LOCUS       NZ_CP036014            23507 bp    DNA     circular CON 25-JUN-2024
DEFINITION  Bacillus toyonensis strain BPN45/4 chromosome, complete genome.
ACCESSION   NZ_CP036014
VERSION     NZ_CP036014.1
KEYWORDS    RefSeq.
SOURCE      Bacillus toyonensis
  ORGANISM  Bacillus toyonensis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5446351)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5446351)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 191.4x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018739605.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 04:09:16
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,850
            CDSs (total)                      :: 5,697
            Genes (coding)                    :: 5,477
            CDSs (with protein)               :: 5,477
            Genes (RNA)                       :: 153
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 106
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 220
            CDSs (without protein)            :: 220
            Pseudo Genes (ambiguous residues) :: 0 of 220
            Pseudo Genes (frameshifted)       :: 93 of 220
            Pseudo Genes (incomplete)         :: 130 of 220
            Pseudo Genes (internal stop)      :: 65 of 220
            Pseudo Genes (multiple problems)  :: 52 of 220
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:13:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3620442
            Orig. end                         :: 3643949
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036014.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23507
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="5"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23507
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23507
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13507](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13507)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            231..650
                     /locus_tag="EXW33_RS18635"
                     /old_locus_tag="EXW33_19080"
     CDS             231..650
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001084723.1"
                     /locus_tag="EXW33_RS18635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19080"
                     /product="hypothetical protein"
                     /protein_id="WP_001084723.1"
                     /transl_table=11
                     /translation="MNSINIQSILDDLWGATILETHIDLLNDNIKFTLQVIDNGVIKDY
                     KLVLIEVSSFYYVKDDEKRRFAFYDREKVDYLELTTIYYEDPNLSEVKLSLQNEKEWSS
                     KYSTGVNIIIEIWDSILLVEAKQFSLNGKVINLKM"
     gene            1142..2779
                     /locus_tag="EXW33_RS18640"
                     /old_locus_tag="EXW33_19085"
     CDS             1142..2779
                     /GO_function="GO:0004040 - amidase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000472903.1"
                     /locus_tag="EXW33_RS18640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19085"
                     /product="glucosaminidase domain-containing protein"
                     /protein_id="WP_215599882.1"
                     /transl_table=11
                     /translation="MFKKAAAIVLTSSIISIPITGLAETVTTSNTATVNVNAVKQSGWV
                     QQNGKWYYFNPDGTIKKGWLLDNNKWYYLNSSGIMQTGWLFDQGVWYYLNASGAMQTGW
                     LLDQGVWYYLNSNGSMKTGWLLDQGVWYYLNASGAMQTGWLLNQGVWYYLNSNGSMKTG
                     WLLDNNKWYYLNSSGGMKIGWLQDGNNRYYLQNDGSMKIGWLQVNNTWYYLNASGAMQT
                     SWSFIDGSWYYLQNNGAMKTDWLQDGDTWYYLQSNGMMQTGTASINGTTYHFDKSGAWT
                     PENNITATTYLDLDLTYASNVTGAEIDANIKKYHPDSPLIGHGNDFVEAQAKHGVNALY
                     LAAHAILESGYGKSEIAYRKHNLFGLRAYDADPFKYAKYLPTFGDSISYNANYVREKYL
                     EANGSYFNGPTLKGMNVMYSTDQEWSAKIVKIMERIKPFQKKDYVYAKKLSKNPNSLNV
                     DALSSDIPYKTYSQGTTKTVKLATSYYVVPYPFDGTIKSQSVTKNDQGTLATGTPVFIY
                     REDPNGWIEFSLTMNGNKYWVLKAGLNM"
     gene            complement(2982..3815)
                     /locus_tag="EXW33_RS18645"
                     /old_locus_tag="EXW33_19090"
     CDS             complement(2982..3815)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000397498.1"
                     /locus_tag="EXW33_RS18645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19090"
                     /product="hypothetical protein"
                     /protein_id="WP_000397501.1"
                     /transl_table=11
                     /translation="MEFVNSIFQILLTSVIQLFSLIGVIIVIGFLLGYLESLTRMYWSR
                     AFGRKGFLLTAWIGVPIHELGHAIMCVLFRHKIVATQFFPTDTSQGALGYVQHQYNQKS
                     VYQRIGNFFIGIGPIISGITALILFMRYFVPESYFLFNTTLEKTIASTSITLEMVQNML
                     LSTFVLLKSLFTINNLLNPSFWLFLFIAICISAHIALSKPDIKGSIDGVIVMFIVLFLF
                     NIIAELFQYDSNQLIGKVMKYNMYLIAFSSVALLFSCISTLVSFGFYKIRGGRSL"
     gene            4017..4802
                     /locus_tag="EXW33_RS18650"
                     /old_locus_tag="EXW33_19095"
     CDS             4017..4802
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000650096.1"
                     /locus_tag="EXW33_RS18650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19095"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_000650068.1"
                     /transl_table=11
                     /translation="MKCPACHTENAVEAKFCGNCGHSLTEEVVASGVQEENQQSSHAEQ
                     AKETRPNETVEQAKRFTSGYFRFFKQAFQAPTAIMQSGNVEVRNGIVSLVLICFLGACI
                     FYRMMSAGAAVTRTLVPEVYTPTSLGESVTVFFFLLILTLFVGFIIFISGKMMKSSFSF
                     LEVFGIWGTIATPVIAILVLTFLFSFLLIFFSPILLSLATTYIGISIIVAILKLDNGGL
                     DLVYTLLIANVFIGIATFIVLWSYISTVIQAFTQGLTGF"
