LOCUS       NZ_CP036117            25238 bp    DNA     circular CON 12-DEC-2024
DEFINITION  Bacillus mycoides strain JAS481 chromosome, complete genome.
ACCESSION   NZ_CP036117
VERSION     NZ_CP036117.1
KEYWORDS    RefSeq.
SOURCE      Bacillus mycoides (Bacillus weihenstephanensis)
  ORGANISM  Bacillus mycoides
            Bacteria; Bacillati; Bacillota; Bacilli; Bacillales; Bacillaceae;
            Bacillus; Bacillus cereus group.
REFERENCE   1  (bases 1 to 5296574)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5296574)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 187.86x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018741645.1-RS_2024_12_12
            Annotation Date                   :: 12/12/2024 04:46:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,189
            CDSs (total)                      :: 6,036
            Genes (coding)                    :: 5,734
            CDSs (with protein)               :: 5,734
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 302
            CDSs (without protein)            :: 302
            Pseudo Genes (ambiguous residues) :: 0 of 302
            Pseudo Genes (frameshifted)       :: 122 of 302
            Pseudo Genes (incomplete)         :: 192 of 302
            Pseudo Genes (internal stop)      :: 81 of 302
            Pseudo Genes (multiple problems)  :: 78 of 302
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:51:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2481478
            Orig. end                         :: 2506716
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036117.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25238
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="6"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25238
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25238
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15238](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15238
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    753..766
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.02"
                     /tool="antismash"
     gene            complement(965..1534)
                     /locus_tag="EXW43_RS13055"
                     /old_locus_tag="EXW43_13395"
     CDS             complement(965..1534)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="EXW43_RS13055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13395"
                     /product="hypothetical protein"
                     /protein_id="WP_003189353.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPSTSVFAAEKEAPIQQEEIQMSI
                     QPFAQNNLETAVKAALNGPEVKKIKVFEHEFNVKPIEVVNLGGGKTYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFTAPLLSILAAYNGIPVNPNDLNALGQQ
                     IGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    1861..1874
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(1982..1997)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    2072..2090
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.89"
                     /tool="antismash"
     gene            2135..2977
                     /locus_tag="EXW43_RS13060"
                     /old_locus_tag="EXW43_13400"
     CDS             2135..2977
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="EXW43_RS13060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13400"
                     /product="metallophosphoesterase"
                     /protein_id="WP_002032218.1"
                     /sec_met_domain="Metallophos_2 (E-value: 6.9e-09, bitscore:
                     34.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIKRIILIIGILVGISIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKVKSINPDIIAITGDLIDSKSYDAEMSMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKKLKKQHVTVLRNEHVIIQKGGHEINLLGIDDPEF
                     NTGDIDEGSIVKDAIVKAKIETLPDRYNVLLSHRPEFLEAYADEQVDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGILPKYTAGLYEQQNTSMIVSRGLGNSIIPQRVFNRPEIVVVQLN"
     gene            3194..3445
                     /locus_tag="EXW43_RS13065"
                     /old_locus_tag="EXW43_13405"
     CDS             3194..3445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="EXW43_RS13065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13405"
                     /product="hypothetical protein"
                     /protein_id="WP_002017002.1"
                     /transl_table=11
                     /translation="MHKEFEIEEYTAIEEQIHYYSTSLLVSHPEQIVKYLEKRLEKYAE
                     TLQYAHLYPETVILPIQQIVIEYSLDVARIRRYLNLKT"
     gene            3630..4355
                     /locus_tag="EXW43_RS13070"
                     /old_locus_tag="EXW43_13410"
     CDS             3630..4355
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129461.1"
                     /locus_tag="EXW43_RS13070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13410"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_059038321.1"
                     /transl_table=11
                     /translation="MQQPSIILRDVSKKFRKKEVLHNLSLQVEKAEIFGLVGPSGSGKT
                     TLIKMIAGINESTTGDVIVFNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKERIVEVFEFLQLSDHAKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKSIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAIGTPEELKK
                     QTSSGRIEDVFMLEGVIES"
     gene            4352..5371
                     /locus_tag="EXW43_RS13075"
                     /old_locus_tag="EXW43_13415"
     CDS             4352..5371
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="EXW43_RS13075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13415"
                     /product="ABC transporter permease"
                     /protein_id="WP_002127488.1"
                     /transl_table=11
                     /translation="MRVNGVVIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLIFTQKDYI
                     PHIAVVDVPAPIVKAMKNQEASIYEYSKDKAISELEKQKVDAVIHLENGKMNLLLEGSD
                     SSKNRAVLQVLQKSTEKNNVSMMKPEVDYLHGSKDITMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVLGYIIGFGIFALIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQVFFSGLFPMESMNTW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            5396..6049
                     /locus_tag="EXW43_RS13080"
                     /old_locus_tag="EXW43_13420"
     CDS             5396..6049
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="EXW43_RS13080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13420"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002032224.1"
                     /transl_table=11
                     /translation="MKKDWLEELVAATNADKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLFAVVMPTLTKFAAPFFVQAFAKEIFKTEYESYEVLL
                     RVIIQNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLIETELLVHFKKLIAKFQEEGE
                     IIELPPSSVLRLTLSAVLGLLLTRFLLLPEEKWDDEVEIENTIQFILYGLTPRR"
     gene            6054..7022
                     /locus_tag="EXW43_RS13085"
                     /old_locus_tag="EXW43_13425"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="EXW43_RS13085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13425"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_002127490.1"
                     /transl_table=11
                     /translation="MRQFAKPIIVVSKCLEFDACRYNGEMVPDLTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEKNGANRLVQPSIREDVTEKMNEFSNAFLQTLPEVDGFILKN
                     RSPSCGTRDVKIYSGFEKGPVKGKGTGLFGGAVIKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAHYKMIKHTKNIKELVAFQSDYKYLFMAYNQVKQKELGRIIANQKNETIEVVFD
                     NYEKTLYELFIRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLELLQKYSEKKIPLSSL
                     LVILKTWAIRFDEKYLLRQTYFEPYPEGLVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="EXW43_RS13090"
                     /old_locus_tag="EXW43_13430"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="EXW43_RS13090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13430"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_002032227.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.2e-39, bitscore:
                     131.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.7e-26, bitscore:
                     89.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.7e-57, bitscore:
                     192.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTLSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKFLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGFEDNGKKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKPISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERYIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="EXW43_RS13095"
                     /old_locus_tag="EXW43_13435"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="EXW43_RS13095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13435"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_003189363.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.1e-10,
                     bitscore: 39.6, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.3e-06, bitscore:
                     26.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1e-06, bitscore: 26.7,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2e-09, bitscore: 35.5,
                     seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKLA
                     NEAYLVGGPRVQESYLNLEKIMEIAKKTNAEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEDTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPTNIRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LKIALEELKVEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     misc_feature    8443..8457
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.62"
                     /tool="antismash"
     gene            9764..9979
                     /locus_tag="EXW43_RS13100"
                     /old_locus_tag="EXW43_13440"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="EXW43_RS13100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13440"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001985297.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="EXW43_RS13105"
                     /old_locus_tag="EXW43_13445"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="EXW43_RS13105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13445"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_002017011.1"
                     /sec_met_domain="HMGL-like (E-value: 8.6e-49, bitscore:
                     164.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADASDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALAVIEDITKQATFEGKKVRGYVSTVFGCPYEGDISATAVDEIC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="EXW43_RS13110"
                     /old_locus_tag="EXW43_13450"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 4.4e-75. Score:
                     244.1. Matches aSDomain:
                     nrpspksdomains_EXW43_RS13110_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="EXW43_RS13110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13450"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_002017012.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRERQANSLSLALLEELQTILTQI
                     NEESNTRVVILTGDGEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW43_RS13110_ECH.1"
                     /evalue="4.40E-75"
                     /label="EXW43_RS13110_ECH.1"
                     /locus_tag="EXW43_RS13110"
                     /protein_end="254"
                     /protein_start="14"
                     /score="244.1"
                     /tool="antismash"
                     /translation="HVVKISLNRERQANSLSLALLEELQTILTQINEESNTRVVILTGD
                     GEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="EXW43_RS13115"
                     /old_locus_tag="EXW43_13455"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="EXW43_RS13115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13455"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_002017014.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLITPQEPKQFDKTLEEIIPENQNAPFNM
                     KDLINRIIDEGSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYRLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13298..15238
                     /locus_tag="EXW43_RS13120"
                     /old_locus_tag="EXW43_13460"
     CDS             13298..15238
                     /NRPS_PKS="Domain: AMP-binding (95-521). E-value: 2.6e-82.
