LOCUS       NZ_CP036117            23917 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Bacillus mycoides strain JAS481 chromosome, complete genome.
ACCESSION   NZ_CP036117
VERSION     NZ_CP036117.1
KEYWORDS    RefSeq.
SOURCE      Bacillus mycoides (Bacillus weihenstephanensis)
  ORGANISM  Bacillus mycoides
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Bacillus; Bacillus cereus group.
REFERENCE   1  (bases 1 to 5296574)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5296574)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 187.86x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018741645.1-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 04:46:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,189
            CDSs (total)                      :: 6,036
            Genes (coding)                    :: 5,734
            CDSs (with protein)               :: 5,734
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 302
            CDSs (without protein)            :: 302
            Pseudo Genes (ambiguous residues) :: 0 of 302
            Pseudo Genes (frameshifted)       :: 122 of 302
            Pseudo Genes (incomplete)         :: 192 of 302
            Pseudo Genes (internal stop)      :: 81 of 302
            Pseudo Genes (multiple problems)  :: 78 of 302
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:51:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5026674
            Orig. end                         :: 5050591
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036117.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23917
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="12"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23917
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23917
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13917](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13917)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(1361..2242)
                     /gene="galU"
                     /locus_tag="EXW43_RS26340"
                     /old_locus_tag="EXW43_26905"
     CDS             complement(1361..2242)
                     /EC_number="2.7.7.9"
                     /GO_function="GO:0003983 - UTP:glucose-1-phosphate
                     uridylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006011 - UDP-alpha-D-glucose metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="galU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000757771.1"
                     /locus_tag="EXW43_RS26340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26905"
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="WP_215576029.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.7e-09, bitscore:
                     35.0, seeds: 297, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.6e-06,
                     bitscore: 24.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVRKAIMPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIVEEA
                     IESGIEDIIIVTGKGKRAIEDHFDHSFELEQNLLEKGKYEMLEKVQASSKINIHYIRQK
                     EPKGLGHAVWCARKFIGNEPFAVLLGDDIVQADTPCLRQLMNEYEATHSSVIGVQTVPE
                     NETHRYGIIDPITQNGRQYQVHRFVEKPAQGTAPSNLAIMGRYVLTPEIFMFLEDQQTG
                     AGGEIQLTDAIQRLNEIQHVFAYDFEGTRYDVGEKFGFIKTTIEMALQNEELKLDLMKY
                     IKELVKKEEVHS"
     gene            complement(2492..3259)
                     /locus_tag="EXW43_RS26345"
                     /old_locus_tag="EXW43_26910"
     CDS             complement(2492..3259)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000566222.1"
                     /locus_tag="EXW43_RS26345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26910"
                     /product="tyrosine-protein phosphatase"
                     /protein_id="WP_002184595.1"
                     /transl_table=11
                     /translation="MIDLHCHILPNVDDGAQSIEDSIAMAKAACEEGIHTIVATPHHQN
                     GVYMNLAESILHQVKQLNERLKEEDINLTILPGQEIRLYGELLEDYDSRRIVTLNRTDK
                     YILIEFPTNHVPRYAEKMLYELRVKGITPVIVHPERNMEIIERPDVLYKLVNQGALTQI
                     TAGSVTGKFGKKIKKFSLQLIEHHLTHVISSDAHNTTTRSFHLQAAYETVEKTFGSSTL
                     YDFKENTYELISGKMIYREEPEKIRQRKIFGLF"
     gene            complement(3343..4032)
                     /locus_tag="EXW43_RS26350"
                     /old_locus_tag="EXW43_26915"
     CDS             complement(3343..4032)
                     /EC_number="2.7.10.2"
                     /GO_function="GO:0004713 - protein tyrosine kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0004715 - non-membrane spanning protein
                     tyrosine kinase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000243180.1"
                     /locus_tag="EXW43_RS26350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26915"
                     /product="CpsD/CapB family tyrosine-protein kinase"
                     /protein_id="WP_002184594.1"
                     /transl_table=11
                     /translation="MVLKKKILRARRQLIAYEQPKSSVSEQYRNIRTNIEFASVDKKIR
                     SLIVTSANQSEGKTTTAANIAVVFAQQGKKVLLIDADLRKPALHQMMQVDNIFGLTSVL
                     TRSNTLETCVTQTKIGNLTFLPCGPIPPNPAELLGASSMKDLLSEAFGTYDLVIFDTSP
                     ILPVTDAQIMANQCDASVLVIRSGVTEKEAALKAKQSLDSAKGTLLGVVLNDKEQNGSE
                     YYYYGSN"
     gene            complement(4022..4759)
                     /locus_tag="EXW43_RS26355"
                     /old_locus_tag="EXW43_26920"
     CDS             complement(4022..4759)
                     /GO_function="GO:0004713 - protein tyrosine kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216: exopolysaccharide biosynthesis domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000393146.1"
                     /locus_tag="EXW43_RS26355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26920"
                     /product="YveK family protein"
                     /protein_id="WP_215576030.1"
                     /transl_table=11
                     /translation="MEETISLKELFAILRKRLVMILVITIGAALVSAIVSFYFITPIYQ
                     TSTQILVNQKKQEGVFQPGEVQTSLQLTNTYKVIVKSPVILDQVKEKLKLNMSTGALNS
                     KINVANEKDSQVIAVTVQDKDEKLARDIANTTAEVFKSEIAKIMSVDNVTILSKAEVTE
                     GQSPIKPNKMLNVAIAFVVGLMASVGIAFLLEYLDNTMKKEEDIEKQLGVPVLGVVSHM
                     EEDGTKSGSLSATKRVGGHTIGS"
     misc_feature    complement(5146..5157)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.03"
                     /tool="antismash"
     misc_feature    complement(5201..5214)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 20.13"
                     /tool="antismash"
     misc_feature    5205..5218
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 22.91"
                     /tool="antismash"
     gene            complement(5358..5792)
                     /gene="fabZ"
                     /locus_tag="EXW43_RS26360"
                     /old_locus_tag="EXW43_26925"
