LOCUS       NZ_CP076538            22562 bp    DNA     circular CON 16-DEC-2024
DEFINITION  Amycolatopsis aidingensis strain YIM 96748 chromosome, complete
            genome.
ACCESSION   NZ_CP076538
VERSION     NZ_CP076538.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis aidingensis
  ORGANISM  Amycolatopsis aidingensis
            Bacteria; Bacillati; Actinomycetota; Actinomycetes;
            Pseudonocardiales; Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     YIM 96748 draft genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7657695)
  AUTHORS   Li,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (08-JUN-2021) Yunnan University, Yunnan Institute of
            Microbiology, 121 Street, Yunnan 650000, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdevono v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 57.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018885265.1-RS_2024_12_16
            Annotation Date                   :: 12/16/2024 14:59:15
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,118
            CDSs (total)                      :: 7,060
            Genes (coding)                    :: 6,941
            CDSs (with protein)               :: 6,941
            Genes (RNA)                       :: 58
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 49
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 119
            CDSs (without protein)            :: 119
            Pseudo Genes (ambiguous residues) :: 0 of 119
            Pseudo Genes (frameshifted)       :: 44 of 119
            Pseudo Genes (incomplete)         :: 87 of 119
            Pseudo Genes (internal stop)      :: 2 of 119
            Pseudo Genes (multiple problems)  :: 13 of 119
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 14:56:56
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3586435
            Orig. end                         :: 3608997
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP076538.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22562
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="18"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22562
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22562
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12562](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12562
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(192..210)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.82"
                     /tool="antismash"
     gene            complement(621..2090)
                     /locus_tag="KOI47_RS16390"
     CDS             complement(621..2090)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014218.5"
                     /locus_tag="KOI47_RS16390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytosine permease"
                     /protein_id="WP_216216806.1"
                     /transl_table=11
                     /translation="MVTPANHSPAAGPAPPAAGRASGHAGEFTELPVLRHERIWGFWQF
                     TSVNVGLAIATWAFLTGGTIAMFAGVRTAIAATVIGNLVGVVLMAAATCLPSAKYGVEQ
                     YTALRTVFGLNGVRTLIAVMMPFAQAGWNAVLAVMFGRAVTNVLNSVFGTTFAPDSWMV
                     VAMSLLALVLAWLIVARGPVSIEWVNKIVAPLLAVLTVVMLIALLRAHSWTELNAAQPV
                     AALGDDRLNFTLALELSFATGFSWWTIMGNLARLTTTPRTAFWPNMIGLFAASVVAGLI
                     GTFAALALGEIDPTMWMVPLGGVLLGVLALLFIAVANVTSMVAQTYSGALAVIRAGGSA
                     VRRLPWPLFVALMFLPSAVVVFWPTALYDNFFKFIAWVGLVMAPLTAVYLVDFALLRGR
                     TLWLRDLYEPEGVSRYSFWWGFNPAAFLAVAAGAVTYSLLLNPVTFSSAGVFTYTSASL
                     PAFLVTAAVHTVLTLAWVRPAGKGGYREEAP"
     gene            complement(2084..2254)
                     /locus_tag="KOI47_RS16395"
     CDS             complement(2084..2254)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216807.1"
                     /transl_table=11
                     /translation="MDNAEFRRELDRRLDLLADPSYPDPARAGLPSRDLTVLAVLAVGL
                     ITALLAWGYPW"
     gene            complement(2256..3209)
                     /locus_tag="KOI47_RS16400"
     CDS             complement(2256..3209)
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498578.1"
                     /locus_tag="KOI47_RS16400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_216216808.1"
                     /transl_table=11
                     /translation="MRLSTAGIPGSPARVTEPTRRPLVVGLVQTRWHADHVEHEAVLLD
                     GIRTAAGARAQVVFLPELTLSRYPADRRPGTGAATATAEELETGPTFTFAAKAAADTGV
                     AVHASLYERADGPDGLGYNTAILVSPEGRLLGRTRKLHIPVSAGYYEDHYFRGGPAGPD
                     PYPVVELPAAEGGPAARLGLPTCWDQWFPEVARAYSLAGAEVLAYPTAIGSEPDHPGFD
                     TQPLWRQVIVGNGIANGTFMVVPNRWGEEGTLTFYGSSFISDPYGRVLASAPRDADTVL
                     VAPLDLDQRRDWLTLFPFLDTRRPDTYTSLTRPIGG"
     gene            complement(3200..4267)
                     /locus_tag="KOI47_RS16405"
     CDS             complement(3200..4267)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498579.1"
                     /locus_tag="KOI47_RS16405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="agmatine/peptidylarginine deiminase"
                     /protein_id="WP_232376778.1"
                     /transl_table=11
                     /translation="MTTAQPSMPAEWAPHERTWMAFPPPNGTFGEPDSPALAAARRSWA
                     RVANTIAAYEPVTMVAGAGQGATAAALLRPDVDVLEIPLDDAWMRDIGPSFVHEDSAHT
                     GLAAVDWAFNGWGGQGWAGWARDDRVAATVAGLAGYPVRRSALTMEGGGFQVDGEGTVL
                     LTETVQLDPGRNPGWTREQVEAEIHARLGTTTAIWLPRGLTRDYQAYGTRGHVDLVACF
                     LRPGVVAVHTQTDPAHPDFTVCREIADILRSSTDAGGRRLRVVELLAPEESFDPGGEPV
                     DYSYVNHYLANDVLVLGAFGDPRDAAAAEVLGRAFPGRAVEFVDARGIFAHGGGIHCIT
                     QQQPAARRRGAPPCD"
     gene            complement(4273..5709)
                     /locus_tag="KOI47_RS16410"
     CDS             complement(4273..5709)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098512.1"
                     /locus_tag="KOI47_RS16410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gamma-aminobutyraldehyde dehydrogenase"
                     /protein_id="WP_216216809.1"
                     /sec_met_domain="Aldedh (E-value: 5.9e-154, bitscore:
                     511.7, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKQTFRNLVNGRHTDSAEGRTLDLVDPATGTVYATSALSGKSD
                     VDQACTAAATAFEGWRDSTPAGRQRALLRIADALESRTEEFVRCESANTGKPLALTRSE
                     ELPMAIDQLRFFAGAARVLEGTAATEYLPGLTSFVRREPIGVCAQVTPWNYPLMMAIWK
                     IAPALAAGNTVVLKPSDTTPASTVLLAELAAEFLPPGVLNVICGDRDTGRELAAHRIPQ
                     QVSITGSVRAGIEVAGAAAADVKRVHLELGGKAPVVVFADADIEAAAGAIAEAGYFNAG
                     QDCTAATRVLAAAGVHDDFLAALTEKARAVRTGPPAEPDVAYGPLNNATQLARVAGFVD
                     RLPGHAELHTGGTRVGERGFCYAPTVVSGLRPGDEIVRDEVFGPVITVQRFTGEEEAVR
                     LANDVEYGLASSVWTRDHARAMRMSRRLDFGCVWINTHIPLAAEMPHGGFKHSGYGKDL
                     SLYGLADYTRVKHVMTSIEG"
     misc_feature    complement(5861..5875)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            5928..6413
                     /locus_tag="KOI47_RS16415"
     CDS             5928..6413
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019510115.1"
                     /locus_tag="KOI47_RS16415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_232376779.1"
                     /transl_table=11
                     /translation="MNRKNPAAERSSATLLDDTSKRIIEHLQQDGRRPYSTIGQAVGLS
                     EAAVRQRVQRLSDAGVIQIVAVSDPMQVGLFRQAMIAINVDGPLEPVADALAELAEIDY
                     VIICAGRFDVLCEAVCEDDAALLDLISNRIRTLPGVRNAETLMYLKLRKQSYQWGTR"
     gene            6586..7977
                     /locus_tag="KOI47_RS16420"
     CDS             6586..7977
                     /GO_function="GO:0008483 - transaminase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (39-390). E-value: 5.5e-92.
