LOCUS       NZ_CP076538            25443 bp    DNA     circular CON 16-DEC-2024
DEFINITION  Amycolatopsis aidingensis strain YIM 96748 chromosome, complete
            genome.
ACCESSION   NZ_CP076538
VERSION     NZ_CP076538.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis aidingensis
  ORGANISM  Amycolatopsis aidingensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     YIM 96748 draft genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2021) Yunnan University, Yunnan Institute of
            Microbiology, 121 Street, Yunnan 650000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdevono v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018885265.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 14:59:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,118
            CDSs (total)                      :: 7,060
            Genes (coding)                    :: 6,941
            CDSs (with protein)               :: 6,941
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 119
            CDSs (without protein)            :: 119
            Pseudo Genes (ambiguous residues) :: 0 of 119
            Pseudo Genes (frameshifted)       :: 44 of 119
            Pseudo Genes (incomplete)         :: 87 of 119
            Pseudo Genes (internal stop)      :: 2 of 119
            Pseudo Genes (multiple problems)  :: 13 of 119
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:56:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3736491
            Orig. end                         :: 3761934
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP076538.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25443
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="19"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25443
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25443
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15443](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15443)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(1556..2521)
                     /locus_tag="KOI47_RS17090"
     CDS             complement(1556..2521)
                     /EC_number="2.7.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="carbohydrate kinase family protein"
                     /protein_id="WP_216216921.1"
                     /transl_table=11
                     /translation="MMTTGSVPPGRNPYLVLVAGVVNVRIARGVGTFRKRPASSVVDNG
                     GISVRLSGTGWTLTRTLEQLGTDVAFATYVGTDELGNLVAQQLAQYGHLGATALRCDSQ
                     PRAMVLYDRHGRRANVTDLRSTPDLRYPAHVVQPMLDAGCEAALLTNIGFTRSLLPSVI
                     DRGIPVITDLHLVESADCEYNRDWMRAAHVLACSHERLPTNPESWIRETWRRFGTSITL
                     VGCGPGGVVVGDRRSRRIWRVESCAPRGVRYVSGAGDTFLASFVHHYLRLGDAVAATRN
                     AVLAAGWKVGGHPDEDVGVPRERLARLRATHGLPGATQLR"
     misc_feature    complement(1580..1582)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1919..1921)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2518..2838)
                     /locus_tag="KOI47_RS17095"
     CDS             complement(2518..2838)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216922.1"
                     /transl_table=11
                     /translation="MHDITDDLGPAIAVEPDSNRARLQSADVLLADHPTRESGVRWLGR
                     VFDRYPGCSIAVARHEDGRWWLITIRGDGRVHTCRSGAEPATRAVVERLVEGIYLRAVS
                     RT"
     gene            complement(2831..4057)
                     /locus_tag="KOI47_RS17100"
     CDS             complement(2831..4057)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216923.1"
                     /transl_table=11
                     /translation="MNEPEWSAVPIGIDAKRWTTRGSRRTVLVVVHTVVSGQRLLDIVG
                     LIESDPRVQVVYTRGPDIFHGGVEEFLRSIGALEIPWQQAVREQFDLAIAAAYGGLAQL
                     HAPIMVLPHGAGYAKQTPQGDGNGPTTGRAVYGLGTEHLVRDGRVVPSSIVLSHFAQRE
                     VLARQCPPAADVALVAGDPCYDRLRASLELRDSCRDAIGIQPGQRLVVIASTWGPHSLL
                     ARSMRLISALIDELPRNRYRAAALFHPAVWFGHGIRQVRSWFTDQRAAGLIVAGPDVDW
                     RSVLIAADYVVGDHGSVSTYAAAIGKPVLQASFPSEEIDETSAQAYVGSVAYRLSRSRR
                     IEPQLRDAASTWQVRPEDVAERLTSCPGQAHRLLREEMYRLLALSVPGRHRAVEPVELP
                     TFGGDRRYA"
     misc_feature    complement(4161..4178)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: strong, score: 20.62"
                     /tool="antismash"
     gene            4264..7263
                     /locus_tag="KOI47_RS17105"
     CDS             4264..7263
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037660.5"
                     /locus_tag="KOI47_RS17105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_216216924.1"
                     /transl_table=11
                     /translation="MVFQILGPVRLDVGNEAIDLRSVKLRGLLGILLLHANKPVHADYI
                     VDGLWGGECVPADARKTLQPYVSKVRAALKKAQTGATLATEHGHYRLRTDLLSVDYHHF
                     CHLANKGRVASQQADNDTTVHVLSRAVELWAGPPLADVTTSWAQRTREKLVLRDLHPVY
                     RLLFRTHLALGHHDHVIQELRPLLDEYETDEAFAELYLRALAGSGDMGGLTSFFGDFSS
                     RLLDEFDTQPSEWLVSLYERLVDEHRTPDLDMPITQVDPTARRSPPCQLPRDPSFFVGR
                     EAVLERLDSLLLRDGAPSVVALDGSPGVGKTTVAVHWARTRSTHFPDGQLYADLHGYGI
                     DAPTRPTTVLANFLEELGVRDRVPDDVHERAALLRHTLNGRRVLVVLDNVRDSEHVRLL
                     LTATSSCPVLITSRQKLSTLAYNEGAYTVPVTVFEPDESVSLLRHRMRDVRVAPDPAAI
                     QNLASLCGGLPLALQIVGEHVAARSNVEVQELVDQLRGERKRLLDAGSHGDGDRSTLRA
                     VFTWSCTALSSVAERLFRLLGLHPSPYVSTPAAAAVAGLTVAETERALEILLGAHLIQQ
                     QTSDGYRLHDLLHLYASDLVSREDTQERYAAVRRVLDWYLGSVVSAFRVLAPQLVDIPS
                     LRLDPNVTPRSFESPEDAMSWCVRERPQVLAVCRTAVEYGFHDHMWRLVGAFTEVLRRY
                     GDPRDLLEIHHRALESARIAGARDGEAGQLNNLGFVEFKLGEYGDAERHFRQALDIFRM
                     IDEAAGEAIALHNIANTYLERGRYRKAVQLYQESLRISEGNDDKPGQARVYHRLGDLYQ
                     RTRRLDLAAQHYRQALKLRMNVGSPGERAQTLAQLGSLLLDKGDPAAAVRHCENALTIY
                     DQTRDDRQAAEALRTLASAQLALAAHPAAAAAARRSVELCRSTGNLPGVARALDALAEA
                     CLAMGDSATARAKWNEALEISGETGVTIAGSIRDKLALLEAGDDVIPDDRTIPLFRQEI
                     GSSRPAATNW"
     misc_feature    4552..4554
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5743..5745
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6013..6015
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6025..6027
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8067..9920)
                     /locus_tag="KOI47_RS17110"
     CDS             complement(8067..9920)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007035233.1"
