LOCUS       NZ_CP076538            22646 bp    DNA     circular CON 16-DEC-2024
DEFINITION  Amycolatopsis aidingensis strain YIM 96748 chromosome, complete
            genome.
ACCESSION   NZ_CP076538
VERSION     NZ_CP076538.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis aidingensis
  ORGANISM  Amycolatopsis aidingensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     YIM 96748 draft genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2021) Yunnan University, Yunnan Institute of
            Microbiology, 121 Street, Yunnan 650000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdevono v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018885265.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 14:59:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,118
            CDSs (total)                      :: 7,060
            Genes (coding)                    :: 6,941
            CDSs (with protein)               :: 6,941
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 119
            CDSs (without protein)            :: 119
            Pseudo Genes (ambiguous residues) :: 0 of 119
            Pseudo Genes (frameshifted)       :: 44 of 119
            Pseudo Genes (incomplete)         :: 87 of 119
            Pseudo Genes (internal stop)      :: 2 of 119
            Pseudo Genes (multiple problems)  :: 13 of 119
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:56:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7048684
            Orig. end                         :: 7071330
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP076538.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22646
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="32"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22646
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22646
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12646](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12646)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     gene            complement(684..1646)
                     /locus_tag="KOI47_RS32405"
     CDS             complement(684..1646)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156743.1"
                     /locus_tag="KOI47_RS32405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glutamate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_232376398.1"
                     /transl_table=11
                     /translation="MSKRGLPRKLFAVLGTLAVLATGCGSPGEPVDPAPVGSVQRPEPA
                     GSGPVDVDSEKSESPDCNATASLPPQAGIPAGSTMAEIRERGHLVAGVDQNTFLFGFRN
                     PTTGKLEGFDIDIAKEIARAIFGDPEKIRFQAITSAQREDVLMNGEVDVVVRTYTVNCA
                     RRDKVNFSSVYYVAGQRLLVDKTSSVTSLAGLEGERVCAAKGSTSLKNIAAVSGPIPVQ
                     VNDWSDCLVMLQQGQVAAVSTDDTILAGMAAQDPTTKVVGETFTEEPYGVGIPKENEDM
                     VRFVNHVLELVRGGRWQQSYDEWVAERLGPASPPQPEYR"
     gene            complement(1643..3061)
                     /locus_tag="KOI47_RS32410"
     CDS             complement(1643..3061)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030775.1"
                     /locus_tag="KOI47_RS32410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_232376399.1"
                     /transl_table=11
                     /translation="MTSTATRAAGEHGAQAAGTPGPGGHGAPAQSRSGLAGLAELPAGA
                     VRRIVRATRRTPGRLSLIAVGLIVLALLTGVFGTIAMQDRKGSIDGLIEHREPLAAAAQ
                     EVYRSLSDADATAASSFLFTGGEPRQLRERYELDIAKAGAALAKAASDSAGVGDAATQV
                     DILSQQLPVYTGLVEQARANNLQGFPVGASYLREASHLMRSTLLPAAEELYRIDTQRLA
                     AEQDDASGFPWLTALLVLALLGALIAAQVHIKRSTNRVFNIGLVVATIAVGVAILWTAA
                     ALIVQSVLVSAGRDSTEQVDQLVQARITALKARADETLTLVARGGGDEYEKEFVQLSAE
                     LAGPDGEGGMLERARNLTAGEPAAEPTAAAAEDASAWLRAHTEVRSLDQAGNHDRAVGL
                     AMDSTDEQSAAAAFTRLDGHLAEAINAARQGFLDDTTNGSRALILLAPGFAVLAVIAAL
                     GVTMGIRERLREYR"
     gene            complement(3179..3826)
                     /locus_tag="KOI47_RS32415"
     CDS             complement(3179..3826)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643877.1"
                     /locus_tag="KOI47_RS32415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_216210864.1"
                     /transl_table=11
                     /translation="MGEPIRVLVVDDQQVIREGLVALLGLVEGVQVTGSAAEGAAALES
                     LARERADVVLMDLRMPGLDGVAATERINREFPGTAVVVLTTYSDDDSIAGALRAGARGY
                     LTKDAGRGEITAALHSAAAGQSTFAADVSSRLVAALDPPTGDRKPPDGLTAREAEVLGL
                     IGAGLSNAEIAGRLFIGETTVKTHINNAFAKIGVRNRAEAVRYAYRNDLSGS"
     gene            complement(3819..4961)
                     /locus_tag="KOI47_RS32420"
     CDS             complement(3819..4961)
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007030773.1"
                     /locus_tag="KOI47_RS32420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_216210866.1"
                     /transl_table=11
                     /translation="MTEAKRRWRLPDNLAPGWLVVQVFGTVFLAVTLLTAREDEPWIWA
                     CYGACAVCWTVFVLAGARAPRFSAAMLGVAAALPALAAGPAADMTPAILGAIALGRFAA
                     LETPGVSTIVLTGVGGALLATASGVLAGSPVAEALVTPGVLLLFMLFGLHQRQDRVRAR
                     QAEQLLEQTRLAQAEHARAAALDERTRIAREIHDVLAHSLGALGVQLELAEAQLAEKSD
                     VEGSLGTVRRARRLAADGLAEARNAVAALRKDVPALTEALAELAGRHRADHGTPVEFRT
                     EGVPRAVSSAAAVSLSGIAREALTNAARHAPGAAVAMVLEFGSGRVSLRVLNERTGNQV
                     VRPQGFGLTGLRERIALAGGTLTAGGEGRTWRVSAEVPDG"
     gene            complement(4996..5139)
                     /locus_tag="KOI47_RS32425"
     CDS             complement(4996..5139)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS32425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216210867.1"
                     /transl_table=11
                     /translation="MDNTGRDDKRTGGRALLLLIGVGVLLLLGFLAYRLLLVEIITSLS
                     GR"
     gene            complement(5284..5487)
                     /locus_tag="KOI47_RS32430"
     CDS             complement(5284..5487)
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0001072 - transcription antitermination
                     factor activity, RNA binding [Evidence IEA]"
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1255: cold-shock
                     DNA-binding domain protein"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_024365900.1"
                     /locus_tag="KOI47_RS32430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cold-shock protein"
                     /protein_id="WP_141999167.1"
                     /transl_table=11
                     /translation="MTQGTVKWFNSEKGFGFITPDQGDGDVFVHYSEIKGNGFRTLEEN
                     ARVEFEIGQGQKGPQATSVSVI"
