LOCUS       NZ_CP036071            10347 bp    DNA     linear   CON 25-JUN-2024
DEFINITION  Bacillus wiedmannii strain JAS07/5 plasmid p79.
ACCESSION   NZ_CP036071
VERSION     NZ_CP036071.1
KEYWORDS    RefSeq.
SOURCE      Bacillus wiedmannii
  ORGANISM  Bacillus wiedmannii
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 79335)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 79335)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.157x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018741285.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 04:17:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,980
            CDSs (total)                      :: 5,827
            Genes (coding)                    :: 5,631
            CDSs (with protein)               :: 5,631
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 88 of 196
            Pseudo Genes (incomplete)         :: 110 of 196
            Pseudo Genes (internal stop)      :: 59 of 196
            Pseudo Genes (multiple problems)  :: 52 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 10347
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036071.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10347
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     gene            <1..1194
                     /locus_tag="EXW41_RS26785"
                     /old_locus_tag="EXW41_27155"
     CDS             <1..1194
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000222805.1"
                     /locus_tag="EXW41_RS26785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27155"
                     /product="replication initiation protein"
                     /protein_id="WP_088064996.1"
                     /transl_table=11
                     /translation="MSLKQDLQIKENNIVSKSNTLIEANSRLNLVEQKMLLCLASNIEP
                     SDRDFKTYTFPIKQFHDLLGLSGSTKYTELSKITKELVSKVIEIRIGEELIQVSWLSSA
                     IYNKNKGTIDLRFDPLLKPFLLELSSKFTSYRLANVVKLKSTYAIRIYELLKQYENIKE
                     RTISLENLRYYLDAIDVYPNYANFKQRVLKPSQKELNQKTDISFEFEEIKLGRKVQKIR
                     FIIRSQKRKDTDLAHFEKKLDEFQQPNTFEQKIKRFEERYKGKVYPAVLEKWKKHEELV
                     LEIIDDIRFRIDIDSPMGYVEYMLNSRLKELSDTAILKQDIQENFSLKMDNIIDAVIAK
                     YSKSTGAVATFLVKDTAINELIRICTLEEAEEYWKEKEEFVMDSIYEYIKKNRRKKR"
     cand_cluster    1..10347
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10347
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3130:5347](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3131..5347
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(1422..1547)
                     /locus_tag="EXW41_RS29995"
     CDS             complement(1422..1547)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS29995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_255298929.1"
                     /transl_table=11
                     /translation="MNTEELQDLTFEELEKIDIGHMQWAHDLGYWLENKTAGLFK"
     gene            1720..1947
                     /locus_tag="EXW41_RS26795"
                     /old_locus_tag="EXW41_27160"
     CDS             1720..1947
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018783147.1"
                     /locus_tag="EXW41_RS26795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27160"
                     /product="DUF3937 family protein"
                     /protein_id="WP_064474325.1"