                     Score: 300.3. Matches aSDomain:
                     nrpspksdomains_KOI47_RS16420_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639022.1"
                     /locus_tag="KOI47_RS16420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_216216811.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.8e-89, bitscore:
                     298.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTAASTPAEPDGLARSAGEHLWLHFTRHSGFADARIPVIVRGE
                     GAYLWDSGGKRYLDGLASLFAVQVGHGREELAEAAARQIRQLAYFPLWGQAHPTAIELA
                     ERLACAAPGDLNRVFFTVSGGESVETAWKLAKQYFKVTGKPTKHKVISRSLAYHGTSHG
                     ALSITGIPAAKQDFEPLVPSGLRVPNTNFYRAPEHGDDYQAFGRWAADQIAQAIEFEGP
                     DTVAAVFLEPVQNTGGCFPPPPGYFRRVREICDQHDVLLVSDEVICAFGRLGHEFGAAR
                     YGYQPDLITTAKGLTSGYAPLGAVLAGERLMEPFRHGTTTFMHGSTYGGHPVSCAVAMA
                     NLDLLEREHLYEHVLAKEGLFKSTLDELTDLPIVGNVRGAGFFYGIELVKDKAGKETFT
                     AEESERVLRGHLSSALFEAGLYCRADDRAEPVIQLAPPLICDRPQFDEIGQILRDALTE
                     AWKIL"
     aSDomain        6703..7755
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KOI47_RS16420_Aminotran_3.1"
                     /evalue="5.50E-92"
                     /label="KOI47_RS16420_Aminotran_3.1"
                     /locus_tag="KOI47_RS16420"
                     /protein_end="390"
                     /protein_start="39"
                     /score="300.3"
                     /tool="antismash"
                     /translation="VIVRGEGAYLWDSGGKRYLDGLASLFAVQVGHGREELAEAAARQI
                     RQLAYFPLWGQAHPTAIELAERLACAAPGDLNRVFFTVSGGESVETAWKLAKQYFKVTG
                     KPTKHKVISRSLAYHGTSHGALSITGIPAAKQDFEPLVPSGLRVPNTNFYRAPEHGDDY
                     QAFGRWAADQIAQAIEFEGPDTVAAVFLEPVQNTGGCFPPPPGYFRRVREICDQHDVLL
                     VSDEVICAFGRLGHEFGAARYGYQPDLITTAKGLTSGYAPLGAVLAGERLMEPFRHGTT
                     TFMHGSTYGGHPVSCAVAMANLDLLEREHLYEHVLAKEGLFKSTLDELTDLPIVGNVRG
                     AGFFYGIELVK"
     gene            complement(8015..8374)
                     /locus_tag="KOI47_RS16425"
     CDS             complement(8015..8374)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216812.1"
                     /transl_table=11
                     /translation="MRLCYGLVLAAIACGIGAVGVLSAPVTPSGPAARSVTACGTALER
                     SVGFDRLLGADRPWTGATKRFVSREVWEQIVDCRNARARHQALGYTLAGGGTLLALLAF
                     SECRGAKRTRRREGG"
     gene            complement(8410..8772)
                     /locus_tag="KOI47_RS16430"
     CDS             complement(8410..8772)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949372.1"
                     /locus_tag="KOI47_RS16430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MmcQ/YjbR family DNA-binding protein"
                     /protein_id="WP_216216813.1"
                     /transl_table=11
                     /translation="MGVSDDQFLRMVRDLAEVTSAKARDYTSFSVRGKRFGYHWPRTST
                     VGLKQLLSEQVALVAERPEVFEVQFTAGGFGWVVVHLPEIDADELGELLYEAWRLSAPD
                     ALAEEHPLPSTSANPA"
     misc_feature    complement(8747..8761)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.52"
                     /tool="antismash"
     misc_feature    8770..8785
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.15"
                     /tool="antismash"
     misc_feature    9046..9060
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 20.98"
                     /tool="antismash"
     misc_feature    complement(9050..9064)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.5"
                     /tool="antismash"
     gene            9168..9845
                     /locus_tag="KOI47_RS16435"
     CDS             9168..9845
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015649.5"
                     /locus_tag="KOI47_RS16435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_216216814.1"
                     /transl_table=11
                     /translation="MLLATLALRVGKPVERDELITAIWPDDPPPSAQATLRGYVKRLRR
                     VLMTGAGEEISAVRATDGGYVLCLPEDNVDLVRFRRLVALAAVRRDVYGELPLLQRALA
                     LWRGPAFVDVSSPALRPGVVNTLHEEYLRAREREVEIRLRLGQYGWLIPELAALVADNP
                     LRETLWYQLVLALHLNGRQAEALAHYESLRELLADSLGTDPSPLMRDLHQRILSGKPMR
                     TAC"
     misc_feature    9657..9659
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..11827
                     /locus_tag="KOI47_RS16440"
     CDS             10001..11827
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="KOI47_RS16440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_216216815.1"
                     /sec_met_domain="Asn_synthase (E-value: 4e-31, bitscore:
                     107.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVEAGWHFVTLPDHDEAKVVLRRLDASAYRVLNHPSGRPWLLTT
                     TPRDQLVAHAEGPNRIAVLGWSSATVRRLAAAASGHELSALDDLAHELSGGFHLVASFE
                     GRVRAQGSASGLRRVWHAEIDGVHIASDRADVLAELGGHPLDEVAVAIRLLRVLPHPAA
                     EQPLWQGIRPVPPDSYLRLDRERGRTPSLVRWWRRPEPELTRAQGAERLRGALEDAVAA
                     RVRDGLTMHCDLSGGLDSTPLCYLAGRMTAPLLASTAYNDDPGAGEDLRWARRALSAMP
                     SVRHEVLSLDDMPDFFGGIPELRARADEPTGAQLAMPRVGYRIEHARARGADTYLTGLG
                     GDHLLRGVPVWEHTLFRRHPVLALRRVWANQMLEGRPMRTTVRALLANESYRSWFRRSV
                     RTGEYAHMFTGTPTLDWDIPLSWPTWLRPEARDAVRSRLTAIAVDVEPLGPDRASHSEL
                     AKIRDGARLVRGLQQYAGTIGMPFEAPFFDDRVIEACLSVRRHERVHPKEYKPLVKAAM
                     RGALPDDFLRRNGKTGGSAQAARGLRGHFDELVEFCARSPLAGLGLIDIDRLRREAVPS
                     WSRPRDRNFDSTVNCAAFLHTTARRSAADTAA"
     gene            11844..12101
                     /locus_tag="KOI47_RS16445"
     CDS             11844..12101
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033530.1"
                     /locus_tag="KOI47_RS16445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_216216816.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.3e-20,
                     bitscore: 71.9, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.7e-17, bitscore: 61.5,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIRLNDDVSSVRTDYGMVLLDENTGRYYELSETAACVVDHLDGE
                     HSEDRAVDALTGRFEVTDQRARADVRALVARLESAGLVTT"
     aSDomain        11847..12095
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KOI47_RS16445_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.00E-23"
