LOCUS       NZ_CP036070            25238 bp    DNA     circular CON 25-JUN-2024
DEFINITION  Bacillus wiedmannii strain JAS07/5 chromosome, complete genome.
ACCESSION   NZ_CP036070
VERSION     NZ_CP036070.1
KEYWORDS    RefSeq.
SOURCE      Bacillus wiedmannii
  ORGANISM  Bacillus wiedmannii
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5239489)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5239489)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.157x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018741285.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 04:17:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,980
            CDSs (total)                      :: 5,827
            Genes (coding)                    :: 5,631
            CDSs (with protein)               :: 5,631
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 88 of 196
            Pseudo Genes (incomplete)         :: 110 of 196
            Pseudo Genes (internal stop)      :: 59 of 196
            Pseudo Genes (multiple problems)  :: 52 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2426829
            Orig. end                         :: 2452067
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036070.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25238
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="5"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25238
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25238
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15238](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15238
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            <1033..1296
                     /locus_tag="EXW41_RS12245"
                     /old_locus_tag="EXW41_12345"
                     /pseudo=""
     CDS             <1033..1296
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="EXW41_RS12245"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12345"
                     /product="metallophosphoesterase"
                     /pseudo=""
                     /transl_table=11
                     /translation="LFYRPEFIQNYADEQIDIVLSGHAHGGQFRLPFISKLVAPNQGVL
                     PKYTTSLYEKQNTSMVVSIGLGNSIIPQRIFNRPELVVVQLN"
     gene            1505..1756
                     /locus_tag="EXW41_RS12250"
                     /old_locus_tag="EXW41_12350"
     CDS             1505..1756
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="EXW41_RS12250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12350"
                     /product="hypothetical protein"
                     /protein_id="WP_000548621.1"
                     /transl_table=11
                     /translation="MHKEYEIEEYTAIEEQIHYYCKCLLVSHPDQIIKYLEKRLEKYAE
                     TLQYAHLYPDTVILPLQQLVIEYSLDVARIRKYMNLKT"
     misc_feature    1906..1920
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            1934..2659
                     /locus_tag="EXW41_RS12255"
                     /old_locus_tag="EXW41_12355"
     CDS             1934..2659
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016087811.1"
                     /locus_tag="EXW41_RS12255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12355"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_048546950.1"
                     /transl_table=11
                     /translation="MQQPAIILRTVSKSFWKKEVLHNLSLQVEKAEIFGLVGPSGSGKT
                     TLIKLIAGINEATKGEVLVYNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKHKKERIEEVFDLVQLSKHIRQQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKTIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGKLVATGTPEELKK
                     RVSSGRIEDVFLLEEVALS"
     gene            2656..3675
                     /locus_tag="EXW41_RS12260"
                     /old_locus_tag="EXW41_12360"
     CDS             2656..3675
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="EXW41_RS12260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12360"
                     /product="ABC transporter permease"
                     /protein_id="WP_088063510.1"
                     /transl_table=11
                     /translation="MRVTGVIIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLVFTQKDYV
                     PHIAVVDVPAPIVKTMKTQEASIYEYGKEKAISELEQQKVDAVIYLENGKMNVLLEGSD
                     SSKNRAVLQVLQKSSEKNDVSVMKPEVNYLHGSKDFTMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVVGYIIGFGIFAFIQSIIIVNFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQIFFSGLFPIESMNKW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAIGNVFALKKHRKI"
     gene            3700..4353
                     /locus_tag="EXW41_RS12265"
                     /old_locus_tag="EXW41_12365"
     CDS             3700..4353
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001168192.1"
                     /locus_tag="EXW41_RS12265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12365"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_060488911.1"
                     /transl_table=11
                     /translation="MKKDWLDELIAATNTDKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLLAVVMPTLTKFAAPFFVQAFAKEIFKSKYESYEGLL
                     RVVIHNRFEFAQKHFPMIKILIQEVPFQPELKNEIQQLVETELFSHFKKLIVKFQDKGE
                     IIEIPPSSVLRLTLSAVLGLLLTRFLLLPEEKWDDEVEIENTIQFILYGLTPRI"
     gene            complement(4553..4900)
                     /locus_tag="EXW41_RS12270"
                     /old_locus_tag="EXW41_12370"
     CDS             complement(4553..4900)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000728146.1"
                     /locus_tag="EXW41_RS12270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12370"
                     /product="WGxxGxxG family protein"
                     /protein_id="WP_088063511.1"
                     /transl_table=11
                     /translation="MKKKLSSILSVLALSIIFLGTSAQAEYDGNHMNRVNNTDMSTRVN
                     DNNLNRVNDNNLNRVNDNNLNRVNNDVRTRNVNTTNDLNNNHDRNNNWAWLGLLGLAGL
                     LGLRRRDKEVR"
     gene            complement(5073..5588)
                     /locus_tag="EXW41_RS12275"
                     /old_locus_tag="EXW41_12375"
     CDS             complement(5073..5588)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000512145.1"
                     /locus_tag="EXW41_RS12275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12375"
                     /product="DUF3231 family protein"
                     /protein_id="WP_087986148.1"
                     /transl_table=11
                     /translation="MGVLSGNPQNEPMHYGEVFAIWSYLAGAQGAIAGYQVLVNHSGDE
                     DLKKFLENLIENDIQSEVEELKNLLKSNGVALPPAPPERPVASIETIPPGARINDAEIA
                     AKVSMDLAAGLVACSQAMGQSLREDVGMMFGQFHMKKAQAGATLLRLNKKKGWIIPPPL
                     HVLQSDQA"
     misc_feature    5954..5967
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 24.68"
                     /tool="antismash"
     gene            6054..7022
                     /locus_tag="EXW41_RS12280"
                     /old_locus_tag="EXW41_12380"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="EXW41_RS12280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12380"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_088063512.1"
                     /transl_table=11
                     /translation="MRQFAKPTIVVSKCLEFDACRYNAEMIPDVTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEENGVNRLVQPSTREDVTEKMEQFSYVFLQTVSDVDGFILKN
                     RSPSCGTRDVKIYSGFEKAPAKGKGSGLFGGAVIKNFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAHYKMIKHTKNIKELVSFQSDYKYLFMAYNQVKQKELGRIIANQKNETIEVVFE
                     NYEKTLYELFMRTPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLDLIQKYIEKKVPLSSL
                     LAILKSWAIRFDEKYLLRQTYFEPYPEALVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="EXW41_RS12285"
                     /old_locus_tag="EXW41_12385"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="EXW41_RS12285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12385"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_000397260.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.8e-39, bitscore:
                     132.5, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 5.3e-26, bitscore:
                     88.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 7.2e-57, bitscore:
                     190.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTVSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKYLIPMASGKTLGAFGLTEPNAGSDAGGTQTKAVLDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGVEDNGRKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKSISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANQAVQIHG
                     GYGYMREYEVERHIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="EXW41_RS12290"
                     /old_locus_tag="EXW41_12390"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="EXW41_RS12290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12390"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_000486754.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.6e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.5e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.8e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.6e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSEADENALHVKMA
                     NEAYLVGGPRVQESYLNLEKIIEIAKKTNAEAIHPGYGLLSENPSFPVRCREEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPSNVRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LHDALEELKVEGIKTNTPMLLQVLEDDVFKSGIYTTGFVTKQLVKK"
     gene            9764..9979
                     /locus_tag="EXW41_RS12295"
                     /old_locus_tag="EXW41_12395"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="EXW41_RS12295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12395"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001987345.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIISE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="EXW41_RS12300"
                     /old_locus_tag="EXW41_12400"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="EXW41_RS12300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12400"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_088063513.1"
                     /sec_met_domain="HMGL-like (E-value: 2.2e-47, bitscore:
                     160.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADANDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALVVIEDITKQALFEGKKVRGYVSTVFGCPYEGDISATAVDELC
                     NQLFSYGIYEVSLGDTIGVANPLQVERVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLKASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="EXW41_RS12305"
                     /old_locus_tag="EXW41_12405"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 4.2e-74. Score:
                     240.9. Matches aSDomain:
                     nrpspksdomains_EXW41_RS12305_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="EXW41_RS12305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12405"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_088063514.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLYRERQANSLSLALLEELQNILTQI
                     SEESNTRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIAAKSASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPAHLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRTPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW41_RS12305_ECH.1"
                     /evalue="4.20E-74"
                     /label="EXW41_RS12305_ECH.1"
                     /locus_tag="EXW41_RS12305"
                     /protein_end="254"
                     /protein_start="14"
                     /score="240.9"
                     /tool="antismash"
                     /translation="HVVKISLYRERQANSLSLALLEELQNILTQISEESNTRVVILTGA
                     GEKAFCAGADLKERAGMNEEQVRHAVSMIRTTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIAAKSASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPAHLLEEKAIEIAEKIASNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="EXW41_RS12310"
                     /old_locus_tag="EXW41_12410"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_389703.2"
                     /locus_tag="EXW41_RS12310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12410"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_075306983.1"
                     /transl_table=11
                     /translation="MLDQKQQSNTFEERVEAIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVITATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQVCLLF
                     GPSAAGGAYIPAFCDIVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPNNYLEKTPLVTPQEPKQFEKTLEQIIPENQNAPFNM
                     KDLINRVIDEGSFYEVKKLFAQELITGLARIDGKPVGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERDSFIAEKR
                     EEYKKDIDIYHLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13298..15238
                     /locus_tag="EXW41_RS12315"
                     /old_locus_tag="EXW41_12415"
     CDS             13298..15238
                     /NRPS_PKS="Domain: AMP-binding (98-521). E-value: 6.3e-82.
