ010000007.1:

Lanthipeptides: JFU02_RS02780_lanthipeptide

1

GDVQPETTPLCLPTIPIA--VTIGVIYSKKHC

30

GDVQPETTPLC+ TI A +TIG+ S++ C

1

GDVQPETTPLCVSTIWYANGITIGLALSRQSC

32

56.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17170_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14620_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17335_lanthipeptide

Lanthipeptides: JNUCC31_RS17170_lanthipeptide

2

DVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

DVQPETTPLC + V IGVI S C

2

DVQPETTPLC--GFLVGVGIGVILSVTSC

28

56.7%

NZ_FTML01000041.1:

Lanthipeptides: BW937_RS20035_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

GDVQPET+P CL T V IGV S C

1

GDVQPETSPACLYT--GGVVIGVTLSIWKC

28

56.7%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08030_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

GDVQPETT C T I VTIG+ S C

1

GDVQPETTTPCAYT--IGVTIGITLSMWKC

28

56.7%

NZ_JAOVZP010000016.1and 1 other:

NZ_JAOVZP010000016.1 Lanthipeptides: OF830_RS26675_lanthipeptide

Lanthipeptides: OF830_RS26680_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

GDV PETTPLC I I V G+ SK C

1

GDVSPETTPLC---ITIGVGGGIAISKLIC

27

56.7%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIG--VIYSKKHC

30

DVQPETTP C +A TIG VI+S ++C

1

SDVQPETTPAC----AVAFTIGATVIFSVRNC

28

56.7%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08840_lanthipeptide

2

DVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

DVQPETTPLC + V IGVI S C

2

DVQPETTPLC--GFFVGVGIGVILSVAKC

28

54.8%

NZ_SDJV01000024.1:

Lanthipeptides: ES032_RS12700_lanthipeptide

1

GDVQPETTPLCLPTIPIAVTIGVIYS-KKHC

30

GDVQ ETTP C T I V+ GV+ + K HC

1

GDVQVETTPACAFTASILVSYGVVKTIKGHC

31

53.3%

NZ_CP016020.1and 34 others:

NZ_CP067069.1 Lanthipeptides: JCR32_RS24625_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25380_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25375_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25370_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25365_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25360_lanthipeptideNZ_CP085413.1 Lanthipeptides: LIS80_RS25355_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19955_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19940_lanthipeptideNZ_LDKE01000067.1 Lanthipeptides: ABB04_RS19935_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23995_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23990_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00005_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08185_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08180_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08175_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20670_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20665_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20660_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20655_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20650_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20645_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19555_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19550_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19545_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19540_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19535_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19530_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14445_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14440_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15680_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15675_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15670_lanthipeptide

Lanthipeptides: A9C19_RS17970_lanthipeptide

2

DVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

DVQPETTPLC + V IG+ S K C

2

DVQPETTPLC-----VGVIIGLTTSIKIC

25

53.3%

NZ_CP067069.1and 13 others:

NZ_CP085413.1 Lanthipeptides: LIS80_RS25350_lanthipeptideNZ_JH792105.1 Lanthipeptides: II5_RS26960_lanthipeptideNZ_JH792240.1 Lanthipeptides: IIK_RS26240_lanthipeptideNZ_MOOT01000061.1 Lanthipeptides: BK765_RS23985_lanthipeptideNZ_NTUF01000024.1 Lanthipeptides: CN379_RS26680_lanthipeptideNZ_NVCZ01000001.1 Lanthipeptides: COK75_RS01180_lanthipeptideNZ_NVDK01000008.1 Lanthipeptides: COK95_RS05665_lanthipeptideNZ_NVEA01000001.1 Lanthipeptides: COL15_RS00010_lanthipeptideNZ_PIYQ01000022.1 Lanthipeptides: CW365_RS08190_lanthipeptideNZ_WBOZ01000055.1 Lanthipeptides: F8156_RS20675_lanthipeptideNZ_WBPC01000027.1 Lanthipeptides: F8159_RS19560_lanthipeptideNZ_WBPE01000025.1 Lanthipeptides: F8161_RS14435_lanthipeptideNZ_WBPK01000016.1 Lanthipeptides: F8167_RS15685_lanthipeptide