     CDS             complement(5358..5792)
                     /EC_number="4.2.1.59"
                     /codon_start=1
                     /gene="fabZ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1270: UDP-3-O-[3-hydroxymyristoyl]
                     N-acetylglucosamine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000931961.1"
                     /locus_tag="EXW43_RS26360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26925"
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="WP_088038320.1"
                     /transl_table=11
                     /translation="MLDIQQIKEIIPHRYPFLLVDQILEVEEGKRAVGIKNVTVNEEYF
                     NGHFPDYPVMPGVLIVEALAQVGAVAVLKKEENRGRLAFFAGIDNCRFKRQVRPGDQLR
                     LEVEMTRVRGPIGKGKAVATVNGEIACEAEITFAIGDKKE"
     misc_feature    complement(6743..6759)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: medium, score: 28.12"
                     /tool="antismash"
     misc_feature    6810..6826
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.27"
                     /tool="antismash"
     gene            complement(6986..8788)
                     /locus_tag="EXW43_RS26365"
                     /old_locus_tag="EXW43_26930"
     CDS             complement(6986..8788)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002191245.1"
                     /locus_tag="EXW43_RS26365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26930"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_002184591.1"
                     /transl_table=11
                     /translation="MRNILYFTKRLYSFTGNILIVNLMGMVLVSLVEGIGILLLIPMIS
                     ISGIAKMNEQTSPLSGVLGFLGEIPTTLGLPLVLGIYIILVVGQALLQRNITVRNAKIQ
                     IRFINHLRLETYRGLLQANWSFFVKKRKSDLINSLTTELGRVSAGTNLFLQLLTSLMFT
                     FIQIGFAFWLAADITIFVLCCAVVLAFLSRRFIKKSKRLGGRTSENSKAYLAGITDHFN
                     GIKDIKSNTLERSRYMWLRNWAEDVEREQFAYIKVRNNSQLFYKIASAVFIAILIFLSV
                     QLFQTKTEQLLLIILIFSRLWPRFAGIQSNMEQIAANLPAFKDLLQLQEECKKSIELQD
                     IEQNYDCINPMQIEQSIECQNISFRYNKENAVYSLKDINLRIPANCMTAISGRSGAGKS
                     TLIDIIMGLMQPESGQLLIDNKPLTSKDLLSLRKSISYVPQDPFLFNASIRDNLRMVEP
                     NASEEQLWEALEFSASAEFVSRLSQGLDTLIGDRGVKLSGGERQRLVLARAILRKPSIL
                     VLDEATSALDAENEAKIQEALERLKGSMTIIVIAHRLSTIRKADQVIVMDQGQIIQHGS
                     FAQLAKDESGLFSSLLGQQAKVNI"
     gene            complement(8791..9978)
                     /locus_tag="EXW43_RS26370"
                     /old_locus_tag="EXW43_26935"
     CDS             complement(8791..9978)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000287953.1"
                     /locus_tag="EXW43_RS26370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26935"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_044439470.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 1.2e-60, bitscore:
                     203.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTGCNLDLSHLPKELKLLLEIIKKEDKEIQEIPGDWFINIDWNK
                     FLKLALHHRMYAFIYPKMKSIDKQLVPSNVVQVLSTYFKRNTFHMLHLSGEMGKVSKLF
                     AENQLQLLFLKGPILGADLYGDVSLRTSGDLDALVPIDDLGKVNELLVKNGYVKEDDFP
                     TVMNEWKWRRHHTTYMHPISKVKLEIHWRLHPGPGKEPHFDELWGRKRTSPVTNYPVYF
                     LGREDLFMFLVTHGTRHGWSRLRWLTDIDRMVRQEIDWEELTVMLERYGCKRLVGQALI
                     LSSELLDTLIIAEEAKVLMSGRKVTQLAQLAIYYLENMINLHTDPVPEEVSKYHERYLY
                     LLKTSSQKLLFHLSWLYPYPQDVETLPLPKQLHVLYFPLRPVLWIWREMRYRKEK"
     misc_feature    9989..10004
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.51"
                     /tool="antismash"
     gene            complement(10001..10453)
                     /locus_tag="EXW43_RS26375"
                     /old_locus_tag="EXW43_26940"
     CDS             complement(10001..10453)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016130929.1"
                     /locus_tag="EXW43_RS26375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26940"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_001021513.1"
                     /sec_met_domain="PF13471 (E-value: 4.5e-25, bitscore: 86.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIINKAKAFLSFDMGTKLLLIEAFFYLGWARILKSIPFSKAAPI
                     LGIHMAETSLSYDESEKITLRKISQAVHMMSRYTFWESQCLVKAIAAMKMLEKRQIEST
                     LYLGTAKDETGNMIAHAWLRSGPFYITGVEEMKRFTVVGKFAKRIG"
     gene            complement(10499..10798)
                     /locus_tag="EXW43_RS26380"
                     /old_locus_tag="EXW43_26945"
     CDS             complement(10499..10798)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002191248.1"
                     /locus_tag="EXW43_RS26380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26945"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_000095761.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 9.3e-25,
                     bitscore: 84.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-14, bitscore: 52.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSKQTISLHSFVVQGQENVVSDMDGEKVMMSIHNGKYYNLGGIG
                     GEIWSLINELISVNQVIDILLSRYMIEEAECKEQVLSFLNHLYAEGLISVDEKL"
     aSDomain        complement(10514..10762)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EXW43_RS26380_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="4.90E-27"
                     /identifier="RREFam002.1"
                     /label="EXW43_RS26380"
                     /locus_tag="EXW43_RS26380"
                     /protein_end="95"
                     /protein_start="12"
                     /score="84.8"
                     /tool="antismash"
                     /translation="VVQGQENVVSDMDGEKVMMSIHNGKYYNLGGIGGEIWSLINELIS
                     VNQVIDILLSRYMIEEAECKEQVLSFLNHLYAEGLISV"
     gene            complement(10798..11727)
                     /locus_tag="EXW43_RS26385"
                     /old_locus_tag="EXW43_26950"
     CDS             complement(10798..11727)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000582033.1"
                     /locus_tag="EXW43_RS26385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26950"
                     /product="aldolase"
                     /protein_id="WP_002184589.1"
                     /transl_table=11
                     /translation="MIHTVKKEIYKAFGLALLSEIPLPELPQVSNYENEVDVKIETADL
                     SQLWGELSSPKSVFVVEEELIMFQIPETATFCIQNGEKIIVSPMKGSDQDKIRLYILGT
                     CMGALLMQRKILPLHGSVIAINGKAYAFVGRSGAGKSTLASALLSKGYKLLSDDVIAVS
                     LSEDNTPFVTPSYPQQKLWKESLDQFGMETAHYQPLFERETKYAVPVTANFFEEPLPLA
                     GVFELVKVENGDVELQQIEGLERLRTLLRHTYRNSLIPRLGMMEWHFMHSTNIVNKIDM
                     FQLRRPISKFTAHDLVSKILESLKEEEK"
     gene            complement(11834..11965)
                     /locus_tag="EXW43_RS26390"
                     /old_locus_tag="EXW43_26955"
     CDS             complement(11834..11965)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016130932.1"