     misc_feature    complement(5490..5510)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.56"
                     /tool="antismash"
     misc_feature    complement(5499..5512)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.22"
                     /tool="antismash"
     misc_feature    complement(5504..5513)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    5588..5603
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.4"
                     /tool="antismash"
     misc_feature    5602..5615
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.74"
                     /tool="antismash"
     misc_feature    complement(5650..5664)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.32"
                     /tool="antismash"
     misc_feature    5686..5704
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.5"
                     /tool="antismash"
     misc_feature    complement(5849..5864)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            5893..6315
                     /locus_tag="KOI47_RS32435"
     CDS             5893..6315
                     /EC_number="3.1.2.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222286.1"
                     /locus_tag="KOI47_RS32435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioesterase family protein"
                     /protein_id="WP_216210869.1"
                     /sec_met_domain="4HBT_2 (E-value: 8.4e-16, bitscore: 57.2,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTSYPHWETVPTRWKDNDVYGHMNNAVHYSIMDTVINTWLIREG
                     GLDIHAGDTIGLCVESHCNYHAATAFPESLAVGLRVGKLGGSSVRYEVGIYREDRETVV
                     AEGHFVHVFVDRETRRPRPISGRLRDSLAALLVEPG"
     gene            complement(6263..8023)
                     /locus_tag="KOI47_RS32440"
     CDS             complement(6263..8023)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642935.1"
                     /locus_tag="KOI47_RS32440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_216210871.1"
                     /transl_table=11
                     /translation="MTVTKLYWTTLGKQWRGGLVLLVCSVLEGAPAFLSGRLVQLAVDD
                     GFGAGRPAIGVGWLLVFGAVAVLGAFGSRLVWRRLGSIIEPLRDTMVGAVVRGVLRGGA
                     AHRHRPDASGVARITQHIEVIRDATAGLLVQARGMVVTTVSALAGLFTVAGTLAWAVAV
                     PVVLSVAVFVGLLPTLASRQRALAIADEGTAESAGEVLAGLRDVVACGAEPAAIAAVDS
                     RIEAQARAKVRMAVATAMRTLVIAVGAFVPLVLVLVMAPGMVAAGQLTAGAALGSLVYL
                     ASTMQPALQGLASTASTVVLRLLVALRRLGEAGAGGDEPAPEGGTRVPEGRELVASGLT
                     FGWGAHAEPIVTGLDLELGPGDHLAVVGPSGIGKSTLAGLITGMLAPQRGQVLLGGVPV
                     REIRPEARHRLIALTPQESYVFAGTVRENLSLFAPSASESHLLAAAEAVGASRLLERLG
                     GLNGSVAHGGEGLSTGEVQLLALARLYASPAEVIVLDEATANLDAAAEARAERAFAARG
                     GVLVVIAHRLSSALRANRVLVMDGRDTLLGGHDELLVSSPRYAELMQAWEGSFTRVPPA
                     APPASRVAAH"
     gene            complement(8020..9708)
                     /locus_tag="KOI47_RS32445"
     CDS             complement(8020..9708)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669539.1"
                     /locus_tag="KOI47_RS32445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_408629964.1"
                     /transl_table=11
                     /translation="MRAPGDRVLLAVLRHDPPRLLLLALMAVIATTAGLLLPGALADAV
                     DAAVAAERSWPQVLWLLTLGISEIVADVAAVIITARVTAGAGAWLRRRLTRQLTGLGTR
                     SPFVAGDAVSRVTTDCAGAAEISSILVQLCSAVVVSTGAIVLLALLDWRLAVVFLGSVP
                     IALLLARSHLRLTAADVLSYQQVSGDLSARLLDAVGGLRTIAASGTAEREAARVLRPLP
                     RLAAAGIGMWRTQARMVWRAGLLLPAVQLGVLTAAGFGVLAGRLSIGDVLAALGYVVLG
                     MSLVQQIPLLTTLSRARGCGTRLAEVLDSPLPRDGDRPLPAGHGEIELRGVGVDGALEG
                     IDLTVPAGTSLAVVGRSGAGKTALAAVLGGLRPPDRGAALLHGVPVDQLPAEDVRAAVG
                     HAFERPALLGATVQDAVAYGSWAGPSAVREACRAAQVHDLVVRLPEGYRTPLEQTPLSG
                     GEAQRLGLARALARKPRLLVLDEATGSLDTVTESMVEDAIESTLPGRTRVVVTHRAGTA
                     RRADRVLWLEDGRIRACAPHAELWSEPEYRSVFTEEETEAGTGTS"
     gene            complement(9836..9979)
                     /locus_tag="KOI47_RS32450"
     CDS             complement(9836..9979)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949109.1"
                     /locus_tag="KOI47_RS32450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_216210873.1"
                     /transl_table=11
                     /translation="MEHVLDLQNLESADAPEYGGPSHGGGGSNLSLIASCANSTVSLLT
                     CH"
     CDS_motif       complement(9938..9979)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEHVLDLQNLESAD"
                     /locus_tag="KOI47_RS32450_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9836..9937)
                     /prepeptide="core"
                     /locus_tag="KOI47_RS32450_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="2.70"
                     /molecular_weight="3014.3"
                     /monoisotopic_mass="3012.5"
                     /core_sequence="APEYGGPSHGGGGSNLSLIASCANSTVSLLTCH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEHVLDLQNLESAD"
                     /leader_location="[9937:9979](-)"
                     /alternative_weights="3032.3"
                     /alternative_weights="3050.3"
                     /alternative_weights="3068.3"
                     /alternative_weights="3086.4"
                     /alternative_weights="3104.4"
                     /alternative_weights="3122.4"
     gene            complement(10001..12646)
                     /gene="lanKC"
                     /locus_tag="KOI47_RS32455"
     CDS             complement(10001..12646)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658751.1"
                     /locus_tag="KOI47_RS32455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_216210875.1"
                     /sec_met_domain="micKC (E-value: 0.0, bitscore: 1125.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.8e-08, bitscore: 32.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-12, bitscore:
                     46.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLRYEAFCFADPLFFDEQRESATAEDVLGHELEQPDSGWLREDM
                     GVWRMLRPTSGPLPEQGWKIHVSACLDNAERVLTTVHEYCLAHKISFKYLRTRSILLAR
                     NSKYAPRSASGKLITIYPADDGQFERVLADLSGKLDGEEGPYILSDLRYGKGPLFVRYG
                     GFVERWVEADGTRVLAIRKSDGTLVPDKRGPSFVVPDWVDLPECLEPHVAARKGGDPAD
                     FPYRVTRSLHFSNGGGVYQAERLADGKELVLKEGRPHAGLDRDQADAVTRLQREYDILT
                     RLAGIEGIPEVYDLFTVWEHHFLAMEYVRGRPLGSWLSRNYPLTRGDIDEREVADYTRR
                     ALGLLDSVTRLISEVHERGVVFGDLHALNIMVDDEAGQEGQEAGDTKHTAGSPRISLID
                     FELAAPVDTGGRPALGAPGFRAPRDRTGFQIDEYALAALRLWLFLPVNALLELSPAKLF
                     PLVEFVERRFPVPAGFGESVLNVLAPRDEQGARLAPASTELDQPEPDWGMVRKSLAEAI