                     /transl_table=11
                     /translation="MVEKKRVIQIGLWLYIFLVCIQFLIHYIKGYKLSQNGVGISNVLN
                     VTWENILLDIPQSILVIIGCLVLFQFTKGK"
     gene            2026..2493
                     /locus_tag="EXW41_RS26800"
                     /old_locus_tag="EXW41_27165"
     CDS             2026..2493
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS26800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW41_27165"
                     /product="hypothetical protein"
                     /protein_id="WP_215559088.1"
                     /transl_table=11
                     /translation="MVLLKKKILEFIRCFKNNECTLKPLAGEKVPAFKELSKFKRKTRF
                     KNTTAKYALLIFIKNSDLMSNQELLLNLPHISIDFNIKIMVISDGAFNPHVSEEVQYIK
                     SKYLFYKYFVEHQPKMFLVDAKGFLVFEMSGTSSYLLKKVLEDYFLDSCKL"
     gene            complement(2577..2771)
                     /locus_tag="EXW41_RS26805"
                     /old_locus_tag="EXW41_27170"
     CDS             complement(2577..2771)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS26805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW41_27170"
                     /product="hypothetical protein"
                     /protein_id="WP_064474323.1"
                     /transl_table=11
                     /translation="MNNTLNKFEELNEAELELNGGWGEEALGDLVGWITSESNKNKNKY
                     CGQYKNVNDRNNCYYLWEN"
     misc_feature    complement(3036..3051)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 24.31"
                     /tool="antismash"
     gene            3131..5347
                     /locus_tag="EXW41_RS26810"
                     /old_locus_tag="EXW41_27175"
     CDS             3131..5347
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000473021.1"
                     /locus_tag="EXW41_RS26810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27175"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_088065040.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.8e-41, bitscore:
                     133.6, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 5.5e-206, bitscore:
                     678.6, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKTFKCIKQHDLKDCGPACLSMISHHYGLNMSISKIREIAGTD
                     LQGTNIKGLLEASERLGFNTKGVKAKNPEAINEIPLPAIAHVVDHGLLHYVVIYKVKNG
                     KVYVADPAKGHRVFELKQFCEIWQGILILLTPGNNFEKGDVSQGTFSRFLSLLKQQTHL
                     LLPLFFVSIFFNFFGLIGTFYFKFLIDDIVTNQLLQSLHIVSIGIIILYIFQVVISYFR
                     THLILYLSRRMDIQLMLGYYHHVVGLPMKFFETRKVGEIISRFMDASKIREALSTITVT
                     LMIDTVMVMVGAILLYMHSAILFGVTLLLIPFYIGIIFAFHKSYQTINREEMESNAKLT
                     SYLVESLNGIATVKSFNAERQVFFETESRFVSLLKRIFKRGMLSNLQGSIKMGLELIGG
                     TVILWVGAVQVLKGNMTIGELITYNALLAYFLKPIENLIGIQPTMQSALVAGERLNEIL
                     DLDPEKNETEYKKIKPKQLSGKIDFSNVTFRYGTRKDVLKDINFSIEQGDQVAFVGESG
                     SGKTTISKLLMHYYEPNQGDIYYDDYHIKEINRTSLRDRIAYVSQESFFFSGSIYDNLR
                     FGLDNQVTLDEIINVCKKAYAHNFISDLPLRYETLLEENASNLSGGQRQRLAIARALLK
                     KPDILILDEATSNLDSTTEKYITDMLKELRNLGVTVIMIAHRLSTIQHANQIFVMEKGN
                     IIERGSHEELLFSKGEYYRLWKNQTVHVEHIELEQFAMRGEQYE"
     gene            5340..6647
                     /locus_tag="EXW41_RS26815"
                     /old_locus_tag="EXW41_27180"
     CDS             5340..6647
