LOCUS       NZ_CP036070            23508 bp    DNA     circular CON 25-JUN-2024
DEFINITION  Bacillus wiedmannii strain JAS07/5 chromosome, complete genome.
ACCESSION   NZ_CP036070
VERSION     NZ_CP036070.1
KEYWORDS    RefSeq.
SOURCE      Bacillus wiedmannii
  ORGANISM  Bacillus wiedmannii
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5239489)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5239489)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (12-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 150.157x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018741285.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 04:17:39
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,980
            CDSs (total)                      :: 5,827
            Genes (coding)                    :: 5,631
            CDSs (with protein)               :: 5,631
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 196
            CDSs (without protein)            :: 196
            Pseudo Genes (ambiguous residues) :: 0 of 196
            Pseudo Genes (frameshifted)       :: 88 of 196
            Pseudo Genes (incomplete)         :: 110 of 196
            Pseudo Genes (internal stop)      :: 59 of 196
            Pseudo Genes (multiple problems)  :: 52 of 196
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:47:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1191906
            Orig. end                         :: 1215414
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036070.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23508
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="1"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23508
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23508
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13508](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13508)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(786..804)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: medium, score: 24.43"
                     /tool="antismash"
     gene            834..1193
                     /locus_tag="EXW41_RS06160"
                     /old_locus_tag="EXW41_06210"
     CDS             834..1193
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016082428.1"
                     /locus_tag="EXW41_RS06160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06210"
                     /product="DUF4029 domain-containing protein"
                     /protein_id="WP_087984759.1"
                     /transl_table=11
                     /translation="MLRRKLLYLLLTVPLYAWLISMTKIEVMALFLGYVFIFSNLNRIQ
                     EQSILEICIFSISIELFSIVSIVLLNELFRWIHSFELMKFGNVVLQVICAYIVFVVLDK
                     IVGQQSVFQDKRKWE"
     gene            1310..2809
                     /locus_tag="EXW41_RS06165"
                     /old_locus_tag="EXW41_06215"
     CDS             1310..2809
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015129 - lactate transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0015727 - lactate transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016094531.1"
                     /locus_tag="EXW41_RS06165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06215"
                     /product="L-lactate permease"
                     /protein_id="WP_088062518.1"
                     /transl_table=11
                     /translation="MAVLLALIPIMMIFICLFLFKQTSLRSSLIAYVVSVGIVLLSPTF
                     QLGISETVHATIKGWLICFIVGYVLFFGIFLFHLMNKMGYIDQVARFLEEVTHDRLLQM
                     LLMCFGICPLIESVSGFGIGFMVAAPIFLSLGYKPFQAVLLSFIGLLASSWGAMATGTI
                     IGSQLINMPLTTLGTNTALLSIPMFAYFVILSLHVVGGWQAVIEKWKEGFGFFLLFSLG
                     IYLSNAYVSVELAGILSSIVTIAFGFLIIKLKGKNEQNLMTEHAAATEREVSIIKIISP
                     YIFLTVCILLSRLVPALHDVFRSYAVLDLKSYSYKLELLYSPGFWLGMTCLFTIIFFRI
                     PSHIIKQSLSQTIKQWIPFAITTTMFITISELMGASGMHSLLAKTAGETFGTFFVFVAP
                     FIGGIGGFLTGSNAGSNAMFIKLQMQTAQNVALPWQYVTTLQNTASSVATIACPSRITL
                     GAYLCNIPYRENELLKKTTLMIFGAVLLVVVEVIFWYLLRK"
     misc_feature    complement(1339..1354)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 22.85"
                     /tool="antismash"
     gene            2901..3584
                     /locus_tag="EXW41_RS06170"
                     /old_locus_tag="EXW41_06220"
     CDS             2901..3584
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001128609.1"
                     /locus_tag="EXW41_RS06170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06220"
                     /product="YukJ family protein"
                     /protein_id="WP_088062520.1"
                     /transl_table=11
                     /translation="MPLKNYGVLKGTVIQSKIGKGKTPHYQVHLQGEAGVDYRIAINVK
                     SQSYPSEVLYFASTDIRSEAIHILPTLPFGFTEVKNNEPKVALDYVRGNVFDSKQMIPL
                     PAEKAGVDNDLNEKIERYIKRAVEEKAIIYAFGERWGPEENTPDSYFHFEPGNGIHDIH
                     MNQGNVEKWKGDNGIWQDGGILIHFEKEEEWIGIFLAFQSQSWCTDEEGHARVPVEHCD
                     YKGNK"
     gene            complement(3599..4432)
                     /locus_tag="EXW41_RS06175"
                     /old_locus_tag="EXW41_06225"
     CDS             complement(3599..4432)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017762920.1"
                     /locus_tag="EXW41_RS06175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06225"
                     /product="hypothetical protein"
                     /protein_id="WP_046958289.1"
                     /transl_table=11
                     /translation="MELVNSIFQILLTSVIQLFSLIGVIIVIGFLLGYLESLTRMYWSR
                     AFGRKGFLLTAWIGVPIHELGHAIMCVLFRHKIVATQFFPTDTSQGALGYVQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILLMRYFVPNSYFLFNTTLEKTIASTSINIEMVQNML
                     LSTFVLLKSLFTISNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVIVMFIVLFLF
                     NIIAGLFQYDSNQLIGKVMKYNMYLIAFSSVALLFSCISTLVSFGFYKIRGGRSF"
     gene            4631..5416
                     /locus_tag="EXW41_RS06180"
                     /old_locus_tag="EXW41_06230"
     CDS             4631..5416
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000650102.1"
                     /locus_tag="EXW41_RS06180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06230"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_088062522.1"
                     /transl_table=11
                     /translation="MKCPACHTENTAEAKFCGNCGHSLTEEAVASGAQEEGEQQARVAP
                     AEETRSNETVEQAKRFASGYFQFFKHALQAPTAIMKSGKVEVRNGIVSLVLICFLGACI