                     LASATPERADRLFPGDIEQFRVGGTCFGYGAAGVLHALEVTGAGRYPEHERWLIEAVRR
                     ERPARPGFYDGAHGIAYVLENLGHSEEATAVLDGAANLVEQTQDHSLDGGLAGIALNLR
                     HFAATRQDADFRAHAMRIGDRLAEAVAGAEAPGGFARAGLLHGWSGPALLFLRLYDDTG
                     EESWLDLAEQALQRDLAEGVLADDGSLQVRDGGARTLPYLAIGSAGVAIVAGELAEYRP
                     GAESAARIPELLKACRGEFVVHPSLLFGRAGLMVTLAEADRRAPDPVLAESVNRHLSRL
                     AWHGIPFGEDGIAVPGNQLLRLSMDLKTGGAGLLLALASTVDGHGPVLPFLGTPGRPPR
                     TPGQSPAGGK"
     misc_feature    complement(12296..12298)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12863..12878)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.66"
                     /tool="antismash"
     misc_feature    12970..12983
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.05"
                     /tool="antismash"
     misc_feature    12971..12984
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.76"
                     /tool="antismash"
     misc_feature    12972..12985
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.99"
                     /tool="antismash"
     misc_feature    13128..13144
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.12"
                     /tool="antismash"
     misc_feature    13131..13147
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.59"
                     /tool="antismash"
     gene            13156..13521
                     /locus_tag="KOI47_RS32460"
     CDS             13156..13521
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005460146.1"
                     /locus_tag="KOI47_RS32460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_216210877.1"
                     /transl_table=11
                     /translation="MVTWLATAVALCSLAVACWSFVSAARGRSPKDPLLVAIAVLEVLL
                     LAQVVVAVVLLISGDRPGSMATFIAYLIGSLAVLPVATLWALAERSRSSTVVLGVACVT
                     VPVLILRMHEVWGGAGA"
     gene            13514..13936
                     /locus_tag="KOI47_RS32465"
     CDS             13514..13936
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005460147.1"
                     /locus_tag="KOI47_RS32465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_216210879.1"
                     /transl_table=11
                     /translation="MPEDRAERAAPRTASGPGRVLVAVYAIFAVAATSRAAVQIATRFE
                     EAPLAYLLSAFAAVVYLLATLALARSGRAWWRIALAACSVELAGVLTVGTLTVFDAAAF
                     PDATVWSNYGRGYLFIPLVLPAIGLYWLRRTGRATR"
     gene            complement(13926..14273)
                     /locus_tag="KOI47_RS32470"
     CDS             complement(13926..14273)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156754.1"
                     /locus_tag="KOI47_RS32470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_216210881.1"
                     /transl_table=11
                     /translation="MEIVYDLLVVLHLLGMAGILSGLMTYAYAQTPKAFTIIAHSAATQ
                     LVTGVAMVGIASADLVGAEVNHIKIGVKLLIALIVLVLGYTAVRKQAASRNLLTAITLL
                     TIANVAIAVIW"
     misc_feature    complement(14259..14270)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.58"
                     /tool="antismash"
     misc_feature    14275..14291
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.32"
                     /tool="antismash"
     gene            complement(14306..15226)
                     /locus_tag="KOI47_RS32475"
     CDS             complement(14306..15226)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156755.1"
                     /locus_tag="KOI47_RS32475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_216210883.1"
                     /transl_table=11
                     /translation="MTIVLHHLAALLVAAVVVLWLWHGRWTHAHPRTALVLWQVVGLTV
                     VVSTVGALLGIGLAPYELGLVPALGALAADLAAGELWRTVDPAHLGIAAAGLALACWLI
                     GNQIVCLLRTNRLRARHRAILNLVAHSAADALVVDHPIAVAYCLPGRTPRIVVSAGARH
                     LLTGVELDAVLAHERAHARERHDLVLAPFHALHRLWPHGRLLGRVCAAIALLVEMCADD
                     RAASQHGAEPLASALERFHRNGSGGTPAGALAAIDDNVETRIRRLRQPVHAAWAGHSAA
                     PIRLLAVLVALVALGTSASLFVVPA"
     gene            complement(15223..15597)
                     /locus_tag="KOI47_RS32480"
     CDS             complement(15223..15597)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156756.1"
                     /locus_tag="KOI47_RS32480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BlaI/MecI/CopY family transcriptional regulator"
                     /protein_id="WP_216210885.1"
                     /transl_table=11
                     /translation="MLVGRLGELERAVMDVLWAHGEPLSVRAVHEGLADRDLAYTTVMT
                     VLSRLAAKNIVRRERAGRAWLYAPLASREEYVAELMLEALALTGDRDSALVRFAHSVSS
                     DEADALRKALAPPRDEGDAR"
     gene            complement(15761..16237)
                     /locus_tag="KOI47_RS32485"
     CDS             complement(15761..16237)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.5"
                     /locus_tag="KOI47_RS32485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NUDIX hydrolase"
                     /protein_id="WP_269756680.1"
                     /transl_table=11
                     /translation="MTISTPRVAAGVICIDDQSRVLLVRPTYKDYWDVPGGYVTQGESP
                     RDAAIREVREELGVDVRIGHLLAVDWAPSVKDGDKLLFLFSGQLPSDAVFSFADGEIDE
                     TRYVDVDELEGLTIDRLCRRIRSSIEASVSTYLEHGVAVRGAATPGTGTANSPT"
     misc_feature    16191..16204
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 20.8"
                     /tool="antismash"
     gene            complement(16254..17870)
                     /locus_tag="KOI47_RS32490"
     CDS             complement(16254..17870)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942524.1"
                     /locus_tag="KOI47_RS32490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CdaR family transcriptional regulator"
                     /protein_id="WP_216210889.1"
                     /transl_table=11
                     /translation="MVEDARSTGGVTLRQLLVSVGDPLVDLHVAGAGLDLRVRGVSILD
                     PDDQPGAYPAELVLVIGARGRDAIRFVRAAARGGAVATAVKAGQDGHAEDLRAAAAEAG
                     IALLAVRPGVRWEQLETLLREVLDSAALSAGFGADMPLGDLFSLAQTVAVLTGGSVSIE
                     DAGNRVLAYSRSDDEVDELRRLSILGWEGPEAYLAMLREWGIFQRLRAGEEVVRIDENP
                     ELGIRRRLAIGIRAGSHHLGTIWVQEGREPFADRAERALVGAARMAAMQLLRHRSDAHP
                     AGPGRDLLPGLLDGRASADLVAGHLGLDPATSAAVLAFALPTGPDLPAHELHLAEAGTV
                     VSVHATSYRRAALVGTIGSRVYAVLPEVTARQERAVSALAADIVDVLRRRVGTRVQAGI
                     GSPVGTLGAVAASRAEADRVLDAMARKPDARVATIAQLRAEVLLGETLTLLAGKPDLRD
                     PGVAALREHDAAHGSDLAGSLLAYLDAMGDVRSAAGKLHIHPNTLRHRVRRAGKVSGID
                     LDDPRARLSCHLQLLLVTRAD"