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1029: RND family
                     efflux transporter MFP subunit"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000036963.1"
                     /locus_tag="EXW41_RS26815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27180"
                     /product="HlyD family efflux transporter periplasmic
                     adaptor subunit"
                     /protein_id="WP_064474322.1"
                     /transl_table=11
                     /translation="MSKFYSFDELTDSVELLEKKPPRFIMGLLYFLLIGLLGFLMWAYF
                     GKIDIVSKGPAFVQGNSEVSVSRSQVPGIIEKIAVHSGDEVKKGDVLLQLQNKELTEKN
                     NQSNEIVKHLESQKNMLEQLKQSILRNKNVFSNEVDPKISEEYNAYQQGYQVLQNEKDI
                     EIKSLDSDKVVDNQDDALLGLNAEKENIQREIKNLKHETEKPNVPNEQKQVVDEKIKSL
                     EAQFTSLEKRAEQRKVTLEEQRKKMDTILEGKKEQKQYALKQYQENTVAAVNQRIFSLE
                     QEIFLKNQEVSGLRNQMENVVIKAQRDGIVQFPSVLQNGDLIESGQEIVSVIPKETQKK
                     VHILLPPQEINGIKKGDKVQYSFKLKDTDKQMGKVTYISAHPTFDKDSKSYMYALEATI
                     DTKELNELKVGIIGRAAVVTGKEPIWKFILQKLDFI"
     gene            6757..7428
                     /locus_tag="EXW41_RS26820"
                     /old_locus_tag="EXW41_27185"
     CDS             6757..7428
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000760091.1"
                     /locus_tag="EXW41_RS26820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27185"
                     /product="autotransporter"
                     /protein_id="WP_215559089.1"
                     /transl_table=11
                     /translation="MKKHIFIALFFILFGVFSPFSNMYAETNNISKNDQIVNVFNNSNL
                     EEKINYIKSSNLNNWSVAEINQTLDRLDKLNLDIMERATLKREIIRQAGFSNFDFKGTN
                     SDVFAFKELRIDIIETEEPIVLYRRSKAGEPESKYGLGYWWGDKERNIEETRNELAVLE
                     AWGNPLSTAYKIQVPKGTKILKGITASQIQYLNGSKVVQEYREGGAVQYWINTVSNSWL
                     K"
     gene            7449..7721
                     /locus_tag="EXW41_RS26825"
                     /old_locus_tag="EXW41_27190"
     CDS             7449..7721
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002129808.1"
                     /locus_tag="EXW41_RS26825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27190"
                     /product="hypothetical protein"
                     /protein_id="WP_088064994.1"
                     /transl_table=11
                     /translation="MNKDHEFINLTLNCEYIIKQNIPSNPDDTHRYHLMLKELTGLRMT
                     TKLNQLNTKMHYLSITQMLEKNDPEEVLQAVVTLNKFYCTYYQNV"
     gene            8040..9242
                     /locus_tag="EXW41_RS26830"
                     /old_locus_tag="EXW41_27195"
     CDS             8040..9242
                     /GO_function="GO:0003887 - DNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006270 - DNA replication initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018783730.1"
                     /locus_tag="EXW41_RS26830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_27195"
                     /product="replication initiation protein"
                     /protein_id="WP_088064993.1"
                     /transl_table=11
                     /translation="MTVKQDVQIKESNIVSKSNNLIEANSRLNLVEQKMLLCLASNIEP
                     SDQDFKTYTFPIKQFHDLLGLSGSTKYTELSKITKELLSKVIEIRIREKLIQVSWISSA
                     IYNRNMGTIDLRFDPLLKPFLLELSNKFTSYRLANVIKLKSTYAIRIYELLKQYEHIKK