                     Score: 268.5. Matches aSDomain:
                     nrpspksdomains_EXW43_RS13120_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="EXW43_RS13120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13460"
                     /product="AMP-binding protein"
                     /protein_id="WP_003189366.1"
                     /sec_met_domain="AMP-binding (E-value: 3.5e-87, bitscore:
                     290.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLFGWMKSLGYEDYEAFYNKSIEETAWFW
                     GEAERAVGYQWMKPYTEVLDLENGTPFAQWYTEGTCNVVESALSRWLADDKTKTQAALM
                     YEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFNTVGKGKVPICNYSGGTEISGGIFGNVLIKSIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAVGVPDDVKGEVCHCFVVLRDGVTFSGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13583..14860
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW43_RS13120_AMP-binding.1"
                     /evalue="2.60E-82"
                     /label="EXW43_RS13120_AMP-binding.1"
                     /locus_tag="EXW43_RS13120"
                     /protein_end="521"
                     /protein_start="95"
                     /score="268.5"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KTKTQAALMYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGD
                     RVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRR
                     GKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNS
                     DDPLMLIYTSGTTGKPKGTVHTHAGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPF
                     LLFGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNK
                     HSLKSLEVFASTGEPWNPDPWMWLFNTVGKGKVPICNYSGGTEISGGIFGNVLIKSIAP
                     ISFNASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFEN
                     KWVHGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14084..14140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW43_RS13120_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="EXW43_RS13120"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14831..14893
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW43_RS13120_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="EXW43_RS13120"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15682..15879)
                     /locus_tag="EXW43_RS13125"
                     /old_locus_tag="EXW43_13465"
     CDS             complement(15682..15879)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002017016.1"
                     /locus_tag="EXW43_RS13125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13465"
                     /product="hypothetical protein"
                     /protein_id="WP_002017016.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDPVSLDALNTPSKAQEQLQETSQEAHNSNKKDST
                     QALHGEDLPISDVYRTTNKQ"
     gene            16197..16412
                     /locus_tag="EXW43_RS30765"
     CDS             16197..16412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237376.1"
                     /locus_tag="EXW43_RS30765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002085442.1"
                     /transl_table=11
                     /translation="MVIVTLAIVPGESRSEAVTVTVPGPLAARNTAVKLPEALVMTARG
                     TMKAREGLLNEKLTTTPGVGLPFTNT"
     misc_feature    16432..16449
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            16458..16697
                     /locus_tag="EXW43_RS30770"
     CDS             16458..16697
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="EXW43_RS30770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_235713458.1"
                     /transl_table=11
                     /translation="MVSLEVKVIEAGPAGRLNPVGPVEPVGPVGPVGPVGPVEPVDPVD
                     PVEPVDPVGPVGPVGPVEPVEPVAPVEPVGPVGN"
     gene            complement(<16715..16771)
                     /locus_tag="EXW43_RS31395"
                     /pseudo=""
     CDS             complement(<16715..16771)
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="EXW43_RS31395"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLYFAALNPGSIGPTL"
     gene            complement(16970..17338)
                     /locus_tag="EXW43_RS13135"
                     /old_locus_tag="EXW43_13475"
     CDS             complement(16970..17338)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="EXW43_RS13135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13475"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_033729436.1"
                     /transl_table=11
                     /translation="MGNIPKISSQQSNPKIPSQQVNANTKQSNNKKARRRIITTLAFIL
                     PIIFVLQYSLNNQQEMIKEKQITVNTEQQKLSSLKKDGHSLKNDVKALTGSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     gene            17668..17838
                     /locus_tag="EXW43_RS13140"
     CDS             17668..17838
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000284255.1"
                     /locus_tag="EXW43_RS13140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_003189371.1"
                     /transl_table=11
                     /translation="MYQGDHFITEGIILEVSEKANKSLYWRWCMLAPRYEKVCGNSTKR
                     LRLIRIDDDEE"
     misc_feature    17882..17895
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(17883..17896)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            18005..18385
                     /locus_tag="EXW43_RS13145"
                     /old_locus_tag="EXW43_13480"
     CDS             18005..18385
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="EXW43_RS13145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13480"
                     /product="hypothetical protein"
                     /protein_id="WP_002127497.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGSVILHNVWVFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRVLS
                     TRIALAIIGALALWMLIVIYIK"
     gene            complement(18493..18795)
                     /locus_tag="EXW43_RS13150"
                     /old_locus_tag="EXW43_13485"
     CDS             complement(18493..18795)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW43_RS13150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW43_13485"
                     /product="hypothetical protein"