                     Score: 267.3. Matches aSDomain:
                     nrpspksdomains_EXW41_RS12315_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="EXW41_RS12315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12415"
                     /product="AMP-binding protein"
                     /protein_id="WP_088063515.1"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-87, bitscore:
                     291.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLYGWMKSLGYEDYETFYNKSIEETAWFW
                     GEAEKAVGYQWMKPYTEVLDLENGTPFAQWYNGGTCNVVESVLSRWLADDETRMQPALQ
                     YEGENGTSKSFTYEDLDNWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKVVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFPWSALEKEKPFTHAEEMNSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFETVGKNNVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGNPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAIGVPDDVKGEVCHCFVVFRDNVTFTGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13592..14860
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW41_RS12315_AMP-binding.1"
                     /evalue="6.30E-82"
                     /label="EXW41_RS12315_AMP-binding.1"
                     /locus_tag="EXW41_RS12315"
                     /protein_end="521"
                     /protein_start="98"
                     /score="267.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="MQPALQYEGENGTSKSFTYEDLDNWVSRVANGLKHAGIEKGDRVT
                     IYMPMIPETVVAMLAVMKIGAIISPIFSGFASDAVMTRVQAAGSKMIITADGFSRRGKV
                     VSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFPWSALEKEKPFTHAEEMNSDDP
                     LMLIYTSGTTGKPKGTVHTHAGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLF
                     GSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSL
                     KSLEVFASTGEPWNPDPWMWLFETVGKNNVPICNYSGGTEISGGIFGNVLIKPIAPISF
                     NASLPGMAAVVLDDQGNPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWV
                     HGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14084..14140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW41_RS12315_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="EXW41_RS12315"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14831..14893
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW41_RS12315_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="EXW41_RS12315"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15681..15878)
                     /locus_tag="EXW41_RS12320"
                     /old_locus_tag="EXW41_12420"
     CDS             complement(15681..15878)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002017016.1"
                     /locus_tag="EXW41_RS12320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12420"
                     /product="hypothetical protein"
                     /protein_id="WP_044440827.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDHVSSDALNTPSKAQEQMQETSQEAHDSNKKDST
                     QALHGEDLPISDVYRTTNKQ"
     gene            16196..16411
                     /locus_tag="EXW41_RS29655"
     CDS             16196..16411
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237376.1"
                     /locus_tag="EXW41_RS29655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_242475704.1"
                     /transl_table=11
                     /translation="MVIVTLAIVPGESRSEAVTVTVPGPLAARNTALKLPEALVMTARG
                     TMKAREGLLNEKLTTTPGVGLPFTNT"
     misc_feature    16431..16448
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            16457..16678
                     /locus_tag="EXW41_RS29660"
     CDS             16457..16678
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="EXW41_RS29660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_252196030.1"
                     /transl_table=11
                     /translation="MVSLEVKVIEAGPAGRLNPVGPVGPVGPVGPVEPVDPVDPVGPVD
                     PVGPVGPVEPVDPVEPVDPVEPVGPVGN"
     gene            complement(<16696..16752)
                     /locus_tag="EXW41_RS30055"
                     /pseudo=""
     CDS             complement(<16696..16752)
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="EXW41_RS30055"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLYFAALNPGSIGPTL"
     gene            complement(16951..17319)
                     /locus_tag="EXW41_RS12330"
                     /old_locus_tag="EXW41_12430"
     CDS             complement(16951..17319)
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="EXW41_RS12330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12430"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_088063517.1"
                     /transl_table=11
                     /translation="MGNIPKISSQQSNPKIPSQQVNPNTQQGNNKKTRRRIITTLAFIL
                     SVIFVLQYSLNNQQEMIKEKQITVNTEQQKLSSLKKDGHSLKNDVKALTGSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     misc_feature    17863..17876
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(17864..17877)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            17986..18366
                     /locus_tag="EXW41_RS12335"
                     /old_locus_tag="EXW41_12435"
     CDS             17986..18366
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="EXW41_RS12335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12435"
                     /product="hypothetical protein"
                     /protein_id="WP_002127497.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGSVILHNVWVFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRVLS
                     TRIALAIIGALALWMLIVIYIK"
     gene            complement(18474..18776)
                     /locus_tag="EXW41_RS12340"
                     /old_locus_tag="EXW41_12440"
     CDS             complement(18474..18776)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW41_RS12340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW41_12440"
                     /product="hypothetical protein"
                     /protein_id="WP_316245557.1"
                     /transl_table=11
                     /translation="MKGGIKECPGKMIAGVLRKSIVVMTGGNLKKRIIVMMIGVLRKSI
                     VMMIGGNLKKRIIVMMIGVLNEISVVVNVSLFVVIVKEEIGNIFNIDLKERTCLL"
     gene            19326..19640
                     /gene="exsK"
                     /locus_tag="EXW41_RS12345"
                     /old_locus_tag="EXW41_12445"
     CDS             19326..19640
                     /codon_start=1
                     /gene="exsK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000535706.1"
