LOCUS       NZ_CP036071            26364 bp    DNA     linear   CON 25-JUN-2024
DEFINITION  Bacillus wiedmannii strain JAS07/5 plasmid p79.
ACCESSION   NZ_CP036071
VERSION     NZ_CP036071.1
KEYWORDS    RefSeq.
SOURCE      Bacillus wiedmannii
  ORGANISM  Bacillus wiedmannii
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 79335)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 79335)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.157x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018741285.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 04:17:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,980
            CDSs (total)                      :: 5,827
            Genes (coding)                    :: 5,631
            CDSs (with protein)               :: 5,631
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 88 of 196
            Pseudo Genes (incomplete)         :: 110 of 196
            Pseudo Genes (internal stop)      :: 59 of 196
            Pseudo Genes (multiple problems)  :: 52 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 13305
            Orig. end                         :: 39669
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036071.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..26364
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..26364
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26364
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16364](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16364
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            1365..2555
                     /locus_tag="EXW41_RS26850"
                     /old_locus_tag="EXW41_27215"
     CDS             1365..2555
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017763772.1"
                     /locus_tag="EXW41_RS26850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27215"
                     /product="biotin/lipoyl-binding protein"
                     /protein_id="WP_088064991.1"
                     /transl_table=11
                     /translation="MLQNTVRTPKKKKKWIIIGVIALIIIVAAINIFVMQGEKRATVKT
                     DSVSFEKVTERKFNNTKLISGQVKPGNIESFYADPTKGKVKDIAVKEGQEVEKGTKLFS
                     YDNEEINLQVKQAELDQKMADMRYDQGKKKIDSLKKEIKKAKDSGAGKEVTDSMEEQVS
                     ELEIGQKTINLEKEKVKLQKEELNKKQNELMIYSNFAGVIQKLDKDAAQSSSQALGGQG
                     KAFLQVASKDPFQVQGTLTELQKSQIQKDQTFTVTAKANNKQKWTGKITEVSEFPTSAE
                     MAQAGGMGEATQSMSQYTYKASLDSQAGLSPGYHVSLQVSLENKTMIAVPTKSIVEKGE
                     DAFVYIEEKGKLRKQNVKKGATDGDWTEIVEGAKVGQKVVKNPSNDVYDGMEVKEK"
     gene            2552..3232
                     /locus_tag="EXW41_RS26855"
                     /old_locus_tag="EXW41_27220"
     CDS             2552..3232
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000631604.1"
                     /locus_tag="EXW41_RS26855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27220"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_215559090.1"
                     /transl_table=11
                     /translation="MITLNNVTKTYYQGKLAVPILHGISLTIQSGEFVSIMGPSGSGKS
                     TLMNMIGCLDRPTEGEYMLNDVNVLTAEESKLALIRNEYIGFVFQHFNLLPRLSAVENV
                     ELPLIYGGVKKAERRRRALEALSKVGLADRVNHLPSELSGGQKQRVAIARAIANNPAFI
                     MADEPTGALDTRSGAQVMDIFTKLNAEGTTIVMVTHEEEVAAYSSRRIVLRDGKITEDR
                     RCAV"
     gene            3229..4422
                     /locus_tag="EXW41_RS26860"
                     /old_locus_tag="EXW41_27225"
     CDS             3229..4422
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017674431.1"
                     /locus_tag="EXW41_RS26860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27225"
                     /product="ABC transporter permease"
                     /protein_id="WP_064474313.1"
                     /transl_table=11
                     /translation="MSLLDSIKIALSSILAHKLRSALTMLGIIIGVGSIITVVAIGQGG
                     EMSLKSEFSGSGNNTVPIQFKEDMNEPLSMGERPTITDEDLFEIKKIPEIKHVIATNSS
                     MEPLNLNEKKDMASVIGLDSEYFAVNQIKVKKGRALNTFDVEQGSNVVMISTDVKDIFY
                     PKENPVGKIIEIKGQPLQVIGIYKSDNGFMGMSMPEVLIPISIWPTIYGKSEIQNIVVQ
                     AETPDQLEGAGKKAVDVLNNRKSNDISGKYEIMDLKKLQEGLSQLTKIMTMVISGVAGI
                     SLVVGGIGVMNIMLVSVTERTREIGVRKALGATRSKILLQFLIEAVMLTLLGGLIGIAL
                     GYSGAYIVSKIAGWPPLVSWEVVVGGVLFSMTLGIVFGLIPANKAAKLDPIESLRYE"
     misc_feature    complement(4426..4439)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.95"
                     /tool="antismash"
     misc_feature    complement(4546..4559)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.71"
                     /tool="antismash"
     gene            4708..5136
                     /locus_tag="EXW41_RS26865"
                     /old_locus_tag="EXW41_27230"
     CDS             4708..5136
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473626.1"
                     /locus_tag="EXW41_RS26865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27230"
                     /product="hypothetical protein"
                     /protein_id="WP_064474312.1"
                     /transl_table=11
                     /translation="MFKRLAVLLIGALLLFGLAACDSVKSMTSNVTVGKVIEEFKAAGL
                     EAENPSDLPEKEFGNTRKDAKRILVPALGEDSGGRIFEFKNKEDLEKAKKYYDDLGNGN
                     QMLFSHTYAKGNFLIQMNGDMEDAQFNKYKEVMDKVIK"
     gene            complement(5268..5519)
                     /locus_tag="EXW41_RS26870"
                     /old_locus_tag="EXW41_27235"
     CDS             complement(5268..5519)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513423.1"
                     /locus_tag="EXW41_RS26870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27235"
                     /product="hypothetical protein"
                     /protein_id="WP_215559091.1"
                     /transl_table=11
                     /translation="MFKKLVVGALAVGIVLGGTESAFAYTDASQVDCSKTPPTAWQMNF
                     KTKGSMPATMVKCNKTYYLKEAYPNQDGYGTWTGVYKR"
     misc_feature    complement(5785..5801)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     CDS             5827..5943
                     /gene="allorf_19132_19248"
                     /locus_tag="allorf_19132_19248"
                     /protein_id="allorf_19132_19248"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKRYLLPFVFFLFSHPLESCHFGDSFYFVGCSSFLSNR"
     CDS_motif       5827..5895
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKRYLLPFVFFLFSHPLESCHFG"
                     /locus_tag="allorf_19132_19248_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5896..5943
                     /prepeptide="core"
                     /locus_tag="allorf_19132_19248_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.80"
                     /molecular_weight="1656.8"
                     /monoisotopic_mass="1655.8"
                     /core_sequence="DSFYFVGCSSFLSNR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKRYLLPFVFFLFSHPLESCHFG"
                     /leader_location="[5826:5895](+)"
                     /alternative_weights="1674.8"
                     /alternative_weights="1692.8"
                     /alternative_weights="1710.9"
     gene            5965..6177
                     /locus_tag="EXW41_RS26875"
                     /old_locus_tag="EXW41_27240"
     CDS             5965..6177
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS26875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW41_27240"
                     /product="hypothetical protein"
                     /protein_id="WP_088064989.1"
                     /transl_table=11
                     /translation="MNVYFKNDFGDKVFATVNKDIAGLIAALQVSSVVKLNNVNHKVTD
                     YQFEYIQYASHEEPELTVLVERIYD"
     misc_feature    7247..7262
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 22.93"
                     /tool="antismash"
     gene            7583..7798
                     /locus_tag="EXW41_RS29770"