                     RTISLENLRYYLDAIDVYPNYANFKQRVLNPSQKELNQKTDISFEFEEVKLGRKVQKIR
                     FIIHSQKRKGTDSEHFEKNSDNFKQPNTFEQKIKRFEERCKGKVHPAVLEKWKKHEELV
                     LEIIDDISFRVDIDSPIGYVEYMLSSRLKEQSDNEILIQNNQENLFNNTLEIDKIINAI
                     INKYSASTGAVATFLVKDTAIKELVKICTLVEAEECWNKNEEFVMNKIYERIKRNRRIR
                     R"
ORIGIN
        1 atgtctctaa aacaagattt gcagattaaa gagaataata ttgtttcgaa atctaatact
       61 ttaattgaag caaattcacg tttaaattta gtagaacaaa agatgctgct ttgcttggca
      121 agtaatattg aaccaagtga tcgggatttt aaaacatata catttccaat taaacaattt
      181 catgatttac ttggcctaag tgggtcaacg aaatatactg agctaagtaa aattacaaag
      241 gaattagtgt ctaaagtaat tgaaattagg ataggagaag agttaattca agtatcttgg
      301 ctttcttcag caatttataa taaaaataaa gggacaattg atctgcgttt tgatccatta
      361 ttgaagccat tcttattaga attaagtagt aaatttacaa gttatagatt ggctaacgtt
      421 gttaaattaa aaagtacata cgctatccga atttatgagt tattaaaaca atatgaaaat
      481 attaaagagc ggacaattag tcttgaaaat ctaagatact acttagatgc tattgatgta
      541 tatcctaatt atgctaattt taaacaacgt gtactgaaac cttcccaaaa agagttaaat
      601 caaaaaacag atatatcttt tgaatttgaa gaaattaagt taggtaggaa agtacaaaaa
      661 attagattta ttatacgtag tcaaaaaaga aaggatactg atttagctca ttttgaaaaa
      721 aaattagatg aatttcagca gccaaataca tttgaacaga aaattaaacg ttttgaagaa
      781 cgatataaag ggaaagtata ccctgcagta ttagaaaaat ggaaaaaaca tgaggaattg
      841 gttttagaaa ttattgatga tatccgcttc cgtatagata tagattcgcc aatgggttat
      901 gtagaatata tgcttaattc tcgactaaaa gaactatccg acaccgcaat tttaaaacaa
      961 gatattcaag aaaatttttc attgaaaatg gataatatta tagatgcagt aatagccaaa
     1021 tactcaaaat ctacaggtgc tgtagctaca ttcttagtca aagataccgc tattaatgaa
     1081 ttaataagaa tttgtacatt agaggaagcg gaagagtact ggaaggaaaa agaagagttt
     1141 gttatggata gtatttatga atatataaaa aagaatagaa gaaaaaaaag gtaggctagt
     1201 tttgaactat ccccactttc acgtcgttta gaagagggga atttctaagt aaagagttct
     1261 ataggctatc tccacagtcc ctgcgtttaa aagccttatc gcttcatgtt ttagattgat
     1321 acttgcgtta atatccctat catgatgtgt catagaaatt atgaaaacat ccaatgattt
     1381 tctctaatac ctttagagag gggcattgga tgtttttaat attatttaaa aagtccagca
     1441 gttttatttt caagccaata ccctagatca tgagcccact gcatgtgccc aatatcgatt
     1501 ttttctagtt cttcaaacgt taaatcttgt aattcttcag tattcataag aaagtcctcc
     1561 ttaataataa cggacgtata atatattaat atataaatta aaatttagat taattaaatt
     1621 gattggaagg ttattggata ttaatttgat attttgttat attaatctag gtcatataaa
     1681 tttatctatt atactatcaa aataatcagg agggaaaaca tggttgagaa aaagagagtt
     1741 attcaaatag gcttatggct atatatcttt ttggtatgta ttcagttctt aatacattac
     1801 attaaaggtt ataagcttag tcaaaatggt gtagggatat ctaatgtgtt aaatgtaacg
     1861 tgggaaaata ttttacttga tatcccacaa tctattttag taattatagg atgtttagta
     1921 ttgtttcaat ttacaaaagg gaaatgaata attaagactt tttaaatttc attaaatatt
     1981 ttatagccaa ttacactatt ttactagaaa tgtggttcat aaaaaatggt tttattaaaa
     2041 aagaaaatct tggaattcat taggtgtttt aaaaataatg aatgcaccct aaaaccttta
     2101 gctggtgaaa aagttccagc ttttaaagaa ttgagtaaat ttaaaagaaa aactagattc
     2161 aaaaatacta ctgcaaaata tgcgctttta atttttatta agaatagcga tttaatgtct
     2221 aatcaagaat tattattaaa tttgcctcat atttctattg attttaatat aaagattatg
     2281 gttataagtg atggagcttt taatccgcat gtttctgaag aagtgcagta tattaaatca