                     /locus_tag="KOI47_RS17110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_216216925.1"
                     /transl_table=11
                     /translation="MSPSPEVWDLDPDWPTCAAAVEPACPGIRASGFDRCLTHLTTAEF
                     ETVLDRLEPGADLDLRGTTLDSDVLERLLTALTADNERGARIGFLHGTRTRFTGTAWFA
                     RVRFEGTAGFVGARFEGTARFDDAHFARHAGFTSARFARDAGFDDAHFGGTARFAAARF
                     AGHAWFDDVRFEGTARFDDAHFARHAEFVRAHFAGNTQFACARFAGYAGFAGAHFQAAG
                     QLGPLSAAEVVLDGAVFCRRMVVEAAAHRVSCDGARFEEGMALRLRHTQVSFQNVTLGG
                     PSSIQGNPHAFPTILGAEGTPPEEDPSRAADQPEPEPGAGTYPDTEDLPVLLSVRETDL
                     SEMLLIDVDLRWCRFAGAHHLDLLRIEGRSPFDRPPTGWHAGWAWPPVWRWTRRSVLAE
                     EHHWRHDQRKSRGWRHGHDQRKARGWHSSSPGQDAVAAVGPVRLAALYRSLRKSLEDSK
                     DQAGAGDFYYGEMEARRHSGPVRDRVVLSAYWLLSGYGQRVLRPLVALAALVGVITVLL
                     VGWGLPDSPPPQQITGTLPVAEQQVTLAVRDASPTLPPAAQRWNWNRAGKAAQIAMSSV
                     VFRDGGQKLTPAGTWTIMAGRFLGPALLLLAILAIRARVKR"
     gene            complement(10001..11026)
                     /locus_tag="KOI47_RS17115"
     CDS             complement(10001..11026)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="KOI47_RS17115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_216216926.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-38, bitscore:
                     131.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHHLATPAASTGAPPDVLASAVHSVLAGTPPAEACTRHGLTDH
                     DLDDAVETYCQAGSTALYDRAADAGWWQAHLEFADWRHAEHLASTVLEPHLRDWHANGL
                     LEAWWFIRKAPCWRLRLRPANSTNALPPTAGALFDQLVDSGHLRHWQPTHYEPETLAFG
                     GPTGISIAHRLFSADSANLLHYLGHIEPPLGRRELSLLLCTTLLRAAGLEWFETGDVWH
                     RVTCLRTNPDHPSTAHGHHATLTHQLHTLLTYDTRPTGPIFGPNAPAATLRPWAEAFHH
                     AGHALATAAHHATLHRGLRAVLAHHVIFHWNRLGLHTTTQHALAHAATTAIHHHEHGTQ
                     A"
     gene            complement(11008..12249)
                     /locus_tag="KOI47_RS17120"
     CDS             complement(11008..12249)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498825.1"
                     /locus_tag="KOI47_RS17120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_216216927.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-47, bitscore:
                     160.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPPTHLGADAEHVPLIDRLTYPLATPSTTAHTGQAQSLARGAAG
                     VALWHIHQAHRNTPGARTRAHRWVQAALAEPVSNADTAGLFAGLPAITFVVHTAQDLIP
                     EYESALEKLDAHLIRLTHRRVDAALARIDRGEPASFAEYDLLRGLTGIGQVLLHFLPTS
                     DALERILRYLVRLTRPIRVEGDTLPGWWVGHGPDPSLPTPGGHANLGLAHGIAGPLALL
                     ATATRADITVQGQQDAVHAFCADLDQWRQNPDTGSWWPYWITRDNHTQRHITQRTPGRP
                     SWCYGTPGIARTYQLAALATGDTARRHTAETALASCLADDTQLNQITDLGLCHGWAGLY
                     ATAARAAADSSTPALTELLPSLAQQLLRNAATSGPSEDGFLDGAAGLALALSEAADSTA
                     PSAISGWDRCLLIT"
     gene            complement(12246..15443)
                     /locus_tag="KOI47_RS17125"
     CDS             complement(12246..15443)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="KOI47_RS17125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_216216928.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.9e-184,
                     bitscore: 613.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.1e-10,
                     bitscore: 39.9, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPRHFRHTGLVVVRASTDPGGLRLPRLDLHTAEGAETIGRAWL
                     ARTWDRGTVRTALRVASPALCKRITTAVSGTPLSRRQWRRLLVAVSSYLLRWRGRATPF
                     GLFAGVTTATIGPSPRAMFGDAHAVRARLDPDRLADLISWLEHDPAVLAHLRLTVNNAG
                     TTRGDQFVVPRPVAPARAGKTGTTSPLAGDLKAMELAVRRSRPVDAVLAAADRPVRGQE
                     LITRLERDFTASCEQVTTMLAGLIEHHILVTNLRAPATSTDPVAHLLTELDTLPPHADA
                     HDAERVATVRDALRCLHESLSEPDLDPGAPIPCPAGIPGRHRNTASGPSGTTTVAPSTR
                     PEPPAIEVAIDGRIQLPETVLHEAETAASTLLRLTRGPFGTGAWRDYHQRFRDRYGTGA
                     VVGVRELVSDAGLGYPVGFLGAARDHPVRPLTDRDAVVQRMVQEAVLDGGTEIHLSADD
                     IEQLTVGDHTQLVPPERVEIAFRLHAHSANALQRGRFQLWVTGAPPTSSSMIGRFAPLL
                     DAPARDRLAASYATSDPDVMVAQLSFPPRRPRNDAVTRVPCLMPWLLPIAEHPTVKTDT
                     DGKPGRLTLQDLAVTASATRFFLIHCPTGKRVQAHVPHALETTVFTPPLVRFIAELATA
                     RSAVWGPFDFGAARTLPFLPRIRAGRSVLAPARWLLDSADLPGPRAEPRDWQDALAAWR
                     HRWRVPAQVVLCEGEQRLPLDLEDPTQLSLLRTRLRRGTEVELRETARPADQEWIGRAA
                     EFVVPLTTTHPDRTRAMPRTGPTRSTGTDDRNASRPHLPMTSTLLMAQVDGHPQRFDTI
                     LTTHLPQLRDRIRDAAVRTWFRRHHDTTRPESDHYLQLWVRLTSTDQYGTVAAQIAEWT
                     AELRQAALAAHLRFDTAWTQPGKYGTDLPAAEQVFATDSAAALAQLGLVQDAHLPNPVV
                     AAVSMADLATALAPTPHQGWRWLTTVLGQQHGPTDPTLREHALHLAKHLGHPTHEPRPH
                     HTAAEAAVLTAWAHRRTALTEYRTRLDRDPSTVLRALLHDHVTRAVAVHPEQEEATNRL
                     ARAIALRATALASQEHP"
     misc_feature    complement(13953..13955)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14670..14972)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KOI47_RS17125_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="8.20E-13"
                     /identifier="RREFam001.1"
                     /label="KOI47_RS17125"
                     /locus_tag="KOI47_RS17125"
                     /protein_end="258"
                     /protein_start="157"
                     /score="39.9"
                     /tool="antismash"
                     /translation="TVNNAGTTRGDQFVVPRPVAPARAGKTGTTSPLAGDLKAMELAVR
                     RSRPVDAVLAAADRPVRGQELITRLERDFTASCEQVTTMLAGLIEHHILVTNLRAP"
     gene            complement(15561..15773)
                     /locus_tag="KOI47_RS17130"
     CDS             complement(15561..15773)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498823.1"
                     /locus_tag="KOI47_RS17130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_216217356.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 6e-14, bitscore:
                     50.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSATSTLPHTTNPNASAARSAASPDGDFTLDFQVIEAAYPLAKL
                     SCDTSDGCGQTCSTSACNSQANNPA"
     CDS_motif       complement(15648..15773)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSSATSTLPHTTNPNASAARSAASPDGDFTLDFQVIEAAYPL"
                     /locus_tag="KOI47_RS17130_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15561..15647)
                     /prepeptide="core"
                     /locus_tag="KOI47_RS17130_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-11.90"
                     /molecular_weight="2590.7"