                     /locus_tag="EXW43_RS26390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26955"
                     /product="paeninodin family lasso peptide"
                     /protein_id="WP_000808480.1"
                     /transl_table=11
                     /translation="MKQEWQSPVLEVLDINMTMAGPGKRLVDQVFEDEDEQGALHHS"
     gene            complement(11980..13917)
                     /locus_tag="EXW43_RS26395"
                     /old_locus_tag="EXW43_26960"
     CDS             complement(11980..13917)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001274527.1"
                     /locus_tag="EXW43_RS26395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26960"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_088038324.1"
                     /sec_met_domain="GATase_7 (E-value: 1.4e-18, bitscore:
                     65.3, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 9.8e-22, bitscore:
                     76.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAITGIYHLNGEPIPPEHRIGIMKDLSRYPGDNTDIWHKENIFF
                     GSHAKWITSESINEQLPYYDYETQLVITADAIIDNRNELFDRLQVDKVHRREMPDSKLI
                     LLAYQKWGEHVPKYLIGDFTFMIWDERKQLLFGARDFSGSRTFYFYRNQNQFAFCTSIQ
                     PLFSLPYVGKELNEQWLAEYLAIPNMLDTIDAFSTVHKNIEQVPPSHTISVVKGRVSIA
                     KYDTLFVEEQLQLKSNEDYEEAFRDVFESAVTSRLRTHRNVGSHLSGGLDSGAVASFAA
                     RALQKENKKLYTFSSVPAEGFTDWTRGHTIADEKPFIQTTVQHVGNIKGNYLNFPGENS
                     FSEIDDWLEIMEMPYKFFENSVWVKGIYEKAQQQGIGVLLNGARGNFTISWGPALDYYA
                     ILLKKFSWLQLYREIDLYGKNVGVKKSRILKVIGEKAFPSIKNMFSSEQQYELPTLVSP
                     ELAKRTDVFRKLEEHGVKVTGASIPNIYEIRQKHFEQLNLWNTTGTSGTKLSLRYGLQG
                     HDPTNDLRVIRFCLSLPLEQFVQNGLNRALVRRSTKGFLPDKVRLNQRVRGIQAADVVH
                     RMIPSWKMFIEELQQLSKDPVASNFFNMEIIKSAILKIQGEPRVEYVFDPDFRILMRSL
                     IVYRFIKKYI"
     misc_feature    complement(14139..14153)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 23.33"
                     /tool="antismash"
     gene            complement(14948..16117)
                     /locus_tag="EXW43_RS26400"
                     /old_locus_tag="EXW43_26965"
     CDS             complement(14948..16117)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Aminotran_1_2 (42-168). E-value:
                     1.2e-08. Score: 26.4. Matches aSDomain:
                     nrpspksdomains_EXW43_RS26400_Aminotran_1_2.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018781216.1"
                     /locus_tag="EXW43_RS26400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26965"
                     /product="aminotransferase class I/II-fold pyridoxal
                     phosphate-dependent enzyme"
                     /protein_id="WP_002184586.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.5e-95,
                     bitscore: 318.8, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-06, bitscore:
                     26.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVYSQEKTRIYLSAPHMSGNEQKYIGEAFDMNWIAPLGPNVDAFE
                     SELSSHVGVLDAAAVSSGTSAIHLALRLLDVKDGDTVFCSSLTFIASANPILYLGAKPV
                     FIDSELETWNMSPQALERALRDANEKGVLPKAVIVVNLYGQSAKMDEILSLCNTYNVPV
                     VEDAAESLGSSYKGKASGTFGKFGVYSFNGNKIITTSGGGMLVSDDVEALRKARFLATQ
                     ARDPAPHYQHSEVGYNYRMSNILAGVGRAQLQVLQERVHARRRIFDRYYQELSHIPGIQ
                     FMPELEDTYSNRWLTVLTVDEEKTGVPIQALLKQLENENIEARPVWKPLHMQPLFEDVM
                     YYPHSEGEDVSRKLFETGVCLPSGSGMTEKNQTRVITCIKNILMVSAGM"
     aSDomain        complement(15614..15991)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW43_RS26400_Aminotran_1_2.1"
                     /evalue="1.20E-08"
                     /label="EXW43_RS26400_Aminotran_1_2.1"
                     /locus_tag="EXW43_RS26400"
                     /protein_end="168"
                     /protein_start="42"
                     /score="26.4"
                     /tool="antismash"
                     /translation="AFESELSSHVGVLDAAAVSSGTSAIHLALRLLDVKDGDTVFCSSL
                     TFIASANPILYLGAKPVFIDSELETWNMSPQALERALRDANEKGVLPKAVIVVNLYGQS
                     AKMDEILSLCNTYNVPVVEDAA"
     gene            complement(16131..16763)
                     /locus_tag="EXW43_RS26405"
                     /old_locus_tag="EXW43_26970"
     CDS             complement(16131..16763)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002184585.1"
                     /locus_tag="EXW43_RS26405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26970"
                     /product="acetyltransferase"
                     /protein_id="WP_002184585.1"
                     /transl_table=11
                     /translation="MRIIMIGAGGHSKVIRDIILSYGNYEIIAQLDDVYKELKIEDGVY
                     FGPISAAVKLMDEHVDTKFVIAIGNNRTRKIIMEQLEIPSHRYATLIHKQSIVSLSAKI
                     GAGTVIMPGAIVNADVGIGNHVIVNSGAIIEHDNKVNDFAHISPNAVLTGSVTVGTGVH
                     IGAGVNVIPNITIGDWSVIGAGATVIRDIVANCKAVGIPARVINKEL"
     gene            complement(16777..17373)
                     /locus_tag="EXW43_RS26410"
                     /old_locus_tag="EXW43_26975"
     CDS             complement(16777..17373)
                     /EC_number="2.7.8.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002191254.1"
                     /locus_tag="EXW43_RS26410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26975"
                     /product="sugar transferase"
                     /protein_id="WP_002184584.1"
                     /sec_met_domain="Bac_transf (E-value: 1e-66, bitscore:
                     222.1, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRLFDLFVSLSLLVFLLPLIIIVAVLVRIKLGSPIIFKQQRPGL
                     HGVPFFLYKFRTMTDEKDSEGNVLPDDVRFTRFGGFLRKYSLDEWPQLFNVIKGDLSLV
                     GPRPLLMEYLELYTEEQAKRHNVRPGITGWAQVNGRNAISWEEKFDFDVWYAKKRTFWL
                     DMKILLLTAKKVFKSEGINQVGHVTVEKFNGTKNS"
     gene            complement(17721..19268)
                     /locus_tag="EXW43_RS26415"
                     /old_locus_tag="EXW43_26980"
     CDS             complement(17721..19268)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001264123.1"
                     /locus_tag="EXW43_RS26415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26980"
                     /product="lipopolysaccharide biosynthesis protein"
                     /protein_id="WP_002184583.1"
                     /sec_met_domain="Polysacc_synt (E-value: 6.8e-11, bitscore:
                     40.4, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVKNSIINISAGIGSQVIITLLSFASRTIFITYLGVEYLGVNGL
                     FTNILGMLSLAEAGIGSAIIYNLYKPVAENNQDRINMLMNFYRKAYMAIALIVLLLGLL
                     LLPFLGYIAKDAKVDNIHFIYIIFLINTASSYLFSYKTSFLNVCQKGYIVTGIYSISSI
                     ISTCIKIGILYFTHSYILYLIIDIIITISTSAFLAILVDKMYPFLKNKAASKLDSETKS
                     NIVKNVKALVLHNIGGYIVFGTDNMLIASFVSVTAVGLYSNYYMLINICRTFINQIFDN