     2341 aaatatttat tttataaata ttttgtagaa catcaaccta aaatgttttt ggttgatgct
     2401 aaagggttcc ttgtttttga aatgagtgga acatcttcgt atttactgaa aaaagttttg
     2461 gaggattatt ttttagatag ctgtaaatta tagtaattgt atactatcca accaaataca
     2521 gtattttaca aatataaaaa ggatggcata atgaccatcc tttttatatc aatactttag
     2581 ttttcccaaa ggtaataaca attattacga tcgtttacgt ttttatattg accacaatat
     2641 ttattcttgt ttttattaga ttcacttgtg atccatccaa ctaaatcacc aagtgcttct
     2701 tcaccccagc caccatttaa ttcaagctca gcttcgttta attcttcgaa tttatttaat
     2761 gtgttgttca ttttattttc ctcctaacta atttttattc ccagtaagct ttaccttctt
     2821 gagatctttg ataacctttg aaatatcctt tgaaaaattt aacccaaggc atttattttc
     2881 ctccttccga ttacaattta aaaatcttta tagttaatta tcgcgatgtt taacatggta
     2941 ttattataca ataaaagtaa ggtttgtcca taataaattt tatttttttc taaaaatgtt
     3001 aaatttaaaa aaaaatacaa aaaaatttat ttttagttta taattgtaaa aaacttttgg
     3061 tattgttttt ttatttataa ttaaatatat agaaatttta atttacattt tttagggagt
     3121 aggtagtgtg ttgatacgga agacattcaa gtgtattaag caacatgatt taaaggattg
     3181 tggtccagca tgtttatcga tgatttcaca tcattatggt cttaacatgt caatttcaaa
     3241 aatccgtgaa atagctggta cggatctaca aggaacaaat ataaaaggct tattagaagc
     3301 ttctgaaagg ctaggattta atactaaagg tgtaaaagca aaaaatccag aagcgataaa
     3361 tgaaatacca ttgcctgcta tcgcacatgt tgttgatcat ggtttattac attatgtggt
     3421 gatttataaa gtgaaaaatg ggaaagtata tgttgccgat cctgctaagg gtcaccgtgt
     3481 atttgaatta aaacagttct gtgaaatttg gcagggcatt ttaatattac ttacacctgg
     3541 aaataacttt gagaaagggg atgtctctca aggaacattt tcgcggtttt tatcgctatt
     3601 aaagcaacaa acgcatttgt tgttaccatt attttttgtc tcaatctttt ttaatttctt
     3661 tggattaata ggaacctttt attttaaatt tttaattgat gatattgtaa cgaatcaatt
     3721 gctgcaatca cttcatatag tttctatagg aattattatt ttgtatattt ttcaagtagt
     3781 aatttcttac ttcagaacac acttaatttt atatttaagt cgaagaatgg atattcaatt
     3841 aatgctcgga tactatcatc atgtggtagg attacctatg aagttttttg aaactagaaa
     3901 agtaggagaa attatttcac gctttatgga cgcaagtaaa atcagagaag ctttatccac
     3961 tataacagta acattaatga ttgatactgt tatggttatg gtaggggcta ttttattgta
     4021 tatgcatagt gcaattttat ttggagtaac acttttacta attccatttt atattggaat
     4081 tatttttgct ttccataagt catatcaaac tattaataga gaagaaatgg agagtaatgc
     4141 caaattaaca tcctacttag tagagtcgtt aaacgggatt gcaacagtaa aatcattcaa
     4201 tgcggagaga caagtgtttt ttgaaacaga aagtcgcttt gttagtttat taaaacgtat
     4261 atttaaaaga ggaatgctat cgaatttaca gggttctatc aagatggggc ttgaattaat
     4321 tggaggaact gtaatccttt gggtcggtgc tgttcaagta ttaaaaggaa atatgacaat
     4381 tggtgaatta attacatata atgcactttt agcttacttc ttaaaaccta ttgaaaattt
     4441 aataggcatt cagcctacta tgcaatccgc attagtagct ggggaaaggt taaatgaaat
     4501 attagattta gatccagaaa aaaatgaaac agagtataaa aaaattaaac ctaaacaatt
     4561 atcaggaaaa atagattttt ccaatgtcac gttccgttat ggaacacgta aagatgtttt
     4621 gaaagatatt aatttttcaa ttgaacaagg cgatcaagtc gcttttgttg gagaaagtgg
     4681 ttcaggaaaa acaactattt caaagttatt aatgcattat tatgagccaa atcaaggaga
     4741 tatatactac gatgattatc atattaagga gataaatcgt acttcattga gagatcgaat
     4801 tgcttatgtt tcacaagaat cattcttctt tagtggatct atttatgata atttgcgctt
     4861 tggattagat aatcaagtta cattggatga gattattaac gtatgcaaaa aagcatatgc
     4921 acataatttt attagtgatt taccattacg ctatgagacg cttttggaag aaaatgcttc
     4981 gaatttatct ggtggacaaa ggcaaaggct agctattgca agagctttat tgaaaaaacc
