Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
2.1
2.2
3.1
3.2
3.3

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP036070.1 (Bacillus wiedmannii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | azole-containing-RiPP | 1,191,907 | 1,215,414 |
Region 1.2 | NI-siderophore | 1,851,575 | 1,883,280 | High | petrobactin | other:other
Region 1.3 | NRP-metallophore,NRPS | 2,217,627 | 2,269,381 | High | bacillibactin | NRPS:Type I
Region 1.4 | NRPS | 2,354,322 | 2,420,230 | Low | zwittermicin A | NRPS:Type I+PKS
Region 1.5 | betalactone | 2,426,830 | 2,452,067 | Low | fengycin | NRPS:Type I
Region 1.6 | RiPP-like | 2,512,898 | 2,523,230 |
Region 1.7 | RiPP-like | 2,596,666 | 2,606,929 |
Region 1.8 | NRPS | 2,622,230 | 2,669,240 |
Region 1.9 | terpene | 3,402,538 | 3,424,391 | Low | molybdenum cofactor | other:other
Region 1.10 | terpene-precursor | 4,026,161 | 4,047,051 |  |

NZ_CP036071.1 (Bacillus wiedmannii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | RiPP-like | 1 | 10,347 |
Region 2.2 | lanthipeptide-class-ii | 13,306 | 39,669 | High | thusin | ribosomal:RiPP

NZ_CP036072.1 (Bacillus wiedmannii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lassopeptide | 63,674 | 86,405 |
Region 3.2 | NRPS,RRE-containing | 174,616 | 241,899 |
Region 3.3 | thioamide-NRP | 412,164 | 488,194 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | azole-containing-RiPP | 1,191,907 | 1,215,414 |
Region 1.2 | NI-siderophore | 1,851,575 | 1,883,280 | High | petrobactin | other:other
Region 1.3 | NRP-metallophore,NRPS | 2,217,627 | 2,269,381 | High | bacillibactin | NRPS:Type I
Region 1.4 | NRPS | 2,354,322 | 2,420,230 | Low | zwittermicin A | NRPS:Type I+PKS
Region 1.5 | betalactone | 2,426,830 | 2,452,067 | Low | fengycin | NRPS:Type I
Region 1.6 | RiPP-like | 2,512,898 | 2,523,230 |
Region 1.7 | RiPP-like | 2,596,666 | 2,606,929 |
Region 1.8 | NRPS | 2,622,230 | 2,669,240 |
Region 1.9 | terpene | 3,402,538 | 3,424,391 | Low | molybdenum cofactor | other:other
Region 1.10 | terpene-precursor | 4,026,161 | 4,047,051 |  |
Region 2.1 | RiPP-like | 1 | 10,347 |
Region 2.2 | lanthipeptide-class-ii | 13,306 | 39,669 | High | thusin | ribosomal:RiPP
Region 3.1 | lassopeptide | 63,674 | 86,405 |
Region 3.2 | NRPS,RRE-containing | 174,616 | 241,899 |
Region 3.3 | thioamide-NRP | 412,164 | 488,194 |

Compact view
NZ_CP036070.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,191,907 - 1,215,414 nt. (total: 23,508 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EXW41_RS06195: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000569.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001145.5 |  | 0.38 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.38 | ribosomal | kocurin | Kocuria rosea
BGC0000605.5 |  | 0.38 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000569.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001145.5 |  | 0.38 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.38 | ribosomal | kocurin | Kocuria rosea
BGC0000605.5 |  | 0.38 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52
Confidence: strong
Additional weak hits (2):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.31 out of 39.62
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (1191906...1215414)
EXW41_RS06220
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 100
  Score: 180.9
  RRE type: Thiopeptide_F_RRE
  Location: 10 - 89
  Score: 40.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
LexA variant 3 | Repressor of DNA damage response

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP036070.1 - Region 2 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,851,575 - 1,883,280 nt. (total: 31,706 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
EXW41_RS09600: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
EXW41_RS09535: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase
EXW41_RS09505: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

EXW41_RS09565: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.90 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000295.5 |  | 0.53 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002471.3 |  | 0.49 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002464.3 |  | 0.48 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002683.2 |  | 0.47 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.90 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000295.5 |  | 0.53 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001499.5 |  | 0.50 | other (other) | aerobactin | Pantoea ananatis
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002471.3 |  | 0.49 | other (other) | baumannoferrin A, baumannoferrin B | Acinetobacter baumannii AYE
BGC0002464.3 |  | 0.48 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002683.2 |  | 0.47 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.34 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 28.19
Confidence: medium
Additional weak hits (5):
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.97 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.84 out of 32.74
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
FuR variant 1 | Ferric Uptake Regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP036070.1 - Region 3 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,217,627 - 2,269,381 nt. (total: 51,755 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
EXW41_RS11405: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

EXW41_RS11410: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

EXW41_RS11415: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

EXW41_RS11470: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

EXW41_RS11550: Antibiotic biosynthesis monooxygenase

smcogs
  SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: PPTase
EXW41_RS11505: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase protease
EXW41_RS11485: isochorismatase

smcogs
  SMCOG1027: isochorismatase

EXW41_RS11530: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase
EXW41_RS11425: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase
EXW41_RS11475: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthase
EXW41_RS11480: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EXW41_RS11490: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

EXW41_RS11555: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  | 1.05 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  | 0.92 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  | 0.88 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  | 0.86 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  | 0.85 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001833.4 |  |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  |  | 0.75 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002695.2 |  |  | 0.73 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001128.4 |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.80 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.76 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.75 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002695.2 |  | 0.69 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.76 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.71 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.11 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.40 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52
Confidence: medium
Additional weak hits (11):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.90 out of 36.54
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.92 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.47 out of 32.74
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.72 out of 18.46
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.93 out of 32.74
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 18.17 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 3, location 2217626 - 2269381:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EXW41_RS11480: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SVSLYPMSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PMPAQGVVNK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

EXW41_RS11490: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (464..864): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMTFDISALELQALVGGETNLYGPTETTIWSTV
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1524..1937): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQVFGGEINMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP036070.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,354,322 - 2,420,230 nt. (total: 65,909 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase oxidoreductase
EXW41_RS12055: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

EXW41_RS12195: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: PPTase acetyltransferase acyltransferase aminotransferase methyltransferase
EXW41_RS12040: methyltransferase

smcogs
  SMCOG1089: methyltransferase

EXW41_RS12100: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

EXW41_RS12110: acyltransferase 3

smcogs
  SMCOG1088: acyltransferase 3

EXW41_RS12140: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

EXW41_RS12185: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: deacetylase esterase
EXW41_RS12090: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

EXW41_RS12145: thioesterase

smcogs
  SMCOG1004: thioesterase

Isomerases: mutase
EXW41_RS12065: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase
EXW41_RS12125: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EXW41_RS12130: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