                     /protein_id="WP_170935234.1"
                     /transl_table=11
                     /translation="MKGGIKECPGKMIAGVLRKSIVVMTGGNLKKRIIVMMIGVLRKSI
                     VMMIGGNLKKRIIVIMIGVLNEISVVVNVSLFVVIVKEKVGNIFNIDLKERTCLL"
     gene            19257..19613
                     /locus_tag="EXW43_RS13155"
                     /old_locus_tag="EXW43_13490"
     CDS             19257..19613
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002032241.1"
                     /locus_tag="EXW43_RS13155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13490"
                     /product="hypothetical protein"
                     /protein_id="WP_002032241.1"
                     /transl_table=11
                     /translation="MGSRFNNCRKKCTCKHDDCWDIFEECKKEKNEKCDSSCVQGIRDE
                     LKKLINKTVRINTEGRTYIGTVSSVTCDVVKLAAIPGSVAAIISLCKIEAILPPATTVT
                     DEFDFNGVDVANKD"
     gene            19738..20250
                     /locus_tag="EXW43_RS13160"
                     /old_locus_tag="EXW43_13495"
     CDS             19738..20250
                     /EC_number="2.3.-.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127499.1"
                     /locus_tag="EXW43_RS13160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13495"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_002127499.1"
                     /transl_table=11
                     /translation="MIKLKQFTRSDFKQLINWINSEEFLIQWSGNAFTYPLNEQQLEKY
                     TECANTLAFKIMDEETKAVIGHISLGQIDNINKSARIGKVLVGNTKMRGRSIGKHMMKA
                     VLCIAFDELKLHRVTLGVYDFNKSAISCYEKIGFVKEGLLRESKRVGETYWNLWEMSML
                     EYEWNNK"
     gene            20300..20860
                     /locus_tag="EXW43_RS13165"
                     /old_locus_tag="EXW43_13500"
     CDS             20300..20860
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127500.1"
                     /locus_tag="EXW43_RS13165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13500"
                     /product="hypothetical protein"
                     /protein_id="WP_215576232.1"
                     /transl_table=11
                     /translation="MNKKTKMISIAAVSGGGKTTITESLAHELKKSKALYFDRYKFDNC
                     PVDICKWIDDGANYDEWVLTPLMNDIQRSIQDSSLDYIIVDYPFAYLNREVGKFIDVTI
                     FIDTPLDIAMARRILRDFKEDTMSEIHNNLKHYMTHARKAYLEAIHTVKPNSDIVLDGS
                     LSISEIIDQIIEELNRREVIVNG"
     gene            <20881..21113
                     /locus_tag="EXW43_RS13170"
                     /old_locus_tag="EXW43_13505"
                     /pseudo=""
     CDS             <20881..21113
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="EXW43_RS13170"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="EXW43_13505"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="KSLSDLYRRELDNFLRYGLATSNQKY"
     gene            complement(21172..22188)
                     /locus_tag="EXW43_RS13175"
                     /old_locus_tag="EXW43_13510"
     CDS             complement(21172..22188)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="EXW43_RS13175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13510"
                     /product="D-alanyl-D-alanine carboxypeptidase family
                     protein"
                     /protein_id="WP_002185782.1"
                     /transl_table=11
                     /translation="MQFLKKITVLLLSFLITALIVLYFYLYVNGPIIQAKSAILIDTNS
                     GEIVYKKNEETPIQSATLSKLMTEYIALEQLNEGKIQLDELVKISNEVFRAETSPIQVT
                     SKDKTTVRDLLHALFLTGNNRSALALAEHIAGNEDNFTLLMNDKAKQLKLSQPSPFLNA
                     TGINNDTNKQSTTTSIDVAKLATQLVKDFPDVLNVTKLTSYQFTFKDSKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNGNYSFVSTATRGDTRLISVILDAGDENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWTILFQFKNLIIQMIMIFFIITILMFLYIRQKKAEDFN"
     gene            complement(22370..23527)
                     /locus_tag="EXW43_RS13180"
                     /old_locus_tag="EXW43_13515"
     CDS             complement(22370..23527)
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016127015.1"
                     /locus_tag="EXW43_RS13180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13515"
                     /product="cell wall metabolism sensor histidine kinase
                     WalK"
                     /protein_id="WP_002085430.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWLLLAITLTPITELIIFRLVTSVIES
                     SLTLSELGKEFIRIFGHEKYIGLKESLWMMIVSYLFLFSIFSSYLYIFYRHERKVYYET
                     CIKKMIEEIRYIASGNFNHKVSIVHHNYLEELATGVNQIIEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRYYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSAPIDIVELLGQLTVQFRIQLQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAITYGNDGDHIDITAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKLLPYKA"
     gene            complement(23517..24212)
                     /locus_tag="EXW43_RS13185"
                     /old_locus_tag="EXW43_13520"
     CDS             complement(23517..24212)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="EXW43_RS13185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13520"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002016575.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKDIVELLAVYLRNEGYNIYKAYDGDEALQMICTY
                     EVDLMLLDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSQKNEDGIIRIRSVEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETVMNGEKLIHTV
                     WGVGYKIEK"
     gene            24410..25018
                     /gene="yqeK"
                     /locus_tag="EXW43_RS13190"
                     /old_locus_tag="EXW43_13525"
     CDS             24410..25018
                     /EC_number="3.6.1.41"
                     /codon_start=1
                     /gene="yqeK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000966604.1"
                     /locus_tag="EXW43_RS13190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW43_13525"
                     /product="bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
                     YqeK"
                     /protein_id="WP_002168331.1"
                     /transl_table=11
                     /translation="MLYNDIYSFTPTGKIENDIKAFLLKYNKEFTYKHSIRVANEARKI