Lanthipeptides: JCR32_RS24620_lanthipeptide

2

DVQPETTPLCLPTIPIAVTIGVIYSKKHC

30

DVQPETTPLC + V IG+ S K C

2

DVQPETTPLC-----VGVIIGITASIKIC

25

MIBiG 4.0 matches for KM925_RS25410

13.3%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

9

PLCLPTIPIAVTIGV

23

PL + T+G+

3

PLAGEEMGGITTLGI

17

KM925_RS25415

Leader:

MNHPAGAPMVEVSEDELTRVYGG

Core:

GDVQPETTPGVTALTIITLYVPSKLNC

Core with dehydrations:

GDVQPEDhbDhbPGVDhbALDhbIIDhbLYVPDhaKLNCys

antiSMASH-DB 4.0 matches for KM925_RS25415

100.0%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25415_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDVQPETTPGVTALTIITLYVPSKLNC

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

53.3%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25410_lanthipeptide

1

GDVQPETTPGV-----TALTIITLYVPSKLNC

27

GDVQPETTP A+TI +Y SK +C

1

GDVQPETTPLCLPTIPIAVTIGVIY--SKKHC

30

51.9%

NZ_JAHHYI010000012.1:

Lanthipeptides: KM925_RS25405_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDVQPETTP I SKL C

1

GDVQPETTPACVGAGITVGIAISKLLC

27

with 83 more sequence matches

Only the first 10 are displayed here.

51.9%

NZ_NHVL01000036.1:

Lanthipeptides: CEU70_RS27675_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDV PETTP + T YV SK+ C

1

GDVSPETTPVCITVGAATGYVISKVLC

27

50.0%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08040_lanthipeptide

1

GDVQPETTPGVTALTIITLYVP-SKLNC

27

GDVQPETT I+L + SKL C

1

GDVQPETTTVCAIGGGISLGIALSKLFC

28

48.3%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

1

GDVQPETTPG-VTALTIITLYVPSKLNC

27

DVQPETTP A TI + S NC

1

SDVQPETTPACAVAFTIGATVIFSVRNC

28

48.1%

NZ_FTML01000041.1:

Lanthipeptides: BW937_RS20030_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDVQPE+TP I SKL C

1

GDVQPESTPACVGAGITVGIAISKLLC

27

48.1%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDVQPET+P + I SKL C

1

GDVQPETSPACVTIGIGIGIGISKLFC

27

48.1%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

1

GDVQPETTPG-VTALT

15

DVQPETTP VTALT

1

SDVQPETTPACVTALT

16

48.1%

NZ_NHVL01000036.1:

Lanthipeptides: CEU70_RS27670_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDV PETTP I Y SK C

1

GDVSPETTPACIIAGGIGGYYLSKAIC

27

46.7%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20135_lanthipeptide

1

GDVQPETTPGVTALTI-ITLYVPSKLNC

27

GDV PETTP I IT+ V S C

1

GDVNPETTPACIYGGIAITIGVVSVAKC

28

42.9%

NZ_JAOVZP010000016.1and 1 other:

NZ_JAOVZP010000016.1 Lanthipeptides: OF830_RS26675_lanthipeptide

Lanthipeptides: OF830_RS26680_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDV PETTP + + SKL C

1

GDVSPETTPLCITIGVGGGIAISKLIC

27

41.4%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20130_lanthipeptide

1

GDVQPETTPGVTALTIITLYVPSKLNC

27

GDV PETTP I T+ + S C

1

GDVNPETTPACFYGVIGTVGLFSVAKC

27

allorf_90885_90995

Leader:

MNNVTYFREFLKQHSGA

Core:

VFFKIVAYTSSYFFTKCYK

Core with dehydrations:

VFFKIVAYDhbDhaDhaYFFDhbKCysYK

antiSMASH-DB 4.0 matches for allorf_90885_90995

100.0%

NZ_JAHHYI010000012.1:

Lanthipeptides: allorf_90885_90995_lanthipeptide

1

VFFKIVAYTSSYFFTKCYK

19

VFFKIVAYTSSYFFTKCYK

1

VFFKIVAYTSSYFFTKCYK

19

31.6%

NZ_CP062165.1:

Lanthipeptides: allorf_3871444_3871542_lanthipeptide

10

SSYFFTKCYK

19

S++ FTKCY+

8

SAFGFTKCYQ

17

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Lanthipeptides

TFBS Finder

Core peptide predictions

KM925_RS25405 - Class II

Cleavage pHMM score: 2.10

RODEO score: 0

Monoisotopic mass: 2540.4 Da

Molecular weight: 2542.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2560.0 Da N = 1; 2578.0 Da N = 2

KM925_RS25410 - Class II

Cleavage pHMM score: 0.60

RODEO score: 0

Monoisotopic mass: 3102.7 Da

Molecular weight: 3104.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3122.7 Da N = 1; 3140.7 Da N = 2; 3158.7 Da N = 3

KM925_RS25415 - Class II

Cleavage pHMM score: 0.60

RODEO score: 0

Monoisotopic mass: 2721.5 Da

Molecular weight: 2723.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2741.1 Da N = 1; 2759.2 Da N = 2; 2777.2 Da N = 3; 2795.2 Da N = 4; 2813.2 Da N = 5

allorf_90885_90995 - Class II

Cleavage pHMM score: -4.40

RODEO score: 0

Monoisotopic mass: 2269.2 Da

Molecular weight: 2270.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2288.7 Da N = 1; 2306.7 Da N = 2; 2324.7 Da N = 3

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_JAHHYI010000015.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 1,534 - 27,984 nt. (total: 26,451 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

KM925_RS26185: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

KM925_RS26230: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

KM925_RS26240: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002635.2	0.62	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.61	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.60	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000560.5	0.55	ribosomal	subtilomycin	Bacillus subtilis
BGC0000506.4	0.55	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.55	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000508.3	0.54	ribosomal	epidermin	Staphylococcus epidermidis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002635.2	0.62	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.61	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.60	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001289.5	0.60	ribosomal	penisin	Paenibacillus ehimensis
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0000560.5	0.55	ribosomal	subtilomycin	Bacillus subtilis
BGC0000506.4	0.55	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.55	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000508.3	0.54	ribosomal	epidermin	Staphylococcus epidermidis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KM925_RS26240

KM925_RS26245

Leader:

MNNVKNLFDLDVQVTTASSDVDPQ

Core:

ITSVSLCTPGCGDTGSWNSFCC

Core with dehydrations:

IDhbDhaVDhaLCysDhbPGCysGDDhbGDhaWNDhaFCysCys

antiSMASH-DB 4.0 matches for KM925_RS26245

100.0%

NC_014023.1and 36 others:

NC_014023.1 Lanthipeptides: BMQ_RS27575_lanthipeptideNZ_CP018875.1 Lanthipeptides: BUW91_RS26425_lanthipeptideNZ_CP018875.1 Lanthipeptides: BUW91_RS26420_lanthipeptideNZ_CP028091.1 Lanthipeptides: C1N54_RS28075_lanthipeptideNZ_CP028091.1 Lanthipeptides: C1N54_RS28070_lanthipeptideNZ_CP028091.1 Lanthipeptides: C1N54_RS28065_lanthipeptideNZ_CP031776.1 Lanthipeptides: D0441_RS30140_lanthipeptideNZ_CP041065.1 Lanthipeptides: FJM50_RS01185_lanthipeptideNZ_CP041065.1 Lanthipeptides: FJM50_RS01180_lanthipeptideNZ_CP041065.1 Lanthipeptides: FJM50_RS01175_lanthipeptideNZ_CP048884.1 Lanthipeptides: BMG_RS27510_lanthipeptideNZ_CP058263.1 Lanthipeptides: HW576_RS26980_lanthipeptideNZ_CP058263.1 Lanthipeptides: HW576_RS26975_lanthipeptideNZ_CP058263.1 Lanthipeptides: HW576_RS26970_lanthipeptideNZ_CP085427.1 Lanthipeptides: LIT30_RS26985_lanthipeptideNZ_CP085427.1 Lanthipeptides: LIT30_RS26980_lanthipeptideNZ_CP085427.1 Lanthipeptides: LIT30_RS26975_lanthipeptideNZ_CP085432.1 Lanthipeptides: LIT34_RS27820_lanthipeptideNZ_CP085432.1 Lanthipeptides: LIT34_RS27815_lanthipeptideNZ_CP085432.1 Lanthipeptides: LIT34_RS27810_lanthipeptideNZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25635_lanthipeptideNZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25630_lanthipeptideNZ_JACJHT010000009.1 Lanthipeptides: HNP21_RS25625_lanthipeptideNZ_JAHHYI010000015.1 Lanthipeptides: KM925_RS26245_lanthipeptideNZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28075_lanthipeptideNZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28070_lanthipeptideNZ_JANIOE010000010.1 Lanthipeptides: NQ109_RS28065_lanthipeptideNZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19640_lanthipeptideNZ_NKAQ01000005.1 Lanthipeptides: CE057_RS19635_lanthipeptideNZ_NTZG01000054.1 Lanthipeptides: CN510_RS18265_lanthipeptideNZ_NUIN01000020.1 Lanthipeptides: CN973_RS26930_lanthipeptideNZ_NUOI01000090.1 Lanthipeptides: COE08_RS30285_lanthipeptideNZ_NUOI01000090.1 Lanthipeptides: COE08_RS30280_lanthipeptideNZ_NUOQ01000009.1 Lanthipeptides: COE31_RS05925_lanthipeptideNZ_NUXL01000007.1 Lanthipeptides: COJ36_RS20885_lanthipeptideNZ_NUZS01000089.1 Lanthipeptides: COJ90_RS28785_lanthipeptide

Lanthipeptides: BMQ_RS27580_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITSVSLCTPGCGDTGSWNSFCC

1

ITSVSLCTPGCGDTGSWNSFCC

22

90.9%

NZ_FPAA01000016.1and 3 others:

NZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15995_lanthipeptideNZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15990_lanthipeptideNZ_FPAA01000016.1 Lanthipeptides: CHX35_RS15985_lanthipeptide

Lanthipeptides: CHX35_RS16000_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITSVSLCTPGCGDTGS+NS+CC

1

ITSVSLCTPGCGDTGSFNSYCC

22

86.4%

NZ_FNNQ01000006.1and 2 others:

NZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07685_lanthipeptideNZ_FNNQ01000006.1 Lanthipeptides: BLV90_RS07680_lanthipeptide

Lanthipeptides: BLV90_RS07690_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITSVSLCTPGCG+TGS+NS+CC

1

ITSVSLCTPGCGETGSFNSYCC

22

with 108 more sequence matches

Only the first 10 are displayed here.

81.8%

NC_006582.1and 6 others:

NZ_BOQQ01000001.1 Lanthipeptides: KI354_RS00530_lanthipeptideNZ_BOQS01000001.1 Lanthipeptides: KI364_RS00675_lanthipeptideNZ_CP019985.1 Lanthipeptides: BC8716_RS09795_lanthipeptideNZ_CP104963.1 Lanthipeptides: N7M99_RS07725_lanthipeptideNZ_FRBS01000002.1 Lanthipeptides: BUC05_RS08990_lanthipeptideNZ_JAODPB010000001.1 Lanthipeptides: N6H06_RS03040_lanthipeptide

Lanthipeptides: ABC_RS22115_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

TSVS CTPGCG+TGS+NSFCC

1

FTSVSFCTPGCGETGSFNSFCC

22

81.8%

NC_022873.1and 92 others:

NZ_CM000742.1 Lanthipeptides: BMYCO0001_RS26515_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18180_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18175_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18170_lanthipeptideNZ_CP011151.1 Lanthipeptides: WR47_RS18165_lanthipeptideNZ_CP015350.1 Lanthipeptides: BT246_RS19775_lanthipeptideNZ_CP015350.1 Lanthipeptides: BT246_RS19770_lanthipeptideNZ_CP015350.1 Lanthipeptides: BT246_RS19765_lanthipeptideNZ_CP017060.1 Lanthipeptides: FORC47_RS18710_lanthipeptideNZ_CP017060.1 Lanthipeptides: FORC47_RS18705_lanthipeptideNZ_CP017060.1 Lanthipeptides: FORC47_RS18700_lanthipeptideNZ_CP026678.1 Lanthipeptides: C2I25_RS21370_lanthipeptideNZ_CP026678.1 Lanthipeptides: C2I25_RS21365_lanthipeptideNZ_CP026678.1 Lanthipeptides: C2I25_RS21360_lanthipeptideNZ_CP035965.1 Lanthipeptides: EXW35_RS16385_lanthipeptideNZ_CP035965.1 Lanthipeptides: EXW35_RS16380_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16155_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16150_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16145_lanthipeptideNZ_CP035994.1 Lanthipeptides: EXW32_RS16140_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26195_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26190_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26185_lanthipeptideNZ_CP035999.1 Lanthipeptides: EXW27_RS26180_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16265_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16260_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16255_lanthipeptideNZ_CP036099.1 Lanthipeptides: EXW47_RS16250_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16620_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16615_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16610_lanthipeptideNZ_CP036117.1 Lanthipeptides: EXW43_RS16605_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16110_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16105_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16100_lanthipeptideNZ_CP036145.1 Lanthipeptides: EXW57_RS16095_lanthipeptideNZ_CP040334.1 Lanthipeptides: EUC39_RS14125_lanthipeptideNZ_CP040334.1 Lanthipeptides: EUC39_RS14120_lanthipeptideNZ_CP040334.1 Lanthipeptides: EUC39_RS14115_lanthipeptideNZ_CP045606.2 Lanthipeptides: GE376_RS18355_lanthipeptideNZ_CP045606.2 Lanthipeptides: GE376_RS18350_lanthipeptideNZ_CP045606.2 Lanthipeptides: GE376_RS18345_lanthipeptideNZ_CP047366.1 Lanthipeptides: GSN03_RS15835_lanthipeptideNZ_CP047366.1 Lanthipeptides: GSN03_RS15830_lanthipeptideNZ_CP071811.1 Lanthipeptides: EXW36_RS16415_lanthipeptideNZ_CP071811.1 Lanthipeptides: EXW36_RS16410_lanthipeptideNZ_CP071811.1 Lanthipeptides: EXW36_RS16405_lanthipeptideNZ_CP072061.1 Lanthipeptides: J5V93_RS15130_lanthipeptideNZ_CP072061.1 Lanthipeptides: J5V93_RS15125_lanthipeptideNZ_CP072061.1 Lanthipeptides: J5V93_RS15120_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15990_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15985_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15980_lanthipeptideNZ_CP084035.1 Lanthipeptides: LCF45_RS15975_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25975_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25970_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25965_lanthipeptideNZ_CP093291.1 Lanthipeptides: MN093_RS25960_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15810_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15805_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15800_lanthipeptideNZ_CP093835.1 Lanthipeptides: MN034_RS15795_lanthipeptideNZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24265_lanthipeptideNZ_JAIPUK010000008.1 Lanthipeptides: K9P71_RS24260_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06155_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06150_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06145_lanthipeptideNZ_JANCTB010000001.1 Lanthipeptides: NMG90_RS06140_lanthipeptideNZ_JH792114.1 Lanthipeptides: II3_RS21535_lanthipeptideNZ_JH792114.1 Lanthipeptides: II3_RS21530_lanthipeptideNZ_JH792114.1 Lanthipeptides: II3_RS21525_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11095_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11090_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11085_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11080_lanthipeptideNZ_JH792251.1 Lanthipeptides: III_RS11075_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18900_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18895_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18890_lanthipeptideNZ_LDGT01000041.1 Lanthipeptides: ABE17_RS18885_lanthipeptideNZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26430_lanthipeptideNZ_LDHL01000037.1 Lanthipeptides: ABD98_RS26425_lanthipeptideNZ_MOOL01000076.1 Lanthipeptides: BK733_RS27280_lanthipeptideNZ_MOOL01000076.1 Lanthipeptides: BK733_RS27275_lanthipeptideNZ_MOOL01000076.1 Lanthipeptides: BK733_RS27270_lanthipeptideNZ_MSTN01000016.1 Lanthipeptides: BVF97_RS28620_lanthipeptideNZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08145_lanthipeptideNZ_NIUP01000011.1 Lanthipeptides: CEU84_RS08140_lanthipeptideNZ_NKAX01000026.1 Lanthipeptides: CE086_RS26165_lanthipeptideNZ_NKAX01000026.1 Lanthipeptides: CE086_RS26160_lanthipeptideNZ_NVGU01000011.1 Lanthipeptides: COL71_RS14760_lanthipeptideNZ_NVGU01000011.1 Lanthipeptides: COL71_RS14755_lanthipeptide