     CDS             7583..7798
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019395593.1"
                     /locus_tag="EXW41_RS29770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_000884148.1"
                     /sec_met_domain="mature_ha (E-value: 3.1e-09, bitscore:
                     29.0, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGGINTWNTTATSTS
                     IIISETFGNKGKVCTYTVECVNNCRG"
     CDS_motif       7583..7681
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGG"
                     /locus_tag="EXW41_RS29770_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       7682..7798
                     /prepeptide="core"
                     /locus_tag="EXW41_RS29770_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.40"
                     /molecular_weight="3929.4"
                     /monoisotopic_mass="3927.0"
                     /core_sequence="INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGG"
                     /leader_location="[7582:7681](+)"
                     /alternative_weights="3947.4"
                     /alternative_weights="3965.4"
                     /alternative_weights="3983.4"
                     /alternative_weights="4001.5"
                     /alternative_weights="4019.5"
                     /alternative_weights="4037.5"
                     /alternative_weights="4055.5"
                     /alternative_weights="4073.5"
     gene            7867..10017
                     /locus_tag="EXW41_RS26885"
                     /old_locus_tag="EXW41_27250"
     CDS             7867..10017
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="EXW41_RS26885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27250"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_000723763.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1e-39, bitscore:
                     127.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIPVVLQLQQTECGLCCSNMILNYYGSRETIFNLRNEFEVGRD
                     GLSLSQLKHLFLKKGFISKIYKADIRGLKKLQLPAIIFWENKHFVVLEEISDKKIKIID
                     PAEGKRKLTTDEFLNSFSHLVLEVVPSNDFKPQFAEEVKPWEGIKQLVINKLSLTIFII
                     LTTITVLLLNLIIPYLTQKIIDGALLGSVFNDFSRIILSLILISILHLTLSITRGSLII
                     KLNIFLSEKLMGNTFRHLLRLPFKFFDLRSPGDLLYRLNSLIGVRDLISSSLIPGIVDL
                     GMMFVILIYLSSKSYTITLISLGLLFFNFLILSLSRAKVAAAVDNELVEQSKSQAILTE
                     ILFSSLFIKIAGLENKFFSKWELSYKKSLEKFKYRSQLQNIINSLSGNFQLIAPVIILV
                     TGIILYQNNALTLGEIVAIQTITTMLFNQSSSVFSAYTQLILTSSYLRRVSDITGTKIE
                     SSNNLIKNFEVNGNIELEDVYFSYTNMSNDIIKNINLSINSGEKIAIVGKSGSGKSTLA
                     KIIVGLYKHTKGNIYIDGLNINSIDQSILHKQIGIVPQDIMLFNKSIFENITMGNEKFT
                     LEDVQEAAKLAMIDKEIENMPMQYNTVISDMGLNLSGGQRQRISLARALINKPRILILD
                     EATSSLDQENEFNIMEYFKKIKCTVIIIAHRLSTIIDADKIYVIDGGNIIETGTHHELM
                     NQGGFYYHLYNKKGVSDYAYNQ"
     gene            10001..13030
                     /locus_tag="EXW41_RS26890"
                     /old_locus_tag="EXW41_27255"
     CDS             10001..13030
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="EXW41_RS26890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27255"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_215559092.1"
                     /sec_met_domain="DUF4135 (E-value: 6.9e-92, bitscore:
                     300.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.4e-62, bitscore:
                     202.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIINKQSELNNCMQLYPELQSKEELEDLIYRVSSTTIDELYKQS
                     KNDSENKFKFKSHKLNTEDVIDIGISSDLPFGSFCKSIVIDPLNLFFKNLKKIKIINDY
                     TYFTTNVADQLISRIWELSYKTLIDELKTLKNEQLLIGKTEEARFAYFHDVLLKNDEYI
                     EYLLEDNQQLSSTLRIIINRSLKNILAILHRTQAEWNNLLNQFHINNDAKLTLIDVGMG
                     DTHQDGKTVCTLHFSDGSRIMYKPRNLEVDQAFQDFLKFLNTKRITEFNTVNFFSSSSD
                     GWMEFISQKECTEEKQINEFYKKTGQYLAILYILNANDIHYENIIAHGENPILIDLESL
                     FVPKPNHYFEEFDSSFQKAQEFLHTSVNSIALLPTEITRSIDGTDLYADLGGVSFNKKQ
                     ISPYKSVILNNKNLESMDFSLKNLELEPKHNNPVLNGTTLEAYDYIQDIQDGFKSMYEW
                     AIENKEELVSKIQQLFTGKRIRFINKSTMFYSKLLDMSTYPIFSKNSFYKKLLFHRVGL
                     DGFKSGHPFLKHEYNDLLNMDVPYFSAITNTKNIYNSNGDDIGDILNDTPLERCLTKIN
                     NLSLTDLSKQLKLIETSFLNKRKGHEDCTKISFVQEKSNHPKYTINYHSYLKSAKNIGD
                     HLINEMITADENGYWIAPSLEGEQENIWSPGLVSLDLYSGNAGISIFLAQLYSCTGEMK
                     YKDAAYKAIEPIRKFITELEENSQLPFPLGVFSGTSGYLYALYKTGILLGNTELEILFF
                     DNIDKLKSFVIKDKTFDVIGGVTGTIHMLLNIAANCHVTKNKNHLIHLSIELEKHLHQH
                     PVFKDQGKIYAGFSHGIAGIMSCYALLYKNTKKPIYKNIAVELRDKLNNFYSPVQQNWY
                     NSNQNNDISNGWCHGAPGILLSFLICMECGIEIDDTYVRIAINSTKDKALGNNITYCHG
                     DLGTLSILERCANQLNDSVLSSQVELTFECLHQQYLKEIVSKNTIRHSYSFSLMIGITG
                     AGLALINKVNKIKTNILWIN"
     gene            13061..13249
                     /locus_tag="EXW41_RS26895"
                     /old_locus_tag="EXW41_27260"
     CDS             13061..13249
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019395590.1"
                     /locus_tag="EXW41_RS26895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27260"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_000910756.1"
                     /transl_table=11
                     /translation="MLKEQKLEKITGLIPESELEEHLSGESSGAGTPAIVTAISAVTAV
                     TAQSPCPTSACSKSCNK"
     CDS_motif       13061..13135
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLKEQKLEKITGLIPESELEEHLSG"
                     /locus_tag="EXW41_RS26895_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13136..13249
                     /prepeptide="core"
                     /locus_tag="EXW41_RS26895_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.80"
                     /molecular_weight="3280.7"
                     /monoisotopic_mass="3278.7"
                     /core_sequence="ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLKEQKLEKITGLIPESELEEHLSG"
                     /leader_location="[13060:13135](+)"
                     /alternative_weights="3298.7"
                     /alternative_weights="3316.7"
                     /alternative_weights="3334.7"
                     /alternative_weights="3352.7"
                     /alternative_weights="3370.8"
                     /alternative_weights="3388.8"
                     /alternative_weights="3406.8"
                     /alternative_weights="3424.8"
                     /alternative_weights="3442.8"
     gene            13327..13515
                     /locus_tag="EXW41_RS26900"
                     /old_locus_tag="EXW41_27265"
     CDS             13327..13515
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019395590.1"
                     /locus_tag="EXW41_RS26900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27265"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_000910756.1"
                     /transl_table=11
                     /translation="MLKEQKLEKITGLIPESELEEHLSGESSGAGTPAIVTAISAVTAV
                     TAQSPCPTSACSKSCNK"
     CDS_motif       13327..13401
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLKEQKLEKITGLIPESELEEHLSG"
                     /locus_tag="EXW41_RS26900_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       13402..13515
                     /prepeptide="core"
                     /locus_tag="EXW41_RS26900_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.80"
                     /molecular_weight="3280.7"
                     /monoisotopic_mass="3278.7"
                     /core_sequence="ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLKEQKLEKITGLIPESELEEHLSG"
                     /leader_location="[13326:13401](+)"
                     /alternative_weights="3298.7"
                     /alternative_weights="3316.7"
                     /alternative_weights="3334.7"
                     /alternative_weights="3352.7"
                     /alternative_weights="3370.8"