     misc_feature    complement(17827..17840)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.64"
                     /tool="antismash"
     gene            17991..19616
                     /gene="pruA"
                     /locus_tag="KOI47_RS32495"
     CDS             17991..19616
                     /EC_number="1.2.1.88"
                     /GO_function="GO:0003842 - 1-pyrroline-5-carboxylate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0010133 - proline catabolic process to
                     glutamate [Evidence IEA]"
                     /codon_start=1
                     /gene="pruA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075672.1"
                     /locus_tag="KOI47_RS32495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="L-glutamate gamma-semialdehyde dehydrogenase"
                     /protein_id="WP_216210890.1"
                     /sec_met_domain="Aldedh (E-value: 2e-100, bitscore: 335.2,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAITTTPAPRNEPVRDYAPGSPERESLVAKVSELAGKQHELTVT
                     IDGEQRLGGGRQIDVVQPHRHAHVLGSMGNATQADAKSAVQAALRAAESWRRLPFDERA
                     AVLLRAADLLCGPWRDTLNAATMLGQSKTVQQAEIDSACELADFWRFNVHYARQILTEQ
                     PVSSPGVWNRLDYRPLEGFVYAVTPFNFTAIAGNLPTAPALMGNTVLWKPAPTQGLAAH
                     LTMRLLEEAGMPPGVINLLTGDGIEVSEVVLNDPALAGLHFTGSSQTFQHLWATVGTNI
                     ANYHTYPRLVGETGGKDFVLAHPSADIDVLRTALVRGAFEFQGQKCSAASRAFVPRSVW
                     DRMRDDFVSEVDSLSMGEVTDLGNFMGAVIDRRSFDRLAGVLKMAHTDPTLEVVAGGTA
                     DDSAGYFVRPTVLVGSDPTHEVFRTEYFGPVLAVHVYPDEDFERILRELDQGTSYGLTG
                     AFIARDRQAIARASEALRFSAGNFYVNDKPTGAVVGQQPFGGARASGTNDKAGSVYNLL
                     RWASPRTIKENFVPPVTSGYPHQR"
     gene            19630..20556
                     /locus_tag="KOI47_RS32500"
     CDS             19630..20556
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003068848.1"
                     /locus_tag="KOI47_RS32500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="proline dehydrogenase family protein"
                     /protein_id="WP_216210892.1"
                     /transl_table=11
                     /translation="MLRSALIAASKSAGVRSLAERTPLVRPIVDRFVAGTGVEAAIHTA
                     AELSTDRFVSLDHLGEDTGDRAQADATVQAYRALLARLADTGLASRAEVSVKLSALGQA
                     LAIDGDKIALENARLICAAATAAGTTVTVDMEDHTTTDSTLAIVRDLRLDYPDTGAVLQ
                     AYLRRTEADCRDLAGPGSRVRLCKGAYNEPESVAFRDKSEVDKSYVRCLRVLMAGEGYP
                     MVATHDPRLIDIGKELARRAGRGGTDYEFQMLYGIRQAEQRALAASGLRMRVYVPYGTE
                     WFPYFMRRLGERPANLAFFARSFLTRS"
     gene            complement(20624..20881)
                     /locus_tag="KOI47_RS32505"
     CDS             complement(20624..20881)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466826.1"
                     /locus_tag="KOI47_RS32505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Prokaryotic metallothionein"
                     /protein_id="WP_216210895.1"
                     /transl_table=11
                     /translation="MATCEVCGNDYDLAFEVHTRDGGRHTFDSFECAINRLAPICEHCS
                     CRVIGHGVQVDGRFYCCAHCARQAGPTGKEARDAVTTTSA"
     gene            complement(20955..21743)
                     /locus_tag="KOI47_RS32510"
     CDS             complement(20955..21743)
                     /NRPS_PKS="Domain: ECH (8-253). E-value: 9e-39. Score:
                     125.2. Matches aSDomain:
                     nrpspksdomains_KOI47_RS32510_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020670101.1"
                     /locus_tag="KOI47_RS32510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="crotonase/enoyl-CoA hydratase family protein"
                     /protein_id="WP_216210896.1"
                     /transl_table=11
                     /translation="MSERVTVQRDGHVLLIGVNRPEKRNAWDLATISAVSAAYDQLADD
                     PELRAGVLFGHGDHFCAGLDLADVSPAVAEHGPGALSGDGRHDPFGLWNEPVGKPVVLA
                     VQGIAFTLSIELALASDIVVSAEDVRFRQLEIGRGILPFGGATLRAPAQLGWGNAMRFL
                     LTGEEFGAAEAHRIGLVQEVVPAGEQLERATELARVIAAQAPLGVQGTLANARLAQRAE
                     SERAAADHLRELLPGILASEDAREGLQSFVERREARFTGR"
     aSDomain        complement(20985..21719)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KOI47_RS32510_ECH.1"
                     /evalue="9.00E-39"
                     /label="KOI47_RS32510_ECH.1"
                     /locus_tag="KOI47_RS32510"
                     /protein_end="253"
                     /protein_start="8"
                     /score="125.2"
                     /tool="antismash"
                     /translation="RDGHVLLIGVNRPEKRNAWDLATISAVSAAYDQLADDPELRAGVL
                     FGHGDHFCAGLDLADVSPAVAEHGPGALSGDGRHDPFGLWNEPVGKPVVLAVQGIAFTL
                     SIELALASDIVVSAEDVRFRQLEIGRGILPFGGATLRAPAQLGWGNAMRFLLTGEEFGA
                     AEAHRIGLVQEVVPAGEQLERATELARVIAAQAPLGVQGTLANARLAQRAESERAAADH
                     LRELLPGILASEDAREGLQSFVE"
ORIGIN
        1 ttggcgaggt agatccagcc gagcccgccg taggccagcg cgccgagcac ctcgtactgc
       61 ccgccgacca cctcgccggg ccgcagcttc ggcagaaagg agaacgaggc gccgcacttc
      121 gggcacctgc cctccggctc gcccggtttg ccgtccttgc cccggccgac cttcgcctgg
      181 cagctgccgc agaaccgttt ctcctccgac accaccgggt tcgccagcac ggccgatgcc
      241 gggtcccggt agggcacctg cggcacgtcc accaggccgg caccgagcct gccgcggcgc
      301 gaggtccgcg cggaactgcg ccgggaggtg ccggggaagg tgccgggtcc ggtaccgggc
      361 cctgttcccg gccacgagcc cggctcgctg ccaggggtgc tgccgggacc ggtgcccggc
      421 ctgctgcccc cgctggtgct cggcggcagc acgctctccg ttccggggtc cggcaagggc
      481 acgtccgagc ccggttccac cgcgggtgcg ggcggcgcga tactcctggt ctccgcgggc
      541 gcgttcagca cactggtcag ctgcgggtcg ccggcagctt gctgcggctg ttgctgcggc
      601 tgctgctggg gtgggcgcgg gggctgctgg ggctgccgct gctcgggctc acgccagacc
      661 tggtccgaca ctgctacctc ccgctacctg tactcgggct ggggcgggct cgccggaccg
      721 agccgttcgg ccacccactc gtcatagctc tgctgccacc ggccgccgcg taccagctcg
      781 agcacgtggt tgacgaaccg caccatgtcc tcgttctcct tggggatgcc gaccccgtac
      841 ggctcctcgg tgaaggtctc gccgacgacc ttcgtggtcg gatcctgcgc ggccatcccg
      901 gccaggatgg tgtcgtcggt ggacaccgcg gccacctgcc cctgctgcag catgaccagg
      961 cagtccgacc agtcgttcac ctgcaccggg atcgggccgg acacggccgc gatgttcttc
     1021 agcgaggtgg agcccttggc cgcgcatacc cgctcgcctt cgaggccggc caggctggtc
     1081 accgaggatg tcttgtccac gagcagccgc tggcccgcga cgtagtacac cgaggagaag
     1141 ttgaccttgt cccgccgcgc gcagttcacc gtgtaggtcc gcaccacgac gtccacctcg
     1201 ccgttcatca gcacatcctc gcgctgggcc gaggtgatcg cctggaaccg gatcttctcc
     1261 gggtcaccga agatcgccct ggcgatctcc ttggcgatgt cgatgtcgaa gccctcgagc
     1321 ttgccggtgg tggggttgcg gaaaccgaac aggaaggtgt tctggtccac cccggcgacc