                     INHSVGNLVAKESDEKIYSIFKITMLCNFWIYSFFSIFLYIIMQPFITLWIGSKFIMDI
                     SVLIILMMNFYVSGMRRSISMVKTTSGIFHEDRYAPFLEAAVNLVASIVLVQYMGITGV
                     FIGTLISTLVVPFWIAPYLVYKKVFRKPVRDYFLKYTYYVMIGLGACVITSLICGLIPY
                     NGLLELILRGMICLIIPNTIYVFVFYKTDEFKYLFGVVKSIMGNLRVKIQSNKKGTF"
     gene            complement(19317..20324)
                     /locus_tag="EXW43_RS26420"
                     /old_locus_tag="EXW43_26985"
     CDS             complement(19317..20324)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002191256.1"
                     /locus_tag="EXW43_RS26420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26985"
                     /product="glycosyltransferase"
                     /protein_id="WP_033734338.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.6e-40,
                     bitscore: 134.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHELISVIVPIYNVEKWLARCIESVLKQPFVNIELVLVNDGSTDK
                     CGEICEEYLEKDNRIKVIYKENGGVSSARNAGIEAATGKYIVFIDPDDEVSENYFTRLY
                     GIAEDKKCDAVICGYKTVPNNNSIIPNFKLDTVMNGRDFVLSSPNVHSKNDLCFAWRYI
                     YNLSIIKEENIRFNEQVFIGEDVIFNLEFLLHSQRVCAVSEVLYFYTINNPNSLMRVPY
                     KPNLENSLVLQYQMRRQLSQEFGLLHDKQFKKDMANYYINHIYRLLINNLKSAPNVDVN
                     NAFRRIVNYEMFSDSVKGIGFSYRCNNFKEYIYYLAIKFKVYPLIVAAYKREIR"
     gene            complement(20368..21294)
                     /locus_tag="EXW43_RS26425"
                     /old_locus_tag="EXW43_26990"
     CDS             complement(20368..21294)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127644.1"
                     /locus_tag="EXW43_RS26425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26990"
                     /product="SP_1767 family glycosyltransferase"
                     /protein_id="WP_002184581.1"
                     /transl_table=11
                     /translation="MVQIKIKSMLVFIWNKWIDIKIQSLNRLTIIKDRFTKCFFKPPRI
                     QSIDETLKKIIHDKASVARYGDGEFKLIHNLDITFQRADHLLSKRLKEILLSEDEKFLV
                     CLPDVFQDLSKYADEPKDYWSLHTAKYRLKWYKDLKKGKVYYNSFISRFYYPFRDKSKC
                     KEWFILLKLIWKDRDIVLIEGSKSRLGIGNDLFENAKSIERILVPEEHAFLHYNNILTA
                     AKKNNKSKLILLAIGPTATILAYDLYKEGYQAIDIGHVDIEYEWFLRQAKTKIKIENKY
                     VCEAGAGQNVGDIQDEKYLSEIKAVIR"
     gene            complement(21423..22589)
                     /locus_tag="EXW43_RS26430"
                     /old_locus_tag="EXW43_26995"
     CDS             complement(21423..22589)
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1088: acyltransferase 3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003192586.1"
                     /locus_tag="EXW43_RS26430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_26995"
                     /product="acyltransferase"
                     /protein_id="WP_215576031.1"
                     /transl_table=11
                     /translation="MTRRYKELDSLRGIAAIIVLLGHFLALFPILGKKVMYSTFGAYFS
                     ILWQGHSAVIIFFVLSGFVLSLPFYKGTEFNYLKYLIKRVCRIYIPYIVILFIAIGIKL
                     GIHSKIGTIPGLVQWGSWNIEVSFNRVMDHILFLREFNSDAFIMVIWSLVHEMRISIVF
                     PLIIFLLLRVNWKVSIGIAMFLSVIGYLLMKNIPSEFNMPVSTNYFITLHYSSMFIIGA
                     LLAKNREYLVSKIINSKVKYILLPLGLLFFSYPRILFMLLSKLIGEIDYDLYLIIIDWY
                     ICFGAVLIILSALSSKLFSKLLLIKPVQFIGEISYSLYLVHPIVLLTTVHIFYGKISVP
                     LILLISFLFTMVVSVLCYKFIEIPSIKIGRKLATKNSRGDVSLRKKAS"
     gene            complement(22662..23843)
                     /locus_tag="EXW43_RS26435"
                     /old_locus_tag="EXW43_27000"
     CDS             complement(22662..23843)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002191261.1"
                     /locus_tag="EXW43_RS26435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_27000"
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_002184576.1"
                     /transl_table=11
                     /translation="MVIQAACFVLLAVIAIIVVIDFIPIGKNWLGRIKIGRYTDKSLWN
                     QSITHIGVKWLNKTPKIKVTDNTRLIAIDMLKGNYTKSAIQHWQEASLILGLSEYLKYN
                     DDRAVKHEITKFLNSKFDSNGQWVHKPQYVDGAILAYAIMKLDFEEIDKYKKALDATWE
                     MIQEHIGEDGTIEYRKFMKGYRYVDTIGFICPFLVTYGIRYNKSECIDLAVKQIKEYET
                     YGMLNLSHIPCHAYRLEDKVPLGLYGWGRGLGWFAIGLIDTWNELPENNGYKPVLEESV
                     REFAKATMKFQQQGNWNWTVTRNECGPDSSATSTLGWFMLNAAKIEDISKECLESADKA
                     IGYLMGVTRRNGAVDFSQGDTKDIGVYSKLFDILPFTQGFCIRLINLRNNYKI"
ORIGIN
        1 taccagtact aatggatgcc atatgttgga caatcatttc cgcaaatcgt tttgtagctc
       61 ccattacatt cgtcggattt accgctttat ctgtagaaac cattacgaac gtatttactt
      121 taaatgtatc agccgcttct gctacatttt tcgtaccaaa aatattattt tttacagcct
      181 cttcaggatt acgttccatt aaaggtacat gcttatgtgc agctgcatga tatacgatat
      241 atggttgatg cttgttcatt atttcaaaga ttttatgtcg atcttgaata tcagcaattt
      301 ctgtcgtaat ttccactgca tctttataag taactcgcat ttccatttca atagtataaa
      361 tgctattttc accatgtcct aaaagaacaa tttttgcagg attatacttc atcacttgac
      421 gacaaatttc tgatccaatt gatccgcccg cacccgttac taaaatcgtt ttacctgcga
      481 tcttttcccc gatgcccgcg tcatctaatt gaattggctc cctacctaat aaatcttcca
      541 cttgtacatc tcgaaattca ttaacagaaa ctttgccatc taaaagatct tcaagcattg
      601 gtacaatttg cgtttttgct ttcgtttttg tacacttctc aaaaatttcg tttatttgat
      661 ttctatttaa agatggaata gcaataatga tatgctctat atcattatct tccacaatct
      721 cttgaatatg atttgttgta ccaacaaccg gcacattata aatctccaat ttttgtttat
      781 ttctatcatc atcaacaaac gcaattggat atagatccgc ttctttatta tgttgcaatt
      841 gtcttactac catagttccc gctgaaccag caccgataat caatgttcgt tttttatctg
      901 tagctttcgt aatatatgta tcgcgaaaca tacgccatac aaagcgagaa ccaccaatta
      961 ataataaatg taacatccat gcgattgcta aaattcgaac ataaatatca tgatttataa
     1021 tttgttgaac aattgctgtt acaataatag aaagtgtaat tgctttaaat atttgtatta
     1081 attctccaac acttgcatat tcccacgcct tgttataaag cttataaata gccgcaaaaa
     1141 tatgatgact acacaataat gtaatagagc taataattac tgtcgcaggg attttgttta
     1201 atacattcgg atgtatgaac caataactta aatatacggc ggttaataca ataaatgaat
     1261 ctaataaaat taataatgag agccgttttc gataactcaa tatacctgtt cccttcttta
     1321 tataattcgc atcttattga taataaaaaa ggacattctc ttatgaatgt acctcttctt
     1381 tttttacaag ttcttttata tacttcatca agtctaattt caattcttcg ttttgaagtg
     1441 ccatctcaat cgttgtttta ataaatccga atttttcccc aacatcatat cgagtacctt
     1501 caaaatcata tgcaaacaca tgttgaattt catttaaacg ttgaatcgca tctgttaatt
     1561 gaatttctcc acctgcacct gtttgttggt cttcaaggaa catgaagatt tctggtgtta
     1621 atacgtaacg ccccataatt gctaaattag atggtgctgt tccctgtgct ggtttttcaa
     1681 caaatcggtg cacctgatat tgacgaccat tttgcgtgat tggatcaata attccataac
     1741 gatgcgtttc attttccggt actgtttgca caccaattac agacgaatgt gttgcctcgt
     1801 actcattcat caactgacgt aaacatggcg tatcagcttg tacgatatca tcaccaagta
     1861 atactgcaaa tggctcattc ccaataaatt tacgagcaca ccatactgcg tgacctaatc
