LOCUS       NZ_JAHHYI010000015     26451 bp    DNA     linear   CON 30-AUG-2024
DEFINITION  Priestia megaterium strain 179-F 3A1 HS
            NODE_15_length_72748_cov_49.839289, whole genome shotgun sequence.
ACCESSION   NZ_JAHHYI010000015
VERSION     NZ_JAHHYI010000015.1
KEYWORDS    WGS; RefSeq.
SOURCE      Priestia megaterium (Bacillus megaterium)
  ORGANISM  Priestia megaterium
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Priestia.
REFERENCE   1  (bases 1 to 72748)
  AUTHORS   Wood,J.M., Hendrickson,R., Singh,N.K., Bateh,J., Peres,J.B.,
            Aronson,H.S., Mason,C.E. and Venkateswaran,K.
  TITLE     Draft Genome Sequences of Sporulating Bacteria Isolated from a
            Spacecraft Assembly Facility
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 72748)
  AUTHORS   Wood,J.M., Hendrickson,R., Singh,N.K., Bateh,J., Peres,J.B.,
            Aronson,H.S., Mason,C.E. and Venkateswaran,K.
  TITLE     Direct Submission
  JOURNAL   Submitted (27-MAY-2021) Biotechnology and Planetary Protection
            Group, Jet Propulsion Laboratory, California Institute of
            Technology, 4800 Oak Grove Dr., Pasadena, CA 91109, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 24-SEP-2020
            Assembly Method                   :: SPAdes v. 3.11.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 198.49x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_019037625.1-RS_2024_08_30
            Annotation Date                   :: 08/30/2024 04:30:47
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,420
            CDSs (total)                      :: 6,353
            Genes (coding)                    :: 6,249
            CDSs (with protein)               :: 6,249
            Genes (RNA)                       :: 67
            rRNAs                             :: 3, 4, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 3 (5S)
            partial rRNAs                     :: 4, 2 (16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 10
            Pseudo Genes (total)              :: 104
            CDSs (without protein)            :: 104
            Pseudo Genes (ambiguous residues) :: 0 of 104
            Pseudo Genes (frameshifted)       :: 32 of 104
            Pseudo Genes (incomplete)         :: 71 of 104
            Pseudo Genes (internal stop)      :: 23 of 104
            Pseudo Genes (multiple problems)  :: 19 of 104
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:31:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1533
            Orig. end                         :: 27984
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHHYI010000015.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26451
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26451
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26451
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16451](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16451)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     tRNA            580..651
                     /anticodon=(pos:2146..2148,aa:Cys,seq:gca)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="KM925_RS26180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="KM925_26175"
                     /product="tRNA-Cys"
     gene            580..651
                     /locus_tag="KM925_RS26180"
                     /old_locus_tag="KM925_26175"
     gene            679..2100
                     /locus_tag="KM925_RS26185"
                     /old_locus_tag="KM925_26180"
     CDS             679..2100
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127292.1"
                     /locus_tag="KM925_RS26185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26180"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_013060067.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.1e-47, bitscore:
                     153.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTSMTIITTLLICFCFTNYGHAKTETNQYYTVILKDRSKWTQS
                     IKKIKKSQGEITYTVPEIGLIQFKGNQKVAKTNASLFKSLSPSLKLEKPSTSTSKSFKK
                     PNSSVNSIKGLDSTLPALWDMQWDMKEITHNGESYNIESGSSNVTVGIVDSGIDIDHPD
                     LVDNLKSGSKNLVPKGGLRGTEPEETGDINSINDINGHGTMVAGSIAANGEIKGVAPNT
                     GIKVYRVFGNKSADAVWIIKAIIQAAKDDVDVINLSLGSYYIDGNIYKDGELLDNKWAD
                     VEGYKLAIEYANKLGSVVVASAGNDSIDVSNKSELNDFLKKKYAEEGKTFNGVGIEAPG
                     ELPGVVTVSSTGPTQQLSLFSNFGKNYIDIAAPGGDSRLLEKYGQEAWWDGGLFRQEQV
                     LTTFNTGRYLFASGTSMAAPKVSATLALIIDQRHYKNRPSNSIDYLYKNGVKKDIEPNL
                     AYWGNGQLDVYNAVK"
     gene            complement(2136..3563)
                     /locus_tag="KM925_RS26190"
                     /old_locus_tag="KM925_26185"
     CDS             complement(2136..3563)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060068.1"
                     /locus_tag="KM925_RS26190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26185"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_197227409.1"
                     /transl_table=11
                     /translation="MIKRLSLKNQFILTFASVIFLSLISTICSLVLLYYFLSVYNEKSV
                     QPANYYEKKVPSIEKFVELKGEKILEVSFQKNLEKVIPTEGITYQVINLRGNKIYGTLD
                     DQLIENNKSIYEKVNRSDQKGKVITKYLPILDKNRMEGVLAVRYVLASSIDYYIKYIFL
                     IILLIPFLFLTLYSYVFARRFGKELNKPIKELSAASQKIKNQDLDFEIKYESENEIGVL
                     IDSFNSMKEELKTSLYLQWKLEQERRDMVASIAHDLRTPLTIILSHVEVLMDPSLNGQK
                     RLPQYLQTIKNNTQRVLHLTEEMKRVSEVDNPDFTLDIEGVIPIEMLPEMLEEFKKWAE
                     DEEIKFTYSLNRKPGEGNSEFALDPKRLHQILTNLISNSIRFTPVNGSIDVQVQIEKDM
                     MSFSISDTGKGFDTKDLPFLFSKFYQGDPSRNDQLHHGLGLYIVKELVIKHGGEIHARN
                     NEPQGACIEFTISSINK"
     gene            complement(3563..4243)
                     /locus_tag="KM925_RS26195"
                     /old_locus_tag="KM925_26190"
     CDS             complement(3563..4243)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060069.1"
                     /locus_tag="KM925_RS26195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26190"
                     /product="response regulator transcription factor"
                     /protein_id="WP_013060069.1"
                     /transl_table=11
                     /translation="MQESILVVDDELEIVDIISDIFEDRGYRVLKAYNGEQALDQLKTN
                     VDLIILDVMMPQMDGFDLCKVIREQIYCPILFLSAKHSEMDKVKGFTLGGDDYITKPFQ
                     VKELIARVEAHLRREQRDRVSTQNQRLLGNLTINYSQHDVLLDGKKIDLTSKEFKILEL
                     LTVNLGQIFSKEQIYEKIWGIDAMGDLNTIIVHINNLRAKLTSGMSTYHIKTVWGVGYK
                     LEKR"
     gene            complement(4327..6168)
                     /locus_tag="KM925_RS26200"
                     /old_locus_tag="KM925_26195"
     CDS             complement(4327..6168)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1243: ABC
                     transporter, permease component"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060070.1"
                     /locus_tag="KM925_RS26200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26195"
                     /product="FtsX-like permease family protein"
                     /protein_id="WP_216885240.1"
                     /transl_table=11
                     /translation="MISMWKYITKNITRNLSHYTVYILSSILSVAIFYMYAAFLLYPKV
                     SGTEQLLIACEIIILLFSCFFIAYSHEHFLRERKKEMGIWKTFGASRKQLFNVLVLENA
                     VVGTFSILVGILFGMLLSKIFFNFMSDILFSNQSFVYTFSPVAVFVTVILFGIVFLLVS
                     CRSYFKIKRIAVLELFQEEKKPKPSAQFSRVKFILSICFLLVSYIFISYASLPMLLFAF
                     LPLLALLLVGTYLFCSNGLVGVISYLNNKEKRQLNGIKMLTLISLRKRLYYNAKIIFIV
                     SILLSAIMISIGAIQLYIEKNSQRMQSTHPQGALFVASKGKENKIEDIIAELKRQGIKD