                     /locus_tag="EXW41_RS12345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12445"
                     /product="exosporium protein ExsK"
                     /protein_id="WP_000535565.1"
                     /transl_table=11
                     /translation="MGSRFNNCKKKCTCKQDDCWDAFEECKKEQEEQNKKCDCCCVQGI
                     RDELKKLVNRAVRITTVGNNYAGTVSSVTCDVVKLANSAGVVTVIISVCKIEAIELLLT
                     "
     gene            19782..20297
                     /locus_tag="EXW41_RS12350"
                     /old_locus_tag="EXW41_12450"
     CDS             19782..20297
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002168335.1"
                     /locus_tag="EXW41_RS12350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12450"
                     /product="GNAT family protein"
                     /protein_id="WP_142291743.1"
                     /transl_table=11
                     /translation="MIKLVPFKRSDFKQLINWINSEEFLIQWSGNAFTYPLNEQQLEKY
                     TECANTLAFKIMDEETKAVIGHISLGQIDNINKSARIGKVLVGNTKMRGRSIGKHMMKA
                     VLCIAFDELKLHRVTLGVYDFNKSAISCYEKIGFVKEGLLRESKRVGETYWNLWEMSML
                     EYEWSGKK"
     gene            20349..20909
                     /locus_tag="EXW41_RS12355"
                     /old_locus_tag="EXW41_12455"
     CDS             20349..20909
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990758.1"
                     /locus_tag="EXW41_RS12355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12455"
                     /product="AAA family ATPase"
                     /protein_id="WP_088063519.1"
                     /transl_table=11
                     /translation="MNKKTKIITVAAVSGGGKTTVTEKLTQKLTNSKALYFDSYHFKNC
                     PSDICKWIDDGANYDEWVLTPLIHDIQHLKREGNVDYIIVDYPFAYLNSEMREFIDVTI
                     FIDTPLDIAMARRILRDFKEDTIDEIHNDLKHYMTFARKAYLEAIHTVKPNSDIVLDGS
                     LSVSKIINHAVEELGLREVIVNG"
     gene            20902..21642
                     /locus_tag="EXW41_RS12360"
                     /old_locus_tag="EXW41_12460"
     CDS             20902..21642
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (27-131). E-value:
                     2.9e-14. Score: 45.2. Matches aSDomain:
                     nrpspksdomains_EXW41_RS12360_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000240893.1"
                     /locus_tag="EXW41_RS12360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12460"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_088063520.1"
                     /sec_met_domain="PF00561 (E-value: 2e-09, bitscore: 35.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.4e-09, bitscore:
                     34.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKCIEEYVQVDDFKMYTKKFQGKKLQPVIIMEAGYGDYSKAWDH
                     IAEELMEYGTVLTYDRAGLGKSGNSSKRRISSEMVKDLRSCLAQLQLKPPYIFVGHSFG
                     GINARLFATSYPKDLLGIVLVDSTPENYKEDFLPIMSPEFQEAYYKQFVYESSYEEFTF
                     SLSEVDRHCKSMNDIPLVVLAAGKKAFYSPDAQMKWLQLQEELLSLSSNNKFVIAEQSG
                     HYIQKDDPYYVIGSIKWIIEVGER"
     aSDomain        20983..21294
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW41_RS12360_Abhydrolase_1.1"
                     /evalue="2.90E-14"
                     /label="EXW41_RS12360_Abhydrolase_1.1"
                     /locus_tag="EXW41_RS12360"
                     /protein_end="131"
                     /protein_start="27"
                     /score="45.2"
                     /tool="antismash"
                     /translation="PVIIMEAGYGDYSKAWDHIAEELMEYGTVLTYDRAGLGKSGNSSK
                     RRISSEMVKDLRSCLAQLQLKPPYIFVGHSFGGINARLFATSYPKDLLGIVLVDSTPEN
                     "
     CDS_motif       21184..21219
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW41_RS12360_0001"
                     /evalue="5.60E-05"
                     /label="NRPS-te1"
                     /locus_tag="EXW41_RS12360"
                     /protein_end="106"
                     /protein_start="94"
                     /score="15.7"
                     /tool="antismash"
                     /translation="PYIFVGHSFGGI"
     gene            21645..22103
                     /locus_tag="EXW41_RS12365"
                     /old_locus_tag="EXW41_12465"
     CDS             21645..22103
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="EXW41_RS12365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12465"
                     /product="DinB family protein"
                     /protein_id="WP_088063521.1"
                     /transl_table=11
                     /translation="MYPLFQYNWQVRDDWFKWCEQLSEEELLRKRVGGVGSVLETLFHI
                     VDVEYSWISALQGKEDNEPQFKDYQSIQKVKALSDLYKRELEDFLQEWSSTVECKILKA
                     SWTDKTYTYGEVLRHVIVHEIHHIGQLSIWARELDLQPVSANLIGRGL"
     gene            complement(22162..23178)
                     /locus_tag="EXW41_RS12370"
                     /old_locus_tag="EXW41_12470"
     CDS             complement(22162..23178)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="EXW41_RS12370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12470"
                     /product="serine hydrolase"
                     /protein_id="WP_088063522.1"
                     /transl_table=11
                     /translation="MQFLKKFTILFLSFVITALIVLYFYLYVNGPIIQAKSAILIDANS
                     SEVVYKKNEETPIQSATLSKLMTEYITLEQLNEGKIQLDELVKISNEVFRAETSPIQVT
                     SKDKTTVRDLLHALFLTGNNRSALAIAEHIAGNEDNFTLLMNEKAKQLKLSQPSPFLNA
                     TGMNNDTNKQSTTTAIDVAKLATQLVKDFPDVLNVTKLTSYQFTFKDSKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNGNYSFVSTAKRGDTRLISVILDSNEENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWTVLLQFKNLIIQTLLIFFIITILMFLHIRQKKSEDFN"
     gene            complement(23359..24516)
                     /locus_tag="EXW41_RS12375"
                     /old_locus_tag="EXW41_12475"
     CDS             complement(23359..24516)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanS"
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129473.1"
                     /locus_tag="EXW41_RS12375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12475"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_060488935.1"
                     /transl_table=11
                     /translation="MRNEAFDILKDIPKWKLIFWFMLAITLTPITELIIYRLVTSVIES
                     SLTLSELGKEFIRIFGYEKYKGIKESLWMMIVSYLFLFSIFSSYLYIFYRHERKIYYET
                     CIKKMIEEIRYIANGNFNHKVSIVNHNYLEELASGVNHIVEQLKVSIDEERQAEQAKSE