     1921 cttttggttc tttttgtctt atgtaatgaa tattaatctt tgaagatgct tgtacttttt
     1981 caagcatttc atatttacct ttttctaaaa ggttttgttc cagttcaaaa gaatgatcaa
     2041 aatgatcttc aattgcacgt tttccttttc cagttacaat aataatatct tcaatgccag
     2101 attcaattgc ttcttctaca atgtactgaa tcgtcggttt atcaacgata ggtaacattt
     2161 ctttcggcat cgctttcgtc gctggtaaaa atcttgttcc cagtccagca gctggcataa
     2221 ttgccttcct tacttttttc aaatcaatac ccccaaaaat ttatatatac atatgtatat
     2281 aacaataata aaaaaaccta cctatagagt catatttata actccatagg tagagtttct
     2341 atcataaata aactatgggc atctaaccct acctcacatc atgctcccga cgacaagcgt
     2401 ctaaggtagg ttgaaatata atttctaccc acagcacgac cgagtgtccc cattgataac
     2461 ggttaggagg catcaccaag tggttttctc tttaaaagag accgaatatt tttctttgtc
     2521 ttattttctc gggctcttct cgataaatca tttttccact tattagttca tatgtatttt
     2581 ccttgaagtc gtacaatgta gaactcccaa atgttttctc tactgtttca tacgcagctt
     2641 gcaagtgaaa ggagcgcgtt gttgtgttat gagcatctga tgatatgaca tgtgttaaat
     2701 gatgctcaat aagttgcaat gaaaacttct tgattttctt tccgaacttt cctgtgacgc
     2761 ttcctgcggt aatttgtgtt agtgcccctt gattgacgag cttatacaac acatcggggc
     2821 gttcaataat ttccatattc cgttctggat gaacaataac cggcgtgatc cctttcacac
     2881 gtaattcata taacattttt tctgcatagc gcgggacatg gtttgttgga aattcaatta
     2941 atatatattt atccgtacga ttcaatgtaa caatacgcct cgaatcatag tcttctaata
     3001 actctccgta caacctgatt tcttgaccag gtaaaatggt taaattgata tcctcttctt
     3061 ttaatctttc atttaactgc tttacctgat gaagaatgct ttctgctaga ttcatataaa
     3121 ccccattttg gtgatgagga gtagcaacga ttgtatgaat tccttcttcg catgctgcct
     3181 ttgccattgc aatgctgtct tcgattgatt gtgctccatc atcgacatta ggcaagatat
     3241 gacaatgtaa atcaatcatt ctatttcatc ctctctccac atattcttca catactgaat
     3301 ataagaagaa aagatgaatg ttcacctttc cttcttttgc atttagttag aaccgtaata
     3361 gtaatattcg gatccatttt gttctttatc gtttaagaca acgccaagta atgtaccttt
     3421 tgcgctatct aatgattgtt ttgctttaag tgccgcctct ttttctgtta caccacttcg
     3481 aataacaagt acagaagcat cacattgatt tgccataatt tgtgcatctg taactggtaa
     3541 gattggtgat gtgtcaaaaa tgacaaggtc atacgtgcca aaagcttctg aaagtaaatc
     3601 tttcatcgag cttgcaccca gtaattccgc tggatttggt gggattggac cacatggtaa
     3661 aaatgttaaa ttaccgattt tcgtttgtgt cacacatgtt tctagtgtat tactacgtgt
     3721 taatacactt gttaagccaa atatattatc cacttgcatc atttgatgta atgctggttt
     3781 acgtaagtct gcatcgataa gtaatacttt cttaccttgt tgtgcgaaaa caactgcaat
     3841 attagcagcc gttgttgtct ttccttcact ttgattcgca gatgttacga taagagaacg
     3901 aatcttctta tcaacagatg caaattcaat atttgttcgt atatttcggt attgctctga
     3961 cacagatgat tttggttgtt catatgcaat cagctgacgg cgagcacgta atattttttt
     4021 cttaagaacc aattgtatgc ccccctactc tcttcgttgc tgataaacta ccgctctttg
     4081 tgccatcttc ctccatatga gaaacgacgc caagaactgg tacaccaagt tgtttttcaa
     4141 tatcttcttc ttttttcatc gtgttatcta agtactctag taagaatgca attccaacag
     4201 aagccattaa tccaacaaca aatgcaattg ctacgttcag catcttattt ggtttaattg
     4261 gtgactgtcc ttctgttact tctgcttttg ataagattgt tacgttatca acactcatga
     4321 tttttgcaat ttcactcttg aatacttccg ctgttgtgtt tgcgatatca cgagctagct
     4381 tttcatcttt atcttgtaca gtaacagcga tcacttgtga atctttctcg tttgcgacgt
     4441 taattttgct atttaaagcc ccagttgaca tgttaagctt taacttttct ttcacttgat
     4501 ctaaaataac tgggcttttc acaataactt tatatgtatt tgttaattga agacttgttt
     4561 gtacttcacc aggttgaaaa acaccttctt gcttcttttg attaacaaga atttgcgtcg
     4621 aagtctgata aatcggcgtt ataaagtaga aacttacgat cgcacttaca agtgctgcac
     4681 caatcgtaat tacaaggatc ataactaatc gtttccttaa aatagcaaat aactctttca
     4741 aacttattgt ttcttccatg ccttcctcca gctttcaata atttgtcata aaaacttcta
     4801 aaaaaaaata aattgttgga ttttaatctg acaacaaaaa tctgttatct agtcctaaag
     4861 ttgtttagta atagataact atttaatata ttacagaact tatattagta tagcaagaat
     4921 ggttgagaaa attgttggag gaattgacaa atactatact accgaatctg acgaatttcg
     4981 acacagtttt taatgtatag attttcattt gctatatact gtcgatatat gggtattatt
     5041 agtattacta gtgaatatat cattgattga tctgtgcatt tatactatcc tgtttataaa
     5101 aatattacca ttgttgattt ttattttgtt ttttcttaat ctttagatat ctttttcaga
     5161 ctttagttga taaacttttt tcgaaagtcc cctatttttt taatcaaacg tttgtttaaa
     5221 agtaagagaa cttacctatc gacaaatcct cttacctttc gtccatttct tcataattcg
     5281 cttcaataac aataaaaaag atgaatgacc atactctctt cattcatctt ccaacgtaaa
     5341 gttatgttaa caaatcttta ttctttctta tcaccaattg caaatgtgat ttcagcttca
     5401 caagcgattt caccatttac agttgctact gcttttcctt ttccaatcgg tccacggaca
     5461 cgtgtcattt cgacttctag gcgaagttga tcacctgggc gaacttgacg tttgaagcgg
     5521 cagttatcaa tgccagcaaa gaatgcaagg cgaccgcgat tttcttcctt cttcagtacc
     5581 gcaacagcac ccacctgcgc taatgcttct acaattagaa cacctggcat cacaggataa
     5641 tctggaaagt gtccattaaa gtattcctca tttaccgtta catttttaat cccaaccgca
     5701 cgctttcctt cttctacttc taaaatttga tcgactagta gaaatggata acgatgtgga
     5761 ataatttctt taatctgttg aatatctagc atatcattct ctccttatat accaaattgg
     5821 tcataccacc aacgcactgt ccttattatc ccattctcca ttgtttttgt cacgaaaaac
     5881 aagaaatgct ttctacccaa aatatctatt aggactattc atacaaaaaa gatacaccct
     5941 tttcccttcg ctaatcggta taacaaaata atagcaatta acacggaggt tggaaaaagg
     6001 tgtatatcaa agttagggag aggaaatata catcattttc ctcatatgtc gtattcatag
     6061 ctcattataa aggacaaaaa taagaaagaa aaatttaata tttactcctt tttaccatca
     6121 tacccttaat tttctacaaa tttctacaaa tttcttcatt tttcttatat tatcttaaat
     6181 agcatatcta gaaattaaga ttcgcaatcc agaacactat gctttataaa aaaataaatc
     6241 ttcgtggatt agcctttaat aaaaatccta taaaatatca tcacaaaaga tacatttata
     6301 ttttacagaa atatccaaca ttacatataa aatcttttaa atctatttaa caatacataa
     6361 aaataaagta taactaataa gaaattgttg cttttccttg tttatctgtt aaataaggca
     6421 ttcggagtat ttgagagaaa aactcaaatg aaataaaaag aaatacttat ataatattct
     6481 tcactatctc tctttcatct cctcaaatca tttcccttct taattactta tataaaatta
     6541 gtagcaattc aaaatactaa caattcatta ggcactacct ctcattaatc actgcccata
     6601 aaaacgtcta caaggtgctt caaaatatat tatcacaact acactaataa acctttatat
     6661 acaaaaagca gcgagacctc tagtcctaaa gacgaggggt ctcgctgctt tttgttatat
     6721 ggtataaata aaatcaggtt ccatgttaaa ttataacacg aatatttata catgtatata
     6781 gatggtatat taataagtca caaaagtatt tctaattttt ttactggtca cgcaattaaa
     6841 ttaagctcat atttccataa aaaaaccagt acacaaatac caattatccc tcaaaccata
     6901 aataatcaaa ttgtgttacc ggcccgaaag aaataaaggc agtgtattcc ttaaatttat
     6961 aaaaaacaat tataacaagt catatttaaa tgttaacttt ggcctgttgt ccaagtaggc
     7021 tactaaacaa accactttca tcttttgcca gttgtgcgaa actaccgtgt tgaataattt
     7081 gtccttgatc cattacaatt acttggtcag ctttacgtat agtagatagt ctatgtgcaa
     7141 tgacaataat tgtcatgctc cctttcaatc tttccaatgc ttcttgtatt ttcgcttcat
     7201 tttcagcatc taacgcactt gttgcctcat ctaacactaa aatagaaggc tttcgaagta
     7261 tcgctctagc cagaacaaga cgttgtcgtt ctcctcctga aagtttgact cccctatcgc
     7321 caatcagtgt atccaatcct tgcgagagcc tgctaacaaa ctcagcggaa gcagaaaatt
     7381 ccaaagcttc ccaaagctgc tcctcacttg catttggttc aaccattctc aaattgtctc