                     LHMNKWKGLKISSESGKKQFLVIQNDPSFIKDEDSLKNNNYIFNNKKTDDITNEILKLK
                     FEKGERDLKVKNMNGKRVLNPIDGIEGIISVPKNTFSEIYKTTISEKRLSLYKLDFKED
                     AKIYNILKKLSDTTLFKSDNLHSIRLLDYENTVQLSSILRLTGLFICLVLFLALASLLW
                     FKLYEDMNDDKKVFHSLRKVGLTAKEIKRTLYIQISVIFFVPLSLGGLNLFIATNALQN
                     ILEGITIYSIIVIFLIFGVSQFIIYLISSYFYSKKVL"
     gene            complement(6140..6919)
                     /locus_tag="KM925_RS26205"
                     /old_locus_tag="KM925_26200"
     CDS             complement(6140..6919)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060071.1"
                     /locus_tag="KM925_RS26205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26200"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_029321001.1"
                     /transl_table=11
                     /translation="MAILEAREITKVYKTKYRTYPVLKNISLDIEEGDFVAIMGPSGSG
                     KSTLLNVLSSLDIPSEGDIKVGGTTLTGMKEEQLGIYRREHIGFIFQNYNLLDHLTIEE
                     NILLPAALKKGDKKGVQNKLQKFAEELEVTKFLTKYPYEVSGGQQQRAAIIRALINNPA
                     LLFADEPTGNLDSKSAQNVLHTLKMLNEKYKTTILMVTHDSVAASFCNRVIFLKDGQIV
                     HEMKRSKLEDTSKFNQRILSFIAKEVEDNDINVEIYN"
     gene            complement(6944..7705)
                     /locus_tag="KM925_RS26210"
                     /old_locus_tag="KM925_26205"
     CDS             complement(6944..7705)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060072.1"
                     /locus_tag="KM925_RS26210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26205"
                     /product="ABC transporter permease"
                     /protein_id="WP_013060072.1"
                     /transl_table=11
                     /translation="MKALFISEWERLWSQRKSKWMIGIFTVIVLLQAWFLRYYGVGIYN
                     NDQQVPLNTWNFPWFLLKESSFLLTLIFMPVFFLNSLNVEYNSGAYRLFLIRPFKRKSF
                     LISKWFSLALMVLVHLLIILGISIAFGFIFLKPDNDFTFYGQQKNAIEAILYTVQVYGL
                     FFIIQMCCLALASLISVIISNAVISFFLLIGLYVGCLYVSSQLSFFLLSVQSIFHTLST
                     TSNSLYVFAFVIMLVGFGACVRIWSKKEFTS"
     gene            complement(7723..8553)
                     /locus_tag="KM925_RS26215"
                     /old_locus_tag="KM925_26210"
     CDS             complement(7723..8553)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161130.1"
                     /locus_tag="KM925_RS26215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26210"
                     /product="ABC transporter permease"
                     /protein_id="WP_013060073.1"
                     /transl_table=11
                     /translation="MKGLFTSELERLWSQKISWIILFFIPLMSLGSVKYYLNWNERVSP
                     GQPDYVTSLNFPIISISEHLVVSFNIIAIILISTVIANEIENGQLRMILIRPFSTTQLF
                     LAKLATILTTMFLYLTLFWILNTVAGYIFFPKVNTLITFLDEQKLSLAAALLYNVKYFF
                     ACFVTMISVVSVFTLLGSISRSTMITLGAGVGFIFLAIAIPQLLEFSTQTIIGHSTVVH
                     LMYMSIVKIQHTGIAFLLSSTNNLNSYIILVQAVYIALFGLIGYWTFVKRDYFI"
     gene            complement(8550..9284)
                     /locus_tag="KM925_RS26220"
                     /old_locus_tag="KM925_26215"
     CDS             complement(8550..9284)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001058380.1"
                     /locus_tag="KM925_RS26220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26215"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013060074.1"
                     /transl_table=11
                     /translation="MKKEIVLEANNITKTVSGKNIVSQFSTKVYKGDICGFLGPNGAGK
                     TTVMRMFTGLIRPTQGTIMVGGKDVNKDRQQALRNVGAIIESPIFFPYMSGRKMLQNLA
                     RLYPDLSRKEQLEQVEAALSVVRLTEDADVKIKNYSLGMRQRLGIAQALLGEPDVILLD
                     EPANGLDPMGMRELRELILELREKKNLTFFISSHLLDEIQQMCDHLVIIRNGKLVTQGS
                     KEELIKDPSKRLEDVFVEMMTS"
     gene            complement(9371..9976)
                     /locus_tag="KM925_RS26225"
                     /old_locus_tag="KM925_26220"
     CDS             complement(9371..9976)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060075.1"
                     /locus_tag="KM925_RS26225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26220"
                     /product="flavoprotein"
                     /protein_id="WP_216885241.1"
                     /sec_met_domain="Flavoprotein (E-value: 7.6e-34, bitscore:
                     108.7, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVKNIVEKKILVGVSGSIAVAGIFQYLAMLKANFSEVKVVMTKG
                     AVQLIPAETVKLYCDEVFIDEKLSISGTIGHVELARWSDLMAVLPATGNTLSKAAHGLA
                     TDLLSTVILAHDKPVIFFPNMNKLMWEKKVVQHNVKLLQQYDHIVVPPVKTTAFEIATM
                     SLRPNYVLPNPQNILNIISKQLEERNRLANICEKVEVQ"
     gene            complement(10001..11359)
                     /locus_tag="KM925_RS26230"
                     /old_locus_tag="KM925_26225"
     CDS             complement(10001..11359)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001177658.1"
                     /locus_tag="KM925_RS26230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26225"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_216885242.1"
                     /sec_met_domain="LANC_like (E-value: 1.3e-71, bitscore:
                     233.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSTTDQKTYWLKGIDNETRNKALKLVLSIAEKLKDPSGIEKIVM
                     APDNVSLAGNLNPWDPITLSHGFPGTILLFGELDRQFPDSGFDLVAHNHLVEVQKVIER
                     QGVNSISMFGGITGVAYATLYISHNYERYSRFLQVLNNFILMQLEKILNEPEKELGVHP
                     LKYDVIQGMTGIGRYLIENTKHKENHEALKKILTYFVDMASDIEVNGEKVPGWYVSKAN
                     QLLEKDRIMFPEGNFNCGLAHGIPGPLSFMALSIQKGIEIPGQREAVLKITNWLMKWKQ
                     VDSGWPSRLSFQEVATSKISHSYPKRQGWCYGDPGVARSIYLAGKALGDTAAIRSAVGA
                     YQDIIVEPKEEWELVSPTFCHGRAGLLQMLIRMAKDEENQISVQSIVELVHYIEESYDA
                     NAPFGFRDIESNGEKSHQLNKAGLLEGVTGVLLPLLSLSSVEEPWWDGAFLLS"
     gene            complement(11384..13267)
                     /locus_tag="KM925_RS26235"
                     /old_locus_tag="KM925_26230"
     CDS             complement(11384..13267)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060077.1"
                     /locus_tag="KM925_RS26235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26230"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_013060077.1"
                     /transl_table=11
                     /translation="MKNTLDPTMENEKVSFVSILKSFRYWPSLFKLLWETHRGYFFCVL
                     VLNFLNGLLPASLILAIKYLVNMVQNLYIQGYKDNYFYDILPFFIFFSVVTLLTSATGS
                     ILETHKQLYRNLLSNKINVKLIEKAKRLPYASFENPEVYNKLQRARQDSTYKPFAIFEE
                     LMGIVKGAITLISISIILMVWNWEFTLILILLPLISAWSIVNVGKEIFLVSHKRAEETR
                     KQFYYYYLMTTDITVKEVKIFGLGSLLLRNYSDLFSKFYNQDRHLLLKKMRIDLSFQLI
                     SVIFVIFVQFMIVKDTIQGLIAIGSLIAYFQAVNTTQKTSNELMYMVFNMHQNNLYMTQ
                     LFSFLNVPESTDKPNVSEEKTLENVSSTEEGIQFLNVSFKYPGQENYTLKNVNFHIKPG
                     ETLALVGSNGSGKSTIVKLLTRLYTDYEGIILLNGKRIEDYQPQDWQDRISAIFQDFVR
                     YELDVKENIGYGDYKRSNHLVAIQAAAKRSGALTMIDSLPDKMDTQLGKTFANGIQLSG
                     GQWQRIAIARAYMRRASLYILDEPTAALDPAAEEEVFQDFQEIAQKSMGLFISHRYSTV
                     KYADRIIVLDKGEVAEYGTHVELLDTNGIYARLFNLQAKSYIEASATQASS"
     gene            complement(13233..16451)
                     /locus_tag="KM925_RS26240"
                     /old_locus_tag="KM925_26235"
     CDS             complement(13233..16451)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060078.1"
                     /locus_tag="KM925_RS26240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26235"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_216885243.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1e-172, bitscore:
                     567.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2e-17,
                     bitscore: 56.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.3e-43, bitscore:
                     142.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILQKEKFNYKSSVTTENNLFEPLPFFMLRAPFLPTHTFDQLKDE
                     AVLVEKLRAYAEKDYVKEAIAIASPSLLNSLHYIHGDLNNRKTQQVLSSMLRYMLRMTT
                     RPTPFGAFSGVAAGQFKKNSSLKIDHFKEFKKRARPDMEWLLGVISVLERSNILPSLIV
                     DKNRASYVVGDRLHLPFSTECGQLRKKGMEKRENISIIYSEVVEKVLNLAEERITVREI
                     TQRLHTIYPNTDVTIIQRFIIQLLEQEYLITELRPPLTIDNPFNYLIRKLEEKDEKIEL
                     YEELLKVRELINTYNQLPLGEGLSLYSDLISQMRHIYEVTTPLQVDFSLNATDLTIGEK
                     VGEDISKAAQILWSIADEGVGFPHLQKYHVDFLEKYGTSREVPLLELLSEELGLGAPAS
                     YQNPHGKRGGDTTTSSINQERNSQLSYLLIKAIHNQEKEIEITEEIAQRMSKEKDRRYA
                     PDSLEVYGELHAASQEDLDQGNYTFCLSPNPGSNALGSTFGRFLDILDPDVSLKIQQYQ
                     QKIDLEFNEDTVMVEGSFLPATGRSANVAIGKTTRKVNVTLGTNGDEETIQLPIDDIVV
                     GASLENFYMKSKKLGKRIKVVAGNMLNYQSAPNIYRFMREISLNDLDQWRPFNWGSMAH
                     SPYYPRIRYKNIVISPSIWKLNKEVFGMREKPQNEEEFFKAFGEWREKWSVPRNVFMTY
                     GDNRILIDLENTLHLRELKNELFKQGRLQLRETLQDRDQNCLNSPLGRHAVEIVVPLKK
                     TENTERRKKIGAIGEAKKDIVSNKIIYKLPGSEWLYVKLYAPNARENDLILKYLTPFAS
                     EMVKSDMASSWFFMRYRDPDAHIRLRFQGDPSKLSGLVLPRLREWADKLMDLGLLQKIT
                     IDTYEREVERYGGPMLIEKAEDYFHYDSQSVAMILSTLNQQNHLSAYVMASLSIIDIMD
                     NFGLNYAQQVASIENNTEKYEYIDEFRPLRKELSLIGDSRNDWENLRNYNSGVGKSIYE
                     SFLIRKESLTRYVTEIKELQKRDMLWNEHQMIMGAIIHMYCNRLLGANRELEKKALAFT
                     RHILSSQKYWRNKNEEYARSYNGK"
     aSDomain        complement(15678..15959)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KM925_RS26240_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.00E-18"
                     /identifier="RREFam001.1"
                     /label="KM925_RS26240"
                     /locus_tag="KM925_RS26240"
                     /protein_end="258"
                     /protein_start="164"
                     /score="56.1"
                     /tool="antismash"
                     /translation="KNRASYVVGDRLHLPFSTECGQLRKKGMEKRENISIIYSEVVEKV
                     LNLAEERITVREITQRLHTIYPNTDVTIIQRFIIQLLEQEYLITELRPP"
     gene            complement(16537..16677)
                     /locus_tag="KM925_RS26245"
                     /old_locus_tag="KM925_26240"
     CDS             complement(16537..16677)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_b"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000606628.1"
                     /locus_tag="KM925_RS26245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26240"
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_013060079.1"
                     /sec_met_domain="TIGR03731 (E-value: 7.2e-20, bitscore:
                     63.1, seeds: 23, tool: rule-based-clusters)"
                     /sec_met_domain="mature_b (E-value: 2.2e-10, bitscore:
                     32.8, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNVKNLFDLDVQVTTASSDVDPQITSVSLCTPGCGDTGSWNSFC
                     C"
     CDS_motif       complement(16606..16677)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNNVKNLFDLDVQVTTASSDVDPQ"
                     /locus_tag="KM925_RS26245_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16537..16605)
                     /prepeptide="core"
                     /locus_tag="KM925_RS26245_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="13.90"
                     /molecular_weight="2066.4"
                     /monoisotopic_mass="2064.9"
                     /core_sequence="ITSVSLCTPGCGDTGSWNSFCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNNVKNLFDLDVQVTTASSDVDPQ"
                     /leader_location="[16605:16677](-)"
                     /alternative_weights="2084.4"
                     /alternative_weights="2102.4"
                     /alternative_weights="2120.4"
     gene            16901..17074
                     /locus_tag="KM925_RS26250"
                     /old_locus_tag="KM925_26245"
     CDS             16901..17074
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001030236.1"
                     /locus_tag="KM925_RS26250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26245"
                     /product="hypothetical protein"
                     /protein_id="WP_013060080.1"
                     /transl_table=11
                     /translation="MTKTLWNFLMEMKKNNLTFENYELCPSLNALSPEEKVVLNEYARS
                     LVLENEVGNEWV"
     gene            17061..18023
                     /locus_tag="KM925_RS26255"
                     /old_locus_tag="KM925_26250"
     CDS             17061..18023
                     /EC_number="2.5.1.-"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060081.1"
                     /locus_tag="KM925_RS26255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26250"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_053488454.1"
                     /transl_table=11
                     /translation="MNGFRSDLIDHINQHLSSYKQSGRAEVDLLALKHLSKRGKLLNQE
                     LSGFSWGELYLTLSYFLKRRKMTEEDFEKAFGIECIFLSADIVDDICDLDDPNLPTFQN
                     EDRYLILISQYLLAKGFFYLRPVSDSYEDNCLFSLIMDSGCGEWKDLHFRFSINKRVIP
                     TEEEYFKLIKQKSGKLTEIISQAIDPSQLILKKITYYIGIAGQLRNDAADVLNDKKSDL
                     RDLKAYLPFLKAYEYSCEVQDEFFHKLKDEEIMTSPLKRQLIREYIEQSGSIDYCHILS
                     RFYYMRAFKLLEEHFKLSKKEMNYFKSLFLQRSQQHEQA"
     gene            18010..20160
                     /locus_tag="KM925_RS26260"
                     /old_locus_tag="KM925_26255"
     CDS             18010..20160
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013060082.1"
                     /locus_tag="KM925_RS26260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26255"
                     /product="sensor histidine kinase"
                     /protein_id="WP_013060082.1"
                     /transl_table=11
                     /translation="MNKHNLLICLPLGTLYIIIFMANGYYLYLSDFRRFVDSATLNSFY
                     VTSVISLIFFSIGLFSFFKKQKSIVIKNFFLLTSVSGIAISTSVLSSQDIPVFKTIEII
                     SVFMLSYLLLSFFAHFPVSTKPNYVKIIIFSSLLFSTLSSVVYLICNYLGYVEHSKFFY
                     IYRVLLIGNLFFSIVGCIFLISLHLKTNSLKVRNQLYILIFGIVFSFGPLFLFNLIPGM
                     IFGESQIPFVYCLPSIIVFPLTTSYLLVKHEIIEVELEISKWINILIYYILNFLLFSIL
                     IKQFMHLSNRELFVICSVGLLSAWASIFLYKIGINTFIQKKTKNRENTDLNEIELFQTL
                     SKEKHAKNLAKIIGKVIHQKFDINGLCIVWNSNNIYHSLHETGIFQTMNQFNFLNEINK
                     LEKDILLVEDQTPSIHMHFEKYHLICFPIAINQLVQGVIVIGEKNNHTLFQGKEFIELK
                     ELICESADILSSAAILNINDKQIRRTKTRVQNWNQFNHQVIQSLEKERKRLSIFLHDEI
                     LQSLILQLNEVRIMQTKRNFSVTLLDEMDDQLEGMIYNIRKMCHDLHPIIVEDLGLEPS
                     LQSLKREFELNYSILIHVQFNCEFKIISKNHEIQVYRIIKELLNNAVKHSKGKNIKVLI
                     LEENGFYQCSVKDDGIGFDVPDNFFDFSKGNHLGLLTIHRQIAELNGSMRISSDKGQGT
                     FVTFTIPLDWEDKNEYTYATSG"
     gene            20132..20740
                     /locus_tag="KM925_RS26265"
                     /old_locus_tag="KM925_26260"
     CDS             20132..20740
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002128205.1"
                     /locus_tag="KM925_RS26265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26260"
                     /product="response regulator transcription factor"
                     /protein_id="WP_013060083.1"
                     /transl_table=11
                     /translation="MSIRTLLVDDHLLVMLGIRRLLESEEDIEIIDTVSDPSSLIEVVA