EXW41_RS12135: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.72 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.72 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002071.2 |  | 0.70 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.72 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.72 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002071.2 |  | 0.70 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.00 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.64 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.34 out of 24.78
Confidence: medium
Additional weak hits (5):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 27.35 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.00 out of 36.54
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.27 out of 36.53
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.23 out of 25.88
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.00 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2354321 - 2420230:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Thr) + (X - Ala) + (Ser - Leu - D-X - Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EXW41_RS12125: Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (457..866): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

EXW41_RS12130: X - Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (466..870): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWMTFDVSVWEWQFFSGGETNFYGPTEATIYVNA
  Nearest Stachelhaus code(s):
    Glu DVWHFGRINK (71% 8Å match)
    Gln DAWQFGLIDK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1527..1919): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWATFDLSVFEVNTNLAGEYNLYGPSEDTTYSTY
  Nearest Stachelhaus code(s):
    Ala DLFNNALTYK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

EXW41_RS12135: Ser - Leu - X - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (496..901): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFTSGEINLYGPTEATVDVTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1558..1945): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWHAFDSAVQEPFAITGGDINQYGPSENTVVTTD
  Nearest Stachelhaus code(s):
    Pro DVQFIAQVVK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (2600..3000): X
nrpys: Gln, Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASIQQMDILVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (88% 8Å match)
    Ile DAQDLGVVDK (85% 8Å match)
    Gln DAQDLGVVDK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4115..4515): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDVSIQQMDMLVGGEYNVYGPTECTVDATC
  Nearest Stachelhaus code(s):
    Gln or Glu DAQDLGVVDK (85% 8Å match)
    Ile DAQDLGVVDK (82% 8Å match)
    Gln DAQDLGVVDK (76% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CP036070.1 - Region 5 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,426,830 - 2,452,067 nt. (total: 25,238 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EXW41_RS12285: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase transferase
EXW41_RS12290: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

EXW41_RS12310: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

EXW41_RS12350: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Lyases: hydratase
EXW41_RS12305: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
EXW41_RS12300: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

EXW41_RS12315: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.56 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001464.3 |  | 0.42 | other (other) | tetrabromopyrrole | Pseudoalteromonas sp. PS5
BGC0001463.4 |  | 0.42 | other (other) | 2,3,4,5-tetrabromopyrrole | Pseudoalteromonas piscicida
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.56 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001464.3 |  | 0.42 | other (other) | tetrabromopyrrole | Pseudoalteromonas sp. PS5
BGC0001463.4 |  | 0.42 | other (other) | 2,3,4,5-tetrabromopyrrole | Pseudoalteromonas piscicida
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
Additional weak hits (2):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.59 out of 29.25
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
PerR | Peroxide regulator
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP036070.1 - Region 6 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,512,898 - 2,523,230 nt. (total: 10,333 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
EXW41_RS12680: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000883.5 |  | 0.31 | other (other) | arginomycin | Streptomyces arginensis
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001964.2 |  | 0.25 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000883.5 |  | 0.31 | other (other) | arginomycin | Streptomyces arginensis
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001964.2 |  | 0.25 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0000172.5 |  | 0.23 | PKS | Basiliskamide A, Basiliskamide B | Brevibacillus laterosporus PE36
BGC0000381.5 |  | 0.23 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0000433.5 |  | 0.22 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0000455.6 |  | 0.22 | NRPS, saccharide | vancomycin | Amycolatopsis orientalis HCCB10007 (ATCC43491)
BGC0002588.2 |  | 0.22 | other (other) | enduracididine | uncultured bacterium
BGC0001233.5 |  | 0.22 | NRPS | feglymycin | Streptomyces sp. DSM 11171
BGC0001461.5 |  | 0.21 | NRPS | Actinoidin B | Amycolatopsis keratiniphila subsp. nogabecina

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.85 out of 30.25
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.59 out of 32.93
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.56 out of 32.93
Confidence: medium
Additional weak hits (4):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.77 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
LexA variant 3 | Repressor of DNA damage response

NZ_CP036070.1 - Region 7 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,596,666 - 2,606,929 nt. (total: 10,264 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
EXW41_RS13140: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001994.4 |  | 0.35 | other (other) | β-ethynylserine | Streptomyces cattleya NRRL 8057 = DSM 46488

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001994.4 |  | 0.35 | other (other) | β-ethynylserine | Streptomyces cattleya NRRL 8057 = DSM 46488

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.22 out of 18.16
Confidence: strong
Additional weak hits (1):
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.19 out of 32.38
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator

NZ_CP036070.1 - Region 8 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,622,230 - 2,669,240 nt. (total: 47,011 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
EXW41_RS13305: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

EXW41_RS13430: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase
EXW41_RS13425: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase glucanase hydrolase
EXW41_RS13330: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

EXW41_RS13370: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

EXW41_RS13390: Pullulanase, type I

smcogs
  SMCOG1297: Pullulanase, type I

EXW41_RS13400: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs
  SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

EXW41_RS13435: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Lyases: decarboxylase
EXW41_RS13375: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase
EXW41_RS13380: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.63 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.61 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.66 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.63 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.61 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.71 out of 26.33
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.13 out of 29.25
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26
Confidence: medium
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 28.23 out of 31.73
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.81 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19
Confidence: medium
Additional weak hits (4):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.33 out of 36.54
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.26 out of 32.93
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.53 out of 32.38
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.36 out of 33.73
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 2622229 - 2669240:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EXW41_RS13380: X - Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (266..656): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAMAFDISLLELESLLAGELNIYGPTETTICATV
  Nearest Stachelhaus code(s):
    Ala DILICALICK (47% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1303..1683): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVYDGNTLHSGDVSLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
HexR | Glucose-responsive regulator
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CP036070.1 - Region 9 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,402,538 - 3,424,391 nt. (total: 21,854 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EXW41_RS17235: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

EXW41_RS17240: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase
EXW41_RS17210: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.52 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.52 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0002138.2 |  | 0.40 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
EXW41_RS17250: T2TS
Domain 1 (4 - 614): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.42 out of 29.51
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP036070.1 - Region 10 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,026,161 - 4,047,051 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
EXW41_RS20425: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
EXW41_RS20390: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

EXW41_RS20395: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
EXW41_RS20395: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.53 out of 25.88
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19
Confidence: medium
Additional weak hits (1):
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP036071.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,347 nt. (total: 10,347 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002579.2 |  | 0.43 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000624.3 |  | 0.40 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002577.2 |  | 0.39 | ribosomal | lactococcin G | Lactococcus lactis
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001861.4 |  | 0.39 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002579.2 |  | 0.43 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000624.3 |  | 0.40 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002577.2 |  | 0.39 | ribosomal | lactococcin G | Lactococcus lactis
BGC0002698.2 |  | 0.39 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001861.4 |  | 0.39 | ribosomal | bacillicin BAG2O | Bacillus cereus BAG2O-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.31 out of 30.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CP036071.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 13,306 - 39,669 nt. (total: 26,364 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
EXW41_RS26890: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

EXW41_RS26905: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001391.3 |  | 0.84 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001311.5 |  | 0.54 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.52 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0002447.3 |  | 0.52 | ribosomal | cerecyclin | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001391.3 |  | 0.84 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000552.3 |  | 0.54 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001311.5 |  | 0.54 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.52 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0002447.3 |  | 0.52 | ribosomal | cerecyclin | Bacillus cereus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EXW41_RS26890

