LOCUS       NZ_CP076538            22244 bp    DNA     circular CON 16-DEC-2024
DEFINITION  Amycolatopsis aidingensis strain YIM 96748 chromosome, complete
            genome.
ACCESSION   NZ_CP076538
VERSION     NZ_CP076538.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis aidingensis
  ORGANISM  Amycolatopsis aidingensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     YIM 96748 draft genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2021) Yunnan University, Yunnan Institute of
            Microbiology, 121 Street, Yunnan 650000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdevono v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018885265.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 14:59:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,118
            CDSs (total)                      :: 7,060
            Genes (coding)                    :: 6,941
            CDSs (with protein)               :: 6,941
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 119
            CDSs (without protein)            :: 119
            Pseudo Genes (ambiguous residues) :: 0 of 119
            Pseudo Genes (frameshifted)       :: 44 of 119
            Pseudo Genes (incomplete)         :: 87 of 119
            Pseudo Genes (internal stop)      :: 2 of 119
            Pseudo Genes (multiple problems)  :: 13 of 119
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:56:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4873403
            Orig. end                         :: 4895647
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP076538.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22244
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="25"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22244
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22244
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12244](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12244)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(257..1246)
                     /locus_tag="KOI47_RS35805"
     CDS             complement(257..1246)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667713.1"
                     /locus_tag="KOI47_RS35805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GbsR/MarR family transcriptional regulator"
                     /protein_id="WP_269756647.1"
                     /transl_table=11
                     /translation="MPGGRLTHEHRRRIASGLAEGLGYAQIARQLGRPTSTIAREVARN
                     GGSESYQADRAQHATGERARRRKPAPRPEQPLPDTRGRDPEVVREFVDRFAGLLAQAGL
                     PRMAARVLACLVSTDAGALTAAELVRRLRVSPASVSKAVGYLEGLEIIRRERDSPRRRE
                     RYLVDDDAWLRSWVTSARTNAMWAEAAQQGVTVFGPATPAGNRLAAMGRFFARLSEDMS
                     GGPSLAAGQDALTVLAALLHAGTPLTVDQLETALGWPADRVTDALRDAERHPEATDPIV
                     LGRTDSGACTIGARSDRLSAAQRTALDRVHATIRGLGLPTRGGRQRAE"
     gene            1447..2382
                     /locus_tag="KOI47_RS22240"
     CDS             1447..2382
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681210.1"
                     /locus_tag="KOI47_RS22240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_232376168.1"
                     /transl_table=11
                     /translation="MSRRDPDTRAVLDVRELRMRYGRTDVLRDVTFRAQHGEVLALLGP
                     NGAGKTTTIEILEGFRMRSAGQVEVLGTDPARADERWRARLGIVLQSWRDHGKWRVREL
                     LAHLGSYYRCYSTALVSRPWDVDELIATVGLTEHADKKIKTLSGGQRRRLDVAIGLVGR
                     PEVLFLDEPTAGFDPRARHEFHNLVHGLARRQETTILLTTHDLDEAEKLADRILVLTGG
                     RILAQGTAAELAQRISGVDQVCWTRCGRRFVQETAESTRFAFELFQRYGEQVVDLEIRR
                     SSLEDTYLSLVRQAESGHGGARPDEWEVAR"
     gene            2379..3227
                     /locus_tag="KOI47_RS22245"
     CDS             2379..3227
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228829.1"
                     /locus_tag="KOI47_RS22245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_216206783.1"
                     /transl_table=11
                     /translation="MNPTVTALRAGWSRGLIELRQSFTNGADLWNHFFWPGLMLIVVYL
                     LRDVSFGQSGFALGTLILPSILGMNAAMAMVTMSQLLAIEREDGTLLRAKATPNGMLGY
                     LTGKIVSVSGNVLIDLAILLVPGLVIVSGLAVGSLGTWLTLGWVLALALVATLPIGAVL
                     GSLGTSARSQGLVTLPILGMIGISGVFYPIAAMPEWVQWLAQIFPIYWLGLGMRSALLP
                     DVAVTVELGESWRHLETACVLGAWAALGLILAPILLRRMARRESGSNVAQRRERALQRI
                     G"
     misc_feature    3150..3152
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3275..3775
                     /locus_tag="KOI47_RS22250"
     CDS             3275..3775
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672231.1"
                     /locus_tag="KOI47_RS22250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_216206785.1"
                     /transl_table=11
                     /translation="MATDDDSVTLRPATSEDASAIADIWQAGWRDGHLGHVPDALTAVR
                     TAESFAIRAEQRVGDTVVGTVGGAVAGFVMVVDDEVEQVYVAAGHRGSGVAAVLLAEAE
                     RLVATNGHEYAWLAVVAGNARARRFYERNGWTDEGRFDYPAATEAGAIPVPAHRYLKRT
                     RSA"
     gene            3827..5077
                     /locus_tag="KOI47_RS22255"
     CDS             3827..5077
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014741.5"
                     /locus_tag="KOI47_RS22255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HNH endonuclease signature motif containing
                     protein"
                     /protein_id="WP_216206789.1"
                     /transl_table=11
                     /translation="MTRTFGIDTSRMSEEELLTALGDLEQQRRALYARELAVLAELDGR
                     DTANQQGYRDLPTLTREILRLNPYDARQRVAHARAVVRRYGPGGIPLEPDLPEVGAAAA
                     EGVIGPEHIETIRATITRFPQPVSLPDREHAEALLTKAAREYEPHTITTLGREILARLD
                     QDGTPPTEDELARPERALDWRETRGGRLRGTFDLDAETAALLTGLIEPRAKPSGTKEEP
                     DRRSKFQRQGDAFADVLRVAAGCPEEGPTEAGEPFTVMVSITLEDLKHGTGYGLLHGQE
                     SYSAAQIRRMACDAYVVSAVLGSKGEILDIGQRTRAVPLAIRRALILRDRGCAFPGCRK
                     KPKQCDAHHVIYWANGGPTALHNLTLLCWYHHNLIHHTDWQVRMRNGLPEFIPPAFLDP
                     ERRPRRNLLHRQGKGAE"
     gene            complement(5106..5543)
                     /locus_tag="KOI47_RS22260"
     CDS             complement(5106..5543)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229817.1"