                     /monoisotopic_mass="2589.1"
                     /core_sequence="AKLSCDTSDGCGQTCSTSACNSQANNPA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSSATSTLPHTTNPNASAARSAASPDGDFTLDFQVIEAAYP
                     L"
                     /leader_location="[15647:15773](-)"
                     /alternative_weights="2608.7"
                     /alternative_weights="2626.8"
                     /alternative_weights="2644.8"
                     /alternative_weights="2662.8"
     gene            complement(16286..17071)
                     /gene="fxlM"
                     /locus_tag="KOI47_RS35690"
     CDS             complement(16286..17071)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="KOI47_RS35690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_232376804.1"
                     /sec_met_domain="PCMT (E-value: 8.8e-35, bitscore: 119.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEQLWELHALRSDRVAAVFGRMDRHAFAPEVPVDEVYAATTAVV
                     TKRDEHGAAVSSISAPQIQAFMLEQADIQPGMRVLEVGSGGLNAAMLAELVGETGGVTT
                     MDIDPEITDRARTLLDAAGYSRVQVVCGDAETGLPGLGLFDVVLVTVGCWDVPPAWIEH
                     LIEGGRIVVPLRMRGITRSLSLRRTGDHLVADSAEVCGFVKIRGQGAHRERMLLLHGDR
                     IALRFDDDTCPMIPPTGQGVGDRPRRRLVRGDGRCHGTV"
     gene            17451..17780
                     /locus_tag="KOI47_RS17140"
     CDS             17451..17780
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313879.1"
                     /locus_tag="KOI47_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_216216929.1"
                     /transl_table=11
                     /translation="MQLRFLGKDTQGGGSPTLYATDRGTYVVQGWKVHGHPTRIEIPHR
                     LLGHVEEGKCLGAHLDDTGRGSFILSGRPVTDAAALATMDIPGHETCVEVPTKKEVRVS
                     ATATG"
     gene            17761..18294
                     /locus_tag="KOI47_RS17145"
     CDS             17761..18294
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313881.1"
                     /locus_tag="KOI47_RS17145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF6879 family protein"
                     /protein_id="WP_216216930.1"
                     /transl_table=11
                     /translation="MQLLQGEAFDALFREFERDAFHLEVRDTYTTPEESEPFHLFLTGR
                     HDDFAWFQPWLNLVRNATSTGRIVRRVRVVTVPHGDYTRWGLTVAEHNTAAGEDVRWLP
                     RHLINPDQLSADDFWLFDDNRVVFTVFEPDGRFAGGAATTDPVIVRHCRTVRDRVWQTA
                     VPHHRYLETEHATA"
     gene            18313..19158
                     /locus_tag="KOI47_RS17150"
     CDS             18313..19158
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010313883.1"
                     /locus_tag="KOI47_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_216216931.1"
                     /transl_table=11
                     /translation="MTHSLHQARQALGHQLRDLRKDAQLTGRDLATLAGWHSSKVSKIE
                     YGKQTPTEDDIRAWCQHTRSEPQIPDLIATVRNIESMYVEWRRMLGAGTRRRQKASQRL
                     EAKTTLMRWYEPVLIPGILQTAEYAHEVMRRVIEFYDIPDDLDAGVAERMERQNILYRG
                     DHQFHFILAQQALTTTVGNPNIMIGQLDRILAIMSLPRVVLGIIPNDAEYRVPTNQFII
                     FDNQLVHVETISAELTISQPREIDTYNKAFQSLSGQALTGPAAQNIITRAVDRFHNKRK
                     "
     gene            complement(19448..19780)
                     /locus_tag="KOI47_RS17155"
     CDS             complement(19448..19780)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216932.1"
                     /transl_table=11
                     /translation="MIYDDDPARRVYHGWLRPELPDRLFPLRHLATQRSRLAVSAPDAA
                     GALTSNPASRPRRRGQNRVTVLWVPHPDGPEQLYLRLGFTSIGQTYHGQTVAERFLDWP
                     AAGVTL"
     gene            complement(19777..>20769)
                     /locus_tag="KOI47_RS17160"
                     /pseudo=""
     CDS             complement(19777..>20769)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025080.5"
                     /locus_tag="KOI47_RS17160"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LDPARESLASSAGGLLLRQTLRLSGAQRALSGALAPWRGRRAAHD
                     PGKIVCDVAIAVALGGDCLADLAVVRAQAEVFGLVASDPTVSRLFSTLAADSAIAVPAI
                     RSARAQARAAVWARRRPLAGGPGTQDGGQVIVDIDATLVTAHSDKEQAAPTHKRGFGFA
                     PMCAFVDHGEHGTGETLVAQLRPGNASPWNKQDHIEAVDLALAQLPERERAHVLIRADS
                     GRLLQSAAAASRRPGGGILDRVPRARNRQDRTGDHPGAGLARRPRQRRPTARGCAGRRT
                     HCLDAHTDPASRPGPQDWPPGMRVIARRQRPHPGAQLRLTGNRPPHGPG"
     misc_feature    complement(21562..21578)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 20.22"
                     /tool="antismash"
     gene            21597..22487
                     /locus_tag="KOI47_RS17165"
     CDS             21597..22487
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216933.1"
                     /transl_table=11
                     /translation="MDHDVHGICNLAPICGACNKAKSGMDLSATGLLLSMLHKARKLAP
                     EITRQVVAFGSPSKLESALLEATEADLSDTRTREIFERSAPAVVQRLAELGDGKADYFV
                     FKEVRVEASESPLYTCGPPVMVRVGLKLYECGRASMTVLERVVGGRLEVALRVPLSDLL
                     ELIATTVGSAFERYSENPDASKAGEVNIEWPEITIDRVEFDSRSPIDLEFEFAGEFRVA
                     ATAGVAWVSQRDGSLEDVQGDATVSGRFRFELSWAPGVAIGKFHFGQVWLEDWQADVWI
                     TPGRESLRCQLSGSH"
     misc_feature    21675..21677
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    22083..22085
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22555..22959
                     /locus_tag="KOI47_RS17170"
     CDS             22555..22959
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216934.1"
                     /transl_table=11
                     /translation="MTAPAYLLKWPTSDQLPATFFTPTWLLPEGDPTRPWEEILDVLFW
                     KVHQIEHATLAARLDHVVAFLGVGAALKQDIGRHTFHFVPVACDHAIDLCDAFLRDKPL
                     PAESSIVTEVLERLGKAMQPAKRAARDFQH"
     gene            23204..23875
                     /locus_tag="KOI47_RS17175"
     CDS             23204..23875
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012257.5"
                     /locus_tag="KOI47_RS17175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_216216935.1"
                     /transl_table=11
                     /translation="MPDDHAHRGFRALVPERTWSTLCKLGFLRTFSKGEPIFVRGAPAS
                     SVLLLTSGRVEVGCHTEDGDYRLIALRGAGDVIGEVAFEVGGVRTADVFALEPCAAFAV
                     PSHTFERVLVADGVHREVRRYVAAKLQRAGQDSVDMLSLPPLRRIARLMVQLADLAEPG
                     HNPRLIPMSQTRLGHVLGLSRSLVAGLVAQLRREGVLSAERNLTVERFDKLRRHAYLSQ
                     E"
     gene            23943..24848
                     /locus_tag="KOI47_RS17180"
     CDS             23943..24848