                     TTSPDVVVTDVRMKEFNGIELTKELLSKFPEIKVVILSGYDHEEYYNAAFKAGASAYIT
                     KERSAFDLANAIRQSNMGYILFSKNQISTKDFETLTSAEQKILLLISKDKTNYEISMDL
                     SISKRTVEYHISSIIRKLDVDSRVGAVVKGIKKGLIEDF"
     misc_feature    complement(20851..20869)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 22.23"
                     /tool="antismash"
     misc_feature    complement(21799..21813)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 23.97"
                     /tool="antismash"
     gene            21907..22131
                     /locus_tag="KM925_RS26270"
                     /old_locus_tag="KM925_26265"
     CDS             21907..22131
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KM925_RS26270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KM925_26265"
                     /product="hypothetical protein"
                     /protein_id="WP_216885244.1"
                     /transl_table=11
                     /translation="MISIKKAVCTHYGIRMDVFKPEEIISFNHMHSRGYFTCPYCGDIE
                     ITHECQEGKSRFVVAANRDHTHDCLYKES"
     misc_feature    22242..22260
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            22494..22766
                     /locus_tag="KM925_RS26275"
                     /old_locus_tag="KM925_26270"
     CDS             22494..22766
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0030261 - chromosome condensation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1132: DNA-binding
                     protein HU 1"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013055305.1"
                     /locus_tag="KM925_RS26275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26270"
                     /product="HU family DNA-binding protein"
                     /protein_id="WP_216885245.1"
                     /transl_table=11
                     /translation="MNKTELVDAVATKSELTKQDSKKAVDALFETISNTLAKEEKIQLI
                     GFGTFEIRERAERTGRNPQTGEEMTIPASKAPAFKPGKELKDAFK"
     gene            complement(23332..23505)
                     /locus_tag="KM925_RS26280"
                     /old_locus_tag="KM925_26275"
     CDS             complement(23332..23505)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KM925_RS26280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KM925_26275"
                     /product="hypothetical protein"
                     /protein_id="WP_216885246.1"
                     /transl_table=11
                     /translation="MKNQSNNSKPAIGDDRFNTAGYTSDEANVNDVHGKHLSSFKDKVF
                     TSEKEDASSTKS"
     misc_feature    23649..23663
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 24.13"
                     /tool="antismash"
     gene            complement(23903..24340)
                     /locus_tag="KM925_RS26285"
                     /old_locus_tag="KM925_26280"
     CDS             complement(23903..24340)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KM925_RS26285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KM925_26280"
                     /product="DUF3888 domain-containing protein"
                     /protein_id="WP_216885247.1"
                     /transl_table=11
                     /translation="MKKLLFLTFLIIFLTFNSQIVANAEQGYEESPLNTKETYDNFMIS
                     LLSEKLTESMNEHYGKSLVGYKRTSENFIKIQQFIKENTEERSMRNIKYVVTFSLSPVI
                     EEKGKQVTEGTDIIQFEVLTDYLDEGDTDKGVKLIKYQQHK"
     gene            complement(24501..25112)
                     /locus_tag="KM925_RS26290"
                     /old_locus_tag="KM925_26285"
     CDS             complement(24501..25112)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025636.5"
                     /locus_tag="KM925_RS26290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26285"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_216885248.1"
                     /transl_table=11
                     /translation="MINKKVDPRVQRTQNLLRDALIELIDEKTYEKITIQDITTRATVN
                     RATFYRHFLDKDELLNQSIDKMLKELFGEASKFYSVSKNVDELQKYVASHIFEHIARHK
                     KFFQVMLIGKGIPNFIHYLKEFLFEFYDHAISEANLVENELPVAKEMVVSYISAAYIGV
                     ISWWLENDMLESPSSMAQQMIQINTQGPIQLLKKYQKPES"
     gene            25415..26155
                     /locus_tag="KM925_RS26295"
                     /old_locus_tag="KM925_26290"
     CDS             25415..26155
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016107144.1"
                     /locus_tag="KM925_RS26295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KM925_26290"
                     /product="acetoacetate decarboxylase"
                     /protein_id="WP_216885249.1"
                     /transl_table=11
                     /translation="MQQDEVIKQFTTPLGAPAFPVGPYRFHNREYLNILYRTDIDSLRK
                     IVPEPLEITDPLVRFEIMKMPDVTGLGSYTECGQVIPVSFNGEEGEYLHAMYVDSHPAI
                     ASGREIGAYPKKLGKPSLFVDSDTLVGTLDYGSLRVATATMGYKHCPLDLSEARKEICK
                     PSYMIKKMPGYDGYPRICELVRSQITDITIHGAWSGPARLELFAHALAPMSDLPVYEVV
                     STSHILTDLTLASPRVVHDYLASK"
ORIGIN
        1 cttcttggga tgcattctat caaacaactc tacataaaaa acttcaagag cttgaaatcg
       61 aaaaattagt cattgcaggc atgcaaactg aattttgttt agatactact tgtagaagag
      121 catatagctt aggttataaa gagaatattt tagtaaaaga tgcccatagc acatttgata
      181 cggctgtgct ttcagcttct aaaatagtag aacatcataa taatatgttg ggcggcaggt
      241 tcgttacatt aagagaagta aacgaaatta tattttaagc taataaagaa atacttagag
      301 acaaaaaaca gcctttcaaa ggctgttttt ttgttcctag aacgcacatt atattaatta
      361 agattgtggg gcgtatacag tctgaaaata gaaaaagacc atttcttccc agtcaaaact
      421 gagttaaccc attttatcga gaaatataaa gagcaataca caggagtaaa gaacaaactt
      481 tataaaattt atgtgttttg cgggatatac tagttattta ttcgatatat tcagattata
      541 aatctatcat tattcgttat cttatattta taggatctag gtggaatagc caagtggtta
      601 aggcaaaggt ctgcaaaacc ttgatctccg gttcaatccc ggattccacc tctaaattat
      661 aaatataagg agaagattat gaaaaaaacc tctatgacta ttattactac tctcttaatt
      721 tgcttttgtt ttactaatta tgggcatgct aaaacagaaa caaatcaata ttacacagtt
      781 atcttgaaag accgttctaa gtggacgcaa tctattaaga agattaaaaa gagccaggga
      841 gaaattactt ataccgtccc tgagatagga ctaattcaat ttaaaggaaa tcaaaaagtg
      901 gctaaaacaa atgcttcttt atttaaatct ttaagtcctt ctttaaaatt agaaaagcct
      961 tctacatcta catctaagtc ttttaaaaaa cctaattcaa gtgtaaactc aataaaaggt
     1021 ttagatagta ctcttcctgc cttatgggat atgcagtggg atatgaaaga aattacgcac
     1081 aatggagaaa gttataacat agaatcaggt tcttctaatg taactgttgg aattgttgac
     1141 tctggaattg acattgacca tccagacctc gtagacaatc tgaaaagtgg atcaaaaaat
     1201 cttgttccca aaggtgggct tagagggaca gagcctgaag aaacaggcga tattaatagt
     1261 attaacgata ttaatggaca tggaactatg gtagctggat ctattgctgc caatggtgaa
     1321 attaaagggg tagcaccgaa tacaggaatt aaagtatatc gtgtattcgg taataagtca
     1381 gctgatgctg tgtggatcat caaagcaatt attcaagcag ctaaagatga cgtggatgtc
     1441 attaatctta gccttggttc ttattatatt gatggtaaca tatataaaga tggtgaactt
     1501 ttagataata agtgggcaga tgttgaagga tataaacttg caattgagta tgctaataag
     1561 ttaggtagtg tggtagttgc ttctgcaggc aatgactcaa tagatgtttc caacaaatca
     1621 gagctgaatg attttcttaa gaaaaaatac gcggaagaag gaaaaacatt taacggagta
     1681 ggaattgaag ctccaggaga attgcctggt gtagtcacag tatcttctac tggtcctacg
     1741 caacaacttt ctttattctc taatttcgga aaaaattata ttgatatcgc tgctccaggg
     1801 ggagattcta gattgttaga gaaatacggc caagaggcat ggtgggatgg tggacttttc
     1861 cgacaagaac aagtattaac tacttttaac actggaagat atttatttgc ttctggaact
     1921 tcgatggctg cacccaaggt ttctgctacc ctcgccttaa ttatcgacca acgtcactac
     1981 aaaaaccgtc caagtaactc cattgattat ctatacaaaa acggagtaaa aaaagatatt
     2041 gaacctaatt tagcttattg gggaaatggt caactggatg tatacaacgc ggttaaataa
