GCF_018986755.2 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP075604.2 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-ii	423,332	446,313	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide
Region 1.2	terpene-precursor	985,209	1,006,090
Region 1.3	RiPP-like	1,478,482	1,489,363

NZ_CP075608.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	RiPP-like	9,687	20,061

No secondary metabolite regions were found in these records:: NZ_CP075605.1 (Enterococcus faecalis); NZ_CP075606.1 (Enterococcus faecalis); NZ_CP075607.1 (Enterococcus faecalis); NZ_CP075609.1 (Enterococcus faecalis); NZ_CP075610.1 (Enterococcus faecalis)

Compact view

NZ_CP075604.2 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 423,332 - 446,313 nt. (total: 22,982 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

KKP64_RS02170: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

KKP64_RS02160: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.97	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001407.5	0.48	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.97	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001407.5	0.48	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KKP64_RS02160

KKP64_RS02150

Leader:

MENLSVVPSFEELSVEEMEAIQGS

Core:

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

Core with dehydrations:

GDVQAEDhbDhbPVCysAVAADhbAAADhaDhaAACysGWVGGGIFDhbGVDhbVVVDhaLKHCys

antiSMASH-DB 4.0 matches for KKP64_RS02150

100.0%

NZ_AP026721.1and 34 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide

Lanthipeptides: PO855_RS02210_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

93.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide

Lanthipeptides: BEH_RS02105_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVVSLK C

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVSLKSC

90.9%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide

Lanthipeptides: BEH_RS02110_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVV+LK C

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVTLKSC

with 107 more sequence matches

Only the first 10 are displayed here.

86.4%

NZ_JH791802.1and 5 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptideNZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide

Lanthipeptides: IKS_RS30065_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AAT AASSAACGWVGGGI TGVTVV++LK C

GDVQAETTPVCAIAATTAASSAACGWVGGGIATGVTVVITLKSC

84.1%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26130_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA+AATAAASS C GGGI TGVTVVVSLKHC

GDVQAETTPVCAIAATAAASSGICAATGGGIATGVTVVVSLKHC

81.8%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide

Lanthipeptides: COK11_RS25880_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCAVAATAAASS C G GI TGVTVVVSLK C

GDVQAETTPVCAVAATAAASSGVCAATGAGIATGVTVVVSLKSC

77.3%

NZ_MIFM01000001.1and 1 other:

NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide

Lanthipeptides: BHL22_RS00425_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCAV+ SSAACGWV GGI TGVTVVV+LK C

GDVQAETTPVCAVSVATMTSSAACGWVAGGIATGVTVVVTLKSC

72.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide

Lanthipeptides: JNUCC31_RS17165_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQ ETTPVCAVAAT AASSA C VGGGI GVT+V+++K C

GDVQPETTPVCAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

72.7%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11330_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

DVQ ETTPVCAVAAT AASSA C VGGG+ GVTVV++LK C

ADVQPETTPVCAVAATVAASSATCAAVGGGVAVGVTVVLTLKTC

70.5%

NZ_KB946334.1and 1 other:

NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide

Lanthipeptides: UC7_RS10245_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

GDVQAETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

68.2%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10240_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQ ETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

GDVQVETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

68.2%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08835_lanthipeptide

DVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

DVQ ETTP+CAVAAT AASSA C VGGGI GVT+V+++K C

DVQPETTPICAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

65.9%

NC_014098.1:

Lanthipeptides: BTUS_RS14190_lanthipeptide

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

GDVQAETTP+C AAT ASSAAC VG GI GVT+V+++K C

GDVQAETTPICYTAATVTASSAACAGVGAGIVAGVTIVLTIKRC

KKP64_RS02155

Leader:

MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS

Core:

GDVQAETTPACFTIGLGVGALFSAKFC

Core with dehydrations:

GDVQAEDhbDhbPACysFDhbIGLGVGALFDhaAKFCys

antiSMASH-DB 4.0 matches for KKP64_RS02155

100.0%

NZ_AP026721.1and 35 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptideNZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide

Lanthipeptides: PO855_RS02215_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

85.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide

Lanthipeptides: BEH_RS02100_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFTIGLGVGAL SA C

GDVQAETTPVCFTIGLGVGALVSAAGC

77.8%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide

Lanthipeptides: IKS_RS03655_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFT+GLGVG+L SA C

GDVQAETTPVCFTVGLGVGSLVSASVC

with 108 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide

Lanthipeptides: IKS_RS03660_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQAETTP CFT+GLG+G+L SA C