                     /alternative_weights="3388.8"
                     /alternative_weights="3406.8"
                     /alternative_weights="3424.8"
                     /alternative_weights="3442.8"
     gene            13581..16364
                     /locus_tag="EXW41_RS26905"
                     /old_locus_tag="EXW41_27270"
     CDS             13581..16364
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="EXW41_RS26905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27270"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_176546641.1"
                     /sec_met_domain="DUF4135 (E-value: 2e-87, bitscore: 286.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 7.1e-59, bitscore:
                     191.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKRTVEKHIKEYETTFGDFYRPILLNLEDTIEDLLNTYSEQINE
                     KEIILNDIIKSLLYELNRISFRTLLYEFHLTKESTETNTQDHHFKNYIQLLKDSNYITM
                     ILDKYEHLNKLINKKINFKIQLIKNIFESFSNDKSKLQQHIDNQIHTIHGIEFSHGDSH
                     NQGKSVTILQTNSGKLVYKPHNLYTDQWFYDILNVLKEDINIDIPEIPLFTVDDYGWQG
                     FISHKPCTNKEEISNYYYRMGIYLSVFYLLKTDDIHYENIMASGEYPFILDLETIVANK
                     KIHSDEEKESLMYTFLESITDSVLGTMILPVNYKFSPFDVDISALSTKEAESNIWLSYV
                     IEDAGTDNIRLIKQPSPLNKKNNKVMLHNKVANPFDFLNSIENGFSHGYDSILKNKHKI
                     TEICHSNLVNKIHVRHIPRATSVYAKFLDASTHPTYLRKTETVNMLFNKFKRGTSFTEI
                     KQAESEILALFNHDIPYFTQPLISKNLHCNEVSVIKDYFQDRPIDLVLNRLKNMDKKDK
                     EKQVYYIKMSMVTDGGGSLANIHGNQVLGFQNTEIDSILKEVGNELIDTAIIYKDTCTW
                     MIHEVTDNEKVYIGPLNYSLYDGAGLLIFLLELASYSDNKKYLQYAEMGLKGLVTDVDL
                     SKIDSYSIFHGLGSYLYLYARFYNTTQKSEYYNKLLDGVKNLNITYKKDLNIDFIGGLS
                     GMIVFLTNCYRAYGDEIFYKKAHEFAELMISIYKEKTEFLNGLAHGRAGISLSLASLYE
                     INNDAKISTEVYKVLKQENLHFNSTDNNWTDLREFINTESVYWCHGAPGISLARMKTIQ
                     YLGINDLLNKDLTCGIRKTLQDGFSDYHDSSLCHGVFGNLDILIEINKYKKCETLRHFI
                     DSTFSNYIDNLTKFGYQSGIKNSLPINNFMLGKFGIAYTLLRYKNNKIPCILSLDI"
     gene            16394..17257
                     /locus_tag="EXW41_RS26910"
                     /old_locus_tag="EXW41_27275"
     CDS             16394..17257
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="EXW41_RS26910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27275"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_215559093.1"
                     /transl_table=11
                     /translation="MSIEITNLSKSFNKRERVLDSINMNIKNGEIVGLVGPNGAGKTTL
                     MKIISGLIVQYSGEIKFSQEEYTQLGSLIEKPKYFPNKNGYYNLKYFSELYSDKDNNIE
                     EIIHSLQMENYLSKKVKDYSLGMKQRLGIALALLNNPNYLILDEPTNGMDPNGIKSILK
                     YIKGVTKKKNIGVLLSSHILDDVADISDRVYLINKGQIIDEYSSSITPEKTIKFTFNQE
                     TIIEATKILSYFGLVEKTLNTVSLTTDKDLNILLEKLGEKSIYPQGINVKKDTLEDFYF
                     KNIGAE"
     gene            17259..17978
                     /locus_tag="EXW41_RS26915"
                     /old_locus_tag="EXW41_27280"
     CDS             17259..17978
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS26915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW41_27280"
                     /product="hypothetical protein"
                     /protein_id="WP_097961232.1"
                     /transl_table=11
                     /translation="MNFSSYIRLELLRNISTVYLYLAIIASFIFGGGIVYSIYSLDGPF
                     HAHNVSGLYSTIAVLALAIFCVKIVSIDLYYGTIQLIFTNKQNRHLFLYTRLIIITVIS
                     ILFGIGCISLLWINDILNHQGFNLQIVCNTLFHYFLFGIFYTLLFLLISIFYKKPMNLL
                     IIAFFTIVLIPSILGAILNIPGLSSILKEAIMALPIYSLPTKIASLSLSITDIFVIIGL
                     SICLFVWIFYTLPKTDY"
     gene            18025..18738
                     /locus_tag="EXW41_RS26920"
                     /old_locus_tag="EXW41_27285"
     CDS             18025..18738
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014573.4"
                     /locus_tag="EXW41_RS26920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27285"
                     /product="flavodoxin family protein"
                     /protein_id="WP_097961231.1"
                     /transl_table=11
                     /translation="MKKVVAYVASRNNSSRPVRITENLLTELKRSLNHRINTTLITPLT
                     HNVLPPTGCKSCFNQGICPSDSLTYDDTTLIKNELLEADLIFLVSPVYSHNVSGDMKNL
                     IDRISYWAHIFKLSGKPIILLASAESNGAKYVINYMNRVFTAMGATIIGQETFLNTVED
                     SYKGKVDIIINLSKKILLKNVFLSPTEQQENLFQYLKQTISTYNNEHFEYKYWLQNGLF
                     KKNSLEEYFIEQQKN"
     gene            complement(18782..18910)
                     /locus_tag="EXW41_RS30000"
     CDS             complement(18782..18910)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS30000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_257131401.1"
                     /transl_table=11
                     /translation="MNSESFAFALGLAVVFGLLYSSVLAAIIGGAAGFVVGKYSKK"
     misc_feature    18888..18906
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 26.06"
                     /tool="antismash"
     misc_feature    19073..19087
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(19211..19423)
                     /locus_tag="EXW41_RS26925"
                     /old_locus_tag="EXW41_27290"
     CDS             complement(19211..19423)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS26925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW41_27290"
                     /product="hypothetical protein"
                     /protein_id="WP_252196063.1"
                     /transl_table=11
                     /translation="MNDVKQKMCKVCETSYLLKFQVGYVSNNHFSFGCPTCGVMLEGII
                     NVDNKEAKFNWNFDNLVDYSGDEKF"
     gene            complement(19711..20463)
                     /locus_tag="EXW41_RS26930"
                     /old_locus_tag="EXW41_27295"
     CDS             complement(19711..20463)
                     /GO_component="GO:0005694 - chromosome [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003916 - DNA topoisomerase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006265 - DNA topological change [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013555.4"
                     /locus_tag="EXW41_RS26930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27295"
                     /product="topoisomerase DNA-binding C4 zinc finger
                     domain-containing protein"
                     /protein_id="WP_215559094.1"
                     /transl_table=11
                     /translation="MIFTKVFQHLNEFCKNDTSQSALFNFEYNSGLFTGIYLPIPRSIL
                     ITCKNTNASWVLESNENDNVNIYIPKDIFQQVKDYVCTIDKKGDSTTYPFFEELQKHLL
                     NLSLNIFKEAPTDLLLKNARTAKTNDTKYDEKGKGDRVYFDHWRRNKVRNVSKLNLQKT
                     RRWFGKEIYDYCKKFNITSVWQPEPSKNIKQHLLFFDTTEAKVQLKDKRMTCPKCSKVL
                     IIKTNSLSKGQFIGCTGYPSCRHTENAD"
     gene            20645..21172
                     /locus_tag="EXW41_RS29775"
     CDS             20645..21172
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013540.4"
                     /locus_tag="EXW41_RS29775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_252196064.1"
                     /transl_table=11
                     /translation="MKNLKLSRKLLGFTQKSLGEALGVSNQMVKNWELGVKNPRLENLI
                     SIADILTKEAREIIEKEWLEVPREKISIDYLLGRSMDEGTSVLLTRIWGLSTYYSYRNL
                     GTAIYYLPDSPSNNNEEVLNQVLKIGLIDSPDELVQYSRTPHFYYDPYSIGDYSYGGST
                     LVEITDLFWENE"
     CDS             complement(21355..21435)
                     /gene="allorf_34660_34740"
                     /locus_tag="allorf_34660_34740"
                     /protein_id="allorf_34660_34740"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MKRHIEKKHKIEFSNSTTSVAVYCIK"
     CDS_motif       complement(21394..21435)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKRHIEKKHKIEFS"
                     /locus_tag="allorf_34660_34740_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21355..21393)
                     /prepeptide="core"