     2101 ataaaaaatg aactatgata ctcatagttc attttttatt tatttatgga agatatggtg
     2161 aattcaatac atgctccttg aggttcatta tttctggcat gaatttctcc accatgtttt
     2221 ataactaact cttttacaat atataacccc aacccatggt gaagttggtc attccttgaa
     2281 ggatctcctt gatagaattt actgaataaa aaaggtaaat ctttggtatc aaatcctttt
     2341 cccgtatcgg aaatagaaaa agacatcata tctttctcta tctgaacttg aacatcgata
     2401 ctcccattca ctggggtaaa acgaatgctg ttagaaatta agttagtcag aatttgatgc
     2461 aatcgttttg gatctaatgc aaattcggaa tttccctctc caggctttct attcaagctg
     2521 taagtgaact ttatttcttc atcctctgcc cattttttaa attcctctag catttccggt
     2581 aacatttcta taggaataac accttcaata tcaagtgtaa aatctggatt atctacctca
     2641 gacactcttt tcatttcctc tgtcaaatgc aatactcttt gggtattatt ttttattgtt
     2701 tgcaaatatt ggggcaaacg cttctgtcca tttaatgatg gatccattaa gacctctaca
     2761 tgggataata taattgttag aggcgttctt aaatcatggg caatcgaggc aaccatatct
     2821 cgacgctctt gctctaattt ccattgaaga taaagtgacg ttttcaactc ttctttcata
     2881 ctgttaaaag agtcaattaa tacacctatt tcattttcac tctcatattt aatctcaaaa
     2941 tccaaatctt gatttttaat tttctgagaa gcagcactca gttctttaat cggcttattt
     3001 aattctttcc caaaacgtct cgcaaatacg tatgagtaaa gtgttaaaaa taaaaaagga
     3061 attaataata ttataagaaa tatgtatttt atataatagt caatagatga tgctaacaca
     3121 tatcgtacag ctagaactcc ttccattcga tttttgtcga ggataggaag atatttcgtt
     3181 atgaccttcc ctttttgatc ggatctatta actttttcat atatactttt gttattttct
     3241 attaattggt catctaatgt accatatatt ttatttcctc gaaggtttat gacctgatat
     3301 gtaattcctt ccgtaggaat aactttttct aaatttttct gaaaagatac ttctaatatc
     3361 ttttctcctt ttaactcaac aaatttttct atgctaggaa cttttttctc gtaataatta
     3421 gcaggttgga ctgacttttc attataaacg gagagaaaat aatataataa aactaagctg
     3481 caaattgtac ttataaggct taaaaagatt actgaagcaa aggttaaaat aaactgattt
     3541 tttaaagata gccgtttaat cattaacgtt tttccaactt atatcctact ccccacaccg
     3601 ttttaatgtg ataagttgac atacctgaag tcaatttagc tcttaaatta ttaatgtgaa
     3661 ctataatagt atttaagtca cccattgcat caatacccca aattttctca tagatctgtt
     3721 ctttagaaaa tatttgtcct aagtttactg ttaaaagttc caatatctta aactctttac
     3781 ttgttaagtc tatcttttta ccatccaata aaacgtcatg ttgtgaataa ttaatagtta
     3841 aattacctaa gagacgttga ttctgagtac taactcgatc cctctgttca cgtcttaagt
     3901 gcgcctctac ccgagcaata agttctttca cttggaaagg cttcgttata taatcatctc
     3961 ctcctaaagt aaatcccttt actttatcca tctctgagtg cttcgcactt agaaacagaa
     4021 taggacaata aatttgttct ctgataactt tacaaagatc aaaaccatcc atctggggca
     4081 tcataacatc taatattatt aaatctacat ttgtctttaa ttgatctaat gcttgctccc
     4141 cattataagc tttaagaact ctataacctc ggtcttcaaa gatatcagag attatatcta
     4201 caatctccag ctcatcatcg actacaagaa tactttcttg cataagtata tacctccccg
     4261 cccccctagt attttaatta tctaggagag ataaattagt accctcctag acaaaatatc
     4321 atcttttcat agaacctttt tagagtaaaa gtaactagaa ataagataga taataaactg
     4381 agacactcca aatattaaaa atattactat tatagaataa attgtaattc cttctaatat
     4441 attttgcaag gcattagtag ctataaataa attcaatccc cctaacgata aaggaacaaa
     4501 gaatattacc gaaatttgaa tgtacaaagt ccttttaatt tctttagctg taagacccac
     4561 ttttcgtaat gagtggaata cttttttatc atcgttcata tcttcataca gtttaaacca
     4621 aagcagacta gctaaagcaa gaaacaaaac taagcatata aacagtcctg taagtctcaa
     4681 tattgaagat aattgaactg tattttcata atcgagaagt cgaatactat gaagattatc
     4741 cgatttgaac aaggttgtat ctgataattt ctttaaaatg ttataaattt ttgcatcctc
     4801 tttaaaatct aatttataga gtgacaatct tttttcagaa atcgttgttt tatatatttc
     4861 actaaaagtg tttttcggta cagagataat accctcaatt ccatctatag gattaagaac
     4921 tcttttaccg ttcatatttt ttacttttag atctctctcc cctttttcaa attttaattt
     4981 taagatttca ttagtaatat catcagtttt tttattatta aaaatataat tattattttt
     5041 taacgaatct tcatctttta taaaagatgg gtcattctgt attactaaaa attgcttctt
     5101 cccactctct gaagaaattt ttaatccttt ccacttattc atgtgtaaat cctttattcc
     5161 ttgtctcttc aattcagcta taatatcttc tattttgttt tccttcccct ttgatgcaac
     5221 aaataatgct ccttgagggt gagtgctttg cattctttga ctgttctttt ctatatataa
     5281 ctgaatagca ccgattgata tcataattgc agataataga atagatacga tgaagataat
     5341 ctttgcatta taatataatc tttttctcaa acttataaga gttaacatct ttatcccatt
     5401 caactgccgt ttttctttat tattcaaata agatattaca cctactaaac catttgaaca
     5461 gaataggtat gtgcctacta gtaataatgc taataggggt aaaaaagcaa ataatagcat
     5521 aggtaaagat gcataagaga taaatatata agaaaccaaa agaaagcaga tagacaaaat
     5581 gaatttaacc ctagagaatt gagctgaagg tttaggtttt ttttcttctt gaaataactc
     5641 tagaactgca attcgtttaa tcttgaaata actacgacat gaaacaagta aaaatactat
     5701 tccaaataaa ataaccgtaa caaaaacagc cacgggagag aaagtataaa cgaacgattg
     5761 atttgaaaat agaatatcac tcatgaaatt aaagaaaatc tttgataaca gcattccaaa
     5821 taaaatgcca actaaaatag aaaacgtacc aactacggcg ttctctaaaa cgagcacgtt
     5881 aaacaattgc tttctagagg ccccaaatgt tttccaaata cccatttctt tttttctttc
     5941 tctaaggaaa tgctcatgtg aatatgcgat aaaaaaacaa gaaaatagca aaataataat
     6001 ttcacatgca attaataact gttctgttcc cgaaaccttt ggatataaaa gaaaggctgc
     6061 gtacatataa aaaattgcta cagaaagaat gctactaagt atgtatactg tataatgaga
     6121 aagattacgg gttatattct tagttatata tttccacatt gatatcatta tcctccactt
     6181 ccttagcgat aaaagataag attctttgat tgaacttaga cgtatcttct aatttggaac
     6241 gcttcatttc atggacaatt tggccatcct ttaaaaatat gactctgtta caaaagctag
     6301 cagctaccga atcatgagtt accattaaaa tagttgtttt gtacttttca tttaacattt
     6361 ttaaagtatg tagaacattt tgagcagatt tagaatctaa attccctgta ggctcatcag
     6421 caaataataa agcaggattg ttaataagag cacgaatgat ggcagctctt tgctgttgcc
     6481 ccccagagac ttcataagga tatttagtta aaaattttgt cacttccaac tcttcagcaa
     6541 atttttgaag tttattctgt acacctttct tatctccttt ttttaaagca gcaggtaata
     6601 aaatattttc ttcaatagtc aaatgatcta acaagttgta attttgaaag atgaaaccaa
     6661 tatgctcacg tcggtaaata cctaattgtt cttctttcat acctgtgaga gtagttcccc
     6721 cgaccttgat atccccttct gaggggatat caagggaaga aagcacattt aataaggtag
     6781 actttccact tcccgaagga cccataattg ctacaaaatc gccttcttca atatctaaac
     6841 ttatattctt taagacaggg tacgttctgt acttagtttt ataaactttt gtaatttctc
     6901 gtgcttccaa tatagccatt ttaattcttc ctcctatctt tatttaagaa gtaaattctt
     6961 ttttactcca aatccttaca caagcaccaa aaccaactaa cataataaca aatgcaaaaa
     7021 catataaaga attgctagta gtactcagag tatgaaagat actttgaact gataataaga
     7081 aaaatgaaag ttggctggaa acatacaaac aacctacata taacccaatt aacaagaaga
     7141 agctaataac tgcatttgaa ataattacac taattaaact agcaagagct aaacagcaca
     7201 tctggatgat gaaaaagaga ccatacactt gtactgtata taatatagct tctatagcat
     7261 tcttctgttg accataaaaa gtaaaatcat tatctggttt taagaagata aaaccaaacg
     7321 ctatactaat ccctaggata attaataaat gtactagtac cattaaggca agagagaacc
     7381 attttgaaat tagaaatgat tttcttttaa aaggtctaat taaaaaaaga cgatatgctc
     7441 ctgagttata ttctacatta aggctattca gaaaaaatac tggcataaag atcaatgtaa
     7501 gtaagaatga agattctttt aataagaacc atggaaaatt ccaagtattt aaaggaactt
     7561 gctgatcgtt attgtaaatt ccaactccat agtatcttaa gaaccaagct tgaagaagta
     7621 caattacagt aaaaatccca atcatccatt tactttttct ttggctccaa agtctctccc
     7681 attcgcttat aaataatgct ttcaattaaa accctccttg agtcaaataa aataatctct
     7741 cttcacaaat gtccaataac caattaagcc aaatagagca atgtatacgg cttgaactaa
     7801 aatgatgtaa gaatttagat tgttagttga tgaaagtaaa aacgctattc ctgtgtgctg
     7861 aattttcacg atagacatgt acataaggtg aaccactgtg ctgtgcccga taattgtttg
     7921 cgtcgagaat tctaagagct gaggaatggc aattgctaag aaaataaagc caacccctgc
     7981 cccaagtgtt atcattgtac ttctgcttat cgatcctaat aatgtaaaaa ctgatacaac
     8041 gctaatcatt gtcacaaaac aagcaaagaa atattttacg ttatataata aagctgctgc
     8101 taaagataat ttctgctcat ctagaaatgt tattaaggta ttaaccttag gaaaaaagat
     8161 ataaccagca acggtattta aaatccaaaa tagagttaaa tacaagaaca tggttgttaa