     7441 ttatactggc attgaataga aatggatctt gaggaacata gctaatagat ttcctcaatg
     7501 ataataggtc cttacttgtc aacggtttgt tatctattaa taactgaccg ctctccggct
     7561 gcataagtcc cattatgata tcaattaatg tactctttcc agcaccggaa cgccctgaga
     7621 tagctgtcat acaatttgca ggaatacgca aattaatatc tttaagtgag tacacagcat
     7681 tttctttatt gtagcggaaa gagatatttt gacactcaat agattgttct atctgcatag
     7741 gatttataca atcataattc tgctctatat cttgcaattc tatacttttc ttacactctt
     7801 cctgtaattg cagcaaatct ttaaaagcgg gaagattcgc tgcaatttgt tccatgtttg
     7861 attgtatacc tgcaaatcgt ggccacaaac gagaaaatat aagaataatt aataataatt
     7921 gctccgtttt cgtctgaaac agctgaacag atagaaagat aagaatagca atgaaaacag
     7981 ctgatgcaat tttataaaag agttgagaat tatttctcac cttaatatat gcaaactgtt
     8041 cacgttccac atcttctgcc caattacgta accacatata acgagatcgt tctagtgtat
     8101 tgctcttaat atccttaatt ccattaaaat gatcagttat acctgcaaga tacgcttttg
     8161 aattctctga ggttcgacca cctaatcttt ttgatttttt aataaatctt cgtgaaagaa
     8221 aggcaagtac cacagcgcaa catagtacaa aaattgttat atctgccgct aaccaaaaag
     8281 cgaaaccaat ctgtataaat gtaaacatta aagaagtgag caactgtaaa aataaattag
     8341 tgcctgcgct aacacgccct aattccgttg tcaaagaatt gataagatct gattttctct
     8401 ttttcacaaa gaaactccag ttggcctgca acaatccacg ataagtttcc aatctcaaat
     8461 gattaataaa acgtatctgg attttcgcat tacgaactgt tatattcctt tgcaaaagcg
     8521 cttgtcccac gaccaatata atatatattc ctaatacaag tggtaatcct aaagtagttg
     8581 gaatctcacc taggaatcca agaacccctg aaagaggact tgtctgttca ttcatcttcg
     8641 caataccgct aatacttatc ataggaatta ataataaaat gccgattccc tctacaagac
     8701 tgaccaatac cattcccatg agattaacaa tgagaatgtt tccagtgaaa gagtataacc
     8761 gctttgtaaa atataaaata tttctcattt tcacttctcc ttacggtacc tcatttccct
     8821 ccaaatccat aaaaccggcc gcaaagggaa atataaaaca tgcagttgtt ttggcagtgg
     8881 taaagtttcc acatcctgag gataaggata caaccaacta agatgaaaca gtagcttttg
     8941 agagcttgtc tttaacaaat ataaatatcg ctcatgatat tttgaaactt cttctgggac
     9001 aggatctgta tgcaagttaa tcatattttc caagtaatat atagcaagct gcgctaattg
     9061 cgttaccttt ctccctgaca ttaatacttt tgcctcttcc gctattataa gagtatctaa
     9121 aagctcagaa gataaaataa gcgcctgacc taccagtcgt ttacatccat atctttccaa
     9181 cataacagtg agttcttccc aatctatttc ttgccttacc atacggtcaa tgtccgttaa
     9241 ccatcgaagc ctggaccaac catgcctagt tccatgagtc acaagaaaca taaacaaatc
     9301 ctctctacct aaaaaataga caggataatt tgtgacagga ctcgtcctct ttcgccccca
     9361 tagctcatcg aagtgtggtt cctttcccgg ccctgggtgt agtcgccaat gaatctccaa
     9421 tttcacctta cttatcggat gcatgtaagt tgtatggtgg cgtctccact tccattcatt
     9481 cataaccgtc ggaaaatcat cctctttgac ataaccattc tttacaagta attcgttcac
     9541 ttttccaaga tcatctatag gaacaagggc atccagatcc cctgatgttc gaagggaaac
     9601 atctccatat aggtctgcgc caagaatagg acccttcaaa aatagaagtt gaagttggtt
     9661 ttcagcaaat aatttactca cttttcccat ttctccactt aaatgaagca tatggaatgt
     9721 attcctttta aaatatgtac ttaatacttg cacaacattt gatggaacta actgtttatc
     9781 aatagatttc atttttgggt aaatgaacgc gtacatgcga tgatgcagcg ccagtttcaa
     9841 aaatttgttc caatcaatat ttatgaacca gtctcccggg atttcttgta tctctttatc
     9901 ttccttcttt ataatttcaa gtaacaattt tagttcttta ggtaaatgac tcaaatcaag
     9961 attacaaccg gtatacatct cattctcctt caagattttt ttaccctatc ctttttgcaa
    10021 atttaccaac aacggtaaat ctcttcattt cttctacgcc agtaatataa aagggcccgc
    10081 tacgtaacca cgcatgggca atcatatttc ccgtctcatc tttcgcggtc cctaagtaaa
    10141 gggtactttc aatttgacgc ttctccaaca ttttcattgc agcgatagct ttaacgagac
    10201 actggctttc ccaaaatgta taacggctca tcatatgcac tgcttgagaa attttcctta
    10261 acgtaatctt ttccgattca tcatagctta aagacgtttc tgccatatga attcctaata
    10321 taggagcagc tttagaaaac ggtatacttt taagaatacg agcccagcct aaataaaaga
    10381 aagcttctat aagtaataat tttgttccca tatcgaacga caagaaagct ttggctttat
    10441 ttatgatatt catcgattct actcctaatc tattaaatct ggaacgttca attaaaaatc
    10501 aaagtttttc atcaaccgag attaaccctt ctgcatacaa atgatttaag aaagagagta
    10561 cttgttcctt acattctgcc tcttcaatca tatatcgaga caataatata tcgatcactt
    10621 gattgacaga tattaattca ttaattaaac tccaaatttc accacctata cctcctaagt
    10681 tatagtattt cccattatgg atgctcatca tcactttctc cccatccata tcgctcacta
    10741 cattttcctg accttgtaca acaaaactgt gtaatgaaat tgtttgttta ctactcatta
    10801 tttttcctcc tcttttaaag actctagaat tttggatact aaatcatgtg ccgtaaactt
    10861 tgaaatagga cgtctcaatt gaaacatatc tattttgttt acgatatttg ttgaatgcat
    10921 aaaatgccat tccatcatcc ccaatcgtgg gattaatgaa ttcctatatg tatgacgtag
    10981 caatgtgcgt agtctctcca gtccttcaat ctgctgaagt tcaacatccc cattttctac
    11041 tttcactaac tcgaatacac ctgccaatgg taatggttcc tcgaaaaagt tagctgtaac
    11101 ggggacagca tatttagttt ccctttcaaa taatggctga taatgcgctg tctccattcc
    11161 aaactgatca agactctctt tccataactt ttgttgcggg taagatggtg taacaaaagg
    11221 agtattatcc tcagaaagag acacagcaat tacatcatcg ctcaaaagct tatagccttt
    11281 gcttaaaagg gctgatgcaa gagttgattt tccagctcct gatcttccta caaaagcata
    11341 cgcctttcca ttgatggcta ttacacttcc atgcagaggg agtatttttc tctgcatcaa
    11401 caatgccccc atacaagtcc caagaatata aagccgaatc ttatcttgat cagacccttt
    11461 cataggtgaa acaatgattt tttctccatt ttgaatacaa aacgtagcag tttcggggat
    11521 ttgaaacata attaattctt cttcaactac aaacactgac ttcggagaag ataactctcc
    11581 ccataattgg gacaaatctg cagtttctat ttttacgtct acttcatttt cgtaattact
    11641 tacttgaggc aattccggca ggggaatctc acttaatagg gctaatccga aggctttgta
    11701 aatctctttc tttacagtat gtatcatctt tctcactcca aatagttgaa aaattgatta
    11761 aaaaaaccct tataccgtaa ttaaactata taagggctgt aaagcatata aatcttattt
    11821 aaatattagt gcattagctg tggtgaagag cgccttgctc atcctcatct tcaaaaactt
    11881 ggtcaacaag tctctttcca ggtccagcca ttgtcatgtt gatatcaagt acttctaata
    11941 ctggtgattg ccattcttgt ttcataattt cacccccttt caaatatatt ttttgataaa
    12001 tcgatagaca ataagactac gcatcaaaat tctaaaatct ggatcaaaca cgtattctac
    12061 tcgtggttct ccttgaattt tcaaaatcgc gctcttaata atctccatat taaaaaagtt
    12121 agaggccact gggtctttac taagctgctg aagttcctcg ataaacattt tccatgaagg
    12181 aatcatgcga tgaaccacat cagctgcctg tattccccgc acacgctgat ttaatcttac
    12241 tttgtcagga agaaatcctt ttgtggacct ccggacaagt gcacgattta agccattttg
    12301 aacaaattgt tcgagtggta acgataaaca gaatcgaatt acccgtaagt cattcgttgg
    12361 atcatgccct tgtaaaccat aacgcaagga gagctttgtt ccacttgtac ccgttgtatt
    12421 ccacaagttt agctgttcaa aatgtttctg ccttatttca tatatatttg ggatagaagc
    12481 ccctgttact ttcacaccat gttcttcaag ctttctaaat acatcagtac gttttgcaag
    12541 ttctggacta actaacgttg gcagttcgta ttgctgttcc gaggaaaaca tgttttttat
    12601 cgatggaaat gctttctccc ctataacttt cagtattctc gattttttga ccccaacgtt
    12661 cttaccatac aaatcaattt cacgataaag ctgcaaccag ctgaactttt taagtaaaat
    12721 cgcataataa tctaaagctg gcccccaaga gattgtgaaa tttcctctcg ctccatttaa
    12781 gagcacccca atcccttgtt gttgggcttt ttcataaatt cctttcaccc agacggaatt
    12841 ttcgaaaaat ttatatggca tctccataat ctcaagccaa tcatcaattt ctgagaaaga
    12901 attttctccc ggaaaattca aataattccc tttaatattc cctacatgtt gtactgtagt