                     FYRMMSAAAAVTKTFAPDISTPTFFLDSVTVFLFLLILTLFVGFIIFVSGKMMKSSFSF
                     LEVFGIWGTIATPVIAILVLSFLFSFLLIFFLPILLGLATTYMGISIIVATVKLDNGGL
                     DLVYTLFIANIFIGIATFIVLWSYISTIIQTFTQGLKGL"
     misc_feature    4657..4677
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 28.31"
                     /tool="antismash"
     gene            5436..6671
                     /locus_tag="EXW41_RS06185"
                     /old_locus_tag="EXW41_06235"
     CDS             5436..6671
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016128956.1"
                     /locus_tag="EXW41_RS06185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06235"
                     /product="YARHG domain-containing protein"
                     /protein_id="WP_088062524.1"
                     /transl_table=11
                     /translation="MNVCTKCGTQLEDGVQFCQSCGRKRESLAVKKKMSSGTKVGITIL
                     TLLAVVIVGLYLYGSSYYKQAAQVDRIITILQERNGEKLAEIVTADDPSVTVTRESLMP
                     LFSYIKENSSYVNELKEQLRIGEKQGNGIERADFSLTKDGKYFFLFDRYKLKAKTYYTT
                     LLTNEKGTSLKMNGKEIDKTDDKKFEKQYGPFLPGTQVFQAEYKNDYVKLSREEKVVLM
                     KQGQNNVTIDLTLQGQYITVQTNVPGATLYVNQKPVTALAGEEITWGPVATDGSATIYL
                     ERNGESGRETTKVETVTALSSYNLPFEKKSAEKTVVYNVTPPPTTRYVYNGFIFPDSDI
                     RKLTSAELTYLSKEQLKIARNEIYARHGNIFQTKDMQAYFSKQSWYRENPYFSGTLTNI
                     ESYNVELIKARE"
     gene            complement(6709..7137)
                     /locus_tag="EXW41_RS06190"
                     /old_locus_tag="EXW41_06240"
     CDS             complement(6709..7137)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001978351.1"
                     /locus_tag="EXW41_RS06190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06240"
                     /product="hypothetical protein"
                     /protein_id="WP_088062526.1"
                     /transl_table=11
                     /translation="MCAGLLAQTPEEPQEPKPAVSLDQEFSINATLYSARAWLSNDETF
                     AQTIWKGSHFASASHAGKSILPIGTVKILNLSDDTITVTASSESDDALKIVVPPHSEGV
                     LTSSALSDVQASTSGGASKVTFLFHIFFSRDPGSAKKP"
     gene            7337..8671
                     /locus_tag="EXW41_RS06195"
                     /old_locus_tag="EXW41_06245"
     CDS             7337..8671
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="EXW41_RS06195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06245"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_079245213.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-64, bitscore:
                     216.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDENATVVTLEKGEIYSYAQCGLP
                     YVISGAIASTEKLIARNVKTFRDKYGIDAKVRHEVTKVDTEKKVVYAEHTKTKDIFEFP
                     YDRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVEDVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEYIHKEADKHNIEILTNENVKAFKGNER
                     VEQIETDKGTYKADLVLVSVGVKPNTDFLEGTNIRTNYKGAIEVNAYMQTNVQDVYAAG
                     DCATHYHVIKEIHDHIPLGTTANKQGRLAGLNMLDKRRAFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAKPLYLKLLYRSDTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            8772..9260
                     /locus_tag="EXW41_RS06200"
                     /old_locus_tag="EXW41_06250"
     CDS             8772..9260
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135035.1"
                     /locus_tag="EXW41_RS06200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06250"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_088062528.1"
                     /transl_table=11
                     /translation="MFVTLQTVQESEKEILRNLYALYLHDLSTFTPNIKIGANGFFEYE
                     DLYMFWENDGITPYFIKSNNDIVGFLLLLERPFLKKENDFCINDIFILNQYKGKGIGKQ
                     VIENVLKEKRGQYFVIELVKNVPAVSFWKKVYRELNIEFDEKTQLINDEECLVQTFKI"
     gene            9560..9970
                     /locus_tag="EXW41_RS06205"
                     /old_locus_tag="EXW41_06255"
     CDS             9560..9970
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="EXW41_RS06205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06255"
                     /product="DUF3908 family protein"
                     /protein_id="WP_000996802.1"
                     /transl_table=11
                     /translation="MAINMKTIEEWIAESNARQEEDFGNVVEEMKEVCVGLDNATLIYT
                     KNVFCFGKKVEVLFFFQDHVVIGQEKDEYVEIEKLKYEAITHSNLKTNDKNTTLELKFA
                     NGQSINLDSLNDNYGTKNWLFARQIKSIFKLI"
     gene            complement(10001..11542)
                     /locus_tag="EXW41_RS06210"
                     /old_locus_tag="EXW41_06260"
     CDS             complement(10001..11542)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716912.1"
                     /locus_tag="EXW41_RS06210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06260"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_088062529.1"
                     /sec_met_domain="PF00881 (E-value: 1.3e-08, bitscore: 33.3,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLDTFLHHLHFSIDEIMPNHEVDWEDAPLPYKLYRNVPIIPLSL
                     EIPLSLPNSSTTPTLKEIGHYLWSSFGLTQLCQLNSEKILFRRSIPSGGALYPNELYIY
                     LKIDDYPDGIYHYDAAHHRLILLREGNFDSYITEALGNRCNIQSCFGAAFVSTMFWKNY
                     FKYNNFSYRLQGLDSGVLIGQLLACAKQFGYTNGVYFQFLDRAINHLLGLSEGEESVYA
                     VVPLSTEPQTNWFHNDYRENKTVTSHELLQQIPPLAHEHFVRSKHVNEYPMLTKINEAS
                     MIESTAHFQTLHHEEHYQHHAHAVQLPQVERLSYDFLQLCKERYSPDADFTFTKWDTAE
                     LATLLQEASLSFPYYNDLDGQYVNENARVSLYGCFYNVKDIENGAYSYNSKTHSIQPLR
                     YGDLRYPLQSSMTMDNVNLFQVPLCLHVVGKKDYYTNALGYRGYRIHQMEAGILVHKLV
                     FAATAMGMGGHPLLSFNTNSCDQLYGIDTGNETSLIQIPVGAYRARNWLKGDLRN"
     gene            complement(11559..13508)
                     /locus_tag="EXW41_RS06215"
                     /old_locus_tag="EXW41_06265"
     CDS             complement(11559..13508)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="EXW41_RS06215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06265"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_087984771.1"
                     /sec_met_domain="YcaO (E-value: 1.1e-86, bitscore: 289.9,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 7.7e-143, bitscore:
                     474.1, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQNILLIGDGLLANYVHDQLCKQYSIIRQHNLTEELPENIHLAL
                     VLHDGSPSTIHHDAELMFRSNHIPWLRAFTSFGEGIIGPYIHPLATGCSNCSDGRRFIA