                     LITNVSHDLRTPLTSIVGYVNLIHHDNYRDEVELRHYIQVIYDKVTRLNALMNDLFEYT
                     RVQNKELSLYSVPIDIVELLGQLTVQFRIQVQEANIECRPSFPSQKLMVLADGDKLVRV
                     FENLIINAIAYGNDGGYIDLAAYESNNMITIDITNYGQPIPSTDLPHIFERFYRVEKSR
                     STNTGGSGLGLAIAKSIVELHKGTIEVYSDDKKTTFTVKLQPYKC"
     gene            complement(24506..25201)
                     /locus_tag="EXW41_RS12380"
                     /old_locus_tag="EXW41_12480"
     CDS             complement(24506..25201)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) vanR"
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001038809.1"
                     /locus_tag="EXW41_RS12380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_12480"
                     /product="response regulator transcription factor"
                     /protein_id="WP_087986134.1"
                     /transl_table=11
                     /translation="MNKNILIIDDDKEIVELLAVYLRNEGYNIYKAYDGDEALQMISTY
                     DVDLMVLDIMMPKRNGLEVCQEVRENNTVPILMLSAKAEDMDKILGLMTGADDYMIKPF
                     NPLELVARVKALLRRSSFQNATSSKNEDGIIRIRSAEIHKHNHTVKVNGEYIKLTSIEF
                     DILYLLASNTGRVFSSEEIFERVWNEDGYGSNKTVMVHISNLRDKLETGMNGEKFIHTV
                     WGVGYKIEK"
ORIGIN
        1 taggagcgaa acaattattt aattctatac aaaaaataaa aatactccct gattatttgc
       61 aaatatggcc atcacatggt gcaggaagcg catgtggaaa agcattagga gcaattccaa
      121 cttctacatt aggttatgaa aagatgttca attgggcatt tcagtgtaat gaagaaagtg
      181 attttgtatc gactttattg aggggacaac cagagcctcc aaagtatttt tcattaatga
      241 agaatttaaa taagtctggt cctccaattc gtaagaagag agaagttatt gctattgata
      301 cagtagaaaa acttcaagaa gttatgagga gtgttcagca aatagttgat ataagggatg
      361 tagagagttt tgcttctggt cacatcgaga aatcaattaa cataccttat aacaattcct
      421 ttacaacttg gtgtggatgg ttactagatt ataaaacaga aactttaatc attctagatg
      481 aggaaaaggt tagagtggag gaagttatta gagactttga atctattggg ctagataata
      541 ttattgcttt tgtacctgta aaggtaatac aaagatttaa tagattagaa agttacaaag
      601 aagacacatc aatcgaatta tatccgcata taaaaagtgg aagtgttaag gtaatcgacg
      661 tgcgtagtaa aaaagagtgg gaggaaggac atcttcatga tgcaatacat atccctttag
      721 gaaatctatt taagcagcta gattgtatac caaaagattg cccaatagtt ttacaatgtc
      781 gaaccggatt gcgttccgct atagcagcta gtattttaca aagagcaggt ataaagggag
      841 tagtgaattt aaagggagga tttcttgcat ggaaaaaaga agagcttcct tatataacat
      901 gtaatcgcaa tgtgtaggga aataattttt attaatttat ccgataagga aaattgcgga
      961 ttacataggg gtatatctat atataggagc aatacagtta gatagtgtat taaaatagga
     1021 gaaatagatg atttattcta tagacctgaa tttattcaga attatgctga tgagcaaata
     1081 gatatagttt tatcaggaca cgctcatggt ggacaattta ggttaccatt tatcagcaaa
     1141 ttagtggctc caaatcaagg tgttttacct aaatatacaa ccagtttata tgaaaaacaa
     1201 aatacgtcta tggtagtaag tataggatta ggcaatagta tcattccgca aagaattttt
     1261 aataggccag aacttgtagt cgtacagtta aattgaactg tacgactttt tgtacagaaa
     1321 aaataggcca tatgcatttt atacaagtta acattacagt tttgttaaaa attttctacg
     1381 ttacataaag taacaaaatt tgacccggag agtttgttat agtgtaaata atcaaaaaac
     1441 ttaaaaatta gtcgagtgaa aagtgtgata agcaattcag taaaaaactt aaaggggtgt
     1501 acacatgcat aaagaatatg aaattgaaga gtatacggcg attgaggaac aaatacatta
     1561 ttattgtaaa tgtttattag taagtcatcc tgatcaaatt ataaagtatt tagaaaaaag
     1621 gttagaaaaa tatgcagaaa cattacaata tgcacattta tatcctgata cagttatttt
     1681 accgttacag caattagtta tcgaatattc tttagatgtt gctagaatta gaaaatatat
     1741 gaatttaaaa acgtaaaatg aaatatataa tttaaatgaa acagagtcga ctttaagaaa
     1801 tgaaattcta atgtcgactc tgtttcattg tttaagattg aaaatacata ctaatcaatg
     1861 aagtttgaca tataattacg caagagtaaa atgaaagtga gtactcactc attttgaaaa
     1921 gggggaagaa tacatgcagc aacctgctat tattttacga accgtgtcaa aaagtttttg
     1981 gaaaaaagaa gttttacaca atctttcatt gcaagttgaa aaagcagaga tatttggttt
     2041 agttgggcct tcaggttcag ggaaaacgac tcttattaaa ttgattgcag gtattaatga
     2101 ggcaacgaaa ggtgaagtgc ttgtatacaa cacgaacatg cctaatttaa atgaaatgaa
     2161 aagaattggt tatatggctc aggctgatgc attatatgaa gaactatcag catatgaaaa
     2221 tgcagatttt attgcaacga tgtatggatt aaaaggaaaa cataaaaaag aaagaatcga
     2281 agaggttttt gaccttgtac aattatcaaa acatataaga cagcaagtgc agcatttttc
     2341 gggtgggatg aagaagcgtt tatcattagc gatagcactc cttcatgaac ctgaaatatt
     2401 aattttagat gagccaacag tggggataga tccacttctt agaaaaacaa tctgggaaaa
     2461 attttatgat ttgaaaaaga aaggcacaac tattattgta acgacgcaca ttatggatga
     2521 agctgagttt tgtgagcgtt tagggttgat tagagaagga aagctagttg cgactggaac
     2581 acctgaagaa ttgaaaaaac gggtatcatc aggacggatt gaagatgtct ttttgttgga
     2641 agaggtggcc ctatcatgag agttactggt gtaatcattc gtattattcg ccaatttttt
     2701 cgagataaac gttcgttagc gatgatgttt ggggcaccaa tgttattact ttggttattg
     2761 tctctagtgt ttacacaaaa agactatgta ccgcatattg ctgtagttga tgtgcctgct
     2821 cctattgtaa aaacaatgaa aactcaagaa gcctcaattt atgaatatgg caaagagaaa
     2881 gcaatttcag agttagaaca gcaaaaggta gatgcagtaa tttatttaga gaatgggaaa
     2941 atgaatgttt tattagaagg aagtgattca tcaaaaaatc gtgctgtact tcaagtttta
     3001 caaaagagtt cagaaaagaa tgatgtatca gttatgaagc ctgaagtaaa ttacttacat
     3061 ggctctaaag actttacaat gtttgatggg cttggccccg tattgattgg tttctttaca
     3121 tttttctttg tatttatatt atctggagtt tcttttgtta gagaacgttt aagtggtaca
     3181 ttagagaggt tattgtccac tccagtgaga agatgggaaa tagttgtagg atatattatt
     3241 ggttttggaa tctttgcatt tatacaatca attataatcg tgaatttttc agtttatatt
     3301 ttagacttgt atgtagctgg ctccatatgg ctaacgctac ttattacatg tatgctttct
     3361 ttaacagcac taactttagg gacattttta tcagcatacg caaataatga atttcaaatg
     3421 attcaattta taccgcttgt cattgtgcca caaattttct tttctgggtt gtttccaatt
     3481 gaatctatga ataagtggct acaaatgtta gggaaattat ttccgctcac atatggagct
     3541 gacgcaatga gacaagtgat gattcgaaat caaggattta cagagattgc gttagatcta
     3601 actgtattac tacttttttc tctattattt gcaataggga atgtatttgc attaaagaaa
     3661 catcggaaaa tataatgatg atacaaaggg gtattataga tgaagaagga ttggttggat
     3721 gaattaattg ccgcaactaa tacggataaa cgaaatgaac gtcaaatgcg tattttagag
     3781 gcagctgttg atatgtttgg agaaaaagga tatgcatcaa cttctacaag tgaaattgca
     3841 aagcgtgctg gtgtagcgga aggaacaatc ttccgctact ataaaacgaa aaaagattta
     3901 ttgttagcag tcgtcatgcc gacattaaca aagtttgctg caccattttt cgtacaagcc
     3961 tttgcaaagg aaatatttaa atcgaagtat gaatcatatg agggactttt acgagttgtc
     4021 attcataata gatttgaatt tgctcaaaag cactttccta tgattaaaat attaattcaa
     4081 gaagtaccat ttcaaccaga gctaaaaaat gaaatacaac aattagtaga aacggaactg
     4141 ttttcacatt tcaaaaagtt gattgtgaag tttcaagata aaggagaaat tattgagata