EXW41_RS29770
Leader:
MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGG
Core:
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
Core with dehydrations:
INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

#### antiSMASH-DB 4.0 matches for EXW41_RS29770

100.0%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
1
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
38
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
1
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
38
71.1%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
2
NTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCR
37
NTWNT +TST I +S GN GKVCTYTVECVNNCR
1
NTWNTISTSTCIAVSHFVGNDGKVCTYTVECVNNCR
36
63.2%
NZ_CP047645.1 and 7 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide
Lanthipeptides: GSN02_RS17445_lanthipeptide
1
INTWNTTATST-SIIISETFGNKGKVCTYTVECVNNC
36
NTWNTT TS +I++SE FGNKGKVCT T EC C
1
FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC
37
with 103 more sequence matches
Only the first 10 are displayed here.
60.5%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
1
INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC
36
NTWNTT TS I++SE GNKGKVCT T EC C
1
FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC
37
52.6%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
5
NTTATSTSIIISETFGNKGKVCTYTVECVNNC
36
NT TSTSI+IS T GN G VCT T EC+ +C
4
NTLTTSTSILISMTLGNNGWVCTATKECMPSC
35
51.3%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
4
WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC
36
W TT TS T +S GN G+VCT TVEC NNC
5
WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC
38
47.4%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
5
NTTATSTSIIISETFGNKGKVCTYTVECVNNC
36
NT TSTSI IS GN G VCT++ EC+ +C
4
NTLTTSTSIFISRGLGNDGWVCTWSKECMPSC
35
47.4%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
3
TWNTTATSTSIIISETF-GNKGKVCTYTVECVNNCR
37
+W T T+ S + + G+KG+VCT TVEC NNCR
2
SWGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR
37
47.4%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
3
TWNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR
37
+W T T+ + + S G+KG+VCT TVEC+NNCR
2
SWGTVLTTLACLGASYALGDKGQVCTATVECINNCR
37
44.7%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
12
SIIISETFGNKGKVCTYTVECVNNC
36
SI +S GN GKVCT+TVEC NNC
8
SITLSVYMGNDGKVCTWTVECQNNC
32
44.7%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
14
IISETFGNKGKVCTYTVECVNNCR
37
ISE GNKG VCT T+EC NNCR
7
FISEALGNKGAVCTGTIECQNNCR
30
42.1%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
4
WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR
37
W T +S S S GN G CT T EC NNC+
4
WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK
38
42.1%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
4
WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR
37
W T +S S S GN G CT T EC NNC+
4
WGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK
38

#### MIBiG 4.0 matches for EXW41_RS29770

34.2%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
15
ISETFGNKGKVCTYTVECVNNC
36
IS GNKG CT TVEC+ +C
6
ISCRLGNKGAYCTLTVECMPSC
27
31.6%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
TSTSIIISETFGNKGKVCTYTVECVNNC
36
T+ + +S GN G CT T EC NC
2
TTNTFSLSNALGNNGGWCTLTKECQPNC
29
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
26
CTYTVECVNNC
36
CT + EC NC
28
CTLSKECQPNC
38
EXW41_RS26895
Leader:
MLKEQKLEKITGLIPESELEEHLSG
EXW41_RS26900
Leader:
MLKEQKLEKITGLIPESELEEHLSG
Shared core:
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
Core with dehydrations:
EDhaDhaGAGDhbPAIVDhbAIDhaAVDhbAVDhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

#### antiSMASH-DB 4.0 matches for EXW41_RS26895

100.0%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
1
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
1
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
70.3%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide
Lanthipeptides: J2M30_RS09845_lanthipeptide
6
GTPAIVTAISAVTAVTAQSPCPTSACSKSC
35
GTPAI +AISA+TAVT QSPCPTSACSKSC
1
GTPAIFSAISAITAVTVQSPCPTSACSKSC
30
48.6%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
6
GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK
37
GTP AI+TA++ T S CPTSAC+ CNK
1
GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK
36
with 78 more sequence matches
Only the first 10 are displayed here.
48.6%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
10
IVTAISAV----TAVTAQSPCPTSACSKSCNK
37
+V+AISA TAV+A TSAC+KSCNK
4
VVSAISATVASATAVSALFTV-TSACTKSCNK
34
48.6%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
6
GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK
37
GTP AI+TA++ T S CPTSAC+ CNK
1
GTPVTAILTALTGTTFTVTLSAASCPTSACTNLCNK
36
45.9%
NZ_CP102975.1 and 1 other:
NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide
Lanthipeptides: NW953_RS00175_lanthipeptide
7
TPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
TPA+V V A TAQ CPT ACS C K
2
TPAVVITGILVAASTAQ--CPTLACSSRCGK
30
43.6%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide
Lanthipeptides: GCN81_RS29290_lanthipeptide
1
ESSGAG-TPAIVTAISAVTAVTA--QSPCPTSACSKSC
35
ES AG TP I+ A + +A Q CPTS C+K C
2
ESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC
39
43.2%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
7
TPAIVTAISAVTAVTAQSPCPTSACSKSC
35
TPA T I A AVTA S CPT+ C+ C
8
TPATPTIIGATIAVTA-SLCPTTKCTSRC
35
43.2%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
6
GTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
T A TA+SA+ VT SAC+KSCNK
6
ATVASATAVSALFTVT-------SACTKSCNK
30
43.2%
NZ_PNGD01000001.1 and 1 other:
NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide
Lanthipeptides: CJ239_RS00165_lanthipeptide
7
TPAIVTAISAVTAVTAQ-----SPCPTSACSKSCNK
37
TP I+ A + VT CPTS C+KSCNK
2
TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSCNK
37
40.5%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide
Lanthipeptides: H9624_RS14885_lanthipeptide
5
AGTPAIVTAISA-VTAVTAQSP--CPTSACSKSC
35
AGT + AI V A++A P CPT AC+ C
1
AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC
34
40.5%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
1
ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC
35
+S AG TP IV A + T + Q CPTS C+K C
2
DSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC
42
40.5%
NZ_BNBJ01000003.1 and 9 others:
NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide
Lanthipeptides: IE304_RS05295_lanthipeptide
1
ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC
35
ES AG TP I+ A + T + Q CPTS C+K C
2
ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC
42

#### MIBiG 4.0 matches for EXW41_RS26895

10.8%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
4
GAGTP
8
G GTP
12
GIGTP
16
9.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
1
ESSGAGTPA
9
ESS PA
31
ESSRPAAPA
39
allorf_19132_19248
Leader:
MKRYLLPFVFFLFSHPLESCHFG
Core:
DSFYFVGCSSFLSNR
Core with dehydrations:
DDhaFYFVGCysDhaDhaFLDhaNR