                     /locus_tag="KOI47_RS22260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_216206792.1"
                     /transl_table=11
                     /translation="MDLAELLDRTGLDVLDHLERQATIPVLDGPQAQGDLIVLPLSMLT
                     PVDLLIGARWRPVPLEGVELVRGAAGNNPHTLVAESGACQWTTAVRDPLGLGIVAFENT
                     APAYLVHPEHGGSGVAAGCWLVRRQQERGVGARKGNMLIAD"
     gene            complement(5569..6765)
                     /locus_tag="KOI47_RS22265"
     CDS             complement(5569..6765)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229816.1"
                     /locus_tag="KOI47_RS22265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6745 domain-containing protein"
                     /protein_id="WP_216206794.1"
                     /transl_table=11
                     /translation="MSGLRGRKARSRAVPADVAAKIELWWRAVALRAEWQRHILRTGPA
                     DRKATEEAIAGLYALLGEPRPRFVWVDSPAAAMRLLPPPPTLRLGGPWPVESRIATLAS
                     TLRRRLDWYTGGHREPWMNTAGPPADPLSALRSGTTIQSLVDEGIGDVLRRVARESVAG
                     VLRAELPERLGLVWYGQHEADLVARYEASRLLHGNPLPAADAEQLELWATIARSGGWWW
                     PRGDRCVIAERPAAVHTEPLPGTAYDEVRLHHADGPSVVFPDGWAVHAWHGTWVPSWVI
                     EAPTVRRITSERNAEVRRCAIERIGWQAFIDRAGLTLIGRTADPGNPGCDLSLYDLPRH
                     RGVTPARLLHVVNGSVERDGTRRQYGLHVPPWFDDPIDAAGWSYGLSGAQYSLLRRRT"
     gene            complement(6857..7426)
                     /locus_tag="KOI47_RS22270"
     CDS             complement(6857..7426)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042779.3"
                     /locus_tag="KOI47_RS22270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TOPRIM nucleotidyl transferase/hydrolase
                     domain-containing protein"
                     /protein_id="WP_216206797.1"
                     /transl_table=11
                     /translation="MNPGEGDRAAILVEGPSDRRAIETLARLRGRDLRAEGVVVVPMGG
                     VTNIGHFLERLGPRGRGLRLAGMCDAAEEHHVRRALERTGYGAALSRAEMARLGFHVCV
                     VDLEDELIRALGTDRVERTLAAEGELASFRVLQKQPAQRDRELGRQLRRFLGCRSGRKA
                     RYAGLLVEALDPARPPEPLERVLAQV"
     misc_feature    complement(6923..6925)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7498..8040)
                     /locus_tag="KOI47_RS22275"
     CDS             complement(7498..8040)
                     /GO_component="GO:0042597 - periplasmic space [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016176.5"
                     /locus_tag="KOI47_RS22275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YceI family protein"
                     /protein_id="WP_232376169.1"
                     /transl_table=11
                     /translation="MDERTYLMNDPKIEIPAVGDYRIDPERSAVSFTTRHIFGLAAVRG
                     TFRLREGQIHVADPVSGSTVRASIAAGSFDTGLSARDVTVRSAQYLDTEKHPDITFAAD
                     RAERVEGRWVLPGSLTVLGRAREIQVPVEEVRQEGSLLRARASARVDRYEFGITAMKGM
                     TGRYLDLRLEIIAGRAG"
     gene            8193..9332
                     /locus_tag="KOI47_RS22280"
     CDS             8193..9332
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420539.1"
                     /locus_tag="KOI47_RS22280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_232376170.1"
                     /transl_table=11
                     /translation="MYRNPVCRRWEPLVLAAAGLLTAATAYGEYAGGSRGWALGADLAA
                     GLVACGLLPLVLRRPVHGALALAALAALVPTATPVSTIGTLQVARSRPFPVAAAVAGAG
                     ACAHVLRGLWQPLGGLSFGWWLVLVLLGHAALLGWGALAAARGALIDTLQERARRAETE
                     QGRRVAEARAAERARIAREMHDVLAHRLSLLATYAGALEYRPDHPPERLAHAAGVVRTG
                     VHQALDELREVITVLREDTGGDGTGRPVPGISDLPELVEESRATGTPVELRDGLADPAA
                     LPGPTGRTAYRILQEALTNARKHAPGLPVSITLDGSAGDQLLIEVSNPLPGAAGPPAVP
                     GTGTGLVGLTERVRLAGGQLDQLARSGEFRLHARLPWPA"
     gene            9329..9982
                     /locus_tag="KOI47_RS22285"
     CDS             9329..9982
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420538.1"
                     /locus_tag="KOI47_RS22285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_216206799.1"
                     /transl_table=11
                     /translation="MNDIVRVLVVDDDPLVRGGLTLMLDGAPGIAVAGEAGDGDQVPAA
                     LDAHATDVVLMDIRMPRLNGIIATRRTRARANPPEVIVLTTFDTDENVLLALRAGASGF
                     LLKDSPPTEIAGAIRTVAAGDPILSPGITRRLMDRAATEAGSYQRARSALDTLSAREHE
                     VAVAVGRGGSNAEIATELHLSVATVKAHITRIHTKLDLGNRTQIALLVHDAGLC"
     gene            complement(10001..12244)
                     /locus_tag="KOI47_RS22290"
     CDS             complement(10001..12244)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667245.1"
                     /locus_tag="KOI47_RS22290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_216206803.1"
                     /sec_met_domain="T1TS (E-value: 1.3e-83, bitscore: 280.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQAFALPEFYVPYPARINPHLERAREHSSDWARRMGMLDAPKPGG
                     GVVWDQAALDQMDYALMCAYTHPDCDGPTLDLITDWYVWVFFFDDDFLEQFKYSRDRAG
                     AKAYLDRLEQFMTLEGETPPEPENPAEAGLKDLWERTVPAMSSEWRQRFITSTHNLMVE
                     SMWELDNIDRGRIANPIEYVQMRRRVGGAPWSANLVEYAVGAEVPALLAETRPMQVLAD
                     TFADAVHLRNDLFSYQREVQEEGENSNAVLVFERFFDCSTQEAAELVNDLLTSRLQQFE
                     STALADVPALCADRAAPCQDQAAIAAYTKGLQDWQSGGHEWHVRSSRYMNEGADSAGQA
                     GPLGGPTGLGTSAGRIAATLRIGAGRRAEQHAHVPFQPVGPLPLPELYMPFPIRTSPHL
                     DAARSYAVDWARRMGMLDSVPGVEHGGVWDERRFIGLDLPHCAAMIHADATLEELYLSS
                     DWLAWGTYGDDYYPVVFGHRRDLAGARASNARLAEFMPLDMGPTPEPLNPLERGLADLW
                     QRTAEPMPQENRQRFRLAVEEMLESWLWELSNQAQNRVPDPIDYVEMRRRTFGSEMTKS
                     LARLSYADRVPAELYRTRTMHELDTAAQDYACFANDLFSYQKEIEYEGEVHNLVLVVEN
                     FLNVDRLRARDIVAELMAARMLQFEHIIANELPALFEEFELDDEAREIVQRHADELKEW
                     MSGILEWHRKCVRYTEPELKRNRFPGAPAEFSFLPTGLGTSAARVGAGSGGPR"
     misc_feature    complement(12309..12327)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.26"
                     /tool="antismash"
     gene            complement(12438..13052)
                     /locus_tag="KOI47_RS22295"
     CDS             complement(12438..13052)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333876.1"
                     /locus_tag="KOI47_RS22295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_216206805.1"