                     AGIFYEDEEKAAIAGCLHDISAIFPNEERIAVAEEFGIEILQEEREFPMIIHQKLSSVI
                     AKEIFKIEDEEVLNAISCHTTLHKHATKMDLVLFIADKLEWDQIGTPSYLIEVKKGLEK
                     SLEHAAFVYISYLWERKYTLKVIHPWLEEAYWYLKEIVE"
ORIGIN
        1 cggatcccaa aaataggaag aattaaggtc tttgtattta ttaagtattt cctcgaatga
       61 tagtgagcca ctttcaggag tagtttcttc ttttaagcgc attaaaattg tttctgtagg
      121 atgatctttt aaaaattgaa ttgcctcttt taatacatct tcaaacattg ctttttgatt
      181 tacaatccca tggtacattg caaaagaatc ttttacacgt ttaacacgca tatctacata
      241 tcgaattccg gaatttaatt gttgtggtag actcatagtt tgatttcttg tcaaattttc
      301 atcaagaaaa cttgctccat gtaaagccat tgtaccgtga gtccctggaa tagatatttc
      361 actcaatttt gttgaatctg ctactttcga catccatgct gggttttgat agcctatatt
      421 ggattcatag gaataacctg gatgactatc agcaaaaata gtagatggtg tacttaaact
      481 tgctagtgtg aaacaagtaa ggatactaat tttaaaaaaa ttcctcattt ttattttgtt
      541 cattttatct ctcctgactt ttaaacaata gatataataa aacaagatga ttttttacta
      601 catctattgt tttcattctt aaagtaatga atttttgtgt ttgaaaaaat caaaataggg
      661 taggaagtta tttgagattt taatagtttg ttgtaataaa ttgtatctaa tagtcaaacg
      721 gattcttaaa gaattgaagc atagatgggt aaaaaacaaa ctttccgctg tactgtatac
      781 aaacaaaaca gaagtcttaa aaaagacttc tattttgtga catataatga atgataaggt
      841 ggttaacaaa tcaagataat gtgactgagt ggtaaaaatc tatttatagc tgtttcagaa
      901 tttcttataa caaggctact taggaaaagt ggatctctac aatgctaata aaaatttaaa
      961 aattctattc attaaaactt aaactaacta cagttgcgat agattgggct gcatgttccc
     1021 agcttccatc tataactttc ccaatttgtt gaccaagtgc atttaaatca tttggattta
     1081 ctgggatccc attatacgca gcaagaattg ataaaagtgg agcagtaaat ggtgtccaac
     1141 cacctctatc aatattaaat acaggcttat ctattacctt tccatcttgc actgtaaact
     1201 cataataaaa ttgatcatct ggacgaaaac ttaaatgatg agaaatttgt cccttaacat
     1261 atgttttacc gccacctaaa tttactactt caattggttt tacattaaat tcatgctcaa
     1321 atactttaat ttttttaact tctggaccat ttaaggcagc tttaactgct gtttccaaat
     1381 tattttgtgc aaatggttga atactcatct gtatctcttc ttgttggata ggagcctctt
     1441 tttcagcagc aaacaccgat gtacttggta gtgcacctgt agccaatgta gctgcaagtg
     1501 ctgtcgtcat catgattttt cttttcatct tcatagtttt cttcctccct taaagttatg
     1561 atatataatt ttttaaagac tgacatgggg caatatttta tttcataatg cacgcaaaaa
     1621 aatagtttaa gaattatgtg aaattatgtc agaaaattaa agttaattat atatgcactt
     1681 acaatgatag ctatctacac atgttttttc aattttctaa taaataatac agtaatacct
     1741 tttcataagg caatttagtg tttcaattct ctctttgtac gttttaaaca aattaaaatc
     1801 gtagtggtaa taatatattt gtaatcaaat gtcgtatata cttcgagaaa agtacacaat
     1861 atttttataa aaaactatag gaattatcat gatatagtta tcaaacgaag taagataaat
     1921 gttaatatta tgaagagatt ccagtgatct gctataaagt tactgagaaa tgagcatgac
     1981 atcatacacg catgcgattg aaaaatgtta taagtggcgt ataaaactat aacaaatact
     2041 acaaatcaat taaaaaattt cagttattct gaatgcgaag ggcacgtaat atttattgtg
     2101 aactgtagta ctgattaaga ttttaggagg aagtatgaac aagaagatta aaagaatcat
     2161 attaattatt ggtatattag taggcattag tatcttttta tatttacaaa acaatttaat
     2221 aagtataact gaggttaaaa taacctctag taaaattccc tcttctttta aaggatataa
     2281 aatactacaa atttcagatt tacataataa aaaatttggt gataatcaag acgttttaat
     2341 tcaaaaagta aaaagcataa atccagatat tattgctatt acgggtgatt taatagacag
     2401 taaatcgtac gatgcagaaa tgagtatgca agtaatacga gaacttgtga aggaatatcc
     2461 ggtatatttt gtgacaggaa atcatgaaaa atggtcaggg aaatataaca gtttagaaaa
     2521 aaaattaaag aaacagcatg tcactgtttt aagaaatgaa catgtaataa tacaaaaggg
     2581 aggacacgaa ataaacttgt taggaattga tgatccggaa tttaatactg gagatattga
     2641 tgaaggaagt attgtaaaag atgcaattgt aaaagcaaaa attgaaacgc tgccagatag
     2701 gtataatgta ttattatccc ataggcctga atttttagaa gcatatgctg atgagcaagt
     2761 agatttagtg ttatcgggtc atgcacatgg ggggcaagtt cggttacctt ttatcggggg
     2821 attagttgct cctaatcaag gaatactgcc caaatataca gcgggtttat atgaacaaca
     2881 aaatacgtct atgatagtta gtagaggatt aggcaatagt atcattccgc aaagagtttt
     2941 taatagacct gagattgtag tcgtgcagtt aaattaatct gtacggcttt tttgttcagg
     3001 agaataattt aaaggtagtt tttcttgagt acaagtttcc attacaattt tgttaaaatt
     3061 tttcaacgtt acataaagta acaaaatttg acctattgag tttgttatag tgtaaataat
     3121 caaaaaactt aaaaattagt cgagttaaaa tagttattat taagcaatat taaaaatata
     3181 aaggggtgta caaatgcata aagaatttga aattgaagaa tatacggcga ttgaggagca
     3241 aattcattat tatagtacgt ctttattagt aagtcatcct gagcaaattg taaagtattt
     3301 agaaaaacgg ttggaaaagt atgcagaaac gttacaatat gcacatttat atccggaaac
     3361 ggttatatta ccaatacagc aaatagttat cgaatattca ttagatgttg ctagaattag
     3421 aaggtattta aatttaaaaa cataacaaaa atcaaataat ttacaatgaa acagagtcga
     3481 ctttaagaaa agatattcta atgtcgactc tgtttcattg atttagtaaa taacagaaaa
     3541 aatatatgtt tgaaaagttt gacatataat aattcgagag taaaataaaa gtgagtactc
     3601 actcatttta aagaaaaggg ggatttttag tgcagcaacc ttcaattatt ttacgagatg
     3661 tatcaaaaaa atttaggaaa aaagaagttt tgcataacct ttcgctgcaa gtagaaaaag
     3721 cagaaatttt tggcttggtt ggaccttccg gatcagggaa aacaacactc attaaaatga
     3781 ttgcaggtat taatgagtca actacagggg atgtaattgt ttttaataca aacatgccta
     3841 atctaaatga aatgaaaaga attggttata tggctcaggc tgatgcatta tacgaagaac
     3901 tatcggcata tgaaaatgca gattttattg caacgatgta tgggttaaaa ggtaagcgta
     3961 agaaagagag aatcgtagaa gtttttgaat ttttgcaatt atcagatcat gcgaaaaagc
     4021 aagtacagca tttttcaggt ggaatgaaaa aacgtttatc attggcgata gcactccttc
     4081 atgaaccaga aatattaatt ttagatgagc caacagttgg gatagatcct ctacttcgaa
     4141 aatcgatttg ggagaagttt tatgacctta aaaagaaagg aacaactatt attgtaacaa
     4201 cgcacattat ggatgaagct gagttttgcg aacgtctagg gctaattaga gaagggaatt
     4261 tagttgcgat tggcacaccg gaggaattga aaaaacaaac atcttctgga cgaattgaag
     4321 atgtctttat gttagaagga gtgattgaat catgagagtt aatggtgtag tcatccgtat
     4381 cattcgtcaa ttttttcgag ataagcgttc tttagcaatg atgtttgggg caccaatgtt
     4441 attactttgg ttattatcgc taatatttac acaaaaagac tatataccgc atattgctgt
     4501 agtcgatgta cctgctccta tagtaaaagc aatgaaaaat caagaagcat caatttatga
     4561 atatagtaaa gacaaagcaa tttcggaatt agaaaagcaa aaggtagatg cagtaattca
     4621 tttagaaaat ggaaaaatga atcttctatt agaaggcagt gattcatcaa aaaaccgtgc
     4681 agtacttcaa gtattgcaaa agagtacaga gaagaataat gtatcaatga tgaagcctga