     4201 ccaccatctt ctgtattacg tcttacttta tcagctgtat taggtttact attaacacga
     4261 tttttattat tgcctgaaga aaaatgggat gatgaagtgg aaattgaaaa tacgattcaa
     4321 tttatattgt atggattaac gccacgaatc taactataac aacattttag gggtttgatt
     4381 tttggtattt aaataaatgt aatttaatag gtttaatcat aagtaaaaat atgttgatgt
     4441 gtgaattaca tatactattt ttaagcaaat aataaatcgc ctttaaaaag gcgatttata
     4501 ttcattatac aattttgata aataagtact tgtttacgaa aaacattcta gattaacgta
     4561 cttctttgtc tcttcttcta agacctaata atcctgctag acctaataaa cccagccaag
     4621 cccaattatt atttctatca tgattattat ttaaatcatt tgtcgtattt acatttcgag
     4681 ttctcacatc attattaact ctgttcaagt tattatcatt aactctgttc aagttattat
     4741 cattaactct gttcaagtta ttgtcattaa ctcgagttga catatcagtg ttattaactc
     4801 tattcatatg atttccatcg tattcagctt gggcagatgt gcctaaaaat ataatagata
     4861 gtgctaaaac acttaaaata gatgataatt ttttcttcat aaatttcccc tcctttctta
     4921 tgtattaatt tctccattgc ttttgtacat tattcgtatc acagtatcta aatcataaag
     4981 ttaaaattat tagaactatc tttaatctcc attattaaaa ggacaggtaa atacaacgaa
     5041 gcggttaaca aaagttaacc gcttacgcca tgttatgctt gatcagattg aagaacatgt
     5101 aaaggaggag gaataatcca gccttttttc ttatttaacc gtagtaaggt agcacctgct
     5161 tgtgcctttt tcatatggaa ttgtccaaac atcattccta cgtcttctcg aagtgattgt
     5221 cccatcgctt ggctacatgc tactagtcca gcagcaagat ccatagaaac tttagctgca
     5281 atttctgcgt cattaatacg agcaccagga gggattgttt caatagatgc aactggacgc
     5341 tctggaggtg ccggtggtaa tgccacaccg tttgatttta acaagttttt tagttcttca
     5401 acttctgatt ggatatcatt ttctataaga ttttctaaaa acttttttaa gtcctcgtct
     5461 ccagaatgat tgacaagaac ttggtaacca gcaattgcac cttgtgcccc tgcaagataa
     5521 ctccaaattg caaagacttc tccgtaatgc attggttcat tttggggatt accacttaat
     5581 actcccattt taatatgcct ccttaaaatg aatggatttt ttgaaatatt ttttaccaaa
     5641 gaaaaaatgc ttctgaaaat gttccgtaat aaagaaagta ggtttctaaa attcatttgg
     5701 aacaccctaa ctacaagtaa tactttctca gtctataatg tacaaatata aagaatatat
     5761 tccaaataac ttgggattaa aattcgtatt aagacttatt ttaatttaaa tgtaaagagg
     5821 agaggaaaga atctgtaact atgctagtaa agatggattg tgtttagaca aaaatgtatt
     5881 aacaagtttg tacaagaact tgttaataca tatacgaaat agatttgaat tgcagttgat
     5941 atggcattaa atttatagtt attataaaaa taatcaatat aaacagactt tgcttaagat
     6001 actaatatca gtacaattta gattgtatgg attgatacca tggaggtaat gaaatgcggc
     6061 aatttgcaaa accaacaata gttgtaagta aatgtttaga atttgatgcc tgtcgttata
     6121 atgcagagat gataccagat gtaacaatac gaaatttgca gccatttgtt acatttatac
     6181 ctgtttgtcc agaagtcgag atcggattgg ggactcctcg tgaaacgata cgaattgtag
     6241 aagaaaatgg tgtgaatagg cttgtacagc cgtcgacacg agaagatgta actgaaaaaa
     6301 tggagcaatt ttcatatgtc tttttacaaa cggtatctga tgtggatggt tttattttaa
     6361 agaatcgttc gccgagttgt ggtacgcgtg atgtgaaaat ttattctggt tttgaaaaag
     6421 caccagcaaa aggaaaggga tctggcttat ttggcggagc agtaataaaa aatttttcgc
     6481 atcttccaat tgaagaagag ggtagattgt cgaattttat tattagagaa catttcttta
     6541 caaggctgtt tacaatcgcg cattacaaaa tgattaaaca tactaaaaac ataaaagaac
     6601 tcgtatcatt tcaatcagac tataagtatt tatttatggc atataatcag gtaaaacaaa
     6661 aggaattggg gcgtattatt gcaaaccaaa aaaatgaaac gattgaagtg gtatttgaaa
     6721 actatgagaa gactttatat gaattattta tgcgcacacc ccgctataca tcgaatgtaa
     6781 atgtatgtga gcatattttt ggatatttta aaactaagct gaaaaaacaa gaaaaagatc
     6841 attttttaga tttgatacaa aagtatatag aaaagaaagt cccgcttagt agcttacttg
     6901 caattttaaa atcatgggcc attcgatttg acgaaaagta tttattaaga caaacatatt
     6961 ttgaacctta ccctgaagct ttagtagaaa tttctgattc gggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacaagaaa actcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattagtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attgtctaac taatattcgt gtcttttaat tcgtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg actttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcggaatttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggaatccca ttccctgaag agtatggagg ttcaggtggc gatactgtat
     7441 cgtacgcgtt agcagttgaa gaaattggtc gtgcttgtgg tgggacagga ttaagttacg
     7501 ctgcaacaat ttctttaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 agaaatattt aattccaatg gcatcaggta aaactttagg tgctttcgga ttaactgagc
     7621 cgaatgctgg atctgatgca ggtggtacac aaacgaaagc tgtattagat ggagacgagt
     7681 atgttattag tggtgaaaag tgttggatta caaatgcaga gtatgcaaat acaattattg
     7741 taaccgctat caacggtgtt gaagataatg gtagaaagcg tatttcggca tttatcgtac
     7801 cgactacaag tgaaggatta acgatttcaa gtccttacga taagatgggt gttcgtgctt
     7861 ctaatacatg tgaaatcgta cttgatggtg tacgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaatcg
     7981 cagcattagc agtaggtatt gcacaatctg catttgaacg tgcgctgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaag tcaatctcta atttccaagc gattcaattt aaattagctg
     8101 atatggcgac tgaagtagaa cttgcacgta atttagtaca taaagcggct tggttaaaag
     8161 ataatgataa acctttcggt aaagaagcgg ctatggcaaa gttatttgca tctgaggctg
     8221 ctagtcgtat tgcaaatcaa gcggtacaaa ttcacggtgg atacggctat atgcgtgaat
     8281 atgaagtgga acgacatatt cgtgatgcaa aactattaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gcaagacatt taggatgtag ataaaaagga ggaatcacta
     8401 tgtttcaaaa aatattaatt gctaatcgcg gggaaatcgc agttcgtatt atgaaaactt
     8461 gtcaaaaact tggcattcgc actgttgcta tttattctga ggctgatgaa aatgccctac
     8521 atgtaaaaat ggcaaatgaa gcttacttag taggtggacc gcgtgtccaa gaaagctatt
     8581 taaaccttga aaaaattatt gaaatagcta agaagacaaa tgctgaagca atccatccgg
     8641 gatatggatt attatcagag aatccatctt ttccggttcg ctgtagagaa gaaggaattg
     8701 tatttatcgg tccatctgaa gaaattatta cgaagatggg aagtaaaatc gaatctcgta
     8761 ttgcaatgca agctgcagat gtcccagtag ttccaggtat tactacaaat attgaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc attaatgctg aaggcatccg
     8881 caggcggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagtaa caaaacaaga gcacaaaact tcttcggtaa cggagaaatg tatttagagc
     9001 gctatattgc agatgcacat catattgaaa ttcagctttt agcagataca catggtaaca
     9061 cagtgtattt atgggagcgt gaatgttccg tgcagcgccg aaatcaaaaa gtaattgaag
     9121 aagcaccttc accattttta gatgaaggta cgcgaaaagc gatgggggaa gttgctgtac
     9181 aagctgccaa agctctaggc tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 agaagaactt ttatttctta gagatgaata cgagattaca agtagagcat ccagttacag
     9301 aagaaattac aggtttagat cttgtagaac aacaacttct aattgcatac ggtgagaaac
     9361 tatcatttac acaagatgat gtaaaacgta gtggtcatgc cattgaggca cgtatttatg
     9421 cagaggatcc gaaaactttc ttcccatcac ctggaaagat tacagattta acgcttccat