                     /locus_tag="allorf_34660_34740_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.60"
                     /molecular_weight="1213.4"
                     /monoisotopic_mass="1212.6"
                     /core_sequence="NSTTSVAVYCIK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKRHIEKKHKIEFS"
                     /leader_location="[21393:21435](-)"
                     /alternative_weights="1231.4"
                     /alternative_weights="1249.4"
                     /alternative_weights="1267.4"
     gene            complement(21507..21701)
                     /locus_tag="EXW41_RS26940"
                     /old_locus_tag="EXW41_27305"
     CDS             complement(21507..21701)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000367312.1"
                     /locus_tag="EXW41_RS26940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27305"
                     /product="aspartyl-phosphate phosphatase Spo0E family
                     protein"
                     /protein_id="WP_215559095.1"
                     /transl_table=11
                     /translation="MDMKLLHDMIEDQKKELSYLVKKYGFSHKKVIDFSQKLDLLIYEA
                     MGKYRLDQKMRIKKESLIQ"
     misc_feature    21857..21874
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 25.17"
                     /tool="antismash"
     gene            complement(21937..22101)
                     /gene="hfq"
                     /locus_tag="EXW41_RS26945"
                     /old_locus_tag="EXW41_27310"
     CDS             complement(21937..22101)
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_process="GO:0016070 - RNA metabolic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="hfq"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000990401.1"
                     /locus_tag="EXW41_RS26945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27310"
                     /product="RNA chaperone Hfq"
                     /protein_id="WP_215559096.1"
                     /transl_table=11
                     /translation="MMHTQEKFYAKLIEEKKEVTIFLINGVRVPGKIIAVDKFSVLVLS
                     NGKQMFLYK"
     gene            complement(22098..22955)
                     /locus_tag="EXW41_RS26950"
                     /old_locus_tag="EXW41_27315"
     CDS             complement(22098..22955)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000055172.1"
                     /locus_tag="EXW41_RS26950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27315"
                     /product="hypothetical protein"
                     /protein_id="WP_215559097.1"
                     /transl_table=11
                     /translation="MSLLQQHFEERREYIFNRLKQPEYMERSIEKVRQAQKEIKNTVRT
                     IKDLLLLDKTTDPCLPEVAQFSLQHIMNSESFENVKKLVPSSIKKLSEEERAKVLDETL
                     SVANQIMNLERTVFIMMFNAKEKILMDAYKKKPRSQTELHYDVADKEGFDKAFYEERID
                     SLQNDIRVLSFKKLCENEPAPEDLELFKQRYETIILPKVQEIVSLIEPSLIDVDVFLNS
                     VIEYGVGEITLDEMIQKLHKNLSLFHELSKVEYCPTVELTVKEYVFLEAMNRSEKGEEL
                     QPSK"
     gene            23257..23663
                     /locus_tag="EXW41_RS26955"
                     /old_locus_tag="EXW41_27320"
                     /pseudo=""
     CDS             23257..23663
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016123544.1"
                     /locus_tag="EXW41_RS26955"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="EXW41_27320"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNNSYEIIDNQILFEG"
     gene            23674..23997
                     /locus_tag="EXW41_RS26960"
                     /old_locus_tag="EXW41_27325"
     CDS             23674..23997
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000934651.1"
                     /locus_tag="EXW41_RS26960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27325"
                     /product="hypothetical protein"
                     /protein_id="WP_215559098.1"
                     /transl_table=11
                     /translation="MLNRKETISFQAFMDQSYKKKKPTKIYSIGPISPFAFFHMSSPLF
                     HTYVALGIVGGLTIGAVLLEKYLVRNDYIFASNLLSNGLYYGVRIGGIGFIGYAFIRIL
                     LML"
     gene            24010..25173
                     /locus_tag="EXW41_RS26965"
                     /old_locus_tag="EXW41_27330"
     CDS             24010..25173
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000679433.1"
                     /locus_tag="EXW41_RS26965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27330"
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /protein_id="WP_215559099.1"
                     /transl_table=11
                     /translation="MKGWLKKKKYKYQLEEVFKKAKLYDEHITRGGKVPIYPKIHDVFE
                     ENESVRYTFTLPNGVDPAQIHKKWFCFQQILGENLMMEGTIKRFVLHVFHSDARLQPYN
                     YSYKQWQPLLKQYRLPVVVGRDQFGNAIVYDMVDSNTPHLLIAGETGSGKSSMVRVILA
                     TLIQHMSPDHLHLYLGDLKNSEFHFLRRVKHVKYVCMEEHEMTSMLSKLWKEVLHRRKV
                     MEEYELGHIDEYNQITKDKPLPYIFIAIDEVAMLQDEKECVTIIEKISAVGRSLGIFLM
                     LSMQRPDAKILDGKLKLNLTVRMGFKCADLINSNIVGTPGSENLSQSGQMILKLDGLKK
                     VQAPYLALDQAKEIIEPYRLSKEQSIKKEEPEHQEDKIFGVLDDANE"
     gene            25157..25810
                     /locus_tag="EXW41_RS26970"
                     /old_locus_tag="EXW41_27335"
     CDS             25157..25810
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002105922.1"
                     /locus_tag="EXW41_RS26970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27335"
                     /product="replication-relaxation family protein"
                     /protein_id="WP_215559100.1"
                     /transl_table=11
                     /translation="MMLTNRDKQIIGHLQQFRCMSRDDIIDLHFRNVKNAVTCCNTVTK
                     RLSREGYIDVDTSQRPYVYFPYPNTIRKGSQKIRHFLAIVDVYKQLLRTERPKIFQVEP
                     KYKKGYMEPDIFTIWRKSPFFIEVQNSIYNKATIQTKIKRYESYFRSMEWKKESWQPKH
                     NMVFPSLLILTDLKYPISSSNFRIFQAPSIQHFLTQVQQPKDISIQIGSVKAKL"
     gene            complement(25839..26060)
                     /locus_tag="EXW41_RS26975"
                     /old_locus_tag="EXW41_27340"
     CDS             complement(25839..26060)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000466110.1"
                     /locus_tag="EXW41_RS26975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27340"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_088065032.1"
                     /transl_table=11
                     /translation="MFFRKNRTKLKKWLDRQGIEQQELAKKSKVSVQTISKACRDTDYI
                     PKPEIMKKILNTIRKIDPHAKINDFWDM"
ORIGIN
        1 tttgaaagag gaaaaaagaa aatagaagaa ttatatgtaa atggaataaa aagagcaaaa
       61 atagagtcta ttttaattcc attaatgact gtatcaatta ctcttattat agtggttgtg
      121 gttggatttg gttcatatag agtaagtgaa ggttatcttt cttctggtga attattagca
      181 tttattttat atttatttca aattgtagga ccagtgggtg tgatgagtcg ctttattaca
      241 aatgttcaat ctgctaaagg gtctacggaa agaattttta atattttaga tgaaaaagat
      301 gaaaaaaata aagatgactt tttagaggaa ccgtcatttg gaacattaga atttaaggat
      361 attggttttg cttatgatga aaaaagtatt tttgaaaata ttaatttgaa aattatgcct
      421 aatactgtta ctgcacttgt tggtcctagt ggagttggaa aaactacttt attttattta
      481 ttagaaagat tttatgatcc tcttaaaggg gaaattttat tagatggaaa atctcatttg
      541 aatatagacc ttgataagtg gagatctatg tttagttatg tttcacaaga ttgccctata
      601 ttagtgggga caattcgtga aaatattaca tatggtattc aaagagaagt ttctgaagat
      661 gaaattataa atgcatctat tttggcaaac tgtcatgagt ttataacaaa tttttcagat
      721 ggatatgata ctgttttagg tgaaagagga attaatcttt caggaggtca aaaacaacgt
      781 atatctattg ctagggcatt tttaagagat actccatttt tattattgga tgaggctact
      841 gcaaatcttg atactaattc agaaaatatg attaaacatg cattagataa tcttatttat
      901 aaaaaaacaa ctattgtaat tgctcatcgt atttctacta ttcaaaatgc tgatcaaatt
      961 gttgttttag atcagggaga agtttcgggg tttggtacac acgatcaatt aattaagagt
     1021 aataaactat atcaactttt atcaaatcaa caaaaaatga cttcttaaat aaaataaata