#### antiSMASH-DB 4.0 matches for allorf_19132_19248

100.0%
NZ_CP036071.1:
Lanthipeptides: allorf_19132_19248_lanthipeptide
1
DSFYFVGCSSFLSNR
15
DSFYFVGCSSFLSNR
1
DSFYFVGCSSFLSNR
15
26.9%
NZ_CP070036.1 and 3 others:
NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16805_lanthipeptide NZ_JADNGF010000061.1 Lanthipeptides: I2E06_RS15650_lanthipeptide NZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16660_lanthipeptide
Lanthipeptides: I6K72_RS03970_lanthipeptide
2
SFYFVGCSSFLS
13
S + VGCS+FL+
11
SSHTVGCSAFLT
22
15.8%
NZ_CYZG01000001.1:
Lanthipeptides: ARA00_RS15445_lanthipeptide
2
SFYFVGCSSFLS
13
S + VGC +FL+
23
SSHTVGCGAFLT
34
allorf_34660_34740
Leader:
MKRHIEKKHKIEFS
Core:
NSTTSVAVYCIK
Core with dehydrations:
NDhaDhbDhbDhaVAVYCysIK

#### antiSMASH-DB 4.0 matches for allorf_34660_34740

100.0%
NZ_CP036071.1:
Lanthipeptides: allorf_34660_34740_lanthipeptide
1
NSTTSVAVYCIK
12
NSTTSVAVYCIK
1
NSTTSVAVYCIK
12

#### Lanthipeptide(s) for EXW41_RS26905

EXW41_RS29770
Leader:
MLDIIKNRKKVKENLELPDTLLEEVEEHSAMGG
Core:
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
Core with dehydrations:
INDhbWNDhbDhbADhbDhaDhbDhaIIIDhaEDhbFGNKGKVCysDhbYDhbVECysVNNCysRG

#### antiSMASH-DB 4.0 matches for EXW41_RS29770

100.0%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
1
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
38
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
1
INTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCRG
38
71.1%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
2
NTWNTTATSTSIIISETFGNKGKVCTYTVECVNNCR
37
NTWNT +TST I +S GN GKVCTYTVECVNNCR
1
NTWNTISTSTCIAVSHFVGNDGKVCTYTVECVNNCR
36
63.2%
NZ_CP047645.1 and 7 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide
Lanthipeptides: GSN02_RS17445_lanthipeptide
1
INTWNTTATST-SIIISETFGNKGKVCTYTVECVNNC
36
NTWNTT TS +I++SE FGNKGKVCT T EC C
1
FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC
37
with 103 more sequence matches
Only the first 10 are displayed here.
60.5%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
1
INTWNTTATSTS-IIISETFGNKGKVCTYTVECVNNC
36
NTWNTT TS I++SE GNKGKVCT T EC C
1
FNTWNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC
37
52.6%
NZ_CP009288.1 and 3 others:
NZ_CP009288.1 Lanthipeptides: PDUR_RS25150_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide NZ_CP076607.1 Lanthipeptides: KP014_RS01580_lanthipeptide
Lanthipeptides: PDUR_RS25150_lanthipeptide
5
NTTATSTSIIISETFGNKGKVCTYTVECVNNC
36
NT TSTSI+IS T GN G VCT T EC+ +C
4
NTLTTSTSILISMTLGNNGWVCTATKECMPSC
35
51.3%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
4
WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC
36
W TT TS T +S GN G+VCT TVEC NNC
5
WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC
38
47.4%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS01820_lanthipeptide
Lanthipeptides: P40081_RS01820_lanthipeptide
5
NTTATSTSIIISETFGNKGKVCTYTVECVNNC
36
NT TSTSI IS GN G VCT++ EC+ +C
4
NTLTTSTSIFISRGLGNDGWVCTWSKECMPSC
35
47.4%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
3
TWNTTATSTSIIISETF-GNKGKVCTYTVECVNNCR
37
+W T T+ S + + G+KG+VCT TVEC NNCR
2
SWGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR
37
47.4%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
3
TWNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR
37
+W T T+ + + S G+KG+VCT TVEC+NNCR
2
SWGTVLTTLACLGASYALGDKGQVCTATVECINNCR
37
44.7%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
12
SIIISETFGNKGKVCTYTVECVNNC
36
SI +S GN GKVCT+TVEC NNC
8
SITLSVYMGNDGKVCTWTVECQNNC
32
44.7%
NZ_CKMQ01000043.1 and 10 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS11585_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS11690_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS11670_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05465_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05980_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00170_lanthipeptide
Lanthipeptides: AE832_RS11585_lanthipeptide
14
IISETFGNKGKVCTYTVECVNNCR
37
ISE GNKG VCT T+EC NNCR
7
FISEALGNKGAVCTGTIECQNNCR
30
42.1%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
4
WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR
37
W T +S S S GN G CT T EC NNC+
4
WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK
38
42.1%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
4
WNTTATSTSII-ISETFGNKGKVCTYTVECVNNCR
37
W T +S S S GN G CT T EC NNC+
4
WGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK
38

#### MIBiG 4.0 matches for EXW41_RS29770

34.2%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
15
ISETFGNKGKVCTYTVECVNNC
36
IS GNKG CT TVEC+ +C
6
ISCRLGNKGAYCTLTVECMPSC
27
31.6%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
9
TSTSIIISETFGNKGKVCTYTVECVNNC
36
T+ + +S GN G CT T EC NC
2
TTNTFSLSNALGNNGGWCTLTKECQPNC
29
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
26
CTYTVECVNNC
36
CT + EC NC
28
CTLSKECQPNC
38
EXW41_RS26895
Leader:
MLKEQKLEKITGLIPESELEEHLSG
EXW41_RS26900
Leader:
MLKEQKLEKITGLIPESELEEHLSG
Shared core:
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
Core with dehydrations:
EDhaDhaGAGDhbPAIVDhbAIDhaAVDhbAVDhbAQDhaPCysPDhbDhaACysDhaKDhaCysNK