                     /transl_table=11
                     /translation="MDPRKARTIEALLRAGEELFRRRSAEEVTVEELAGRAGVAVGSVY
                     NHFGSKAGLHAAVLERAIRLDRDYMDRAYRRAGSPIARIYAAAEEYLAFYLAHPDYFRM
                     LAFPNAPGQYPAGRELTERLARAVREQNERLVRALREGIEAGELRPVDPEETATVLWSA
                     WNGIISLGWRPDALHRDEAGLRRLLAAATEMVANGLLPRPD"
     misc_feature    complement(13057..13073)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.96"
                     /tool="antismash"
     misc_feature    13066..13079
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.82"
                     /tool="antismash"
     misc_feature    complement(13116..13129)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.61"
                     /tool="antismash"
     gene            13150..14031
                     /locus_tag="KOI47_RS22300"
     CDS             13150..14031
                     /NRPS_PKS="Domain: Abhydrolase_1 (32-261). E-value:
                     5.4e-24. Score: 77.1. Matches aSDomain:
                     nrpspksdomains_KOI47_RS22300_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333875.1"
                     /locus_tag="KOI47_RS22300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_216206809.1"
                     /sec_met_domain="PF00561 (E-value: 4e-18, bitscore: 64.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.1e-15, bitscore:
                     55.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEPCGRDPRLGQAKQVRLPAGTVRYHEIGSGPVLVFVHGYLVNA
                     DLWRKLVPLLADRFRCITPDWPLGSHTSPMRREADLSPPGIARLIADLLEALDLREVTL
                     VGNDSGGAYSQLVAAHHPERLGGLVLNSCETPWCSWPPGPGGFGLLKLAARHPAPHRIL
                     YQPLRLRLSWRLPNTYGSLAKYPIEARVMRGYVRPVLDSTSVRRDGRKAIGAVSARFVQ
                     EAAQRLRSSFPGPVLCLWAAEDRVFPLTHGQSYAERIGATFRTVAGSFTYTAEDQPGRT
                     AEALRGWLEQPA"
     aSDomain        13246..13932
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KOI47_RS22300_Abhydrolase_1.1"
                     /evalue="5.40E-24"
                     /label="KOI47_RS22300_Abhydrolase_1.1"
                     /locus_tag="KOI47_RS22300"
                     /protein_end="261"
                     /protein_start="32"
                     /score="77.1"
                     /tool="antismash"
                     /translation="PVLVFVHGYLVNADLWRKLVPLLADRFRCITPDWPLGSHTSPMRR
                     EADLSPPGIARLIADLLEALDLREVTLVGNDSGGAYSQLVAAHHPERLGGLVLNSCETP
                     WCSWPPGPGGFGLLKLAARHPAPHRILYQPLRLRLSWRLPNTYGSLAKYPIEARVMRGY
                     VRPVLDSTSVRRDGRKAIGAVSARFVQEAAQRLRSSFPGPVLCLWAAEDRVFPLTHGQS
                     YAERIGA"
     misc_feature    13648..13650
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14112..14909
                     /locus_tag="KOI47_RS22305"
     CDS             14112..14909
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021631.5"
                     /locus_tag="KOI47_RS22305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DNA polymerase beta superfamily protein"
                     /protein_id="WP_216206812.1"
                     /transl_table=11
                     /translation="MTATARHTEHGNRDIALDGEILRTVVGSGVHGIAIEGTDDHDEMG
                     VFVEPAEHVLGMRKPVEHYVFRTQPEGVRSGPGDTDLVVYSLRKYLRLAMKGNPTMLLP
                     LYAPTEAVVALRPLGEELRALAPAVLSRQAGHRFLGYLDAQHRRLLAHGQQGRMPKRPE
                     LIARYGYDVKYASHALRLAYQGLEVVREARLTLPMPEREREHVLRVKRGELPLEEVLRD
                     ILEVRTAVTGLLDAGRTPLAAGPDLDRIAGWATDAHRRHWSWN"
     gene            complement(14926..15657)
                     /locus_tag="KOI47_RS22310"
     CDS             complement(14926..15657)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024583.5"
                     /locus_tag="KOI47_RS22310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GAF and ANTAR domain-containing protein"
                     /protein_id="WP_216206815.1"
                     /transl_table=11
                     /translation="MKGDRGVYRAFVEVADTVRGDFDLIEFLDTVVHRSAELLDIADCG
                     LLLEDESGEPSLIAASTERVRQLGLLQLRKGTGPCLDCLHSGRRVQHTDLAAGTAGWPE
                     FTPEALASGFLTVYAVPLRHRQHTIGAMNAFSPAPLSGDSLDLWQSLADVATIGLVHER
                     AVRHGAAVNRQLQEALNSRVLIEQAKGALAERMSIPVDDAFAVLRGNARRNRRTVRELA
                     VRVLDGRALPDGDPPAGPGGP"
     gene            complement(15685..15921)
                     /locus_tag="KOI47_RS22315"
     CDS             complement(15685..15921)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS22315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216206819.1"
                     /transl_table=11
                     /translation="MVEDEGVDSACRPIAVDLDMLLLPGNVHEAAGMVSVQLGLTIEEA
                     IEVLRVRARRYGLDMADLGERVITGEIRFAPRR"
     gene            complement(16065..17072)
                     /locus_tag="KOI47_RS22320"
     CDS             complement(16065..17072)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS22320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216206822.1"
                     /transl_table=11
                     /translation="MGVVNSATELLVRPSARVGVSDVRRLELLTRTLRVADHRYGGRAC
                     RADVLAALSTGRRMLASASTQRVRAELYPAVADQHNLAGWVSFDSGLTATALGHFNSAL
                     TLAAAERNYGLLADVRYRMGHVYLHQGTAHEAIRQFGLGQHAAKQDGDPGVTQAVLLVH
                     QARALAQLGDSRQALSMLGRAVAHFSQADTETAPPWAELVDSAEIAAMIGSAHTELARY
                     VDVSFTRSAIVTLSSALTGYGNSRHRSRSLAEISLAINRILAGDLEQGLATALRALELS
                     ATLRSTRVRNRFVVLERELGKHLGSVEAQRVAGRIAEFVARQSVPDRQGRGRRK"
     misc_feature    complement(17043..17045)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(17057..17072)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.83"
                     /tool="antismash"
     misc_feature    17178..17189
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.47"
                     /tool="antismash"
     gene            17286..17975
                     /locus_tag="KOI47_RS22325"
     CDS             17286..17975
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028100.1"
                     /locus_tag="KOI47_RS22325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_232376171.1"
                     /transl_table=11
                     /translation="MSTSGETPVTEYRQPRFEAPPGSTELLLIRHGESAPAVDGVPFPV
                     LGAHSDPDLAPEGRQQAERVGERLAKEHIDAIYVTTLRRTAQTAEPLAGRLGLTPAVEA