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS17180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216936.1"
                     /transl_table=11
                     /translation="MTEDTHSVAYELPPYHAVLSVDVKNFSGVTPADHYALTELIPTIL
                     ERAFERAEHAATWADRRFPAGRGDGFVVGFRPESLPILVGPFLDALQDELAYHHRMRLG
                     RNGEPTRLRVSVAVGPLTDSGNAQLGDGSGAAMVETHRLLDCEPVRELLASSDPEVTFV
                     AAVLSARVYEDVVLSGYAAKAPGEFVRVPVSVKSYVGDAYLHVPKPSGDLLSRGIGTPD
                     EPFPDGPVSQDEAPGANSAVANTSNGTVYGNTIQMRDEYRRTDKSRNSHQHTVGDGNIV
                     TGGNLRGGIRQNVRKNGEKN"
ORIGIN
        1 gctcgccgtg gtgacgagtc gccgaccgct gttggggctg ctggcagccg gtgcgcacgc
       61 agttcaggtt gatccgctgg accccgacgg ggcactcgaa ctgctttcgt atcgtgtggg
      121 aaaccagcgg gtgcgacgtg aacggaaccc ggcgacagcg ttggtccacc tgtgcggcgg
      181 attgccgatt gcgctgtgtg tagcagcggc tcgagtggcg tcgcgccccc gacgtccgct
      241 cgcccgcatg gtcgatgacc tttccaacga gcggctgcga ctggaccggc tgtcggccga
      301 ggaggacctc tccgtgcgtt ccatgttcga cgtcgcctac accgacctcg acgtgcatgc
      361 gcgacgggtg taccggacga tgggacttca tcccggtggt ctcttcgccg ccgaggtggc
      421 gtcggcggcg ctcgagatgg gcgttgctga cgcccgggat gcgttggacg gcttggttga
      481 tgccagcctc ctcgaagagg tggacgaccg ccactaccag tttcacgatt tggtgcgggt
      541 ccacgcgcag gaccaagcac tccagcacga tagtgatcac gatcgagcga ccgtggttcg
      601 gaagatgctg gactggtacc tgttcgcggc gaggtccatg agtgaggtcg tgatgccggc
      661 gcgtcgcgtg ctcgactacg ccttcgagcc gtcggcggat acgttcaccc tgccggacga
      721 cgtagcaggg cacgaggcag ccctggactg gctggagcgc caccgtctgg tcctgatcgc
      781 tgctacgcga gaagccgccc aacgacagtg ggccgagctt gcctaccact tggctgatgt
      841 tctccagccg ttgttcatcc tgcacaagca tgagcgtcag gcgctcgagg tcggcgaggt
      901 cgcgctgcgg gccgcccgtg aatgggggag tgtgcgtgcg gagaacagta cacagaaacg
      961 cctggccaga gcgtacgcgc acctcggacg cttcgaccag gccgagcagc atgccgagga
     1021 gatgctgcac cgcactcgcg accgggctga ccggcgagga gaggccagtg cgctgaagaa
     1081 cctggccttc ctccaggcgg agaccggaca gttcgacctt gcggcggcga cgtttgatca
     1141 gaccctggcg attctgcgag cgttgggaaa acgccggggt gaggcgctga cgctcgtgga
     1201 gttaggccgg acgcttatcc gattgggcga ttttgaacgg gccgctgaac ggctgcgtag
     1261 agcgcgtgac ctgttcgcca gcctggacgt gccggatcgg tacaacgacg cgcgggccgc
     1321 ggcctccctc ggagcggcag agatgtacct ggagcgccac gacaccgctc gtgctctcct
     1381 gcagggcgca gtgaccgtac tcgccgagca tggagcgcac cagcagcgtg gccaggttca
     1441 tcgagccctg gccgagctgg ccaggcgagt cggtgattcg gccgaggctc ggcggcagga
     1501 cgacatcgcc gaggctctcg gaacggcggc cgactcgcgc tggccgtaga cccgttcacc
     1561 gtagttgcgt cgcgccaggt aacccgtgcg tggcacgcag cctcgcgagc cgttcccgcg
     1621 gaacgcctac atcctcgtcc ggatgcccgc ctaccttcca gccggccgcc agcaccgcgt
     1681 tgcgcgtcgc cgccacggcg tccccaaggc gcaggtagtg atgcacgaaa gacgccagaa
     1741 acgtgtcccc ggcaccgctg acataccgaa ccccgcgtgg agcgcacgac tcgacccgcc
     1801 agatgcggcg agaacgccga tcaccgacaa cgacaccccc cggaccacat ccgaccagtg
     1861 tgatgctggt gccgaaccgc cgccacgttt cgcggatcca tgactctggg ttcgtcggta
     1921 accgctcgtg tgaacaggcc agcacgtggg ctgctcgcat ccagtcgcgg ttgtactcgc
     1981 agtccgccga ctcgacgaga tgtagatcgg taatcaccgg gatcccccgg tcgatcacgc
     2041 tggggagcaa cgatcgggtg aagccgatgt tggtcagcag agccgcctcg caaccggcgt
     2101 ccagcatcgg ttgcacgacg tgagccgggt atcggaggtc cggagtggac cgcaggtcgg
     2161 tcacgtttgc ccgccgtccg tggcggtcgt aaagaaccat cgcgcgtggt tgtgagtcac
     2221 accgaagcgc cgtggctccg aggtgcccgt actgtgccag ctgctgggcg accagatttc
     2281 cgagttcgtc cgtgccgacg taggttgcga aggcgacatc ggtaccgagc tgctccagtg
     2341 ttcgggtcag tgtccatcct gtaccggaaa gacgcacgct gatgccaccg ttgtcgacca
     2401 cactggacgc aggtcgctta cggaaggtgc cgacaccacg ggcgatccgg acgttgacca
     2461 cacctgcgac gagcaccaga tacggatttc ggcctggggg aacggaaccg gtagtcatca
     2521 tgtcctggac accgccctca ggtagatccc ctcgaccagg cgttcgacca cggcacgcgt
     2581 cgctggttcg gcaccgcttc ggcaggtgtg tactcgcccg tcaccgcgga tggttatcag
     2641 ccaccagcgg ccgtcctcgt gccgggcaac tgcgatcgaa cagcccggat atcggtcgaa
     2701 cacccgaccg agccatcgga cgccggactc ccgagtcgga tggtcggcca acaggacatc
     2761 agcactttgc agtcgtgcgc ggttgctgtc cggctcgacc gcgatggccg ggccgaggtc
     2821 gtcggtgatg tcatgcataa cggcggtcac caccaaacgt gggaagttcg accggctcta
     2881 ccgcgcggtg ccgaccgggg accgacaacg ccagtagccg gtacatctcc tcgcggagaa
     2941 ggcgatgtgc ctgtcccggg caggaggtca accgttcggc cacgtcttcg ggccgcacct
     3001 gccatgtgga cgcggcatcg cgcagttgcg gctcgatccg cctcgaccgc gacagccggt
     3061 atgcgaccga accgacgtag gcctgtgcag acgtctcatc gatctcttcg gatgggaacg
     3121 atgcctgcag gaccggcttg ccaatggcgg ctgcgtaggt ggaaacggat ccatggtcgc
     3181 caaccacgta gtcggcggcg atcaacaccg agcgccagtc cacgtccgga ccggcgacga
     3241 tcaagccggc cgctcgctgg tcggtgaacc acgagcggac ctgccggatc ccgtgaccga
     3301 accacaccgc tggatggaac aaagccgctg ctcgatagcg gtttcggggc agctcgtcga
     3361 tcaacgcgga gatcaggcgc atcgatcggg cgagaagtga atgaggaccc cacgtcgatg
     3421 cgatcacgac caatcgctgg ccgggctgga tgccgatagc gtcccggcag ctgtcccgca
     3481 gctcgaggct ggctcgcaat ctgtcgtagc acggatcgcc ggctaccagg gcgacatccg
     3541 cggccggcgg gcactggcgc gcgaggacct cccgttgggc gaagtgcgag agcacgatcg
     3601 aggacggcac gacgcggccg tctcggacca ggtgttccgt gccgaggccg tagacggccc
     3661 gtcctgtggt cgggccgttg ccgtcaccct gcggcgtttg cttcgcgtat ccggcgccgt
     3721 gtggcagtac catgatcggc gcgtggagtt gggccagtcc gccgtatgcg gctgcgatcg
     3781 cgaggtcgaa ctgttcgcgg acggcctgtt gccacggaat ctccaatgcg ccgatcgagc
     3841 gcaggaactc ctcgacgccg ccgtggaaga tgtccgggcc gcgggtatag acgacctgta
     3901 cccgcggatc ggattcgatg aggccgacga tgtccagcag gcgttgccct gacacgacgg
     3961 tgtgcacgac cacgagaacg gttcgcctgc ttcctcgcgt tgtccaccgc ttcgcgtcga
     4021 tgccgatcgg caccgctgac cactctggct cgttcacggt ctctcccctc gacaagtggc
     4081 ggaatcgctg gagttctgac cgtgcgagcc tcactgagca aaccggttgc aatccgctga
     4141 ccaatggact gctacctgtt gtaacaatgg gataacatga tgtgatcatg ttgtcctcgg
     4201 ttgtgcgatg cggtcacact gcctgttggg agggctgtgc cattcaggcc ggggagagtg
     4261 cccgtggtgt tccagattct gggaccggtg cgcctcgacg tcggaaacga ggccatcgat
     4321 cttcgatcgg tcaagctgcg gggcctactt gggatactgc ttctgcacgc gaataagccc
     4381 gtgcacgccg actacatcgt ggacggcctg tggggcggcg aatgtgttcc ggctgatgcg
     4441 cgcaagaccc tgcagccata cgtatcgaag gtgcgtgcgg cactgaagaa ggctcagacg
     4501 ggcgcgacgc tggccacgga gcacggtcac tacaggcttc ggaccgacct gttatcggtc
     4561 gactaccacc atttctgtca tcttgccaac aaggggcggg tcgccagtca gcaggcggac
     4621 aacgatacga ccgtccacgt cctgagcagg gcggtcgaac tctgggcagg accgccgctg