                     /identifier="RREFam002.1"
                     /label="KOI47_RS16445"
                     /locus_tag="KOI47_RS16445"
                     /protein_end="84"
                     /protein_start="1"
                     /score="71.9"
                     /tool="antismash"
                     /translation="PIRLNDDVSSVRTDYGMVLLDENTGRYYELSETAACVVDHLDGEH
                     SEDRAVDALTGRFEVTDQRARADVRALVARLESAGLVT"
     gene            12098..12562
                     /locus_tag="KOI47_RS16450"
     CDS             12098..12562
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005163726.1"
                     /locus_tag="KOI47_RS16450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_216216817.1"
                     /sec_met_domain="PF13471 (E-value: 1.3e-26, bitscore: 91.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPVLPDTLVRVSIARRVLTWGVVGVARALARRPPRQLRRALER
                     ASRGARPATHTEAKAARDTVLTVSTRCCGPEACLPRSIAAALLCRLDGSWPTWCAGVLP
                     TPPFAAHAWIEVDGELVDEPVEPGYYRTLVRVPRAARKGLAGHGQEQETQ"
     gene            12588..12731
                     /locus_tag="KOI47_RS16455"
     CDS             12588..12731
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_216216818.1"
                     /transl_table=11
                     /translation="MQRTAYETPTVVELGVFAEETGLDAPQNNEEVIGIGDDWIPPFAP
                     KN"
     gene            12838..14538
                     /locus_tag="KOI47_RS16460"
     CDS             12838..14538
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="KOI47_RS16460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_216216819.1"
                     /transl_table=11
                     /translation="MRPADRLLCRTLLATRVTGILLVAAGVVDAATRIAIPAVLGAALD
                     EVLGGAGPLSPASSLLLALLLVAVLAEPAREYLARRCELLGMKELRDRSSRHAISLGAQ
                     SRFAPADSQARLLESTAEAARVSTAGLTLLTSVCTSVAGLVALVLIDLPVALVFLCGAP
                     LVWWLTRWLIGRVGRMTGRYQRAHADLAERFLDALTGIRTIRASGTAEREIGRILGTLG
                     ELRETGHDYWETQRRAGWQLGLLTPLLAVAALSVAGLGLLAGRLSAGELVAVSSYLTYA
                     LGLLRQASVLAKFARARGSAERLSELLAQPVPPEGYLPAPVGALTVRLRGVSACHGHRR
                     VLGEVNLDIPAGSSVAVLGSDGAAASLLAEVVAGLRIPDQGAVLVNGVAQSAFDSRALR
                     ERVGFAFARPHLLGNTVADAVAYTDEPPAPDRVETALDTAAARPFVDRLPEGAATPLPG
                     LRLSGGETQRLGIARAVCRDVGLLVLDDALSSVDTVTESTITEALRTVAPGATRLIVTH
                     RATTADAADLVVWLDGGQVRATGPHRELLNQAGYAALFGSGQPQREAAS"
     misc_feature    13327..13329
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14179..14181
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    14203..14205
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14646..>15350
                     /locus_tag="KOI47_RS35640"
                     /pseudo=""
     CDS             14646..>15350
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="KOI47_RS35640"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter transmembrane domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDVGFLAGSAVNGLLLLGSYGAVIALGSFATRQAIRPMSVIVEAV
                     RDHLVRSVVRGTLHTAVREDRPAESGSVARLTRQTEQVRQLLAGLLMALRTVAFSLVAA
                     MVGLLTLAPLVGIMTVPALVACGLVVASLSREWRKRYADSLACEEQLSGRLAAVLPALR
                     DVHACAAAGRTTGEVTADIATHVRTARGAAVIGAARVGVVSLSARMPLVALLLAAPWLV
                     SSGALSTGEVVGA"
     misc_feature    14901..14903
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15481..15500)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            15611..16216
                     /locus_tag="KOI47_RS35645"
     CDS             15611..16216
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="KOI47_RS35645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_232376781.1"
                     /transl_table=11
                     /translation="MGPSGIGKSTLASVLCGAIEPDGGKVSLGGTPLHRLEPGALRRSV
                     VLVPQEAYLFRGSVRDNLSYHRDDHPDDMTITGAVTAVGAQELLSSLGGLGAELLPRTL
                     SAGERQLLVLARVYLGSAEVVVLDEATCHLDETTEARAEQAFRSRGCTLVVIAHRISSA
                     RRAQRVLVLDGTGVRDGSHAALVANSDTYAELVGHWST"
     gene            16242..17384
                     /locus_tag="KOI47_RS16475"
     CDS             16242..17384
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="sensor histidine kinase"
                     /protein_id="WP_216216821.1"
                     /transl_table=11
                     /translation="MPMPHLPAPGSAGLAEREVSGFAARYARLVRFVVVSLCGGVGVLA
                     VPVGGMAGTALIVAAMITWSGWLLRRRARPTAPVVVADLVLLAGVCLSQPLTVGPEPVS
                     HGNTWVCGVISIALVTYQWCYPPLPGLTIAALLVPIDMVGVALADPHGWTADLGLGAWM
                     LVEAVLSQALYQAIRRRARDWDRKAEEVAEARRQARVSEVRHRAEREHLAVLHDTACAT
                     LLMASIPGSDVAEVRAQARRDLDTLTRTEDTTTDTELGTALSAEAEEHAVAVTVTADGQ
                     VWLPATVASALRASSGEALRNVARHAGVPEATVRVEQDGCGTVAVEIVDTGRGFDPDSV
                     PAPRNGIRYSIQERMRAVVGRADIRSRPGHTSVRLEWPDG"
     gene            17377..18510
                     /locus_tag="KOI47_RS16480"
     CDS             17377..18510
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216822.1"
                     /transl_table=11
                     /translation="MADPSTPPPGGRVLNGARLATFGVLVAVHFGLSLPALVSSWDVYV
                     DADQAAVGYAALTANVGLIGWFVLRGRSQPAWAVRTGLVVAIAASVLLTAQVPGDQLVR
                     QAHWTFPELGWHGVMLLIERPFVHACAFLATHLVLTAIQAILIEPPDRIAASGMLITSV
                     ITCGLQLAMSWGIKVLRRYLARADAAARERDRVLTENAVSVQLRLDRRRRDADHAADVL
                     TVLRGLADGSLDPDDERTRRLCAVRAATLRRLFAENETSSDRLLHELRAGIDVAERGGV
                     TVQLAVRGTPRSLPIRVRRALTDVAIAGIAAARRTARVTVIHAGQVRVSVVTDAPDIEL
                     PSGADAGVAASATHNGGKLWVEARYPVHRSSSATSPS"
     misc_feature    17476..17478
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(18477..19127)
                     /locus_tag="KOI47_RS16485"
     CDS             complement(18477..19127)
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015101434.1"
                     /locus_tag="KOI47_RS16485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_216216823.1"
                     /transl_table=11
                     /translation="MGRPVTVSVIDDHPVVLAGVRSWYSQAIPPISVVAEGTTMGVAMT
                     PPGNAADVVVLDLRLGPAASVFHDLRTLVEADRQVIVYTMRDDQQTALNCLELGAFTYL
                     TKAEGAEHLVPATRAAASGCPYTPPALAGAFAGNTAPDRPALTPREAEVLIEWFQSESK