     8221 aatagtagct aattttgcta aaaaaagttg agtggtagaa aaagggcgga tgaggatcat
     8281 tcttagctgc ccattttcta tctcattagc tataaccgta gaaattagta ttatagctat
     8341 gatattaaaa gaaacaacga gatgttcaga aatgctaatt atagggaagt tcaaagaagt
     8401 tacataatct ggttgtcctg gtgacactcg ttcattccaa tttaagtaat atttaactga
     8461 acctagcgac attaagggta taaaaaatag tatgatccat gatatctttt gggaccataa
     8521 tcgttctaac tctgaagtga aaagtccttt catgatgtca tcatctccac aaatacatct
     8581 tccagtctct tgcttggatc tttaattaac tcttctttac ttccttgtgt aacaagttta
     8641 ccgttacgaa taatgacaag atgatcacac atttgttgga tttcatcaag taaatgacta
     8701 gaaatgaaaa atgttagatt tttcttttct cgaagttcaa gaattaattc tcttaattct
     8761 ctcattccca tagggtcaag accatttgct ggctcatcta ataaaatgac atctggttct
     8821 cctaagaggg cttgagcaat tcccagcctt tgtcgcatac ctaatgaata attcttaatt
     8881 tttacatcgg catcttccgt tagtcttaca acagataatg ctgcctccac ttgctctaac
     8941 tgttcttttc tcgaaaggtc gggatatagc ctcgctaaat tttgtaacat ctttctgcct
     9001 gacatatacg ggaaaaagat aggggactct ataatcgctc ctacatttct taaagcctgt
     9061 tgtctatctt tatttacatc tttaccccct accattattg tgccttgagt agggcgaata
     9121 agccctgtaa acattcgcat aacagttgtt tttccagctc catttggtcc caaaaacccg
     9181 catatatctc ctttatacac cttagttgag aattgactta caatattctt tccactcact
     9241 gtttttgtga tattatttgc ttctaaaaca atttcttttt tcatattcaa tccctcctta
     9301 tggtttaata taaaagacaa atataaataa aaaataaaga aaagaaaaaa actcacattt
     9361 ttgtgagttt ttattgaact tcaacttttt cacaaatatt cgctagtcta tttctttctt
     9421 ctaattgttt agaaatgatg ttcaatatat tttgcggatt aggtaaaaca tagttaggtc
     9481 tcaatgacat agttgcaatt tcaaaagctg ttgtttttac aggaggtaca acaatatgat
     9541 catattgttg tagtagctta acattatgct gaactacttt cttttcccac attaatttat
     9601 tcatgtttgg aaaaaagata acaggtttat catgagctag tattactgta cttaataaat
     9661 cagttgctag accatgagct gctttagata atgtgtttcc tgtagctgga agtacggcca
     9721 ttaaatcgga ccacctcgct aattccacat gtcctatggt tccacttatg ctaagctttt
     9781 catcaataaa tacctcgtca caatataact ttactgtctc agctgggata agttgaactg
     9841 cacctttcgt cattacaact tttacctcac taaagtttgc ctttagcata gctaaatatt
     9901 gaaaaatgcc tgctactgca atcgacccac ttacccctac tagtattttt ttctctacaa
     9961 tattcttaac gtccatttat catagccccc tgaatcttaa ttaagaaagt aaaaatgccc
    10021 cgtcccacca aggttcttcc actgaactta aacttagtaa aggtaataat acgccagtta
    10081 caccttcgag taatccagcc ttgtttaatt gatgtgactt ctctccattg gattctatat
    10141 ctctaaaacc aaagggtgca ttagcatcat atgattcttc tatataatgt actaactcta
    10201 ctattgattg aactgagatt tgattctctt catcttttgc catccttata agcatttgta
    10261 ataatcctgc tcttccatga caaaatgttg gcgatactaa ttcccattct tcttttggtt
    10321 ctactattat gtcctgataa gctcccactg cactccttat tgctgctgtg tcgcccaagg
    10381 cctttcctgc taaatatata cttctcgcta cgcctgggtc tccataacac cagccctgac
    10441 gttttggata agaatgagat attttagaag tggctacttc ttgaaaacta agtctggaag
    10501 gccaaccact gtctacttgt ttccacttca ttaaccaatt ggtaatcttg agtacagctt
    10561 ccctctgacc aggtatttca attccctttt gaatcgataa ggccataaaa gacagtggac
    10621 ccggtatgcc atgagcaaga ccacaattaa aattcccttc tggaaacata attctatctt
    10681 tttctagtag ttgattcgct tttgaaacat accaccccgg tactttttca ccatttacct
    10741 cgatatcaga agccatatcc acaaaataag taagtatttt ttttagtgcc tcatgatttt
    10801 ctttatgctt cgtattttca atgagatagc gacctattcc tgtcattcct tgtatcacat
    10861 catattttag aggatgtaca cctagttcct tctctggttc atttaatatc ttttctaatt
    10921 gcatcaatat aaaattattt aagacttgga ggaatctaga atacctctca taattatggg
    10981 atatatataa cgtggcataa gcgacacctg ttatacctcc aaacatcgaa atactattga
    11041 ccccttgcct ttcaataacc ttctgtactt ctactaaatg gttatgtgcg acaaggtcaa
    11101 acccactatc agggaactga cggtcaagtt ctccaaataa taaaatagtg cctggaaaac
    11161 catgggacaa tgtgataggg tcccatggat tcaaattacc tgccaatgat acgttatcag
    11221 gagccattac tatcttttct ataccacttg gatcctttaa cttttcagct atgcttaaca
    11281 ctaattttag tgctttattt cttgtctcat tatcaattcc ctttaaccaa tacgtttttt
    11341 ggtcagtagt agatggcata attttctcct ttctccttac atcttatgag cttgcttgtg
    11401 ttgcactagc ttctatataa ctcttagctt gcagattaaa taatctggcg tatattccat
    11461 ttgtgtctaa aagttctaca tgagtcccat actccgcgac ctctccttta tcaagtacta
    11521 taatcctgtc agcgtatttt acggttgagt agcgatgaga tatgaaaagt cccatacttt
    11581 tctgagcaat ctcttgaaaa tcttgaaaaa cttcttcttc ggctgctgga tctaaagcag
    11641 cagtcggttc gtcaagaata tataaacttg ctcttctcat ataggctcgc gcaatagcaa
    11701 ttctttgcca ttggcctcca gataattgaa taccgttagc aaaagttttt ccgagctgag
    11761 tatccatttt atcaggcaag ctatcaatca ttgtaagcgc tccggacctc ttagctgctg
    11821 cttgtatagc tactaaatga ttagaccttt tgtaatcacc ataaccaatg ttttctttga
    11881 catctaactc atatctcaca aaatcttgga aaatagcact aattctatcc tgccaatctt
    11941 gcggctgata gtcctcgatt cttttaccat tcaagagaat aatcccctca taatctgtat
    12001 atagtcgtgt tagcagctta acaattgttg attttccaga tccattagat cctactaaag
    12061 ccaaagtctc tccaggttta atatgaaaat taacattttt taatgtgtaa ttctcttgcc
    12121 ctggatattt aaaggataca tttaaaaatt gaataccttc ttccgttgaa gagacatttt
    12181 ctaacgtttt ttcctctgag acattaggtt tatctgtgct ttctggaaca ttaaggaagg
    12241 aaaataattg tgtcatatat agattgtttt gatgcatgtt aaaaaccata tacattaact
    12301 catttgacgt tttttgagtc gtgttgacag cttgaaaata agcaataagg ctaccaatag
    12361 caattaatcc ctggattgta tctttaacaa tcataaattg aacgaatatt acaaaaatta
    12421 cacttatcaa ttgaaaagat aaatcaattc tcatcttttt taaaagcaaa tggcgatcct
    12481 gattatagaa cttactaaat aagtctgaat agtttcttag tagtaagctg cctaacccaa
    12541 atattttaac ttctttaacg gtaatatcag tggtcattag atagtagtaa taaaactgtt
    12601 ttcttgtctc ctctgctcgc ttatggctta ctaaaaatat ttcttttccc acattcacaa
    12661 tagaccaggc ggatattaaa ggtaataaaa ttaagatcaa tgtaaattcc cagttccaaa
    12721 ccattaaaat tattgaaata gaaattaaag taatagcacc ttttacgatc cccattaact
    12781 cttcaaaaat agcaaacggc ttatacgtgg aatcttgcct tgctcgttgg agtttattgt
    12841 atacctctgg gttttcaaag cttgcataag gtagtctttt cgctttttca atcaatttta
    12901 catttatctt gttagacagt aggtttctgt atagttgctt atgcgtttct aggattgaac
    12961 cggtagcgct ggttaataaa gtgacaactg aaaagaagat aaaaaaaggt aaaatgtcgt
    13021 aaaaatagtt atctttgtac ccttggatat acagattctg caccatattt acaagatatt
    13081 ttattgctaa aatcaaggaa gctggtaata gcccatttag aaaatttagg acaagaacac
    13141 agaagaaata tcctctgtgt gtctcccaca aaagcttaaa tagactcggc cagtatcgaa
    13201 aagattttag aatgctaaca aatgatactt tctcattttc cattgtagga tctagcgtat
    13261 tcttcattct tattcctcca atacttctgg ctggacaaaa tatgtctagt aaaagctaat
    13321 gctttcttct ctaattctct atttgctcct aataatcgat tacagtacat atgaataatt
    13381 gctcccataa tcatttgatg ctcattccaa agcatatctc ttttctgtaa ctctttaatt
    13441 tcagtcacat aacgggttaa agattcttta cgaatcaaga aactttcata tatagactta
    13501 ccgactccag aattataatt acgcaagttt tcccaatcat ttcgtgaatc tcctattaga
    13561 gataattctt ttcgcaacgg tctaaattca tctatatact catatttttc tgtattattt
    13621 tctatagagg ctacttgttg cgcgtaattc aacccaaagt tatccatgat gtctataatt
    13681 gagagcgatg ccattacata agctgaaaga tgattttgtt gatttaacgt actgagaatc
    13741 atggctacag actgactatc gtaatgaaaa taatcctcag ctttttctat taacatggga
    13801 ccaccataac gctctacttc tcgttcatat gtgtcgatag taatcttttg gagtaatcct
    13861 aaatccatta gtttatctgc ccattccctt aaacgaggaa gaactagacc actaagttta
    13921 gaagggtctc cctgaaagcg taaacgaata tgtgcatcag ggtctcggta acgcataaag
    13981 aaccatgatg atgccatatc acttttaacc atttcactag cgaaaggcgt aagatatttt
    14041 agtattaagt cattctctct tgcgtttgga gcatagagtt ttacatataa ccactcgctc
    14101 cctggtaatt tgtagattat tttattactt acaatatctt ttttcgcttc ccctattgca
    14161 ccaattttct ttcttcgctc agtattttct gttttcttta aaggaacaac tatttctaca
    14221 gcatgtctcc ctaaagggct atttaagcaa ttttgatccc gatcttgaag agtttctctt