#### antiSMASH-DB 4.0 matches for EXW41_RS26895

100.0%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
1
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
1
ESSGAGTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
70.3%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09845_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05870_lanthipeptide
Lanthipeptides: J2M30_RS09845_lanthipeptide
6
GTPAIVTAISAVTAVTAQSPCPTSACSKSC
35
GTPAI +AISA+TAVT QSPCPTSACSKSC
1
GTPAIFSAISAITAVTVQSPCPTSACSKSC
30
48.6%
NZ_CP047645.1 and 5 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17435_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18550_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03735_lanthipeptide
Lanthipeptides: GSN02_RS17435_lanthipeptide
6
GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK
37
GTP AI+TA++ T S CPTSAC+ CNK
1
GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK
36
with 78 more sequence matches
Only the first 10 are displayed here.
48.6%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
10
IVTAISAV----TAVTAQSPCPTSACSKSCNK
37
+V+AISA TAV+A TSAC+KSCNK
4
VVSAISATVASATAVSALFTV-TSACTKSCNK
34
48.6%
NZ_JALAUA010000003.1 and 1 other:
NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04870_lanthipeptide
Lanthipeptides: MOD32_RS04870_lanthipeptide
6
GTP--AIVTAISAVTAVTAQSP--CPTSACSKSCNK
37
GTP AI+TA++ T S CPTSAC+ CNK
1
GTPVTAILTALTGTTFTVTLSAASCPTSACTNLCNK
36
45.9%
NZ_CP102975.1 and 1 other:
NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide
Lanthipeptides: NW953_RS00175_lanthipeptide
7
TPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
TPA+V V A TAQ CPT ACS C K
2
TPAVVITGILVAASTAQ--CPTLACSSRCGK
30
43.6%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide
Lanthipeptides: GCN81_RS29290_lanthipeptide
1
ESSGAG-TPAIVTAISAVTAVTA--QSPCPTSACSKSC
35
ES AG TP I+ A + +A Q CPTS C+K C
2
ESLAAGITPTILPATGVIVGASAALQGGCPTSGCTKRC
39
43.2%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
7
TPAIVTAISAVTAVTAQSPCPTSACSKSC
35
TPA T I A AVTA S CPT+ C+ C
8
TPATPTIIGATIAVTA-SLCPTTKCTSRC
35
43.2%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
6
GTPAIVTAISAVTAVTAQSPCPTSACSKSCNK
37
T A TA+SA+ VT SAC+KSCNK
6
ATVASATAVSALFTVT-------SACTKSCNK
30
43.2%
NZ_PNGD01000001.1 and 1 other:
NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide
Lanthipeptides: CJ239_RS00165_lanthipeptide
7
TPAIVTAISAVTAVTAQ-----SPCPTSACSKSCNK
37
TP I+ A + VT CPTS C+KSCNK
2
TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSCNK
37
40.5%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide
Lanthipeptides: H9624_RS14885_lanthipeptide
5
AGTPAIVTAISA-VTAVTAQSP--CPTSACSKSC
35
AGT + AI V A++A P CPT AC+ C
1
AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC
34
40.5%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
1
ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC
35
+S AG TP IV A + T + Q CPTS C+K C
2
DSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC
42
40.5%
NZ_BNBJ01000003.1 and 9 others:
NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide
Lanthipeptides: IE304_RS05295_lanthipeptide
1
ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC
35
ES AG TP I+ A + T + Q CPTS C+K C
2
ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC
42

#### MIBiG 4.0 matches for EXW41_RS26895

10.8%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
4
GAGTP
8
G GTP
12
GIGTP
16
9.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
1
ESSGAGTPA
9
ESS PA
31
ESSRPAAPA
39
allorf_19132_19248
Leader:
MKRYLLPFVFFLFSHPLESCHFG
Core:
DSFYFVGCSSFLSNR
Core with dehydrations:
DDhaFYFVGCysDhaDhaFLDhaNR

#### antiSMASH-DB 4.0 matches for allorf_19132_19248

100.0%
NZ_CP036071.1:
Lanthipeptides: allorf_19132_19248_lanthipeptide
1
DSFYFVGCSSFLSNR
15
DSFYFVGCSSFLSNR
1
DSFYFVGCSSFLSNR
15
26.9%
NZ_CP070036.1 and 3 others:
NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16805_lanthipeptide NZ_JADNGF010000061.1 Lanthipeptides: I2E06_RS15650_lanthipeptide NZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16660_lanthipeptide
Lanthipeptides: I6K72_RS03970_lanthipeptide
2
SFYFVGCSSFLS
13
S + VGCS+FL+
11
SSHTVGCSAFLT
22
15.8%
NZ_CYZG01000001.1:
Lanthipeptides: ARA00_RS15445_lanthipeptide
2
SFYFVGCSSFLS
13
S + VGC +FL+
23
SSHTVGCGAFLT
34
allorf_34660_34740
Leader:
MKRHIEKKHKIEFS
Core:
NSTTSVAVYCIK
Core with dehydrations:
NDhaDhbDhbDhaVAVYCysIK

#### antiSMASH-DB 4.0 matches for allorf_34660_34740

100.0%
NZ_CP036071.1:
Lanthipeptides: allorf_34660_34740_lanthipeptide
1
NSTTSVAVYCIK
12
NSTTSVAVYCIK
1
NSTTSVAVYCIK
12

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
Additional weak hits (5):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.71 out of 23.43
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.06 out of 32.74
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 25.17 out of 33.73
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EXW41_RS29770 - Class II
  Cleavage pHMM score: -3.40
  RODEO score: 0
  Monoisotopic mass: 3927.0 Da
  Molecular weight: 3929.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3947.4 Da N = 1
    3965.4 Da N = 2
    3983.4 Da N = 3
    4001.5 Da N = 4
    4019.5 Da N = 5
    4037.5 Da N = 6
    4055.5 Da N = 7
    4073.5 Da N = 8
EXW41_RS26895 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 3278.7 Da
  Molecular weight: 3280.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3298.7 Da N = 1
    3316.7 Da N = 2
    3334.7 Da N = 3
    3352.7 Da N = 4
    3370.8 Da N = 5
    3388.8 Da N = 6
    3406.8 Da N = 7
    3424.8 Da N = 8
    3442.8 Da N = 9
EXW41_RS26900 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 3278.7 Da
  Molecular weight: 3280.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3298.7 Da N = 1
    3316.7 Da N = 2
    3334.7 Da N = 3
    3352.7 Da N = 4
    3370.8 Da N = 5
    3388.8 Da N = 6
    3406.8 Da N = 7
    3424.8 Da N = 8
    3442.8 Da N = 9
allorf_19132_19248 - Class II
  Cleavage pHMM score: -5.80
  RODEO score: 0
  Monoisotopic mass: 1655.8 Da
  Molecular weight: 1656.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1674.8 Da N = 1
    1692.8 Da N = 2
    1710.9 Da N = 3
allorf_34660_34740 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 1212.6 Da
  Molecular weight: 1213.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1231.4 Da N = 1
    1249.4 Da N = 2
    1267.4 Da N = 3
EXW41_RS29770 - Class II
  Cleavage pHMM score: -3.40
  RODEO score: 0
  Monoisotopic mass: 3927.0 Da
  Molecular weight: 3929.4 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3947.4 Da N = 1
    3965.4 Da N = 2
    3983.4 Da N = 3
    4001.5 Da N = 4
    4019.5 Da N = 5
    4037.5 Da N = 6
    4055.5 Da N = 7
    4073.5 Da N = 8
EXW41_RS26895 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 3278.7 Da
  Molecular weight: 3280.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3298.7 Da N = 1
    3316.7 Da N = 2
    3334.7 Da N = 3
    3352.7 Da N = 4
    3370.8 Da N = 5
    3388.8 Da N = 6
    3406.8 Da N = 7
    3424.8 Da N = 8
    3442.8 Da N = 9
EXW41_RS26900 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 3278.7 Da
  Molecular weight: 3280.7 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3298.7 Da N = 1
    3316.7 Da N = 2
    3334.7 Da N = 3
    3352.7 Da N = 4
    3370.8 Da N = 5
    3388.8 Da N = 6
    3406.8 Da N = 7
    3424.8 Da N = 8
    3442.8 Da N = 9
allorf_19132_19248 - Class II
  Cleavage pHMM score: -5.80
  RODEO score: 0
  Monoisotopic mass: 1655.8 Da
  Molecular weight: 1656.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1674.8 Da N = 1
    1692.8 Da N = 2
    1710.9 Da N = 3
allorf_34660_34740 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 1212.6 Da
  Molecular weight: 1213.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1231.4 Da N = 1
    1249.4 Da N = 2
    1267.4 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
MexT | Global virulence regulator