                     AMVAESLGLSTRTVSSYLDRVRVKYANVGRPAATKANLVARAIQDGLVALDDL"
     misc_feature    complement(19180..19193)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.14"
                     /tool="antismash"
     gene            19335..19595
                     /locus_tag="KOI47_RS16490"
     CDS             19335..19595
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216824.1"
                     /transl_table=11
                     /translation="MGWLVRWDGAAGIRKTTLAVQWEHRVQDRLPDGTLQVSLRGHELG
                     DPATPGEVLEGFLWALGVAAGRIPGARRGYPAPVRHCRRGG"
     gene            complement(19604..19819)
                     /locus_tag="KOI47_RS16495"
     CDS             complement(19604..19819)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS16495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_216216825.1"
                     /transl_table=11
                     /translation="MRNERVPSELLADITDEFAHQVRAIQTYPVREIYTMISAGRPAEV
                     GLRGYPAVQTTTAAGNYRRGRERSAQ"
     gene            complement(20134..20448)
                     /locus_tag="KOI47_RS16500"
     CDS             complement(20134..20448)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657591.1"
                     /locus_tag="KOI47_RS16500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_216216826.1"
                     /transl_table=11
                     /translation="MADLPTNPTVRAFVTAINTGDRDAFDSLLAPGAAMSDDGTDRNLD
                     SWVDQEIFSAEGRMDVESESDDGRALIARFTNSSWGTMRTRWHFTINDGTITRFDTGQA
                     "
     gene            complement(20536..20679)
                     /locus_tag="KOI47_RS35650"
     CDS             complement(20536..20679)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS35650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_232376782.1"
                     /transl_table=11
                     /translation="MEFHKSQTLGNRLTQIEDIVPSVGFLATDGRWITGRTIFTNGGYT
                     TR"
     gene            complement(21059..21313)
                     /locus_tag="KOI47_RS35655"
     CDS             complement(21059..21313)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KOI47_RS35655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_232376974.1"
                     /transl_table=11
                     /translation="MSRTQPGGVTTFFGVVIPVSAILVSAPAIAGITTKPDAVTTVRTN
                     ALNLINPPLPRTESPTKQHAKQLAHSIYDRPVTRNIGFN"
     gene            21219..21857
                     /locus_tag="KOI47_RS16510"
     CDS             21219..21857
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005449601.1"
                     /locus_tag="KOI47_RS16510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="C39 family peptidase"
                     /protein_id="WP_232376783.1"
                     /transl_table=11
                     /translation="MPAMAGAETRIADTGITTPKNVVTPPGWVRDMPAPATVGDVGTAA
                     VLDIQYQVQQTGYWCGPAATRIAISARRSNPPSQATLAAQLPTTTNGTDWIGQVTRVLN
                     QNLGTGWYETKEMPNDPPTQAQRDLLWRDIVLDINNGYAIVANIVAPPSNHPPGYPNYT
                     VYHYFTVIGYDSSDMTVKIADPANFGGNKIYWLTFNQLATLIPPKGYSA"
ORIGIN
        1 gtgccggtcc cggtcggcat cggtggcggt ctcggcgagg aacttccagg cgagctgttg
       61 tgccgcggtc tcctcgaggt gcccggtcgg ttcaccggtg accgggtcgc ggacgatccg
      121 gccgcccggc gggtcgggcg tgtgccgggt gatacccagt tcggtcagcg cggcgctgtt
      181 gagccatacc gagtgatagt cgttcgcgtc gaggtacgcg ggccgatccg ggatcatctc
      241 gtcgagcagc gcccggtgcg gcctgccgcc cggaacggcc gagaacagcc agccacggcc
      301 gagaacccgc ggggcaccgg gattggcctc ggcccactcg cgcaggcgct gccggatgcg
      361 ctgcgggtcc ccggcgtcgg tgagaggcgc ccgcagcccc gcctcaccgg tcgccaggac
      421 atgcgcgtgc ccgtccacga aaccgggcag caccgtcctt cccccgaggt ccacccgggg
      481 accagcggtg ccgcgggccg ccgcgtcggc gtccgagccg acgaactcga tccggccgtc
      541 gcgggtgacg atcgactcgg cccacggcat cgaggcggcg ccggtgaaca ccctgccgcc
      601 ggagtaccac acgtgatcac tcatggcgcc tcctcccgat agccaccctt gccagcaggc
      661 cgcacccacg ccagcgtcag cacggtgtgc accgcggccg tgaccaggaa ggcgggcagc
      721 gatgccgagg tgtaggtgaa tacgcccgcc gaggagaacg tcaccgggtt gagcagcagc
      781 gagtaggtca ccgcaccggc cgcgaccgcg aggaacgccg ccgggttgaa accccaccag
      841 aacgagtacc gggagacgcc ctcgggctcg tacaggtcgc gcagccacag ggttcgcccg
      901 cgcagcagcg cgaagtccac caggtacacc gcggtcagcg gggccatgac cagtccgacc
      961 caggcgatga acttgaagaa gttgtcgtag agggccgtcg gccagaacac cacgacggcc
     1021 gatggcagga acatcagcgc cacgaacagc ggccagggga gccggcgcac ggccgacccg
     1081 cccgccctga tcacggcgag cgcgcccgag taggtctgcg ccaccatgct cgtgacgttg
     1141 gcgaccgcga tgaacagcag cgccagcacc ccgagcagca ccccgcccag cggcaccatc
     1201 cacattgtcg ggtcgatctc gccgagcgcg agcgcggcga acgtgccgat cagaccggcc
     1261 accaccgatg cggcgaagag gccgatcatg ttgggccaga acgccgtgcg cggggtggtg
     1321 gtcagccggg cgaggttgcc cataatcgtc caccaggaga atccggtcgc gaagctcagt
     1381 tccagcgcga gggtgaagtt caaccggtcg tcgccgagcg ccgccacggg ctgggcggcg
     1441 ttcagctcgg tccaggaatg ggcgcgtagc aacgcgatca gcatgaccac ggtcagcacg
     1501 gccagcagcg gagcgacgat cttgttgacc cattcgatcg agaccggacc gcgcgccacg
     1561 atcagccagg ccagcaccag cgccagcaac gacatggcga cgaccatcca gctgtcgggg
     1621 gcgaaggtgg taccgaatac cgagttcagc acgttggtga ccgcgcgccc gaacatgacc
     1681 gccagcaccg cgttccagcc cgcctgcgcg aacggcatca tgacggcgat cagcgtgcgc
     1741 accccgttca gcccgaaaac cgtccgcagg gcggtgtact gctcgacgcc gtacttggcc
     1801 gatggcaggc aggtcgccgc ggccatcagg acgacgccca ccaggttgcc gatgacggta
     1861 gcggcgatgg cggtcctgac cccggcgaac atcgcgatcg tgccgccggt gaggaaggcc
     1921 caggtggcga tcgccagccc gacgttgacc gaggtgaact gccagaaacc ccagatgcgc
     1981 tcgtgccgca gcaccggaag ctcggtgaac tcgcccgcgt gcccggaagc ccgccctgcg
     2041 gcgggtggcg cgggaccggc ggcgggggag tggttcgccg gcgttaccac gggtagcccc
     2101 aggccagcag ggcggtgatg agccctacgg ccagcacggc cagcacggtg aggtcgcggc
     2161 tgggcaggcc ggccctcgcc gggtccggat aggacgggtc ggccagcagg tcgagcctgc
     2221 ggtcgagttc tcggcggaac tccgcgttgt ccatctcagc ctccgatcgg ccgggtgagc
     2281 gaggtgtagg tgtcgggtcg gcgggtgtcc aggaacggga acagggtgag ccagtcccgc
     2341 cgttggtcga ggtcgagcgg cgcgaccagc accgtgtcgg cgtcccgcgg agccgaggcg
     2401 agcacccgcc cgtaggggtc ggagatgaag gacgagccgt agaaggtgag cgttccctcc
     2461 tcgccccacc ggttggggac gaccatgaac gtgccgttgg cgatcccgtt tccgacgatg