     gene            4822..6057
                     /locus_tag="EXW33_RS18655"
                     /old_locus_tag="EXW33_19100"
     CDS             4822..6057
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016128956.1"
                     /locus_tag="EXW33_RS18655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19100"
                     /product="YARHG domain-containing protein"
                     /protein_id="WP_001099927.1"
                     /transl_table=11
                     /translation="MNVCTKCGTQFVDGVQFCQNCGTKREIPVVKKKMGSGTKIGITLL
                     ALLVIAIVGLYLYGSSYYAQVAQVDRMITILQERDGEKLAEIITTDDPSVIVTRESFKP
                     LFSYIKENPSYVNELKQYLKQGEKQGDGIERADFSLTKDGKHYFIFDRYKLKARTYYTT
                     LLSNEKGASLKMNGKEIDKTEDKNFQKQYGPFLPGAQVFQVEYKNDHVKLSREEKVVLM
                     KQSQNNVTIDLTLQAQYITVQTNAPGATLYVNQKPVTALTGEEITWGPVATDGSATIYL
                     ERNGESGRETTKVETVTALSAYNLPFEKKSIEKTVVYNVTPPPTTGYVYNGFIFPDSDI
                     RKLTNADLTYVTKEQLKIARNEIYARHGNIFQTKDMQAYFSKQSWYRENPYFTGKLTDI
                     EAYNVELIKSRE"
     gene            complement(6104..6526)
                     /locus_tag="EXW33_RS18660"
                     /old_locus_tag="EXW33_19105"
     CDS             complement(6104..6526)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000336278.1"
                     /locus_tag="EXW33_RS18660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19105"
                     /product="hypothetical protein"
                     /protein_id="WP_000336278.1"
                     /transl_table=11
                     /translation="MCPGLLAQTPDEPQEPKAATPLDQEFSINATIYSARAWLSDNDTY
                     AQDIWKGTRFASASHAGKSIFPSGTIKVINLSADTITVTTSGDSDHNLKTVVAPYSEVA
                     LSPSSLSAVQASTSGKASKVTFLFHIFFSRDPGPAK"
     gene            6726..8060
                     /locus_tag="EXW33_RS18665"
                     /old_locus_tag="EXW33_19110"
     CDS             6726..8060
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001110220.1"
                     /locus_tag="EXW33_RS18665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19110"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_001110250.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-62, bitscore:
                     209.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYVIIGGDAAGMSAAMQIVRNDETANVVTLEKGEIYSYAQCGLP
                     YVISGAIASTEKLIARNVKTFRDKYGIDAKVRHEVTKVDTEKKIVYAKHTETKDVFEFT
                     YDRLLIATGVRPVMPEWEGRELQGIHLLKTIPDTERILKTLETNKVEDVTIIGGGAIGL
                     EMAETFVELGKKVRMIERNDHIGTIYDADMAEYIHKEADKHHIEIVTNENVKAFRGKER
                     VEEIETDKGTYKADLVLVSVGVKPNTDFLEGTNIRTNYKGAIEVNAYMQTNVQDVYAAG
                     DCATHYHVIKEIHDHIPIGTTANKQGRLAGLNMVDKRRSFKGTLGTGIIKFMDLTLART
                     GLNEKEAKGLNIPYKTVKVDSTNMAGYYPNAKPLYLKLLYRSDTKQLLGGQVIGEEGVD
                     KRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAARRAE"
     gene            8179..8626
                     /locus_tag="EXW33_RS18670"
                     /old_locus_tag="EXW33_19115"
                     /pseudo=""
     CDS             8179..8626
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002135035.1"
                     /locus_tag="EXW33_RS18670"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19115"
                     /product="GNAT family N-acetyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLRNLYALYLHDLSKFTTNITIGVNGFFGI"
     misc_feature    8735..8749
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: weak, score: 18.17"
                     /tool="antismash"
     gene            8877..9287
                     /locus_tag="EXW33_RS18675"
                     /old_locus_tag="EXW33_19120"
     CDS             8877..9287
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000996799.1"
                     /locus_tag="EXW33_RS18675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19120"
                     /product="DUF3908 family protein"
                     /protein_id="WP_000996796.1"
                     /transl_table=11
                     /translation="MAINMKTIEEWIAESNARQEEDFGHVVEEMKEVCVGLDNATLIYT
                     KNVFCFGKKVEVLFFFQDHVVIGQEKDEYVEIEKLKYDAITNSNLKTNDKNTTLELKFA
                     NGQTINLDSLNDNYGTKNWLFARQIKSIFKVI"
     gene            complement(9319..9909)
                     /locus_tag="EXW33_RS18680"
                     /old_locus_tag="EXW33_19125"
     CDS             complement(9319..9909)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (48-149). E-value: 4.6e-08. Score:
                     23.4. Matches aSDomain: nrpspksdomains_EXW33_RS18680_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002158829.1"
                     /locus_tag="EXW33_RS18680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19125"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_000025729.1"
                     /transl_table=11
                     /translation="MSILQQLIQQAKNPRGTIGSSMLCIMNAAHTKLTKWALQKVHIKT
                     EAIILDIGCGGGKTIHTLSKRTTFGKIYGIDYSDQAVENSKKANMKDVKTGKVIIHQAN
                     VSSIPYNTNFFDLITAFQTHYFWPDVEHDIKEVLRVLQPNGSFLLVAETFKIQYHMKKF
                     KTTEELINLFYKTGFKSVKCYEERGCICVIGNK"
     aSDomain        complement(9463..9765)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW33_RS18680_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="4.60E-08"
                     /label="EXW33_RS18680_oMT.1"
                     /locus_tag="EXW33_RS18680"
                     /protein_end="149"
                     /protein_start="48"
                     /score="23.4"
                     /tool="antismash"
                     /translation="ILDIGCGGGKTIHTLSKRTTFGKIYGIDYSDQAVENSKKANMKDV