GDVQAETTPVCFTVGLGIGSLVSASVC

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

GDVQAETTPAC-FTIGLGVGALFSAKFC

GDVQ ETTP C FTIG+G+GAL S K+C

GDVQPETTPICGFTIGIGIGALASVKWC

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

GDVQAETTPAC-FTIGLGVGALFSAKFC

GDVQ ETTP C FTIG+G+GAL S K+C

GDVQPETTPLCGFTIGIGIGALVSVKWC

70.0%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

GDV+ ETTPAC FTIGLG+GAL SA C

GDVKPETTPACLAGFTIGLGIGALASAAGC

66.7%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

GDV+ ETTPAC FT+GLG+GAL SA C

GDVKPETTPACLAGFTVGLGIGALASAAGC

63.0%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

GDVQ ET+PAC TIG+G+G S FC

GDVQPETSPACVTIGIGIGIGISKLFC

59.3%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

DVQ ETTPAC T L G +FS K+C

SDVQPETTPACVT-ALTTGIIFSIKWC

58.6%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

GDVQAETTPAC---FTIGLGVGALFSAKFC

DVQ ETTPAC FTIG V +FS + C

SDVQPETTPACAVAFTIGATV--IFSVRNC

57.1%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11325_lanthipeptide

DVQAETTPAC-FTIGLGVGALFSAKFC

DVQ ETTP C F +G+G+GA+ SA C

DVQPETTPVCGFFVGVGIGAIISATAC

55.6%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

GDVQAETTPACFTIGLGVGALFSAKFC

DV ETTPAC G LFS KFC

SDVAPETTPAC-VAAFATGLLFSIKFC

MIBiG 4.0 matches for KKP64_RS02155

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

TTPACFTIGLGVGAL-------FSAKFC

T PA + LG+ A+ SA FC

TDPAVTGLILGIVAIQAGVAVGVSAAFC

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

TPACFT

TP C T

TPGCKT

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

PACFTIG

PAC T+

PACHTLS

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.28 out of 27.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.15 out of 20.97

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.64 out of 32.93

Confidence: medium

Additional weak hits (1):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.44 out of 23.43

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

KKP64_RS02150 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 4017.0 Da

Molecular weight: 4019.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4037.6 Da N = 1; 4055.6 Da N = 2; 4073.6 Da N = 3; 4091.6 Da N = 4; 4109.6 Da N = 5

KKP64_RS02155 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 2630.3 Da

Molecular weight: 2632.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2650.0 Da N = 1; 2668.0 Da N = 2

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
LexA variant 3	Repressor of DNA damage response

NZ_CP075604.2 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 985,209 - 1,006,090 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

KKP64_RS04890: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

KKP64_RS04925: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

KKP64_RS04925: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.34 out of 32.93

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.98 out of 18.16

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.19 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.33 out of 27.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Additional weak hits (2):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.16 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.47 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP075604.2 - Region 3 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1,478,482 - 1,489,363 nt. (total: 10,882 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

Additional weak hits (1):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.00 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A

NZ_CP075608.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 9,687 - 20,061 nt. (total: 10,375 nt) Show pHMM detection rules used

Region on contig edge.

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000523.3	0.37	ribosomal	lactocin S	Lactobacillus sakei
BGC0002586.2	0.35	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0000487.5	0.31	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000626.3	0.31	ribosomal	thuricin	Bacillus thuringiensis
BGC0000539.5	0.31	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001229.4	0.28	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.27	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000607.5	0.25	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0000598.5	0.22	ribosomal	polytheonamide A, polytheonamide B	Candidatus Entotheonella factor
BGC0000326.5	0.19	NRPS	isocomplestatin	Streptomyces lavendulae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000523.3	0.37	ribosomal	lactocin S	Lactobacillus sakei
BGC0002586.2	0.35	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0000487.5	0.31	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000626.3	0.31	ribosomal	thuricin	Bacillus thuringiensis
BGC0000539.5	0.31	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001229.4	0.28	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.27	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000607.5	0.25	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0000598.5	0.22	ribosomal	polytheonamide A, polytheonamide B	Candidatus Entotheonella factor
BGC0000326.5	0.19	NRPS	isocomplestatin	Streptomyces lavendulae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.88 out of 26.85

Confidence: medium

Additional weak hits (3):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.69 out of 27.55

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.45 out of 29.51

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.75 out of 33.73

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
RutR	Regulator of the pyrimidine and purine metabolism