     9481 caaatgtacg tattgatcac tttttggaga atcaagtcac gattacacct ttctacgatc
     9541 caatgattgc gaaagtcatt gctcatggtg aaactcgtga agaagcaatt tcaaaattac
     9601 atgatgcttt agaagagtta aaagtagaag gtattaaaac gaacacgcca atgttacttc
     9661 aagtattgga agacgatgtg ttcaaaagtg gtatttatac aacaggtttt gtaacgaaac
     9721 aacttgttaa aaaataaggt ttaacaatat taagggggaa aaaatgatga cgaaggtata
     9781 tgcatcgatg gcaggaaatg tatggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tagaatctat gaaaatggaa attccaatca tttcagaaga
     9901 agctggcaca gttatgaaaa ttaatgtgca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacaaaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaggcg ggattatcgt acgttgaagt
    10141 ttcctcattc gttcacccta aatgggtccc tgcattagca gatgcaaatg atgtgttttc
    10201 tgagctgaaa agggatccca atgttactta tgcagcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcataataaa agtaatatta ataaatcaat taaagaagca ttagttgtaa ttgaagatat
    10381 aacaaaacag gcattattcg aaggaaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgccac agcagttgac gaattatgta atcaactatt
    10501 ttcatacggc atttatgaag tatctcttgg tgacacgatt ggtgtagcga atccactaca
    10561 agtagagcga gtattagaac atttattaaa gaaatatgat gcttcgcagt ttgcaatgca
    10621 cttccataat acgtatggaa tggctctggc gaatgtagtt aagtcattag aatatggtat
    10681 tacaacattt gatagttctt gtggtggtct tgggggctgt ccatatgcac caggagcatc
    10741 aggcaatgtt gcaaccgatg acttagttca tatgcttcat aagttagggg tccaaacgaa
    10801 tattgatgaa gagaagttat tgaaagcgag tcaattcatt caaagtaaat taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tacaattaca aaacatttca gttgattatg taacacctca cgttgtaaag atttcattat
    10981 atcgtgaaag acaagcaaac tcattatctt tagcgttatt agaagagtta caaaacatat
    11041 taactcaaat aagtgaagag tccaatactc gtgtagttat tttaacaggt gctggtgaaa
    11101 aagcgttttg tgctggtgct gatttaaaag aacgtgctgg tatgaatgag gaacaagttc
    11161 gccatgctgt tagtatgatt cgcactacta tggagatggt tgaacaatta ccacagccag
    11221 ttattgctgc tataaacgga atcgcccttg gtggtggtac ggaattaagt ttagcttgtg
    11281 attttagaat tgcggctaaa tctgcaagtc ttggtcttac tgaaactaca cttgcaatta
    11341 taccaggagc aggtggtacg cagcgtttac caagattaat tggtgttggt agagcgaaag
    11401 aattaattta tacaggcaga cgtatttcag cgcaagaagc aaaagaatat ggtttagtag
    11461 aatttgttgt accagctcat ttacttgaag agaaagcgat tgaaatagca gagaaaattg
    11521 ctagtaatgg tcctattgct gttcgattag caaaagaagc aatttcaaac ggtattcaag
    11581 ttgatttaca taccggatta caaatggaaa aacaagcgta tgaaggtgta atccatacga
    11641 aagatagatt agaaggatta caagcattca aggaaaaacg cacaccaatg tataaggggg
    11701 agtaaatatg ttagaccaaa aacaacaatc gaatacattt gaagaacgag ttgaagcgat
    11761 taaacaaggc ggcgcaccaa agtatcatga acaaaacaaa gcaaaaggaa aactattcgt
    11821 tcgagatcgc ttagctcttt tatttgataa tggtgaatat gtagaagatg cattatttgc
    11881 aaattgtgaa caaacaggat tacctgctga tggtgttata acggcaacgg gtaaaataca
    11941 tggtcgtact gcatgcgtaa tggcaaatga ttcaacggta aaggctggat catggggcgc
    12001 acgtacagtt gaaaagattt tacgtattca agaaacggca gaaaaattac gtgttccgtt
    12061 attttattta gttgactctg ctggagcgcg tattacagat caagtagaaa tgttcccagg
    12121 gcgccgcggt gcaggaagaa tcttctacaa tcaagtgaaa ttatcaggta aagttcctca
    12181 agtatgctta ttatttggac cttcggcagc tggtggcgca tatattccag ccttttgtga
    12241 cattgttatg atggtagaag gaaatgcatc tatgtactta ggttctcctc gtatggcgga
    12301 gatggttatc ggcgagaagg taactttaga ggagatgggt ggagctcgta tgcattgctc
    12361 tgtatcagga tgcggagatg ttttatgtaa aacagaagaa gacgcgatta cacaagcaag
    12421 acaatacatt tcatattttc caaacaacta cttagagaag actccattgg ttacacctca
    12481 agaaccgaaa caattcgaaa aaacgttaga acaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaatagagt tattgatgaa ggttctttct atgaagtgaa
    12601 aaaattattt gctcaagaac taattacagg cttggcacgt attgatggta agccagttgg
    12661 tattattgca aatcaaccgc gtatgaaagg cggcgtatta ttccacgatt cagcggataa
    12721 agcagcgaag tttattaatt tatgtgatgc atatcatatt ccattgttat tccttgcaga
    12781 tgtacctgga tttatgattg gtacaaaagt agagcgtgct ggtattattc gtcatggtgc
    12841 aaagatgatt tctgcaatga gtgaagcaac tgtaccgaaa atttctatcg ttgttcgtaa
    12901 agcatacggt gctggtttat atgcaatggc aggtccagcc tttgaaccag attgctgcct
    12961 agcattaccg acagcttcta ttgcagtaat gggtccagaa gcggcagtca atgctgtata
    13021 tgcaaataag attgcagctt taccagaaga agagcgtgat agcttcattg ctgaaaaacg
    13081 cgaagagtat aagaaagata ttgatattta ccatttggca tcagagatgg ttattgatgg
    13141 tattgttcat ccaaacaatt taagagaaga gttaaaagga cgattcgaaa tgtatatgag
    13201 taaatatcaa gtatttacag atcgtaaaca tcctgtttat ccagtttaaa gccctattta
    13261 gggctttctt gctcaaaaag tcaaggaggg gaaaacattg aaacaagcag tttggtttcc
    13321 aacagaagaa tataaagaaa aaacgcgttt atatggttgg atgaaatcat tgggctatga
    13381 agattatgaa acgttttata ataaatctat tgaagaaaca gcatggtttt ggggagaagc
    13441 tgagaaagcg gttggctatc aatggatgaa gccttataca gaagtgctag atttagaaaa
    13501 tggtacaccg tttgcacagt ggtataatgg tggaacatgt aacgttgtag aatcagtttt
    13561 atcacgctgg cttgcggatg atgaaacaag aatgcaacca gcactacagt atgagggaga
    13621 aaatggaact tcaaaatcat ttacatatga agatcttgac aactgggtaa gtcgcgttgc
    13681 aaacggtttg aaacatgcgg gtattgaaaa aggtgaccgt gtaacaattt atatgccgat
    13741 gattccagaa acagttgttg caatgctagc tgttatgaaa atcggagcaa ttatttcacc
    13801 aatattctca ggatttgcgt ctgatgcagt catgactcgt gtacaagcgg cagggtcaaa
    13861 aatgattatt actgcagatg gtttttcacg ccgaggtaaa gttgtttcat taaaagacga
    13921 agtagataaa gcttgcgaac attgtccaac tgttgaaaaa gttgttattg ttcgtcatgc
    13981 aggaaatgat tttacaccac ataattatga tttcccatgg agtgcgctag aaaaagaaaa
    14041 accatttacg cacgctgaag agatgaatag tgatgatccg ttaatgctca tttatacatc
    14101 aggtacaact gggaaaccga aaggaacagt acatacacat gctggtttcc ctttgaaatc
    14161 tgcatttgat gcaggatttg gaatgaacat caaacaaggt gaccgcgtat tatgggtaac
    14221 tgatatgggc tggatgatgg gaccgttttt attattcggc tctctcatta atggagcaac
    14281 gatggttatg tacgaaggtg ttccagattt cccagaagca gatcgtttat gggagaccgt
    14341 tgataaatat gaaattacac atctcggtat atcaccaaca ttaattcgtg cgttaatggc
    14401 aaagggtgat gagtatgtaa ataaacattc gctcaagagt ttagaagtat tcgcatcaac
    14461 aggtgaacct tggaatccag atccttggat gtggctattt gaaacagttg gaaaaaataa
    14521 tgtaccaatt tgtaactatt caggcggaac tgaaatttct ggtgggattt tcggaaacgt
    14581 ccttattaaa ccaattgcac cgattagttt taacgcatct ttaccaggaa tggcagcggt
    14641 tgtgctcgat gatcaaggca atccaattcg tgatgaagtt ggagaattat gtttagagaa
    14701 accttgggtt ggtatgacga aaagtttctg ggaagacgat gagcgttatg tgaacacgta
    14761 ttggtcacgt tttgaaaata aatgggttca tggtgactgg gtgatttatg atggtgagca
    14821 atatattatt acaggacgct cagatgatac gttaaacatt gctggaaaac gtattggacc