     4741 agtggattat ttacatggct ctaaagacat tacgatgttc gatgggcttg gtcccgtatt
     4801 aattggtttc tttacatttt tctttgtatt tatattgtcc ggagtatctt ttgtaagaga
     4861 acgtttaagt ggtacattag agaggttatt gtccacacca gtgagaagat gggaaatagt
     4921 tttaggatat attattggtt ttggaatctt tgcacttata caatctatta taattgtaag
     4981 tttttcagtt tatattttag atttatatgt agctggctca atatggctaa cgctacttat
     5041 aacatgtatg ctttctttaa ctgcactaac attaggcaca tttttatcgg catacgcaaa
     5101 taatgaattt caaatgattc aatttatacc gcttgttatc gtgccacaag tcttcttttc
     5161 tgggttgttt ccaatggaat ccatgaatac atggttacaa atgttaggta aattatttcc
     5221 actcacatat ggtgctgacg ctatgagaca agtaatgatt cggaatcaag ggtttacaga
     5281 gattgcatta gatcttactg tattactact tttttcacta ttatttgcag taggaaatgt
     5341 atttgcatta aagaaacatc gcaaaatata atgatgataa aaaggagcac aataaatgaa
     5401 gaaggattgg ctggaagaat tagttgccgc aacgaatgct gataaacgta atgaacgtca
     5461 aatgcgtata ttagaggcag ctgttgatat gtttggagaa aaagggtacg cctcaacttc
     5521 aacgagtgaa attgcaaagc gagctggtgt agcggaagga acaatcttcc gctactataa
     5581 aacgaaaaaa gatttattgt ttgcagtcgt gatgccgacc ttaacaaagt ttgctgcacc
     5641 atttttcgta caagcctttg caaaagaaat atttaaaaca gagtatgaat cgtatgaagt
     5701 gcttttaaga gtaataattc aaaatagatt tgaatttgct aaaaagcact ttccaatgat
     5761 aaaaatatta attcaagaag taccatttca gccggaacta aaaagtgaaa tacaacaatt
     5821 aatagaaaca gaactgcttg tacattttaa aaagctgatt gcaaagtttc aagaagaagg
     5881 ggaaattatt gaacttccac catcttccgt attacgtctt actttatcag ctgtattagg
     5941 gttgctctta acgaggtttt tattattgcc ggaagagaaa tgggacgatg aagtggaaat
     6001 tgaaaatacg attcaattta tattgtatgg actaacgcca cggaggtaat gtgatgcgac
     6061 aatttgctaa accgataatt gttgtaagta aatgtttaga atttgatgcc tgtcgttata
     6121 atggagagat ggttccagat ttaacaattc gaaacttgca gccatttgtt acatttatac
     6181 ctgtatgtcc tgaagtagaa attggtttag ggactcctcg tgaaacgata cgtattgtag
     6241 aaaaaaatgg tgcgaatagg cttgtacaac cgtcaatacg agaagatgta actgaaaaaa
     6301 tgaatgaatt ttcaaatgca tttttacaaa cattacctga agttgacggt tttattttga
     6361 agaatcgttc gccaagttgc ggaactcgtg atgtgaaaat ctattctggt tttgaaaaag
     6421 ggccagtaaa aggaaaagga actggattat ttggtggagc agtaataaaa aaattttcgc
     6481 atcttccaat tgaagaagaa ggtagattgt cgaattttat tattagagag catttcttta
     6541 caagattgtt tacaatcgcg cattacaaaa tgattaaaca tactaaaaac ataaaagaac
     6601 tcgtagcgtt tcaatcagat tataagtatt tatttatggc atataatcag gtgaaacaaa
     6661 aagaattagg gcgtattatt gcaaatcaaa aaaatgaaac aattgaagtc gtatttgata
     6721 actatgagaa gactttatat gaattattta ttcgcgcgcc tcgctataca tcgaatgtaa
     6781 atgtatgtga gcacattttc ggatatttta aaacaaagct aaaaaaacaa gaaaaagatc
     6841 attttttaga gctgttacag aagtattctg aaaagaaaat cccacttagt agtttacttg
     6901 tcattttaaa aacatgggcc attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata ccctgaaggg ttagtagaaa tttctgattc gggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattggtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attgtctaac taatattcgt gtcttttaag aagtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg attttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcggaatttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggtatccca ttcccggaag agtatggagg ttcaggtggc gatacgttat
     7441 cgtacgcgtt agctgttgaa gagattggtc gtgcttgtgg tggaacaggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 agaaattttt agttccaatg gcgtcaggta aaacgttagg tgctttcgga ttaacggagc
     7621 caaatgctgg atctgatgca gggggcacac aaacgaaagc aattttagat ggcgatgaat
     7681 atgttattag tggtgaaaag tgctggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctat caacggtttt gaagacaatg gtaaaaaacg tatttctgca tttatcgtac
     7801 cgactactag tgaaggatta acgatttcaa gcccttacga taagatgggt gttcgtgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tacgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaattg
     7981 cagcattagc agtaggtatt gcacaatctg catttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaaa ccgatttcta atttccaagc gattcaattt aaattggctg
     8101 atatggcgac tgaagtagaa ttagcgcgta atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggt aaagaagcgg ctatggcaaa gttgtttgca tctgaagctg
     8221 caagtcgtat agcaaatcat gcagtacaaa ttcatggtgg atatggctat atgcgtgaat
     8281 atgaagttga acgatatatt cgtgatgcaa aacttttaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gcaagacatt taggatgtag ataaaaagga ggagtcacta
     8401 tgtttcaaaa aatattaatt gctaatcgcg gggaaatcgc agttcgcatt atgaaaactt
     8461 gtcaaaaact tggcattcgt accgttgcta tttattctga ggctgatgaa aatgcccttc
     8521 atgtaaaatt ggcaaatgaa gcttacttag taggcggtcc acgtgtccaa gaaagctatt
     8581 taaaccttga aaaaattatg gaaatagcta agaagacaaa tgctgaagca atccatccgg
     8641 ggtacggatt attatcagag aatccatctt ttccgattcg ctgtaaagaa gaaggcatcg
     8701 tatttatcgg tccttcagaa gaaatcatta ctaagatggg aagtaaaatt gagtcacgta
     8761 tagcgatgca agcagcagat gtaccagtag ttccaggcat tactacaaat atagaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 cgggcggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagtaa taaaacaaga gcgcaaaatt tctttggtaa cggagaaatg tacttagaac
     9001 gctatatagc agatgcacat catattgaaa ttcagctttt agcagataca catggtaata
     9061 cagtgtattt atgggaacgc gaatgttcag tgcagcgccg aaatcaaaaa gtaattgaag
     9121 aagcaccttc accattttta gatgaggata cacgaaaggc tatgggagaa gttgctgtac
     9181 aagctgctaa agcacttggt tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 aaaagaactt ttatttctta gaaatgaata cgagattaca agtagaacat ccagttacag
     9301 aagaaattac tgggttagac ttagttgaac aacaattact tatcgcatat ggtgagaagc
     9361 tatcatttac acaggatgat gtaaaacgta gtggtcatgc cattgaggct cgtatttatg
     9421 cagaagatcc gaaaacattc ttcccatcac ctgggaaaat tacagattta acgttaccga
     9481 caaatatacg tattgatcac tttttggaga atcaagtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtaatc gcacatggtg aaactcgtga agaagcgatt tcaaaattaa
     9601 aaattgctct agaagagtta aaagtagaag gtattaaaac aaacacacca atgttactgc
     9661 aagtactcgg agacgatgtg ttcaaaagtg gtatttatac aacgggtttt gtaacgaaac
     9721 aacttgttaa aaagtaagat ttatgaatat taagggggaa aaaatgatga cgaaagtata
     9781 tgcatcgatg gcaggaaatg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatcg tttcagaaga
     9901 agccggaact gttatgaaaa ttaacgtaca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacagaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagcg ggattgtcgt acgttgaagt