     1081 tagctcttcc taattaggaa gagctatatt tattagtttt tattattttt gtaccatgtc
     1141 aatttagtaa taagatattg aataccaaat aggaaagcga aaagtatact atacataaaa
     1201 ttaattaaat ttaaatgaga tatatattat tactttattg aaattataat ttacttaaag
     1261 taattttttt aaatttttgg aaaaaatgtg tatttaatgt tgtttattta tatataatac
     1321 cttattattt aaatataaaa atcaaaaaat gaaggggcaa gaaaatgtta caaaatacgg
     1381 ttcgtactcc aaaaaagaaa aagaaatgga taataattgg agttatagca ttaattatta
     1441 ttgttgctgc tattaatatt tttgttatgc aaggggaaaa aagggctaca gtaaagacgg
     1501 attctgttag ttttgaaaag gtaacagaac gtaagtttaa taatacaaag ttaatttctg
     1561 gtcaggtgaa gcctggtaat attgaaagtt tctacgcgga tccgactaaa ggaaaagtga
     1621 aagatattgc ggtgaaagaa ggacaagagg tagaaaaggg aacgaaatta ttctcttatg
     1681 ataatgagga aattaattta caggtgaagc aagctgagct tgatcagaag atggcggata
     1741 tgcgttatga ccaagggaaa aaaaagattg attcattgaa gaaagagatt aagaaggcaa
     1801 aagatagtgg ggctggtaaa gaagtaacag actcaatgga agagcaagta agcgagttag
     1861 aaatagggca aaaaacaatt aatcttgaga aagaaaaagt gaagttgcaa aaagaagagt
     1921 taaataaaaa gcagaatgag cttatgattt atagtaattt tgctggtgtt attcaaaagt
     1981 tagataaaga tgcagcacaa agttcatctc aagcattagg tggtcaagga aaggcgtttt
     2041 tacaagttgc ttctaaagat ccgtttcaag tgcaagggac gttaactgag cttcagaagt
     2101 cacaaattca aaaggatcaa acattcactg taactgcgaa agcaaataat aagcagaagt
     2161 ggacaggtaa gattacagag gtaagtgagt tcccaacgag tgcagaaatg gctcaagctg
     2221 gtggtatggg tgaagcgact caaagtatgt ctcaatatac atataaagca agccttgata
     2281 gtcaagctgg tttatcacca ggttaccacg tttctctgca agtaagttta gagaataaga
     2341 cgatgattgc tgttccaact aagagcattg ttgaaaaagg cgaagatgca tttgtttata
     2401 tcgaagaaaa aggaaagctc cgtaaacaaa atgtgaaaaa aggtgctact gatggagatt
     2461 ggacagagat tgtagaaggc gcaaaagtgg gacaaaaggt ggttaaaaac ccttccaatg
     2521 acgtatatga cggaatggaa gtgaaagaaa aatgattacg ttaaataatg tcactaagac
     2581 gtattatcaa gggaaattgg cagttccaat tttacatggc attagtttaa cgattcaaag
     2641 tggtgagttt gtttctatta tgggaccgtc tggttcgggg aaatcaacgt tgatgaatat
     2701 gattggttgt ttagatcgtc caacagaagg cgaatatatg ttgaatgatg tgaatgtttt
     2761 aacagcagaa gaatcaaaac tagctttaat tcgtaatgaa tatattggtt ttgtgtttca
     2821 acattttaat ttattacctc gtctttcagc agtggaaaac gtcgaacttc cgctgatcta
     2881 cggtggtgtg aaaaaagcag aacgtcgtcg aagagctctt gaagcactta gtaaagttgg
     2941 tttagcagac agggttaacc atttgccaag tgagttatca ggtggacaga agcagcgtgt
     3001 tgctatcgca agggcgattg ctaataatcc ggcgtttatt atggcggatg agccaactgg
     3061 tgcgcttgat acgagatctg gtgcacaagt tatggatatt ttcacgaagt taaatgcaga
     3121 aggtacgacg attgttatgg ttacgcatga agaagaggta gcagcttatt catctcgccg
     3181 gattgtatta cgagatggga aaattacaga agatagaagg tgtgcagtat gagtttacta
     3241 gatagtataa aaattgctct atcttctata ttagctcata aattacgttc agctcttaca
     3301 atgcttggta ttattattgg tgttggttct attattactg ttgttgcaat tggacaaggt
     3361 ggagaaatgt ctttgaaatc tgagttttca ggttcgggga ataatacagt tcctattcaa
     3421 tttaaagaag atatgaatga gcctttgtcg atgggggaaa gaccgacaat aacagatgaa
     3481 gatctttttg aaatcaaaaa aatccccgaa attaaacatg ttatagctac taattcaagt
     3541 atggaacctc ttaacttgaa tgaaaaaaag gatatggcaa gtgttatagg gcttgatagt
     3601 gaatattttg cagtaaatca aataaaagta aaaaaaggta gagctttaaa tacatttgat
     3661 gttgaacaag gtagtaatgt tgtcatgatt agcacagatg taaaagatat tttttatcca
     3721 aaagaaaatc ctgttggtaa gattattgaa attaaaggtc agcctttaca agttattggt
     3781 atttataaat ctgataatgg ttttatgggt atgagcatgc cagaagtatt aattccaatt
     3841 tctatttggc caacaatata tggaaaaagt gaaattcaaa atattgttgt tcaagcagag
     3901 acgcctgatc agcttgaagg agcagggaaa aaagcagttg acgtgttaaa taatcgtaaa
     3961 tcaaatgata tttctggaaa atatgaaatt atggatctta aaaaattaca agaaggtctt
     4021 tcacaattaa caaaaatcat gactatggtt attagtgggg tagcgggtat ttcattagtt
     4081 gttggtggta ttggtgtaat gaatattatg cttgtatcag ttacagagcg tacacgtgaa
     4141 attggtgtta gaaaagcact tggagcaaca cgtagtaaaa ttttattgca atttttaatt
     4201 gaagccgtta tgttaacact tcttggtgga ttgataggaa ttgctcttgg gtatagtgga
     4261 gcttatattg tttcgaaaat cgcgggatgg cctcctcttg tttcatggga agttgttgtt
     4321 ggaggagtat tattttctat gactcttggt attgtttttg gattaattcc agcaaataaa
     4381 gcagcgaaat tagatcctat tgaatcatta cgttatgaat agatatgcat aattatacat
     4441 ctatttttgt gaataaattg gtatattaat ttattgaact actcgccact tagcaaggct
     4501 tgaagtggga gcttctcagt tccaagacga aagtaacctt tcgtctccct gagcgttact
     4561 tcgggtggtt tcatccccag aactaaattt gatgatgaat tgtaacaaaa aatcttattt
     4621 tttcgtaaca caatatataa taatatacag atttataatt tgttattatg tttacggatt
     4681 tatttacatt aggaggaatg aacaactatg tttaaaagat tagcagtatt acttattggc
     4741 gctctattat tatttggttt agctgcttgt gacagcgtta aatcaatgac aagtaatgtt
     4801 acagttggta aggtaattga agaatttaaa gctgcaggat tagaagccga aaatcctagt
     4861 gacctaccag aaaaagaatt tggaaatact agaaaagatg caaagcgcat tcttgttccg
     4921 gcattaggtg aagatagcgg cggtagaata tttgagttta aaaacaaaga agatcttgaa
     4981 aaagctaaga aatactatga cgatttaggt aatggtaatc aaatgctatt ctctcatact
     5041 tacgcaaaag gtaatttcct tatacaaatg aatggtgata tggaagatgc ccaatttaac
     5101 aaatataaag aagttatgga caaagtaatt aagtaagtta aagaattcgc tttcattttc
     5161 ctaaaaccag gttagaatta tctttggatg ggagtccaat acatattatt aaaatttaag
     5221 tggttattaa gtcggagaaa ggcaccctaa ggtgcctttt ctctttgtta acgtttgtaa
     5281 acaccagtcc aagtaccata tccatcttga ttaggataag cttcttttaa ataatatgtt
     5341 ttgttacatt taaccattgt cgcaggcatt gaaccttttg ttttgaaatt catttgccat
     5401 gctgttggtg gagttttgct gcaatcaacc tggcttgcat cggtgtaggc aaaagcgctt
     5461 tctgttccac ctaatacaat acctactgct aaagctccaa ctactaattt cttgaacata
     5521 aaaattcccc ctcaaatatt ttttataact tgcacaacaa tcctaatgtg ttttacaaat
     5581 aatgttagtt aattaaactt tataaaaaat attataatat tcagaaataa gaatataaaa
     5641 cattaaataa ctttatttaa acctagttct aaaatcagaa cgtgattatg cttattaaca
     5701 aagatattat ttcgtctgtt caatctttta cagaagaacg gatgaaaatc taataggcat
     5761 gagaagaaaa cagtctttga tatattgggt gtcgtgtaca attatttcgt tattcaccag
     5821 ctttaaatga agagatactt attgccattt gttttctttc ttttctccca tccccttgaa
     5881 agctgtcact tcggtgatag cttttatttt gtaggatgtt cttcttttct gtcgaataga
     5941 tagattggga gaggtgaaga taatatgaat gtatatttta aaaatgattt tggtgataaa
     6001 gtatttgcta cagttaataa agatattgca ggattaattg cagcactgca agtttcgagt
     6061 gtagtgaaat tgaataatgt aaatcacaaa gtaactgatt atcaatttga atacattcaa
     6121 tacgcgagtc atgaagaacc tgagttaaca gtattagttg aacgaatata cgattaagca
     6181 tccataacgg gtgctttttt tctttgttat atagaaatta tacattaaaa gtgaatttgg
     6241 ataggaggat aacatatgga ggaagagtcc tgctgaaata aattagaaat ttaagaaggc
     6301 gcatttcgaa taaaaactga acaaaaatag agatagttaa caaattacag ttgcgtgtaa
     6361 ctatatagac gtttttgtta tataaattac tacaatacat aatcatatgt ctttctataa
     6421 gaatcctaca ttcttcttta tttacctata cttaaatttt tctcaattta ttatgatata
     6481 gatatcgttt aaaagtatat tgtgcaaaat aattaattgg aatttttgta tgaatctatc
     6541 gattcaatat taactactca ccacctaaaa ttatatctat attcacaatt taattgataa
     6601 ataaaacgtg gaatatttaa attattgatt ataatcacct tgaaactacg cttttaaagg
     6661 gtgtttttgt gtctaataaa tacaattatt cgctcaaaaa attcgtatat ttttatatca
     6721 aaattcacta aaatataggt gttataaatt cacaaaacaa aaaggaagcc ataaaggttt
     6781 cctttttgta tatgcttcaa aaggaagact ttaataaatc taataatgaa ttcctgtgac
     6841 tcatcctcat atctgacaca ttaattcata gctacatcta gggatctata tacccctttc
     6901 aaataaatgt aatatttgca ccagaacctt atctattaaa tatatacttc caaacggcct
     6961 taatcactcc tacatttggc atattatccc tcctttgtat aaaataagtg tatcattgtt
     7021 gaattaataa gaacagtgta ttatttaaat agtataaaaa ataaaaatac tttatgtttt
     7081 ttgctacata tatgatttag tcatatcatg tttatatttt aaatctgtat ctctttgctc
     7141 caagtgccct tcagtaaatt cataaaccac gaaattatta atatacaatt tcaggaaaat
     7201 aacactaaaa caaactaaaa agtcatatat attaaccact tctcatttaa agtatttttc
     7261 acaatccaat aaattcaaaa aaatcgaaat atataaatat aactaaccta gtttaacaga
     7321 aaaatcattt ttttaaaacc cttttttttc catggttaat aatgttaaga tttaaatgta