    12961 ttgaataaat ggcttttcat cagcaatcgt atgaccacga gtccaatcag taaacccttc
    13021 cgcaggtact gagctgaatg tatataattt tttgttctct ttttgcaggg ctctcgcggc
    13081 aaagctagca acagctcctg aatctaatcc cccacttaaa tgagaaccaa cattacgatg
    13141 agtacgtaac cttgatgtta ctgcgctttc aaatacgtcc ctgaacgcct cttcataatc
    13201 ttcatttgat ttgagttgca actgctcctc tacaaataac gtgtcatatt tcgcaatact
    13261 aactcttccc ttaactacgg agatagtatg agaaggcggg acttgctcta tatttttatg
    13321 cactgttgaa aatgcgtcta ttgtatcaag catattaggt atcgctaaat attcagctaa
    13381 ccattgctca ttcaattcct tcccgacgta cggtaaagaa aacagcggct gtatgctagt
    13441 acaaaaagca aattgatttt gattgcggta aaagtaaaaa gtccgacttc ctgaaaaatc
    13501 acgtgcacca aaaagcaatt gctttctctc atcccaaatc ataaaagtaa aatcaccaat
    13561 tagatacttt ggtacatgct ctccccactt ttgataagcg agtaaaatca acttactatc
    13621 aggcatctct cttctatgta ccttgtctac ttgcaatcta tcgaataatt cattgcgatt
    13681 atcaataata gcatcagcag ttataaccaa ctgtgtttca taatcatagt aaggtaattg
    13741 ttcattaata gattcagatg ttatccattt tgcatgggag ccaaaaaaaa tattttcctt
    13801 gtgccatata tcggtattgt cacctggata acgagataaa tctttcatga ttccaatcct
    13861 atgttcaggc ggtatcggtt ctccatttaa atggtaaatt ccggttattg cactcatttt
    13921 ttcctcccac tacgagacaa ttaagggaaa acccaatgga taagcaaatt actagatata
    13981 tcaaaaaaat gttattaata taccagaaaa ccctttcctc aaactacctc atttacgcat
    14041 aacagatttt aaaacccaat tttatagcct taaatctttt ttcagttgaa gtattcaagc
    14101 tttcaagcta cctatcctat tgtaaaccct cgcattttaa ttttctcaaa aaaagaacaa
    14161 aggtgtgatt ttcttaattc gaatcaaaat attaccatct gaattttata taaataaaaa
    14221 tcactgaatt taatatatca ataaaacgtt tatattcttt ataaagaata taaactcaga
    14281 ttaccatttc actattgcat tgtcaagtat ctatatactc aataaaacga atatttatgt
    14341 atctttttta gtaactgtaa gaacaaataa tacagtaaaa ctttaatcgg taggaggctt
    14401 tacatcccta ccgactatta atctcaccaa tcgagctttt acgaacattc catctatttt
    14461 cttagtttcc ctaaaatctt aaggtagtgc tcttaatact cataaatagc aggataaacg
    14521 ttatatctta caaataaaca ggagaatttt catcttttta tatttttaaa atttctgtgc
    14581 tatgatattt tatataattt attattaacc cactaattaa agttgatttt tcacgtgtta
    14641 tgttctctat tactttattc tcctgcttct ttaatcgaaa caggagaata acctttttat
    14701 atttatacca ttttcacaaa ggggatgata taatatgcgt ttaccactaa taaaaaatac
    14761 catccgcatt taccataaga ttatgtacgc ttactatttc actctttata gggattgccg
    14821 tgactttcat tcaaagaaaa ttttttttag taaaatgaga tttcacaaaa acagcactga
    14881 atgagatatt aaatcctcct agttcattaa cacctttctt aattaaagct gtttctattt
    14941 tttatcttta catgccagca cttaccatca atatattctt aatacatgta ataactcttg
    15001 tctgattttt ttctgtcata cctgatccag acggaaggca tacgcctgtt tcaaataatt
    15061 ttctagaaac atcctcaccc tcactatgcg gataatacat tacatcttca aataaaggtt
    15121 gcatatgaag aggcttccaa acaggacgcg cctcaatgtt ttcattttcc agttgtttca
    15181 gtaatgcctg aatcggtact cctgtttttt cttcatctac agtaagaact gtaagccacc
    15241 ggtttgaata agtatcctct aactcaggca taaactgtat ccctggaata tgagataatt
    15301 cttgataata tctatcgaat attcgtcttc ttgcatgtac tctctcttgt aagacctgca
    15361 gctgtgctct acctacacct gctaaaatat tactcatacg ataattatat ccaacctcac
    15421 tatgttggta gtgtggagcc ggatctcttg cttgagtagc taaaaatctt gcttttctca
    15481 atgcttcgac atcatccgaa acaagcatac ctccacctga ggttgtaatg attttattgc
    15541 cattgaatga ataaacaccg aatttcccga atgtcccact cgctttacct ttgtaggaag
    15601 aaccaagtga ttccgctgca tcttctacta ctggaacatt atatgtatta cataacgaaa
    15661 gaatctcatc cattttagcg ctttgtccat atagattcac aacaatgaca gctttcggaa
    15721 gtactccttt ctcatttgca tcacgtaatg cacgttctaa agcttgtggc gacatattcc
    15781 acgtttcaag ctcagaatca ataaatactg gtttagcccc taaatataaa attggatttg
    15841 cgctcgctat aaaagtaagg cttgaacaaa acaccgtatc tccatctttt acatccagta
    15901 agcgaagtgc caaatggata gcagaggttc ctgaactaac tgcagccgca tcaagaactc
    15961 caacatggga tgaaagttca ctttcaaacg catctacatt tggaccaagt ggagcaatcc
    16021 aattcatatc aaatgcttcc cctatatatt tttgttcatt accgctcata tgtggagcgg
    16081 agagatagat tcttgttttt tcctgtgagt ataccacttt aaacactctc ctataattct
    16141 ttgtttatta ctctagctgg aataccaact gccttacaat tcgctacaat gtcacggatc
    16201 actgttgctc cggcaccgat aacggaccaa tcgccaattg taatatttgg aatcacatta
    16261 actcctgctc ctatatgtac tcctgttcct acagtaacgg atcctgtaag cactgcattg
    16321 ggggaaatat gtgcaaaatc atttacctta ttatcatgtt caataatagc gcctgaattg
    16381 acaataacgt gattcccaat tccaacatct gcattaacaa ttgcacctgg cataataacc
    16441 gtaccagctc caatctttgc acttaaacta acaatagatt gtttatgtat aagcgtcgca
    16501 tagcgatgac tgggaatctc taactgctcc ataattatct ttcttgttct gttattccct
    16561 atagctatca cgaactttgt atctacatgc tcatccatta actttacagc tgcagaaata
    16621 ggtccaaaat aaacaccatc ctcaattttt aactctttat acacatcatc taattgcgca
    16681 atgatttcat aatttccata cgataggata atatctcgga ttactttact atgaccacct
    16741 gccccaatca taattattcg catccatctc acctcctcaa gaattctttg taccattaaa
    16801 tttttccaca gttacatgcc caacctgatt gattccttct gacttaaata ctttctttgc
    16861 cgttaacaac aaaattttca tatcaagcca aaaagtccgt ttttttgcat accatacatc
    16921 aaaatcaaat ttttcctccc aagaaatcgc gtttctgcca tttacttggg cccatcccgt
    16981 aatccctggt ctgacattat gtcgcttggc ctgctcttct gtgtatagtt ccaaatactc
    17041 catcaataat ggtcttggac ctaccaaact taagtcccct tttataacat taaacaactg
    17101 tggccattca tctaaactat attttctcag aaaccctccg aaacgggtaa accttacatc
    17161 atcgggcaac acattcccct cactatcctt ctcgtcagtc atagttctaa acttataaag
    17221 aaaaaaaggg acaccatgca atcccgggcg ttgctgctta aatatgatag gggaacccaa
    17281 cttaattcta actaaaacag ccactattat aataagaggt aaaagaaaca ccaataatga
    17341 caaagaaacg aacaaatcga aaagtctttt catatataat catactccta atttggttta
    17401 tgtattaacc tctactctat aactgcctaa aacttctatc ttcataaaaa gcagccccat
    17461 tcatagttga aaaataacga attgatttac ttttttattt agggacatgt catgcaaaat
    17521 atttaattaa aatactcagt aataagaaca ccaccatatt caacagaaca tagtggtgtt
    17581 tcatttctaa aagattctta atattttcct tttatttact tgctcttact ttaaagcatt
    17641 ataattttgt gtcaattcat taggcgctgg tgctcgatgg attgggttag taacaggatt
    17701 atagaaatgt agatttcaaa ttaaaaagtg ccctttttgt ttgactgaat tttcaccctc
    17761 aggtttccca ttatactttt aacaactcca aataaatact taaattcatc tgtcttataa
    17821 aaaacaaata cataaatagt atttggaatt attaaacaaa tcatccctct taatattaat
    17881 tctagtaatc cattatacgg aataagacca catattaaac ttgtgataac acaagctcct
    17941 agccctatca tcacatagta agtatatttt aaaaaataat ccctaaccgg tttacggaat
    18001 actttcttat atactaaata aggagcaatc caaaatggaa ccactagtgt acttataagt
    18061 gttccaataa aaacacctgt tatgcccata tattgcacca agacaataga agccaccaga
    18121 ttcacggcag cctctaaaaa gggcgcatac ctatcttcat gaaaaatccc tgatgttgtt
    18181 ttgaccatag atatagagcg tctcattcct gatacataaa aattcatcat taatataatt
    18241 aacacactta tatccataat aaatttcgaa ccaatccata aagtaataaa gggttgcatt
    18301 ataatatata aaaatatgga aaaaaatgag tatatccaaa aattacaaag catagtaatc
    18361 ttaaatatac tataaatttt ttcatcgctt tcttttgcca ccaaattccc tacactatga