     4681 gcggacgtga cgacgtcctg ggcgcaacgc accagggaga agctggtcct gcgggatctg
     4741 catccggttt atcgtctcct gttccggacc cacctggcgc tcggccacca tgaccacgtc
     4801 attcaggaac tgcgcccgct cctggacgag tacgagacgg acgaggcgtt cgccgagctg
     4861 tatctcaggg cgctggccgg atccggcgac atgggaggcc ttaccagctt cttcggcgac
     4921 ttcagctctc gactactcga tgagttcgac actcagccca gcgagtggtt ggtgtcgctc
     4981 tacgagcggc ttgtggacga acaccgaacg cccgacctcg acatgccgat cacgcaggtc
     5041 gacccgacgg cgcgcaggtc gccaccatgc cagcttccgc gtgacccctc cttcttcgtt
     5101 ggcagggaag ctgtcctgga acgtctcgac tccctcctgc tcagagacgg ggctccatcc
     5161 gtcgtcgcac tggacgggag tccgggtgtg ggcaagacga ccgtcgccgt tcactgggca
     5221 cgtacccgca gtacccattt cccggacgga caactgtacg cggacctcca cggctacggg
     5281 atcgacgcac cgacgaggcc gacgaccgtc ctggccaact tcctggagga gctgggagtc
     5341 cgcgaccggg ttcccgatga cgtccacgaa cgggccgcgt tgctgcgcca caccttgaac
     5401 ggacgccgag ttctggtcgt gctggacaat gtgcgcgact ccgaacacgt gcgacttctg
     5461 ctcacggcga cgtcctcgtg cccggtgctg atcaccagca gacagaagct cagcaccctc
     5521 gcctacaacg agggggccta caccgttccg gtgacggttt ttgaaccgga cgagtcggtg
     5581 agcctgctgc ggcatcgcat gcgggatgtg cgcgtggcac cggacccggc cgcgatacag
     5641 aaccttgcct cgctgtgcgg aggactgccg cttgcgctac agatcgtcgg ggaacacgtg
     5701 gcggcacgca gcaacgtcga ggtccaggaa ctcgtcgacc agttacgcgg cgagcgcaaa
     5761 cggttgttgg acgccggatc gcacggagac ggagaccgtt cgacgctccg cgctgtcttc
     5821 acatggtcgt gcacggcact gtcgtccgta gcggagcgcc ttttccggct gctcggcctg
     5881 cacccgagtc catacgtgag cacaccagcc gccgccgcgg ttgccggcct caccgtggcc
     5941 gagactgagc gcgcactcga gatacttctt ggcgcacacc tgatccagca gcaaaccagc
     6001 gacggctatc gcttacatga cttgttacac ctctacgcga gcgacctggt gagtcgggag
     6061 gacacccaag aacggtatgc tgccgtccgg cgcgtactcg attggtatct cggctccgtc
     6121 gtcagcgctt ttcgggttct cgcgccacag ctggtcgaca ttccgtcgtt gcgcctggat
     6181 ccgaacgtga cgcctcggtc attcgagagc cccgaggacg cgatgagctg gtgcgtgcgc
     6241 gagcggcccc aggtgctggc cgtctgccga actgcggtcg agtacggctt tcacgatcat
     6301 atgtggcgac tcgtcggcgc gttcaccgag gtactccgcc ggtacggcga tcctcgcgat
     6361 ctgctggaga tccaccatcg cgcgctggag tcggcgcgta tcgccggcgc acgagacggt
     6421 gaggcagggc aactgaacaa cctcggattc gtcgagttca aactcggcga gtacggcgac
     6481 gccgaaagac acttccggca agcgctcgac atcttccgga tgatcgacga ggccgcaggc
     6541 gaggcgatag ccctccacaa catcgccaac acgtacctcg aacgcggccg gtaccgaaag
     6601 gcggtgcagc tgtaccagga aagcctccgg atatccgagg gcaacgacga caagccgggg
     6661 caggcccggg tgtatcaccg tctcggcgac ctgtaccaac gaacgcggcg gctcgacctc
     6721 gcagcacagc actaccgcca ggcactgaaa cttcgcatga acgtcggttc ccccggggag
     6781 cgagcgcaga cactggcgca gctgggcagc ctcctgctcg ataagggcga tccggcagcc
     6841 gccgtgcggc actgtgagaa cgcgctcacc atctatgacc agacacgtga tgatcgtcag
     6901 gccgccgagg cgctccgaac acttgcctcc gcgcagctgg cgctcgctgc gcatcctgcc
     6961 gccgccgcgg cggctcgacg atctgtggaa ctgtgccgct ccacgggcaa tctccccggc
     7021 gtggcccgag cgctcgatgc tctcgccgag gcatgtctgg cgatggggga cagcgcgaca
     7081 gcgcgcgcga aatggaatga ggcgctagag atatcgggtg agaccggcgt tacgatcgca
     7141 ggctcgatac gcgacaaact tgcgctgctg gaagccggag atgatgtcat cccggacgac
     7201 cgaaccattc cattgtttcg gcaagaaatt gggagttcgc gcccggcggc gaccaactgg
     7261 taggggcgcg aaccggtggc gcgactccta ctgggcagta gccaaaatgg tgggctggta
     7321 ccagtcagtc gacggagccg ccgtgtatgt ggtcgtgacc ggcgtgctcg gtgcggacaa
     7381 gaacagcgcc ccggcaaggc atagtccagc ggctactcgc agggtcgagt gcccgcccgg
     7441 catgtggttc atgaggtatt tggtacgcat gtggccagtg tcgcagttct ggcgatcggt
     7501 gactccgctg ggggactcct atggaaggac cacctggcgg tataagctac tccgtttagc
     7561 cctcaagtgg catgatctcg caacgcgctc cctccttctg gttcgggcga tgtcaccgaa
     7621 cgtgtcgata tgctactgtg ggtggtcccg tcgtcctggg tgctaactcg gcgccgcgtg
     7681 gtcgtggcaa gctgatcgct ggatgctggg aacgaattgt cgggcttgtt ttgataattt
     7741 gttcaccgaa cgcttggatt cgggcttgat atccaaggtt gcgggaaacg caagcggtag
     7801 cctgcagttc attcagatat tcctgactgt tcagaattgg cgatatcaaa ttacgccccg
     7861 ggagtctcgg tcgagtcctg acgctatttc tcacaacagt tatgattcga gtcttggaac
     7921 ctggaccggg acggataaca acaactcgtc aagccccgcc cggcatatcg ccgagcgacc
     7981 tgggcggctg ttggtctctg atgggccggt tcaccggcag atgtcggtgc cccgggcccg
     8041 tttcgggtgt gctccgaggt gcggcgttag cgtttgactc gggcacggat ggcgaggatc
     8101 gccaggagga ggagtgcggg gccgaggaag cgaccagcca tgatggtcca ggtgccggcg
     8161 ggggtgagct tctggccgcc gtcgcggaag acgaccgagc tcatcgcgat ctgtgccgct
     8221 ttgccagcac ggttccagtt ccagcgctgc gctgccggtg ggagtgtggg cgaggcgtcg
     8281 cgcacggcca gggtgacctg ctgctcggca acgggcaggg tgccggtgat ctgctgtggg
     8341 ggtggggagt cgggcaggcc ccagccgacc agcaacacgg tgatcactcc gaccagggcg
     8401 gcgagggcga ccagggggcg caggacgcgc tgcccatagc cggagagtag ccagtaggcg
     8461 ctgagcacga cccggtcccg tacggggccg gagtggcggc gggcttccat ctcgccgtag
     8521 tagaagtccc cggcgccggc ttgatctttg ctgtcctcca gcgatttgcg cagggatcgg
     8581 tacagcgcgg ccagccgtac cggcccgacc gcagccaccg catcctgccc aggtgaggag
     8641 gagtgccagc cgcgggcctt gcgttggtcg tggccatggc gccagccgcg gctcttgcgt
     8701 tggtcgtggc gccagtggtg ttcctcggcc agcacagacc ggcgagtcca gcgccatacc
     8761 ggtggccacg cccagcccgc atgccagccg gtcggaggcc ggtcgaacgg gctgcggccc
     8821 tcgatccgca gcagatccag gtgatgcgcc cccgcgaacc ggcaccaccg tagatcgaca
     8881 tcgatcagca gcatctcgga cagatcggtc tccctcaccg acaacaacac cggtaggtcc
     8941 tcggtgtccg gataagtccc agctccgggt tccggttctg gctggtccgc cgccctggac
     9001 ggatcttcct ccggcggcgt cccctcggcc ccgaggattg ttgggaaggc gtggggattt
     9061 ccttggatcg acgaaggacc gcccaaggtc acattctgga agctgacctg cgtgtgtcgc
     9121 aggcgtagcg ccatgccctc ctcgaaccgg gcaccatcgc acgacacccg atgcgcggcc
     9181 gcttccacca ccatccgccg acagaacacg gccccatcca gaaccacctc cgcggcactc
     9241 aacggcccca gctggccagc cgcctggaag tgggcgccgg cgaacccggc gtaccccgcg
     9301 aagcgggcgc aggcaaactg ggtgttcccc gcgaagtggg cgcggacgaa ctcggcgtgc
     9361 ctcgcgaagt gtgcgtcgtc gaacctggcg gtcccctcga agcggacgtc gtcgaaccag
     9421 gcgtgtcccg cgaagcgggc agcggcgaac ctggcggtcc cgccgaagtg tgcgtcgtcg
     9481 aacccggcgt ccctcgcgaa gcgggcgctg gtgaacccgg cgtgcctcgc gaagtgtgcg
     9541 tcgtcgaacc tggcggtccc ctcgaagcgg gcgccgacga acccggcggt cccctcgaaa
     9601 cggacgcggg cgaaccaggc ggtgcccgtg aagcgggtgc gtgtgccgtg gagaaagccg
     9661 atgcgcgcac cgcgttcgtt atctgcggtc agggcagtga gcaggcgctc gaggacgtca
     9721 ctgtcgaggg tggtgccgcg taggtccagg tcggcaccgg gctcgaggcg gtccaggacg
     9781 gtctcgaact cagccgtggt cagatgggtg aggcaacgat cgaacccgct ggcccggata
     9841 ccgggacagg ctggctccac cgccgccgcg caggtcggcc agtccgggtc gaggtcccac