                     GFDQQEMWALQRKYALKADNVTRRDVRATQNGMLQMCHLIRAETEKILTHNHSSLENEL
                     ILLNLQTLQCTRHSFLPDPLCPVCSNLPDDTADAAAISLQPSLKTSEAAYRCRSIHELN
                     TFLTRDYLDYRVGMLNGKMQHSLLPFADVIINMPLMFGNEGVAGRTHSFAMSEATAILE
                     GLERYCGMSPRGKKTNVHGSFRELEDHALNPLLLGVHTNEHYNRNSFPFKPFDPDYEQN
                     WVWGYSLLQNRPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIQRLYTITGYELHAFNATMEHGIPSLWVIAK
                     NTRENGMNVVCAGGSHLDPVRALKSAIHEIAGMLLIADDELEQKREHYENCLQDPYLVN
                     KMEDHSMLYGLKEAEERLHFLLRDDAPVQSFQEMNALQSVDLDLTSDLHQLLNRLQQSG
                     LDVIVVDQTVPLIEKNGLHCVKVIIPGMLPMTFGHHLIRVTGLDRVYTVPMTLGYTNEP
                     LTNEQLNPHPHPFP"
     gene            complement(13505..15424)
                     /locus_tag="EXW41_RS06220"
                     /old_locus_tag="EXW41_06270"
     CDS             complement(13505..15424)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="EXW41_RS06220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06270"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_088062531.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1251.7,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     9.4e-55, bitscore: 180.9, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 7.2e-11,
                     bitscore: 40.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPIDAKLKANKDTFFLPDSNGGVYFRNNASSFRMDGDGIYNW
                     IEKLMPMFNGNYSLAEITDGLPLPYQNRVFEIGEILYENGFVRDVSQDAPHELNSALLD
                     RYASQIEFLEADSHSGALKFETYRAANVLIIGSGDMLTSLVSSLLESGLPTFHYLVTDY
                     EETNYDRIHELVELAHEVDDHVLVQEIDTTIDRPLHEVFEPFDWILYVSQNGDIEGLRA
                     VHTICREVGKNFIPAVCLSALGIAGPIVTANREECWESAWHRLHETTLQNEHSSASFSP
                     LPSAMLANIIVFELLKHVADDSYREKEPQFFLLNYETLEGAWHPFIKHPLATDESFTID
                     TIENLSEQLEQRSNQHTSTDLFRFFDSLTSKEAGLFHVWDEQDSYQLPLSQCHIQVATP
                     LSDGPASLLPLMTCGGLTHNEARREAGLAGIETYVAEIMHRLIPEHNDIGIGAGETMTE
                     GVYRALQQHLNNKLYERQSHMLEEITTIDLTAIHDKHCRFYYDALSTIHEPPKIAMSEE
                     ILSFPVVWVGINDRWYGASNINMTLALRNALQLSLLHIQNEETPYRANILPESSIILYD
                     TDSFRVEIQAEEEVPGVQSVQLALQHLEEHNFYPFVFDLAIESFLKENLDGVYGVLIAK
                     EDSL"
     aSDomain        complement(15125..15424)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EXW41_RS06220_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="5.00E-57"
                     /identifier="RREFam011.1"
                     /label="EXW41_RS06220"
                     /locus_tag="EXW41_RS06220"
                     /protein_end="100"
                     /protein_start="0"
                     /score="180.9"
                     /tool="antismash"
                     /translation="MNNLPIDAKLKANKDTFFLPDSNGGVYFRNNASSFRMDGDGIYNW
                     IEKLMPMFNGNYSLAEITDGLPLPYQNRVFEIGEILYENGFVRDVSQDAPHELNS"
     aSDomain        complement(15158..15394)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EXW41_RS06220_Thiopeptide_F_RRE.1"
                     /evalue="3.90E-13"
                     /identifier="RREFam004.1"
                     /label="EXW41_RS06220"
                     /locus_tag="EXW41_RS06220"
                     /protein_end="89"
                     /protein_start="10"
                     /score="40.2"
                     /tool="antismash"
                     /translation="KANKDTFFLPDSNGGVYFRNNASSFRMDGDGIYNWIEKLMPMFNG
                     NYSLAEITDGLPLPYQNRVFEIGEILYENGFVRD"
     gene            complement(15550..16809)
                     /gene="odhB"
                     /locus_tag="EXW41_RS06225"
                     /old_locus_tag="EXW41_06275"
     CDS             complement(15550..16809)
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="EXW41_RS06225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06275"
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_000569906.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPAAEQPKQETTEAPKA
                     AAPNAEQTTTLQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVD
                     MTAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYD
                     IGIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGMKARDNKLSLKELQGGTFTITNGG
                     VFGSLMSTPILNSPQVGILGMHKIQVRPVAIDAERMENRPMMYIALSYDHRIVDGKEAV
                     SFLVAVKDMLEDPKSLLLEG"
     gene            complement(16942..19809)
                     /gene="odhA"
                     /locus_tag="EXW41_RS06230"
                     /old_locus_tag="EXW41_06280"
     CDS             complement(16942..19809)
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="EXW41_RS06230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06280"
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_088062533.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAA
                     NGQSLLEKAMNELSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPVLDEIVLEGAKGGVEDVMIGMAHRGRLSVLAHVLEKPYSHMFAEFKHAKIEGAV
                     ANSGWTGDVKYHLGREQVVSNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPEQDTSKSFVILVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRILFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEVETMTQFIQEQLKSDYA
                     QVPPADTSAATIDVKVPDVVAKGIQPIDTGVEIDSLRAINEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTDAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGM
                     KPTKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIIKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDKVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKQEIEVFSN"
     gene            20632..20841
                     /locus_tag="EXW41_RS06235"
                     /old_locus_tag="EXW41_06285"
     CDS             20632..20841
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428510.1"
                     /locus_tag="EXW41_RS06235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06285"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000428506.1"
                     /transl_table=11
                     /translation="MENKMVEYRKKFGLSQEKLAEKLGVSRQTIISIEKGKYDPSLPLA
                     FEIAKTFQTTIEHVFIYEGKEEGE"
     gene            20844..21221
                     /locus_tag="EXW41_RS06240"
                     /old_locus_tag="EXW41_06290"
     CDS             20844..21221
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016101524.1"
                     /locus_tag="EXW41_RS06240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06290"
                     /product="permease"
                     /protein_id="WP_088062535.1"