     1381 agatgcccgc gctccctgat ttcggccatt gtggacccgg cgggaatacc ggcctggggc
     1441 ggcaggctgg ccgtggcgtt gcagtccggc gactccgact tctcgctgtc cacatcgacc
     1501 ggaccggagc ccgcgggctc cgggcgctgc accgaaccca ccggcgccgg atcgaccggc
     1561 tcgccgggcg agccgcaacc ggtggccagc accgccagcg tgcccagcac ggcgaacagt
     1621 ttccttggca atccccgctt gctcaccgat actccctcag ccgttccctg atccccatcg
     1681 tcacgccgag cgcggcgatc accgccagca ccgcgaaccc gggcgcgagc aggatcaggg
     1741 cacgggaccc gttcgtggtg tcgtccagaa agccttgccg cgcggcgttg atcgcctcag
     1801 cgaggtgacc gtccaggcgg gtgaacgccg ccgccgcgct ctgctcgtcc gtgctgtcca
     1861 tcgcgagccc caccgcccgg tcgtggttgc cggcctggtc cagcgaccgg acctcggtgt
     1921 gcgcacgcag ccaggcactc gcgtcctccg ccgcggcggc cgtgggctcg gcggcgggtt
     1981 cacccgcggt caggttccgc gcccgctcca gcatgccgcc ctcgccgtcc ggcccggcca
     2041 gttcggcgct cagctgcacg aactccttct cgtactcatc gccgccgccc cgtgccacca
     2101 gggtcagggt ttcgtccgcc cgtgccttca gcgcggtgat ccttgcctgc accagctggt
     2161 ccacctgctc ggtgctgtct cggcccgcgg acaccagcac gctctgcacg atcaaagccg
     2221 cagcggtcca caggatcgcc accccgaccg cgatcgtggc caccaccagc ccgatgttga
     2281 acacccggtt ggtgctgcgc ttgatatgca cctgcgccgc gatcagcgcg cccagcagcg
     2341 ccagcacgag cagcgcggtc agccacggga acccgctggc gtcgtcctgt tccgcggcca
     2401 gccgctgggt gtcgatccgg tacagctcct cggccgccgg tagcagagtg gagcgcatca
     2461 ggtgcgaagc ctcgcgcaga taggaggcgc cgaccgggaa accctgcagg ttgttcgccc
     2521 gtgcctgctc caccagtccg gtgtagacgg gcaactgctg gctgaggatg tcgacctggg
     2581 tggccgcgtc gccgaccccc gcggagtcgg aggccgcctt ggccagcgcg gcacccgcct
     2641 tggcgatatc cagctcgtac cgttcccgca gttgccgcgg ctcacccccg gtgaacagga
     2701 aggagctggc cgcggtggca tcggcgtcgg agagcgagcg gtacacctcc tgcgccgcgg
     2761 cggcgagcgg ttcccggtgc tcgatcagcc cgtcgatgga gcccttgcgg tcctgcatgg
     2821 cgatggtgcc gaacaccccg gtcagcaggg cgagcacgat cagccccacg gcgatcaggg
     2881 acagcctgcc gggggtgcgg cgcgtggcgc ggacgatccg gcgtacggcg cccgcaggca
     2941 actcggcaag acccgccagc ccggaccggg actgcgcagg cgccccatgg ccgcccggcc
     3001 ccggcgtgcc tgcggcctgc gcgccgtgct ccccggcagc gcgggtcgcg gtgctcgtca
     3061 ttgtgtctac cctccgccca gtcgcgagac tcgcatgacc gtagccgagt ccgcggcggg
     3121 acacgcggtt agccgggtgg tcggttgaac attctccccg gccggcgcat ccgcgtggtc
     3181 aggaaccgga cagatcgttg cgatacgcat accgcacggc ctcggcacgg ttacgaacac
     3241 cgatcttggc gaaggcattg ttgatatgtg tcttgaccgt tgtctcgccg atgaacagcc
     3301 gcccggcgat ctcggcattg ctcagcccgg cgccgatcag cccgagcacc tcggcctcgc
     3361 gagcggtgag accgtccggc ggcttacggt cgcccgtcgg cgggtccagc gcggcgacca
     3421 gcctgctgga gacgtccgcc gcgaaggtcg actggccggc cgcggccgag tgcagcgcgg
     3481 cggtgatctc gccccggccg gcgtccttgg tcaggtaacc gcgcgcaccc gcacgcagcg
     3541 cgcccgcgat cgagtcgtca tcggaatagg tggtgagcac gaccaccgcg gtccctggga
     3601 actcccggtt gatccgctcg gtggccgcca ccccgtcgag ccctggcatc cgcaggtcca
     3661 tcagcaccac gtcggcccgt tcccgcgcca gggactccag cgccgcggcc ccttcggcgg
     3721 cggacccggt cacctgcacg ccctcgacca gcccgagcag cgcaaccagc ccttcccgga
     3781 tcacctgctg gtcgtccacg acgagcaccc tgatcggctc acccatccgg tacctccgcg
     3841 ctcactcgcc aggtccgccc ctcgccgccc gcggtcaggg tgccaccggc cagcgcgatc
     3901 cgctcgcgta gcccggtcag cccgaacccc tgcgggcgca ccacctggtt gccggtgcgc
     3961 tcgttcagca cgcgcaggga cacccggccg gagccgaact ccagcaccat ggcgaccgcc
     4021 gcgccgggcg catgccgcgc ggcgttggtg agcgcttccc ttgcgatccc ggaaagtgag
     4081 acggcggcgg ccgaggacac cgcgcgcggc accccctcgg tgcggaattc caccggcgtg
     4141 ccgtggtccg cgcgatgcct gccggcgagt tcggccagtg cctcggtcag cgcgggcacg
     4201 tccttacgta gcgcggcaac ggcgtttctc gcctcggcaa gcccgtccgc ggccagccgc
     4261 cgcgcgcgcc gcaccgtacc cagtgatcct tccacatcgg acttctcggc gagttgcgcc
     4321 tcggcgagct ccagctggac gccgagggcc ccgagggaat gcgcgagcac atcgtggatc
     4381 tcccgcgcga tccgggtgcg ctcgtcaagc gcggcggcac gcgcgtgctc cgcctgggcc
     4441 aggcgggtct gttcgagcag ttgctcggcc tgccgcgccc gcacccggtc ctgccgctgg
     4501 tgcaggccga acagcatgaa cagcaacagc acccccggtg tcaccagcgc ctcggcgacc
     4561 ggggatccgg ccagtacgcc ggaggcggtg gcgagcaggg cgccgcccac cccggtcagc
     4621 acgattgtgc tgacgccggg tgtctcgagc gcggcgaacc tgccgagcgc gatggcgccg
     4681 aggatggccg gggtcatgtc ggccgcgggc ccggccgcga gtgcgggcag ggccgcggcc
     4741 acccccagca tggccgcaga gaaccggggt gccctggccc cggcgaggac gaacaccgtc
     4801 cagcagacgg cacaggcgcc gtagcaggcc cagatccacg gctcgtcctc gcgcgcggtg
     4861 agcagggtca ccgcgaggaa caccgtgccg aacacctgca ccaccagcca ccctggcgcg
     4921 aggttgtccg gcagccgcca tcggcgcttc gcttcggtca tctcccgatt ctcggcatcg
     4981 gccgccccgg cgcgctcacc ggccggacag gctggtgatg atctcgacca ggagcagccg
     5041 gtaggccagg aagccgagca acagcagcac acccaccccg atcagcagga gcaatgcccg
     5101 gccgcctgtg cgcttgtcat ccctacccgt gttgtccatg aggcgaacgc taggccgcgg
     5161 ggcgggtgga gcgggaccac tccggggtgg agacgcgggt ggagatgagg agggtgcaga
     5221 caagacggtg cccgccacct cggtgaggtg gcgggcaccg ggaaaaacgt ctgggggtca
     5281 gcctcagatg acgctgaccg aggtggcctg cgggcccttc tggccctggc cgatctcgaa
     5341 ctcaacgcgg gcgttctcct ccagggtccg gaagccgttg cccttgatct ccgagtagtg
     5401 cacgaagacg tccccgtcgc cctggtcggg ggtgatgaaa ccgaagccct tctcggagtt
     5461 gaaccactta acggtgccct gcgtcatgaa aatctcctgt gtgacaaaaa ataaggacga
     5521 caccggccgt aaccgaatgt cctacacagt caagcacacc cgggcgctga acgccaacgg
     5581 ataccagccg aacgtgtgtg tgataactat cctgaaccgc ccgcgaaccg cccggaccag
     5641 ccaagaagaa ataatctgag tatgacgacg agactcgccg gaataattac gaacgagccg
     5701 gaaatgcgcc cagtggccaa aacacgatta ttcctattgg gcgctgctga ggctccgatc
     5761 tacgagcggc tgaccgcgaa acgatgtgcg ccgagaacgc tacccgatcg gcaggccgta
     5821 cgccatgccc cgcgcggcct cctcggggtg agaccggagt cacagcgggt accggtgcgt
     5881 tagcttgccc gcatgcagac ctcctacccg cactgggaaa ccgtgcccac ccggtggaag
     5941 gacaacgatg tctacgggca catgaacaac gccgtgcact actcgatcat ggacacggtc
     6001 atcaacacct ggctgatccg cgagggtggc ctggacatcc atgccggcga cacgatcggc
     6061 ctgtgtgtgg agtcgcactg caactaccac gccgcaacgg ccttccccga gtcgctggct
     6121 gtcggtctgc gggtcggcaa gctcggcggc tccagcgtgc ggtacgaggt cggcatctac
     6181 cgcgaggacc gggagaccgt ggtcgccgag gggcatttcg tgcacgtgtt cgtggaccgg
     6241 gagacccgca ggccccggcc gatcagtggg cggctacgcg actcgctggc ggcgctgctg
     6301 gtggaacccg ggtgaacgag ccctcccatg cctgcatcag ctcggcatag cgcggcgagg
     6361 agaccagcag ctcgtcgtgc ccgccgagca gggtgtccct gccgtccatc accagtaccc
     6421 ggttggcccg cagggcggag ctgagccggt gcgcgatcac cacgagcacc ccgcccctgg
     6481 cggcgaaggc gcgctcggcc cttgcctcgg ccgccgcgtc caggttggcg gtggcctcgt
     6541 ccagcacgat cacctcggcc gggctggcgt agagcctggc cagcgcgagc agctgcacct
     6601 caccggtgga caggccctcc ccgccgtgcg cgaccgagcc gttcaacccg cccagccgtt
     6661 ccagcagcct gctcgcgccc accgcctcgg cggccgcgag caggtgggac tcgctggccg