     2521 acctgccgcc acagcggctg cgtgtcgaag ccggggtggt cgggctcgga gccgatcgcg
     2581 gtcgggtagg cgagcacctc ggcaccggcg agcgagtagg ccctggcgac ctcggggaac
     2641 cactggtccc agcaggtcgg caggccgagc cgggcggcgg gcccgccctc ggccgcgggc
     2701 agctccacca ccgggtaggg gtccggcccg gctggcccgc cgcggaagta gtggtcctcg
     2761 tagtagcccg cggagacggg gatatgcagt ttccgggtcc tgccgagcag ccgcccctcc
     2821 ggggagacca ggatggcggt gttgtacccg agcccgtccg gaccgtccgc ccgttcgtac
     2881 aacgaggcgt gcaccgcgac cccggtgtcg gcggcggcct tcgcggcgaa ggtgaacgtc
     2941 ggcccggtct ccagctcctc cgcggtggcc gtcgcggcgc cggtgccggg gcggcggtcg
     3001 gcgggatagc gggagagcgt gagctcgggc aggaacacca cctgtgccct ggccccggcg
     3061 gcggtgcgga tgccgtcgag caggacggcc tcgtgctcga cgtggtcggc gtgccagcgg
     3121 gtctgcacga ggccgacgac cagtggcctg cgcgtcggtt cggtgacccg cgccggcgat
     3181 ccgggaatcc cggctgtgct cagtcgcatg gtggagctcc tcggcgtcgt gcggcgggct
     3241 gctgctgggt gatgcagtgg atgccgccgc cgtgggcgaa gatgccgcgc gcgtcgacga
     3301 actccacggc gcggccgggg aaggcgcggc cgagtacctc cgccgccgcg gcgtcccgcg
     3361 ggtcgccgaa ggcgccgagc acgaggacgt cgttggcgag atagtggttg acgtaggagt
     3421 agtcgacggg ctcgccaccg gggtcgaagc tctcctcggg cgcgaggagt tccaccaccc
     3481 gcagccgcct gcccccggcg tcggtgctcg accgcaggat gtccgcgatc tcccggcata
     3541 ccgtgaagtc gggatgcgcc ggatcggtct gggtgtgcac cgcgacgacc cccggccgca
     3601 ggaagcaggc caccaggtcg acgtgtcccc gggtgccgta ggcctggtag tcgcgggtga
     3661 gaccgcgcgg cagccagatc gcggtggtgg tcccgagccg ggcgtgtatc tcggcctcca
     3721 cctgctcgcg ggtccagccc ggattgcggc cgggatcgag ctggacggtc tcggtgagca
     3781 gcacggtgcc ctcgccgtcg acctggaacc caccaccttc catggtgagc gccgaccgcc
     3841 gcaccgggta ccccgccagg ccggccacgg tggcggcgac gcggtcgtcc ctggcccagc
     3901 cggcccagcc ctggccgccc cagccgttga acgcccagtc cacggcggcc agcccggtgt
     3961 gcgccgagtc ctcgtgcacg aagctgggtc cgatatcgcg catccacgcg tcgtcgagcg
     4021 gaatctccag gacatcgaca tcggggcgca ggagtgccgc ggcggtcgcg ccctgcccgg
     4081 ctccggcgac catggtgacc ggttcgtagg cggcgatggt gttggcgacc cgcgcccagc
     4141 tccgcctggc cgcggcgagc gcgggcgagt ccggttcgcc gaaggtgccg ttcggcgggg
     4201 gaaacgccat ccaggtccgt tcgtgcgggg cccattcggc aggcatcgag ggctgggcgg
     4261 tggtcaccgg cctcacccct cgatactggt catgacgtgc ttgacccggg tgtagtccgc
     4321 caggccgtac agggagagat ccttgccgta gccggagtgc ttgaagccgc cgtgcggcat
     4381 ctcggcggcg agcgggatgt gcgtgttgat ccagacgcag ccgaagtcca gccgccggga
     4441 catccgcatc gccctggcgt gatcgcgggt ccacactgag gaggccagcc cgtactcgac
     4501 gtcgttggcc agccgcaccg cctcctcctc gccggtgaac cgttgcacgg tgatgaccgg
     4561 cccgaacacc tcgtcccgga cgatctcgtc ccccggacgc agtccggaga ccaccgtcgg
     4621 cgcgtagcag aaaccgcgtt cgcccacccg cgtgccaccg gtgtgcagct cggcgtggcc
     4681 gggcaggcgg tcgacgaacc cggcgaccct ggcgagctgg gtggcgttgt tcaacgggcc
     4741 gtaggcgacg tccggctcgg cgggcggccc ggtgcgtacc gcccgtgcct tctcggtgag
     4801 cgcagccagg aagtcgtcgt gcacacccgc cgccgccagt accctggtgg ccgcggtgca
     4861 gtcctggccc gcgttgaagt accccgcctc ggcgatcgcc ccggccgcgg cctcgatgtc
     4921 cgcgtccgcg aagaccacca ccggtgcctt cccgcccagc tccaggtgca cccgcttgac
     4981 gtcggccgcc gccgcgcccg cgacctcgat cccggcgcgg accgaaccgg tgatcgacac
     5041 ctgttgcgga atccggtgcg cggcgagttc cctgccggtg tcccggtcgc cacagatcac
     5101 gttgagcacc cccggcggca ggaactcggc ggccagctcg gcgagcagca cggtggaggc
     5161 cggggtggtg tcggatggct tgagcactac cgtgttcccg gccgccagcg cgggtgcgat
     5221 cttccagatg gccatcatca gcgggtagtt ccacggggtc acctgcgcgc agacgccgat
     5281 cggctcgcgc cggacgaacg aggtgagacc gggcaggtac tccgtcgccg ccgtgccctc
     5341 cagcacccgc gccgcgcccg cgaagaacct gagctggtcg atcgccatcg gcagctcctc
     5401 gctccgggtg agcgccagtg gtttgccggt gttcgccgac tcgcagcgga cgaactcctc
     5461 ggtccgggac tccagcgcgt cggcgatccg cagcagcgcg cgctggcgcc cggccggagt
     5521 gctgtcccgc cagccctcga acgcggtcgc cgccgcggta cacgcctggt ccacatcgga
     5581 cttgccggac agcgccgagg tggcgtacac cgtcccggtg gccggatcga cgaggtccag
     5641 ggtgcgtcct tcggccgagt cggtatgcct gccgttgacg aggttgcgga aggtctgttt
     5701 gtcactcatc ggttctccct ggcccagtgg cgacgtccgg aaggaagggc ggtgtgtgac
     5761 gcatggaaca acacggaatc agcaatgtca acgccctata tggaacgaaa tcagtcgtcc
     5821 tggcgtgcca gaacggcgga tccgcttgcc ggtggatgcc tggccgacct cgtccggccg
     5881 ggcgtggcgc catggccgac ggtagccccg gtggagataa tgcgccggtg aacaggaaga
     5941 accccgccgc cgagcgcagc tcggccacct tgctcgacga cacctccaag cggatcatcg
     6001 aacacctgca gcaggacggc cgccgcccgt actcgacgat cggccaggcg gtcggcctgt
     6061 ccgaggcggc ggtccggcaa cgagtccagc ggctttccga cgcgggcgtg atccagatcg
     6121 tggccgtctc ggatccgatg caggtcggcc tcttccggca ggcgatgatc gcgatcaacg
     6181 tggacggccc gctggaaccg gtggcggacg cgctcgccga gctggccgag atcgactacg
     6241 tgatcatctg cgccggccgg ttcgacgtgc tctgcgaggc cgtatgcgag gacgatgccg
     6301 ccctgctgga tctgatctcc aaccggatcc gcaccctgcc cggtgtgcgc aacgcggaga
     6361 ccctgatgta cctcaagctg cgcaagcagt cctaccagtg gggcacccgc tgaccagtcg
     6421 tcgcgaaatc cgttgccgcc agccttgaat ggcagctatt tcgtggctat gagcgctctg
     6481 cgcaactgat tcccttgcgc ggggtcggta tgtgtgcgat aacggaggtg accaagcggg
     6541 ccgggtgtcg aaccggcggc cgtaccgact ctcctgcgag ggaccatgac tgtcacagcc
     6601 gcatccaccc cggccgaacc ggacggcctt gcccgctcgg ccggcgagca cctgtggctg
     6661 cacttcaccc ggcactccgg ctttgccgac gcgcggatcc cggtgatcgt gcgtggcgaa
     6721 ggcgcctacc tctgggattc gggcggcaag cgatatctcg acggcctggc gagcctgttc
     6781 gccgtccagg taggacacgg gcgggaggaa ctggccgagg cggcagcgcg gcagatccgg
     6841 caactggcgt acttcccgct ctggggccag gcacacccga ccgcgatcga actggccgag
     6901 cggctcgcct gcgcggcccc cggcgacctc aaccgcgtct tcttcaccgt cagtggcggc
     6961 gagtccgtgg aaaccgcgtg gaagctggcc aaacagtact tcaaggtgac cgggaaaccc
     7021 accaaacaca aggtgatcag ccgctcgctt gcctaccacg gcacctcgca cggcgcgctg
     7081 tccatcaccg gaatcccggc cgccaagcag gacttcgagc ccctggttcc cagtggtctg
     7141 cgcgtgccga acaccaactt ctaccgggcg cccgaacacg gcgacgacta ccaggcgttc
     7201 ggcaggtggg ccgccgacca gatcgcgcag gccatcgagt tcgaagggcc ggacacggtc
     7261 gcggccgtgt tcctggagcc ggtgcagaac accggtggct gcttcccgcc gccacccgga
     7321 tacttccggc gggtcaggga gatctgcgac cagcacgacg tgctgctggt ctccgacgag
     7381 gtgatctgcg cgttcggcag gctcggccac gagttcggcg ccgcccgcta cgggtatcag
     7441 ccagacctga tcaccacggc caagggactc acctccggtt acgcgccact gggcgcggtg
     7501 ctggcaggcg agcggctgat ggagccgttc cggcacggca ccaccacgtt catgcacggc