NZ_CP036072.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 63,674 - 86,405 nt. (total: 22,732 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
EXW41_RS27540: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.3 |  | 0.52 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0001889.2 |  | 0.49 | ribosomal | fusilassin | Thermobifida fusca YX
BGC0000554.4 |  | 0.45 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.5 |  | 0.44 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002698.2 |  | 0.44 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000626.3 |  | 0.44 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001229.4 |  | 0.43 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.43 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.3 |  | 0.52 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0001889.2 |  | 0.49 | ribosomal | fusilassin | Thermobifida fusca YX
BGC0000554.4 |  | 0.45 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.5 |  | 0.44 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002698.2 |  | 0.44 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000626.3 |  | 0.44 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001229.4 |  | 0.43 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.43 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for allorf_072788_072955

allorf_072788_072955
Leader:
MYKLQLNSIERRGRRNMKKLEAGKVKAYGSFMAVTL
Full core:
AKKNKPGDGTRTKGIRKGL
Putative macrolactam:
AKKNKPGD

#### antiSMASH-DB 4.0 matches for allorf_072788_072955

100.0%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
AKKNKPGDGTRTKGIRKGL
19
AKKNKPGDGTRTKGIRKGL
1
AKKNKPGDGTRTKGIRKGL
19
63.2%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
AKKNKPGDGTRTKGIRK
17
AK KPGDGTR KG+R+
1
AKTKKPGDGTRAKGVRR
17
47.6%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
AKKNKPGDGTRTKGIR
16
AK KPGDG KG R
1
AKSGKPGDGKHGKGKR
16
with 8 more sequence matches
47.4%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
AKKNKPGDGTRTKGIRKG
18
+KK+KPGDG +G+++G
1
SKKSKPGDGKFGRGVKRG
18
42.1%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
AKKNKPGDGTRTKG
14
+KK+KPGDG +G
1
SKKSKPGDGKFGRG
14
25.8%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: allorf_365249_365407_lanthipeptide
Lanthipeptides: allorf_384882_385040_lanthipeptide
3
KNKPGDGTRTKGI
15
KN G+G R KGI
10
KNSKGEGWRMKGI
22
23.1%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: allorf_180567_180686_lanthipeptide
Lanthipeptides: allorf_233241_233360_lanthipeptide
6
PGDGTRTKGIRK
17
PG GTR +R+
10
PGYGTRANAMRR
21
22.2%
NZ_JACHJK010000003.1:
Lanthipeptides: allorf_689014_689217_lanthipeptide
3
KNKPGDGTRTKGIR
16
+ +PG GTRT G+R
14
RRRPG-GTRTPGVR
26
13.6%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13025_lanthipeptide
5
KPGDGTRT
12
KPG+GTR
37
KPGEGTRC
44
13.3%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13030_lanthipeptide
5
KPGDGTR
11
KPG+GTR
38
KPGEGTR
44
10.4%
NZ_JANCLX010000058.1:
Lanthipeptides: allorf_34163_34402_lanthipeptide
5
KPGDGTRTKGIR
16
+PG+G G+R
2
RPGEGAALAGVR
13

#### MIBiG 4.0 matches for allorf_072788_072955

57.9%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
AKKNKPGDGTRTKGIR
16
+KK+KPGDG R KG+R
1
SKKSKPGDGIRGKGVR
16

#### Lassopeptide(s) for allorf_072992_073111

allorf_072992_073111
Leader:
MKKLEAGKVKAYGSFMAVTL
Full core:
AKKNKPGDGTRTKGIRKGL
Putative macrolactam:
AKKNKPGD

#### antiSMASH-DB 4.0 matches for allorf_072992_073111

100.0%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
AKKNKPGDGTRTKGIRKGL
19
AKKNKPGDGTRTKGIRKGL
1
AKKNKPGDGTRTKGIRKGL
19
63.2%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
AKKNKPGDGTRTKGIRK
17
AK KPGDGTR KG+R+
1
AKTKKPGDGTRAKGVRR
17
47.6%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
AKKNKPGDGTRTKGIR
16
AK KPGDG KG R
1
AKSGKPGDGKHGKGKR
16
with 8 more sequence matches
47.4%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
AKKNKPGDGTRTKGIRKG
18
+KK+KPGDG +G+++G
1
SKKSKPGDGKFGRGVKRG
18
42.1%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
AKKNKPGDGTRTKG
14
+KK+KPGDG +G
1
SKKSKPGDGKFGRG
14
25.8%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: allorf_365249_365407_lanthipeptide
Lanthipeptides: allorf_384882_385040_lanthipeptide
3
KNKPGDGTRTKGI
15
KN G+G R KGI
10
KNSKGEGWRMKGI
22
23.1%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: allorf_180567_180686_lanthipeptide
Lanthipeptides: allorf_233241_233360_lanthipeptide
6
PGDGTRTKGIRK
17
PG GTR +R+
10
PGYGTRANAMRR
21
22.2%
NZ_JACHJK010000003.1:
Lanthipeptides: allorf_689014_689217_lanthipeptide
3
KNKPGDGTRTKGIR
16
+ +PG GTRT G+R
14
RRRPG-GTRTPGVR
26
13.6%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13025_lanthipeptide
5
KPGDGTRT
12
KPG+GTR
37
KPGEGTRC
44
13.3%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13030_lanthipeptide
5
KPGDGTR
11
KPG+GTR
38
KPGEGTR
44
10.4%
NZ_JANCLX010000058.1:
Lanthipeptides: allorf_34163_34402_lanthipeptide
5
KPGDGTRTKGIR
16
+PG+G G+R
2
RPGEGAALAGVR
13

#### MIBiG 4.0 matches for allorf_072992_073111

57.9%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
AKKNKPGDGTRTKGIR
16
+KK+KPGDG R KG+R
1
SKKSKPGDGIRGKGVR
16

#### Lassopeptide(s) for allorf_073148_073267

allorf_073148_073267
Leader:
MKKLEAGKVKAYGSFMAVTL
Full core:
AKKNKPGDGTRTKGIRKGL
Putative macrolactam:
AKKNKPGD