                     DLREVLLGEWEGGLLRKRVAENHPTAQRLWAEQRWDVIPGAEPAPEFAARVRGAVERLV
                     AAHPDERLAVFTHGGVIAAVLAAATGSEPFAFIGADNASISGLVVHGSRWILRRFNDIA
                     HLPPAGR"
     gene            complement(17998..18960)
                     /locus_tag="KOI47_RS22330"
     CDS             complement(17998..18960)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019813228.1"
                     /locus_tag="KOI47_RS22330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="threonine/serine dehydratase"
                     /protein_id="WP_216206825.1"
                     /sec_met_domain="PALP (E-value: 1.2e-68, bitscore: 230.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQANLADVDIDPARIAEAAKVIDPLFLDTPQFVDEQLCAALGRRV
                     LVKVETLNPIRSFKARGAQWLLAGYPAGAEVVCASSGNFGQAVAYAAGRRGMTAEVFTP
                     ANGNQGKLARMRSLGAVVHQVEGNPREAAREYVRERPGRIFIEDGREPAVAEGAGTIGM
                     ELLAAGGIDTVVVPVGDGSLITGVARWIKEHAPRMTVVGACAAGAPGMARSFGSGQPEA
                     AEVDTFADGINVRAPIPESLTRMRALVDEVVLVEDEAMLAAIRTAAQTLGLLLEPAGAA
                     SLAAIAEHDLPGGTIAAVLSGANLNPDLFERVLGGAGRS"
     gene            complement(19056..20003)
                     /locus_tag="KOI47_RS22335"
     CDS             complement(19056..20003)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783035.1"
                     /locus_tag="KOI47_RS22335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="threonine/serine dehydratase"
                     /protein_id="WP_216206828.1"
                     /sec_met_domain="PALP (E-value: 2.2e-65, bitscore: 219.6,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELVTIDEVRAAASRIEGRTLRTPLLEPEPLSAEFASRVLVKPEN
                     LQHTGSFKVRGALNTLLDWRDRGSLPEGVVTFSAGNHAAAVALAGEQLGVRTIVAMPTE
                     PIASKVENVRRYGGEIVPTDDLAGTCAALAAEHGYPALYPFDMPEVIAGQGTVGLEICA
                     DGPEPGLVLVPVGGGGLLSGVAVAVRALAPRARIVGVEPETSNAMSLAVRAGEIVPVPD
                     PAATIADGLTAPFAGRHTLAHVLALVDEVVEVPDRAIGEAWRGMVESTKLLVEPSAALG
                     LAALRTGAVRPRPEGATVLVLSGGNTDLHRLAAQ"
     gene            20090..20800
                     /locus_tag="KOI47_RS22340"
     CDS             20090..20800
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645412.1"
                     /locus_tag="KOI47_RS22340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_216206830.1"
                     /transl_table=11
                     /translation="MYREAPPPARLRQAVRCLWWSAGEGTKLIVPDGCLDLIVAADRVF
                     VAGPDTRPWDSTATGTLHGVRFRPGYAPRVLRVAADELRDQRVTLPELWGRRGAGIADL
                     LLTRPAALGQIVADNLTDWPDPGLDLLLARLTTGVPRVSAALDDLGTGERQLRRRFTQA
                     VGYGPATYLRVARLQRARAAAPAAASLSALALTAGYADQAHLNRDCRELTGRTPREFFG
                     TGDRSVQDRPRHGG"
     gene            20811..21740
                     /locus_tag="KOI47_RS22345"
     CDS             20811..21740
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS22345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216206833.1"
                     /transl_table=11
                     /translation="MSTNTTVDTEAARRGRTFLATHARVLERRLAELHLDGGGPAAACA
                     VLDALAAHRNPDGGLGHALEPDVRAPASQPLAVDFGLEVLEQVLDSAAGADELVRDRSR
                     AFAEDLLPFLASVTTADGGLPIVLPSIATHPRAEHWGDGGFPAGLNPTAGIVARLRRAG
                     VTGDSWLSTAEAFCLQRIEALTAGQPCDAHTALNVLRFLARCPDRDWAERQRAVVTGWF
                     GRMPLLHLHPGAGYGLTPLDFAPGPEDPLRAVFPADAVRAHLDALAAAQAEDGGWPLSW
                     RPPGPAAELEWRGVCTLNALRILAVNPR"
ORIGIN
        1 cggccacggc aaggcacccg atgatccgcg ggtacgggag gtgctcaccg agttggcagg
       61 ccggagtccc gagttcgcac ggctgtgggc ccaccacgac gcccggggca aggcactgga
      121 acacaaacgc ttcgaccatc ccggcgtcgg tccgctgacc ctgagcatgc ataccttcga
      181 cgtccgatcc agtcccggcc aggaactcgt ggtctaccac gccgagccgg attcgcccag
      241 cagtgaggcg ctggcgttac tcggctcgtt ggcggccacc gcgcgtcggg agccctaggc
      301 cccggattgt cgcgtgcacc cggtcgaggg cggtgcgctg ggccgcgctg agccggtcgg
      361 aacgcgcacc gatggtgcag gcgccggaat cggtgcgccc cagcacgatc gggtcggtcg
      421 cctccgggtg ccgctcggca tcccgcaggg cgtcggtgac ccggtccgcg ggccagccga
      481 gcgcggtctc cagctggtcc acggtcagtg gtgtaccggc gtgcagcagc gcggcgagca
      541 cggtcagcgc gtcctggccc gcagccaggc tggggccgcc ggacatgtcc tcgctgaggc
      601 gggcgaagaa ccggcccatg gccgccagcc ggtttccggc cggggtggcc gggccgaaga
      661 ccgtcacccc ctgctgcgcg gcctccgccc acatcgcgtt ggtgcgcgca ctggtcaccc
      721 aactgcggag ccaggcatcg tcgtcgacga ggtagcgctc acggcgccgc ggggaatctc
      781 gttctcgccg gatgatctcc agcccttcca ggtagccgac cgccttggac accgaggcgg
      841 ggctgacccg caaccgccgc accaactcgg cggcggtcag cgcgcccgcg tcggtactga
      901 ccaggcaggc gagcacccgc gccgccatcc gcggcagccc ggcctgggcc agcagccccg
      961 cgaaccggtc cacgaactcg cgtaccacct cggggtcccg gccacgggtg tccgggagcg
     1021 gctgctccgg ccggggcgca ggcttgcgcc gccgggcccg ctccccggtg gcatgctggg
     1081 cccgatccgc ctggtagctc tcggacccac cgttgcgggc cacctccctg gcgatggtag
     1141 aggtcggcct gcccagctgc cgggcgatct gcgcgtaacc cagcccttcg gccagcccgg
     1201 acgcgatacg ccgccggtgc tcgtgagtca gcctgccgcc cggcatccgt gttcgcctcc
     1261 tgatcgacgg gtccggtcca gtgtgcgttc acattcagga cattgcaacg gtaggtgaac
     1321 catacattgc attcactgat tagaccattg caattactgc tgttcaactc gcatgatctg
     1381 cgcttagttc gttgacggaa ttatgaatgc aacgtagcct tcgcagatgt cgaaaggatt
     1441 cgggcaatga gtcgacggga ccccgacacg cgggccgtgc tggacgtacg ggagttgcgc
     1501 atgcgctacg gaaggaccga cgtcctgcgc gatgtgacat tccgagcgca acacggggag
     1561 gttctggctc tgctcggacc gaacggtgcg ggcaagacca ccacgatcga gatcctggag
     1621 ggattccgaa tgcgctcggc cggacaggtc gaggtactcg gcaccgatcc ggcacgggcc
     1681 gacgagcggt ggcgggcccg gctcgggatc gtgttgcagt cctggcggga ccacggcaag
     1741 tggcgggtac gcgaactgct cgcgcatctc ggttcgtact accgctgcta ctccaccgcg
     1801 ctggtctccc ggccgtggga cgtggacgag ctcatcgcga cggtcggcct gaccgagcat
     1861 gcggacaaga agatcaagac gctgtccggt gggcaacggc gcaggctgga cgtggcgatc
     1921 ggtctggtcg gacgccccga ggtgctgttc ctggacgagc caacggcggg attcgacccg
     1981 cgggcccggc acgagttcca caacctggta cacgggctcg cccggcggca ggaaaccacc
     2041 atcctgctca ccacgcatga cctggacgag gccgagaagc tcgccgaccg cattctggtc
     2101 ctgaccggtg gacggattct cgcgcagggt acggcggcgg aactcgccca gcgcatctcc
     2161 ggtgtggacc aagtgtgctg gacccgctgc ggccgccgtt tcgtccagga gaccgccgaa