                     KTGKVIIHQANVSSIPYNTNFFDLITAFQTHYFWPDVEHDIKEVLRVLQPNGSFLL"
     gene            complement(10001..11542)
                     /locus_tag="EXW33_RS18685"
                     /old_locus_tag="EXW33_19130"
     CDS             complement(10001..11542)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016108035.1"
                     /locus_tag="EXW33_RS18685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19130"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_001175563.1"
                     /sec_met_domain="PF00881 (E-value: 8.2e-09, bitscore: 34.1,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLDTFLHHLHFTIDEIMPNHEVDWEDAPLPYKLYRNVPVIPLSS
                     EIPISLPNSSTTPTLDEIGPYLLYSFGITQLCQLNSERNLFRRSIPSGGALYPNELYIY
                     LKLDHYPDGIYHYDAAYHRLILLREGNFDSYLTDALGNRCNIHSCFGAAFVSTMFWKNF
                     FKYNNFSYRLQGLDSGVLIGQLLECAKQFGYTNGIYFQFLDRAINHLLGLTEGEESVYA
                     VIPLSTEPNIDWFHDDYRKNKTVTSHDLLQQIPPLAHEHFVRSKHVEGYPMITKINEAS
                     MIESTEHFQTLAHEEYYQHHAHTVQLPKVERLSYDFLQLCKERYSPNDDFTLTKWDAAE
                     LATLLQETSLSFPYYNDLDGKYINENARVSLYGCFYNVKTIENGAYAYNIKTHSIHPIR
                     YGDLRYPLQSSMTMDNVNLFQVPLCLHVVGKKDYYTRALGYRGYRIHQMEAGILVHKLV
                     FAATAMGMGGHPLLSFDTNSCDQLYGIDGGNETSLIQIPVGAYRARNWLKGSLHN"
     gene            complement(11558..13507)
                     /locus_tag="EXW33_RS18690"
                     /old_locus_tag="EXW33_19135"
     CDS             complement(11558..13507)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000191877.1"
                     /locus_tag="EXW33_RS18690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19135"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_000191879.1"
                     /sec_met_domain="YcaO (E-value: 1.9e-84, bitscore: 282.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR03604 (E-value: 6e-143, bitscore:
                     474.5, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQHILLIGDGLLADYVHDQLRKQYSIIRQHTITDELPENINLAL
                     VLHDGSPSTIHHDAELVFRSNHIPWLRAFTSFGEGVIGPYIHPLATGCTHCADGRRFIA
                     GFDQQEMWELQRKYALKSEHVTRRDVRATQNGILQMCQLIHAETEKILAHGHSSLENEL
                     ILLNLQTLQCTRHSFLPDPLCPICSNLPTDTADAAQISLQPSLKTSAETYRCRSIHELN
                     TFLTRDYLDYRVGMLNGKMQHSLLPFADVIINMPLMFGNEGVAGRTHSFALSEATAILE
                     GLERYCGMSPRGKKTNVHGSFHDLEDHALNPLTLGVHTNEHYNRDSFPFKPFNPDYEQN
                     WVWGYSLSQNKPLLVPESIAYYSLGHRDAFVYETSNGCAIGGSLEEAIFHGILEIVERD
                     AFLLTWYAELPLPRLDLSSANDTELQLMIQRLRTITGYELHVFNATMEHGIPSLWVIAK
                     NTRANGMNVVCAGGSHLDPIRAIKSAIHEIAGMLLIADDELEQKREYYEKCLQDPYLVN
                     KMEDHSMLYGLKETEERLHFLLRDDAPVQSFQEMNALQSFDMDLTSDLHQLLNRLHQSG
                     LEVIVVDQTVPLIEQNGLHCVKVMIPGMLPMTFGHHLTRVTGLDRVYTVPMTLGYRAEP
                     LTNEQLNPHPHPFP"
     gene            complement(13504..15423)
                     /locus_tag="EXW33_RS18695"
                     /old_locus_tag="EXW33_19140"
     CDS             complement(13504..15423)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03693"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Heterocycloanthracin_C_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thiopeptide_F_RRE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016513905.1"
                     /locus_tag="EXW33_RS18695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19140"
                     /product="putative thiazole-containing bacteriocin
                     maturation protein"
                     /protein_id="WP_001061541.1"
                     /sec_met_domain="TIGR03693 (E-value: 0.0, bitscore: 1231.4,
                     seeds: 2, tool: rule-based-clusters)"
                     /sec_met_domain="Heterocycloanthracin_C_RRE (E-value:
                     2.9e-54, bitscore: 179.4, seeds: 5, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Thiopeptide_F_RRE (E-value: 1.4e-10,
                     bitscore: 39.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLPAYAKLKANKDTFFLPDSNGGVYFRNNASSFRMDGDGIYNW
                     IEKLMPMFNGDHSLAEITDGLPLPYQHRVFEIGEILYENGFVRDVSQDAPHELNSALLD
                     RYASQIEFLEADSHSGALKFQTYRAANVLILGSGDMLTSLVSSLLESGLPTFHYLVTDY
                     METNYDRIHELVERAYEVDDNVLVQEIDTTIDRPLHEVFEPFDWILYVSQNGDIEGLRT
                     VHTICKEVGKNFIPAICLSTFGLAGPVVTADREECWESAWHRLHETTLQNENASAPFSP
                     ITGAMLANIIVFELFKHVADDSYREKEPQFFLLNCETLEGTWHPFIKHPLATDESFTID
                     TIENLTEKLAQRSNQHTSTELFRFFDSLTSKEAGIFHVWDEQNSYQLPLSQCNIQVATP
                     LSDGPASLLPLMTCAGLTHNEARREAGLTGIETYVAEIIHRLIPEHNDIGIGAGETMTE
                     GVYRALQQHLNNKLYERQSHMLEEITTIDLAEIHDTHCKFYYDALSTIHEAPKIAMSEE
                     ILSFPVVWVGVNDRWYGASSINMTLALRNALQLSLLHIQNEETPYRATVLPESSIILYD
                     TDSFRIEIQADEEIPDVQSLQLALQHLGEHNFYPFVFDLAIESFLKENLDGVYGVLIAK
                     EDGL"
     aSDomain        complement(15124..15423)
                     /aSDomain="Heterocycloanthracin_C_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing C protein in a
                     heterocycloanthracin LAP cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EXW33_RS18695_Heterocycloanthracin_C_
                     RRE.1"
                     /evalue="1.50E-56"
                     /identifier="RREFam011.1"
                     /label="EXW33_RS18695"
                     /locus_tag="EXW33_RS18695"
                     /protein_end="100"
                     /protein_start="0"
                     /score="179.4"
                     /tool="antismash"
                     /translation="MNNLPAYAKLKANKDTFFLPDSNGGVYFRNNASSFRMDGDGIYNW