                     /transl_table=11
                     /translation="MNYSQKYFLIMGIIFFIMSGTMVLAGIMTHSAPPAPTYTVLTMMI
                     MCFCLSYLHPQFKEKDERMKLIRYKGMFFSFFALTAYYLLFSFGLNLHVITLSAVELLN
                     ILMALTMSTVFISFVVLSKRY"
     gene            21250..21432
                     /locus_tag="EXW41_RS06245"
                     /old_locus_tag="EXW41_06295"
     CDS             21250..21432
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="EXW41_RS06245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06295"
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_001178300.1"
                     /transl_table=11
                     /translation="MQMMYAFGIGLVLFLAVFLFIRKDVQGGTLTKRGFYKMIGCLVVM
                     FIAIIVMIVLINQSL"
     gene            21567..21926
                     /locus_tag="EXW41_RS06250"
                     /old_locus_tag="EXW41_06300"
     CDS             21567..21926
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001036563.1"
                     /locus_tag="EXW41_RS06250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06300"
                     /product="hypothetical protein"
                     /protein_id="WP_088062537.1"
                     /transl_table=11
                     /translation="MNKKTIFFLLTCLLLIASITYIICNKREQVPPMLVWEHQEYYVTN
                     EPAEAEKVGQRLGEVTKKIETSKKPTKNSESNIVQEKTEVFTMIEEEKNPHSSLIIKEP
                     YSDEYRVVRPMLHVL"
     gene            21945..22211
                     /locus_tag="EXW41_RS06255"
                     /old_locus_tag="EXW41_06305"
     CDS             21945..22211
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002158817.1"
                     /locus_tag="EXW41_RS06255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06305"
                     /product="hypothetical protein"
                     /protein_id="WP_142291692.1"
                     /transl_table=11
                     /translation="MQTVTYPWSLRKMFVFFLCFILPPIGAIYILMNREALQKRDFILY
                     VLFAAINISLWLSLMILDRSVWMVAGHYVFGAIVIVFSNMNKR"
     gene            22431..23027
                     /locus_tag="EXW41_RS06260"
                     /old_locus_tag="EXW41_06310"
     CDS             22431..23027
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002126039.1"
                     /locus_tag="EXW41_RS06260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW41_06310"
                     /product="hypothetical protein"
                     /protein_id="WP_141542783.1"
                     /transl_table=11
                     /translation="MQKIKKLLLLMMVVGLTVGVLAGCANPKDTTEEFLTAIQKGDIEK
                     ARTFVESDKEFNKLNEKTDDAEAKAMLSAITKNFKFEKLEEVSKKDDKAEVKVKITSAD
                     LSVAVTKAVGEVMPMAFASAFSEDKEQSEKAIEKTMTSAIVKHLSDKDAIMATREVTLN
                     LKKNKDGDYKIVADDNLKEVLFANAKSLEKMFRGK"
     misc_feature    complement(23251..23266)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
ORIGIN
        1 aaagcagcgt ttgaaaatgg taagaaagca tttattccgt acgtaatggg cggagatggt
       61 ggccttgaaa aattaaaaga aagaatttgt tttctagacg aagcaggagc aagtatcgtt
      121 gaaatcggta ttccgttttc agatccagtc gcagacggtc caacgattca aagagcaggg
      181 aaacgagcgc tagatagcgg tgtaacatta aaaggcattt ttcaagcatt aatagaggta
      241 aggaaaaaag tacaaattcc gtttgtactc atgacatatt taaatccagt actcgcattc
      301 ggaaaagaac gattcatcga aaactgtata gaagcaggtg tagacggtat gatcgttccg
      361 gatttaccgt atgaagaaca aaatattatt gccccgttac ttcgagaggc aaacattgcg
      421 ctaattccac tcgttacagt aacgagccca attgagcgaa ttgaaaaaat tacgagtgaa
      481 tcagaagggt tcgtttacgc tgttacagta gcgggcgtaa caggagtaca tcaaaacttt
      541 aaaggtgaga ttcatagtta cttagaaaaa gtaaaatcac atacacattt accggtagtg
      601 gcagggttcg gtatttcaac gaaggaacat gtagaagaaa tgattacaat atgtgatgga
      661 gtagtcgttg gaagtaaagt tatcgagctg ttagaaaatg aaaaacgaga agaaatatgt
      721 gaattaatac aggcaacaaa acaaaaagaa gaggcataag tctcttcttt ttgttttacg
      781 taataaatgt taaaatatac agaaaataca tataacttag agggtgagaa agcatgctaa
      841 gacggaaact actatatctt cttctaactg taccattata cgcttggctc attagcatga
      901 cgaaaataga ggtgatggct ctatttttag gatatgtatt catcttttcc aacttaaatc
      961 gcattcaaga gcaatctatt ttagaaatat gtatattttc gattagtata gaactattta
     1021 gtatcgtttc gattgtatta ttaaacgaat tatttcgctg gatccattca tttgaattaa
     1081 tgaaatttgg aaatgttgta ttgcaagtaa tatgtgctta tattgtgttt gttgtattag
     1141 acaaaatagt tggacagcag agcgtttttc aggataaaag aaaatgggag tgattcaaaa
     1201 aaggagctaa atggctcctt ttttgaatct gtagtaaaaa caattgaaaa ttatgatatc
     1261 tgttatataa tagttaaaaa ttgtattttt aatgaaaaga gatgataaca tggccgtatt
     1321 gttggcactt atcccaatta tgatgatttt catttgttta tttttattta aacaaacgtc
     1381 attaaggtcc tctttaattg cttacgttgt gtctgttgga atcgttttac tctcgccaac
     1441 gtttcaacta gggataagtg aaactgtgca cgcaacgatt aaaggttggt taatttgttt
     1501 tattgtcggg tacgtgttgt ttttcggtat ttttttattt cacctcatga acaaaatggg
     1561 gtacatcgat caagtagcac gttttctaga agaagtgacg cacgatcgtt tattacaaat
     1621 gctccttatg tgttttggta tttgtccgct aatcgaatca gtaagtggat tcggaattgg
     1681 cttcatggtt gcagcaccta tctttctatc attaggctat aaaccgtttc aagctgtact
     1741 actttcattt attggtttac tagctagttc atggggcgca atggcaactg gtacgattat
     1801 cggttcgcag cttataaata tgccgcttac aacacttggc acaaatacgg cactactaag
     1861 cattccgatg tttgcttatt tcgtcatcct ttctttacac gttgttggtg gttggcaggc
     1921 tgttattgaa aagtggaaag aaggattcgg tttctttcta ttattttctc tcggaatcta
     1981 tctttctaac gcatacgtaa gtgttgaact agcaggtata ttaagttcca tcgttacaat
     2041 tgcatttggc tttcttatca ttaaattaaa agggaaaaat gaacaaaatt taatgacaga
     2101 acatgctgcg gcaacggaga gagaagtatc tattataaaa attattagcc cttatatatt
     2161 cctaacagtt tgtattttac tttctcgcct cgtaccagca ttacatgatg tattcagatc
     2221 atatgcagtc cttgatttaa aatcatactc ttataaactg gagctactat attcaccagg
     2281 attttggctc ggtatgactt gcttatttac tattattttc ttccgcattc catctcatat
     2341 tattaaacaa tcactctcgc aaacgataaa acaatggatt ccttttgcga ttacaacgac
     2401 aatgtttatc accatttcag aactaatggg tgcatctggc atgcattcat tactggcaaa
     2461 aacagctggt gaaacatttg gaacattttt cgttttcgtt gctccgttta tcggcggaat
     2521 cggtggcttt ttaacaggta gtaacgcagg atcaaatgcg atgttcataa aactacaaat
     2581 gcaaactgcg caaaacgtag cactcccttg gcaatacgtt acaacactgc aaaacaccgc
     2641 atcatcagta gcgacaatcg cttgcccgtc acggattacg ttaggtgctt atttatgtaa
     2701 tataccgtat cgtgaaaatg aactattaaa gaagacgacg ttaatgattt ttggtgcggt
     2761 gttgcttgta gtggtagagg ttattttttg gtatctgttg agaaaataag aaatcctcct