     7561 tcaacctacg gcggccaccc ggtctcctgc gccgtggcga tggcgaacct cgacctgctg
     7621 gaacgcgagc acctctacga gcacgtgctg gccaaggagg gcttgttcaa gtcgaccctg
     7681 gacgagctga ccgacctgcc gatcgtcgga aacgtcaggg gcgcagggtt cttctacggc
     7741 atcgagctcg tcaaggacaa ggcaggcaag gagaccttca ccgccgagga atccgagcga
     7801 gtgctgcgcg gtcacctctc cagcgccctg ttcgaggccg ggctgtactg ccgcgccgac
     7861 gaccgggccg agccggtcat ccagctcgcc ccgccactga tctgcgaccg gccgcagttc
     7921 gacgagatcg ggcagatcct ccgggacgcg ctgaccgaag cctggaagat cctgtagcga
     7981 cgggccggac cgcggggccg ctcccgcggt ccgttcagcc gccttcgcgc cggcgagtcc
     8041 gtttcgcgcc tcgacactcc gagaaggcca gcagggccag caacgtgccg ccgcccgcca
     8101 gcgtgtatcc cagcgcctgg tgacgcgccc tggcgttacg gcagtccacg atctgttccc
     8161 agacttcccg gctgacgaac cgcttcgtcg cgccagtcca ggggcgatcg gctcccagca
     8221 accggtcgaa ccccacggag cgctccagcg ccgtgccgca ggcggtcacc gagcgcgcgg
     8281 cggggccgga tggcgtgacc ggtgccgaca ggacaccgac cgccccgata ccgcaggcga
     8341 tcgcggccag gacaagcccg tagcacaggc gcatggccgt tactttcgca tcctcgccgg
     8401 gagcagcgct caggcggggt ttgccgaggt ggacggcagc gggtgttcct cggcgagcgc
     8461 gtccggtgcc gagaggcgcc atgcctcata gagcagctcg ccgagctcgt ccgcgtcgat
     8521 ctccggcagg tggacgacga cccagccgaa cccgcccgcg gtgaactgca cctcgaacac
     8581 ctcgggccgc tcggccacca gggccacctg ctcggacagc agttgcttca ggcccaccgt
     8641 gctggttcgc ggccagtggt agccgaaacg cttgccgcgc acgctgaatg acgtgtagtc
     8701 ccgcgccttg gcactcgtga cctccgccag gtcgcgcacc atccgcagga actgatcgtc
     8761 cgaaacaccc atgcggatca ttcttgcgta ccccaccgac agcctgctcg ctcgcgccgc
     8821 cgtaccagcg ggcttgagca gggagcaccc ttcgtcccag gaacaccgat ggaccgggcg
     8881 gtggggaatg gctgagctgc ggtcgcggtg cgcggggctg agaagttggg taaagtttgg
     8941 gactcttctt ggccatcgaa ccaccgcacc cgcctgagcg tgccatattc agttgtgggt
     9001 caatcgaccg acaccggccg cccgtaaatc gcactagcgt cggcgctatc aatttgtgaa
     9061 acgtagggag taatacggtg tcgacgtttc cgcgtatcgg tattcttggc gaactggatg
     9121 tacgtaacgg tgataatgta ataccgtttc cggccgggaa tctccgggtg ttgctggcca
     9181 cgctggcctt gcgcgtcggg aaaccggtgg aacgcgacga gttgatcacc gcgatctggc
     9241 cggacgatcc gccaccgagt gcgcaggcca ccctgcgcgg ctacgtcaag cgactgcgca
     9301 gggtcctgat gaccggcgcc ggcgaggaga tctccgcggt gcgggcgacc gatggcggct
     9361 acgtgctgtg tctgcccgaa gacaacgtcg acctggtccg ctttcgcagg ctggtcgcgc
     9421 tggccgcggt gcgccgtgac gtgtacggcg agctgcccct tctccagcgg gccctcgcgc
     9481 tgtggcgggg ccccgcgttc gtcgacgtca gcagccctgc gctgcgcccc ggcgtggtca
     9541 acacgctgca cgaggagtac ctgcgggcca gggagcggga ggtggagatc cggctgcgcc
     9601 tcggccagta cgggtggctc atccccgaac tggccgccct cgtcgcggac aaccccttac
     9661 gggaaacgct gtggtaccag ctcgtgctgg cgctgcacct gaacggcagg caggccgaag
     9721 cgctcgccca ctacgagtcg ctgcgcgagt tgctcgccga ctcgctcggc accgacccca
     9781 gcccgctcat gcgggacctg caccagcgga ttctgtccgg gaagccgatg cgcacagcat
     9841 gctgagccgg ctatcacgta aagataacag atcaataaat gcgtgccacg ggcgtgccac
     9901 ccggttgcca cgcccggtcg gcagagttgg tttcacgcgg ggcgcggcca ccgatccggc
     9961 aaaacggacg cgcccgacgg acgaattgtg aggtgagatc gtggctgtcg aagccggatg
    10021 gcatttcgtc acgctgcccg atcacgacga ggcgaaggtg gtgctccggc ggctcgatgc
    10081 gagcgcgtac cgggtgctca accatccctc cggccggccg tggctgctga ccacgacccc
    10141 cagggaccag ctcgtggcgc atgccgaggg cccgaaccgt atcgcggtgc tcggctggtc
    10201 ctcggccacc gtacggcggc tggccgcggc cgcgtccggg cacgagctgt ccgctctcga
    10261 cgacctcgcc cacgaactgt ccggcggctt ccacctcgtc gccagcttcg aggggcgagt
    10321 tcgcgcacag ggcagcgcat ccgggctgcg gcgggtatgg cacgccgaga tcgacggcgt
    10381 ccacatcgcc tccgaccgcg ccgatgtgct ggccgagctg ggtgggcacc cgctcgacga
    10441 ggtggccgtg gcaatacgcc tgctgcgggt gctgccgcac ccggcggcgg agcagccact
    10501 gtggcagggc atccggccgg taccgccgga cagctacctg cgcctcgacc gggagcgggg
    10561 gcgcaccccg agcctggtgc gctggtggcg gcgtccggaa ccggagctca ccagggcgca
    10621 gggtgccgag cgcctgcgcg gggcgctgga agacgccgtg gccgcgcggg tccgggacgg
    10681 cctgaccatg cactgcgacc tgtccggcgg gctcgactcg accccgctgt gctacctcgc
    10741 aggtcgcatg accgcgccgt tgctggcctc gaccgcctac aacgacgatc ccggggcggg
    10801 ggaggacctg cggtgggcgc gacgcgcgct ttccgcgatg ccgagcgtcc ggcacgaggt
    10861 gctgtccttg gatgacatgc cggacttctt cggcggcatc ccggaactcc gggcccgcgc
    10921 ggacgaaccg accggcgcgc agctcgccat gccacgggtg gggtaccgca ttgagcacgc
    10981 cagggcacgg ggcgcggaca cctacctcac cggactcggc ggcgatcacc tgctgcgcgg
    11041 tgtgccggtg tgggaacaca ccctgttccg gcgccacccg gtgctggccc tgcgccgcgt
    11101 ctgggccaac cagatgctgg aaggcagacc gatgcgtacc acggtccggg cgctgctggc
    11161 caacgagtcc taccgctcgt ggttccggcg ttcggtgcgg acgggcgagt acgcccacat
    11221 gttcaccggt acccccaccc tcgactggga catcccgctg tcctggccga cctggctccg
    11281 gccggaggcg cgggacgcgg tgcgctcccg gctcaccgcg atcgccgtgg acgtcgagcc
    11341 gctcgggccg gaccgcgcga gccactccga gctggcgaag atccgcgacg gtgcccggct
    11401 cgtgcgcggg ttgcagcagt acgcgggcac catcggcatg ccgttcgagg ctcccttctt
    11461 cgatgaccgg gtgatcgagg cctgcctgtc cgtacggcgc cacgaacgcg tgcatcccaa
    11521 ggagtacaag ccacttgtca aggccgcgat gcgtggcgcg ctcccggacg actttctccg
    11581 ccgcaacggc aagaccggcg gtagcgcgca ggccgcacgc ggcctgcgcg gccacttcga
    11641 cgaactggtc gagttctgtg cgcgttcccc gctggccggg ctcggcctga tcgacatcga
    11701 caggttgcgc cgcgaggccg tcccgtcctg gtcgagaccg cgggatcgca acttcgactc
    11761 gacggtgaac tgcgcggcct tcctgcacac caccgcccga cgtagcgccg ctgacacggc
    11821 ggcctgaacg gaagggaacc gacatgccca tccggttgaa cgacgacgtc tcgagcgtgc
    11881 ggaccgatta cggcatggtc ctgctcgacg agaacaccgg cagatattac gaactcagcg
    11941 agaccgcggc ctgcgtggtc gaccatctcg acggcgagca cagcgaggac cgggcggttg
    12001 atgcgctcac cggccggttt gaggtcaccg accagcgcgc ccgtgcggac gtccgcgcgc
    12061 tggtcgccag gctggagtcg gccgggctgg tcacgacatg acactgcccg tgctcccgga
    12121 caccctggtc cgtgtctcga ttgcccgcag ggtgctgacc tggggcgtgg tcggtgtggc
    12181 cagggcgctc gcccggcggc cgccccggca gctccgccgc gcgctggaac gggcgagccg
    12241 cggcgcgcgg cccgccaccc acacggaggc caaggcggcg cgggacaccg tgctgaccgt
    12301 tagcacccgg tgctgcggcc cggaggcgtg cctgccgcgc tcgatcgcgg cggcgctgct
    12361 gtgccgcctc gacggcagct ggccgacctg gtgcgcgggg gtactgccga ccccgccgtt
    12421 cgccgcacac gcgtggatcg aggtcgacgg ggagctggtc gacgaacccg tggagccggg
    12481 ttactaccgc acgctcgtcc gcgtaccgcg tgcggcgcgg aaaggcttgg ccggacacgg