     9901 acctctggcg acggtgacat cgctccgttc tagcacctca tcccgattcc gctcttgcca
     9961 cgtcgcgatc ctccgcgcat tgagctggtc gcaggggtgc tcatgcttgg gttccgtgct
    10021 cgtggtggtg gatggcggtg gtggcggcgt gggcgagtgc gtgttgtgtg gtggtgtgga
    10081 ggccgagtcg gttccagtgg aagatcacgt ggtgggcgag gacggctcgg agcccgcggt
    10141 gcagggtggc gtggtgtgct gcggtggcga gggcgtgtcc ggcgtggtgg aaggcttcgg
    10201 cccagggccg gagggtggcc gcgggggcgt ttggtccgaa gatgggtccg gtgggtcggg
    10261 tgtcgtaggt cagcagcgtg tgcagttggt gggtcagggt ggcgtggtgg ccgtgcgcgg
    10321 tgctggggtg gtcggggttg gttcgtaggc aggtgacgcg gtgccagacg tcgccggttt
    10381 cgaaccattc caggcctgcg gcacggagga gcgttgtgca cagcagcagg gagagctcgc
    10441 gccggccgag gggtggctcg atgtggccga ggtagtggag caggttggcg ctgtcggcgc
    10501 tgaagaggcg gtgggcgatg ctgattccgg tcggtccgcc gaaggccagg gtctcgggtt
    10561 cgtagtgggt gggttgccag tggcggaggt gtccgctgtc gacgagctgg tcgaagaggg
    10621 ctccggcagt gggcggcaag gcgtttgtgc tgttggcggg gcgtaggcgg aggcgccagc
    10681 agggcgcttt gcggatgaac caccaggcct cgagtagccc gttggcgtgc cagtcgcgta
    10741 ggtgtggctc gaggacggtg ctggcgaggt gttcggcgtg gcgccagtcg gcgaactcca
    10801 ggtgcgcctg ccaccatccg gcgtctgcgg cgcggtcgta cagggcggtg ctgccggctt
    10861 ggcagtaggt ctccaccgcg tcgtcgaggt cgtggtcggt gagtccgtgg cgggtgcagg
    10921 cctcggcggg tggggtgccg gccaggacgc tgtgcactgc ggaggccagg acatccggcg
    10981 gggcgccggt gctggcggct ggggtggcta ggtgatgagc aggcatcggt cccatccgga
    11041 tatggcactg ggtgcggtgc tgtcggcggc ttcgctcagg gcgagggcca ggcccgcggc
    11101 gccgtcgagg aatccgtcct cggacggtcc gctggtggcg gcgtttctga ggagctgttg
    11161 ggccagggac ggcagaagct cggtaagcgc gggggtgctg ctgtctgcgg cggcgcgtgc
    11221 ggcggtggcg tagaggcctg cccagccgtg gcagaggccg agatcggtga tctggttcag
    11281 ttgcgtgtcg tcggcaaggc aggaggccag cgcggtttcg gcggtgtgcc gccgggcggt
    11341 gtcgccggtg gcgagtgcgg cgagctggta ggtgcgggcg atgccggggg tgccgtagca
    11401 ccaggacggg cgtccaggag ttcgctgggt gatgtgccgc tgggtgtggt tgtcgcgggt
    11461 gatccagtac ggccaccacg agccggtgtc ggggttctgg cgccattggt cgaggtcggc
    11521 acagaaggcg tggacggcgt cctgctgtcc ttgcacggtg atgtcggccc gggtggcggt
    11581 ggcgaggagg gccagggggc cggcgatgcc gtgcgcgagt ccgaggttgg cgtgcccgcc
    11641 gggtgtgggc agcgaggggt cggggccgtg gccgacccac cagccgggca gggtgtcgcc
    11701 ctcgacccgt attggtcggg tgagtcgcac gaggtatcgc aggattcgtt cgagcgcgtc
    11761 ggaagtgggc aggaagtgca gcaggacttg gccgatgccg gtcagtccac gcaggaggtc
    11821 gtactcggcg aaggaggcgg gctcgccccg gtcgatccgg gccagcgccg cgtcgacacg
    11881 gcgatgggtc agccggatca ggtgggcgtc gagtttctcg agggcggatt cgtactcggg
    11941 gatgaggtcc tgcgcggtgt ggacgacgaa ggtgatggcg ggtagtccgg cgaacagccc
    12001 ggcggtgtcg gcgttgctga ccggttcggc cagtgccgcc tgcacccacc gatgtgcccg
    12061 ggtccgggcg cctggagtgt tgcggtgcgc ctggtggatg tgccataggg cgacaccggc
    12121 ggccccgcgt gccagcgact gggcctgccc ggtgtgcgcg gttgtgctcg gtgtcgcgag
    12181 cggataggtc agtcggtcga tcagcggtac gtgctcggcg tcggcaccga ggtgggtcgg
    12241 gggcctcatg ggtgctcctg ggaggcgagt gccgtggcgc gcagggcgat cgcgcgggcg
    12301 agccggttgg ttgcctcttc ctgttcgggg tggacggcga ccgcgcgggt gacgtggtcg
    12361 tgcagcagcg cccgcagcac ggtcgacggg tcgcggtcga ggcgggttcg gtactcggtg
    12421 agagcggtcc ggcggtgcgc ccacgcggtg agcaccgcgg cttcggccgc ggtgtggtgt
    12481 ggtcgtggtt cgtgggtggg gtggccgaga tgctttgcga ggtgcagggc gtgctcgcgc
    12541 agggtggggt cggtcgggcc gtgctgctgg ccgaggacgg tggtcagcca tcgccatccc
    12601 tggtgtggtg tcggggcgag cgcggtcgcc aggtcggcca tcgacacggc ggcgaccacc
    12661 gggttgggta gatgagcgtc ctggacgagg ccgagctggg ccagcgcggc ggccgaatcg
    12721 gtcgcgaaga cctgttccgc tgcgggaagg tcggtgccgt acttgccggg ctgggtccac
    12781 gcggtgtcga agcgcaggtg cgcggccaac gcggcctggc gcagctcggc ggtccattcg
    12841 gcgatctggg ccgcgaccgt gccgtactgg tcggtgctgg tgagacgcac ccagagttgc
    12901 aggtagtggt cggattcggg gcgggtggtg tcgtggtggc ggcgaaacca cgtccgcacg
    12961 gcggcgtcgc ggatgcggtc gcggagttgc gggaggtgcg tggtgaggat ggtgtcgaac
    13021 cgttgtggat ggccgtcgac ctgcgccatc agcagcgtcg aggtcatagg caggtgagga
    13081 cgggacgcat tccggtcatc ggtgcccgtg gacctggtgg ggccggtacg cggcatcgcg
    13141 cgcgttcggt ccgggtgcgt ggtggtgagc gggacgacga actcggctgc gcggccgatc
    13201 cactcctggt cggcgggccg ggcggtttcg cgtagttcca cctcggtccc gcggcgcagc
    13261 cgggtacgaa gcaggctgag ctgggtgggg tcctcgaggt cgagtggtag ccgctgctcg
    13321 ccctcacaca gcacgacctg cgcgggcacg cgccaccggt gtcgccacgc ggcgagcgcg
    13381 tcctgccagt cgcgcggttc cgcccgcggg cccgggaggt cggctgaatc caggagccac
    13441 cgtgctggtg ccagcacgct tcgcccggcc cggattctgg gcaggaacgg caaggtccgg
    13501 gcggcgccga agtcgaacgg cccccagacc gcgctgcggg ccgtggccag ctcggcgatg
    13561 aaccgcacca gcggtggggt gaacaccgtc gtttccagcg cgtgcggcac gtgggcctgg
    13621 acccgctttc cggtcggaca gtgaatcagg aagaaccgcg tggcgctggc ggtcaccgcg
    13681 aggtcctgca gagtaagacg gcccggcttg ccgtccgtat cggtcttcac agtggggtgt
    13741 tcggcgatgg gcagcagcca cggcatgagg cacgggaccc gggtgacggc gtcgttgcgc
    13801 ggccgccgtg gtgggaacga tagttgcgcc accatcacgt cggggtccga tgtcgcgtag
    13861 ctggcggcca accggtcgcg ggcgggcgca tcgagtaggg gagcgaagcg tccgatcatg
    13921 ctgctggagg tgggcggagc gcccgttacc cataattgga agcgtccgcg ctgcagggcg
    13981 ttggcggagt gggcgtgcag gcggaaggcg atctcgaccc gctcgggcgg gaccagctgc
    14041 gtgtggtcgc ccacggtgag ttgctcgatg tcgtccgcgg acaggtggat ctcggtgcct
    14101 ccgtcgagca cggcctcctg gaccatccgt tggacaacgg cgtcgcggtc ggtcagcggt
    14161 cgcaccgggt ggtcgcgggc ggcgccgagg aaccccaccg gataccccag gccggcatcg
    14221 gagaccagct cgcggactcc caccacggcg cccgttccgt agcggtcacg gaagcgctgg
    14281 tggtagtcgc gccaggcgcc ggtgccgaac gggccgcggg tcagccgcaa caacgtcgac
    14341 gccgcggtct cggcctcgtg tagcaccgtt tccggcagtt ggatacgccc gtcgatggcg
    14401 acctcgatcg ctggcggctc cggcctggtc gagggcgcga cggtcgttgt gccgctcggg
    14461 ccgctcgcgg tgttgcggtg ccgaccgggg atgccggcgg ggcacggtat cggggcacca
    14521 gggtcgagat cgggctcgga tagcgattcg tgcaggcaac gcagcgcatc gcggactgtg
    14581 gccacccgtt ccgcgtcgtg ggcatcggcg tgcggcggga gggtgtcgag ttcggtgagc
    14641 aggtgggcca ccggatcggt gctggtggcg ggagcccgca ggttcgtcac cagaatgtgg
    14701 tgctcgatca gcccggccag catcgtggtg acctgctcgc acgaggccgt gaagtcccgc
    14761 tccagccgcg tgatcagctc ctgcccgcgc acaggtcggt cggctgcggc gaggacggcg
    14821 tccactgggc ggctgcggcg caccgccagc tccatcgcct tgaggtcccc ggcgagcgga
    14881 gacgtggtgc cggtcttgcc cgcgcgggcc ggggccaccg gcctgggcac gacgaactgg
    14941 tccccgcggg tcgtcccggc gttgttgacg gtcagtcgga gatgggccag cacggcgggg
    15001 tcgtgttcca gccaggagat caggtcggcc agccggtccg gatcgaggcg tgcgcgcacg