    18421 ttaatattat caaatatttg atttataaag gttctacaaa tgttaattaa catataataa
    18481 tttgaataca atccaacagc tgtaacactg acaaaagacg caattaacat gttatcagta
    18541 ccaaagacaa tatatccacc tatattatgt agcactaaag cctttacatt tttaacaata
    18601 ttacttttgg tttcactatc taatttgctt gctgctttat tttttaaaaa tgggtacatc
    18661 ttatctacca atatagccaa gaacgcagag gtactgattg ttataataat atcgattatt
    18721 agatataaaa tataactatg cgtaaagtat aaaattccta ttttaatgca agtagatata
    18781 atagatgaga tagaataaat ccctgtaaca atatatccct tttgacaaac atttaaaaat
    18841 gaggttttat aagaaaatag ataagatgaa gctgtattaa ttaaaaatat aatataaata
    18901 aaatgaatat tgtctacctt tgcatcttta gcgatatatc caagaaaagg taacaaaagt
    18961 aatcctagta acaatactat taaagctatt gccatatatg cctttctata aaaattcata
    19021 agcatattga ttctatcctg attattttct gccactggtt tatatagatt atatatgata
    19081 gcagatccta ttcctgcttc agctaaagat aacattccta atatattagt aaataatcca
    19141 tttaccccca gatactcaac acctaaataa gtaataaata tggttctgga agcaaaactt
    19201 agtaacgtaa taataacttg actacctata ccggctgata tattaattat tgaattttta
    19261 actctcattt ttcctcccac ttcagaaagt atgaaatcac tttcaaccca cgagcattac
    19321 ctgatttctc ttttatatgc tgcaactatt aaaggataca ctttaaactt tattgctaaa
    19381 taatatatat actccttaaa gttattgcat cgatatgaaa aaccaattcc ttttacacta
    19441 tctgagaaca tttcataatt cactattcta cgaaaagcat tattaacatc cacattaggg
    19501 gcgcttttta aattattaat caagagtcta tatatgtgat ttatataata attagccata
    19561 tcttttttaa attgcttatc gtgtagtaaa ccaaattctt gtgaaagttg tcttctcatt
    19621 tgatattgta aaactaaact gttctctaaa tttggtttat acggaaccct cattaagcta
    19681 tttggattat taatagtata aaaataaaga acttctgaga ctgcacatac cctttgtgag
    19741 tgcaataaaa actctaaatt aaaaataaca tcttctccaa taaacacttg ttcattaaat
    19801 ctgatgtttt cttcttttat aatgcttaaa ttgtatatat acctccatgc aaagcataga
    19861 tcattcttgg aatgaacatt tggagagctc agtacaaaat ctctcccgtt cataacagta
    19921 tctaatttga agttaggaat aatactatta ttatttggaa cagttttgta tccgcatatt
    19981 acagcatcac actttttatc ttccgcaata ccatataacc tagtaaaata gttttcgctt
    20041 acctcatcat cgggatctat aaacactata tacttccctg tagcagcctc gatccctgca
    20101 ttccttgcgc tactcactcc tccattttct ttatagatta ctttaattct attatccttt
    20161 tctaaatatt cttcacatat ttcaccacat ttatctgttg aaccatcatt gactagaact
    20221 aattcaatat tgacgaaagg ctgttttaaa acactttcaa tacatctagc taaccatttt
    20281 tccacattat atatgggaac aataacactt attaattcat gcaatccttt cacctctaca
    20341 ttacttacat aagttaaacc ctcatgccta tcttattaca gctttaattt cacttaaata
    20401 tttctcatct tgaatatcgc ccacattttg tccagccccc gcttcacata cgtacttatt
    20461 ttcaattttg attttagttt ttgcttgtct taaaaaccat tcgtattcaa tatccacatg
    20521 ccctatatca attgcttgat atccctcttt atacaaatca tatgctaata tagtagcagt
    20581 aggccctatt gctaatagaa tcaatttaga tttattattt ttttttgctg ctgttaagat
    20641 gttattgtaa tgtaagaatg cgtgctcctc tggtactaaa atcctttcaa ttgatttagc
    20701 attttcaaac agatcatttc caatacctaa tctactctta ctaccctcta ttaaaactat
    20761 atccctatct ttccatatta attttaataa tataaaccat tctttacatt ttgacttatc
    20821 tcgaaaggga taatagaatc tcgatataaa ggaattataa tatacttttc ccttcttcaa
    20881 gtctttatac cactttaatc tatattttgc agtatgaaga ctccaataat cctttggttc
    20941 atctgcatat tttgataaat cttgaaaaac atccggcaaa caaactaaga acttctcatc
    21001 ttcacttagc aatatttctt ttaatctttt tgataacaaa tgatcagccc gttgaaatgt
    21061 tatatctaga ttatgaatta atttaaattc accatcacca tacctggcta cggaagcttt
    21121 atcatgaata atttttttta aagtttcatc tatagattga attctagggg gcttgaaaaa
    21181 gcacttcgtg aatcgatctt ttatgatagt taatcgattc aaactctgaa ttttgatatc
    21241 gatccattta ttccaaataa aaactaacat actttttatt tttatttgca ccataccaag
    21301 ctcctttcta atacttttct cgatagagca ttagattatc tttcctcttt ttcttaagaa
    21361 aattactctt atccctctat tcacatctta cataatattt attcttatta ttttccaatt
    21421 tttcaactag ccttttttct caacgaaaca tcgcctctag aatttttagt ggcaagtttc
    21481 cggcctattt ttattgatgg aatttcaata aatttatagc ataagaccga cacaaccata
    21541 gtaaataaga aagaaattaa taaaattaaa ggcactgata tctttccata gaaaatatga
    21601 actgttgtta atagaacaat tggatgtact aaataaagac tatatgatat ttcccctata
    21661 aattgtactg gtttaatcag taataattta gaaaatagtt ttgaacttag agcggataga
    21721 ataattaaaa ctgcaccaaa acatatatac caatcgatga taataagata caaatcataa
    21781 tcaatttcac caattagttt ggaaagtaac ataaatagga tacgtggata gctaaaaaat
    21841 aaaagaccta aaggcaataa tatatatttt acttttgaat taataatttt actcactaaa
    21901 tattctctgt ttttggctag tagtgcacca ataataaaca ttgagctata atgtaatgtg
    21961 ataaagtaat tggtggatac tggcatatta aattcgcttg gaatgttctt cattaataaa
    22021 taaccaataa ctgataaaaa catcgctatc ccaatactta ctttccagtt tactctaagt
    22081 aaaagaaaaa taattaaagg aaacactatg gaaattcgca tctcgtgaac taatgaccaa
    22141 atcaccataa taaacgcatc agaattaaat tctctcaaga ataaaatatg atccattact
    22201 ctattaaaag aaacttctat gttccatgaa ccccattgta ccaaaccagg aatggtacca
    22261 attttagaat gaatccccaa tttaattcct attgcaataa aaagaatcac aatataagga
    22321 atgtaaatcc tacaaactct tttaataaga tactttaaat aattaaattc cgtcccttta
    22381 taaaaaggca aggatagaac aaatccactt aacacaaaaa atataataac agccgaatga
    22441 ccttgccata atatagaaaa ataggctcca aatgttgaat acattacctt tttacctaat
    22501 atcggaaata atgctaagaa gtgtcctaat agaacaatga ttgcagcaat accccgaagg
    22561 gaatccaatt ctttataacg tctcgtcata attcttccct ctgttctaaa ataaaattta
    22621 ttaatctgaa tattgaaatt tagtcatcct tataaggatg actaaatttt ataattatta
    22681 cgtaaattaa ttaatctaat acaaaaccct tgtgtgaatg gcaatatatc gaataactta
    22741 gaatatacac ctatatcctt cgtatcacct tgagagaagt cgaccgctcc gtttcttctt
    22801 gtcactccca tcaaataacc gatagcttta tctgcacttt ccaaacattc ctttgaaata
    22861 tcttctatct ttgctgcatt caacataaac caccccagtg tggatgtagc ggaggaatct
    22921 ggtccgcatt cgttcctggt tacagtccaa ttccaattgc cttgttgttg aaatttcatc
    22981 gtagcttttg caaattcacg tacactttct tctaatacag gtttatagcc gttgttttct
    23041 ggtaattcat tccaggtatc tataagacct atagcaaacc atccaagacc tcttccccag
    23101 ccatataaac ctaggggaac tttatcttct aatctataag catgacatgg tatatgactt
    23161 aagtttaaca ttccatatgt ttcatattct ttaatctgct ttacagccaa atctatacac
    23221 tcacttttgt tatacctaat gccgtaagtc actaagaatg gacatatgaa accaatagta
    23281 tctacgtatc gatacccctt cataaacttt ctatattcta tcgtaccatc ctcacctata
    23341 tgctcttgta tcatttccca ggtagcatcc aaagcttttt tatatttatc tatctcctca
    23401 aaatccagct tcataatagc ataagcaagt attgctccat ctacatactg aggtttgtgt
    23461 acccactgac cgttagaatc aaatttggag ttcaaaaact ttgtgatttc atgttttact
    23521 gctctgtcat cattatattt caggtattca gacaacccta atattaaaga tgcttcttgc
    23581 caatgctgta tagcgctttt cgtataattt cctttcaaca tatcaattgc tattaatctt
    23641 gtgttatcag ttaccttaat ctttggtgtt ttatttagcc acttaacacc tatatgagtg
    23701 attgactgat tccataagct tttatccgta tatcttccta tttttattct tcccaaccaa
    23761 ttctttccta taggaatgaa atcaatcact acaataattg caattacggc aagtaacaca
    23821 aagcacgctg cctgtataac catataatta tgtcctttct atactactta aataatgtat
    23881 ataatttttt tatctccgac tcggttccta gctcttc
//