    12541 tcaagaacag gaaacacagt gatggatacg aaaggagatg gttccccatg cagcggaccg
    12601 cttacgagac gcccaccgtt gtcgagctgg gtgtgttcgc cgaggagacc ggcctggacg
    12661 ccccgcagaa caacgaggag gtcatcggca tcggtgacga ctggatcccg ccgttcgcgc
    12721 cgaagaactg agttcctgaa gaactgaggt actgaacgcc tgccgaaggc gtccgtacgc
    12781 cgtggccggt gcgtgtcgac gacgcaccgg ccacggcgcc acgcgcggga ggaccgtatg
    12841 cgaccagccg atcgcctact gtgccggact ctccttgcta ccagggtaac tggtatcctg
    12901 ctggtcgccg caggtgtcgt agatgccgcg acgcggatcg ccattcccgc ggtgctgggc
    12961 gccgccctcg acgaggtact cggcggcgca ggcccgctgt ctccggcgag ttcgctcctc
    13021 ctcgccctcc tgctggtggc cgtgctggcc gaaccggcgc gggagtacct ggccaggcgc
    13081 tgcgaactgc tcgggatgaa ggaactccgc gaccggtcga gccgacacgc gatctcgctg
    13141 ggagcgcagt cccggttcgc ccccgccgac agtcaggccc ggctgctcga atccacggcc
    13201 gaggcggcgc gcgtcagtac cgcgggactc accttgctga cctcggtgtg cacatcggtc
    13261 gccggactcg tcgcgctggt gctgatcgac cttccggtcg cattggtatt cctgtgcggt
    13321 gcgccattag tgtggtggct gacccgctgg ctgatcggcc gggtgggccg gatgaccgga
    13381 cgttatcaac gtgcccacgc cgatctcgcc gagcgcttcc tcgacgcgtt gaccgggata
    13441 cggacgatac gcgccagcgg caccgccgag cgcgagatcg gccggatcct cggcacgctt
    13501 ggtgaactgc gggaaaccgg ccatgactac tgggagaccc agcgccgcgc aggatggcaa
    13561 ctcggcctgc tcacgccgct gctcgccgtg gccgcgctct cggtcgccgg actcgggctg
    13621 ctggcgggca ggctcagcgc gggcgaactc gtcgcggtct ccagctacct cacctacgcg
    13681 ctcggcctgc tgcgccaggc ctccgtgctc gcgaagttcg cgcgcgcacg gggatctgcg
    13741 gaacggctct cggagctgct ggcgcaaccg gttccgccag agggatacct gccggccccg
    13801 gttggcgcgc tcaccgtgcg gctgcgcgga gtcagtgcct gtcacgggca ccggcgggtg
    13861 ctgggcgagg tcaacctgga catcccggcg ggaagctcgg tcgcggtgct cgggtcggac
    13921 ggggcggcgg catccctgct cgccgaggtc gtggccgggc tacgtattcc tgaccagggc
    13981 gcggtcctcg tcaacggggt ggctcagtcc gcgttcgatt cgcgggctct gcgcgagcgc
    14041 gtcggtttcg ccttcgcgcg tccgcacctg ctcggcaaca ccgtagccga cgccgtcgcc
    14101 tacaccgacg aaccaccagc accggaccgg gtggagaccg cgctggacac ggcggcggcg
    14161 cgcccgttcg tcgaccggtt acccgagggg gccgcaacgc cattacccgg actccggctc
    14221 tccggaggtg agacacaacg gctcggcatc gccagggcgg tgtgccggga cgtgggcctt
    14281 ctcgtgctcg atgatgctct gtccagcgtg gacaccgtta ccgaatcgac gatcaccgag
    14341 gcattgcgga cggtcgcgcc gggcgccacg cggctgatcg tcacgcacag ggccacgacg
    14401 gcggacgcgg cggatctggt ggtgtggctg gatggcggcc aggtccgcgc caccggtccg
    14461 caccgtgagc tgctcaacca agccggctac gccgcgctgt tcggctccgg acagccgcag
    14521 cgagaggccg cctcgtgatc cggccggtgc tggccgcgca caagcgcctg ctggtcacct
    14581 ttgtcctgtg gtgcctgctc ggcgccctgc cggtgctgct gtccggacgg ctgatcgcgg
    14641 ccgcggtgga cgtcggtttc ctcgccggca gcgccgtcaa tggcctgctg ctgctcggca
    14701 gctacggtgc cgtgatcgcg ctcggcagtt tcgccacacg gcaggccatc cggccgatgt
    14761 cggtgatcgt ggaagcggtt cgcgatcacc tcgtgcgctc cgtggtacgc ggtaccctgc
    14821 acaccgccgt acgtgaggac aggcccgccg agtcgggatc ggtggctcgc ctcacccggc
    14881 agaccgagca ggtccggcag ttactggccg gcctgctgat ggcactgcgc acggtcgcct
    14941 tcagcctcgt cgccgccatg gtcggcctgc tcaccttggc cccgctggtc ggaatcatga
    15001 ccgtgcccgc actggtcgcc tgcgggctcg tggtggcatc gctgtcgcgc gagtggcgca
    15061 aacgctacgc cgattcgctc gcgtgcgagg agcagctttc cggcaggctc gcagccgtgc
    15121 ttcccgccct tcgcgacgtg cacgcatgcg ccgcggcagg gcggacgacc ggcgaggtga
    15181 cggccgacat cgccacccac gtgcgtaccg cacgcggcgc ggcggtcatc ggtgcggcac
    15241 gggtcggtgt cgtgagcctg agtgcacgga tgccactggt cgcgctgttg ctggctgccc
    15301 cgtggctggt ctcgtccggg gcgctgagca cgggagaggt cgtcggcgcc gcgacgtatc
    15361 tgatctccgg gctggaaccg gcgctgcggt ccctcatgga gacggtggcc aacatggggc
    15421 tgcagctgtc cacgatcctg cgcaggctcg ccgcgcacgc ggccgagccg caagccctgg
    15481 tgcggggcat tcgttcccgc gcggctacga cctggcactg cgccaggtca cgtttcgcta
    15541 cggtccgcat tcccacccgg tacttgacgg ggtcgagctg gatatccggc acggtgagca
    15601 cgtcgcggtc gtggggccga gcggaatcgg caagtccacc ctggcctcgg tgctgtgcgg
    15661 cgctatcgag ccggatgggg gcaaggtgtc tctcggaggc acgccgttgc accggctcga
    15721 accaggggcg ctacgccgca gcgtggtcct cgttccgcag gaggcgtact tgttccgcgg
    15781 ctcggtgcgg gacaacctca gttatcaccg tgacgaccac cccgacgata tgacgatcac
    15841 cggcgccgtg acggccgtcg gcgcgcaaga gctgctttcc agcctcggcg ggctcggcgc
    15901 cgagctgctc ccgcgcacgc tttccgcagg cgagcgtcaa ctgctggtac tggcccgcgt
    15961 ctacctcggt tcggccgagg tcgtggtgct tgacgaagcc acctgccatc tggacgagac
    16021 caccgaggcg cgcgccgagc aggcgtttcg cagccgtggc tgcacgctgg tggtcatcgc
    16081 gcaccgcatc agctcggccc ggcgcgcgca gcgggtgctg gtgctggacg gcaccggcgt
    16141 gcgggacgga tcgcatgccg cactggtcgc caactcggat acctacgccg agctcgtcgg
    16201 ccactggtcg acgtgaacgc gctggcgggc agaatcccac catgccgatg ccgcacctac
    16261 ccgcacccgg ctccgctggt ctcgccgaac gggaggtcag cggtttcgcc gcccgctacg
    16321 cgcggttggt gcggtttgtc gtggtgtccc tgtgcggcgg agtgggggtg ctcgccgttc
    16381 ccgtcggcgg gatggccggg acggcgctca ttgttgccgc gatgatcacc tggagcggct
    16441 ggctgctccg gcggcgcgct cggccgacgg ccccggtcgt ggtggcggat ctcgtgctgc
    16501 tggcgggggt gtgcctctcg cagccgctga ccgtggggcc cgagccggtt tcgcacggca
    16561 acacctgggt atgcggggtg atctcgattg cgctggtgac ctaccagtgg tgttacccgc
    16621 cgctgcccgg cctcaccatc gccgcgttgc tggtaccgat cgacatggtt ggtgtcgcgc
    16681 tggccgatcc tcatggctgg acggccgatc tcggccttgg cgcctggatg ctcgtcgagg
    16741 ccgtgctgtc tcaagcgttg taccaggcga tccggcgcag ggctcgcgac tgggaccgca
    16801 aggctgagga ggtggccgag gcccgcaggc aagcgcgggt gagcgaggta cggcaccgcg
    16861 ccgagcgcga gcatctcgcc gtcctgcacg acaccgcgtg cgccaccctg ctgatggcat
    16921 cgatacctgg ctcggatgtc gccgaggtcc gcgcgcaggc acggcgggat ctggacacgc
    16981 tgacccggac cgaggacacg accaccgata ccgagctggg cacggcgttg tccgcggagg
    17041 ccgaggaaca cgccgtcgcg gtcaccgtga cggccgatgg ccaggtatgg ctgccagcca
    17101 ctgtcgcttc cgcgttgcgg gccagctccg gggaagcgct gcgtaatgtc gcacggcacg
    17161 cgggcgtacc ggaagccacg gtccgggtcg agcaggacgg ctgcggcaca gtggctgtcg
    17221 agatcgtgga caccggccgt ggtttcgacc cggacagcgt gccggcgccg cggaacggga
    17281 tccggtactc gatccaggaa cgaatgcgcg cggtagtcgg tcgggccgac atccgctcgc
    17341 gccccgggca cacgtcggtg cggctggagt ggcccgatgg ctgacccctc cacaccgcca
    17401 ccgggtggtc gcgtgctgaa cggcgcccgg ctggccacgt tcggcgtgct cgtagctgtc
    17461 catttcggac tttctttacc cgcgctcgtc tcgtcgtggg acgtctatgt ggacgcagac
    17521 caggccgccg tgggctacgc ggcactcacc gcgaatgtgg ggctgatcgg ctggttcgtg