    15061 gcgtgggcgt cgccgaacat ggcccggggc gatgggccga tcgtggccgt ggtgacaccg
    15121 gcgaacaggc cgaacggggt tgctctccct cgccaccgca ggaggtagga cgacacggcc
    15181 acgaggagtc gtcgccactg ccgacggctc aacggggtgc ccgacacggc ggtggtgatc
    15241 cgcttgcaga gggcagggct ggccacccgc agcgcggtgc gcacggtccc gcggtcccac
    15301 gtccgcgcca accatgcgcg gccgatggtc tcggcgccct cggcggtgtg cagatccagc
    15361 cggggcaggc gcagtccgcc cgggtcggtg ctggcccgca ccaccaccag cccggtgtgg
    15421 cggaagtgcc gtggtgctgc catacgcgtg cgcctcctcc tcgcggccgc ttcgaatggc
    15481 ccaccgcgtg ggcatggcgt ggaagcgggt gcgttgacgc cgcaacgggg catggcgtca
    15541 acgcacccga cgtggggtgg tcaggcgggg ttgttggcct ggctgttgca ggcactggtc
    15601 gagcaggtct ggccgcaccc gtcgctggtg tcgcaggaca gcttcgccag tgggtaggcc
    15661 gcctcgatca cctggaagtc gagcgtgaaa tccccgtcgg ggctggcggc ggagcgcgcg
    15721 gccgatgcgt tggggttcgt ggtgtggggc agcgtgctgg tggcgctgga catccttcgg
    15781 tccttcctgt gtcggttgtc ctccggaacc tggccgtgcc cgccggcccg tggtgtcagg
    15841 ccgtggggct ggccaggaga tcgcgacgcg ggtgtgccgt ttgtcgatca ccgccaccgt
    15901 gcggggtgga tccgggttgg ccggttcgtc ggcgtgggcc tggtggacca ggtcgtcggg
    15961 ggcggtgcgc ggccagatgg tgatgaccgg gtcggggccg cgccggtggt ggcgatccca
    16021 cgtgcgaacc tgctcggcca gcgtcttcgc cgccgcgtgg gcttgggggc cgaatccatg
    16081 ggcccccatc tcgaacacac ccggtcgcag tcgtcgactg gccaggtagg cgaaggaatc
    16141 cccgctgtcg tagacggagg cgctggggaa ccatcggcca cctggctcgg ccatcaccgg
    16201 gtcgccctcg gcggggacgt agtcgctgtc gacggccagc aggcagaacc cgggcagcac
    16261 actggccagc cacagcacca gcgagtcaaa cggttccatg gcaccgaccg tcaccccgga
    16321 ccaggcgtcg gcgcggtcgg tcgccaacac cctgtccagt gggagggatc atggggcagg
    16381 tgtcgtcgtc gaaacgcagc gcgatccggt ccccgtgcaa cagcagcatc cgctcccgat
    16441 gcgccccttg accgcggatc ttcacgaagc cacacacctc ggccgagtcc gcgaccagat
    16501 gatcaccggt gcgccgcaag ctcaatgacc gggtgatccc gcgcatgcgc aggggaacga
    16561 cgatccgtcc accctcgatg aggtgctcga tccacgcggg cggaacatcc cagcagccca
    16621 cggtcaccag gacgacatcg aacaggccga ggccgggcag gccggtttcg gcgtcgccgc
    16681 acacgacctg aacgcgggag tatccggcgg cgtccaggag ggtgcgggcc cggtcggtga
    16741 tctcggggtc gatgtccatg gtcgtcacac cgccggtctc gccgaccagt tcggccagca
    16801 tggccgcgtt gaggccgccg gaacccacct ccagcacccg catacccggc tggatgtcgg
    16861 cctgctccag catgaacgcc tgaatctgcg gtgcgctgat cgagctgacg gcggcaccgt
    16921 gctcgtcccg tttggtcacc accgcggtcg tcgccgcata cacctcgtcc accggcacct
    16981 cgggggcgaa ggcatgccga tccatcctgc cgaacacggc ggcgacgcga tcggagcgca
    17041 atgcgtgcag ctcccacagc tgttcgatca tcgccgcccg tgctctggcc acacgcttcg
    17101 cggtcagggc atccctgccc ggggcagtat cggatccggc gcttgtgtcg tggtcgcggc
    17161 ctgcggtcac ctggctgctc gtccccttgc gtggtctggt gtcggaaatc cccgtgctgt
    17221 gtccgctgcc ggcaccgcgg aggcgcatgg tgtgtcgttc gcggggatgg cacggatcag
    17281 cacggcggcg atcacgctag ggcgagccgt gacgaccggg ccagaagttt gctccagttt
    17341 gctcgaagat accctgaccg tgtggccgtt tgttgacgaa tcatcgctgg tgagccgact
    17401 atcaacgggt ccgagcaaac tcacgcacct gcgtggtgga aggggtagtc atgcagctca
    17461 ggttcctcgg caaagacaca caaggcggag gctcgccgac cctgtacgcc acggaccgcg
    17521 gtacctacgt ggtgcaggga tggaaagtgc acgggcatcc cacccggatc gagatccccc
    17581 accgcctgct cggacacgtc gaggaaggga aatgcctggg cgcccacctc gacgacacgg
    17641 gccgcggcag cttcatcctc tccggtcggc ccgtcaccga cgccgcagcg ctggcgacca
    17701 tggacatccc gggacacgaa acctgcgtcg aagtcccgac gaagaaggag gtacgggtca
    17761 gtgcaactgc tacagggtga ggcgttcgac gcgctcttcc gcgaattcga gcgcgacgcg
    17821 ttccacctgg aagtccggga cacctacacc acgccggagg agtcggaacc gttccacctg
    17881 ttcctgaccg gccgacacga cgacttcgca tggttccagc cgtggctgaa cctggtccgc
    17941 aacgccacca gcaccggccg catcgtacgg cgcgtccgcg tggtcaccgt cccgcacggc
    18001 gactacaccc ggtggggact caccgtggcc gaacacaaca ccgccgcagg cgaggacgtc
    18061 cggtggctac cccggcacct gatcaacccc gaccagctgt cggcggacga cttctggctc
    18121 ttcgacgaca accgcgtcgt gttcaccgtg ttcgaacccg acggccggtt cgccggcggc
    18181 gccgccacca ccgatcccgt catcgtgcgc cactgccgca cggtacgaga ccgggtctgg
    18241 cagaccgccg tcccgcacca ccgctacctg gagaccgagc acgccacggc ctgaaccgag
    18301 aacgagccac tcgtgacgca ctccctccac caggcacgcc aggccctcgg tcaccagctg
    18361 cgcgacctcc gcaaggacgc acaactcacc ggccgcgacc tggccaccct ggccggctgg
    18421 cacagctcca aagtctcaaa aatcgagtac ggcaaacaaa cccccaccga agacgacatc
    18481 cgggcctggt gccagcacac ccgttccgaa ccccaaatcc ccgacctcat cgccaccgta
    18541 cgcaacatcg aatccatgta cgtcgaatgg cgccgcatgc tcggagccgg cacccgacgc
    18601 cgccaaaaag cctcacaacg actcgaagcc aagaccacgc tgatgcgctg gtacgagccc
    18661 gtcctcatcc ccggcatcct gcaaaccgcc gaatacgccc acgaagtcat gcgccgcgtc
    18721 atcgaattct acgacatacc cgacgacctc gacgccggcg tcgccgagcg catggaacgc
    18781 cagaacatcc tctaccgcgg cgaccaccaa ttccacttca tcctcgccca gcaagccctg
    18841 acgacaaccg tcggcaaccc caacatcatg atcggccaac tcgaccggat cctggccatc
    18901 atgtcactac cacgagtcgt cctcggcatc atccccaacg acgccgaata ccgcgtaccc
    18961 accaaccagt tcatcatctt cgacaaccaa ctcgtccacg tcgaaaccat ctccgccgaa
    19021 ctcaccatca gtcaaccccg agaaatcgac acctacaaca aagccttcca atcactctcc
    19081 gggcaggccc tgacagggcc agcggcgcaa aacattatta ccagagcggt cgatcgattt
    19141 cataataaga gaaaataagt accggaaacg agtcaatttg tagcgggtgt caaggaatgc
    19201 gtcgaggata gtggggtaac gacggcctgt cgccgatccc tggttggcat cggttgctgc
    19261 cgcgtggagt ctttagcgat tggcggctgc tggtggtgtg gggcggatgg cgttgtagat
    19321 gtgtgcgact ttagcgccct tcgtaatcat gcgatcgagc gtgggcctca agctcacgcc
    19381 agccatcacc agtcgcgcta tgacagaacg tggccggccc atccttcggc gtgcggtgca
    19441 ggtcgtccta caaggtgacg ccggccgcgg gccagtcgag gaaacgctcg gcgaccgtct
    19501 gaccgtggta ggtctggccg atcgaggtga agcccagccg caggtagagc tgttcggggc
    19561 cgtcggggtg cggcacccac aggacagtga cccggttctg gccgcgtcgg cggggcctcg
    19621 atgcagggtt actcgtcagc gcaccggccg catccggtgc gctgacggcc agccgcgacc
    19681 gttgagtcgc cagatgccgc agcggaaata gtcgatcagg cagttcgggt cgaagccacc
    19741 cgtgatagac ccgacgagct gggtcgtcgt cgtagatcaa ccggggccat gcggaggtcg
    19801 gttgccggtg agccggagtt gggcgccggg gtgggggcgt tgccggcggg cgatgacccg
    19861 catgccgggt ggccagtcct gcggtccggg ccggctggcc gggtcggtgt gggcatccag
    19921 gcagtgagtt cggcgacctg cgcaccctcg cgcggtcggc cgccgttgtc gagggcggcg
    19981 cgccaggcct gcaccgggat ggtctccagt gcggtcttga cggtttcgtg cgcggggaac
    20041 ccgatcgagt attccacccc caggtcggcg agatgctgca gcagcgcttt ggagcaagcg
    20101 cccggagtcg gcgcggatga gcacgtgcgc tcgttcgcgc tcgggtagtt gggccagcgc
    20161 cagatcgacc gcctcaatgt gatcttgttt gttccacggt gaggcgtttc ccgggcgcag
    20221 ctgcgctacc agcgtttccc cggtcccgtg ttcaccgtgg tcgacgaagg cgcacatcgg