     2821 gagaaaggag gattttcttt ttatatggat aatgccttaa gtatgaaaag cttctactaa
     2881 atgaatagga gatgaaatgt atgcccctaa aaaactacgg cgtgttaaaa ggtacagtta
     2941 tacaatcaaa gattggaaaa gggaaaacac ctcattatca agttcattta caaggcgaag
     3001 caggagtaga ttatcgtatt gcaattaacg tgaaatcgca aagttatccg tcagaggttt
     3061 tatattttgc gagtaccgat attcggtcag aggcgattca cattttaccg acattaccat
     3121 tcggttttac agaagttaaa aacaatgagc cgaaagtagc tttagactac gtaagaggta
     3181 atgtatttga ttcgaagcaa atgattcctt taccagctga aaaagcagga gtggataatg
     3241 atttaaatga aaaaatagag cgttatataa aacgagcggt agaagaaaaa gcaattattt
     3301 atgcgttcgg tgaaagatgg ggaccagaag aaaatacacc tgattcttac tttcatttcg
     3361 agccaggaaa cggtatacac gatattcata tgaatcaagg gaatgtagag aaatggaaag
     3421 gtgataatgg tatatggcaa gacgggggaa tacttattca ctttgaaaag gaagaagaat
     3481 ggatcggtat ctttcttgcc ttccaatcac agtcatggtg tactgatgaa gaaggacatg
     3541 ctcgtgttcc ggttgagcat tgtgattata agggaaataa atgatgagag gagggcgttc
     3601 aaaacgaacg ccctcctctt attttataaa acccaaaact aacaagtgta gaaatacaag
     3661 agaacagcag agccacacta gaaaacgcaa tgaggtacat attatacttc atcacttttc
     3721 caatgagctg gttactgtcg tactgaaata gtcctgctat tatgttgaat aaaaataata
     3781 cgataaacat gacgataaca ccgtctattg atcctttaat atctggttta cttaaagcga
     3841 tatgtgcaga aatacaaatg gcgataaata aaaataacca aaaagaagga tttaataaat
     3901 tacttattgt aaataagctt ttcaataata caaacgtcga taaaagcatg ttttgaacca
     3961 tttctatatt aatagaagta gaagcgattg ttttttcgag ggttgtatta aataagaaat
     4021 atgaatttgg tacgaaatag cgcattaaaa ggattaacgc agtaataccg gaaataatag
     4081 gaccgattcc aatgaagaag ttcccaattc gttgatatac acttttttga ttgtattgat
     4141 gttgtacgta gcctaaagca ccttggcttg tatctgttgg gaaaaactgc gttgctacaa
     4201 ttttatgacg aaatagtaca cacataatgg catgtccaag ttcatgaata ggaacaccaa
     4261 tccacgccgt taaaaggaat ccttttcttc cgaaagctct cgaccaatac atgcgtgtga
     4321 gagattctaa ataacctaat agaaatccaa ttacaatgat aacgccaatt aaagaaaata
     4381 attggattac gcttgtaagg agtatttgaa aaattgagtt tactaattcc attaccagtc
     4441 atccaatctg ttaaaaatgt tatttgttct gtttcataat agcattattt ttcaagattg
     4501 ctagcacata tattttcatt tgaaagaagg atttcataat ctttttcttg tagtcatgtt
     4561 ttatgtacaa agtcatatat tgaatttgta acaccctata tggtatctgc ttaagggggg
     4621 ggatgcgata atgaaatgtc cggcgtgtca tacggaaaat acagcagagg caaaattttg
     4681 cgggaattgt ggacattcgt tgacggagga agccgtagcg agtggtgcac aggaggaagg
     4741 tgagcaacaa gcacgcgtag caccagcaga ggaaactcga tcaaatgaaa cggtagagca
     4801 agcgaagcgg tttgcaagtg gctactttca gttttttaaa cacgcattac aagcaccgac
     4861 agctattatg aaaagtggca aggttgaagt acgaaatgga attgtaagtc ttgttcttat
     4921 ttgtttttta ggggcatgta ttttttatag aatgatgagt gctgcagcag ctgttacgaa
     4981 aacatttgca ccagatatat ctactcctac attctttttg gactctgtaa cggtcttttt
     5041 atttttactt attttaactt tatttgtcgg atttattatt tttgtcagtg ggaagatgat
     5101 gaaatcatct ttttcgtttc ttgaagtatt tggaatatgg ggaacgatag caactccggt
     5161 aattgctata ttagtgcttt cttttctgtt tagcttttta ttaatctttt tcttaccaat
     5221 tttattaggg ctggctacaa catatatggg aattagtata attgtagcta cagtaaaact
     5281 agataacggt ggattagatc ttgtttacac tctttttatc gcaaatattt tcattggaat
     5341 tgcaacattc attgtactgt ggtcttacat tagcacgata attcaaacct ttacacaggg
     5401 attaaagggc ctctaaagaa aaggtggttg aatggatgaa tgtatgtaca aagtgtggga
     5461 ctcagcttga agatggtgtg caattttgtc aaagctgcgg gaggaagagg gagagtcttg
     5521 cagtaaagaa gaaaatgagc agcggtacaa aggttggcat tacaatttta acattacttg
     5581 ctgtagtgat tgttggactg tatttgtacg gatcatcgta ttataagcag gcggcacaag
     5641 tagatcggat cattactatt ttacaagaga ggaacgggga gaagttagct gaaatcgtca
     5701 cggcagatga tccatcagtt actgtaacga gagagagtct aatgccacta ttttcgtata
     5761 taaaagaaaa ttcatcttat gtgaatgaat tgaaagaaca gttgaggata ggtgaaaaac
     5821 aagggaacgg aatcgaaaga gcagactttt cgttaacgaa agacggaaag tatttctttt
     5881 tatttgatcg gtataaattg aaagcgaaga cgtattatac gacattgctt acaaatgaaa
     5941 aaggtacatc tttaaaaatg aacggaaaag aaatagataa aacagatgac aaaaagtttg
     6001 agaagcaata tggaccgttt cttccaggaa ctcaagtgtt tcaagcagaa tataaaaatg
     6061 attatgtgaa actatcacgt gaagaaaagg ttgtacttat gaaacaaggt caaaataacg
     6121 taacgataga tttaacgttg caaggacaat atattacggt tcaaacgaac gtgcctggtg
     6181 caacattgta tgtgaatcaa aaaccagtta cagcgctggc aggagaagaa attacatggg
     6241 ggcctgtagc aactgatgga agtgcgacga tttatttaga acgaaatgga gaaagtggaa
     6301 gggaaacgac aaaggtagaa acggtaacgg cactttcgtc ttataatctt ccattcgaaa
     6361 agaaaagtgc ggaaaaaaca gttgtttaca atgttactcc gccgcctacg actcggtatg
     6421 tatataatgg tttcatcttc ccggatagtg atattcgaaa actaacgagt gcagaattaa
     6481 catatttatc gaaagaacag ttgaaaattg ctagaaatga aatatacgca agacatggaa
     6541 atatttttca aacgaaagat atgcaagcgt acttttcaaa acagtcttgg tatagagaaa
     6601 atccgtattt ttcaggaacg ttaaccaata ttgaatccta taatgtggaa ctgattaaag
     6661 caagagaata aacatgtgaa aaaggtacag tgcatagctg taccttttct atggtttttt
     6721 agctgaacca ggatcccttg aaaaaaagat atgaaagagg aatgtgactt tacttgctcc
     6781 tcctgatgta cttgcttgca catcagataa tgcactagat gttaacacac cttcagaatg
     6841 aggcggtacc actattttga gggcatcatc tgattctgat gatgcagtaa ctgttattgt
     6901 atcatcagat aagtttaaaa tttttacagt accgattggt aagatagact tgccagcgtg
     6961 tgatgctgaa gcgaagtgag agcctttcca aatcgtttgt gcgaaggttt catcattaga
     7021 taaccaagcg cgagcgctgt ataatgttgc gttaatggaa aattcttggt caagtgacac
     7081 ggcgggtttc ggttcttgcg gttcctctgg agtttgagcg agaaggccgg cacacatata
     7141 tgtttcacct actttcgata gttactgtta tagcatatta aacatgttat ttataagaca
     7201 cgacggctac ctattcaggc ataggtttgt gcaccaaatt tgaagatgaa attatctttc
     7261 tttacaatgg aagtaggtgt tatttctgaa aaatatggaa aacgtaaaga gtatgtagaa
     7321 aagaaggagt ggtaaagtga actatgtcat tattggcgga gatgcagctg gtatgagcgc
     7381 agctatgcaa attgttagaa acgatgaaaa tgcaactgtt gtaacgttag aaaaaggtga
     7441 aatttattcg tacgcgcagt gtgggttacc atatgtcatt agtggtgcta tcgcttcaac
     7501 ggaaaaatta attgcgcgta atgtgaagac gtttcgtgat aaatacggaa ttgatgcgaa
     7561 agtacgacat gaagtaacga aagtagatac ggaaaagaaa gtggtgtacg cagagcatac
     7621 gaagacgaaa gatatttttg aatttccgta cgatcgttta ttaattgcaa ctggcgtacg
     7681 tcctgttatg ccagagtggg aaggtcgaga tttgcaaggc gttcatcttt taaaaacaat
     7741 tccagatgct gagcgtatat taaaaacgct agaaacgaat aaagttgaag atgtaaccat
     7801 tattggcggt ggtgcgattg gactggagat ggcagaaaca ttcgtcgaac ttggtaagaa
     7861 agtaagaatg attgagcgaa atgatcatat cggtacgatt tatgatgcag atatggctga
     7921 atatatacat aaagaagcag ataaacacaa tattgaaatt ttaacgaatg aaaatgtgaa