    14281 aattgcaacc ttccttgctt gaataattca ttttttagtt cacgtaggtg taaagtgttc
    14341 tccaagtcaa ttaagatgcg attgtctcca taagtcataa atacattacg aggaactgac
    14401 cacttttcgc gccattctcc aaaagcttta aaaaattctt cctcattctg aggcttctct
    14461 ctcataccga aaacctcttt attcaatttc caaatactag gtgaaataac aatgttttta
    14521 tagcgaattc ttggatagta aggagagtgt gccatacttc cccaattaaa tggtcgccat
    14581 tggtctaaat cattgagtga aatctccctc ataaaacgat aaatattagg cgcactttga
    14641 taattaagca tgttaccggc tactacttta attcgtttgc ctagtttttt tgacttcata
    14701 tagaagttct ctaacgatgc tcctaccaca atatcatcga taggtaactg gattgtctct
    14761 tcatcaccgt ttgttcccag agtgacgttc acttttcttg tcgtttttcc aattgctacg
    14821 ttggctgatc ggccagttgc tggcagaaag gagccttcta ccatcacggt atcttcgttg
    14881 aattcaaggt caattttttg ttgatactgt tgtattttta acgaaacatc cggatctaag
    14941 atatctaaaa atcgaccaaa tgtgctacct aaggcattag atccagggtt aggacttaaa
    15001 cagaatgtat agttaccttg atctaagtcc tcttgtgaag cagcatgtaa ctctccatat
    15061 acttctaaag agtcaggcgc atatcttcta tctttttctt tactcattct ctgagctatt
    15121 tcttctgtaa tctcgatttc tttttcttga ttatgaatag ctttaataag aagatatgat
    15181 aactgactat tacgttcttg atttatagaa gaggtggtag tatctcctcc ccttttccca
    15241 tgtggatttt gataagaggc aggtgcaccg agacctaact cttcacttaa taattctagt
    15301 aaaggaactt ctctagatgt tccgtatttt tctaaaaaat caacatgata cttttgtaaa
    15361 tgtggaaatc ccactccctc atcagctatc gaccataata tttgggcagc tttgcttatg
    15421 tcttctccta ccttttctcc aatagttaag tctgtggcat ttaaggaaaa atctacttga
    15481 aggggagttg taacttcata aatatgtcgc atttgtgaaa tcaaatcact ataaagggag
    15541 agaccttctc ctaatggtaa ttgattataa gtattgatta gttcccttac ctttaacagt
    15601 tcctcataga gctctatctt ctcatctttt tcttctaatt ttctaatgag ataattaaat
    15661 ggattatcaa tagttaaagg aggccttagt tccgttataa gatattcttg ttccaatagc
    15721 tgtataataa agcgttggat tattgtcaca tctgtatttg gataaatagt atgtaacctt
    15781 tgtgtaattt ctctcactgt tattctttcc tcagctaaat taagaacctt ttcaaccact
    15841 tcgctataaa ttatggaaat attttctctt ttctccatcc ccttttttct aagttgacca
    15901 cattcagttg aaaatggcaa atgaagacga tcgcctacta catacgatgc acgattctta
    15961 tctacaatta gagaaggaag gatattgctt ctttctaaaa ctgaaataac tcccaaaagc
    16021 cactccatat ctggtcgtgc cctcttctta aactctttga aatgatctat tttcagggaa
    16081 gaattctttt taaattgtcc agctgctact cctgaaaaag ctccaaaagg agttggtcta
    16141 gttgtcattc ttaacatgta acgcaacata gaagataaaa cttgttgggt ttttctatta
    16201 tttaaatcac catgtatgta atgaagggaa tttaatagag aaggacttgc aatagcaatg
    16261 gcttctttta cataatcttt ttctgcataa gctcttaact tttccactaa tactgcttcg
    16321 tctttaagtt ggtcgaaggt atgggttggt aaaaacgggg ctcttaacat aaaaaatgga
    16381 agaggttcaa ataaattatt ttcagtagtt acgctagatt tataattgaa tttttctttt
    16441 tgtaatatca attttaatct ccctttcctt ttataatata attcaaaaga agagaaaaga
    16501 gggaacaaca ttgtttccct ctttttcaac ttctaattag cagcagaagc tgttccaact
    16561 acctgtatct ccacaacctg gtgtacataa agatacactt gtaatttgtg gatctacatc
    16621 acttgaagca gttgttactt gtacatctaa atcaaaaagg ttttttacgt tattcatttt
    16681 tcattccccc agaaagtttt tattaagacg ctatgtctta tacatttaat ttaccagacg
    16741 cttttttata aagaatccgt atataccgca ataagatttt gtaaatttcc gcatatgcaa
    16801 aaaaatacat aaaagtatag tattgaaaaa taaatagttc taatgtacat ttttacttat
    16861 agtagtttaa taaccatttt ctagaaagag ggtttttctt atgactaaaa cactatggaa
    16921 ttttttaatg gagatgaaaa aaaataatct tacctttgaa aattatgagt tatgtccatc
    16981 tttgaatgcc ctgtcacctg aagaaaaagt tgtattaaat gaatatgcaa gaagtttagt
    17041 tttagaaaac gaggttggaa atgaatgggt ttagaagcga tttaattgat catattaacc
    17101 agcatctttc tagctataag caaagtggaa gagcagaagt agaccttctt gctctaaagc
    17161 acctctctaa aagaggaaaa ttattaaacc aagaactttc aggattctca tggggagaac
    17221 tataccttac tctctcttat tttttaaaaa gaagaaaaat gacagaagaa gattttgaaa
    17281 aagcttttgg tattgaatgt atattcttat ctgccgacat agtagatgat atatgtgatc
    17341 ttgatgatcc gaatcttcca acctttcaaa atgaagatcg atatcttata ctcatttctc
    17401 aatatctact ggcaaaaggc ttcttctatc tcagacctgt atcagactct tatgaagaca
    17461 attgcctctt tagcctcata atggattcag gatgtggaga atggaaagac ctccactttc
    17521 gtttctctat aaataaaaga gttataccta ctgaagagga gtattttaaa ctgattaaac
    17581 aaaaatccgg taaattaaca gagataattt ctcaagctat cgatccttca caacttatat
    17641 taaaaaaaat cacttattat ataggcatag ctggacaatt gagaaatgat gctgcagacg
    17701 tgctaaatga caaaaaaagt gatcttcgag atttaaaagc gtatctgcct tttttaaaag
    17761 cttatgagta cagttgtgaa gtacaagatg aattctttca taagttaaaa gatgaagaaa
    17821 tcatgacctc tcctttaaaa agacagttga taagagaata catagaacaa tctggctcta
    17881 tcgattattg tcatatctta tccaggtttt actatatgag ggcatttaag cttttagagg
    17941 aacattttaa gctttcaaag aaagaaatga actacttcaa atctttattt ctacaaagga
    18001 gtcaacagca tgaacaagca taatttatta atttgtttgc ctttaggcac tttgtacatc
    18061 atcattttta tggcgaatgg ttattattta tatctaagcg attttagaag atttgtggat
    18121 tcggcaactt taaattcttt ttatgtaaca agtgttatta gtttgatatt ttttagcatc
    18181 ggattattta gcttttttaa gaaacaaaag tccatcgtga taaaaaattt cttcttacta
    18241 acatctgtct ctggtattgc tatttctact tctgttttgt ccagtcagga tataccagtt
    18301 tttaaaacta tagagatcat tagtgtattt atgctctctt acctattact aagtttcttc
    18361 gcccacttcc cagtttcgac taaacctaat tatgtgaaaa ttataatttt ttcatcatta
    18421 cttttctcaa ccctgtcatc tgtagtgtac ttaatttgca attaccttgg ttatgtagag
    18481 cattctaaat ttttttacat atacagagtt ttattaatcg gtaacttgtt ctttagtatt
    18541 gtgggctgta tttttcttat ctctttacat ctaaaaacta attcattaaa agtaagaaat
    18601 cagttatata tcttgatctt tggaattgtt tttagctttg gtccactttt tttattcaat
    18661 ttaatacctg gaatgatttt tggagaatct caaatacctt ttgtctattg tttacccagc
    18721 attatagtct tcccactgac aacttcttac ttattagtaa agcatgaaat tattgaagtt
    18781 gaattggaaa tttctaagtg gattaatata ttgatttatt acatacttaa ctttttgctt
    18841 tttagtattt taattaaaca atttatgcac ctttctaata gagaattatt tgtcatatgt
    18901 agcgttggcc ttttatctgc atgggcatct attttccttt ataaaatagg tattaacact
    18961 tttatacaaa agaagacaaa aaatagagag aacacggacc tgaatgaaat tgaacttttc
    19021 caaacattgt ctaaagaaaa acatgctaaa aatcttgcaa aaattatagg aaaagtcatt
    19081 catcagaagt tcgatatcaa tggtttatgc attgtgtgga attctaataa tatatatcat
    19141 tcattacatg agacgggcat ttttcaaacc atgaatcaat ttaactttct taatgaaata
    19201 aacaaacttg aaaaagatat acttcttgtt gaagatcaaa cccctagcat acatatgcat
    19261 tttgaaaaat atcacttaat ctgttttcca atcgcaataa accaattagt tcaaggtgtt
    19321 attgttatag gtgaaaaaaa caaccatact ctcttccaag ggaaagagtt cattgagctt
    19381 aaagaactaa tatgtgaatc agcagatata ctttcaagtg cagctattct caatattaat
    19441 gacaaacaaa tacgtcgaac aaagacaaga gttcagaact ggaaccaatt taatcaccaa
    19501 gtcattcagt ctctagaaaa agagaggaaa agattgtcca ttttcttaca cgatgaaatc
    19561 cttcaaagtc ttattttgca attgaatgaa gttagaataa tgcaaacaaa aaggaatttc
    19621 tcagtaacat tactagacga aatggatgat cagcttgaag gaatgattta taacattcga
    19681 aagatgtgtc atgacctcca ccctatcatc gtggaggatt tgggtctaga gccaagttta
    19741 cagtctttaa aacgagaatt tgaactaaat tatagtatct taattcatgt tcaatttaat
    19801 tgtgagttca aaatcatttc taaaaatcat gaaatacaag tttatcgaat aataaaagag
    19861 ctgttaaata atgctgttaa acattcaaaa ggtaaaaaca ttaaggttct tattttagaa
    19921 gagaatggtt tctaccagtg cagcgtaaaa gatgatggca taggatttga tgtcccagac
    19981 aatttctttg attttagtaa aggtaaccac cttggtttac taactattca tcgtcaaatt
    20041 gctgaattaa atgggagtat gagaatttct tctgataaag gacaaggtac ttttgttaca
    20101 tttactattc cattggactg ggaggataaa aatgagtata cgtacgctac tagtggatga
    20161 tcatttactc gtaatgttag gaatcagaag attactcgaa agcgaagaag acattgagat
    20221 tatagataca gtcagtgatc cctcgtcttt aatagaagtt gtagcaacta catcccctga
    20281 tgtagtcgtt acagatgttc gtatgaaaga atttaacgga attgagttaa caaaagaact
    20341 tttgtctaaa tttccagaaa taaaagttgt cattttatca ggctatgatc acgaggaata