    20281 tgcgaacccg aatccccgct tgtgggtggg tgcggcctgt tccttgtccg aatgcgcggt
    20341 caccagtgtg gcgtcgatgt ccacgatcac ctggccacca tcctgggtgc cgggaccgcc
    20401 ggccagtggc cgtcgccgcg cccacaccgc cgcccgcgcc tgagcccggg cggaccggat
    20461 cgccggcacc gcgatcgcgc tgtcggcagc gagggtgctg aacaaccggg acaccgtcgg
    20521 gtcactggcc accaagccga acacctccgc ctgcgcccgg actaccgcga ggtcagccag
    20581 acaatctccg cccagagcga ccgcgatcgc gacatcacac acgatcttgc ccggatcatg
    20641 tgcggcgcgc cggcctcgcc acggcgcgag cgccccggac aacgcccgct gcgccccgga
    20701 caaccgcagc gtctgccgca gcagcaaccc accggcagac gacgccagcg actcgcgcgc
    20761 cggatcaaga acaacactcg ggcctgcggt acgcttctcc tacggagtgc cttccactcg
    20821 gtgctgcttg tgacgtcgca atcccaagca ttgccgggca ggacaggcac ttccgtgctt
    20881 ggcaggcccg tgtcgccacc caagacacga aatctcgagg cgtctggtgc tatcggcctc
    20941 acggcgggcg gcgcgttgca cctgggcagt agacacgggt cttggtccgg tggccggttg
    21001 cggtgaatga tcaccagcag acagacctcc atgtcggtgg gtggcgctac ggtcgatcca
    21061 gaaggtcgtc tgagaaggaa ggccctatgt cggtagacgc gtgccatgaa cgtgccagga
    21121 ggtacgaccg cggcttgcct cgcaagccta gctacgtcct cgtgacggtt aggcgccgta
    21181 gccgcacccg gtatcgcgac gtcagttcgg caggcgcgcg ctgcgaatgt ggtcgaagcg
    21241 gcggttcgtg gcagacgttg gtgaattggt cttcgacgac gaccacggcg tcacatcgtg
    21301 gggcagcttt gaatctacga agatttgatg agcatcgatg cggctctggt ctggagcgga
    21361 cagtacgtat ccaggcgccg ttgaacagcg tgaggaacgg agctttggca aacattcggt
    21421 acatcgaggg tgggaataat cgacttttgc ggcacgtcct gcggctcgtc tggggtcagc
    21481 aatgctattg gtgtcaccga tttaaggatt tctccgagct cgagattgat cacataatcc
    21541 ctaggtccat gagtagtggt gcacgaatca aattacaagg gaagttaaat ctgcccatgg
    21601 accatgatgt ccatgggatc tgtaatcttg ccccgatctg cggtgcgtgc aacaaggcga
    21661 agagtggtat ggatttatct gcgaccggtc ttctactgtc gatgttgcat aaagcgcgga
    21721 agctcgctcc cgagattact cggcaggtgg tagcgtttgg tagcccgtcc aagctcgaga
    21781 gtgccctcct tgaggcgacg gaggctgacc tgagcgatac aagaacgcga gagatcttcg
    21841 agcggagcgc gccggcagtc gttcaaaggc ttgctgaact cggggacgga aaagctgact
    21901 acttcgtgtt caaagaagtg agagtcgaag ctagtgagtc gccactgtac acctgtgggc
    21961 cacccgtcat ggtgagggtg gggctcaaac tgtacgaatg cggccgtgcc tcgatgactg
    22021 tcctcgagcg ggtggtcggt gggcggttgg aagtggcgct ccgtgtgccg ctatccgatt
    22081 tgttagaact tattgcgacg accgtaggga gtgcgttcga gagatatagc gaaaatccgg
    22141 acgcgtcgaa ggctggggaa gttaacattg aatggcccga gatcactatc gatcgcgttg
    22201 agttcgacag tcgttcgcca attgatcttg agttcgaatt tgcgggcgag tttcgggtgg
    22261 cggctacggc cggtgtcgct tgggtaagcc agcgtgacgg cagcttggaa gatgttcagg
    22321 gtgatgcaac cgtgagcggt cggttcaggt tcgaattgtc ttgggcgcct ggtgttgcaa
    22381 tcggtaagtt ccatttcggt caggtttggc ttgaagactg gcaagctgac gtatggataa
    22441 cgcccggacg cgagtcgttg cgatgtcaac tatccggatc ccactgacac agcgacgctg
    22501 gccgacgtcc cggcgtttcg cacctgctga tagacggtac tgaccgcgcc ggatgtgacg
    22561 gcgccagcgt acttgctgaa gtggcccact tccgaccagc ttcccgccac gttcttcacg
    22621 ccgacgtggc tgctgccaga aggcgacccg acacgacctt gggaggagat cctggatgtc
    22681 ctgttctgga aggttcacca gatcgagcac gcgacactcg cagctcgcct cgatcacgtc
    22741 gtggccttcc tcggtgtggg cgcagcgctc aagcaggaca tcggacgcca taccttccac
    22801 ttcgtcccgg tggcatgcga tcacgccatc gacctgtgcg atgcgttcct ccgtgacaaa
    22861 cccctgcccg ccgaatcatc gatcgtgacc gaggtcttgg aacgcctcgg gaaggcgatg
    22921 caaccagcga agagagcggc ccgcgacttc caacattgag agtgagcgta cggtatcgaa
    22981 cctggccagg ccgcatcggc gacttgagcc aggttcgtcc gcgcgcagta cgacaccgag
    23041 gccgggaagt acatcgcggc gttgataagc gacctgcccg caaccggctg gaccaatcgc
    23101 cgagcacatg gggccaccac accggatccg tgtaggacaa cggatccggc tgaacgggtg
    23161 attcgcccga cactcagccc ccgaccggct atcgtgacta ttcgtgccag acgatcatgc
    23221 acaccggggg ttccgcgcgc tcgttcccga acgtacctgg tcgacgctgt gcaagctcgg
    23281 tttcctccgc acttttagca agggtgagcc catcttcgta cgcggcgccc cggcgtcctc
    23341 ggttctgctg ctgacgtcag gacgggtcga agtggggtgc cacaccgagg acggcgacta
    23401 ccgcctcatc gccctgcgcg gcgccggtga tgtgatcggc gaggtggcct tcgaggtcgg
    23461 cggcgtgcgc acggcggacg tcttcgcatt ggaaccctgc gcggcttttg cagtgccctc
    23521 acacactttc gagcgcgtac tcgtcgccga cggcgtccac cgcgaggtcc gccggtatgt
    23581 agcggccaag ctgcaacggg cgggccagga ctcggtggac atgctgagcc tgcccccgtt
    23641 gcggcggatc gcacggttga tggtgcaact ggccgacctg gccgagccgg ggcacaaccc
    23701 tcgcctgata ccgatgtcgc agacccggct cgggcacgtg ttggggctgt cccgcagcct
    23761 cgtggctggc ctagtcgccc agctacgccg ggagggcgtc ctgagcgcgg agcgcaacct
    23821 gaccgtcgaa cggtttgaca agctccgccg ccacgcatac ctaagtcaag agtgacgcag
    23881 gtcacttttg ttcgtcttct ggtggacatc accccccggg ctgacgagcc acagtgcttc
    23941 ccatgaccga ggacacgcat tccgtcgcct atgagttgcc gccgtaccac gcggtgctgt
    24001 cggtggacgt caagaacttc agcggggtca cccccgccga ccattacgcg ctcaccgagc
    24061 tgatcccgac tatccttgaa cgcgcgttcg agcgggcgga gcacgccgcg acctgggcag
    24121 accgccggtt cccggccggt cgtggcgacg ggttcgtggt cggtttccgc ccggagagcc
    24181 tgccgatcct tgtcgggccg ttcctcgacg ccctgcagga cgaactggcc taccaccacc
    24241 gcatgcgcct cggccggaac ggcgagccga ctcgcctgcg ggtgagcgtc gcggtgggcc
    24301 cgctgaccga ttccgggaat gcccagctcg gggacggttc gggcgcggcc atggtcgaga
    24361 cacaccggct cctggactgc gagccggtcc gcgaactgct cgcaagctcc gaccccgagg
    24421 tcaccttcgt cgccgcggtg ctctcggcgc gcgtctacga ggacgttgtg ctctccgggt
    24481 acgcggcgaa ggcaccgggt gagttcgtcc gtgtcccggt gtcggtgaag agttacgtgg
    24541 gtgatgccta cctgcacgtg ccgaaaccct cgggtgacct gctgtcccgg ggcatcggca
    24601 cgccggacga gccattcccc gacggccccg tttcgcagga cgaagctccc ggagccaata
    24661 gcgcggtggc caacacgagc aacggcaccg tatacgggaa cacgatccaa atgcgggacg
    24721 agtatcgccg gaccgacaaa tcccggaact cgcaccagca caccgtcggc gacgggaaca
    24781 tcgtcaccgg cggcaaccta cgcggcggta tccgacagaa cgtccgcaag aacggggaga
    24841 agaactgatg accaccacgg acagcttcaa ggcccccacc agtagcacct cggtcaccgg
    24901 cgatggcaac gtgaccgtgg gtggctacgt caccggcggc atttccgtcg acgtgcggaa
    24961 atcgggtgac acggtccagg tcttcggcac cggcagcggg taccgggacc tgatcgtccg
    25021 ggacgagatc gaccctggcc accttctctg gcttaaggac cgtttcgccg agccgcacga
    25081 gttcaccgag atcgtgaagt ccttgcatga cgacaaggtc gtcttcctcc acggccggcc
    25141 gcgcagcggg cggtggacga ccggcgtctg ggcgctcagg gccgtttccg gcggcgaaac
    25201 gccgacgatc aacgtcatcg agttcgacga ggacacccag ctcgacttgc gccgcgtcgc
    25261 gcagaacgcc cgcatcctgc ttgacctgac caagaccgac agcgaggtgc tcgacaaagg
    25321 cgaaagccag ctcaagagct tcctgggtac cgtcacgggc gcggaagcac atctcgtcgt
    25381 gctcctgccc gaaccgccgc cgcctgcact gcaagcgctc taccagggcc ggaccaagca
    25441 act
//