                     IEKLMPMFNGDHSLAEITDGLPLPYQHRVFEIGEILYENGFVRDVSQDAPHELNS"
     aSDomain        complement(15157..15390)
                     /aSDomain="Thiopeptide_F_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing F protein in a thiopeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EXW33_RS18695_Thiopeptide_F_RRE.1"
                     /evalue="7.20E-13"
                     /identifier="RREFam004.1"
                     /label="EXW33_RS18695"
                     /locus_tag="EXW33_RS18695"
                     /protein_end="89"
                     /protein_start="11"
                     /score="39.3"
                     /tool="antismash"
                     /translation="ANKDTFFLPDSNGGVYFRNNASSFRMDGDGIYNWIEKLMPMFNGD
                     HSLAEITDGLPLPYQHRVFEIGEILYENGFVRD"
     gene            complement(15549..16808)
                     /gene="odhB"
                     /locus_tag="EXW33_RS18700"
                     /old_locus_tag="EXW33_19145"
     CDS             complement(15549..16808)
                     /EC_number="2.3.1.61"
                     /GO_component="GO:0045252 - oxoglutarate dehydrogenase
                     complex [Evidence IEA]"
                     /GO_function="GO:0004149 - dihydrolipoyllysine-residue
                     succinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="odhB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016716916.1"
                     /locus_tag="EXW33_RS18700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19145"
                     /product="2-oxoglutarate dehydrogenase complex
                     dihydrolipoyllysine-residue succinyltransferase"
                     /protein_id="WP_000569924.1"
                     /transl_table=11
                     /translation="MIEIKVPELAESITEGTISQWLINVGDKVEKGGSVVELETDKVNV
                     EIIAEDSGIVSKLLGEPGDTVEVGATIAILDANGAPVAVSTPAPVAEQPKQETAEAPKA
                     AAPTAEQATALQGLPNTNRPIASPAARKMARELGIDLNDVRSTDPLGRVRPHDVQAHAA
                     APKEAPAAPKSPAPAPVAKTEFEKPVERVKMSRRRQTIAKRLVEVQQTSAMLTTFNEVD
                     MSAIMELRKERKDAFEKKHDVRLGFMSFFTKAVVAALKQFPLLNAEIQGDELIIKKFYD
                     IGIAVAAPDGLVVPVVRDANQLNFAEIESEIRNLGMKARDNKLSLKELQGGTFTITNGG
                     VFGSLMSTPILNSPQVGILGMHKIQVRPVAIDAERMENRPMMYLALSYDHRIVDGKEAV
                     SFLVAVKDMLEDPKSLLLEG"
     gene            complement(16939..19806)
                     /gene="odhA"
                     /locus_tag="EXW33_RS18705"
                     /old_locus_tag="EXW33_19150"
     CDS             complement(16939..19806)
                     /EC_number="1.2.4.2"
                     /codon_start=1
                     /gene="odhA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000197121.1"
                     /locus_tag="EXW33_RS18705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19150"
                     /product="2-oxoglutarate dehydrogenase E1 component"
                     /protein_id="WP_000197130.1"
                     /transl_table=11
                     /translation="MTRKNTTTNPWAKFHGPNLGYVIEQYDLYVTGAGSVDPELQELFE
                     IFGAPSFQDDVVTGDNTATHFSPQNTGNIEKILKVVQLVEQIRSFGHTLAHINPMEDAA
                     NGQSLLEKAMNELSDADLKAIPAKTVWQDAPEGIHTALDVIHRLKDVYTKSLAYEFSHI
                     QDSEERAWLHQMVESNSLRQPLSNKKRTALLKRLTAVEGFEQFLHKTFVGQKRFSIEGV
                     DMLVPILDEIVLEGAKGGVEDVMIGMAHRGRLSVLAHVLEKPYTHMFAEFKHAKIEGAV
                     ANAGWTGDVKYHLGREQVVGNEEVSTRVTLANNPSHLEFVNPVVEGFARAAQENRKKSG
                     LPEQDTSKSFVVLVHGDAAFPGQGIVSETLNLSRLNAYQTGGTIHVIANNAVGFTTDSY
                     DSRSTKYSSDLAKGFDIPIVHVNADDPEACLAAANLAIQYRTLFKKDFLIDLIGYRRYG
                     HNEMDDPAVTQPQVYKKIKNHPTVRAIYADQLQAAGVLNADEVETITQFIQEQLKSDYA
                     QVPPADTSDATIHVKVPDVVAKGIQPIDTGVELDSLRAMNEGLLSWPEGFNVYPKVKKI
                     LERRKDALEENGKIEWALAESLAFASILQEGTPIRLTGQDSQRGTFAHRHIVLHDTDTN
                     ETYSPLHRLPNINASFSVHNSPLSEAAVVGYEYGYNVFAPETLVMWEAQYGDFSNTAQA
                     LFDQYVSAGRAKWGQKSGLVLLLPHGYEGQGPEHSSARPERFLQLAAENNWTVANLTSA
                     AQYFHILRRQASILGTEAVRPLVLMTPKSLLRHPLTLSTASQLSEGRFQPALEQENLGM
                     KPNKVKRLVLSTGKMAIDLAAEIESGKHEYNLDEVHVVRIEQLYPFPAEKVQSIMKRFK
                     NLEEIIWVQEEPRNMGAWHYMAPILFELAGDTVKTGYIGRPDRSSPSGGDPFAHKAEQE
                     LIVAHALDVKYNFRQDKQEIEVYSN"
     gene            20774..20989
                     /locus_tag="EXW33_RS18710"
                     /old_locus_tag="EXW33_19155"
     CDS             20774..20989
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000428504.1"
                     /locus_tag="EXW33_RS18710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19155"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_000428507.1"
                     /transl_table=11
                     /translation="MENKMVEYRKKFGLSQEKLAEKLGVSRQTIISIEKGKYDPSLPLA
                     FEIAKTFQTTIEHVFIYEGKEEGEKG"
     gene            20986..21363
                     /locus_tag="EXW33_RS18715"
                     /old_locus_tag="EXW33_19160"
     CDS             20986..21363
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016101524.1"
                     /locus_tag="EXW33_RS18715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19160"
                     /product="hypothetical protein"
                     /protein_id="WP_001000064.1"
                     /transl_table=11
                     /translation="MNDSQKYFVIMGIIFLIMSGFMILAGIMTHSAPPSPTYTLLAMMI
                     MCFCLSYLHPQFKEKDERMKLIRYKGMFFSFFALTAYYLLFSIGLNLKVMTLSAVELLH
                     ILMALTMSTVFISFVVLAKRY"
     gene            21392..21574
                     /locus_tag="EXW33_RS18720"