    10141 ttcctcattc gttcacccta aatgggttcc tgcattagca gatgcaagtg atgtgttttc
    10201 tgagctaaaa agggatccaa atgttacata tgcagcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcacaataaa agtaatatta ataaatctat taaagaagca ttagctgtaa ttgaagatat
    10381 aacaaaacag gcaacgttcg aaggtaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgccac agcagttgac gaaatatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctctcgg tgacacgatt ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggaa tggctctggc gaatgtagtt aagtctttag aatatggtat
    10681 tacaacgttt gatagttctt gtggtggact cggaggatgt ccttatgcac caggagcatc
    10741 gggtaatgtt gctactgatg acttagtgca tatgctccat aagctgggag tccaaactaa
    10801 tattgatgaa gaaaagttat tgagagctag tcagtttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tgcaattaca aaacatttca gttgactatg ttacaccgca cgttgtaaag atttcgttaa
    10981 atcgtgaaag acaagcaaac tcattatctt tggcattatt agaagaatta caaactatat
    11041 taactcaaat aaacgaagaa tcaaatacgc gcgttgttat tttaacaggg gatggcgaaa
    11101 aagcattttg cgctggtgct gatctaaaag agcgtgccaa catgagtgaa gaacaagttc
    11161 gccatgctgt gggtatgatt cgttctacta tggagatggt ggaacaatta ccacaaccag
    11221 ttattgctgc tattaatgga atcgcacttg gcggaggtac tgaattaagc ttagcttgtg
    11281 attttagaat tgcttctgac actgcaagtc taggtcttac tgaaacttct cttgcaatta
    11341 tacctggagc aggtggtact cagcgtttac cgagattaat tggagtcggt agagcgaaag
    11401 aattaattta tacaggaaga cgtatttcgg cgcaagaagc gaaagaatat ggtttagtag
    11461 aattcgtagt accagctgat ttactagaag agaaagcaat tgaaattgca gatcgaattg
    11521 ctaaaaatgg tccaattgct gttcgattag caaaagaagc aatttcaaat ggaattcaag
    11581 tagatttaca taccggctta caaatggaaa aacaggcgta tgagggcgta atccatacga
    11641 aagatagatt agaaggatta caggcattca aggaaaaacg caaaccaatg tataaggggg
    11701 agtaaatatg ttagatcaaa aacaacaatc taattcattt gaagaacgag ttgaaacaat
    11761 taagcaaggc ggggcaccga aatatcatga acaaaacaaa gcaaaaggga aactttttgt
    11821 tcgagatcgt ttagctcttt tattcgataa tggtgaatat gtggaagatg cattatttgc
    11881 aaattgtgaa caaactggat taccagctga tggtgttgta actgcgactg gtaaaataca
    11941 tggtcgtact gcgtgcgtaa tggcaaatga ttcgactgta aaagctggat catggggagc
    12001 acgtacagtt gaaaaaattc tacgaattca agaaacagca gaaaaattac gtgtaccgtt
    12061 attttattta gttgattctg ctggagcgcg tattacagat caagttgaaa tgttccctgg
    12121 acgccgcggt gcgggaagaa ttttttataa ccaagtgaaa ttatctggaa aagtgccaca
    12181 aatttgttta ttatttggac cttcagcagc tggtggtgcg tatattccag cattttgtga
    12241 cgttgttatg atggttgaag gaaatgcttc tatgtattta gggtctccgc gtatggctga
    12301 aatggttatc ggtgagaagg taactttaga agaaatgggc ggagcacgta tgcattgctc
    12361 agtatcagga tgcggagatg ttttatgtaa aacagaagaa gatgcaatta cgcaagcaag
    12421 acaatatatt tcttattttc caagtaacta tttagaaaag actcctttga ttacacctca
    12481 agaaccgaaa cagttcgata aaacgttaga agaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaacagaat tattgatgaa ggttctttct ttgaagtgaa
    12601 aaaattattt gctcaagaac taattacagg tttagcacgc attgatggta agccaattgg
    12661 cattattgca aatcagccgc gtatgaaggg cggcgtatta ttccacgatt cagctgataa
    12721 agcagcgaag tttataaatt tatgcgatgc ataccatatt ccattattat tccttgcaga
    12781 tgtacctgga tttatgattg gtacaaaagt agaacgtgcc ggaattattc gtcacggtgc
    12841 aaaaatgatc tctgcaatga gtgaagcaac tgtaccgaaa atttctatcg tcgttcgaaa
    12901 agcatatgga gctggcttat atgcaatggc aggtccagcg tttgaaccag attgctgctt
    12961 agcattacca acagcttcta ttgcagtaat gggtccagaa gcagcggtca atgctgtata
    13021 tgcaaataag atagcagctt taccagaaga agagcgtgca agctttattg ctgaaaaacg
    13081 agaagagtat aagaaagata ttgatattta ccgtttagca tctgagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gctaaaagga cgattcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa atcaaggagg ggaaaacatg aaacaagcag tttggtttcc
    13321 aacagaagaa tataaagaaa aaacgcgttt atttggttgg atgaaatcat taggctatga
    13381 agattacgaa gctttttata ataagtcaat tgaagaaaca gcttggtttt ggggagaagc
    13441 tgagagagca gttggctatc agtggatgaa accatataca gaagtgttag atttagaaaa
    13501 tggtacaccg tttgcacagt ggtatactga gggaacttgt aacgttgtag aatctgcttt
    13561 atctcgctgg cttgcagacg ataaaacgaa aacacaagca gcacttatgt atgaagggga
    13621 aaacggaact tcgaaatcat ttacatatga agagcttgac agctgggtaa gccgtgttgc
    13681 caacggtttg aaacatgctg gtattgaaaa aggtgatcgt gtaacaattt acatgccaat
    13741 gattcctgaa acagttgttg ctatgttagc ggtaatgaaa attggagcga ttatttcacc
    13801 aatattctca ggttttgctg ctgatgcagt aatgacacgt gtacaagcag ctggttcaaa
    13861 aatggttatt accgcagatg gcttttcacg ccgtgggaaa attgtttcat taaaagatga
    13921 agtagataaa gcttgtgaac attgtccaac tgttgaaaag gtggtaattg ttcgtcatgc
    13981 aggaaatgat tttacaccgc ataattatga tttttcatgg agtacgttag aaaaagaaaa
    14041 accatttata catgctgaag aaatgaacag tgatgatcca ttaatgctta tatatacatc
    14101 tggaacgact ggtaagccga aggggacagt acacacacat gctggtttcc cgctaaaatc
    14161 tgcatttgat gcaggatttg gaatgaatat aaaacaaggc gaccgagtat tatgggtaac
    14221 tgatatgggc tggatgatgg gaccattttt actattcggc tctttaatta atggcgcaac
    14281 aatggttatg tatgaaggtg tcccagactt tccagaagca gaccgcttat gggagacagt
    14341 cgataaatat gaaattactc atctcggtat ttcaccaacg ttaatccgtg cattaatggc
    14401 aaaaggtgat gaatatgtaa ataaacactc gttaaagagt ttagaagtat tcgcatcaac
    14461 aggagaacct tggaatccag acccatggat gtggttattt aatacagttg gtaaaggtaa
    14521 agtaccaatt tgtaactatt caggtggaac tgaaatttca ggtgggattt tcgggaatgt
    14581 cctaattaag tcgatcgcac cgattagttt taacgcatct ttaccaggaa tggcagcggt
    14641 tgtacttgat gatcaaggta aaccaattcg agatgaagtc ggagaactat gtttagaaaa
    14701 accttgggta ggtatgacga aaagtttctg ggaagatgat gaacgttatg taaacacata
    14761 ttggtcacgc tttgaaaata aatgggtcca tggggactgg gttatttatg acggtgagca
    14821 atacatcatc acaggacgtt cagacgatac gctaaatatt gcagggaaac gtattggtcc
    14881 tgctgaatat gaatctattc ttgtgaaaca taatgatgta atagaagcag cggcagttgg
    14941 tgtaccggat gatgtaaaag gagaagtttg tcattgtttt gttgtattac gagatggtgt
    15001 aacattctca ggagaattaa agaaagaatt aatgagttta gtaaactctc atattggtaa
    15061 agctttatgt ccaaaagaca tccacgttgt agaagattta ccaaaaacac gaaattctaa
    15121 agtaatgcga cgtgtcataa aagctgctta cttaggaaaa gaattaggag atttatcgtc
    15181 acttgtaaat cctgaagtgg taccctttat tcaaggacta cagtctagca aactataaaa
    15241 ttacgaatga gctctatgta aatagagctc atttttaatg tttacaaaaa gaaaagagag