     5041 ggatatattg attttagatg aagcaacaag taatttagat tctacgacag aaaaatatat
     5101 tacagatatg ctgaaagaat taaggaattt aggagtaaca gtaattatga ttgcccatag
     5161 attaagtaca atccaacacg caaatcagat ttttgtaatg gaaaaaggaa acatcattga
     5221 acgtggttct catgaagaat tattattttc taaaggtgag tattatcgtc tgtggaaaaa
     5281 tcaaactgtt catgtagaac atattgaatt agaacagttt gcaatgcgag gtgagcaata
     5341 tgagtaaatt ttattcattt gatgaattaa cagatagtgt agagttgtta gaaaaaaagc
     5401 cacctcgctt tattatggga ttactatatt ttctcttgat aggtctgtta ggatttttaa
     5461 tgtgggctta ttttgggaag atagatattg tgagtaaagg gccggcattc gtgcaaggaa
     5521 attcagaagt aagtgtatcc cgttctcaag ttccaggaat tatagagaaa attgctgttc
     5581 attctggtga tgaagttaaa aaaggcgatg ttttacttca attacaaaat aaagaattaa
     5641 cggaaaaaaa caatcaatct aatgaaattg ttaaacattt agaatctcaa aaaaatatgt
     5701 tagaacaact gaaacagagt attttaagaa acaaaaatgt attttcaaat gaagttgatc
     5761 caaaaataag cgaagagtat aacgcctatc aacaggggta tcaagtttta cagaatgaaa
     5821 aggatataga aataaaatct ttagatagcg ataaagtagt cgacaatcaa gatgatgcat
     5881 tactaggttt aaatgctgaa aaggaaaata tacaaagaga aattaaaaat ttaaaacatg
     5941 aaacagaaaa accaaatgta ccaaatgaac aaaaacaagt tgtggatgaa aagataaaat
     6001 cgttagaagc tcagtttact agtctagaaa aaagagcgga gcaaagaaaa gtaactttag
     6061 aagaacagag aaagaaaatg gacacaatat tagaaggaaa aaaggaacaa aagcaatacg
     6121 ctctaaaaca gtatcaagaa aatacagttg ctgcggttaa tcaacgcata ttttctttag
     6181 aacaagaaat tttcttgaaa aatcaagaag taagtgggtt acgtaatcaa atggagaatg
     6241 tagttataaa agctcaacga gatggtattg ttcaatttcc ttccgtgtta caaaatggag
     6301 atttaattga atccggacaa gagatagttt ctgttattcc aaaagaaact cagaaaaaag
     6361 ttcatatatt gttaccgccc caagagataa atgggataaa aaagggagat aaggtacagt
     6421 attctttcaa attaaaagat actgataaac aaatgggtaa agtgacatat atatctgcac
     6481 atcccacttt tgataaagat tctaaatctt acatgtatgc attagaagcg actattgaca
     6541 caaaggaact taatgaatta aaagtgggca taataggtag agctgctgta gtaactggaa
     6601 aagaaccgat ttggaaattt atattgcaaa agttagattt catctaaaat taaatagaaa
     6661 aatatattta taaaaaacac tttccttaaa aatatattgg gtttgtatta tttataagtg
     6721 atcaaaatat tatagtatag gagaatataa ctagttatga aaaaacacat ttttattgca
     6781 ctatttttta ttttatttgg ggtgttttcc ccgttttcta atatgtatgc ggagacaaat
     6841 aatataagta agaatgatca aattgttaat gtttttaata atagtaattt agaagaaaaa
     6901 attaactata ttaagagtag taatttaaat aattggtctg ttgcggagat taatcaaacc
     6961 ttagatagac tagataaatt aaacttagac ataatggaac gtgcaacatt aaagagagaa
     7021 ataattcgtc aggcaggttt ttcaaacttt gattttaaag gaacaaattc agatgttttt
     7081 gcatttaaag aattgaggat agatattatt gagactgagg aaccaattgt attatataga
     7141 cgaagcaaag ctggcgaacc agagtctaag tatggtcttg gatattggtg gggggataaa
     7201 gaaagaaata ttgaagagac tagaaatgag ttagctgtat tagaggcatg gggaaatcca
     7261 cttagtacag catataaaat ccaggtgcca aaaggtacta aaatacttaa aggcatcaca
     7321 gcttctcaaa ttcaatatct aaatggatca aaagtcgtcc aagaatatag agaaggtggg
     7381 gccgtgcagt attggattaa tacagtaagc aatagttggt taaaataaaa tatttctagg
     7441 agggaatcat gaacaaagat catgagttta taaatttgac tctaaattgt gagtacatta
     7501 taaaacaaaa tattcctagt aaccctgatg atacccatag atatcattta atgttaaaag
     7561 agcttacagg tttgagaatg actactaaat taaaccagtt aaatactaaa atgcattact
     7621 tatcaataac gcaaatgcta gagaaaaatg acccggaaga agtgttacaa gcggttgtaa