                     /old_locus_tag="EXW33_19165"
     CDS             21392..21574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002086895.1"
                     /locus_tag="EXW33_RS18720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19165"
                     /product="DUF3976 domain-containing protein"
                     /protein_id="WP_001178305.1"
                     /transl_table=11
                     /translation="MQMMYAFGMGIVLFLAVFLFIRKDVQGGTLTKRGFYKMIGCLVVM
                     FIAIIVMIVLITQSL"
     gene            21710..22072
                     /locus_tag="EXW33_RS18725"
                     /old_locus_tag="EXW33_19170"
     CDS             21710..22072
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001034134.1"
                     /locus_tag="EXW33_RS18725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19170"
                     /product="hypothetical protein"
                     /protein_id="WP_001034135.1"
                     /transl_table=11
                     /translation="MNKKAIFFLLTSLLLVASITYIICNTREQVPPILVWEDQEYYVTD
                     EPAQAEEVGQRLGEVTKKIEASKAPTKNSESNTLQEKTEVFTMIEEKKDDQSPLIIKEP
                     YGDEYRIVRPMLKQVL"
     gene            22090..22359
                     /locus_tag="EXW33_RS18730"
                     /old_locus_tag="EXW33_19175"
     CDS             22090..22359
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001195087.1"
                     /locus_tag="EXW33_RS18730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19175"
                     /product="hypothetical protein"
                     /protein_id="WP_001193096.1"
                     /transl_table=11
                     /translation="MQTIASYPWSLRKIFVFFLCFILPPIGFIYILMNREALQKRDFIL
                     YVLFAAINISLWLSLMIFDRSMWMVAGHDVLSVIVIIVSNMNKG"
     gene            22440..22985
                     /locus_tag="EXW33_RS18735"
                     /old_locus_tag="EXW33_19180"
     CDS             22440..22985
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002168863.1"
                     /locus_tag="EXW33_RS18735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW33_19180"
                     /product="hypothetical protein"
                     /protein_id="WP_001267648.1"
                     /transl_table=11
                     /translation="MRWRAGTFEKIETNHASIEQIINTYKKQNLNGGAVISCFKVHNEN
                     FFKEIPHGEDGHEHFFRRICNSLDIINNLEELKIHTSDKYKFRFKEHQAVMLDGSIAAQ
                     ILWGGAYEAFQERPVAAKQLAINVCQYMFQDRYEDIKVFESDHPWTDWFYDVVWDATWM
                     VLDSKEHKMWLICATDTD"
     misc_feature    complement(22999..23015)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 23.71"
                     /tool="antismash"
ORIGIN
        1 gtgaagagga tgcctctgta acgcagaatg ggtatacgta tggtgataat aatccagtga
       61 tgctgacaaa tccagatgga caggcacctt ggcttattcc tgtagcgata agtggctata
      121 gtgcttataa aggatacaaa ggcaaatcac gtgttaattg attaagaaag tcttataagc
      181 aaatacgtca tacattaaat aaaaaacgtt agaaaaggat gaaaagctac atgaatagta
      241 ttaatataca gtctatatta gatgatttat ggggcgctac cattttagag acacatatag
      301 atttgttaaa tgataatatt aaatttacat tgcaggtaat tgataacgga gtgataaaag
      361 attataaatt agtattgata gaagtgtcat cgttttatta tgttaaagat gatgaaaagc
      421 gtagatttgc attttatgat agagaaaaag tagattattt agaattaaca acgatttatt
      481 atgaagatcc aaatctgagt gaagttaaat tgagtttaca aaatgagaaa gaatggagta
      541 gcaaatattc cacaggagta aatattataa tagagatttg ggattctatt ttgttagttg
      601 aagcaaaaca attttctctt aatggtaaag tgattaatct taaaatgtag ttgtttttta
      661 gtatagttat ttcgttcgga gctgggtatc gtttaggggc aaaaaattac aagcttgcca
      721 acacacctcc gtccaataaa aagcacttaa aacagggaat gcaaaaagct ggaacaaaac
      781 tagaattaaa aacaatgtga tttaacattt tctttgagca attagagtgt agtatataaa
      841 tttataatgg agagtaagca tcaaatttat taataataag agggttttgc agcaccctct
      901 tattaaaaaa gaagaagatg tacaataaaa actaacgagc tgactttaca aatcaacttt
      961 ttccaatcct tctatgaaca tgttccttta taaattcccc ctaaaaactc aatattaata
     1021 attcgaatat tatactatta aatatctaca atgttatagt tgtttttttc gtcttccttg
     1081 ttacaatagt agttagataa ctattaaact aaaaaattaa taaaaggagt actaggaaga
     1141 aatgtttaaa aaagctgcag caattgtctt aacatctagt ataatttcta ttcctataac
     1201 aggtttagct gaaactgtaa caacttctaa tacagcaact gtaaatgtaa atgctgtaaa
     1261 acaatctgga tgggttcaac aaaatgggaa atggtattac ttcaatccag atggcactat
     1321 aaaaaaagga tggcttcttg ataataataa atggtattac ttaaactcaa gcggcattat
     1381 gcaaactggc tggctgtttg atcaaggggt ttggtattat ttaaacgcta gtggagcaat
     1441 gcaaactggc tggctattag atcaaggagt ttggtattat ttaaattcta atggttctat
     1501 gaaaacgggt tggttattag atcaaggagt ttggtattat ttaaacgcta gcggagcaat
     1561 gcaaacgggt tggctattaa atcaaggagt ttggtattat ttaaattcta atggttctat
     1621 gaaaactggc tggcttcttg ataataataa gtggtattac ttaaattcaa gtggcggaat
     1681 gaaaattggt tggctacaag atggaaacaa ccgttattac ctccaaaatg atggatcaat
     1741 gaaaatcgga tggctgcaag tgaataatac gtggtattat ttaaacgcta gtggagcaat
     1801 gcaaacgagt tggtcattta tagatggaag ttggtactat ttacaaaata atggtgcaat
     1861 gaagacggac tggctacaag atggcgatac atggtattat ttgcaatcca acggtatgat
     1921 gcaaactgga actgcttcaa tcaatggaac gacgtaccat ttcgacaaga gcggtgcttg
     1981 gactcctgaa aataacatca ctgctaccac atatttagat cttgatttaa cgtacgcttc
     2041 aaatgtgact ggtgcagaaa ttgatgctaa tattaaaaaa tatcatccag acagcccatt
     2101 aattggacat gggaatgact ttgttgaagc tcaagctaaa catggtgtca atgctcttta
     2161 tttagctgca cacgctattt tagaatcggg atatggtaaa tctgaaattg catatcgtaa
     2221 acataaccta tttgggttac gtgcttacga tgctgatcca tttaagtatg cgaaatattt
     2281 accaactttc ggtgatagta tttcttataa cgcaaactac gtaagagaaa agtacttaga