    20401 ctacaatgca gcatttaaag caggagctag tgcgtatatt acaaaagaaa gatctgcttt
    20461 cgatttagca aatgctatcc gtcaaagtaa tatgggctat atactattct ctaaaaacca
    20521 gattagcacg aaggactttg aaacccttac ttctgcggag caaaagatac ttcttttaat
    20581 ttccaaagat aagacgaatt atgaaattag tatggatctt tcaattagta aaagaacagt
    20641 agaatatcat atttcttcta ttattagaaa gttagatgta gattcacgag taggagcagt
    20701 agtaaaaggc attaaaaaag ggttgattga agatttttaa aatttagaaa tagataaaat
    20761 agcagaaaaa gatatataaa taaattcaaa actagatatt tctatatcgt aagtgtgcac
    20821 gatgaaagat ttatcagatg gaatacagtt aaaggtgagc ttaatgaaga tatagtagat
    20881 gacaattgcc ttgcctaact aaaagaagaa gataaataat tcattagaaa aatagaaaaa
    20941 atccctggtg cgttaggggg agcttttctg ttacacatat cttatttaaa gaacaaactc
    21001 ctcaagtcat cttgaggagt tttttccaat taataataat ttatttattg atgccacctc
    21061 ttgtctacat acttcttgaa aatttagatt tagttatttt ttaactcttg ttacactaaa
    21121 aagtttttct ccataattaa ctttactaat accaactctt gcaagtccac ccacaatagc
    21181 aggaaggatc catcctgacc ctatttcata cataggaaaa tatagaagga aataacttat
    21241 taaaatgtgt agaacatgca cttataagtc ctacactgtt tgttttattt aataatgaca
    21301 aacggtgtct tttacttctt atggtataca gacctatcct ctacttacct tttaagaaat
    21361 tgttttatta aagacaacca aacataagat ttataaacat tcaatgttat tatcttttta
    21421 aaaatatata cttaactgaa aatataaaat aaatgtattc tatacaaaaa agtaaatata
    21481 taaacttctt tataaaaaat aaagttttac tatttactct acctgacgac aaatacgcac
    21541 tttttctaca agatgagtag tagttaaact attattaact aaagtattat attatttact
    21601 ctcataaata atataacgac atatattatc tatattctaa aagtaaaaag tattaacaat
    21661 ttatttaacg aagtatttta aaattaccta acgtctatta tttttatttt gatgttcgtt
    21721 ttgataggga tgctttcctt aaggtataca agtagaattt atctttaact attttactca
    21781 ataattcctt tacaatttaa ttttctaaat atttgaggca agttaactaa aaaaggttaa
    21841 attatccata tctctcttat atactaaaaa tgaaccaata cacaataaga aggaggaaga
    21901 aatcctatga taagcataaa aaaagctgtt tgtactcatt atggaataag aatggacgtt
    21961 tttaaacctg aggaaataat tagcttcaac catatgcact ccagaggata ttttacttgt
    22021 ccttattgtg gcgatatcga aatcactcat gaatgccaag aaggaaaatc aaggtttgtg
    22081 gttgctgcta atagagatca tactcatgat tgcctctata aagagtcata aaaaatcctt
    22141 ttcaaaatga catattttat agaagaaact cgtcaaaaaa gtagcctttg ttcaacggga
    22201 gcagaggctt tttttaattc aggcaattgg gaaatacttt attagtttag gctaaattta
    22261 aaatctacat acatattttt aaaacaatat agggttgaat tttactccat gattcataat
    22321 caaacttcaa cggatttcat ttcgtcatag agtaaatctc agtataattc ccccctgaaa
    22381 aataggagtt cctcttccat tttccaacct tattaagtga caagtgtgta gaagctatga
    22441 tatgttagca tctctacata ttatctaaaa ataagaagat gaggtgtttg aatatgaata
    22501 aaactgaact agtagatgca gttgcaacaa aatcagaact aacgaaacag gattcaaaaa
    22561 aggctgtaga tgcgttgttt gaaacgattt ctaatacgct tgccaaagaa gaaaaaattc
    22621 aattgattgg atttggtaca tttgaaatac gtgagcgcgc agagcgtaca ggtcgtaacc
    22681 ctcaaactgg ggaagaaatg acaattccag cttcaaaggc tcctgctttt aaaccaggaa
    22741 aagaattaaa agatgccttt aaataaatat gccttataat caagtcccct ctagagatag
    22801 acttctaaag ggggctattt tttatagtga aaaacttcta aatacctaca cctacatatt
    22861 atctaatcaa ggtttctatt ttcttgcgtc gtcgtcttag agttggagtt aggctctttg
    22921 ccaagtctag gtttccaatt tcctaacttg tttcttaagt aatcctttaa aaaatcacgt
    22981 ttcttttttc gtcttttatt cctgtttttc ataaggactc accaccttta gattacttaa
    23041 tagatgcaat ttcttcttat tattataatt atgttgaaaa atccattctt tatgctaaat
    23101 ctataagtaa taagtagttc atcttactag ttaaaggaat acttttaggt atagtttcaa
    23161 agtattccag aagacgtatt ccattgtaag agtatcaaaa gtagaacatg aggaacaatc
    23221 agatgatcct catatgtact gtcataatca ataataaaga aagcaggtta atatttatta
    23281 acctgctttt cagactaaca agaacttaaa gatttctcgt tagaaaggca tttatgattt
    23341 cgtagaagaa gcatcctctt tctcagaggt aaaaacttta tctttgaagc tagatagatg
    23401 ttttccatgc acatcattga catttgcttc atcagaagta tagccagcag tgttaaatct
    23461 gtcatcccct attgcaggct tagaattgtt agactgattt ttcattgtgt acctcctagt
    23521 ttgggttgga tagacttagt atgctcatgt gcatggtatt ttatgaggat gcgtttaagt
    23581 taaaaggtat tggaaattta accaatctaa agattaaaat gttccattaa aataatttct
    23641 catagtccta ttttcaaaaa attattatat gtttttttcc tttttttctt tactcgaaat
    23701 gcttttgaac ttaaatgtaa ttagttatag attagaaatg tatcgctcaa aaatacgtat
    23761 acttttccct atttgtaaaa gtatagattc acaaataaaa ggctccttat catagaagaa
    23821 atagagcctt ttaccatgtt gtttccgaca ataatggtta tgtaaactag ggctgtatat
    23881 gacatacaac cctagttaca gattacttat gttgttgata ttttattaat ttaacccctt
    23941 tatctgtatc accttcatct aaataatccg ttaaaacttc aaattgaata atatcagtac
    24001 cttcagttac ttgttttccc ttttcttcaa tgactgggga taaactaaaa gtgacaacat
    24061 atttaatatt tctcatgctt ctttcctctg tattttcttt aatgaattgt tgaattttta
    24121 taaaattctc tgaagttctt ttatacccta caaggctttt tccataatgt tcattcatag
    24181 actcagttaa cttttcactg agtaaggaga tcataaaatt atcataagtc tctttagtat
    24241 ttaaaggaga ctcttcatat ccttgttcag cattagcaac aatttggctg ttgaacgtca
    24301 aaaatataat gagaaacgtt agaaatagta attttttcaa ctgagcacac ccttttttat
    24361 ttttagagtg tgttattttt tgtgaattat cctttgctgc cgagaacatg aattatggta
    24421 actaagaata aaaaaggtat acacatgaaa cagaaaaaac ggctgaatct tagctgtttt
    24481 ttcgtttgag aaaaattata ttatgactca ggtttttgat atttttttaa taattgaata
    24541 ggaccttgag tgtttatttg gatcatttgt tgagccatag aagaggggga ttctaacata
    24601 tcattttcta accaccaaga aataacaccg atataagcag cagaaatata gctaactacc
    24661 atctctttag caacaggaag ttcattctcc actaaattag cttctgaaat tgcatgatcg
    24721 taaaattcaa acaaaaattc ttttaaataa tgtataaagt taggaatccc ttttcctata
    24781 agcataactt gaaaaaattt cttatgtcga gcgatatgtt caaaaatatg tgaagctaca
    24841 tatttttgca attcatcaac atttttactt acactgtaaa atttcgatgc ctccccaaac
    24901 agctctttga gcatcttatc tatgctttgg tttagtaact cgtctttgtc tagaaaatga
    24961 cgataaaagg ttgcacgatt gactgttgca cgtgtggtaa tatcttgtat cgtaattttt
    25021 tcatacgttt tctcatctat taactcaatc aaagcatctc gcagaagatt ctgagtacgt
    25081 tgtactcgag ggtccacttt tttgtttatc ataataaacc tccataaatt aattttgtat
    25141 ttttgcaaca gtattttagc gaggtgttgc ttaagcaaca ttacactgtt tattgattct
    25201 tgttattata aacgcccttg ttataattat ttaatacaaa tgttgttttg gcaacaaaat
    25261 tctcaaaagt aattaatcat tatttactta gagagttaaa caacatgatg ttttaataaa
    25321 atttcttgat tactggttat ttaagtggaa ataaaccagc atatccacgg aaatagcaaa
    25381 tcaagcttta atttaacaag gaaggtgagc atacatgcaa caagacgaag taataaaaca
    25441 gtttactaca ccattaggtg ctccagcatt tccagtaggt ccttatcgat ttcataatcg
    25501 agaatatcta aatattttat atcgcacaga tatagatagt ttacgaaaaa tagtacctga
    25561 acctttagag attacggatc cactcgttcg ttttgagatt atgaagatgc ctgatgtaac
    25621 tggattgggt tcttatacag agtgtgggca agtaattcct gtaagcttta acggtgagga
    25681 aggtgaatat ctgcatgcta tgtatgtaga tagccatcct gctatcgctt ctggaagaga
    25741 gataggtgct tatcctaaaa agttaggtaa acctagttta tttgtggatt ccgatacatt
    25801 agtaggtact ctcgactatg gttctttgag agtggcaact gcgacgatgg gttataaaca
    25861 ctgtcctctc gatttatccg aggctcgtaa agaaatttgc aagcctagct atatgatcaa
    25921 aaagatgccg gggtatgatg gatacccaag aatttgtgaa cttgttcgta gtcaaataac
    25981 agatatcacc attcatggag cttggtcagg acctgcacgc ttagagttgt ttgcacatgc
    26041 ccttgcacca atgtcagatt tacctgtgta cgaggttgtg tctacctctc acattcttac
    26101 agatcttact ttggcttctc cgcgtgttgt acacgactat ctggcaagca agtaatcaca
    26161 ttatagagaa ggcaaaccta attagaaagg aaagaaatga gtatgaatat aaaaactaac
    26221 agtcctcagt tacctgagaa tctacgtaga ttcaaccctg ttacagttat tggcgctggt
    26281 gttattggga tttcatggac agcttatttt cttgcaaaag gcttagaggt tcgagtaaat
    26341 gatgtgcgtc ctgatctaga agaagttgtg catacgggga tcgaacagat tatcccaaca
    26401 ttacgtgaac ttgggcttcc aactgaaggc cttacagatc gattagttat t
//