    14881 tgcagaatat gaatctattc ttgtgaagca taatgatgtc atagaagctg ccgcgattgg
    14941 tgtacctgat gatgtaaaag gtgaagtttg tcattgtttt gtagtattta gggacaatgt
    15001 aacattcaca ggagagttaa agaaagaatt aatgagttta gtaaactctc atatcggaaa
    15061 agcattgtgt ccaaaagata ttcacgttgt agaagattta ccaaaaacac gtaattctaa
    15121 agtaatgcga cgcgtcatta aagctgctta cttaggaaaa gagttaggag atttatcgtc
    15181 acttgtaaat cctgaagtag ttccgtttat tcaggggtta cagtctagca aactataaaa
    15241 ttacgaatga gctctattta catagagctc atttttaatg tttacaaaaa gataagagag
    15301 aaaaagtaaa tttaaagtta aaaaatctac tattagtgtt aagtatatct gtttgttttt
    15361 agtttttatc aaaataggat actatggctg tctattcaat ggagtgattg aattttgtta
    15421 agaatgaaaa tttagtgaag aaaaaagtaa tgaataaaag gagaaatccc tgggggacag
    15481 ggattcaata agggagatat cattgtcgtt caatgtcgaa atttggcgta tccgacaaat
    15541 taatattatc acgaattttc aggagattgt gatagtggat gtgtcaaaaa tgtgtacggg
    15601 tttcatataa aagtgttatt taaataggaa aagggaaaag aattaagttc actggttctt
    15661 aagatttttc ccttttaaat ttactgtttg ttcgttgttc tatatacatc tgaaattggt
    15721 aaatcttcgc catgtaaagc ttgagtactg tcctttttgt ttgaatcatg tgcctcctga
    15781 gatgtttctt gcatttgctc ttgggcctta ctaggagtat tcagcgcatc tgatgacaca
    15841 tgatcaagtt gttgacttaa taaatctttt ttatccatgt tatgtagctc ctttttgaac
    15901 ttagatataa aaacgaagtg cttttaaata gttacgtggg tattatgtat ctttgaatgg
    15961 aattatatac ataaactata ttgagaattt aactaattat aaaaattact tgtgatgaca
    16021 agcttaagaa atataaagat cattagttct taataaaagc gttattttag tagggtgtta
    16081 cgaaatttta tttgaaagga acatcccaat gataaaaaag agcactgtaa atcagtgctc
    16141 atcttattag atattgctta gtccttaaaa ataaaaccat tatggacaat tcacaatggt
    16201 aatagtgacg ctagccattg ttccaggaga atcaagaagt gaagcagtaa cggttactgt
    16261 tccaggccca ttagcggcta gaaatacagc gttaaagtta cctgaagcat tggtaatgac
    16321 cgcaagagga accatgaaag caagagaagg gttactgaat gaaaaactga ccactactcc
    16381 tggagtagga ctaccgttta ctaatacttg acccgaaaaa aataaagtat tatttccttg
    16441 agtggataca catgctgtgg tttcgttaga agtcaaggta atagaggcag gcccagcagg
    16501 aagattaaat ccagttggtc cagttggtcc agttggtcca gttggtccgg tagaaccggt
    16561 tgatccggtt gatccggttg gtccggttga tccggttggt ccagttggtc cggtagaacc
    16621 agttgatccg gttgagccag ttgatcctgt agaaccggtg ggaccagtag ggaattgaaa
    16681 gggttgaaca ggtggaagtg taggtccaat agaacccgga ttaagtgcag caaaatataa
    16741 aaactcgtcc attatttatc acctctaaaa atcgtattac taatagtaaa tgtaatgata
    16801 gagcaatgtg aaatggacaa gcggttgtat tttaataaat taaacaaaat agttatttga
    16861 tagaaaaaga aattagtatg tttattttag aaattaaata taaaaaggcg attatcgtca
    16921 aatcgccttt ttgggtaatg cagtgtaatt ttattcagtt atttgaaata tagtttcatt
    16981 cggtttggaa aatccataca gtttccttgc gaattttaaa atctcttctt cactacctgt
    17041 taaagcctta acatcatttt taagggaatg accatccttc tttaaagaag ataatttttg
    17101 ttgctccgta ttaaccgtga tttgtttttc tttaatcatt tcttgttggt tattaagaga
    17161 atattgaagg acaaaaatta cagataatat aaaagccaaa gtagttataa tacggcgtct
    17221 tgttttttta ttattacctt gttgggtgtt agggttcact tgctgtgagg gtatcttagg
    17281 atttgattgt tgtgatgata tttttgggat gtttcccatt aaaatgcctc cattactgat
    17341 tgtagaattt aaactgttta aaagtattat aaatgttcaa tgggaatttt agaagatagt
    17401 ttaatatagg tgagttttgt aaagtttaaa caaaatcctt atttaaataa aaggaacccc
    17461 gattgtctgc agggctccta agggtaatcg tcaagtaatg acgtactcga ctagttaacg
    17521 atatcatgaa ttttttggta aatatactgg taaatgcgtc caaattaatg agagcattat
    17581 ttgaaacaaa aacgctattt taatagggag gggaataatg atgattccat gggacaagcg
    17641 agtatacatt gtattaaggt gatcatttta ttacagaggg gacaatttta gaggttagtg
    17701 aaaaggcgaa taaatcatta tattggcttt ggtgcatgtt agctccaagc tatgaaaaag
    17761 tgtgcggtaa tagtacaaag cgacttcggt tgattcggat agatgatgat gaagaatgat
    17821 ataaaaattt cattttgtag agaaatgagg tgattaagga tgggcataga atatgccatg
    17881 tttgtattaa aaaagagcag aatttagcct atatataaag atgttggaat tgttctaaag
    17941 gggggaatat ctgaaatata aataattgag gggagtgaac taataatgga aactagtact
    18001 tttttaggat tgttttgggg atggataacg gttatcgtat cgggaatact tttcgtacgt
    18061 ccatcggtac tacgtgaatt gaaaaaatta gtggttgaag acagaggatt tggtattatg
    18121 tatggttttc tatcgatttt cctagggtta ggtagtgtaa tcctacataa tgtatgggta
    18181 ttcaattggc aggggttcct aacggttatt gcatggcttg cattattaaa gggaatctac
    18241 ataattgcat atcctgaacc ctccaagaaa acagactttg aattaagggt actatctaca
    18301 cgtatagcgc tcgctatcat tggcgccttg gctttatgga tgcttatagt aatctatata
    18361 aaataatcct tttctaataa gaactatatt aaaataaatc tctacgtgtt cattgacaaa
    18421 aagctgacta tacttagtca gctttttgta tattacattc tagtatttat cggtcacaaa
    18481 agacatgttc tctcttttaa gtcgatattg aaaatattac caatttcttc ttttacaatg
    18541 acaacaaata aagaaacatt tacaacgaca cttatttcgt ttagaactcc aatcatcatc
    18601 acaatgattc ttttctttag atttccacca atcatcatta caatgctttt ccttagaact
    18661 ccaatcatca tcacaatgat tcttttcttt agatttccac cagtcatcac aacaatgctt
    18721 tttcttagaa ctccagcaat catttttcca ggacattctt ttatacctcc cttcaatagg
    18781 attcatacta ttctatgttt tagtaaaaga atggcttgtt tattaaccta ttattttacc
    18841 tttatatgat agagtgcttt ctactagata tagaattcat acaaactatg ctaattttca
    18901 ggagatagtt gagagaacta ctggttatga tattaatcaa caaacacttg ttgaaggaaa
    18961 cgttaagatt ttaaataata tcttattttg gagtacgctt ttttgaatgt atatttcaca
    19021 acagcaaagg tactatatta atgcaaacaa agcctatgta tatggtatat gtgaagtaat
    19081 aggaaaagct ggggactctt aaaggagctg acttataaga ggttgtctaa actttaaatt
    19141 cagcagaatt aaatccaatt cccctcatta aacaagcttc aaattgttag aggcctgttt
    19201 ttatagttaa taaagaaaag aatgtctaat acaattgttt gttttttcct ttctatgtgt
    19261 ttgtctctta cacttttaag cttgtggaca tactttacta atagaaagga ttagggggtg
    19321 aggttttggg ttctcgattt aataattgta aaaagaagtg tacatgtaaa caggatgatt
    19381 gttgggatgc tttcgaagaa tgtaaaaaag aacaagaaga acaaaataaa aaatgcgatt
    19441 gttgctgtgt acaaggaatt agagatgagc ttaaaaaatt agtaaacaga gccgtgcgaa
    19501 ttactacagt aggaaataat tatgcaggaa ctgtttcttc agtaacttgc gatgttgtaa
    19561 agcttgctaa tagtgctggg gtagttacgg taattatttc tgtttgtaaa attgaagcga
    19621 ttgaactttt gttgacatag gaaaatagca taattatgcc gttttttgta aagccattct
    19681 tatgaatggc tttattttaa tttcgtataa aaggagaata tattctttat atagaaatag
    19741 gtttgaggct ataaagagtg atgtacgaac ggagaatgag agtgattaaa ttagtaccct
    19801 ttaaaagatc tgatttcaaa caattaataa attggattaa ttccgaagaa tttttaatac
    19861 aatggtcggg aaatgcattt acatatcctt taaatgaaca gcaattagag aaatatacag
    19921 aatgtgcaaa cacactggca ttcaaaataa tggatgaaga gactaaagca gttattggtc
    19981 atatttctct tggacaaata gataatataa ataagtctgc tagaattgga aaagtgctag