     7381 gataaacgtt agttaatatg aatattcgaa gagcgcaatt tattttatat tactataaaa
     7441 aatgctttaa acatgttttt aatttgcgat cagtatttgt taaataatag tttagtatga
     7501 acctgcattt aacactctta catatagcta tacggatatc tacacaaata aatatcataa
     7561 aaataagaaa tgagggatta ttgtgcttga tattattaaa aacagaaaaa aagttaaaga
     7621 aaacttagaa ttacctgata ctttattaga agaagttgaa gaacactcag ctatgggtgg
     7681 tataaacaca tggaatacta cagctacttc aacttctatc attatcagtg aaacatttgg
     7741 taataaagga aaggtttgta cttacacagt tgaatgtgta aataattgta gaggttaatt
     7801 aaaaaatgag agtaataatt tttattactc tcattatcta ctaagaaagg tttctattaa
     7861 aataaaatga aaaaaattcc agttgtttta caactccaac aaactgaatg tggattatgc
     7921 tgtagtaaca tgatattaaa ttattatggc agtcgagaaa ctattttcaa cttaagaaat
     7981 gaatttgagg ttggaagaga tgggttaagc cttagtcaat taaaacactt gtttttgaag
     8041 aaaggtttta tctcaaaaat ttacaaagct gatattaggg gacttaaaaa acttcaactc
     8101 cctgcaataa tcttttggga aaacaaacat tttgtcgttt tagaagagat ttcggacaaa
     8161 aagattaaaa ttattgatcc cgctgaaggt aaacgaaaac ttaccaccga tgagttttta
     8221 aatagttttt cacatttggt tctagaggta gtcccaagta atgactttaa gccacaattt
     8281 gctgaagaag taaagccttg ggagggaata aaacaattag tcataaacaa actatcttta
     8341 actatattca ttattttaac aacaataacc gttttactac tcaatttaat tattccatac
     8401 ctcacgcaaa aaattataga tggtgcttta ctcgggtcag tatttaatga tttttctagg
     8461 attattttaa gtctcatact tatatctata ttgcacctaa ccctatcaat tacaagagga
     8521 tctcttatta ttaaactgaa catcttttta agtgaaaaac ttatggggaa cacattccgt
     8581 catttattac gattaccatt taaatttttc gatttaaggt ctccaggtga tttattgtat
     8641 agactgaata gtcttattgg agtaagggat ttaatttcta gtagtttaat accaggaatc
     8701 gttgatttag gtatgatgtt tgttattcta atttatttgt cttcaaaatc atacacaatt
     8761 acacttatca gtttaggatt attatttttt aactttttaa ttttaagttt aagtagagcc
     8821 aaagttgctg cagcagtaga caatgaactc gttgagcaaa gtaaaagtca ggctatcctg
     8881 actgaaattc tattttctag tttatttatt aaaattgcag ggttagaaaa taaatttttt
     8941 tctaagtggg aacttagcta taagaaaagt ttagagaaat ttaaataccg ttctcagttg
     9001 caaaatataa taaactcttt atctggtaac tttcaactta tagctcctgt cataatctta
     9061 gtaacaggta taattttata ccaaaataat gcattgacac taggtgaaat tgtggctatt
     9121 caaactatta caacaatgct atttaatcaa tctagttcgg tattttctgc ctatacacag
     9181 cttattttga cttcatctta tttaagaaga gtgagtgaca ttaccggaac caaaatagag
     9241 tcttctaata atctcattaa aaatttcgaa gttaatggaa atatagagtt agaagatgtt
     9301 tatttctcat atacaaatat gagcaatgat attatcaaaa atattaactt atctattaat
     9361 agtggtgaaa aaattgccat tgttgggaaa tccggttctg gaaaaagtac attagcaaaa
     9421 atcatagttg gactatataa acataccaaa ggaaatatct acatagatgg tctgaatatc
     9481 aattccattg atcaaagcat attacataaa caaataggta ttgttccaca agatattatg
     9541 ttattcaata aaagcatctt tgaaaatata acaatgggaa atgaaaaatt cacattagag
     9601 gatgtgcaag aggcagcaaa acttgcaatg attgataaag aaatcgaaaa catgcctatg
     9661 cagtataaca cggtaataag cgatatgggc ttgaacttat caggtggtca acgtcagcgt
     9721 atttctttag ctagagctct cattaataaa ccacgaatat taattttaga tgaggcaaca
     9781 agctcattgg atcaagagaa tgagtttaat attatggagt attttaaaaa gattaagtgt
     9841 acagtaatta ttatagctca tcgactttca actattatag acgccgacaa aatatatgtt
     9901 attgatggtg ggaatatcat agagactggg actcatcatg aattaatgaa tcaaggtggc
     9961 ttctattatc acttatataa taaaaaagga gtaagtgatt atgcctataa tcaataaaca
    10021 aagcgaattg aacaattgta tgcagttgta tcctgaatta caaagtaaag aagaactaga
    10081 agatttaatt tatagggttt catctactac tatagatgaa ctctataagc aaagtaaaaa
    10141 tgatagtgaa aataaattta aatttaaatc tcataaacta aatactgaag atgtaattga
    10201 tataggtatt tcatcagatt taccttttgg ttcattttgt aaatctatcg ttatcgatcc
    10261 tttaaatctt tttttcaaaa atttaaagaa aattaagatt ataaatgatt atacctattt
    10321 cacaacaaat gttgccgatc agctaatctc aagaatatgg gaactgtcat ataaaacttt
    10381 aattgatgaa ttaaaaacat taaaaaatga acaattatta attggaaaaa cagaagaagc
    10441 gcggttcgca tactttcatg atgttttatt aaaaaatgat gaatatatag aatatttatt
    10501 ggaggataat caacaattat caagcacctt acgtatcatc ataaacagaa gtttaaaaaa
    10561 tattttagcc attttacata gaacacaagc tgaatggaat aacctattaa atcaatttca
    10621 tataaataat gatgcaaaac ttactcttat tgatgtagga atgggagata ctcatcaaga
    10681 tggaaaaaca gtttgtacac ttcatttttc agatggttca cgaattatgt ataagccaag
    10741 aaatttagag gtggatcaag cattccaaga ttttttgaag tttctaaata caaagagaat
    10801 aactgaattt aatactgtta actttttttc tagtagttca gatgggtgga tggaattcat
    10861 ttcacaaaaa gaatgtactg aagaaaagca aattaatgaa ttttacaaaa agactgggca
    10921 gtacctagcc atactatata ttttaaatgc aaatgatatc cattatgaaa atattattgc
    10981 acacggggaa aatccaatat taatcgattt agagtcttta tttgttccaa aacctaatca
    11041 ttattttgag gaatttgaca gcagttttca aaaggctcaa gaatttttac acacatctgt
    11101 aaatagtatt gcacttctgc caacagaaat aaccagatcc attgatggta ctgatttata
    11161 tgcagattta ggcggtgtga gttttaataa gaaacaaata tctccctata aatcagtgat
    11221 attaaacaac aaaaatttag aaagcatgga tttctcttta aaaaatttag aattagaacc
    11281 aaaacataat aatcctgttt taaatggtac aacattagaa gcttatgatt atattcaaga
    11341 cattcaagat ggattcaaaa gcatgtatga atgggctatt gaaaataaag aagaattagt
    11401 aagtaaaatt caacaattat ttactggtaa aagaattcga ttcatcaata agagcactat
    11461 gttttattca aaattattag acatgtcaac ataccctatc tttagtaaaa attcttttta
    11521 taagaaatta ctattccaca gagttggttt agatggattt aaatcgggac accctttctt
    11581 aaaacacgaa tataatgatt tattaaatat ggatgttcca tatttttctg caataactaa
    11641 cacaaaaaac atctataatt ctaatggtga tgatattggg gacatattaa atgatactcc
    11701 tttagaacgt tgtttaacaa agataaacaa tttatcctta acagatcttt ccaaacaact
    11761 aaaattaatt gaaacgtcat ttttaaataa acgtaaaggg cacgaagatt gtactaaaat
    11821 ctcatttgta caagaaaaat ctaatcaccc aaaatatacg ataaattatc attcctatct
    11881 gaaaagtgct aagaatatcg gcgatcattt aattaatgaa atgattaccg cggatgaaaa
    11941 tggatattgg attgctccct ctctggaagg agaacaagaa aacatctggt ctccaggtct
    12001 cgtaagttta gatttatata gtggaaacgc tggaatttca atatttctag ctcaattata
    12061 ttcatgtaca ggtgaaatga aatacaagga tgccgcttat aaggcaattg aacccataag
    12121 aaaatttata acagaattag aagaaaatag ccaactacct ttccctttag gagtattctc
    12181 tggaacctcc ggttatcttt atgctcttta taagaccggt attttactag gaaatactga
    12241 acttgaaatt ttattttttg ataatattga taaattaaaa agttttgtca taaaggataa
    12301 aacttttgat gttataggtg gcgtaacagg tacaattcac atgttattaa atattgcagc
    12361 taattgtcat gttactaaga ataaaaatca cttaattcac ctttctatcg aactagaaaa
    12421 acatttacat caacatcccg tatttaaaga tcaagggaaa atttacgctg gtttctctca
    12481 tggtatagca ggaattatgt catgctatgc attattatac aagaatacaa aaaaaccaat
    12541 atacaaaaat atcgctgtag aattaagaga taaattaaat aatttctatt ctccagttca
    12601 acaaaactgg tataacagca atcaaaataa tgatattagt aatggttggt gtcatggagc
    12661 tcctggtata ctactctctt tcttaatttg tatggagtgc ggaatagaaa tagatgacac
    12721 ttatgtcaga attgctataa atagtacaaa agataaagcc ttaggtaata acatcactta
    12781 ttgtcatggt gatttgggta ctttatctat acttgagaga tgcgccaatc aattaaatga
    12841 ttctgttctc tcttcacagg tcgaattaac atttgaatgt ttacaccaac aatatctaaa
    12901 agaaatagtt agtaaaaata caattaggca ttcatattca tttagcttaa tgattggtat
    12961 taccggtgct ggtctagctt taattaataa agtgaataaa ataaaaacta atattctatg
    13021 gattaattaa tcctctcgta cttgaaagga ggtgaaacat atgttaaaag aacaaaaatt
    13081 agaaaaaatc acagggctta tccctgaatc agaacttgaa gaacatcttt caggagaaag
    13141 tagcggtgca ggaactccag caattgttac tgctatcagt gccgtcactg ctgtaactgc
    13201 tcaatctcca tgtccaacat ctgcatgttc aaaatcatgc aataaatagc ttagatacat
    13261 aaaaattgta ccgataattt atgtattaac ctattctatt ttaactttga aaggaaatga
    13321 tgaataatgc taaaagaaca aaaattagaa aaaatcacag ggcttattcc tgaatcagaa
    13381 cttgaagaac atctttcagg agaaagtagc ggtgcaggaa ctccagcaat tgttactgct
    13441 atcagtgccg tcactgctgt aactgctcaa tctccatgtc caacatctgc atgttcaaaa
    13501 tcatgcaata agtaataagt aataaaatag attgtttcga ttcaaaaatc gaaacaatct
    13561 atttattagg aggaaaaact gtgtacaaaa gaaccgtgga aaaacacata aaagaatacg
    13621 agactacttt tggagatttt tatagaccaa tattattgaa tctcgaagat acaattgaag
    13681 acttactcaa tacatacagt gaacaaataa atgaaaaaga aataattcta aatgatatca