     2341 agcaaacgga tcatacttta acggaccaac attaaaaggc atgaatgtca tgtattcaac
     2401 agatcaagag tggtctgcta aaatcgtaaa aataatggaa cgtattaaac ctttccagaa
     2461 aaaagattat gtatatgcga aaaaattatc taaaaatcca aactctttaa atgtcgacgc
     2521 cctatcaagt gatattccat ataaaacata ctcacaagga acgacaaaaa ctgttaaact
     2581 agctacttcc tattacgttg taccatatcc atttgatggt acaattaaaa gtcagtcagt
     2641 tacgaaaaat gatcaaggca cactagcaac gggtacacct gtatttattt atcgtgaaga
     2701 tccaaacgga tggattgaat tctcactcac aatgaatgga aataaatatt gggtattaaa
     2761 agctggatta aatatgtaaa taaaataccc cttttagaaa aagctaaaag gggtatttta
     2821 tatgttttaa attattaata ggtttgatga ggttaaagtt gctgtgcgca aatatatgca
     2881 cttgtataac tatcaaagat ttcaaaaaaa ctaagcaacc tgagtccata taaatataga
     2941 actcaggttg cttagttgcg cttttttaat acgggggcat ttcacaacga acgccctcct
     3001 cttattttat aaaacccaaa actaacaagt gtagaaatac acgagaacag cagcgccaca
     3061 ctagaaaatg caatgagata catattatat ttcattactt tcccgatgag ttggttactg
     3121 tcgtactgaa aaagttctgc tattatatta aataaaaaca atacgataaa catgacgatg
     3181 acaccgtcaa tggatccttt aatgtctggt ttacttaaag cgatatgtgc agaaatacaa
     3241 atagcgataa ataaaaataa ccaaaaggaa ggattcaata aattgtttat tgtaaataag
     3301 cttttcaata atacgaacgt cgacaagagc atgttttgaa ccatttctaa agtaatagaa
     3361 gtagatgcaa tcgtcttttc gagagttgta ttaaataaaa aatatgactc tggtacgaaa
     3421 tagcgcatga aaaggattaa tgcagtaata ccagaaataa tagggccaat tccaatgaag
     3481 aaattcccaa ttcgttgata tacacttttt tgattgtatt gatgttgtac gtaacctaac
     3541 gcaccttggc tcgtatctgt tgggaagaac tgcgttgcta caattttatg acgaaatagt
     3601 acgcacataa tggcatgtcc aagttcatga ataggaacac caatccacgc agtcaaaaga
     3661 aatccttttc ttccgaaagc cctcgaccaa tacattcgtg tgagagattc taaataacct
     3721 aatagaaatc cgattacaat gatgactcca attaaagaaa ataactggat cacgcttgta
     3781 aggagtattt gaaaaattga gtttacaaat tccattgcct ttcatccaat ctgtttaaag
     3841 tttcacttta gttgctctgt ttcataatag cattattttt ctagattact agtctatata
     3901 ttttctttca aaagcaggat ttcataatct gtttcttgta gtcatgtttt atgtccaaag
     3961 tcatatattg aacttgtaac atcctataag atatatgctt aaggagggat gagagcgtga
     4021 aatgtccagc atgtcataca gaaaatgcag tagaagcaaa gttttgcggg aattgtggac
     4081 attcgttaac cgaagaagta gtagcaagtg gtgtccaaga agaaaaccag caatcatcgc
     4141 atgcagagca agcgaaggaa actcgtccaa atgaaacggt agagcaagca aagcgtttta
     4201 cgagtggcta ttttcggttt tttaaacagg catttcaagc accgacagcg attatgcaaa
     4261 gtggcaatgt cgaagtgcga aatggaattg tcagtcttgt tcttatttgt tttttaggag
     4321 catgtatttt ttatagaatg atgagtgctg gtgcagctgt tacgagaacg ctagtgccag
     4381 aagtatatac tcctacatct ttgggagaat ctgtaacggt atttttcttt ttattaattt
     4441 taactttgtt tgttggattc attattttta taagtggtaa gatgatgaaa tcctcttttt
     4501 cgtttcttga agtattcggc atatggggaa cgatagcaac gccggttatt gctattttag
     4561 tccttacttt tctttttagt ttcttattaa tctttttctc accgatatta ttatctttag
     4621 ctacaactta tatagggatt agtataattg tagccatatt aaaattagat aacggcggat
     4681 tagatcttgt ttatacactt cttattgcaa atgttttcat tggaatcgca acatttattg
     4741 tactttggtc ttacattagc actgtaattc aagcctttac acagggatta actggcttct
     4801 aatgcaaagg tggttgaacg gatgaatgta tgtacaaagt gtggaacgca gtttgtagat
     4861 ggtgtgcaat tttgtcaaaa ctgcggtaca aagagagaaa ttccagtggt gaagaagaaa
     4921 atggggagcg gtacaaaaat tggcattaca cttttagcac tacttgttat agcgattgtt
     4981 ggattgtatt tgtatggatc atcgtattat gcgcaggtgg cacaagtaga ccggatgatt
     5041 acgattttac aagagagaga cggagaaaaa ttagctgaga ttattacgac agatgaccca
     5101 tcggttattg taacgagaga gagtttcaag cctctatttt catatataaa agaaaatccg
     5161 tcttacgtga atgaattgaa acaatattta aagcaaggtg aaaagcaagg ggacggaatt
     5221 gaaagagcgg atttttcttt aacgaaagac gggaaacatt actttatatt tgatcggtat
     5281 aaattgaagg caaggacgta ttatacgact ttgctttcaa atgaaaaagg tgcatcttta
     5341 aaaatgaacg gaaaagaaat cgataagaca gaagacaaaa attttcagaa gcaatatgga
     5401 ccgtttcttc caggagctca agtgtttcaa gtggaatata aaaatgacca tgtaaaacta
     5461 tcacgcgagg aaaaagttgt acttatgaaa caaagtcaaa ataatgtaac gatagattta
     5521 acgttgcaag cgcaatatat tacagttcaa acgaacgcgc ctggtgcgac attatatgtg
     5581 aatcaaaagc cagttaccgc attgaccgga gaagaaatta cgtggggtcc cgtagcaact
     5641 gatggaagtg cgacgattta tttagaacgc aatggagaaa gcggaaggga aacaacaaaa
     5701 gtagaaacgg taacagcact ttcggcttat aaccttccat tcgaaaagaa aagcatagaa
     5761 aaaacagtcg tttacaatgt tactccgcca cctacgactg ggtatgtata caatggtttt
     5821 atcttccctg atagtgatat tcgaaaatta acgaatgcag atttaacgta tgtaacgaaa
     5881 gaacagttga aaattgctag aaacgaaata tacgcaagac atggaaatat atttcaaacg
     5941 aaagatatgc aagcgtattt ttcaaaacag tcttggtaca gagaaaatcc gtattttaca
     6001 ggaaagctaa cggatattga agcttataat gttgaattga ttaaatcaag agaatagcgt
     6061 tcgtgaaaaa ggtacagtgt gtattactgt accttttcta tgattattta gctggaccag
     6121 gatctcttga gaaaaagatg tgaaagagaa atgtgacttt acttgctttt cctgatgtac
     6181 tagcctgtac ggcggataaa gaactaggtg ataaagctac ttcagaatag ggtgctacga
     6241 ctgttttgag attatgatct gaatctcctg atgtagtaac cgttattgta tctgcagata
     6301 agttaataac tttaatagta ccacttggaa atatggactt accagcatgt gatgctgaag
     6361 cgaagcgagt gcctttccaa atatcttgtg cgtaggtatc gttgtcagat aaccaagcac
     6421 gagcgctgta tatggttgcg ttaatggaaa attcttggtc aagtggcgtg gcggctttcg
     6481 gttcttgcgg ttcatctgga gtttgagcga gaaggccagg gcacatgtat gtttcaccta
     6541 ctttcaatag ttactgttat agcatattaa ccatgttggt tataagacac gacagttacc
     6601 tattcaggca taggtttgtg cactaaattt gtagatgaaa tattatttct ttacaatggg
     6661 aataggtgtt atttctataa aatatggaaa ttgtaaagag taggtaaaaa agaaggagtg
     6721 gtaaagtgaa ctatgtcatt attggcggag atgcagctgg gatgagtgca gccatgcaaa
     6781 ttgtaagaaa cgatgaaact gcaaacgttg tgacgttaga aaaaggtgaa atctattcat