     7981 agcatttaaa ggaaatgaaa gagtggaaca aattgaaacg gataaaggta cgtataaagc
     8041 agatcttgtt ttagtatcgg ttggagtgaa gccgaatact gattttcttg aaggaacaaa
     8101 tatacgtaca aattataaag gggcaatcga agtaaatgca tatatgcaaa cgaatgtgca
     8161 ggacgtatat gcagctggtg attgcgcaac acattaccat gttataaagg aaattcatga
     8221 tcatatcccg ctcggaacga ctgccaataa acaagggcga cttgctggac tgaatatgct
     8281 tgataaacga agagcattta aaggtacgtt aggtacaggt attattaaat ttatggattt
     8341 gacgcttgca agaacaggtt taaatgaaaa agaagcaaaa gggctacata ttccgtataa
     8401 aacagtcaaa gtagactcca caaatatggc gggctattat cctaatgcga aaccacttta
     8461 cttgaaatta ttatatcgtt ctgacacgaa acaattatta ggtggacaag taattggaga
     8521 agaaggtgta gataaacgaa ttgatgtgat cgcaatggca cttttcaata aaatgagcat
     8581 tcacgattta gaagatgtcg acttaagtta cgcaccacca tataacagcg tttgggatcc
     8641 aattcagcaa gcggcaagga gagcagaata gcacttttta agtgctattt ttttcgttaa
     8701 aggggaatca ttatttttgg cgaaagaagc gaattggaaa tagttatata tagggaaggg
     8761 gatcattaaa aatgtttgta acacttcaaa cagttcaaga atcagaaaaa gaaatattac
     8821 gtaatttata tgcactatat cttcatgacc tctctacatt cactcctaat ataaagattg
     8881 gggcaaatgg attttttgaa tacgaagatt tgtacatgtt ttgggaaaat gacggaatca
     8941 ctccgtattt tattaaaagt aataatgata ttgtaggatt tttattacta ctggaacgtc
     9001 catttttgaa aaaagaaaat gacttttgta ttaatgacat tttcatattg aatcagtaca
     9061 agggaaaagg aatcggtaaa caagttattg agaatgtact aaaagagaaa cgaggacaat
     9121 atttcgttat cgaacttgtg aaaaatgtac cagctgtttc tttttggaag aaagtatata
     9181 gggagctaaa catcgaattt gatgaaaaaa cacagttaat caatgatgaa gaatgtctcg
     9241 ttcaaacgtt taaaatataa tgaaatcggt gcctctagta gattaatttg aaatttaact
     9301 ttatcctgca ttaacgggca gtaagacccc cacctcaaaa ttcagcgaaa gcaaagaagc
     9361 taagtggggg gcgggctgct cgtaaaagcc cgattggtga aggctgataa tcagtggggg
     9421 atgaagaaaa cccccactaa ttaaagtttc attttatttc gaatataccg ttcgcccttg
     9481 aaaacatagt acttatcgct tatattttca tatagtattt attttttaat aaagcaatga
     9541 tcgaaccagg gggcacagta tggcaattaa catgaaaaca atcgaagaat ggattgctga
     9601 atcaaacgca agacaagaag aagactttgg aaacgttgtt gaagaaatga aagaagtatg
     9661 cgtcggactt gataatgcga cattaattta tacgaaaaat gtattttgtt tcggtaagaa
     9721 agtagaagta ttgttcttct tccaagatca tgtcgtgatt ggacaagaaa aagatgaata
     9781 tgttgaaatc gaaaaattaa agtatgaagc aattacacat agcaacttaa aaacaaatga
     9841 caaaaataca acgttagaat taaagtttgc taacggacaa tctatcaatt tagatagttt
     9901 aaatgataac tacggtacga aaaattggtt attcgcgaga caaattaaga gtatttttaa
     9961 attaatctag taaaaaagca cgccgtccac cggcgtgctt ctaattacgc aaatcccctt
    10021 ttaaccaatt ccgcgctcga tacgccccaa caggaatttg aatgagagac gtttcatttc
    10081 cagtatctat cccgtataac tgatcacatg aatttgtatt aaaacttagt aatggatgcc
    10141 cgcccatccc catcgcggtt gcggcgaaaa cgagtttatg aacgagtatg ccagcttcca
    10201 tttggtgaat acggtatcct ctatagccta atgcatttgt atagtaatct ttctttccga
    10261 ctacatgtag gcaaagcggt acttgaaaaa gatttacgtt atccatcgtc atactggatt
    10321 gaaggggata acgaaggtct ccatatcgaa gtggctgtat ggaatgtgtt ttactgttat
    10381 aagaataagc accgttctct atatctttta cgttataaaa acatccatat aatgagaccc
    10441 gtgcattttc atttacatac tgaccatcaa ggtcgttgta ataagggaag gagagactcg
    10501 cttcttgtag taaagtagcg agctcggctg tatcccattt cgtgaaagta aagtcagcat
    10561 caggggaata ccgttcttta caaagttgta agaaatcata cgataaccgt tctacttgcg
    10621 gcaactgtac agcgtgcgca tgatgttgat agtgctcttc atgatgtagt gtttggaagt
    10681 gtgctgtcga ttcaatcata gaagcttcat tgatttttgt taacattgga tattcattta
    10741 catgttttga gcgaacgaaa tgttcgtgtg ctaacggcgg aatttgctgt aacaactcat
    10801 gagaagtaac tgttttattt tcacggtaat cattgtgaaa ccaattcgtt tgcggttctg
    10861 tacttaaagg aacgacagca tacacacttt cttcgccttc tgacagtccg agtaaatgat
    10921 tgattgcacg gtctagaaac tgaaagtata cgccatttgt gtaaccgaat tgtttggcac
    10981 atgcaagtaa ttgtccgatg agaacaccac tatctaatcc ttgaagtcga tacgaaaaat
    11041 tattgtattt aaagtagttt ttccaaaaca tagtggatac gaatgcagcg ccaaaacaag
    11101 actgtatgtt acaacggttg ccaagtgctt ctgtaatgta agaatcgaaa tttccttcgc
    11161 gaagtaaaat aagtcggtgg tgcgcagcgt cgtaatggta aataccgtct ggataatcat
    11221 cgatctttaa atatatatac aattcatttg gatataaagc gccgcctgaa gggatagatc
    11281 ttcggaataa aattttttcg ctatttagct gacataactg tgttaaacca aatgaggacc
    11341 aaaggtaatg accaatctcc ttcaaagtag gtgtagtaga agagttaggt aaagataatg
    11401 ggatttctaa agagagagga atgataggta catttcggta taatttataa ggaagcggtg
    11461 catcttccca gtccacttca tgattcggca taatttcatc gatagaaaaa tggagatgat
    11521 gtaaaaaagt atccagctgc ataaaatccc ctcctttact atggaaacgg atgcggatgt
    11581 ggatttaatt gttcattcgt taaaggttcg tttgtatatc caagtgtcat cggcacagta
    11641 tatactctat ccagtcctgt aactcgaatg agatggtgac cgaacgtcat cggtaacatg
    11701 cctggaataa tgacttttac gcaatgtaat ccgttttttt ctataagagg tactgtttga
    11761 tctacaacga ttacgtcaag tccagattgc tgcaggcggt ttaaaagttg atgaagatcg
    11821 gatgttaaat ctagatcaac tgattgtaat gcattcattt cttggaacga ttgcaccggg
    11881 gcatcgtcac gtaaaagaaa gtgaagacgt tcttctgctt cttttaatcc gtacagcata
    11941 ctatggtctt ccattttatt tacgagataa gggtcttgta agcagttttc gtagtgctct
    12001 cttttttgtt cgagttcatc gtctgctatt agtaacatgc ctgctatttc atggatggca
    12061 ctctttaaag cgcggacagg gtctaaatga gagcctcccg cacaaacaac gttcattcca
    12121 ttttcacgcg tatttttcgc aattacccat aagcttggga taccgtgttc catcgttgcg
    12181 ttaaaagcat gtaattcata cccagtaatc gtgtacagcc gctgaatcat taattgtaat
    12241 tccgtatcat ttgctgaact aagatcaagg cgagggagag gtaattcggc ataccaagtg
    12301 agcaaaaagg cgtcacgctc tacaatttct aaaatgccat gaaaaattgc ttcttctaaa
    12361 ctaccaccaa ttgcacatcc atttgatgtt tcatacacga aagcatctcg atgaccgagg
    12421 ctataataag caattgattc aggaactaaa agtggccggt tttgtaataa agagtagccc
    12481 catacccagt tttgttcata gtcaggatca aacggtttaa acggaaaact attacgatta
    12541 taatgttcat ttgtatgtac accgagcaag aggggattaa gtgcatgatc ctctaactca
    12601 cgaaaactgc cgtgtacatt tgtctttttt cctcgaggtg acataccaca atatcgttct
    12661 aaaccttcta aaatagcagt cgcttcactc attgcaaatg aatgagttcg gcctgcaaca
    12721 ccttcatttc caaacattaa tggcatgttt ataataacgt cagcaaatgg taataaagaa
    12781 tgctgcattt ttccgttcaa cataccgacg cgataatcta aataatctct cgttaaaaat
    12841 gtgtttagtt catgaatgga acgacagcga tatgctgctt cgcttgtttt taagctcggt
    12901 tgtaacgaaa tcgctgctgc atctgccgta tcatcaggca aattgctaca tacagggcag
    12961 agcggatcgg gaagaaaaga atgccgcgta cattgcagtg tttgtaagtt tagtaaaatg
    13021 agttcatttt ctaaagaaga atggttatga gttaatattt tctctgtttc tgcacgaata
    13081 agatggcaca tttgtaacat accattttgg gtggcacgta catcacgcct tgttacatta