     2221 tcgaccagat tcgccttcga gctgttccaa cggtacggcg agcaggtcgt cgatctcgag
     2281 attcggcgtt cctcgctgga ggacacttat ctttccctgg tgcggcaggc ggagtccggc
     2341 catggcgggg cgaggccgga cgagtgggag gtggccaggt gaacccaacc gtgacagccc
     2401 tgcgcgcggg ctggtctcgc ggcctgatcg agttgcggca gtccttcacc aatggcgcgg
     2461 acctgtggaa ccatttcttc tggcccgggc tgatgttgat cgtcgtctac ctcttgcggg
     2521 acgtttcctt cgggcagagt ggattcgctc tcggcaccct catcctgccg agcatcctcg
     2581 gcatgaacgc cgcgatggcg atggtcacca tgagccagct gctcgccatc gaacgcgagg
     2641 acggaaccct gttgcgggct aaggcgacgc cgaacgggat gctcggctac ctgaccggaa
     2701 agatcgtctc ggtgtccggc aacgtgctca tcgatctcgc gatcttgctg gttcccggcc
     2761 tggtcatcgt gtccggcctc gcggtcggca gcctgggcac ctggctgacc ttgggctggg
     2821 tactggcgct ggcactggtg gccacgctgc cgatcggcgc ggtgctgggc tcactgggca
     2881 ccagcgcgcg cagccagggg ctggtcaccc tgccgatcct tggcatgatc gggatttccg
     2941 gggtgttcta cccgatcgcc gcgatgccgg aatgggtgca gtggctcgcc cagatattcc
     3001 cgatctactg gctcggtctc ggcatgcgtt cggctctgct gccggacgtc gccgtcaccg
     3061 tcgaactcgg cgagtcttgg cgacacctgg aaaccgcctg cgtgctgggt gcctgggccg
     3121 ccctcggcct gatcctggcg ccgatcctgt tacgccggat ggcacgccgg gaatcgggct
     3181 cgaacgtggc ccagcgccgg gaaagagccc tgcaacgaat cgggtaggcc tcggcacgct
     3241 cctggaaccg tcggcgcgcc gctacgcttt atgaatggca accgacgacg actccgtgac
     3301 gctgcgtccc gccacctccg aggacgcgag cgcgatcgcg gacatctggc aggccggatg
     3361 gcgcgacggc catctcgggc acgttcccga tgcgcttacc gcggtgcgga cggcggagtc
     3421 cttcgcaatc cgggccgagc aacgggtcgg cgacacggtg gtggggaccg tcggcggcgc
     3481 cgtggcgggg ttcgtgatgg tggtcgacga tgaggtggaa caggtgtacg tagctgcggg
     3541 ccaccgcggg agcggtgttg ccgccgtact gctcgccgaa gcggaacgtc tggtcgccac
     3601 caacggccac gagtacgcct ggctcgccgt ggttgccggg aatgccaggg cccgcaggtt
     3661 ctacgaacgc aacggatgga ccgacgaggg gcgtttcgac taccccgccg cgaccgaagc
     3721 cggtgcgatc ccggttccgg cacaccgtta cctgaagcga acacggtccg cgtagatcac
     3781 ccgatcgtgt tcgaacacat gagcgaattc acagtatcct ggggttgtga ccaggacttt
     3841 cggcatcgac acctcccgca tgagcgagga ggaactcctg accgcgctgg gcgacctcga
     3901 acagcagcgg cgggctctgt atgcccggga gctggcggtc ctggccgaac tcgacggccg
     3961 cgacaccgcg aaccagcagg gctaccgcga cctgccgacg ttgacgcggg agatcctgcg
     4021 gctcaacccg tatgacgccc gccagcgcgt ggcccacgcg cgggcggtgg tgcggcgcta
     4081 cggacccggt gggataccgc tggagcccga cctgcccgag gtcggtgccg ccgcggccga
     4141 gggcgtgatc gggccggaac acatcgagac catccgcgcc accatcaccc gcttccccca
     4201 gccggtcagc ctgcccgacc gggaacacgc cgaagcgctg ctgaccaagg ccgcgcggga
     4261 gtacgaaccc cacaccatca ccaccctggg ccgggaaatc ctggcccggc tggaccagga
     4321 cggcacccca cccaccgaag acgaactcgc ccggccggaa cgcgccctgg actggcgcga
     4381 aacccgcggc ggacgactcc gcggcacctt cgacctcgac gccgaaaccg ccgccttgtt
     4441 gaccgggctg atcgaaccga gggcgaaacc ctccggcacg aaagaggagc cggatcggcg
     4501 gagcaagttc cagcgccagg gggacgcgtt cgccgacgtg ctgcgggtgg cggcggggtg
     4561 tccggaggag gggccgaccg aggcggggga acccttcacc gtcatggtgt ccatcaccct
     4621 ggaggatttg aagcacggca cggggtacgg gctgctgcat gggcaggagt cctactccgc
     4681 cgcgcagatc cggcggatgg cctgcgacgc gtatgtcgtg tccgccgtcc tcggcagcaa
     4741 aggcgagatc ctcgacatcg gacaacgcac ccgcgcggta cccctcgcca tccggcgcgc
     4801 actgatcctg cgggatcgcg gatgcgcttt cccgggatgc cggaaaaaac ccaaacaatg
     4861 cgacgcgcat cacgtgattt attgggctaa tgggggacca acagccctgc acaacctcac
     4921 actcctctgt tggtaccacc acaacctcat ccaccacacc gactggcaag tcagaatgcg
     4981 caacggacta cccgagttca tcccacccgc gtttctggac ccggagcgaa gacccaggcg
     5041 caacctcctc caccgccaag gaaagggggc cgagtagatc ttgcgtcaca cggccacata
     5101 ttccattagt cggcgatgag catattgccc ttccgggcac cgacaccacg ttcctgctga
     5161 cggcgcacca gccagcatcc ggccgccact ccgctgccac cgtgctccgg atgcaccagg
     5221 taggccggtg cggtgttctc gaaggccacg atcccgagcc cgagcggatc gcgcaccgcg
     5281 gtggtccact ggcaggcacc tgattcggcg acgagggtgt gcgggttgtt gcccgccgcc
     5341 ccgcggacca gttccacgcc ttccagcggt accgggcgcc agcgcgcccc gatcaggagg
     5401 tctaccggag tgagcatgga cagtgggagg acgatcaggt cgccctgggc ctgggggccg
     5461 tcgagtactg gaatggtggc ctgccgttcc aggtggtcca gcacgtcgag tccggttcgg
     5521 tcgagcagtt cggcaaggtc cattgtgatc acctgtaggt acgaagggtc aggtacggcg
     5581 gcgcagcagg gagtactggg ctccactgag cccataggac cagccggccg cgtcgatcgg
     5641 gtcgtcgaac cagggcggca catgcagccc gtactgacgg cgggtgccgt ctcgctcgac
     5701 cgagccgttc actacgtgca gcaggcgggc cggggtgact ccccggtggc ggggcaggtc
     5761 atagagactc aagtcgcagc cagggttacc ggggtcggcg gtccttccga tgagcgtcag
     5821 gcccgcccgg tcgatgaagg cctgccagcc gatgcgctcg atcgcgcagc ggcgcacctc
     5881 ggcgttacgt tccgaggtga tccgccgcac ggtcggcgcc tcgatcaccc aggacggcac
     5941 ccaggtgccg tgccaggcat gtacggccca gccgtccggg aagaccacgg atgggccatc
     6001 ggcgtggtgc aaccgcacct cgtcgtaggc ggtgccgggc agcggttcgg tgtggaccgc
     6061 cgccgggcgt tcggcgatga cacacctgtc cccgcgtggc caccaccagc cgccggaacg
     6121 cgcgatggtg gcccacagct ccagttgctc agcatccgcc gcaggcagcg gattgccgtg
     6181 caggaggcgg ctcgcctcgt accgcgccac caagtcggct tcatgctggc cgtaccagac
     6241 cagaccgagc cgctcgggca gctctgcccg gagcactccg gccaccgatt ccctggctac
     6301 ccgccgcagt acgtcgccga ttccttcgtc cacaagagac tgaatggtgg taccggaacg
     6361 cagggcggac aacggatcgg cgggcggacc ggcggtgttc atccacggtt ccctgtggcc
     6421 tccggtgtac cagtccaacc gtctgcgcag agtggacgcc agggtcgcga tccggctttc
     6481 caccggccac ggaccgccca gccggagggt gggcggcggc gggagcaatc gcatggccgc
     6541 ggcgggcgaa tccacccata cgaacctcgg gcgaggctcg ccgagcaacg cgtacaggcc
     6601 cgctatggcc tcctcggtcg ccttccggtc ggccggtccg gtacgaagaa tgtggcgctg
     6661 ccactcggcc cgcagtgcga ccgcacgcca ccagagctcg attttcgcgg caacatccgc
     6721 cgggacggca cgagagcggg cctttcgccc gcgcagcccg ctcaacgcgg cagggcggat
     6781 ccgccctttc gatcagacat ggtgccgatc atggcagccg cgaacctcgc ccgcaaccat
     6841 cgctcggtgc gccggctcag acctgggcga gcacacgctc cagcggttcg ggcggccgcg
     6901 ccgggtccag tgcctccacg agtaaccccg cataccgggc cttccggccg gaacggcaac
     6961 cgaggaaccg gcgcagttgc ctgccgagct cacgatcacg ctgggcgggc tgcttctgca
     7021 gcacgcggaa ggaagccagc tcgccctccg ccgcgagcgt gcgctcgacc cgatccgttc
     7081 ccagcgcgcg aatcagctcg tcctccagat ccaccacgca gacgtggaag ccgagcctcg
     7141 ccatctccgc cctggacagt gcggcgccgt atccggtgcg ttccagtgca cgccggacgt