    15301 gaaaagtaaa tttgaagtta aaaaatctac tattagtgtt aagtatgtct gtttgttttt
    15361 agtttttatc aaaataggat actgtggctg tctattcaat ggagtgaatg aattttgtta
    15421 agaatgaaaa tttagtgaag aaaaaagtaa tgaataaaag gagaaatccc tgggggacag
    15481 ggattcaata agggagatat tattgtcgtt caatgtcgaa atttggcgta tccgacaaat
    15541 taatattatc acgaattttc aggagattgt gatagtggat gtgtcaaaaa tgtgtacggg
    15601 tttcatataa aagtgttatt taaataggaa aagggaaaag aattaagttc actcgttctt
    15661 aagatttttt cccttttaaa tttactgttt gttcgttgtt ctatatacat ctgaaattgg
    15721 taaatcttcg ccatgtaaag cttgagtact gtcctttttg tttgaattat gtgcctcctg
    15781 agaggtttct tgcagttgtt cttgggcctt actaggggta ttcagcgcat ctaatgacac
    15841 aggatcaagt tgttgactta ataaatcttt tttatccatg ttatgtagct cctttttgaa
    15901 cttagatata aaaacaaagt atttttaaat agttacgtgg gtattatgta tctttgaatg
    15961 gaattatata cacaaactat attgagaatt taactaatta taaaaattac ttgtgctgac
    16021 aagcttaaga aatataaaga tcattagttc ttaataaaag cgttatttta gtaggctgtt
    16081 acgaaatttc atttgaaagg aacatcccaa tgataaaaaa gagcactgta aatcagtgct
    16141 catcttatta gatattgctt agtccttaaa aataaaacca ttacggacaa ttcacaatgg
    16201 taatagtgac gctagccatt gttccaggag aatcaagaag tgaagcagta acggttactg
    16261 ttccaggccc attagcggct agaaatacag cggtaaagtt acctgaagca ttggtaatga
    16321 ccgcaagagg aaccatgaaa gcaagagaag ggttactgaa tgaaaaactg accactactc
    16381 ctggagtagg actaccgttt actaatactt gacccgaaaa aaataaagta ttatttcctt
    16441 gagtggatac acatgctgtg gtttcgttag aagtcaaggt aatagaggca ggcccagcag
    16501 gaagattaaa tccagttggt ccggtagagc cagttggtcc agttggtcca gttggtccag
    16561 ttggtccggt agaaccagtt gatccggttg atccggtaga accagttgat ccggttggtc
    16621 cagttggtcc agttggtccg gtagaaccag ttgagccagt agctcctgta gaaccggtgg
    16681 gaccagtagg gaattgaaag ggttgaacag gtggaagtgt aggtccaata gaacccggat
    16741 taagtgcagc aaaatataaa aactcgtcca ttatttatca cctctaaaaa tcgtattact
    16801 aatagtaaat gtaatgatag agcaatgtga aatggacaag cggttgtatt ttaataaatt
    16861 aaacaaaata gttatttgat agaaaaagaa attagtatgt ttattttaga aattaaatat
    16921 aaaaaggcga ttatcgtcaa atcgcctttt ggggtaatgc agtgtaattt tattcagtta
    16981 tttgaaatat agtttcattc ggtttggaaa atccatacag tttccttgcg aattttaaaa
    17041 tttcttcttc actacctgtt aaagccttaa catcattttt aagggaatga ccatccttct
    17101 ttaaagaaga taatttttgt tgctccgtat taaccgtgat ttgtttttct ttaatcattt
    17161 cttgctggtt attaagagaa tattgaagga caaaaattat aggtaatata aaagctaaag
    17221 tagttataat acggcgtctt gcttttttat tattactttg tttggtgtta gcgttcactt
    17281 gctgtgaggg tatcttagga tttgattgtt gtgatgatat ttttgggatg tttcccatta
    17341 aaatgcctcc attactgatt gtagaattta aactgtttaa aagtattata aatgttcaat
    17401 gggaattcta gaagatagtt taatataggt gagttttgta aagtttaaac aaaatcctta
    17461 tttaaataaa aggaaccccg attgtctgcg gggctcctaa gggtaatcgt caagtaatga
    17521 cgtactcgac tagttaacga tatcatgaat tttttggtaa atatactggt aaatgcgtcc
    17581 aaattaatga gagcattatt tgaaacaaaa acgctatttt aatagggagg ggaataatga
    17641 tgattccatg ggacaagcga gtatacattg tatcaaggtg atcattttat tacagagggg
    17701 ataattttag aggttagtga aaaggcgaat aaatcattat attggcgttg gtgcatgtta
    17761 gctccaagat atgaaaaagt gtgcggtaat agtacaaagc gacttcggtt gattcggata
    17821 gatgatgatg aagaatgata taaaaatttc attttgtaga gaaatgaggt gattaaggat
    17881 gggcatagaa tatgccatgt ttgtattaaa aaagagcaga atttagccta tatataaaga
    17941 tgttggaatt gttctaaagg ggggaatatc tggaatataa ataattgagg ggagtgaact
    18001 aataatggaa actagtactt ttttaggatt gttttgggga tggataacgg ttatcgtatc
    18061 gggaatactt ttcgtacgtc catcggtact acgtgaattg aaaaaattag tggttgaaga
    18121 cagaggattt ggtattatgt atggttttct atcgattttc ctagggttag gtagtgtaat
    18181 cctacataat gtatgggtat tcaactggca ggggttccta acggttattg catggcttgc
    18241 attattaaag ggaatctaca taattgcata tcctgaaccc tccaagaaaa cagactttga
    18301 attaagggta ctatctacac gtatagcgct cgctatcatt ggcgccttgg ctttatggat
    18361 gcttatagta atctatataa aataatcatt ttctaataag aactatatta aaataaatct
    18421 ctacgtgttc attgacaaaa agctgactat acttagtcag ctttttgtat attacattct
    18481 agtatttatc ggtcacaaaa gacatgttct ctcttttaag tcgatattga aaatgttacc
    18541 aactttttct tttacaatga caacaaataa agaaacattt acaacgacac ttatttcgtt
    18601 tagaactcca atcattatca caatgattct tttctttaga tttccaccaa tcatcattac
    18661 aatgcttttc cttagaactc caatcatcat cacaatgatt cttttcttta gatttccacc
    18721 agtcatcaca acaatgcttt ttcttagaac tccagcaatc atttttccag gacattcttt
    18781 tatacctccc ttcaatagga ttcatactat tttatgtttt agtaaaagaa tggcttgttt
    18841 attaacctat tattttacct ttatatgata gagtgctttc tactagatat agaattcata
    18901 caaactatgc taattttcaa gagatagttg agagaactac tggttatgat attaatcaac
    18961 aaacacttgt tgaaggaaac gttaagattt taaataatat cttattttgg agtacgcttt
    19021 tctgaatgta tatttcacaa tggtaaagga aaaatacacc atatcactgc gaacaaagcc
    19081 tatgtatatg tgaagtaata ggaaaaggtg gtccctattc aaggagccgg cttattaaaa
    19141 gtataaataa gaaggtttag tacaagtgtt tgtttttttg tttctatgct tttgtctcgt
    19201 acacttttaa gctattggac atactttact agtagaaagg attagggggt gaggttttgg
    19261 gttctcgatt taataattgt agaaagaaat gtacgtgtaa gcatgatgat tgttgggaca
    19321 tttttgaaga gtgtaaaaag gaaaagaatg agaaatgtga cagttcttgt gtacaaggaa
    19381 ttagagatga gcttaaaaaa ttaattaata aaacagtgcg aattaacact gaaggacgta
    19441 cttatatagg tactgtttct tcggtaactt gcgatgttgt taagctagct gctattcctg
    19501 gttcagttgc agcaattata tctctttgta aaattgaagc aattttacca cctgctacaa
    19561 ctgttactga tgagtttgat tttaacggtg ttgacgtagc aaataaagat taattatgct
    19621 ttattgatgc taagccattc ttatgaatgg ctttttattt tgtttaaaag ggaatatatt
    19681 tttcatatag aaataaattt gaaggtgtat aaaaggttgt gtgaaaggag aatgagagtg
    19741 atcaagctga aacaatttac aagatctgat ttcaaacaat taataaattg gattaattcc
    19801 gaagaatttt taatacaatg gtcgggaaat gcattcacat atcctttaaa tgaacagcaa
    19861 ttagagaaat atacagaatg tgcaaacaca ctggcattca aaataatgga tgaagagact
    19921 aaagcagtta ttggtcatat ttctcttgga caaatagata atataaataa gtctgctaga
    19981 attggaaaag tgctagttgg taatacgaaa atgagagggc gttctatagg gaaacatatg
    20041 atgaaagccg tactttgtat tgcttttgat gaattaaaac tacatagagt aactcttggt
    20101 gtttatgact ttaataagtc agctatttct tgttacgaaa aaataggttt tgtaaaagaa
    20161 ggtttattaa gagagtcaaa aagagtagga gaaacgtatt ggaatttatg ggaaatgagt
    20221 atgttagaat atgaatggaa caataaataa tagtatttta taattatatt atgttaacaa