     6721 acggcgcgaa cagggagagg ttctcccgga ccgtgcccgc gaagacatag gactcctgcg
     6781 gggtgagcgc gatcagccgg tgccgtgcct ccggccggat ctcgcgtacc ggcaccccgc
     6841 caagcagcac ctgcccgcgc tgcggggcga gcattccggt gatcagcccg gccagggtcg
     6901 acttgccgat accactcggc ccgaccacgg caaggtgatc accgggaccg agctcgaggt
     6961 cgaggccggt gacaatgggt tcggcatgcg cgccccagcc gaaggtcagc ccgctggcga
     7021 ccagttcgcg gccctccggc acccgggtgc cgccctccgg cgcgggctcg tccccgcctg
     7081 ccccggcctc gcccagcctg cgcagcgcga ccagcagccg cagcaccacg gtgctcgccg
     7141 tggaagccaa tccctgcagg gcgggttgca tggtgctggc caggtagacc agcgagccga
     7201 gcgcggcgcc cgcggtgagc tgcccggccg cgaccatgcc cggcgccatg accagcacca
     7261 gcaccagcgg cacgaaggca cctaccgcga tcaccagggt gcgcatcgcg gtcgcaaccg
     7321 ccatccggac cttcgccctg gcctgagcct cgatccggga gtccacggcg gcgatcgcgg
     7381 cgggttcggc cccgcaggcg accacatcgc gcaggccggc gagcacctcg cccgcggact
     7441 cggcggtccc ctcgtcggcg atcgcgagtg cccgctgcct gcttgccagg gtgggcaaca
     7501 ggccgacgaa cacggccacc gacagcacca ccggcaccgc gaccgcccag gccagcgtcc
     7561 cggccacggt gaacagcccg gcgagcgcgc tcaccgtggt caccaccatg ccccgcgcct
     7621 gcaccagcag cccggcggtg gcgtcccgga tcacctcgat gtgctgggtg atccgggcga
     7681 ccccactggc gtccggccgg tgccggtgcg cggcgccgcc gcgcagcacc ccgcgcacca
     7741 cggcgccgac catggtgtcg cgcagcggct cgatgatgct gccgagccgc cgccagacca
     7801 gccgggagcc gaacgcgccg agcacggcga ccgcgccgaa gaccagcagc cagccaacgc
     7861 cgatggcagg ccggcctgcc ccgaacccgt cgtccacggc gagctggacc agccgcccgg
     7921 acaggaaggc gggggcgcct tccagcacgg agcagaccag cagcaccagg ccaccgcgcc
     7981 actgcttgcc gagcgtcgtc cagtacagct tcgtgaccgt cacgatgtac ccgtcccggc
     8041 ttcggtctct tcctcggtga acacggatcg gtactccggc tcggaccaca gctcggcatg
     8101 cggcgcgcag gcccggatcc ggccatcctc cagccacagc acccggtcgg cgcggcgcgc
     8161 ggtgcccgcc cggtgggtga ccaccaccct ggtccggcct ggcagggtcg actcgatcgc
     8221 gtcctccacc atgctctcgg tgacggtgtc caggctgccg gtggcctcgt ccagcaccag
     8281 cagtcgcggc ttgcgcgcca gcgctcgcgc cagccccagc cgttgtgcct ccccgccgga
     8341 gagcggggtc tgctccagtg gggtgcggta gccctccggc agccgcacca ccaggtcgtg
     8401 cacctgggcg gcacggcagg cctcccgcac cgcggacggg ccggcccagc tgccataggc
     8461 caccgcatcc tgcacggtcg ctccgagcag tgcgggccgc tcgaaggcgt gccctacggc
     8521 ggcccgtacg tcctcggccg ggagctggtc caccggaacc ccgtgcagca gcgccgcacc
     8581 ccggtccggc ggccgcagtc cgccgagcac ggcggccagc gccgtcttgc cggcacccga
     8641 cctgccgacc acggcaaggc tggtgcccgc aggcacggtg aggtcgatgc cctccagcgc
     8701 gccgtccacc ccgacaccgc gcagctcgat ctcgccatgg cccgcgggca gtggccggtc
     8761 gccgtcccgc ggcaacgggg agtcgagtac ctcggccagc cgggtgccgc agccgcgcgc
     8821 cctggacaac gtggtgagca gcgggatctg ctggaccagg ctcatcccga ggaccacgta
     8881 gccgagcgcg gcgagcacat cgccgatgga gagcctgccg gcgagcaccc cgaaacccgc
     8941 ggcggtgagc acgccgagct gcaccgcggg cagcagcagc ccggcccgcc agaccatccg
     9001 ggcctgggtg cgccacatgc cgatcccggc cgcggccagc cggggcagcg ggcgcagcac
     9061 gcgggcagcc tcccgctccg cggtgccgga ggccgcgatg gtgcgcagcc cgccgaccgc
     9121 gtccagcagc cgggccgaga ggtccccgga aacctgctgg taggagagca cgtcggcggc
     9181 ggtgagccgc aggtgggagc gggcgagcag gagcgcgatc ggcacgctgc cgaggaacac
     9241 cacggccagc cgccagtcca gcagggccag cagcacgatc gcgccggtgg agacgaccac
     9301 ggcggagcac agctgcacca ggatcgagga gatctcggct gcgcccgcgc agtcggtggt
     9361 caccctgctg accgcgtcgc ccgcgacgaa gggggaacgg gtgccgaggc cggtcagctg
     9421 ccgggtgagc ctgcggcgca gccacgcgcc cgcgcccgcg gtcaccctgg cggtgatgat
     9481 cacggcggcc acatcggcga cgatctcgga gatgccgagg gtgagcagcc agagcacctg
     9541 gggccaggag cgctcggcgg cgaccgccgc gtccacggcg tcggcgagcg cacccggcag
     9601 caacagcccg gccgtggtgg cgatcacggc catcagagcg agtagcagca gccgaggggg
     9661 gtcgtgccgc aggaccgcga gcagcacccg gtcaccaggc gcacgcacgc tcgttagtcc
     9721 caccacgccc ctccttgggg aagaatgagt gacgcgggag cggcacactt ggcctgtgcc
     9781 gctcccgcgc cctcgcgtta ccgtccgaat cggcgcttca gcgccggagc gaacctcagt
     9841 ggcaggtcag caggctgacg gtgctgttcg cgcaggaggc gatcaggctc aggttgctgc
     9901 cgccaccgcc gtggctcggg ccgccgtact ccggcgcgtc ggcggactcg aggttctgca
     9961 ggtcgagaac gtgctccatc agtatttcct ttcgggttac ttactttcct ccggccgggg
    10021 attgaccggg ggtccgggga ggacggccag gggtgcccag gaagggcagc accggcccat
    10081 gaccgtccac agtggaggcg agcgcgagca gcagccccgc gccgccggtc ttcaggtcca
    10141 tggagagccg cagcagctgg ttgccgggga ccgcgatccc gtcctcgccg aacgggatgc
    10201 cgtgccaggc cagccgggaa aggtgccggt tgaccgactc ggccagcacc ggatcgggcg
    10261 cgcgccggtc ggcctcggcc agggtgacca tcaggcccgc acggccgaac agcaggctgg
    10321 ggtggacgac gaactcgccg cggcaggcct tgagcagttc cgggatccgc gcggcgctct
    10381 ccgctcccgg ccggtactcg gccagctcac cggccacgat cgcgaccccc gcgctgccga
    10441 tggccaggta gggcagggtg cgcgcgccgc cgtcgcgtac ctgcagcgaa ccgtcgtcgg
    10501 ccaggacgcc ttcggcgagg tcccgttgta gtgcctgttc ggcgaggtcc agccaggact
    10561 cctcgccggt gtcgtcgtac agccgcagga acagcagggc cgggccggac cagccgtgca
    10621 gcagccctgc cctggcgaaa ccgccgggcg cctcggctcc ggccaccgcc tcggccagcc
    10681 ggtcaccgat ccgcatcgcg tgcgcccgga agtccgcgtc ctgccgggtg gcggcgaagt
    10741 gccgcaggtt gagcgcgatc ccggcgaggc caccgtccag gctgtggtcc tgggtctgct
    10801 ccaccaggtt ggcggcaccg tccagcaccg cggtggcctc ctcggagtgc ccgaggttct
    10861 ccagcacgta ggcgatgccg tgcgcgccgt cgtagaagcc cggccgggcg ggccgctccc
    10921 ggcgcaccgc ctcgatcagc cagcgttcgt gctcggggta gcggccggca ccggtgacct
    10981 ccagcgcatg cagcaccccg gccgcgccgt agccgaagca ggtgccgccg acgcggaact
    11041 gctcgatgtc accggggaac agccggtcgg cacgctccgg ggtggcgctg gcaaggatgg
    11101 cctcggccag cgacttgcgc accatgcccc agtccggttc cggctggtcc agttcggtac
    11161 tggccggggc gaggcgtgcc ccctgctcgt cccgcggggc gagcacgttc agcacggact
    11221 cgccgaagcc cgccggcacc gggaagcgcc gttcgacgaa ctcgaccagc gggaacagct
    11281 tcgcgggcga gagctcgagc agcgcgttga ccggaaggaa cagccacagg cgcagcgcgg
    11341 cgagcgcgta ctcgtcgatc tggaatccgg tgcggtcccg tggcgcccgg aagccggggg
    11401 cgccgagcgc gggcctgccg ccggtgtcca ccggagcggc cagctcgaag tcgatcagtg
    11461 agatccgcgg cgacccggcg gtgtgcttgg tgtccccggc ctcttggcct tcttggcctg
    11521 cctcgtcgtc caccatgatg ttcagcgcgt gcagatcgcc gaagacgacc ccgcgctcgt
    11581 gcacctcgga gatcagcctg gtcaccgagt cgagcaggcc gagggcacgc cgggtgtagt
    11641 cggccacctc ccgctcgtcg atgtccccac gggtcagcgg gtagttgcgg gacagccagg
    11701 aaccaagggg gcgcccgcgc acgtactcca tggcgaggaa atggtgctcc cacacggtga
    11761 acaggtcgta cacctcggga atgccctcga tgcccgccag ccgggtgagg atgtcgtact
    11821 cgcgctgcag gcgggtcacc gcgtcggcct ggtcgcggtc caggccggcg tgcggtcggc
    11881 cctccttgag cacgagctcc ttgccgtccg ccaaccgctc ggcctggtac acgccaccgc
    11941 cgttggagaa gtgcagggat ctcgtcaccc ggtaggggaa gtcggcgggg tcgccgccct