     7201 ggtgttcttc ggcggcgtcg cacatcccgg ccagccgcag gccacgtccc cgtgggccga
     7261 gccgttccag gaagtgaccg atgttggtca caccgcccat cggcacgacc accaccccct
     7321 cagcccgcag gtccctgccg cgcaaccggg ccagggtctc gatcgcgcgg cggtcactcg
     7381 ggccctcgac caggatggcg gcccggtcac cttcgccggg gttcaccggt cctcccgccc
     7441 atggccgttc atgaccactg gctatcacaa ccggcgccgg acggcctccg atttagctca
     7501 gccagcccgc ccggcgataa tttccagccg caggtccagg tagcgcccgg tcatcccctt
     7561 catcgcggtg atgccgaact cgtagcgatc caccctggcc gaggcccgcg cgcgcagcaa
     7621 cgacccttcc tggcgtacct cctccaccgg cacctggatc tcgcgggcgc ggcccagcac
     7681 ggtcagcgac ccgggcagca cccagcgtcc ttccacccgc tccgcccggt ccgcggcgaa
     7741 ggtgatgtcc ggatgtttct cggtgtccag gtactgggcc gaacgcaccg tgacatcccg
     7801 cgcggacagc ccggtgtcga agctgcccgc agcgatgctc gcccgcacgg tggacccgga
     7861 caccgggtcg gcgacgtgga tctgcccttc gcggagccgg aaggtgcccc gcaccgcggc
     7921 gaggccgaat atatgccggg tggtgaacga gaccgcggag cgctccgggt cgatccggta
     7981 gtcacccacg gcgggtatct cgatcttcgg gtcgttcatg aggtacgtcc tttcgtccat
     8041 gcggtcctcc cgcgatccga taccgccagc atcgcggacc gcgcccgggg gcgcgtcgat
     8101 cgcacggcca ccgccgcacc gaccagggtg gcgcccgggt tcgactttgg tcgctgtccg
     8161 cacccaccgg gccgcccgta ggctcgcctg ccgtgtacag gaatccggtc tgccgacggt
     8221 gggaaccgct ggtgctcgcc gcggcgggcc tgctcaccgc ggcgaccgcg tacggcgagt
     8281 acgccggggg cagccgtggc tgggcgctcg gcgccgacct cgccgccggg ttggtggcct
     8341 gcgggttgct gccgctggtg ctgcgcaggc cggtccacgg cgcgctcgcg ctggcggcgc
     8401 tggccgcact ggtgccgacc gcgacacccg tctccaccat cggcaccctt caggtcgccc
     8461 gcagccgacc gttcccggtg gcggcggcgg tggccggggc cggggcctgc gcgcatgtcc
     8521 tgcgtggcct gtggcagccg ctgggcgggc tgtcctttgg ctggtggctg gtgctggtgc
     8581 tgctcgggca cgccgccctg ctcggctggg gcgcgctggc cgcggcccgc ggggcgctga
     8641 tcgacacgct gcaggaacgt gcccggcggg ccgagaccga gcagggccgc cgggttgccg
     8701 aggccagggc ggcggaacgg gcacggatcg caagggaaat gcacgatgtg ctcgcccacc
     8761 ggctgtccct gctggccact tacgcgggtg cgctggagta ccggccggat catccacccg
     8821 agcggctcgc gcacgccgcc ggggtagtcc gcaccggcgt gcatcaggcc ctggacgagc
     8881 tcagggaggt gatcaccgtg ctgcgcgagg acaccggggg cgacggcacc ggacggccgg
     8941 tgcccggaat atccgatctg cccgagctgg tcgaggagtc cagggccacc ggcaccccgg
     9001 tcgagctgcg ggacggcctc gccgatccgg ccgcgctgcc cggcccgacc gggcgcaccg
     9061 cctaccgcat cctgcaggaa gcgctgacca acgcccgtaa gcacgccccc ggcctgccgg
     9121 tcagcatcac gctggacggc agcgcgggag atcagctgct gatcgaggtg tccaacccgc
     9181 tgcccggcgc cgccggcccg cctgcggtcc ccggcaccgg aaccggactg gtcgggctaa
     9241 ccgagcgggt gcggctggcc ggtgggcaac tcgaccagct ggcaaggtcc ggcgagttcc
     9301 ggctgcacgc ccggctaccg tggccggcat gaacgacatc gtccgcgtac tcgtggtcga
     9361 cgacgatccg ctggtccggg gcgggctgac cctgatgctc gacggagccc ccggcatcgc
     9421 ggtggccggc gaggccgggg acggggacca ggtacccgcg gcgctggacg cgcacgccac
     9481 cgacgtcgtg ctgatggaca tccgcatgcc gcggctgaac gggatcatcg ccacccggcg
     9541 cacccgggcc agggcgaacc cacccgaggt gatcgtgctg accaccttcg acaccgacga
     9601 gaacgtgctg ctcgccctgc gcgcgggcgc gagcggattc ctgctcaagg actccccgcc
     9661 caccgaaatc gccggggcca tccgcaccgt ggcggcgggc gacccgatcc tgtcccccgg
     9721 gatcacccgg cggttgatgg accgggccgc caccgaggcc ggttcctacc agcgggcgcg
     9781 cagcgcgctg gacacgctca gcgccaggga acacgaggtc gcggtcgccg tgggccgggg
     9841 cggcagcaac gccgagatcg ccaccgagct gcacctgagc gtggccacgg tgaaggcgca
     9901 catcacccga atccacacca aactcgacct cggcaaccgg acccagatcg cgctgctggt
     9961 gcacgacgcc gggctgtgct gagcgcgctg tgctgagcgc tcagcggggc ccgccggagc
    10021 ccgcgcccac cctggccgcg gaggtaccga gcccggtcgg caggaagctg aactccgcgg
    10081 gcgcgccggg gaaccggtta cgtttcagct ccggctcggt gtagcgcacg cactttcggt
    10141 gccattccag gatcccggac atccactcct tgagctcgtc ggcatgccgc tggacgatct
    10201 cgcgggcctc gtcgtccagc tcgaactcct cgaacagggc gggcagctcg ttggcgatga
    10261 tgtgctcgaa ctggagcatc cgcgcggcca tcagctccgc cacgatgtcc ctggcccgca
    10321 gccggtccac gttcaggaag ttctccacca ccagcaccag gttgtgcacc tcgccctcgt
    10381 actcgatctc cttctggtag gagaacaggt cgttggcgaa gcaggcatag tcctgcgcgg
    10441 cggtgtccag ctcgtgcatg gtccgcgtcc ggtacagctc ggcgggcacc cggtcggcat
    10501 aggagagccg ggccaggctc ttggtcatct ccgagccgaa cgtcctgcgc cgcatctcca
    10561 cgtagtcgat cgggtccgga acccggttct gggcctgatt ggacagttcc cacaaccagc
    10621 tctccaacat ttcctcgacc gcgaggcgga accgctgccg gttctcctgc ggcatcggct
    10681 cggcggtgcg ctgccacagg tccgcgaggc cacgttccag cgggttcagc ggctccgggg
    10741 ttgggcccat gtccagcggc atgaactcgg caagccgcgc gttgctcgcc cgcgcgcccg
    10801 caaggtcccg gcgatgcccg aacaccaccg ggtagtagtc gtcaccatag gttccccagg
    10861 cgagccagtc cgaggacagg tagagctctt ccagggttgc gtcggcgtgg atcatcgcgg
    10921 cgcagtgcgg aagatcgagg ccgatgaacc ggcgttcgtc ccacaccccg ccgtgctcga
    10981 ccccgggcac ggagtccagc atgcccatcc gccgggccca gtcgaccgcg taactgcggg
    11041 ccgcgtccag atgcgggctg gtacggatgg ggaacggcat gtacagctcg ggcagcggca
    11101 gcgggccgac cggctggaac ggaacatgcg catgctgctc ggcccggcga cccgcaccga
    11161 tgcgcagggt ggcggcgatc cggcctgccg aggtgccgag gccggtcggc ccgccgagtg
    11221 ggcccgcctg gcccgcggag tccgcgccct cgttcatgta ccggctggaa cgcacatgcc
    11281 actcgtgccc gccggactgc cagtcctgca ggcccttggt gtaggcggcg atcgcggcct
    11341 ggtcctggca tggtgccgcg cggtcggcgc acagcgcggg aacatcggcc agcgcggtgc
    11401 tctcgaactg ctgcaggcgc gaggtcagca gatcgttgac cagttcggct gcctcctggg
    11461 tggagcagtc gaagaagcgc tcgaacacca gtaccgcgtt ggagttctcc ccctcctcct
    11521 gtacttctcg ctggtaggag aacaggtcgt tgcgcaggtg cacggcatcg gcgaaggtgt
    11581 cggcgagcac ctgcatcggc cgggtctccg cgagcagcgc gggaacctcg gcgccgacgg
    11641 cgtactccac caggttggcc gaccagggcg ccccgccgac ccggcggcgc atctgcacgt
    11701 actcgatcgg gttcgcgatc cggccccggt cgatgttgtc cagctcccac atcgactcga
    11761 ccatcaggtt gtgcgtgctg gtgatgaaac gctgccgcca ttcggatgac atggcgggaa
    11821 cggtgcgctc ccacagatcc ttcagcccag cctcggcggg gttctccggt tccggcggtg
    11881 tttcaccctc cagggtcatg aactgctcga gccggtcgag ataggccttc gcgccggcgc
    11941 gatcccggga atacttgaac tgttcgagga aatcgtcgtc gaagaagaac acccatacgt
    12001 accagtcggt gatcaggtcc agggtcggcc cgtcacagtc cggatgggtg tacgcgcaca
    12061 tcagggcgta gtccatctgg tcaagcgcgg cctggtccca cacgacgcca ccgccgggct
    12121 tcggcgcgtc cagcattccc attcgtcgcg cccagtccga actgtgctcc ctggcgcgtt
    12181 ccagatgcgg attgatcctc gccggataag gcacgtagaa ctcgggcaat gcaaaagcct