     7681 cacttaataa gttctattgt acttattatc agaatgtata gaggaacctg aatcattctt
     7741 agacataact atgtaattaa gattcaatac tataaacata ttttagttat tttctacaaa
     7801 ttaaatttaa atcgtttcta aattaataaa tataaacaag caaacataat attctacgtt
     7861 tgcttgttat atatatatta attttgcaaa agcatctaat atagctaaag ttagaaaaca
     7921 gcattataac aaaaatggtt gttcaattat aacgaaaata gttctgaaaa ccgaactata
     7981 aaagtatttg atatagttat tggattaata aagagcgtaa ggaaaggcct tgtgtagata
     8041 tgactgtaaa gcaagatgta cagattaaag agagtaacat tgtttcaaag tctaacaatt
     8101 taatagaagc aaattcacgt ttaaatttag tagaacaaaa gatgctgctt tgcttggcaa
     8161 gtaatattga accaagtgat caggatttta aaacttatac atttccaatt aaacaatttc
     8221 atgatttact tggtttgagt ggatcaacga aatatactga gttaagtaaa attacaaagg
     8281 aattattatc caaagtaatt gaaattagga taagagaaaa attaatccaa gtatcatgga
     8341 tttcttcagc aatttataat agaaatatgg gcacaattga tctgcgcttt gacccattat
     8401 taaaaccatt tttattagaa ttaagtaaca aatttacaag ttatagatta gccaatgtta
     8461 ttaaattgaa aagtacatac gctatccgta tctatgagtt gttaaaacaa tatgaacata
     8521 taaaaaaacg gacaattagt cttgaaaatt taagatatta cttagatgca attgatgtat
     8581 accctaacta tgctaacttt aaacagcggg tgttaaatcc ttctcaaaaa gagttaaatc
     8641 aaaaaacaga tatatccttt gaatttgaag aagttaagtt aggtaggaaa gtacaaaaaa
     8701 ttagatttat tatacatagt caaaaaagaa aaggtacaga ttcagaacat tttgaaaaaa
     8761 attcagataa ttttaagcag ccaaacacat ttgagcagaa aattaaacgt tttgaagagc
     8821 gatgtaaagg gaaagtacat ccggcagtat tagaaaagtg gaaaaaacat gaggagctgg
     8881 tattagaaat tattgatgat atcagcttcc gtgtagatat agattcaccg attggttatg
     8941 tagaatatat gcttagttct cgattaaaag aacaatcgga caatgagata ttaatacaaa
     9001 ataaccaaga aaatctattt aataatacat tagaaatcga taaaattata aatgcaataa
     9061 taaataagta ctcagcgtct acaggggctg tagcgacatt tctagttaaa gatactgcta
     9121 ttaaggaatt agtaaaaatt tgtacattag tggaagcgga agagtgttgg aataagaatg
     9181 aagaatttgt tatgaataaa atttatgaaa ggataaaaag gaatagaaga ataagaagat
     9241 gacatacttg tttttgaaaa tttttaaaag taagttaaac ttgtagatta ttctccacgt
     9301 acatttatca agctaatagg ttagtacctc tttctacaac aaccctatat ttacagtttt
     9361 catggagcaa tctgtacaag tagatagtag caagcatttt agcttatctc aactgaattt
     9421 catcgctcac ctatttatcg gtgctatcaa gccttcaagc aaatcgaggt gggagttttc
     9481 tgtcggaaaa tgataaaaaa tcatcctatt tggatgattt ttttatttgt tatataaaat
     9541 ttagctaata aatgtgagat ataacaaaaa tatcgtcatc tcatcgtccg gttatctaga
     9601 caactggatg atgagatttg attaaacatc aataaatttt gaggacatgg gtcaatttca
     9661 aatattggct tgttaggggt gggaatgtac ctttaaagaa atttgaataa ttttttattg
     9721 ttctctattg aactattagc acttaacatc cttagggaaa ttttgaagtg ggagtttggt
     9781 gcgatcactg atttaaccag aatctgcccg tggtccctat actgaaaact gaggtatctt
     9841 atacgttgac tcaacacgtc cttttacttt atcctgattt tcgcaatttc agtaaacgtg
     9901 ggacgataga gcgttgaaga tttcacggtg gcaacaattg ttctgcaacc aaccgtatac
     9961 cctcagtttt cagaaagcaa tctgcgcaag taggtattag taaacatttt ggcttacgtc
    10021 aaccgccatt cgtctcttcc gtatttgttg atactatcac actttcacac taattgaggg
    10081 gggccttctg ccggaaaaga gaacaagatt ataactgtgc taatgacttc tcatattctt
    10141 tgagtatttt ataaaatgta tttttcttta gttctaatag tttcataaat tcaaccccac
    10201 taatttcttt atttttccac tttggataaa tgtcttttat tataagtagt tgtttagagt
    10261 ttaatgttga gagattaaat tgaggacgtc ctaaatgttt ccctttaaat ttagccaaag
    10321 taattccttc tgcttgacgt tgacgaa
//