    13741 taaaatcttt attatatgaa ttgaatagaa tttcattcag aactttatta tatgaattcc
    13801 atttaactaa ggagagcact gaaacaaata cccaagacca ccacttcaaa aattatatac
    13861 aattattaaa ggattctaat tatattacaa tgatattaga taaatacgaa catttaaaca
    13921 aattaataaa caaaaaaatc aacttcaaaa tacaattaat taaaaatatt tttgaaagct
    13981 tttcaaatga caaatctaaa ttacaacaac atatagacaa tcaaattcac actatacatg
    14041 gtattgagtt tagccatgga gattcgcata atcaaggtaa atcagtaacc attcttcaaa
    14101 ctaatagtgg aaaattagta tataaacctc ataatttata tactgaccaa tggttttatg
    14161 atattttaaa cgttttgaaa gaggatatta atattgatat accagaaatc ccgctattta
    14221 ctgtagatga ttatggatgg caaggtttca tatctcacaa accatgtact aacaaagaag
    14281 aaatttcaaa ttattattat agaatgggaa tatacttatc cgttttttat cttcttaaaa
    14341 ctgatgatat ccattatgaa aatattatgg cctctggaga atatcctttt atacttgatt
    14401 tggaaactat agtcgctaat aaaaaaattc actccgatga agaaaaagaa tctttaatgt
    14461 atactttctt agaatctata actgactccg tcttaggaac aatgattcta ccagtaaact
    14521 ataaattttc accatttgac gtagatattt ctgcattatc tactaaagaa gccgaatcaa
    14581 acatttggtt atcttatgtt atagaagatg cagggacaga taatattcga ctaataaagc
    14641 agccatctcc actaaataaa aaaaataata aagtcatgtt acataataaa gtagctaatc
    14701 cttttgattt tctcaacagt attgagaatg gattttcaca tggatatgat agtattttaa
    14761 aaaacaaaca taaaattaca gaaatatgcc actcaaattt agtaaataaa attcatgtaa
    14821 gacatatccc acgggctaca agtgtatatg caaagttttt agatgcttct acgcatccta
    14881 cttaccttcg caaaacagaa acagtaaata tgctatttaa caaattcaaa agaggtactt
    14941 cctttacaga aataaaacaa gctgaatcag aaatattagc tttatttaac catgatattc
    15001 cttattttac tcagccgcta ataagtaaaa atcttcactg caatgaagtg agtgtgataa
    15061 aagattattt tcaagacaga cctatcgatt tagttcttaa cagattgaaa aatatggata
    15121 aaaaagataa agaaaagcaa gtatactaca taaaaatgtc aatggtcact gatggaggtg
    15181 gtagtcttgc aaatattcac ggaaatcaag ttctaggttt tcaaaataca gaaattgata
    15241 gtattttaaa agaagttgga aatgaattaa ttgatacagc cattatctat aaagatactt
    15301 gtacatggat gatacatgaa gtaacagata acgaaaaagt ttatataggt cctcttaatt
    15361 attccctata tgatggtgca ggattactta ttttcttact ggaattagct tcttatagtg
    15421 ataataagaa atatttacaa tatgctgaaa tgggccttaa aggattggtt actgatgtag
    15481 atctaagtaa aatagattct tactcaatct ttcatggact tggatcctac ctttatttat
    15541 atgcgagatt ttataatact acacaaaaat ctgagtacta caataaatta ctagatggtg
    15601 taaaaaattt aaatataaca tacaaaaaag atctaaacat agattttatt ggtgggttat
    15661 ctggaatgat agtatttcta acaaattgtt acagagcata tggggatgaa attttctata
    15721 aaaaagcaca tgagttcgct gaattaatga tttccattta taaagagaaa acagaattct
    15781 taaatggcct tgctcacggg cgtgctggca tttcattatc cttggcatca ttatatgaaa
    15841 taaataatga tgccaaaatt agtactgaag tttataaagt ccttaaacaa gaaaatcttc
    15901 attttaattc tactgataat aactggacag acttaagaga atttattaat actgaatcag
    15961 tatactggtg tcatggagcc ccaggcattt cattagctag aatgaaaaca atacaatacc
    16021 taggcataaa tgatttatta aacaaagatt taacatgtgg cattcgtaag acccttcaag
    16081 atggattttc tgattatcat gatagtagct tatgtcatgg agtatttggt aacttagata
    16141 ttttaataga aatcaacaaa tataaaaaat gcgaaacttt aagacatttt attgattcca
    16201 cattttctaa ttatatcgat aaccttacta agtttggata tcaatctggg ataaaaaact
    16261 ctttacctat taacaacttt atgctcggga aatttggaat cgcttatact ttactcagat
    16321 ataagaataa caaaatccca tgtatattat ctttagacat ttaagtaatt attatatgaa
    16381 gggaagatat cttgtgagca ttgaaattac taatctatca aaaagcttta ataaaagaga
    16441 aagagtctta gactctataa acatgaacat taaaaatggt gaaatagttg ggttagttgg
    16501 ccctaacggg gcagggaaaa ctacattaat gaaaatcatc tcagggctca ttgtacaata
    16561 tagtggtgaa attaagtttt ctcaagaaga atatactcaa ttaggtagct taattgaaaa
    16621 accaaaatat tttcctaata aaaatggtta ctataatttg aaatacttta gtgagctata
    16681 tagtgataaa gataataata ttgaagaaat tatacattct cttcaaatgg agaattattt
    16741 atctaaaaag gtaaaggatt attccttagg aatgaagcaa agactgggaa ttgctttagc
    16801 attgttaaac aatccaaatt atttaatatt agatgaacca actaatggaa tggatcctaa
    16861 tggtattaaa agtatcttaa aatatataaa aggggtaaca aagaaaaaaa atataggagt
    16921 tctcttatct agtcatattt tagatgatgt agcggatatt agcgatcggg tttatctaat
    16981 taacaagggg cagattatag atgaatattc tagctcaatt actcctgaaa agactattaa
    17041 atttactttt aatcaagaaa caattatcga ggcaactaag attttatcct atttcggatt
    17101 agtagaaaag acattaaata cagtttcatt gactaccgat aaagatttaa acatattgtt
    17161 agaaaagtta ggagaaaaaa gcatttatcc tcaaggtata aatgtaaaaa aagatacttt
    17221 agaagacttt tactttaaaa atataggagc tgagtaatat gaacttttca agctatatta
    17281 ggctggaact acttaggaat ataagtactg tataccttta tctagctatt attgcatctt
    17341 ttattttcgg ggggggaata gtctattcta tttattcctt agatggtcca tttcatgccc
    17401 ataatgtttc tggtctctac tcaaccatcg ctgttcttgc attagctata ttttgtgtaa
    17461 aaatcgtttc tatagattta tattatggaa ctatacaatt aatttttacg aataaacaga
    17521 atagacatct gttcctttat acaaggttaa tcattataac tgttatatca attctatttg
    17581 gcatcggatg tatatccttg ctctggataa atgatatatt aaatcatcaa ggattcaatt
    17641 tacaaatcgt ttgcaacaca ttattccatt attttttatt cgggattttt tacacacttt
    17701 tatttttatt aatttctatt ttctataaaa agcctatgaa tcttcttata attgcattct
    17761 ttacaattgt acttatacca agtatcctag gagcgatttt aaatattcct ggcctgtctt
    17821 ctatattaaa agaggcaatt atggcgttgc ccatatatag cttgcctaca aagatagcta
    17881 gcttatcgtt aagcataacc gatatatttg taattatcgg attgagtatt tgtttgtttg
    17941 tctggatatt ctatactctt cctaaaactg attattaaaa tttatccttt tcaatcaaat
    18001 cgcaactata aatgagggaa tttcatgaaa aaagtagtag cttacgttgc ttcaaggaat
    18061 aacagcagcc gtcctgttag aattacagaa aacttattaa ctgaactaaa aaggagtttg
    18121 aatcatcgaa ttaatacaac actcattaca cctctcacac ataatgtgct ccctccaacg
    18181 ggatgtaaaa gttgtttcaa tcaagggatt tgtccctctg attctttaac atatgacgat
    18241 actactttaa taaaaaatga gttattagaa gcagatctta tttttctagt tagtcctgtt
    18301 tattcacata atgtttctgg agacatgaaa aatctaattg acagaatctc ttattgggct
    18361 catattttta aattatctgg caaaccaatt atacttttgg cttctgcaga aagtaacggg
    18421 gcaaaatacg ttattaatta tatgaacaga gtatttactg ctatgggagc tacaataatt
    18481 gggcaagaaa cgtttttaaa tacagtggaa gattcataca aagggaaggt tgatattatt
    18541 ataaatctgt caaaaaaaat ccttttaaaa aatgttttct tatcccctac cgagcaacaa
    18601 gaaaatttgt ttcaatacct taaacaaact atttccactt acaataatga acatttcgaa
    18661 tataaatatt ggttacaaaa tggattattt aaaaagaata gtttagagga atactttata
    18721 gaacaacaaa aaaattaata ataaaatagc ccttttaggg ctattttatt attaattttt
    18781 tttatttttt tgagtatttt ccgaccacaa atcctgctgc ccccccaatt atagcagcta
    18841 agacactgga atataataat ccaaacacta cagcaagtcc taacgcaaat gcaaacgact
    18901 ctgaattcat taaaatcacc ttccgtattt taatttattt gaataaaata ttaaaataga
    18961 accaaattat ttaacaaagt taaaaacctc ttatttatta gtctaattct gaattacaaa
    19021 tttttcaagg ttgctttcaa aatattaatc tactaaaaaa ttgagttttg ctatcaggag
    19081 tgtagataat tatttttccc tctagtctaa aaaatgattt gaatttagta tatatagttc
    19141 agtattattt tactgatcaa agaaagtaag cataatcctc ctaaaatgga cagatttata
    19201 cttctctttt ttaaaatttc tcatcacccg aataatccac taagttgtca aaattccaat
    19261 taaactttgc ttctttatta tcgacattaa ttattccttc aagcattact ccacaagttg
    19321 ggcatccaaa agaaaaatga ttatttgata cataaccaac ctgaaacttt aataaatatg
    19381 atgtctcaca cactttacac attttttgtt taacatcgtt cattatctac actccttttg
    19441 aatcctaact agtttaccat aaattacatt atatgggatg tctaatttat tgtatgctct
    19501 cacatatcaa acctcgctaa atttataaaa gaattttcta tccacactgt atcaaaaggt
    19561 acaccttttg atatggttat cgctctatgt ttaaaggtgt atggagcatt tgataggtct
    19621 atagatgagg aattacaaaa ctattaataa aaactggata atattatact aaatacaaaa
    19681 aaacatactt ttagtatgtc tttttgtatt ttaatcagca ttttcggtat gcctacaaga
    19741 gggataacct gtgcaaccta tgaactgccc tttagaaagg ctatttgttt taataattaa
    19801 aactttagaa cacttggggc aagtcattcg tttatcttta agttggactt tcgcctctgt
    19861 agtatcaaag aataacaaat gttgtttaat atttttagaa ggttcgggtt gccatacgga
    19921 agtgatgtta aattttttac agtaatcata tatttcttta ccgaaccatc tacgggtttt
    19981 ctggaggttc aatttactaa cattacgtac tttatttctt cgccagtgat cgaagtatac