    12241 gcatgggcgc gtactccctc ggccgactgc gatgactgtg tccaacctgg ccccacctgg
    12301 tccagctcgc tgcatgacat tcgcattcgg ccactccgcg ctgcaacgtc cagctgagcg
    12361 ttgttcggca cgttcggatg aatggccgag cgcacgcaca gtagtaccgc gggtgaatcc
    12421 ggatatccgg acgcggctca gtccggccgt ggcagcaggc cgttcgccac catctcggtg
    12481 gccgcggcca gcaaccggcg caacccggcc tcgtcccggt gcagggcgtc cggccgccac
    12541 ccgaggctga tgatcccgtt ccaggccgac cacagcacgg tcgcggtctc ctcagggtcg
    12601 accgggcgca gctccccggc ctcgatcccc tcccgcagcg cgcggaccag gcgctcgttc
    12661 tgctcccgca ccgcgcgggc gagccgttcg gtcaactccc tgcctgccgg gtactgcccg
    12721 ggggcgttcg ggaaggccag catgcggaag tagtccgggt gggcgagata gaacgccagg
    12781 tactcctcgg ccgcggcgta gatccgcgcg atcggtgaac cggcgcggcg gtaggcgcgg
    12841 tccatatagt cccggtcgag ccggatggcc cgctccagca ccgcagcgtg cagccccgcc
    12901 ttggatccga agtggttgta caccgagccc acggcgactc cggcccggcc ggcgagctcc
    12961 tcgaccgtca cctcctcggc ggaccgccgc cggaacaact cctccccggc gcgcagcagc
    13021 gcttcgatgg tgcgggcctt gcggggatcc atcccgatcc tctcttgtaa cgattgcaag
    13081 aagtgtcccg gcctgctagc gtaccggcac ggttcttgta atggttccaa gaactttcgg
    13141 aggccaccca tggcggaacc ctgcgggcgg gacccgcggc tggggcaggc gaaacaggtc
    13201 cggctgcccg cgggaaccgt gcgctaccac gagatcggga gcggcccggt gctcgtgttc
    13261 gtgcacggct acctggtgaa cgccgatctc tggcgcaagc tcgttccgct actggccgac
    13321 cggttccggt gcatcacccc ggactggcca ctcggctcgc acacctcccc catgcgacgc
    13381 gaagccgacc tgtcgccgcc cggcatcgcg cggctgatcg cggacctgct ggaggcattg
    13441 gacctacgcg aggtgaccct ggtcggaaac gactccggcg gtgcctacag ccagctcgtg
    13501 gccgcgcacc acccggaacg gctcggcggg ctcgtgctga actcctgcga gacaccctgg
    13561 tgctcgtggc caccggggcc gggtgggttc gggctgctga aactggccgc gcggcacccg
    13621 gccccgcatc gcatcctcta ccagccgtta cggctgcgcc tcagctggcg gctgcccaac
    13681 acctacggca gcctggcgaa gtacccgatc gaagcgcggg tgatgcgcgg ctacgtacgg
    13741 ccggtgctgg acagcacctc ggtcaggcgc gacggccgca aggcgatcgg cgcggtctcc
    13801 gccaggttcg tccaggaggc ggcccagcgg ctgcggtcat ccttccccgg accggtgctg
    13861 tgcctgtggg ccgcggagga ccgggtcttt ccccttacac acggacagag ttacgccgaa
    13921 cggatcggcg ccaccttccg taccgtcgca ggctcgttca cctacaccgc ggaggatcag
    13981 cccggacgca cggcggaggc attgcgtggt tggctggaac agccagcctg aggtccactg
    14041 tggactaaac tggtcgcacc agccggaaag tccgtaccat cggcgggcac tcgcgtgtca
    14101 ggattcgcgc catgaccgca accgcgaggc acaccgagca cggcaaccgc gatatcgcgc
    14161 tggacggcga gatcctgcgc accgtcgtcg gttccggggt gcacggcatc gccatcgaag
    14221 gcaccgacga ccacgacgag atgggtgtgt tcgtcgagcc tgccgagcat gtcctcggca
    14281 tgcgcaaacc ggtcgagcac tatgtgttcc gcacccagcc ggagggtgtg cgctccggcc
    14341 ctggcgacac cgacctggtg gtgtactcgc tgcgcaagta cctgcgcctc gcgatgaagg
    14401 gcaacccgac gatgttgctg ccgctgtacg cgcccacgga ggcggtggtg gcgctacggc
    14461 cgctcggcga ggagctgcgc gcactcgccc ccgcggtgct gtcccggcag gctgggcacc
    14521 ggttcctcgg ctacctggac gcccagcacc gcaggctgct ggcgcacggg cagcagggca
    14581 ggatgccgaa gcggccggaa ctgatcgccc gctacggcta tgacgtcaag tacgcctcgc
    14641 acgcgctgcg gctggcctac caggggctgg aggtcgtccg ggaggcaagg ctcaccctgc
    14701 cgatgcccga gcgggagcgg gagcacgtgc tgcgggtgaa acgcggcgag ctgccgctcg
    14761 aggaagtact gcgggacatc ctggaggtcc gcacggcggt gaccggactg ctggacgcgg
    14821 gccgcacccc gctggcggcc gggccggacc tggaccggat cgccggatgg gccaccgatg
    14881 ctcaccgcag gcactggtcc tggaactgac ccggccggag gaaagtcagg gcccgcccgg
    14941 gcccgcaggc gggtcgccgt ccgggagagc ccggccgtcc agcacccgga cggccagctc
    15001 ccggacggtg cggcggttcc tgcgggcgtt cccgcgcagc acggcgaacg cgtcgtccac
    15061 cgggatgctc atccgctcgg ccagcgcgcc cttggcctgc tcgatcagca ccctgctgtt
    15121 gagcgcttcc tggagctggc gattgacggc ggcgccgtgc cgcaccgcac gttcgtgcac
    15181 caggccgatg gtggcgacat cggcgagcga ctgccagagg tcgaggctgt caccgctcag
    15241 cggggccggg ctgaacgcgt tcatcgcgcc gatggtgtgc tgccggtgcc gcaggggcac
    15301 ggcgtacacc gtcaggaacc cggaggccag cgcctcgggg gtgaactcgg gccacccggc
    15361 cgttcccgcg gccaggtcgg tgtgctgcac ccggcgcccg ctgtgcaggc agtccaggca
    15421 tgggccggtg cccttgcgca actggagcag cccgagctga cgcacccgtt cggtggaggc
    15481 ggcgatcagg ctcggctcac cggattcgtc ctccagcagc aacccgcagt cggcgatatc
    15541 gagcagctcc gcggatcggt gcaccacggt gtcgagaaac tcgatcaagt cgaaatcacc
    15601 ccgtacggtg tcggccacct cgacaaatgc ccgatagacc ccccggtcgc ctttcatgat
    15661 ctcctcccgt ccaggccgcg tgattcacct ccgcggcgcg aaacggatct ctcccgtgat
    15721 cacccgttcg ccgagatccg ccatatccag cccgtatctc cgtgcgcgaa cacgcaacac
    15781 ctcgatcgct tcctcgatgg tcaacccgag ctgcacgctc accattccgg ccgcctcatg
    15841 cacattaccc gggagcagca acatatcgag atcaacagcg atcggccgac acgcggaatc
    15901 aacaccttcg tcctcgacca tcggacatcc atttctccgg cgagttggcg tcgatcggta
    15961 ccgaggaacg aggccagcag caaagacggc acgatcgacc ggtcattgcc attgtctggc
    16021 tcgcgggaac acgctgccac tcggctggga aacgcggccg cgtttcattt ccggcggcca
    16081 cgcccctgcc ggtccggtac cgactgccgc gccacgaact cggcgatccg cccggcaacc
    16141 cgttgcgcct cgacgctgcc gagatgcttg cccagctccc gttccagcac cacgaaccgg
    16201 ttccgcaccc gagtggagcg cagggtggcg gacagctcca gtgcacgcaa cgcggtcgcg
    16261 agcccctgct ccaggtcccc ggcgaggatc cggttgatcg ccagcgagat ctcggccagc
    16321 gagcggctgc gatgcctgct gttcccgtag ccggtcagtg cggagctcaa ggtgacgatt
    16381 gccgaacggg tgaagctgac atccacgtac cgcgccagct cggtgtgcgc gctgccgatc
    16441 atggccgcga tctccgcgga gtcgaccagt tccgcccacg gcggcgccgt ctcggtgtcg
    16501 gcctgggaga agtgcgccac ggcacgcccc agcatgctca gcgcctgcct gctgtccccg
    16561 agctgggcca gcgcccttgc ctgatgcacg agcagcacgg cctgcgtgac cccgggatcc
    16621 ccgtcctgct tcgcggcgtg ctggccaagc ccgaactggc ggatcgcctc gtgcgcggtg
    16681 ccctgatgca ggtagacatg ccccatccgg tagcgcacgt ccgcgagcaa cccgtagttc
    16741 cgctcggcgg cggccagggt cagcgcgctg ttgaaatgcc cgagcgcggt cgcggtgagg
    16801 ccgctgtcga agctgaccca tccggcgagg ttgtgctgat cggccaccgc cgggtacagc
    16861 tcggcgcgga cccgctgggt gctcgcggag gccagcatgc gtctgcccgt cgacaacgcc
    16921 gccagcacgt cggcccggca ggcccggccg ccatagcgat gatccgccac ccgcaacgtc
    16981 ctggtcagca gttccagcct gcgcacgtcg gagacgccca cccgcgccga tggccgcacc
    17041 agtaactcgg ttgcggagtt gactacaccc atcaaagtca cccgaccaac attcgaacac
    17101 gaaagtcgcc ggggtccggg gcgaaaggac gacaagcagg atcccgcacc catgcggggt
    17161 ttggctaggg tccccgggaa aacgacaacc cttgcgcccc cggtcaccgg gtctcctcgg