Lanthipeptides: YBT1518_RS19670_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITS+S CTPGCG+TGS+NSFCC

1

ITSISACTPGCGNTGSFNSFCC

22

78.3%

NC_003923.1and 9 others:

NC_009641.1 Lanthipeptides: NWMN_RS09635_lanthipeptideNZ_CP023076.1 Lanthipeptides: CJ017_RS08945_lanthipeptideNZ_CP054876.1 Lanthipeptides: HUW54_RS09150_lanthipeptideNZ_CP077098.1 Lanthipeptides: KSF82_RS09475_lanthipeptideNZ_CP092781.1 Lanthipeptides: ML436_RS08940_lanthipeptideNZ_CP102959.1 Lanthipeptides: NW979_RS08780_lanthipeptideNZ_CP102962.1 Lanthipeptides: NW971_RS09555_lanthipeptideNZ_LR133917.1 Lanthipeptides: ELZ45_RS09155_lanthipeptideNZ_LS483317.1 Lanthipeptides: DQL75_RS09700_lanthipeptide

Lanthipeptides: MW_RS09420_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITS SLCTPGC TGS+NSFCC

2

ITSHSLCTPGCAKTGSFNSFCC

23

78.3%

NZ_CP047792.1and 1 other:

NZ_JAGSAY010000004.1 Lanthipeptides: KC186_RS06745_lanthipeptide

Lanthipeptides: E3S88_RS07345_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITS SLCTPGC +TGS+NSFCC

2

ITSHSLCTPGCANTGSFNSFCC

23

78.3%

NZ_LR134304.1:

Lanthipeptides: EL116_RS09245_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITSV CTPGCG TGS+NSFCC

2

ITSVIGCTPGCGKTGSFNSFCC

23

77.3%

NC_022873.1:

Lanthipeptides: YBT1518_RS19675_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

IT +S CTPGCG+TGS+NSFCC

1

ITRISACTPGCGNTGSFNSFCC

22

77.3%

NZ_AP019791.1:

Lanthipeptides: RxyAA322_RS06460_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITS SLCTPGC TGS+NS+CC

1

ITSYSLCTPGCAKTGSFNSYCC

22

77.3%

NZ_LELK01000004.1:

Lanthipeptides: AB986_RS12540_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITS S CTPGCG+TGS+NS+CC

1

ITSYSFCTPGCGETGSFNSYCC

22

70.8%

NZ_AP023356.1:

Lanthipeptides: Aiant_RS23765_lanthipeptide

1

ITSVSLCTPGCGDT--GSWNSFCC

22

ITSVSLCTPGC GS SFCC

1

ITSVSLCTPGCTSAGGGSQCSFCC

24

70.8%

NZ_VKCY01000012.1:

Lanthipeptides: FNK43_RS09020_lanthipeptide

1

ITSVSLCTPGCGDTGSWNSFCC

22

ITS SLCTPGC TGS+NS+CC

3

ITSFSLCTPGCAKTGSFNSYCC

24

MIBiG 4.0 matches for KM925_RS26245

29.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

ITSVSLCTPGC

11

ITS+SLCTPGC

1

ITSISLCTPGC

11

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.97 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

Additional weak hits (2):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.23 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 36.53

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

KM925_RS26245 - Class I

Cleavage pHMM score: 13.90

RODEO score: 31

Monoisotopic mass: 2064.9 Da

Molecular weight: 2066.4 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2084.4 Da N = 1; 2102.4 Da N = 2; 2120.4 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 164 - 258; Score: 56.1

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAHHYI010000001.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 420,946 - 441,842 nt. (total: 20,897 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

KM925_RS02230: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

KM925_RS02255: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

KM925_RS02260: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001075.5	0.38	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001075.5	0.38	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

KM925_RS02255: PT_FPPS_like

Domain 1 (35 - 297): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06

Confidence: medium

Additional weak hits (3):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.34 out of 31.73

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.65 out of 32.93

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.60 out of 39.62

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_JAHHYI010000001.1 - Region 2 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 812,419 - 846,994 nt. (total: 34,576 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

KM925_RS04160: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

KM925_RS04220: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: aminotransferase formyltransferase

KM925_RS04150: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

KM925_RS04200: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

KM925_RS04240: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Lyases: decarboxylase

KM925_RS04205: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: synthase

KM925_RS04260: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002683.2	0.66	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002633.2	0.65	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0001478.5	0.61	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3	0.59	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002469.2	0.59	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002692.2	0.59	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001531.5	0.59	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.57	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002470.2	0.57	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002683.2	0.66	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0002633.2	0.65	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0001478.5	0.61	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001572.3	0.59	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002469.2	0.59	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002692.2	0.59	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001531.5	0.59	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.57	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002470.2	0.57	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.42 out of 26.06

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.24 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.13 out of 27.78

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.77 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.43 out of 29.38

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.42 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.32 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.00 out of 27.78

Confidence: medium

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.86 out of 26.12

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (6):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.93 out of 30.11

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.04 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.14 out of 32.74

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.27 out of 25.88

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.99 out of 20.01

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
LuxO	Repressor of luminescence
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 1	Zinc-responsive repressor

NZ_JAHHYI010000001.1 - Region 3 - terpene

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Location: 1,003,768 - 1,024,586 nt. (total: 20,819 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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MIBiG comparison

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: hydratase

KM925_RS05150: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000537.3	0.39	ribosomal	nisin U	Streptococcus uberis
BGC0000539.5	0.38	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000487.5	0.36	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000523.3	0.35	ribosomal	lactocin S	Lactobacillus sakei
BGC0002064.2	0.35	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0000548.4	0.34	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000520.5	0.34	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000188.5	0.33	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001561.4	0.33	NRPS	curacomycin	Streptomyces curacoi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000537.3	0.39	ribosomal	nisin U	Streptococcus uberis
BGC0000539.5	0.38	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000487.5	0.36	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000523.3	0.35	ribosomal	lactocin S	Lactobacillus sakei
BGC0002064.2	0.35	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0000548.4	0.34	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000520.5	0.34	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000188.5	0.33	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0001561.4	0.33	NRPS	curacomycin	Streptomyces curacoi

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

KM925_RS05180: PT_phytoene_like

Domain 1 (15 - 208): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.37 out of 27.78

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.22 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19

Confidence: medium

Additional weak hits (5):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.84 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 27.39 out of 36.54

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.71 out of 32.93

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.43 out of 28.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_JAHHYI010000003.1 - Region 1 - T3PKS

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Location: 138,902 - 179,987 nt. (total: 41,086 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KM925_RS12025: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: acetyltransferase methyltransferase