    13141 tctgccttta acgcatattt ccgctgtagt gcccacattt cttgttgatc aaatccagcg
    13201 ataaatcggc gtccatcaga gcagttggaa cagccagttg caagaggatg aatgtaagga
    13261 ccgataatac cttcaccaaa tgaagtgaat gcacgtagcc atggaatatg attcgatcga
    13321 aacattagct cggcatcatg atgaatagta gaaggagagc catcatgtaa tacgagagcg
    13381 agatgaatat tttcagggag ttcttctgta aggttatgtt ggcgaatgat agaatattgt
    13441 ttgcatagtt gatcatgtac atagtttgca agtaagccat ctcctataag caatatattt
    13501 tgagtcatag actgtcctcc tttgcaatta atacaccgta cacaccatct aagttttctt
    13561 tcaaaaatga ttcaatggct aaatcaaaca cgaatggata aaaattatgt tcttctaaat
    13621 gttgcaaggc aagctgcaca gattgcacac ctggaacttc ttcttccgct tgtatttcca
    13681 ctctaaaaga atccgtgtca tataaaataa tagaggattc aggcaagata ttagctctgt
    13741 aaggagtctc ttcattttga atatgaagta gtgatagttg tagtgcgttt cgtaaggcta
    13801 acgtcatatt aatattagat gcaccgtacc agcgatcatt tataccgacc caaacgacag
    13861 gaaagctgag aatctcttca ctcattgcta ttttaggagg ttcatgaatt gtagagagag
    13921 catcgtaata aaatctacaa tgtttatcat gaattgcagt taaatcaatc gtcgtaattt
    13981 cttctagcat atgtgactgc cgctcataca atttattatt taaatgttgt tgtagcgccc
    14041 ggtatacacc ttctgtcatc gtttctccag cgccaatacc gatatcatta tgttcaggaa
    14101 taaggcggtg cataatttcc gctacatatg tttcaattcc tgctaaacca gcttctcggc
    14161 gcgcttcatt atgagttaaa ccaccacaag tcataagagg caggagggaa gcaggaccat
    14221 ctgatagtgg agtagctact tgaatatggc attgtgataa cggtaattga tatgaatctt
    14281 gttcatccca tacatggaat aaaccagctt ctttagaagt taatgagtcg aaaaagcgga
    14341 ataaatcagt tgaggtatgt tggttggacc gctgctcaag ttgttcagaa agattttcta
    14401 tcgtatcaat tgtaaaactt tcatcagttg cgagaggatg ttttataaaa ggatgccatg
    14461 ctccttcgag tgtttcgtaa tttaataaaa agaattgtgg ttctttttct cggtaagaat
    14521 catcagcgac atgcttaagt aattcaaata cgattatatt tgctaacatt gcagatggaa
    14581 gtggtgaaaa tgatgctgat gaatgttcat tttgtaaagt cgtttcatgt agccgatgcc
    14641 atgcggattc ccagcattct tcacgattag ctgttacgat agggccggct ataccaagtg
    14701 ctgataaaca gacggcaggt atgaagttct ttcctacttc tctacaaatc gtgtgaactg
    14761 ctcttaggcc ttcaatatct ccattttgag aaacatacaa aatccagtcg aaaggctcga
    14821 acacttcatg caggggacga tcaattgtcg tatctatttc ctgaactagg acatgatcat
    14881 caacttcatg tgcaagttct actagctcat gaatgcgatc gtaatttgtt tcctcataat
    14941 ctgtaacaag gtaatgaaag gtaggtaatc ctgattctaa taaagaagaa actaaggaag
    15001 taagcatatc tccagaacca attataagga cgtttgccgc gcgatacgtt tcgaatttta
    15061 gagcgcctga atgagaatca gcttctaaaa attcaatttg tgaagcgtat ctatcaagta
    15121 atgcgctatt taattcatga ggtgcatctt gacttacatc ccgaacgaaa ccattttcat
    15181 ataaaatctc tccaatttca aatacacgat tttgataggg gagagggaga ccatcggtta
    15241 tttctgctaa agaataattc ccgttaaaca ttggcattaa tttttcaatc cagttgtaaa
    15301 ttccatcacc gtccatacga aatgaactgg cattatttcg aaaatagaca cccccgtttg
    15361 agtcggggag gaaaaaagta tccttatttg ctttaagttt tgcatcaatt ggaaggttat
    15421 tcattttaat cctccttacg ttctaggcat acattattag cttatgtaat gaaatttgtc
    15481 ccatatgaat gcaataaaaa aaggctgtag aataattcat tctacagcct gtaatagatt
    15541 attaatctat caaccttcta ataataatga ttttggatct tcaagcatat ctttaacagc
    15601 aacaaggaag ctaactgctt ctttaccatc aacaatacgg tgatcgtaag ataaagcgat
    15661 gtacatcatt ggacggtttt ccatacgttc tgcatcaatt gcaactggac gtacttggat
    15721 tttgtgcatt cctaaaatac ctacttgtgg gctgtttagg attggtgttg acattagaga
    15781 accgaataca ccaccgtttg taattgtgaa tgtaccacct tgtaactctt ttaatgaaag
    15841 tttgttatcg cgtgctttca tacctaaatt acgaatttcg ctttcgattt cagcgaagtt
    15901 taattggtta gcatcgcgta caactggaac aactaatcca tctggagctg ctactgcaat
    15961 accgatatca tagaattttt taatgataag ctcatcgcct tgaatttcag catttaataa
    16021 tgggaattgt tttaatgctg caacaactgc ttttgtgaag aatgacatga agccaagacg
    16081 tacatcatgt tttttctcga aagcatcttt acgctcttta cgtaattcca tgattgcagt
    16141 catatcaact tcgttaaatg ttgttaacat tgcagatgtt tgttgaactt ctacaaggcg
    16201 ttttgcaatt gtttgacggc ggcgggacat tttcacgcgc tcaactggtt tttcgaattc
    16261 cgtttttgca actggagcag gagctggact ttttggagca gctggtgctt cttttggtgc
    16321 ggcagcatga gcttgtacat cgtgtggtct cacacgtcca agtggatctg tgctacgtac
    16381 gtcgtttaag tcgataccta attcacgagc catttttcta gcagctggtg atgcgatagg
    16441 acggttcgta ttcggtaaac cttgtaaagt tgtagtttgc tcagcatttg gtgccgcagc
    16501 tttcggtgct tcagttgttt cttgttttgg ctgttcagca gccggtgcag gtgtacttac
    16561 tgcaactggt gctccgtttg catctaaaat tgcgatagtt gcaccaactt caactgtatc
    16621 cccaggttcg cctagtaact tcgatacaat acctgaatct tctgcaatga tttctacatt
    16681 gactttatca gtttcaagct caacaacgct gccacctttc tcaactttgt cgcctacgtt
    16741 gataagccat tgtgagatag ttccttcagt aatagattct gcaagctcag gtactttaat
    16801 ttcgatcatt ttaaatgtcc tccccttatt tgcctaacgg tgtgtttttt cttcttttgt
    16861 cttcggtaat ctccatttgt tagcttgccc ccgggcagaa tatctgtccg gggagcaagc
    16921 tagaaacctt cattattact ttcagttgct gaaaacttca atttcttgtt tatcttgacg
    16981 gaagttatac ttcacatcta aagcgtgtgc aacaattagt tcttgctcag ctttgtgagc
    17041 gaatggatcg ccaccagatg ggctagagcg atctgggcgt ccaatgtaac ctgttttcac
    17101 tttatctcca gcaagttcaa acagaattgg agccatgtaa tgccatgcgc ccatattacg
    17161 aggttcttct tgaacccaaa taatttcttc taagttttta aagcgtttaa taatagattg
    17221 aactttctca gcagggaatg ggtacagctg ttcaatacga acgacatgaa cttcatctaa
    17281 gttatactca tgtttaccag actcaatttc tgctgctaag tcaatcgcca ttttacctgt
    17341 gcttaaaaca agacgtttta ctttagttgg tttcatgcca aggttttctt gttctagagc
    17401 aggttggaaa cgtccttcgc ttaactgact agcagttgaa agcgtaagtg ggtgacgtaa
    17461 taaactcttt ggcgtcatca atactaatgg tcgaacagcg tctgttccta agatagatgc
    17521 ttgacgacgt aaaatatgga agtattgtgc cgcgctcgtt aagtttgcaa ctgtccagtt
    17581 attctcagcg gctaactgta agaatcgctc tggacgtgca ctagaatgct ctggtccttg
    17641 accttcataa ccgtgcggta atagaagaac taaaccagat ttttgacccc attttgctct
    17701 tcctgctgaa acatattgat caaataatgc ttgcgcagta tttgagaagt caccatattg
    17761 cgcttcccac ataacaagag tttctggagc gaatacgtta taaccatact cgtaaccaac
    17821 aacagcagct tctgataacg gactgttatg aacagagaag gatgcattaa tgtttggtaa
    17881 gcgatgtaat ggtgaatatg tttcatttgt atcagtatcg tgtaatacga tatgacggtg
    17941 cgcgaatgta ccacgctgtg aatcttgacc agttaaacga attggcgtac cttcttgtaa
    18001 aatagaagcg aatgctaatg actcagcaag tgcccattca attttaccgt tctcttcaag
    18061 agcgtcttta cggcgttcaa gaattttctt tactttcgga tatacgttaa agccttctgg
    18121 ccaagatagt agaccttcat taattgcacg aagtgagtca atctcaacac cagtatcaat
    18181 tggctgaatg ccttttgcaa caacatctgg cactttaacg tcaattgttg cagcgctcgt
    18241 atcagctggc ggtacttgtg catagtcaga ttttaattgc tcttgtataa actgagtcat
    18301 tgtttcaacc tcatctgcat ttagaacacc agcagcttgt aattgatctg cataaatagc