    20041 tctatcacct tttccttttt cgtcgtattt tgtatcattt gtttttgcgg ttcttgcgtt
    20101 tttgagtaat aaatcagtag gggcttcttt gaaaatattt aaagataagt ttaaaagatg
    20161 tttttgtaat tcttcaaaaa atgggtatgt tgtggaatca ccttttttat caattgtaca
    20221 aacgtaatct tttacttgtt gaaaaatatc tttaggaata taaatgttta cgttatcatt
    20281 ttcgttactt tcaagaaccc agctagcatt tgtattctta caagtaatta agatacttct
    20341 tggaataggt aaatagatac ctgtgaaaag accactatta tattcgaaat tgaaaagagc
    20401 actttgggaa gtatcatttt tacaaaattc atttaaatgt tgaaatactt tagtaaatat
    20461 cataagggta aatctcctct cattctcaaa gggttatata atgataatga aattttttct
    20521 gttactaaaa atagttaagg taaccctaaa ggttaccttt gtatcgtatc atatttattg
    20581 aagggttcca acaaaaaagt aaccataggg ttacttttat aaaaattcct attataatag
    20641 gtgtatgaaa aatttaaaat tatcaagaaa actattagga ttcacccaaa aatcccttgg
    20701 ggaagcactt ggtgtttcta atcaaatggt aaaaaattgg gaattgggtg taaaaaatcc
    20761 aagacttgag aatttgattt ctattgcaga catacttacg aaagaagccc gagaaattat
    20821 tgaaaaggag tggttggaag tacccaggga gaagattagt attgattatt tactcggcag
    20881 aagtatggat gaaggaactt cagtattact aactcgtatt tgggggctct cgacttatta
    20941 cagttacagg aatttgggaa ctgcaattta ttatttaccg gactctcctt caaataataa
    21001 tgaggaagta ttaaaccaag tattaaaaat aggtttgata gattctcctg atgaacttgt
    21061 tcagtacagc agaacgccac acttttacta tgacccatat tcaattggtg attatagcta
    21121 tggcggatca acccttgtag aaatcacaga tttattttgg gaaaatgaat aaagaataac
    21181 agttattccg ataattggag tagctgtttt tctttatttg atgtaattaa gtaattcata
    21241 atctttggca tcttgtgtga caaaattagt attgctattt taaatttaaa ttgggaatat
    21301 actcttatac ataatacgag gttaattaag aaaattgctt tttaaactag atggtcactt
    21361 aatacaataa acagcaacag aagttgttga gttagaaaat tcaatcttat gttttttctc
    21421 aatatgtctt ttcatatttt tgaattacaa tataattaat tctttttatt tctatatctg
    21481 tctcttatct tcctgttagg aatcctttat tgaattaagg attctttttt tatcctcatt
    21541 ttttgatcta atcgatattt tcccattgct tcatagatta aaaggtctaa tttttgacta
    21601 aaatcaatta cttttttatg gctaaatcca tattttttta caagatagct caattctttt
    21661 ttttgatctt caatcatgtc atgtagtaat ttcatatcca cctttttctt taaactcctt
    21721 tatacataaa atctcgaaaa aattgtatcc aaaaaattgc aaacaaaaaa caaggctgaa
    21781 accagccttg ccctaaagga aaaaaactaa ctcttatatc taagagtaca ttatgtatgg
    21841 gaatttttga agtggatata ccttaaaaag gataaaaagg ttataattgt aagattttga
    21901 aagttcgtta ttctataaag aaacagtcga aatcgcttat ttataaagga acatttgctt
    21961 tccattgctt aaaaccagta ccgaaaattt atcaacagcg ataattttcc caggtactct
    22021 gacaccgttt attagaaaaa tcgttacttc ttttttctct tctattaact tcgcataaaa
    22081 tttttcttgt gtatgcatca tttagatggt tgcaactcct ctcctttttc ggaacggttc
    22141 atagcttcta agaatacata ttcttttact gttagctcaa ccgttgggca atattcaacc
    22201 tttgataatt cgtgaaatag agaaaggttt ttgtgtagtt tttgaatcat ttcatctaaa
    22261 gtgatttctc ctacaccata ctcaattact gaatttaaaa atacgtctac atctattaaa
    22321 cttggttcaa ttagggaaac aatctcttgt acctttggta aaataattgt ttcataacgt
    22381 tgtttgaata gttctaaatc ctctggtgcg ggttcattct cacaaagctt tttgaaagat
    22441 agtacacgaa tgtcattttg taatgaatca atacgctctt cataaaaggc tttgtcgaac
    22501 ccttctttgt cagcaacatc gtaatgaagt tctgtttgtg atctaggctt tttcttataa
    22561 gcatccatga ggattttctc ttttgcatta aacatcatga taaaaacagt acgttctaga
    22621 ttcatgattt ggtttgctac gcttaatgtt tcatctaata cttttgcgcg ttcttcttca
    22681 cttaactttt ttatagagga tggaacaagt tttttgacat tctcaaacga ctcggaattc
    22741 ataatgtgtt gaagagaaaa ttgagcgact tctggtaaac aaggatcagt tgttttatcc
    22801 aggagtaaca aatctttaat cgttcgcact gtatttttga tctctttttg agcttgtcga
    22861 actttttcta tgcttctttc catgtattct ggttgtttaa gacggttgaa aatgtattct
    22921 cttctttctt caaaatgttg ctgtaaaagt gacatagttg tttcctcctc tattttctga
    22981 attgatttga aattcctttt atattgtatc attaaatttt atgaagtggg acggtagcaa
    23041 ggtttatttg caagacaagg tttgaaattg catatcagac aatcagtgat acatattctt
    23101 taccaaagca attaccaaag tagatatcaa ccttataacc aaagaaacta ttatggtatc
    23161 actatcaaaa gaactcctcg attagcacat gtttttaggg gattttgagt tttgtttata
    23221 gtaggcggaa cggaataaga aaaaggaggg agaacaatga ataattctta tgagattatt
    23281 gataatcaaa tattatttga gggatgatcc ggcaagaggc tggaacaaca tacttggtcc
    23341 gcaatttcaa agtgtgaaag aaattacaga atgatgtggt cgttcaacaa acgaaagtat
    23401 ttgtgagtag gatgcgttta atcaaaatgc aataagtaca acggatataa cagatttctt
    23461 atatagatgg attagttggt atgtgacaga accattagac agtacaagaa atacgaaagt
    23521 taccagatga acttacgagt tttataacaa atgtacttgt tgagacattt gaatgcatta
    23581 agaatacctc tcatatggtg ttagattgta tatgctttgt attggactgg acccccaatt
    23641 tgttaacgat attctttttt taggagggaa aacatgctga atcgaaaaga aacaatttct
    23701 tttcaagcct ttatggacca atcttataag aagaaaaagc caacaaaaat atatagtatt
    23761 ggccctatta gtccgttcgc attttttcat atgtcttcac cgctttttca tacgtatgta
    23821 gctctgggaa tagtaggcgg ccttacaatt ggagctgttt tgttggaaaa gtacttagta
    23881 cgaaatgatt atatttttgc atccaatctc ctttctaatg gtctgtatta cggtgtaaga
    23941 attggaggaa ttgggttcat tggttatgca tttattcgta ttttactcat gttataggga
    24001 gggttaccaa tgaaaggatg gttaaaaaag aaaaaatata aatatcaatt agaagaagta
    24061 tttaagaaag cgaagctata cgatgagcac attacacgag ggggaaaggt ccccatttat
    24121 cctaagattc atgatgtttt cgaagagaat gaaagtgtac ggtacacctt tacattgcca
    24181 aacggcgttg atccagctca aattcataag aaatggtttt gttttcagca aatactaggt
    24241 gaaaatctta tgatggaagg tactattaaa aggttcgtac tccatgtatt tcattctgat
    24301 gcaaggttac agccttacaa ttacagctat aaacaatggc aaccattatt gaaacaatat
    24361 cgtcttcctg tggtagtagg gcgggaccaa ttcggaaatg caattgtgta tgatatggtt
    24421 gattcaaata cacctcattt actgattgca ggagaaacag gaagcggaaa aagtagtatg
    24481 gtgcgcgtaa ttttagctac attaatccaa catatgtcac cagatcattt acatttgtac
    24541 ctgggggact tgaaaaattc agagtttcat tttttaagaa gagtgaagca cgtgaagtat
    24601 gtttgcatgg aagaacacga aatgacaagt atgttatcaa aattatggaa agaggtattg
    24661 cataggagaa aggtaatgga agaatatgag ctgggtcata ttgatgaata caatcaaata
    24721 acaaaagata aacccttacc atatattttt attgccattg atgaagtagc aatgctacaa
    24781 gacgaaaagg aatgtgtcac cataatagaa aaaatatcag ctgtcggcag atcacttggt
    24841 atcttcctca tgctaagtat gcaacgtcct gatgcaaaaa tacttgatgg taagttaaag
    24901 ctcaatttga cggtaagaat gggctttaaa tgtgcggatt taattaacag taacattgtg
    24961 gggacgcctg gatcagaaaa tttaagtcaa tcgggtcaaa tgattttaaa attagatggt
    25021 ttaaagaagg tgcaggctcc ttatttggca ttggaccagg cgaaagaaat aatagaaccg
    25081 tatcgtttat ctaaagagca aagtataaag aaggaagaac cagaacatca agaagacaaa
    25141 atctttgggg tgttagatga tgctaacgaa tagagataag caaattatcg gtcatttaca
    25201 gcaatttcga tgtatgtcgc gtgatgatat tattgatctc cattttagaa atgtaaaaaa
    25261 tgcagtaaca tgctgtaata ctgttacaaa gcggttaagc cgcgaaggat atatcgatgt
    25321 agatacatca caacgtccat acgtgtattt tccttatcca aataccattc gtaaaggaag
    25381 ccaaaagata cgtcattttt tagcgattgt agatgtatat aagcagttat tacgaaccga
    25441 aagaccgaag atatttcaag tagaacctaa gtataagaaa ggttatatgg aacccgacat
    25501 atttaccatt tggcgtaaaa gtccattttt tatagaagtt cagaactcca tttataataa
    25561 ggctacgatc caaacgaaaa taaaacgtta tgaatcgtat tttcgtagca tggaatggaa
    25621 aaaagaatcc tggcaaccga aacataatat ggtatttccc tcacttttaa tccttactga
    25681 cctcaaatat ccaatctcta gttctaattt ccgtattttt caagcgccct ctattcagca
    25741 ttttcttaca caagtacagc aacctaaaga catttcgatt caaataggtt cagtcaaagc
    25801 aaaattatga aagcacaaga tactgtttct tgtgcttttt acatgtccca aaagtcattg
    25861 attttggcgt gagggtcaat ttttctaata gtatttaata tttttttcat gatttcaggt
    25921 ttggggatgt aatctgtatc tctacatgct ttactgatgg tttgaacaga aacctttgac
    25981 tttttggcta gttcctgttg ttcaattcct tgccgatcta accatttttt taatttagtc
    26041 ctatttttgc ggaaaaacat ttatctcact ctcctgtcct taatttttta tttacaatta
    26101 tggacaggaa gttaaattca tatacaattc acttcaactt aaacttaagt aaaatacaag
    26161 agaacgagat tcatagagta tttacacgaa cgatttattg ataatttcac ttggaatgag
    26221 gtatacatac aatgcaaaga tttgacttac gcatcataca acaaatcttt gcaaagcact
    26281 ttccaaaaga atccaactta atctgtatct aaagaacaca aaaaaagact gttttgtttt
    26341 atttgtataa gatatgtgat tgga
//