    20281 aaggggtttg gtgggaatcg tgaataaaaa aacaaaaatg atttcaattg cagctgtttc
    20341 agggggcggt aaaactacca ttacagaaag tttagctcat gagttgaaaa aatcaaaggc
    20401 tctatatttt gatagatata aatttgataa ctgtccggtt gatatttgca aatggattga
    20461 tgatggagct aattacgatg aatgggtact tacaccgcta atgaatgata ttcagcgttc
    20521 tatacaagat agtagtttag attatattat tgtagattat ccttttgcat acttaaatag
    20581 agaagtggga aaattcattg atgtaactat atttatcgat acacctttag atattgcgat
    20641 ggctagaaga attttgagag attttaaaga agatacaatg agtgaaatac ataataattt
    20701 gaaacattac atgacacatg cgagaaaagc ttatttagag gcaattcata ctgttaagcc
    20761 gaattcggat attgtattgg atggatcttt atctataagt gaaataattg atcaaataat
    20821 agaggaactt aatcgaagag aagtgattgt gaatggttaa atgtataaaa cgatatgtac
    20881 aagtcattat ctgatttata tagacgagaa ttagataact ttttgcgtta tggtctggcg
    20941 acttcgaatc aaaaatattg aaagcttcat ggacagataa aacatataaa tacggtgaag
    21001 ttttaatgca tgtaattgta catgaaattc atcatattgg tcagatatct atatgggcaa
    21061 gagaattaaa tcttcagccc gtttcagcga atttagttgg aagaggattg tagatttaga
    21121 aaccgacttg cagtgtaaac gcaagtcggt ttttatatat aagaagattt cttaattaaa
    21181 atcctcggct tttttttgac gtatatataa aaacattaag attgtaatga tgaaaaagat
    21241 cataatcatt tgtatgatta aatttttaaa ctgaaacaat attgtccaag atgtaacagc
    21301 atctttaaaa gcttggagtg cagagtacga ggaaggatca aaaccgtact gaagtaactt
    21361 ttttgtttca ataaaagtac tgttttcatc accggcgtct aatattactg aaataagtct
    21421 agtatctcct cgtgtggctg tactgacaaa actataatta ccattagttg aaaaactagt
    21481 ttgtaagccg tcaacacctt ggagtttaat gtttttatta agggaatata tcattttatt
    21541 tgtattgaaa acttttgaat ctttgaaggt aaattggtaa gaggttagtt tcgtaacatt
    21601 caatacatct ggaaagtctt ttactaattg tgttgctagt ttagcgacgt ctatcgatgt
    21661 tgtagttgat tgtttattcg tatcgttatt aattccagta gcatttagaa acggggatgg
    21721 ttgtgataac tttagttgtt ttgctttgtc attcattaaa agtgtaaagt tatcttcgtt
    21781 tccagcaatg tgttctgcaa gggcaagtgc ggaacgatta ttccctgtca aaaacaatgc
    21841 atgaagtaaa tcacgaaccg tcgttttatc tttcgaagtt acttgtatag gactcgtttc
    21901 tgctcggaaa acttcgttac ttatttttac taattcatct aactgtattt ttccttcatt
    21961 cagttgttcc agtgcgatat actctgtcat taatttagat aaagtagctg attgtatagg
    22021 agtttcttca ttttttttat aaacaatctc accagaatta gtatctatta aaatagctga
    22081 tttagcttga ataattggac catttacata aagataaaaa tataaaacga taagtgcagt
    22141 aataagaaaa gataataata aaactgttat tttttttaag aattgcatta gcgatcctcc
    22201 tactattaca tcaataatat tattgtaaaa aggaatgctt aattaggaag aaagaaaagg
    22261 taaagaattt ctaaagaatt ataaaggatt attaaatttt ggatattgat ggaatataaa
    22321 aggttcaatt ttttatatga taaaaaattg aacctataaa tatgtggtat taagctttat
    22381 aagggagtaa ttttacagtg aaagttgttt ttttatcatc gctatatact tcaattgttc
    22441 ctttatgcaa ttcaacaata ctttttgcaa ttgctaatcc gagcccagat ccaccagtgt
    22501 ttgttgaacg tgatttttca acacgataaa aacgttcaaa aatatgaggt aaatcagtac
    22561 tagggatagg ttgtccgtaa tttgttatat caattgtaat catgttattg ctttcgtaag
    22621 cggtaatatc aatatgatct ccatcatttc cataagtaat agcgtttatg attagatttt
    22681 caaacacacg tactaattta tccccatcag ctagtaccat tagcttttga gatgggaaag
    22741 aagggcgaca ttcaatatta gcttcttgaa gctgtatccg aaattggaca gttaattgtc
    22801 caagcaattc tacaatatca atgggagcag aatataaact taactcttta ttttgaacgc
    22861 gtgtatattc aaacaagtca ttcattaatg cattaagacg agttacttta tcgtaaatga
    22921 cttgaatata gtatcgtaat tctacttcat ctctataatt atcatgatgg attaaattta
    22981 cgtatccaac tatagatgta agaggggttc gtaagtcatg tgatacattt gtaataagtt
    23041 cgctttttgc ttgttctgcc tgtctttctt catcaatcga aacttttaat tgctcaataa
    23101 tttgattgac cccagttgcc agttcttcta aataattatg gtgtacgatg gaaactttat
    23161 gattaaagtt tccacttgca atataccgaa tctcttcaat catttttttt atacaagttt
    23221 catagtaaac ctttctttca tgacgataaa aaatgtataa ataggatgag aaaatagaaa
    23281 ataaaaacaa ataagataca atcatcatcc ataaagactc ttttaatcca atatattttt
    23341 catggccaaa aattctaatg aattcttttc ctagttcgct tagagtaagt gaactctcaa
    23401 ttacactcgt tacgaggcga aatataatta attcggtaat tggtgtaaga gtgatagcta
    23461 ataaaagcca aaaaataagc ttccactttg gtatatcttt taatatatca aatgcttcat
    23521 ttctcaattt tatatcctac tccccaaacc gtatgaatta gtttttcacc attcattacg
    23581 gtttcaagtt tatcgcgtaa attactaata tggaccatta ccgttttatt agaaccataa
    23641 ccgtcttcat tccaaactcg ttcgaatatc tcttcagagc taaatactct tccagtatta
    23701 ctcgctagta aatataaaat atcaaattcg atagaggtga gtttaatata ttctccattt
    23761 actttaacag tatgattatg tttatgtatt tcaacagaac gaatacgaat aataccatct
    23821 tcattctttt gggaagtagc attttggaaa gaggatcttc gtaataaagc cttcactcta
    23881 gccactaatt ctagtggatt aaacggttta atcatataat catctgcgcc ggtcataagt
    23941 cctaaaattt tatccatatc ttcagccttt gcactaagca taaggatagg tacagtatta
    24001 ttttcacgca cttcttgaca aacttccaat ccgtttcgtt ttggcatcat aatatctaaa
    24061 agcataaggt caacttcata tgtacatatc atttgtaatg cttcatcacc atcataagct
    24121 ttataaatgt tatagccttc atttcgtaaa taaacagcca gtaattctac aatatcttta
    24181 tcatcatcaa taattaatat gtttttattc attttatagt tagttccttt ccttacaatt
    24241 aatcaacatt actataatat caaacattta tgtattttgt agtaatgttt ctacataaaa
    24301 tttcatgtat cgtattaaaa aggaattaaa acattcataa cgaatataaa ataagaagga
    24361 tatttaaact ccacattata ctgaaagata gttataaggg ggacttgcta tgttatataa
    24421 tgatatatat tcatttactc caactggaaa aatagaaaat gatattaaag cttttctatt
    24481 aaaatacaat aaagaattta catataaaca ttcaattcgt gtggcaaatg aggcgagaaa
    24541 aattgcggga atattttatg aagatgaaga aaaagcagcg attgcagggt gtttacatga
    24601 tattagtgca atctttccga atgaggagcg gattgcagtt gctgaagaat ttggcataga
    24661 aatattacaa gaagaacgag agtttccaat gattattcat caaaaattat cgagtgtaat
    24721 tgcaaaagag atattcaaaa tagaggatga agaagtttta aatgcaatca gttgccacac
    24781 tacgttgcat aaacatgcaa cgaagatgga tttagtatta tttattgctg ataaattaga
    24841 atgggatcaa atagggacac cgtcatattt aattgaggta aaaaaaggat tggaaaaatc
    24901 tttggaacat gctgcttttg tatatatttc atatttgtgg gaaagaaaat atacattaaa
    24961 agtcatacac ccgtggttag aagaagcata ttggtattta aaagaaattg tagagtagaa
    25021 agggtataaa aatgcaattt aaagaatata tgaatcaaac attcccagga gttacgttag
    25081 taccgtccat atactttcag tgggaaaatc atcttcattt tgattttggg aaagataaat
    25141 atcaattcaa agaagatggt aacacgtata atatggaata ttttacacaa ctatataggt
    25201 ataataaaag tctatttaaa gatatatttt caaaagaa
//