    17221 cggcacccgc ccggaccagc ggcgggtccg gccgccggtg ctcttgggtg ggttaccctg
    17281 cggccgtgtc gacctccggc gaaacccccg tgaccgagta ccggcagccc cgcttcgagg
    17341 caccgcccgg atccaccgag ctcctgctga tccggcacgg cgagtccgcg cccgccgtgg
    17401 atggcgtccc gttccccgtg ctcggtgcgc acagcgaccc tgacctcgca ccggaaggca
    17461 ggcagcaggc cgaacgggtg ggtgaacggc tcgccaagga gcacatcgac gccatctacg
    17521 tcaccaccct gcggcggacc gcgcagacgg ccgaaccgct ggccgggcgg ctgggtctca
    17581 cccctgcggt cgaggccgac ctgcgtgagg tgctgctcgg cgagtgggag ggcggcctgc
    17641 tgcgcaagcg ggtcgccgag aaccacccga ccgcccagcg gctgtgggcc gaacagcgct
    17701 gggatgtgat tcccggcgcg gaacccgccc cggagttcgc agccagggtg cgcggagccg
    17761 tcgagcggct cgtcgcggcc catccggacg aacggctcgc ggtgttcacc cacggtggag
    17821 tcatcgccgc ggtcctcgcc gcggcaaccg gctcggagcc gttcgccttc atcggcgcgg
    17881 acaacgcgtc catctccggg ctggtggtgc acggctcgcg gtggatcctg cgccggttca
    17941 acgacatcgc gcatctcccg ccggccggcc gctgaccggg cggccggtcc ggcaacacta
    18001 gctccggccc gcgccgccca gcacccgctc gaacaggtcc ggattgaggt tggccccgct
    18061 cagcaccgcc gcgatggtcc cgccgggcag gtcgtgctcg gcgatagccg cgagcgaggc
    18121 cgctcccgcc ggttcgagca acaaccccag ggtctgtgcc gcggtgcgga tggccgccag
    18181 catcgcctcg tcttcgacca gcacgacctc gtccaccagc gcccgcatcc tggtgagcga
    18241 ctccggaatg ggcgcgcgca cgttgatccc gtcggcgaag gtgtccacct cggcggcctc
    18301 cggctgcccg gaaccgaaac tcctcgccat cccgggcgcg ccggccgcgc aggctccgac
    18361 cacggtcatc cgtggcgcgt gctccttgat ccacctggcc actccggtga tcagcgagcc
    18421 gtccccgacc ggaacgacca ccgtgtcgat accgcctgcc gcgagcagtt ccatgccgat
    18481 ggtgcccgcg ccctctgcca ccgcgggctc gcggccgtcc tcgatgaaga tccggccggg
    18541 ccgttcccgg acgtactccc gcgccgcctc tcgcgggttc ccctcgacct ggtgcaccac
    18601 ggcgccgagg gagcgcatcc tggccagctt gccctggttg ccgttcgccg gcgtgaacac
    18661 ctcggccgtc atacccctgc ggcctgccgc gtaggcgacg gcctggccga agttcccgct
    18721 ggaggcgcac accacctcgg caccggcggg gtagcctgcc agcagccact gcgcgcccct
    18781 tgccttgaag ctgcggatcg ggttcagtgt ctcgaccttc accagcaccc gcctgcccag
    18841 cgcggcgcac agttgctcgt ccacgaactg cggggtgtcc aggaacagcg ggtcgatcac
    18901 cttggcggcc tcggcgatcc gggcgggatc gatatcgacg tcggcgaggt tggcctgcat
    18961 gggattcgtc cttcgcggtc ggctgatcat gacaacctca cgctaggccg gggcgctgta
    19021 ccgacgattg aaagtttccc tccccggacg caaaattatt gcgcggccag cctgtgcagg
    19081 tcggtgttgc cgccggagag caccagaaca gtggctcctt cgggccgcgg ccgcaccgcc
    19141 ccggtgcgca gcgcggccag ccccagcgcc gcggagggct cgacgagcag ctttgtcgac
    19201 tccaccattc cccgccaggc ttcgccaatg gcccggtccg ggacctcgac cacctcgtcc
    19261 accagcgcca gcacatgggc cagcgtgtgc ctgcccgcga acggggcggt caggccgtcc
    19321 gcgatcgtgg cggccggatc gggtaccggc acgatctccc ccgcgcgtac ggcgaggctc
    19381 atcgcgttcg aggtctccgg ttccactccg acgatccgcg cccgcggcgc gagtgcccgc
    19441 accgccacgg ccaccccgct gagcagccca ccaccgccaa ccgggaccag caccaggccg
    19501 ggttccgggc cgtccgcgca gatctccagc cccacggtgc cctgccccgc gatgacctcg
    19561 ggcatgtcga acgggtacag cgccgggtag ccgtgctcgg cggccagcgc ggcgcaggtg
    19621 cccgccaggt cgtcggtggg cacgatctct ccgccgtacc gccgcacgtt ctccactttg
    19681 gacgcgatgg gttcggtcgg catggccacg atcgtgcgca cgccgagttg ctcccccgcc
    19741 agggcgaccg cggcggcgtg gttgcctgcg gagaaggtca ccaccccctc cggcaggctg
    19801 ccccgatcgc gccagtccag cagggtgttc agcgctccac gtaccttgaa gctgccggtg
    19861 tgctgcaggt tctccggctt gaccagtacc cgcgaggcga actccgcgga cagcggctcc
    19921 ggttccagca gcggggtgcg caacgtccgg ccctcgatcc tgctcgcggc ggcccggacc
    19981 tcgtcgatcg tcaccagttc caccgggcca ccctaacgcc gtcgatcact ccggggcgcg
    20041 gatcgaaagc gcccgacgga atgtcggtgg gtgggggcat gatggcggta tgtaccgcga
    20101 ggctccgcca cccgcccggc tgcggcaggc cgtgcgctgc ctgtggtggt ccgcgggcga
    20161 ggggacgaag ctgatcgtgc cggatggctg cctggacctg atcgtcgcgg ccgaccgggt
    20221 gttcgtcgcg ggcccggaca cccggccgtg ggattccaca gccaccggga ccctgcacgg
    20281 cgtccggttc cggccggggt acgcgccgcg ggtgctgcgg gtggccgcgg acgagctgcg
    20341 cgaccagcgg gtgaccctgc ccgagctctg ggggcggcgt ggcgccggga tcgccgacct
    20401 gctgctgacc aggccggccg cgctcggcca gatcgtggcc gacaacctga ccgactggcc
    20461 ggatccgggg ctggacctgc tgctggcccg gctgaccacc ggggtgcccc gggtctcggc
    20521 cgcgctggac gacctcggca cgggcgagcg ccagttgcgc cgccggttca cccaggccgt
    20581 cggctacggc ccggcgacct acctgcgggt ggcccggcta cagcgcgccc gcgccgcggc
    20641 accggccgcc gccagcctga gcgcgctagc gttgacggcg gggtacgccg accaggccca
    20701 tctgaaccgg gactgccggg agctcaccgg ccgtacgcca cgcgagttct tcggcaccgg
    20761 tgaccgttcc gtccaagacc gcccgcgcca cggcggctag cgtccccgcc atgagcacga
    20821 acaccactgt ggacaccgaa gcggccaggc gcggccggac cttcctggcc acccatgcca
    20881 gggtgctgga acggcggctc gccgaactgc acctggacgg cggcggaccg gcggccgcgt
    20941 gcgccgtcct ggacgccctc gcggcccacc gcaacccgga cggcggcctc gggcatgcgc
    21001 tcgaacccga tgtccgcgcc ccggcgagcc agccgctcgc ggtggacttc ggtctcgagg
    21061 tcctggagca ggtgctggac tccgccgcgg gcgcggacga actcgtgcgg gaccggtccc
    21121 gggctttcgc ggaggacctg ttgccgttcc tggcctcggt cacgaccgcg gacggcgggc
    21181 tgccgatcgt gctgccgtcg atcgccaccc acccgcgggc cgagcactgg ggcgacggcg
    21241 ggttccccgc cggactgaac cccacggccg ggatcgtggc gcggctgcgc cgggccgggg
    21301 tgaccggcga ctcctggctc agcacggccg aggccttctg cctgcagcgg atcgaggcgc
    21361 tgaccgcggg acagccatgc gacgcgcata cggcgctgaa cgtgctgcgc ttcctggccc
    21421 gctgcccgga ccgggactgg gccgaacggc aacgggcggt ggtcaccggg tggttcggca
    21481 ggatgccgct gctgcatctc caccccggcg ccggctacgg gctcaccccg ctggacttcg
    21541 ctcccggtcc ggaggatccg ctgcgggcgg tgttccccgc cgatgccgtg cgggcacacc
    21601 tggatgcgct cgccgcggcg caggccgagg acggtggctg gccgttgtcc tggcgtccgc
    21661 cgggccccgc cgccgagctg gaatggcgcg gggtgtgcac cctcaacgcc ctgcggatac
    21721 tggccgtcaa cccccgctga cgaaactcac agcggttggc ttcggtgctg ctgggcggcc
    21781 aggaagtggg cgatgtcggc ggtcgctggg tagagctccc ggtacctggc atagaactcg
    21841 tggtaggtct cggtccgccg cgggtccggc cggaccgtcc tggccagcgg gttccactcg
    21901 gtgatgtccg ggtccatgcc ggtggccacg gcagcaagaa aggcgtcccc gaaggccgcg
    21961 cccacggtct ccgcgggcac ctgctgctcc gccccggtca catcggtgac gatctgggtc
    22021 cagagcccgc cctgcacccc gccgccgacg gcgaccagcc tgcccgcggt gccgccagcc
    22081 gagcccatca cctccaggtt gtgccgcacc ccgtaggcga tgccctccaa cgcggcccgg
    22141 tacagctcgc ccggcccgtg cgcggtggtg agcccggcga gcaccccgcg cgcgtcggcg
    22201 tcgaacagcg gcgtccgctc gcccgcgaag tacggcaaca gcag
//