     6841 acgctcagtg cggattaccg tatgtcatta gtggtgctat tgcttcgacg gaaaaattaa
     6901 ttgcgcgtaa cgtgaagacg tttcgtgata agtacggaat tgatgcgaaa gtgcgacatg
     6961 aagtaacgaa agtagatacg gaaaagaaaa ttgtgtacgc aaagcatacg gagacgaaag
     7021 atgtttttga atttacgtat gaccgtttat taattgcgac gggagtgcgt cctgttatgc
     7081 cagaatggga aggacgagag ttacaaggca ttcatctttt aaaaacaatt ccagatactg
     7141 agcgtatatt aaaaacgcta gaaacgaaca aagttgaaga cgtaacaatt attggcggcg
     7201 gtgcgattgg actggagatg gcagaaacat tcgttgaact cggtaaaaaa gtgaggatga
     7261 ttgagcgaaa tgatcatatc ggtacgattt atgatgcaga tatggcggaa tatatacata
     7321 aagaagcgga taaacatcat attgaaattg taacgaatga aaatgtaaaa gcgtttagag
     7381 gaaaagagcg agtagaggag attgaaacgg ataaaggtac gtataaagca gatcttgttt
     7441 tagtatctgt cggagtaaag ccaaatactg attttcttga aggaaccaat atacgtacaa
     7501 attataaagg ggcaattgaa gtaaatgcat atatgcaaac gaatgtgcaa gacgtatatg
     7561 ctgctggtga ttgcgcgaca cattatcacg ttataaaaga aattcatgat catattccaa
     7621 ttggaacgac tgccaataaa caaggacgac ttgctggact caatatggtt gataaacgaa
     7681 gatcatttaa aggtacgtta ggtacaggca ttattaaatt tatggatttg acacttgcga
     7741 gaacaggctt aaatgaaaaa gaagcgaaag ggctcaatat cccgtataaa acagttaaag
     7801 tagattcaac aaatatggcg ggctattatc caaatgcgaa accactttat ttaaaattgc
     7861 tatatcgctc cgatacgaag caattgttgg gtggacaagt aattggggaa gaaggtgtag
     7921 ataagcgtat tgatgtgatt gcaatggcgc ttttcaataa aatgagcatt cacgatttag
     7981 aagacgtcga cttaagttac gcaccaccat ataacagcgt ttgggatcca attcagcaag
     8041 cagcaaggag agcggagtag cacttttaaa gtgctacttt ttttgtaaag ggaagtaatc
     8101 ttttttattg aataataaag agggcgattt ataaaaatgg ttgtagcact ttaaagagtt
     8161 caagaatcag aaaaagaaat attacgtaat ttgtacgcat tatatcttca tgacctttcc
     8221 aaattcacca ctaatataac gattggagta aatggttttt ttggaatata aagatttaca
     8281 cttgttttgg aaaaatgacg gaatcactcc atattttata aaaattgata atagtattgt
     8341 aggattttta ttattattag aacgtccatt tttgaagaaa gaaaacgatt tttgtatgaa
     8401 tgacattttc atattgaatc aatatagggg aaaaggaatc ggtaaacaag ttattgaaaa
     8461 tttactagaa gagaaacgag gacagtattt cgttatcgaa cttctaaaaa atgtaccggc
     8521 agtttcgttt tggaagaaag tatatagaga gttaaacatt gaatttgatg aacgaaaaca
     8581 aatgattgat gatgaagaat gcctcgttca aacgtttaaa atataatgaa ataagtgttc
     8641 ctcgtatatt actttgaaat ttagctttat cccgctattt gtgggagtcg ggttgctcgt
     8701 aaacgcccga ttggtgaggg ctgataatca gtgggggatg aacagccctc ctactgatta
     8761 aagtttcact ttattttgaa tataaggttc acccttgaaa acaaagtacg tatcgcttat
     8821 attgtcatat agtatttgtt tttttacaaa gcaatgaacg aaccaggggg cgcagtatgg
     8881 caattaacat gaaaacaatc gaggaatgga ttgcggaatc aaacgcaaga caggaagaag
     8941 attttggaca cgttgttgaa gagatgaaag aagtatgtgt cggacttgat aatgcgacat
     9001 taatttatac gaaaaatgta ttttgcttcg gtaagaaagt agaagtattg tttttcttcc
     9061 aagaccatgt cgttatcgga caagaaaaag acgaatatgt tgagattgaa aaattaaagt
     9121 atgatgccat tacaaatagt aatttaaaaa caaatgacaa aaatacaacg ttagaattaa
     9181 agtttgctaa cggacaaact atcaatttag atagtttaaa tgataactat ggtacgaaaa
     9241 attggttatt tgcaagacaa attaagagta tctttaaagt aatctagtaa aaaagcagtc
     9301 tcttaagggt ctgctttttt acttatttcc gattacacag atacaacctc tttcttcata
     9361 acatttcaca cttttaaatc ccgtcttata aaaaaggttt attaattctt ccgtcgtttt
     9421 aaatttcttc atatgatatt gaattttgaa agtttcagcc actaataaaa aggatccgtt
     9481 cggttgtaag acgcgaagca cttcttttat atcgtgttca acatcgggcc aaaaataatg
     9541 agtttgaaag gcggtaatga gatcgaagaa gttcgtattg taaggaatag aggagacgtt
     9601 agcttgatga atgattactt tccctgtttt tacatctttc atatttgctt tttttgagtt
     9661 ttcaacagct tgatcggagt aatcaatccc gtatattttc ccaaatgtag ttctttttga
     9721 aagagtgtgt attgttttgc ctccgccaca gccgatatct aatataattg cctctgtctt
     9781 tatatgcact ttttgcaacg cccactttgt taatttcgta tgtgcagcgt tcataataca
     9841 aagcatggaa gaaccaattg ttccacgagg attttttgct tgctgaatta attgttgtaa
     9901 aatgctcaaa tcagactctc cttttatgta agaatatata cttatttcgc tttttataaa
     9961 ttaagtcctt taaaaaagca cgccggtgga cggcgtgctt ttaattatgc aaagaccctt
    10021 ttaaccaatt ccgcgctcga tacgccccaa caggaatttg aataagtgat gtttcatttc
    10081 caccatcaat cccgtacaat tgatcacaag aatttgtatc aaaacttagt aacggatgac
    10141 cacccatccc catagcggtc gcagcgaaaa cgagtttatg aacgagtata ccagcttcca
    10201 tttggtgaat gcgatatcct ctatagccta atgcacgtgt gtagtaatcc ttctttccaa
    10261 ctacatgtaa gcaaagtggt acttgaaaaa ggtttacgtt atccatcgtc atactagact
    10321 gaagggggta acgaaggtct ccataccgaa ttgggtgtat ggaatgtgtt ttaatgttat
    10381 aagcataagc cccgttttca atagttttta cgttataaaa acatccatac aaggagacgc
    10441 gtgcattttc atttatatac ttgccatcaa ggtcgttgta ataggggaag gagagactcg
    10501 tttcttgtag taaagtagcg agctcagctg catcccattt cgttaaagta aagtcatcgt
    10561 taggggagta ccgctcttta caaagctgta agaaatcata cgataaacgc tctactttcg
    10621 gtagctgtac agtgtgcgca tgatgttgat agtactcttc atgagctagt gtttggaagt
    10681 gttctgtcga ttcaatcata gatgcttcat ttatttttgt tatcatcgga tatccttcca
    10741 catgtttgga acgaacgaaa tgctcatgtg ctaaaggtgg aatttgctgc aataagtcat
    10801 gagaagtaac ggttttattt ttacgataat catcgtggaa ccaatctata ttcggttctg
    10861 tacttaaagg aataacagca tacacacttt cttctccttc ggtcagtccg agtaaatgat
    10921 tgattgcacg gtctagaaat tgaaagtata tgccatttgt gtaaccgaat tgtttcgcac
    10981 attcgagtaa ttgaccgatg agaacgccgc tatctaatcc ttgcagacga tacgaaaagt
    11041 tattgtattt aaaaaagttt ttccaaaaca tagtggatac aaatgcagca ccaaagcaag
    11101 aatgtatgtt acagcgattg ccgagtgcgt ctgtaagata agaatcgaaa tttccttcgc
    11161 gaagtaagat aagtcggtga tacgcagcgt catagtggta aatcccgtct ggataatgat
    11221 ccaattttaa atatatatac aattcattcg gatataaagc accacctgaa gggatagacc
    11281 tccggaataa atttctttcg ctattgagct gacataattg ggttatacca aatgaataca
    11341 aaaggtaagg accaatctca tccaaagtag gtgtagtaga agagttcggc aaagatattg