#### antiSMASH-DB 4.0 matches for allorf_073148_073267

100.0%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
AKKNKPGDGTRTKGIRKGL
19
AKKNKPGDGTRTKGIRKGL
1
AKKNKPGDGTRTKGIRKGL
19
63.2%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
AKKNKPGDGTRTKGIRK
17
AK KPGDGTR KG+R+
1
AKTKKPGDGTRAKGVRR
17
47.6%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
AKKNKPGDGTRTKGIR
16
AK KPGDG KG R
1
AKSGKPGDGKHGKGKR
16
with 8 more sequence matches
47.4%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
AKKNKPGDGTRTKGIRKG
18
+KK+KPGDG +G+++G
1
SKKSKPGDGKFGRGVKRG
18
42.1%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
AKKNKPGDGTRTKG
14
+KK+KPGDG +G
1
SKKSKPGDGKFGRG
14
25.8%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: allorf_365249_365407_lanthipeptide
Lanthipeptides: allorf_384882_385040_lanthipeptide
3
KNKPGDGTRTKGI
15
KN G+G R KGI
10
KNSKGEGWRMKGI
22
23.1%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: allorf_180567_180686_lanthipeptide
Lanthipeptides: allorf_233241_233360_lanthipeptide
6
PGDGTRTKGIRK
17
PG GTR +R+
10
PGYGTRANAMRR
21
22.2%
NZ_JACHJK010000003.1:
Lanthipeptides: allorf_689014_689217_lanthipeptide
3
KNKPGDGTRTKGIR
16
+ +PG GTRT G+R
14
RRRPG-GTRTPGVR
26
13.6%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13025_lanthipeptide
5
KPGDGTRT
12
KPG+GTR
37
KPGEGTRC
44
13.3%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13030_lanthipeptide
5
KPGDGTR
11
KPG+GTR
38
KPGEGTR
44
10.4%
NZ_JANCLX010000058.1:
Lanthipeptides: allorf_34163_34402_lanthipeptide
5
KPGDGTRTKGIR
16
+PG+G G+R
2
RPGEGAALAGVR
13

#### MIBiG 4.0 matches for allorf_073148_073267

57.9%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
AKKNKPGDGTRTKGIR
16
+KK+KPGDG R KG+R
1
SKKSKPGDGIRGKGVR
16

#### Lassopeptide(s) for allorf_073304_073423

allorf_073304_073423
Leader:
MKKLEAGKVKAYGSFMAVTL
Full core:
AKKNKPGDGTRTKGIRKGL
Putative macrolactam:
AKKNKPGD

#### antiSMASH-DB 4.0 matches for allorf_073304_073423

100.0%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
AKKNKPGDGTRTKGIRKGL
19
AKKNKPGDGTRTKGIRKGL
1
AKKNKPGDGTRTKGIRKGL
19
63.2%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
AKKNKPGDGTRTKGIRK
17
AK KPGDGTR KG+R+
1
AKTKKPGDGTRAKGVRR
17
47.6%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
AKKNKPGDGTRTKGIR
16
AK KPGDG KG R
1
AKSGKPGDGKHGKGKR
16
with 8 more sequence matches
47.4%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
AKKNKPGDGTRTKGIRKG
18
+KK+KPGDG +G+++G
1
SKKSKPGDGKFGRGVKRG
18
42.1%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
AKKNKPGDGTRTKG
14
+KK+KPGDG +G
1
SKKSKPGDGKFGRG
14
25.8%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: allorf_365249_365407_lanthipeptide
Lanthipeptides: allorf_384882_385040_lanthipeptide
3
KNKPGDGTRTKGI
15
KN G+G R KGI
10
KNSKGEGWRMKGI
22
23.1%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: allorf_180567_180686_lanthipeptide
Lanthipeptides: allorf_233241_233360_lanthipeptide
6
PGDGTRTKGIRK
17
PG GTR +R+
10
PGYGTRANAMRR
21
22.2%
NZ_JACHJK010000003.1:
Lanthipeptides: allorf_689014_689217_lanthipeptide
3
KNKPGDGTRTKGIR
16
+ +PG GTRT G+R
14
RRRPG-GTRTPGVR
26
13.6%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13025_lanthipeptide
5
KPGDGTRT
12
KPG+GTR
37
KPGEGTRC
44
13.3%
NZ_CP078093.1:
Lanthipeptides: KVH43_RS13030_lanthipeptide
5
KPGDGTR
11
KPG+GTR
38
KPGEGTR
44
10.4%
NZ_JANCLX010000058.1:
Lanthipeptides: allorf_34163_34402_lanthipeptide
5
KPGDGTRTKGIR
16
+PG+G G+R
2
RPGEGAALAGVR
13

#### MIBiG 4.0 matches for allorf_073304_073423

57.9%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
AKKNKPGDGTRTKGIR
16
+KK+KPGDG R KG+R
1
SKKSKPGDGIRGKGVR
16

#### Lassopeptide(s) for allorf_073459_073575

allorf_073459_073575
Leader:
MKKLEVGKVKGYGSFMAVTL
Full core:
AKTKKPGDGTRAKGVRRR
Putative macrolactam:
AKTKKPGD

#### antiSMASH-DB 4.0 matches for allorf_073459_073575

100.0%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
AKTKKPGDGTRAKGVRRR
18
AKTKKPGDGTRAKGVRRR
1
AKTKKPGDGTRAKGVRRR
18
63.2%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
AKTKKPGDGTRAKGVRR
17
AK KPGDGTR KG+R+
1
AKKNKPGDGTRTKGIRK
17
50.0%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
AKTKKPGDGTRAKGVRR
17
+K KPGDG +GV+R
1
SKKSKPGDGKFGRGVKR
17
with 5 more sequence matches
47.6%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
AKTKKPGDGTRAKGVR
16
AK+ KPGDG KG R
1
AKSGKPGDGKHGKGKR
16
30.8%
NZ_FNBR01000006.1 and 1 other:
NZ_FUYT01000011.1 Lanthipeptides: allorf_180567_180686_lanthipeptide
Lanthipeptides: allorf_233241_233360_lanthipeptide
2
KTKKPGDGTRAKGVRR
17
+ PG GTRA +RR
6
SCRAPGYGTRANAMRR
21
15.9%
NC_017765.1:
Lanthipeptides: allorf_01998108_01998287_lanthipeptide
1
AKTKKPGDGTRAKGV
15
A+ ++P G RA+GV
15
ARCRRPMGGRRARGV
29
14.6%
NZ_JANCLX010000058.1:
Lanthipeptides: allorf_34163_34402_lanthipeptide
5
KPGDGTRAKGVRRR
18
+PG+G GVR R
2
RPGEGAALAGVRIR
15
13.6%
NZ_CP078093.1 and 1 other:
NZ_CP078093.1 Lanthipeptides: KVH43_RS13030_lanthipeptide
Lanthipeptides: KVH43_RS13025_lanthipeptide
5
KPGDGTRA
12
KPG+GTR
37
KPGEGTRC
44