    17581 ctgcgcggcc ggtcccagcc cgcctgggcg gtgcgtaccg ggctcgtggt cgcgattgcg
    17641 gcctcggtgc tgctgaccgc gcaggtgccc ggagaccagc tcgtgcggca agcgcactgg
    17701 accttccccg aactgggctg gcacggggtc atgctgctga tcgagcgacc cttcgtgcat
    17761 gcctgcgcgt tcctggccac ccatctggtg ctcaccgcca tccaggccat cctcatcgag
    17821 ccgccggacc ggatcgccgc gtccggcatg ctgatcacct cggtgatcac ctgcgggctg
    17881 caactcgcga tgtcatgggg catcaaggtg ctccggcggt acttggcacg ggccgatgcg
    17941 gcggcacgcg aacgggaccg ggtgctgacc gagaacgccg tgtccgttca gctccgcctg
    18001 gaccggcgac gtcgggacgc ggaccacgcc gcggacgtgc tcaccgtgct gcgcgggctg
    18061 gctgatggct cgctcgatcc cgacgacgag cggacgcggc ggctctgcgc ggtgcgggcg
    18121 gcgaccttgc gcaggctgtt cgcggagaac gaaacctcgt ccgaccggct gctgcacgaa
    18181 ctgcgcgcgg gtatcgacgt ggccgagcgt ggcggggtca ccgtgcagct cgccgtgcgg
    18241 ggtactccgc ggtcgctccc gatacgggtc cgcagggcgc tgaccgatgt tgcgatcgcc
    18301 ggaatcgcgg ccgcgcgacg gaccgcacgg gtgaccgtga tccacgcggg gcaggtgcgg
    18361 gtcagcgtgg ttacggacgc gccggacatc gagctgcctt ccggagcgga cgccggcgtg
    18421 gcggcctccg caacgcacaa tggtgggaag ctgtgggtcg aggcgaggta ccccgttcac
    18481 aggtcgtcca gtgccaccag cccgtcctga atcgccctgg ccactaggtt cgccttggtg
    18541 gctgcggggc ggcccacgtt ggcgtacttg acccgaacac ggtcgagata ggagctgacc
    18601 gtgcgcgtcg acaggccgag gctctcggcg accattgcct tggactcgct ttggaaccac
    18661 tcgatcagca cctcggcctc gcggggcgtc aacgcgggcc ggtctggggc ggtgttgcct
    18721 gcgaatgctc cggcgagcgc cggaggtgtg tacgggcacc cgctcgccgc ggcccgcgtc
    18781 gccgggacca ggtgctccgc gccctcggcc ttggtcaggt aggtgaacgc gccgagttcg
    18841 aggcagttca acgcggtctg ctggtcgtcg cgcatggtgt agacgatgac ctggcgatca
    18901 gcctcgacga gcgtgcgcag gtcatggaac accgaggcgg ccgggccgag acggagatcc
    18961 agcacaacga cgtcggcggc gttgccggga ggggtcatcg cgacgcccat ggtcgtgccc
    19021 tcggctacaa cggatatcgg cggaatcgcc tgggagtacc acgagcggac gccggccagt
    19081 accactggat gatcatcgat gacgctgact gtcaccggtc gacccatgtg aggcatcctc
    19141 ctcgtggcat ctgccgtgga ccgtcggata ccgatgaggt aatcatgatt gtgtacgggc
    19201 tcgccagcgc gccggctcga catcgcccgt gccggggccg cggccggcca ggaccggaac
    19261 gcggagtacg tccggtcgtg gcgacacgct ggtgtctgtg ccggacgagg cgggtgttcg
    19321 caacggaacc ggcggtgggg tggctggttc ggtgggacgg tgccgcgggg atccgcaaga
    19381 cgacactggc ggtgcagtgg gagcatcggg tgcaggaccg gttgcctgac ggcacgttgc
    19441 aggtgagcct gcgcggccac gagcttgggg atccggccac gcccggtgag gtgctggagg
    19501 ggttcctgtg ggcgctgggt gtcgcggccg ggcggatccc cggggccagg aggggttatc
    19561 cggcccccgt acggcattgc cgaagaggag gttgaggaca gcctcactgt gctgatcgtt
    19621 cgcgcccgcg gcggtagttg cccgcggcgg tagttgtctg taccgcagga tagccgcgta
    19681 ggccgacctc ggccggtcgt cccgcggaga tcatcgtgta gatctcgcgg accgggtagg
    19741 tctggatggc tctgacctgg tgggcgaact cgtcggtgat gtccgctaga agttcgctgg
    19801 gtacgcgctc gttgcgcact gcctgttcga tccagccgag gtgggtctta ggcttccgcc
    19861 gatcgtcctt actccgtcag ccttggcacg tccatcacct ccgtaccagc cgatcaacca
    19921 ccgacgctgg aacattaacc aatgtcgagg tcaagatgcc ggctgaacac ccttggctgc
    19981 gccgctgctg tggccgggag ttcggggtgt tgcggctggt gtccgctggg ccggatgccg
    20041 cgggtgtgga ggccgttgat gagggcggct agcgccgcgg cgactcggcc gggcccgctg
    20101 ttgcgccggt ggcgcaacag cgggtggagt ggttcaggct tggccggtgt cgaagcgggt
    20161 gatggtgccg tcgttgatgg tgaagtgcca gcgggtgcgc attgtgcccc agctggagtt
    20221 ggtaaacctg gcgatgaggg cgcgtccgtc gtcggattcg gattcgacgt ccattcggcc
    20281 ctcggccgag aagatctcct ggtccaccca gctgtcgaga ttccggtctg tgccgtcgtc
    20341 ggacatggcg gctcccgggg ccagcaggga gtcgaacgcg tcccggtcgc cggtgttgat
    20401 cgcggtgacg aacgcgcgca cggtcgggtt ggtcggtagg tcggccataa ctgtgttcct
    20461 tcctaggtgg ctcggggtgg tcccagcgat ccggaaccat cccgagcctg cgtgatccgg
    20521 tttagttgtg ccagttcagc gggtggtgta gccgccgttg gtgaagatgg tccgcccggt
    20581 gatccaccgg ccatcggtgg ccaggaaacc caccgatggc acgatgtcct cgatctgggt
    20641 gagccggtta cccagggtct gagacttgtg gaactccacc cgttcgagtc tcctgcgggt
    20701 ggcagaacgg ggtgtccatc gggctcggtc cgatattgtt gaccgagatg cccggccggt
    20761 gaactccttg gtggcaacgc gagtgaagtg ttcagcggcc tggcggccgg cgtagctggc
    20821 gcagccgtcg gtgtaggcgg ccagtaccca cctcggcggt ggcggcgtcg aaaggcgccg
    20881 aacctggctc acctgagtga ggtcaccctg caaccgagac agggcaccgt gtgcaacccc
    20941 ctcctgggtg attccgatcc gtgcgaccgc atcggagccc gtgtatcgac gctgagcgcc
    21001 ccggccgtcg cgccctcggc agggtgggcc gaaccgggtc gagcagccgg attcagcctc
    21061 agttgaaacc gatgttcctg gttaccggcc ggtcgtatat tgagtgcgcc aattgtttgg
    21121 catgttgttt cgttggcgat tcggtacgcg gaaggggtgg gttaatgagg ttcaaagcgt
    21181 tggttctgac cgtggtcacc gcgtctggtt tggttgttat gcccgcgatg gccggggcgg
    21241 aaacgagaat cgcggacacc gggatcacga ccccgaagaa tgtcgtcacg ccgccgggct
    21301 gggtccggga catgcctgct ccggcaaccg tcggagacgt cggtacggcg gccgtgctgg
    21361 acatccagta ccaggtgcag cagaccgggt actggtgcgg ccccgccgcc acccggatcg
    21421 cgatctcggc gcgccggagc aacccgccga gccaggcgac gctcgcagcc cagctgccga
    21481 caaccaccaa cggcaccgac tggatcggcc aggtcaccag ggtgctgaac cagaacctcg
    21541 gcacagggtg gtacgagacg aaggagatgc cgaacgaccc gccaacgcag gcacagcggg
    21601 acctgctctg gcgggacatc gtgctggaca tcaacaacgg atacgccatc gtggcgaaca
    21661 tcgtcgcccc gccgagcaac catccacccg gatacccgaa ctacacggtc taccactact
    21721 tcacggtaat cggttatgac agctcggaca tgacggtcaa gatcgccgac ccggccaact
    21781 tcggcgggaa caagatctac tggctcacct tcaaccagct tgcgacgctc attccgccga
    21841 agggttactc ggcctgagga cggtggtgtc gtggcccttc ggcggtccga cggacggccg
    21901 aagggccatg atgccgttcg gcgccgggcg gtcgatcagc cgtccccggt ggccggtcca
    21961 gcagcatggc tccccggtcg gacaccgcgt gtacagcgtg gccgtggcac cggcgggtgg
    22021 tcaccaggcc tgcttccctg agcaccgcgg catgctggga cgcacccgcg acggaggtgc
    22081 ctgcggcgcg ggcgagttcg gtggtgttca ggtacggcgt atccgcgatg gtccggagga
    22141 tcgtggccct ggtccggccg agcagcgtgg cgagtgatcg cgcgtgccgg gcggaggact
    22201 gcgatgcgca gctcgtgtcc tgccgttccg ccatccagcc cgggatcggg tcgaccggat
    22261 acaccagcag gggcggcagg tccggatcgg cgaaggtcat cgaggtgcgg cggcagaaga
    22321 acgaagggac cagtaccagg ccgcgaccgt ccaggtgcag ttcctgctcg accgggtagc
    22381 cggcttcaag gaccggggca cgccaccgga tcgaagggtg cagcgtggac aggacctggc
    22441 cgagtccgct ggtggcggcg agttccgtac gccgcgccca gtcggcgcgg atgtgggctc
    22501 gaagtacctg ctcatagggc tgaagcgcct cggcgtgata ccggcggata cgctcggtga
    22561 ct
//