    18361 tcttacagtt gggtgatttt taatcttttt gtacacttgt ggttgcgtaa ctgctgggtc
    18421 atccatttcg ttatgaccgt agcggcggta accaattaaa tcgattaaga agtctttttt
    18481 gaacaatata cgatattgaa tcgcaaggtt agcagcagca agacaagctt ctggatcatc
    18541 agcgttcacg tgaacaatcg gaatatcgaa accttttgca aggtcacttg aatatttcgt
    18601 agaacgagaa tcatagctat cagtcgtaaa gccaactgca ttgtttgcga taacatgaat
    18661 tgttccgcct gtttggtacg cgttcaatct gcttaagttc aacgtttcag atacaatacc
    18721 ttgaccaggg aatgcagcat caccatgaac taaaattacg aatgattttg aagtatcttg
    18781 ttctggaaga ccagattttt tacgattctc ttgagccgca cgtgcaaaac cttctacaac
    18841 agggttaacg aactcaaggt gacttgggtt atttgctaat gtaacgcgag tgctaacttc
    18901 ttcgttacta acgacttgtt ctctacctaa atggtatttc acgtcaccag tccagccaga
    18961 atttgccact gcgccttcta tttttgcatg tttgaactca gcaaacatgt gactatatgg
    19021 tttttctaat acgtgtgcaa gtacgcttag acgaccgcgg tgagccatac caatcatgac
    19081 atcttctacg ccgccctttg caccttcgag aacaatttca tctagaacag gtacaagcat
    19141 atcaacgccc tcgatagaga aacgcttttg cccaacgaat gttttatgca agaattgctc
    19201 gaaaccttca acagctgtta aacgttttaa aagagcagtt cgttttttat ttgatagtgg
    19261 ttgacgcaat gaatttgatt ccaccatttg atgcaaccac gcgcgttctt cactatcttg
    19321 tatatgagaa aattcataag ctaaagattt tgtataaacg tcttttaatc tatgaattac
    19381 atcaagtgca gtgtgaatac cttctggtgc atcttgccat actgttttcg ctggaatcgc
    19441 tttcaagtca gcatcgctca gttcgttcat tgctttctca agaagagatt gtccattagc
    19501 agcatcttcc atcggattga tgtgagccaa cgtatgcccg aatgaacgaa tttgttcaac
    19561 aagctgaacg actttaagaa ttttttcaat gttccctgtg ttttgaggag aaaaatgtgt
    19621 tgctgtgttg tcccctgtta cgacatcatc ttgaaacgaa ggagctccaa aaatttcaaa
    19681 aagctcttgt aattccggat caacagaacc tgctccagtt acgtaaagat catattgctc
    19741 aataacataa ccaaggttcg gaccatggaa cttggcccaa gggtttgtcg ttgtattctt
    19801 cctcgtcatt tgtttaaacc tcccaatgca tataatcctt tttccaaaca aaaggtgcat
    19861 tttgctcttt tcaataattg atgaaccaac aatcaatgta aatgttttct ttattcttat
    19921 gttattacaa taatttacat aataccaaac actattactt atctgttttg taaaaaaaca
    19981 ttcacaataa cttatcaccc aagttaatct ttcatgttat aaagtaattt cacagaaaaa
    20041 tggggtggat atatttggta tacctacacg aataactaaa attgttgcat gtaaatataa
    20101 gtataataat tagaatgttt cgataaaaat gagttcgaat tatgtatatt gaaataataa
    20161 gcgctttcat tgatattata caacaatata acggaatata gtataaaaaa taaaaaatta
    20221 tgaatttatc gtaaacttta tttagatagt gttaaatatt gaaaggaaag tgaaggattt
    20281 ctacaaaaaa agttgctaaa cataaaaaat gcttcataaa cagttagttt ctataaatat
    20341 gacgaaaaac accgtaaaac caataacgca tttcgtggaa taaagagatg aatgaaatat
    20401 tttaaaagga taaaacaaat agggagatat taaatttaaa aaatagagag gagaagatat
    20461 agtaacaatt atttacagtg ttccgcgttt catttcaaaa tagacgtgct gaaattgaaa
    20521 agtttcttct atgtaaatag agtgaaacaa actaaaatgc atgtaaagga aacttgacgt
    20581 aaaggatgct ttacatatat actcactgta aggaaggagg gagaaatttc cttggaaaat
    20641 aaaatggttg aataccgaaa aaaatttgga ctatctcaag aaaaattggc tgagaaactt
    20701 ggagtttcca ggcaaaccat catttcaatt gaaaagggaa aatatgatcc atcacttccg
    20761 ttagcatttg aaatagcaaa aacatttcag acaacgatag aacatgtatt tatttatgaa
    20821 ggaaaagaag agggggaata gggatgaatt attcacaaaa gtacttttta attatgggaa
    20881 ttattttctt tattatgagt ggaaccatgg tattagcggg cataatgacg cattccgcac
    20941 caccggctcc aacgtataca gtacttacga tgatgattat gtgtttctgc ttaagttact
    21001 tacacccgca atttaaagaa aaagatgagc gaatgaaact tattcgttat aaaggaatgt
    21061 tcttcagctt ttttgcgcta acggcatatt accttctttt ctctttcggt ttaaatctac
    21121 acgtaattac actatctgcg gttgaactat taaacatact tatggcactt acgatgagta
    21181 cagtttttat ctcatttgtt gttttatcga aaagatatta agatggaaga gagaaaggaa
    21241 gattaacata tgcaaatgat gtatgctttt ggcattggac ttgtattatt tttagccgta
    21301 ttcttattta ttcgaaaaga cgttcaaggt gggacgttaa cgaaaagagg cttttataaa
    21361 atgatcggct gtttagtcgt tatgtttata gcgattatcg taatgatcgt tttaataaat
    21421 caatcactat agaatataaa aatggaacct tactgtagta aggtttttct ttttgatgta
    21481 aaatccgaaa attcccacga catccattta ctacatataa tggatattat ataatttaat
    21541 aaaatgatag acagggagca tagtatatga ataaaaaaac tatcttcttt ttattaacat
    21601 gcctactact tatagctagt attacttata taatatgtaa caaacgagaa caagtgccac
    21661 ctatgttagt atgggagcac caagaatact atgttacgaa tgaacctgcc gaagctgaaa
    21721 aagttggaca aaggctcgga gaagtaacga agaaaattga aacaagtaaa aaacctacta
    21781 aaaacagtga atccaacata gtacaagaaa aaacagaagt attcacaatg atagaggaag
    21841 aaaaaaatcc tcactcatct ttaatcataa aggagcctta tagtgacgaa tatagagtag
    21901 taagaccgat gttacatgta ctataaagtg aaaaggggac tcatatgcag acagtaactt
    21961 atccatggtc gttaagaaaa atgtttgttt ttttcctttg cttcatcctt ccgccaatcg
    22021 gcgcaattta tattttgatg aatcgagaag cgctacaaaa gagagacttc attttatatg
    22081 tattatttgc tgctattaat atatcgcttt ggttatcact tatgatcctc gatcggagcg
    22141 tgtggatggt agcgggtcat tatgtgttcg gagcaattgt tattgttttt tcgaatatga
    22201 ataagagata agccagcaac cttaaagttg ctggttttaa ttttgctatt tataatgagg
    22261 aaataaattt ttaatagaga gtagtgggcg ttatgagatg gaaagagggg acgtttgaaa
    22321 aaatagacac gaatgactca tataaatgct atactaaaaa atgtttgtaa tgtcagtttc
    22381 atactattat ataatgctga cttactagaa aagataagag gagaatgagc gtgcaaaaga
    22441 taaagaaact attactgtta atgatggtag taggattaac agtaggtgtt ttagcagggt
    22501 gtgcaaatcc gaaagatacg acagaagaat ttttaacagc gatacaaaaa ggtgatatag
    22561 aaaaggctcg tacatttgtt gagagtgaca aggaatttaa caaactaaat gaaaaaacag
    22621 atgatgctga ggcaaaagca atgctgagtg caattacgaa aaactttaaa tttgaaaagc
    22681 tagaagaagt atcgaaaaag gatgacaaag cagaagtgaa agtgaaaatt acatctgctg
    22741 atctatccgt tgctgtaaca aaagcagtgg gagaagttat gccaatggcc ttcgctagcg
    22801 cttttagcga agacaaagag caatctgaaa aagcaatcga aaaaacgatg acatcagcaa
    22861 tcgtcaaaca cttatcagat aaagatgcaa tcatggcaac tcgcgaagtt acattgaact
    22921 taaagaaaaa caaagatggc gactataaaa tcgttgcaga tgataacttg aaagaagtat
    22981 tgtttgctaa tgcgaagtct ttggagaaga tgtttcgtgg gaagtgattg atttagataa
    23041 aaaagagaaa ccatatcacg tagaaggttg atacggtttc tcttttttat gaccccggag
    23101 aggctcgaac tcacgacctc caccctgtca aggtggtaaa aagaatgacc ttgaataacc
    23161 taaagggatt agtgggtaat tatagtacgt atttcaataa gtttactaat ccctttgtaa
    23221 tttaaaagtt cctactgttt cctttgttac gtgaccaaga tgtgaccaat gttaacatta
    23281 taatatccac tctgaggttg gtgaaatatt tttggtctta ttctcttttt ttactactcc
    23341 gagcttttta attaattctt catttgccca tagatatttt tcagaagagg tactttttaa
    23401 tgatttaagt tgattttctt gctcctcgtc caaaatcagt tcgtagatat ctgcaattaa
    23461 gatttgataa cagccaaaac gctgttcata tactaatgga ttttgaat
//