    12001 tgcgcgccgc gacatgcggc tcgaggcact ccggaaggtc gacccagtcc gggaccacaa
    12061 aactgggacc acgtttgtcg ggtaccaggg tgccgtccga tttgcggatc gccaggaccc
    12121 gggtaccatc cgcttccacc caccgttcga cgaacccgcc gtagcgcacg aagagcggcc
    12181 ctttaccata acgaagatca ctcagaatat aggggccttc ctcgccgtcg agtttccccg
    12241 aaagatcggc gagcacccgc tcgaactgac cgtcgtcggc cgggtagatg gttattaact
    12301 tcccactcgc cgaacgcgga gcgtatttgg aattacgagc gagcaggatc gaccgggtgc
    12361 gcaggtactt gaaggagatc ttatgtgcga gacagtactc gtgaaccgtc gtcaacaccc
    12421 gttcggcgtt gtcgagacaa gcggaaacat ggatcttcca accctgctcg ggcagaggcc
    12481 ccgaggtggg acgcagcatg cgccacaccc ccatgtcctc ccgtagccag ccggaatccg
    12541 gttgctcaag ttcgtgcccc agcacatcct ccgccgtggc ggactcccgc tgctcgtcga
    12601 agaacagcgg atccgcgaag caaaaagcct cataacggag atccatcaca caacctttcc
    12661 gtcccgcgac ggtatctttc ggccacgctc aacccctccg ggcaaggaag atccgcattg
    12721 cgtatcccgc aaccgattac cgcaacgtcc ggaccatccg cacaacgcct atcccacaac
    12781 aatgggaagg cctgagccaa tccgccatct cagcggttcg gctgggctgt tcagggtacg
    12841 aaaaatctcc tacaccccgg ccgggacaaa acagtgagtg ggcacgtcac tcaccgatat
    12901 cacccggatg agtcgtaaca ctcatctgca ctccaccaat gcaggtgaca gctgtgtgaa
    12961 tgcctgcccc tttttcacac taaagaggag cagaaccgcc gggcactact aacgagtatg
    13021 cgataaaggc cgactttgtc gtgcacctgg ctgagtgtcg accacccgga cgcagcatcc
    13081 tccgccgtac catcggctgg cccaagggga caggtataca ctaccgcttg tagtagtttt
    13141 gctggacgga ggatcgtggt cacctggctc gcgacggcgg tcgcgctgtg ttcactggcc
    13201 gtcgcctgct ggagcttcgt ctcggcggca aggggccgct cgccgaagga cccgctgctg
    13261 gtcgcgatcg cggtgctgga ggtcctgctg ctggcgcagg ttgtggtggc cgtcgtgctg
    13321 ctgatctccg gggatcgccc tggcagcatg gccacgttca tcgcctacct catcggctcg
    13381 ctcgccgtgc tgccggtggc gacgctgtgg gcgctggccg agcggagcag gtcgagcacg
    13441 gtggtgctcg gggtggcctg cgtgaccgtg ccggtgttga tcctgcgaat gcacgaggta
    13501 tggggaggtg ctggtgcctg aggaccgtgc cgagcgcgcc gcgccccgga ccgcgagtgg
    13561 gccggggcgg gtgctggttg cggtgtacgc gatcttcgcg gtcgcggcga cctcccgggc
    13621 ggcggtgcag atcgcgaccc gcttcgagga ggcaccgctg gcctacctgc tgtccgcgtt
    13681 cgcggccgtg gtgtacctgc tggccaccct cgcgctcgcc cgttccggcc gggcgtggtg
    13741 gcggatcgcg ctggccgcct gcagcgtgga actggccggg gtgctcaccg tgggcacgtt
    13801 gaccgtgttc gacgccgcgg ccttcccgga tgccacggtg tggtccaact acggacgggg
    13861 ctacctgttc atcccactgg tactgcccgc gatcggcctg tactggctgc gccggaccgg
    13921 gcgggctacc agataacggc gatcgcgacg ttcgcgatgg tcagcagggt gatcgcggtc
    13981 agcaggttcc ggctcgcggc ctgcttgcgc acggcggtgt agcccagcac cagcacgatc
    14041 agggcgatca gcagcttcac gccgatcttg atgtggttga cctcggcgcc gaccaggtcg
    14101 gccgaggcga tcccgaccat cgccaccccg gtgaccagct gggtggccgc gctgtgcgcg
    14161 atgatcgtga acgccttggg ggtctgggca taggcgtagg tcatcaatcc gctcaggatc
    14221 ccggccatac cgagcagatg cagaaccacg agcaggtcgt agacgatttc catgccggaa
    14281 atgtactaca taacgtagta tgtcttcagg cgggcaccac gaacaggctg gccgaggtgc
    14341 cgagcgcgac cagggcgacc agtaccgcca gcagccggat cggtgccgcc gagtgccccg
    14401 cccacgcggc atgcaccggt tgccgtagcc gccggatccg ggtctcgaca ttgtcgtcga
    14461 tagcggcaag cgcaccggcc ggtgtgccgc cggaaccatt gcggtggaac cgctccagcg
    14521 cgctggcgag tggttccgcg ccgtgctggc tggccgcgcg gtcgtcggcg cacatctcca
    14581 ccagcagcgc gatggcggcg cagaccctgc cgagcaggcg gccatgtggc cacaaccggt
    14641 gcagcgcgtg gaagggtgcg agcaccaggt cgtgccgctc gcgggcgtgt gcccgctcgt
    14701 gggcgagcac cgcgtccagc tcgacgccgg tgagcaggtg ccgggcgccc gcgctgacca
    14761 cgatgcgcgg cgtgcggccg ggcaggcagt aggcgacggc gatcgggtgg tccaccacca
    14821 gcgcgtcggc cgcggagtgc gcgaccaggt tcaggatcgc gcggtgccgg gcccgcaggc
    14881 ggttggtacg cagcaggcag acgatctggt tgccgatcag ccagcaggcc agggccagcc
    14941 cggcggccgc gatgccgaga tgcgccggat caaccgtgcg ccagagctcg ccggcggcca
    15001 ggtcggccgc cagcgcgccg agcgcgggca ccagcccgag ttcgtagggt gcgagcccga
    15061 tgccgagcag ggcacccacg gtcgagacca ccacggtgag cccgaccacc tgccagagca
    15121 ccagcgcggt acgggggtgc gcatgcgtcc agcggccgtg ccacagccac agcaccacga
    15181 ccgcggccac caggagcgcc gcgaggtggt gcaggacgat ggtcaccggg cgtccccctc
    15241 gtcccgtggc ggggcgagcg ccttgcgcag cgcgtcggcc tcgtcgctgc tgaccgagtg
    15301 cgcgaaccgc accagtgccg agtcccggtc cccggtgagc gcgagcgcct ccagcatcag
    15361 ctcggcgacg tactcctccc tgctggccag cggcgcgtac aaccaggccc ggccggcccg
    15421 ctcgcgccgc acgatgttct tggccgccag cctgctgagc acggtcatca ccgtggtgta
    15481 ggcgaggtcc cggtcggcga gcccctcgtg cacggcgcgc acgctcagcg gttcgccatg
    15541 tgcccacagc acatccatca ccgcgcgctc cagctcgccg agcctgccca ccagcacccc
    15601 tctcctgtct ctcctcgccc catcatccca ccccggccca tcggcgtgtt tgccctccac
    15661 atccgcgcgt ttgccgttcc cgcgcacgcg ttggcccttc ccgcacgcga gcccctgctc
    15721 cggcaagcgt gttggccgcc caggtaaccg agtttgccgc tcacgtaggc gagtttgccg
    15781 ttccggtgcc cggggtggcg gcacccctaa ccgccacacc gtgctcgagg taggtggaca
    15841 cagacgcttc gatcgatgac cggatccggc ggcacaaccg gtcgatggtg agcccttcga
    15901 gttcgtcaac gtccacgtat cgtgtttcgt cgatctcgcc gtccgcgaag ctgaaaacgg
    15961 catcggatgg caactgcccg gagaagagaa acaacagctt gtcaccatcc ttcaccgatg
    16021 gcgcccagtc caccgcgagc aggtgcccga tccggacgtc cacaccgagt tcctcgcgta
    16081 cctcccgaat cgccgcgtcg cgtggcgact cgccctgagt cacgtaccca ccggggacgt
    16141 cccagtagtc cttgtaggtc ggccgcacga ggagcacgcg ggactggtcg tcgatgcaga
    16201 tcacgccagc ggcgacacga ggagtggaga ttgtcacgac ttcgggtaac caatcagtcg
    16261 gccctggtca ccagcaggag ctggaggtgg caggacagcc gggctcgcgg gtcgtccagg
    16321 tcgatcccgc tcaccttccc ggcccggcgc acccggtgcc gcagggtgtt cgggtggatg
    16381 tgcagcttgc ccgcggccga gcgcacgtcg cccatggcgt ccaggtaggc cagcagggag
    16441 cccgccaggt cgctgccgtg ggccgcgtcg tgctcgcgca gcgccgcgac cccggggtca
    16501 cgcaggtccg gcttgcctgc cagcagggtg agggtctcgc cgagcagcac ctcggcacgc
    16561 agctgcgcga tggtggccac ccgggcatcc ggcttgcggg ccatggcgtc cagcacccgg
    16621 tcggcctcgg cccgggaagc cgccaccgcg cccagcgtgc ccaccggcga gccgatcccc
    16681 gcctgcaccc tggtgccgac cctgcggcgc agcacgtcga cgatgtcggc ggcgagcgcg
    16741 gagaccgccc gctcctggcg ggccgtgacc tccggcagca cggcgtagac ccgcgacccg
    16801 atcgtgccga ccagggcagc cctgcggtag gaggtcgcgt gcaccgacac cacggtgccc
    16861 gcctccgcca ggtgcagctc gtgcgcgggc aggtccggtc cggtgggcag agcgaaggcg
    16921 agcacggccg cggaagtcgc cggatccagg ccgaggtgcc cggccaccag gtcggcgctg
    16981 gctcgcccgt ccagcagtcc gggcagcagg tcccggccgg gtccggcggg atgggcgtcg
    17041 ctgcggtgcc gcagcagctg catcgccgcc atccgggcgg cccccaccag cgcgcgctcc
    17101 gcccggtcgg cgaacggttc gcggccctcc tgcacccaga tcgtgccgag gtggtgcgag
    17161 cccgccctga tcccgatcgc cagcctgcgc cggatgccca gctcgggatt ctcgtcgatc
    17221 cgcacgacct cctcaccagc ccgcagccgc tggaagatgc cccattccct gagcatcgcc
    17281 aggtaggcct cgggaccttc ccaaccgagg atggacagcc tgcgcagctc gtccacctcg