    20041 ttggtaatac gaaaatgaga gggcgttcta tagggaaaca tatgatgaaa gccgtacttt
    20101 gtattgcttt tgatgaatta aaactacata gagtaactct tggtgtttat gactttaata
    20161 agtcagctat ttcttgttac gaaaaaatag gttttgtaaa agaaggttta ttaagagagt
    20221 caaaaagagt aggagaaacg tattggaatt tatgggaaat gagtatgtta gaatatgaat
    20281 ggagcggtaa aaaataatag ttatctataa ctatgttatg ttaattaaaa ggggtatggt
    20341 gggaaattat gaataaaaaa acgaaaatca ttacagttgc agctgtttca ggaggaggta
    20401 aaactactgt tacagaaaaa ttaactcaaa agttaacaaa ttcaaaagca ctatattttg
    20461 atagctatca ctttaaaaac tgtcctagtg atatttgtaa atggattgat gatggagcaa
    20521 attatgatga atgggtactt acgccattaa ttcatgatat tcagcacctt aaacgagagg
    20581 gtaatgtaga ttatattatt gtagattatc cttttgcata cttaaatagt gaaatgcgag
    20641 agtttattga tgtaactata tttatcgata cacctttaga tattgcgatg gctagaagaa
    20701 ttttgcgaga ttttaaagaa gatacaatag atgaaataca taatgatttg aaacattaca
    20761 tgacatttgc gagaaaagca tatttagagg caattcatac tgttaagccg aattcggata
    20821 ttgtattgga tggctcttta tctgtaagta aaataattaa tcatgctgta gaggaacttg
    20881 gcctgagaga agtgattgtc aatggttaaa tgtatagagg aatatgtgca agttgatgat
    20941 tttaaaatgt atacgaaaaa gtttcaagga aagaagctgc agccagttat tataatggag
    21001 gcaggttatg gcgattattc aaaggcgtgg gaccatattg ctgaagagtt gatggaatat
    21061 gggacggtac ttacatatga tcgagcggga ttagggaaaa gtgggaacag ttccaagaga
    21121 cgtattagtt ctgaaatggt aaaagattta agaagttgct tagcgcaact acaattgaaa
    21181 ccaccttata tttttgtagg acattctttt ggcggtataa atgcacgttt atttgcgact
    21241 tcttatccca aagatttgtt gggaatcgtt ttggttgatt cgacaccgga aaattataaa
    21301 gaagattttc tgccaatcat gtctccagaa tttcaagaag cttactataa acagtttgta
    21361 tatgaaagtt cttatgaaga gtttacattt agtttaagtg aagtagatag acattgtaaa
    21421 tcaatgaatg atattccact tgtcgtgtta gctgcgggta aaaaagcttt ttattcgcca
    21481 gatgcacaaa tgaaatggtt acaattgcaa gaagaattat taagcctatc aagcaataat
    21541 aaatttgtaa ttgcagagca aagcggccat tatattcaaa aagatgatcc gtattatgta
    21601 ataggttcta ttaaatggat tattgaggta ggggagagat aaaaatgtac cctttatttc
    21661 aatacaattg gcaagtaaga gatgattggt ttaagtggtg tgaacaactt tcagaggaag
    21721 aattactccg caagcgtgta gggggtgttg ggagtgtttt agaaacatta ttccatattg
    21781 tcgatgttga gtacagctgg attagtgcgc ttcaaggaaa agaagataat gaaccgcagt
    21841 ttaaagatta tcaatcaatc caaaaagtga aagcgttatc tgatttatat aaacgagaat
    21901 tagaagattt tttacaagaa tggtcatcta ccgtagaatg taagatatta aaagcttcgt
    21961 ggaccgataa aacatataca tacggtgaag ttttaagaca tgtaattgtg catgaaattc
    22021 atcatatcgg tcagctatct atatgggcga gagagttaga tcttcagcct gtttcagcga
    22081 atttaattgg aagaggatta taaatttaga aaccggcttg cactgtaaat gcaagccggt
    22141 ttttatataa aagaagattt cctagttgaa atcctcggat tttttctgac gtatatgtaa
    22201 aaacattaaa attgtaatga tgaagaaaat caacaatgtt tgtatgatca aatttttaaa
    22261 ttgaagcaaa actgtccacg atgtaacagc atctttaaaa gcttggagtg cagagtacga
    22321 ggaaggatca aaaccgtact gtagtaactt ttttgtttca ataaaagtac tgttttcttc
    22381 attggagtct aatattacgg aaataagtct agtatctcct cgttttgctg tactaacaaa
    22441 actataatta ccattagttg aaaaactagt ttgtaagccg tcaacacctt ggagtttaat
    22501 gtttttatta agagaataaa tcattttatt tgtgttgaaa acttttgagt ctttgaaggt
    22561 aaattggtaa gaggttagtt tcgtaacatt caatacatct ggaaagtctt ttactaattg
    22621 tgtcgctagt ttagctacgt ctatagctgt tgtagttgat tgtttatttg tatcgttatt
    22681 cattccagta gcatttagaa acggggatgg ttgtgataac tttagttgtt ttgctttctc
    22741 attcattaaa agtgtaaagt tatcttcgtt tccagcaatg tgttctgcaa tggcaagtgc
    22801 ggaacgatta ttccctgtca aaaacaatgc atgaagtaaa tcacgaactg tcgttttatc
    22861 tttcgaagtt acttgtatag gactcgtttc tgctcggaaa acttcgttac ttatttttac
    22921 taattcatct aactgtattt ttccttcatt cagttgttcc agtgtgatat actctgtcat
    22981 taatttagat aaagtggctg attgtatagg agtttcttca ttttttttat aaacaacttc
    23041 acttgaatta gcatctatta aaatagctga tttagcttga ataattggac catttacata
    23101 gaggtaaaaa tataaaacga taagtgctgt aataacaaaa gataagaata aaattgtgaa
    23161 ctttttcaag aattgcataa gcgatcctcc tactatgaca tcaataatac tattgtaaaa
    23221 aggaatgctt aattaggaag aaagaaaagg taaagaattt ctaaagaatt ataaaggatt
    23281 attaaatttg gattttaatg gaaaataaaa gatccaattt cttatatggt aagaaattgg
    23341 atctaaaatt aagttgtatt aacatttata tggttgtagt tttacagtga aagttgtttt
    23401 tttatcatca ctatatactt caatagttcc tttatgcaat tccacaatac tttttgcaat
    23461 tgccaatccg agtccagatc caccagtgtt cgtagagcga gatttttcaa cgcgataaaa
    23521 acgttcaaaa atatgaggta aatccgtact aggaataggt tggccgtaat ttgttatatc
    23581 tatagtaatc atattattgc tttcataggc agcaaggtcg atatatccac cgtcgtttcc
    23641 ataagcgata gcatttataa taagattttc aaacactcgt actaatttgt ctccatcagc
    23701 taataccatg agtttttgag atgggaaaga aggtcgacat tctatattag cttcttgaac
    23761 ttgtatgcgg aattgaacag ttaattgccc aagtagctct acaatatcaa tgggaacaga
    23821 atataagctt aactctttat tttgaacacg tgtatattca aacaaatcat tcattaatgc
    23881 gttaagacgg gttactttat cgtaaatgac ttgtatataa tggcgtaatt ccacttcatc
    23941 tctataatta tcatggtgga ttaaatttac gtatccaact atagaggtaa gaggagtacg
    24001 taaatcatgc gatacatttg taataagttc actttttgct tgttcagcct gtctttcttc
    24061 atcaatcgaa actttcaatt gttcaacaat gtgattaacc ccgcttgcta actcttccag
    24121 ataattatgg tttacgatag agactttatg attgaagttt ccatttgcaa tataacgaat
    24181 ttcttctatc atttttttaa tacaagtttc ataataaatc tttctttcat gacgataaaa
    24241 aatgtatagg taggatgaga aaatagaaaa taaaaacaaa taagatacaa tcatcatcca
    24301 tagagattcc tttattcctt tatatttttc atatccaaaa attctaatga attcttttcc
    24361 gagctcgctt aacgtaagtg aactttcaat tacacttgta acaaggcgat atataattaa
    24421 ttcagtaata ggagtaagtg tgatggctaa cataaaccaa aaaattaact tccattttgg
    24481 gatatctttt aatatatcaa atgcttcatt tctcaatttt atagcctact ccccaaacag
    24541 tatgaataaa cttttctcca ttcattcctg tttcaagttt atctcgtaaa ttactaatgt
    24601 gaaccattac agttttattt gaaccataac catcttcgtt ccatacgcgt tcaaaaattt
    24661 cttcggaact aaatactctt ccggtattac tcgcaagtaa atataaaata tcaaattcaa
    24721 tagatgtaag tttaatatat tctccattta ctttaacagt atgattatgt ttgtgtattt
    24781 cagcagaacg aatacgaata ataccatctt catttttgga ggaagtggca ttttggaaag
    24841 atgatcttcg taacaaagct ttcactctag ctactaattc taatggattg aatggcttaa
    24901 tcatataatc atctgcacct gtcataagac ctaatatttt atccatatct tctgcttttg
    24961 cactcagcat aagaataggt acagtattat tctcacgaac ttcctggcaa acttctaatc
    25021 cattgcgttt tggcatcata atatccaaaa ccataaggtc aacatcatat gtagaaatca
    25081 tttgcaatgc ctcatcgcca tcgtatgctt tataaatgtt atagccttca tttcgcaaat
    25141 aaacagcaag taactcaaca atttctttat catcatcaat aattaatatg tttttattca
    25201 ttatgtagtt cctttcctta caaatcatta acattact
//