KM925_RS12010: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

KM925_RS12020: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: glucosidase

KM925_RS12090: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: synthase

KM925_RS12015: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter

KM925_RS12065: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002285.2	0.53	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001310.5	0.53	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001962.3	0.49	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001810.3	0.41	PKS	trehangelin	Polymorphospora rubra
BGC0002656.2	0.41	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0000495.5	0.41	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002285.2	0.53	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001310.5	0.53	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001962.3	0.49	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001810.3	0.41	PKS	trehangelin	Polymorphospora rubra
BGC0002656.2	0.41	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0000495.5	0.41	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.15 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.72 out of 27.78

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.15 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.74 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.70 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.54 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

Additional weak hits (2):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.26 out of 31.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.51 out of 32.74

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_JAHHYI010000003.1 - Region 2 - phosphonate

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Location: 811,464 - 828,889 nt. (total: 17,426 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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MIBiG comparison

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TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase oxidoreductase

KM925_RS15220: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

KM925_RS15250: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

KM925_RS15270: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: aminotransferase

KM925_RS15265: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.48	other (other)	dehydrophos	Streptomyces luridus
BGC0001859.4	0.47	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.5	0.46	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002036.4	0.46	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0001739.3	0.44	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0002670.2	0.41	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000926.5	0.41	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000841.5	0.39	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000937.5	0.39	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000938.5	0.37	other (aminocoumarin)	fosfomycin	Streptomyces fradiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.48	other (other)	dehydrophos	Streptomyces luridus
BGC0001859.4	0.47	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0000904.5	0.46	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002036.4	0.46	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0001739.3	0.44	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0002670.2	0.41	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000926.5	0.41	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000841.5	0.39	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000937.5	0.39	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000938.5	0.37	other (aminocoumarin)	fosfomycin	Streptomyces fradiae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.86 out of 27.78

Confidence: medium

Additional weak hits (1):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.77 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAHHYI010000003.1 - Region 3 - terpene

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Location: 952,664 - 969,567 nt. (total: 16,904 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KM925_RS15920: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

KM925_RS15950: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

KM925_RS15955: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: aminotransferase

KM925_RS15915: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: glucosidase hydrolase

KM925_RS15930: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

KM925_RS15960: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.63	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000647.3	0.58	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.5	0.47	terpene	β-carotein	uncultured bacterium
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0000640.3	0.46	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000650.3	0.45	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0000885.3	0.44	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000648.3	0.43	terpene	carotenoid	Myxococcus xanthus
BGC0001374.5	0.43	other (other)	thienodolin	Streptomyces albogriseolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.63	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000647.3	0.58	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.5	0.47	terpene	β-carotein	uncultured bacterium
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0000640.3	0.46	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000650.3	0.45	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0000885.3	0.44	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000648.3	0.43	terpene	carotenoid	Myxococcus xanthus
BGC0001374.5	0.43	other (other)	thienodolin	Streptomyces albogriseolus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

KM925_RS15945: PT_phytoene_like

Domain 1 (6 - 281): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.38 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.89 out of 20.97

Confidence: medium

Additional weak hits (1):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.99 out of 20.01

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JAHHYI010000004.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 116,837 - 138,714 nt. (total: 21,878 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

KM925_RS16570: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase

KM925_RS16620: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

KM925_RS16635: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000527.5	0.40	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000557.5	0.40	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.40	ribosomal	suicin 65	Streptococcus suis
BGC0000547.5	0.39	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000545.5	0.39	ribosomal	ruminococcin A	[Ruminococcus] gnavus E1
BGC0000550.3	0.38	ribosomal	salivaricin G32	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000527.5	0.40	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000557.5	0.40	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.40	ribosomal	suicin 65	Streptococcus suis
BGC0000547.5	0.39	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000545.5	0.39	ribosomal	ruminococcin A	[Ruminococcus] gnavus E1
BGC0000550.3	0.38	ribosomal	salivaricin G32	Streptococcus salivarius

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

KM925_RS16615: T2TS

Domain 1 (3 - 624): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.48 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.33 out of 20.97

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 24.74 out of 26.33

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16

Confidence: strong

Additional weak hits (1):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.13 out of 29.72

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
ToxT	Regulator of MSHA biosynthesis