    17341 tcatcggagc gggagtaggc aagcacccgg ttgcctgcgt cctcgatgct gacgctgccg
    17401 ccggtcagca cggcgacggt ctgcgcgagc gagaacaggt cgcccagcgg catgtccgcg
    17461 ccgaagcccg cagaaagggc ggcgctgtcc agcacctcgc gcagcagggt ctccagctgc
    17521 tcccaccgca cccccggccg gacggcgagc agcgcgatcc cggcctcggc cgcggcggca
    17581 cgcaggtcct cggcatgccc gtcctggcct gccttgaccg cggtggccac cgcaccgccg
    17641 cgggcggcgg cccggacgaa ccggatggcg tcccggcctc gcgcgccgat caccagcacc
    17701 agctcggccg ggtaggcacc cggttggtcg tccggatcga ggatggaaac cccgcgcacc
    17761 cgcaggtcca gccccgcccc ggcgacatgc aggtcgacca ggggatcacc gaccgagacg
    17821 agcaactggc gcagggtgac cccgccggtg gaccgggcat cctcgaccat cgcacccctt
    17881 tgttcgatcg gacagtgggt accccgaaaa ggtagccgat cggacaacca ctggccgggc
    17941 cgcgctgcct aacgtcagcg ggaaacgttc ccgcgcagga ggcaccccga atggacgcga
    18001 tcaccaccac gcccgcgccc cgcaacgaac ccgtgcggga ctacgccccc ggctccccgg
    18061 aacgggagag cctggtcgcc aaggtcagcg aactggcagg caagcagcac gagctcaccg
    18121 tgacgatcga cggtgagcag cgactcggtg gtggcaggca gatcgacgtc gtgcagccgc
    18181 accggcatgc gcatgtcctc ggcagcatgg gcaacgccac acaggcggac gccaagtccg
    18241 cggtgcaggc cgcgctgcgg gcggccgagt cctggcggcg gttgcccttc gacgagcgcg
    18301 ccgcggtgct gctgcgggcg gccgacctgc tctgcggccc gtggcgggac accctgaacg
    18361 ccgccaccat gctcgggcag tccaagacgg tgcagcaggc cgagatcgac tccgcctgtg
    18421 agctggccga cttctggcgg ttcaacgtgc actacgcgcg gcagatcctg accgagcagc
    18481 cggtcagctc gcccggggtg tggaaccggc tggactaccg cccgctggag gggttcgtct
    18541 acgccgtcac cccgttcaac ttcaccgcca tcgccggcaa cctgcccacc gcgcccgcgc
    18601 tgatgggcaa caccgtgctg tggaagcccg cgccgaccca gggcctcgcc gcgcacctca
    18661 ccatgcggct gctggaggag gcaggcatgc cgccaggggt gatcaacctg ctcaccgggg
    18721 acggcatcga ggtctccgag gtggtgctga acgacccggc gctggccggc ctgcacttca
    18781 ccggttcctc gcagaccttc cagcacctgt gggccacggt gggcacgaac atcgcgaact
    18841 accacaccta cccgcggctg gtcggcgaga ccggcggcaa ggacttcgtg ctggcgcacc
    18901 cctccgccga tatcgacgtg ctgcgcaccg cgctggtccg cggcgccttc gagttccagg
    18961 gccagaaatg ctcggcagcc tcccgcgcgt tcgtgccccg ctcggtgtgg gaccggatgc
    19021 gggacgactt tgtgtccgaa gtggactcac tgagcatggg agaggttacc gacctcggca
    19081 acttcatggg cgcggtgatc gaccggcgca gcttcgaccg gctcgcgggc gtgctgaaga
    19141 tggcccacac cgaccccacc ctggaggtcg tggccggggg aaccgccgac gactcggcag
    19201 gctacttcgt ccggcccacc gtgctggtcg gctccgaccc cacacacgag gtgttccgca
    19261 ccgagtactt cgggccggtg ctggcggtgc acgtataccc ggacgaggac ttcgagcgga
    19321 tcctgcggga gctggaccag ggcacctcgt acgggctcac cggtgcgttc atcgcgcggg
    19381 accggcaggc catcgcgcgg gcgagcgagg cgctgcggtt cagcgcgggc aacttctacg
    19441 tcaacgacaa gccgaccggc gccgtggtcg gccagcaacc cttcggcgga gccagggcct
    19501 cgggcaccaa tgacaaggcc ggatcggtct acaacctgct gcgctgggcc agcccgcgca
    19561 cgatcaagga gaacttcgtc ccgccggtca cctccggcta cccgcaccaa cgctgacaag
    19621 gagtcaccca tgctccgttc cgcactgatc gccgcctcga agtcggccgg ggtccgcagc
    19681 ctggccgaac gcaccccgct ggtccgcccg atcgtggacc ggttcgtggc gggcaccggt
    19741 gtcgaggccg ccatccacac ggcggccgaa ctcagcaccg accggttcgt atccctggac
    19801 cacctcggtg aggacaccgg ggaccgggcc caggccgacg ccaccgtgca ggcctaccgt
    19861 gcgctgctcg cccggctcgc ggacaccggt ctcgcatcgc gggccgaggt ctcggtgaag
    19921 ctgtccgcac tgggccaggc gctggccatc gacggcgaca agatcgcgct ggagaacgcc
    19981 cggctgatct gcgcggcggc cacggcggca ggcaccaccg tcacggtcga catggaggac
    20041 cacaccacca ccgactccac cttggccatc gtgcgcgacc tgcggctgga ctacccggac
    20101 accggcgcgg tactacaggc atacctgcgg cgcaccgagg cggactgccg ggatctcgcc
    20161 gggccggggt ccagggtgcg gttgtgtaag ggcgcctata acgaaccgga gtcggtcgcc
    20221 ttccgggaca agtccgaagt ggacaagtcc tatgtgcgct gcctgcgagt actgatggcg
    20281 ggcgagggtt acccgatggt ggccacccac gacccgaggt tgatcgacat cggcaaggag
    20341 ctggcgcggc gggccggtcg cggcggcacg gactacgagt tccagatgct gtacggcatc
    20401 cggcaggccg aacagcgggc gctcgccgcc tccgggctgc ggatgcgggt gtacgtgccc
    20461 tacggcacgg agtggttccc gtacttcatg cgcaggctcg gcgagcggcc cgcgaacctg
    20521 gccttcttcg cccgctcctt cctcaccagg agctgagccg gaccgggggt cgtgcgtgtg
    20581 ccatccgggc gggacacgca cgaccctcgc cctgccaaca ggctcaggcc gaggtggtgg
    20641 tcaccgcgtc ccgcgcctcc ttgccggtcg ggcctgcctg ccgggcgcag tgggcgcagc
    20701 agtagaaccg gccgtccacc tgcacgccgt ggccgatcac ccggcaactg cagtgctcgc
    20761 agatgggcgc gagccggttg atggcgcatt cgaaggagtc gaacgtgtgc ctgccgccat
    20821 cacgggtgtg gacctcgaac gccaggtcgt agtcgttgcc gcagacctcg caggtcgcca
    20881 tggtggatca cccttccgtc tcggatgcgg gtgtagtgat tcccgcatgg atgccacccg
    20941 aaacccggag tggatcagcg gccggtgaac cgggcctccc gccgttcgac gaaactctgc
    21001 agcccttccc tggcgtcctc gctggccagg atgccgggca gcagctcacg caggtgatcg
    21061 gccgcggccc gctcggactc ggcgcgctgc gcgaggcggg cgttggccag ggtgccctgc
    21121 acgccgagcg gggcctgcgc tgcgatcacc ctggccagct cggtggcgcg ttcgagctgc
    21181 tcgcctgccg ggacgacctc ctggaccagc ccgatgcggt gggcctcggc cgcgccgaac
    21241 tcctccccgg tgagcaggaa gcgcatggcg ttgccccagc cgagctgcgc gggagcacgc
    21301 agggtcgccc cgccgaatgg caggatgccc cggccgatct ccagctgccg gaaccgcacg
    21361 tcctcggccg acaccacgat gtcgctggcc agcgcgagct cgatggacag ggtgaaggcg
    21421 atgccctgca cggcgaggac caccggctta ccgaccggct cgttccacaa cccgaacggg
    21481 tcatgcctgc cgtccccgga gagcgcgcca gggccgtgct cggccacggc gggcgagacg
    21541 tcggcgagat ccagtccggc gcagaagtgg tcgccgtgcc cgaagagcac gccggcccgc
    21601 agctcggggt cgtcggcaag ctggtcgtag gccgcgctga ccgcggagat cgtcgccagg
    21661 tcccaagcat tgcgtttctc cggccggttc accccgatga gcagcacatg accgtcccgc
    21721 tgcacggtga ctcgctcaga catccatcct cctactggtc ggtaactacc cgacacagta
    21781 ggcggttccc tgctcagggc cgcaacacca ccttgccggt ggtgcgccgg ttctccagcg
    21841 cggtgtgcgc cgtggacgcc tcggccagcg cgaatggctc gtgcaccagc ggggtcagcc
    21901 tgccatcggc cagcgcggcc agcgactcct cctccagccc gcgcaggccg ccgggcctgc
    21961 gctgccacag ccggggaccc agtgcgaccg aggcggtcag cccgcgggag aacaggtcgg
    22021 tggtgtcgag ccgcaccgga tcctgcccac gggcccagcc gaacatgatg atccggccgc
    22081 cggcgccgag caggtcgaag gccgcccggc cggcgcgccc gcccacgccg tccagcaccg
    22141 cggtgacctc ccgcccgtcc agccattccc gcacccgctc cggccagtcc tcctcggtgt
    22201 agtcggcgga gaaggtcgcc ccgagctccc cgaccctggc gaccttctcc gcacccccag
    22261 ccagcccgac cacggtggcg ccgatattgc gcgcctcctg caccagcagg ttgccgatcc
    22321 cgcccgcggc ggcgggcacc aggacgacat cctccgcggt cagctgcgcc acatgcagga
    22381 tgccgatggt ggtgcggccg gtgccgatca tcgccacggc cgcctcctcg ctcaccccgt
    22441 ccggtaacgc atgcagcgaa ccggccttgg cgaggacccg ctcggcgtaa cctccgttcg
    22501 cctgaccgag atgcaccacg acccgcctgc cgagccagtc cccttccacc cgctcgccga
    22561 tctcgtccac caccccggcc acttcccggc ccggggtcat cggcagctcc gggggcgcga
    22621 acggaccacc ggacccgccc tgccgg
//