#### MIBiG 4.0 matches for allorf_073459_073575

61.1%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
AKTKKPGDGTRAKGVR
16
+K KPGDG R KGVR
1
SKKSKPGDGIRGKGVR
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.26 out of 26.06
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.34 out of 20.97
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.61 out of 32.93
Confidence: medium
Additional weak hits (1):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.68 out of 32.74
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_072788_072955 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 17
  Monoisotopic mass: 2006.2 Da
  Molecular weight: 2007.3 Da
  Number of bridges: 0
allorf_072992_073111 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 18
  Monoisotopic mass: 2006.2 Da
  Molecular weight: 2007.3 Da
  Number of bridges: 0
allorf_073148_073267 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 19
  Monoisotopic mass: 2006.2 Da
  Molecular weight: 2007.3 Da
  Number of bridges: 0
allorf_073304_073423 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 19
  Monoisotopic mass: 2006.2 Da
  Molecular weight: 2007.3 Da
  Number of bridges: 0
allorf_073459_073575 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 20
  Monoisotopic mass: 1963.2 Da
  Molecular weight: 1964.3 Da
  Number of bridges: 0

RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (63673...86405)
EXW41_RS27530
  RRE type: Stand_Alone_Lasso_RRE
  Location: 5 - 87
  Score: 38.5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
FuR variant 1 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization

NZ_CP036072.1 - Region 2 - NRPS,RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 174,616 - 241,899 nt. (total: 67,284 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EXW41_RS28100: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acetyltransferase aminotransferase
EXW41_RS28075: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

EXW41_RS28080: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Lyases: decarboxylase hydratase
EXW41_RS28065: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

EXW41_RS28095: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase
EXW41_RS28050: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

EXW41_RS28105: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001135.5 |  |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002164.2 |  |  | 0.70 | NRPS | peramine | Epichloe festucae
BGC0001261.3 |  |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001132.4 |  |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  |  | 0.66 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  |  | 0.65 | NRPS | enniatin | Fusarium equiseti
BGC0000307.4 |  |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002286.3 |  |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4 |  |  | 0.63 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002164.2 |  | 0.68 | NRPS | peramine | Epichloe festucae
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.66 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.82 out of 29.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.54 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 28.63 out of 33.73
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.16 out of 29.25
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.83 out of 26.33
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.76 out of 21.55
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
Additional weak hits (7):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.45 out of 31.73
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.38 out of 26.85
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.59 out of 18.46
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.27 out of 25.88
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 19.99 out of 29.72
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.10 out of 26.85
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
RREFinder
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 174615 - 241899:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X - Pro) + (Leu - Tyr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EXW41_RS28050: X - Pro
Search NORINE for peptide: strict or relaxed
AMP-binding (18..408): X
nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSSAFDASVFETLLTSAGSINAYGPTETTVYTVA
  Nearest Stachelhaus code(s):
    Phe DAFTVAAVCK (71% 8Å match)
    Leu or Ile DAFFNGAVYK (44% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1069..1458): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FASSFDVSLYDAFLISAGSINAYGPTEASVATIE
  Nearest Stachelhaus code(s):
    4Me-Pro DVQFIAHVAK (50% 8Å match)
  Stachelhaus code match:
    80% (moderate)

EXW41_RS28105: Leu - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (477..877): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASIMEPLLFVGGELNAYGPTEATVCTTI
  Nearest Stachelhaus code(s):
    Leu DAMLVGAVCK (71% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (1538..1944): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWRYFDSSVSESDLIMGGEVNEYGPTEATVSAMY
  Nearest Stachelhaus code(s):
    Lys DAEDIGTVSK (65% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (180906...202004)
EXW41_RS28035
  RRE type: Pantocin_Microcin_RRE
  Location: 7 - 89
  Score: 28.0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
HipB | Bacterial antitoxin HipB
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_CP036072.1 - Region 3 - thioamide-NRP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 412,164 - 488,194 nt. (total: 76,031 nt) Show pHMM detection rules used
thioamide-NRP: (ATP-grasp and AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
EXW41_RS29110: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

EXW41_RS29115: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

EXW41_RS29205: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

EXW41_RS29235: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

EXW41_RS29245: aldehyde oxidase and xanthine dehydrogenase

smcogs
  SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

EXW41_RS29250: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

EXW41_RS29280: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

EXW41_RS29310: nucleotide sugar dehydrogenase

smcogs
  SMCOG1152: nucleotide sugar dehydrogenase

Transferases: aminotransferase glycosyltransferase transferase
EXW41_RS29165: aminotransferase

smcogs
  SMCOG1019: aminotransferase

EXW41_RS29290: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

EXW41_RS29295: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

EXW41_RS29300: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: deaminase
EXW41_RS29055: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase dehydratase
EXW41_RS29125: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

EXW41_RS29305: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
EXW41_RS29070: argininosuccinate synthase

smcogs
  SMCOG1291: argininosuccinate synthase

EXW41_RS29085: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EXW41_RS29150: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EXW41_RS29170: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

EXW41_RS29175: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

EXW41_RS29230: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

EXW41_RS29315: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EXW41_RS29325: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

EXW41_RS29330: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | thioamide-NRP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.4 |  | 0.58 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.58 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000898.5 |  | 0.52 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000772.5 |  | 0.49 | saccharide | lipopolysaccharide | Brucella melitensis
BGC0002499.2 |  | 0.48 | NRPS, PKS | enteromycin | Streptomyces achromogenes subsp. streptozoticus
BGC0001891.3 |  | 0.48 | other (other) | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000899.4 |  | 0.47 | saccharide | desosamine | Streptomyces narbonensis
BGC0000690.5 |  | 0.47 | saccharide | hydroxystreptomycin | Streptomyces glaucescens
BGC0000245.5 |  | 0.47 | PKS | medermycin | Streptomyces sp. AM-7161
BGC0000760.5 |  | 0.46 | saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.4 |  | 0.58 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.58 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000898.5 |  | 0.52 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000772.5 |  | 0.49 | saccharide | lipopolysaccharide | Brucella melitensis
BGC0002499.2 |  | 0.48 | NRPS, PKS | enteromycin | Streptomyces achromogenes subsp. streptozoticus
BGC0001891.3 |  | 0.48 | other (other) | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0000899.4 |  | 0.47 | saccharide | desosamine | Streptomyces narbonensis
BGC0000690.5 |  | 0.47 | saccharide | hydroxystreptomycin | Streptomyces glaucescens
BGC0000245.5 |  | 0.47 | PKS | medermycin | Streptomyces sp. AM-7161
BGC0000760.5 |  | 0.46 | saccharide | emulsan | Acinetobacter venetianus RAG-1 = CIP 110063

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 26.19 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.49 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.76 out of 21.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.08 out of 21.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.89 out of 33.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.21 out of 28.19
Confidence: medium
Additional weak hits (7):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.75 out of 32.74
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.47 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.48 out of 31.73
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.21 out of 39.62
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EXW41_RS29085: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (13..412): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    ala (Ala)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FWGAFDMSIFSLHLGLAGEVNFYGNTEVNEALSY
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

EXW41_RS29150: X
AMP-binding (5..388): X
nrpys: Phe, Trp

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ANWLFNTSIL-AVAVSSGTSDLYGVAETGLSILN
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

EXW41_RS29315: X
AMP-binding (40..374): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    GSYVYGLIGACTFGISSGGQQVYGSTETAIAATH
  Nearest Stachelhaus code(s):
    Aze DVQFISQIAK (35% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
PerR | Peroxide regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor
ZuR variant 2 | Zinc-responsive repressor