    11401 ggatttctga agagagaggg atgacaggta catttcgata taacttataa ggaagcggtg
    11461 cgtcttccca gtccacctca tgattcggca taatttcatc aatagtgaaa tggagatgat
    11521 gtaaaaaagt atctagctgc atgaaatccc ccctttacta tggaaatgga tgaggatgtg
    11581 gatttaattg ttcgtttgtt aaaggctcag ccctatatcc aagtgtcatc ggtacagtgt
    11641 acactctatc cagtccggta acacgagtga gatggtgacc gaacgtcatc ggtagcatgc
    11701 ctgggatcat gacttttaca caatgtaatc cgttctgctc tataaggggg acggtttgat
    11761 ctacaacgat tacttcgagc ccagattgat gcaaacgatt taaaagttga tgaagatcag
    11821 atgtcaaatc catatcaaac gattgtaatg cattcatttc ttggaacgat tgcaccggag
    11881 catcgtcacg taaaaggaaa tgaagacgtt cttccgtttc ttttaatccg tacagcatac
    11941 tatggtcttc cattttatta acgagataag gatcttgtaa gcatttttcg tagtactctc
    12001 ttttttgctc gagctcatca tctgctatta gtaacatgcc tgctatttcg tgaattgcac
    12061 tttttatagc tcgaatagga tctaaatgag agccccctgc acaaacaacg ttcattccat
    12121 ttgcacgcgt atttttcgca attacccata aactcgggat gccatgttcc atcgtcgcgt
    12181 taaaaacgtg taattcatac ccggtaatcg tgcgtaaccg ctgaatcatt aattgtaatt
    12241 ccgtatcgtt tgctgagcta agatcaaggc ggggaagagg taattcagca taccaagtga
    12301 gcaagaaggc atcacgctct acaatttcta aaatgccgtg aaaaattgct tcttctaaac
    12361 taccaccaat tgcacaacca ttggatgttt catacacgaa agcatcccga tgaccgaggc
    12421 tataataagc gattgattct ggaactaaaa gtggcttgtt ttgtgataaa gaatagcccc
    12481 atacccagtt ttgttcatag tcaggattaa acggcttaaa cggaaaacta tcacgattat
    12541 aatgttcatt tgtatgtaca ccgagtgtga ggggattcag tgcatgatcc tctaaatcat
    12601 gaaaactacc atgcacattt gtcttttttc ctcgaggtga cataccacaa tatcgttcta
    12661 aaccttctaa aatagcagtt gcttcactca gtgcaaatga atgggttcga cctgcaacac
    12721 cttcattccc aaacattaac ggcatgttta taatgacgtc agcgaatggt aataaagaat
    12781 gctgcatttt tccattcaac ataccaaccc ggtaatctaa atagtctctc gttaaaaatg
    12841 tatttagttc atgaatagaa cgacagcgat acgtttcagc acttgttttt aagctcggtt
    12901 gtaaagaaat ctgtgccgca tccgcagtat cagtaggtaa attactacat ataggacaga
    12961 gaggatctgg aagaaaagaa tgccgcgtac attgcagtgt ttgtaagttt agtaaaatga
    13021 gttcattttc taaagaagaa tgtccgtgag ctaatatttt ctccgtttca gcatgaatga
    13081 gctggcacat ttgcagaatg ccattttggg tggcgcgtac atcacgcctc gttacgtgct
    13141 ctgatttcaa tgcatatttc cgctgtaatt cccacatttc ttgttgatca aatccggcga
    13201 taaagcgtcg tccatcggca caatgggtgc atcccgttgc aagaggatga atataaggtc
    13261 cgataacacc ttcaccaaat gaagtaaacg cacgtagcca cggaatatga ttggaacgaa
    13321 aaacaagctc agcatcatga tgaatagtag aaggagagcc gtcatgtaat acgagagcga
    13381 ggttgatatt ttcagggagt tcgtctgtaa ttgtatgttg gcgaatgatg gaatattgtt
    13441 tgcgtaattg atcatgtaca tagtctgcaa gtaggccatc tcctataagc aatatatgtt
    13501 gagtcataga ccgtcctcct ttgcaattaa taccccgtac acaccatcta aattttcttt
    13561 caaaaatgat tcaatcgcta aatcaaacac gaatggataa aaattatgtt ctcctaaatg
    13621 ctgcaaggca agctgtaaag attgcacatc tggaatttct tcgtccgctt gtatttctat
    13681 tcgaaaagaa tcagtgtcat ataaaataat agatgattca ggcaaaacag tagctctgta
    13741 tggagtttct tcattttgaa tgtgaagaag agatagttgt agtgcgttac gtaacgctaa
    13801 cgtcatatta atactggatg cgccatacca tctatcattt acaccgaccc aaacgactgg
    13861 aaaactaaga atctcttcac tcattgctat tttaggtgct tcatgaattg tagagagagc
    13921 atcgtaataa aacttacaat gtgtatcatg aatttcagct aggtcgatcg ttgtaatttc
    13981 ttctagcata tgtgattgcc gctcatatag tttattgttt aaatgttgtt gtagtgcccg
    14041 gtatacacct tctgtcatcg tttccccagc accaataccg atatcgttat gttcaggaat
    14101 aaggcgatga atgatttcag ctacatatgt ttcaattcct gttaaaccag cttcacggcg
    14161 agcttcatta tgagtcaaac cagcgcaagt catcagaggc aggagggaag cgggaccatc
    14221 ggatagtggt gtagctactt gaatattgca ttgtgataac ggtagttgat atgaattttg
    14281 ttcatcccac acatggaata taccagcttc tttagaagtt aatgagtcga aaaaacggaa
    14341 caattcagtt gaagtatgtt ggttggaccg ctgcgcaagt ttttcggtaa gattttctat
    14401 tgtatcaatt gtaaaacttt catcagttgc gagaggatgt tttataaaag gatgccatgt
    14461 cccttcgagt gtttcacagt ttaataaaaa gaattgtggc tctttttctc gatatgaatc
    14521 atcagcgacg tgtttaaata attcaaaaac aattatattt gctaacattg cgccagtaat
    14581 tggtgaaaaa ggagctgatg cattttcatt ttgcaaagta gtttcatgta gccgatgcca
    14641 agctgattcc cagcattctt cacgatcagc tgttacgaca ggaccagcca aaccgaatgt
    14701 tgataaacaa atggcgggta tgaagttctt tcctacttcc ttgcaaatcg tgtgaactgt
    14761 tcttaagcct tcaatgtctc cattttgaga aacgtataaa atccagtcaa agggttcgaa
    14821 cacttcatgc agggggcggt caattgtagt atctatttct tgaacaagta cattgtcatc
    14881 aacttcatat gcacgttcta ctagttcatg aattcggtcg taatttgttt ccatataatc
    14941 tgtgacaagg taatgaaatg taggtaatcc ggattctagt aaagaagaaa ctaaggaagt
    15001 aagcatatcc ccagaaccaa gtataaggac atttgctgcg cggtacgtct ggaattttaa
    15061 agcacctgaa tgagaatcag cttctagaaa ttcaatttgc gaagcatacc tatcgagtaa
    15121 tgcactgttt aattcatgag gtgcatcttg acttacatca cgaacaaaac cattttcata
    15181 taaaatctct ccaatttcaa atacacgatg ttgatagggg agaggaagac catcggttat
    15241 ttctgctaaa gaatgatcac cattaaacat aggcattaat ttttcaatcc agttataaat
    15301 tccatcaccg tccatgcgga atgaactggc gttatttcga aaatagacac ccccgtttga
    15361 gtcgggaagg aagaaagtat ccttatttgc tttaagcttt gcataagctg gaaggttatt
    15421 cattttaatc ctccttacgt tttaagcata cattattagc ttatgtcatg aaatttgtcc
    15481 cgtatgaacg caataaaaaa aggctgtaga atgatttatt ctacagcctc taatagacta
    15541 ttagtctatc aaccttctaa taataatgat tttggatctt caagcatatc tttaacagca
    15601 acaaggaagc taactgcttc tttaccatca acaatacggt gatcgtaaga tagtgcaagg
    15661 tacatcatcg gacgattttc catacgttct gcatcaattg caacgggtct tacttggatt
    15721 ttgtgcattc ctaaaatacc tacttgtggg ctgtttagga ttggtgttga cattagagaa
    15781 ccgaatacac caccgtttgt aattgtaaat gtaccacctt gtagctcttt taatgaaagt
    15841 ttattatcac gtgctttcat acctaaatta cgaatttcgc tttcgatttc agcgaagttt
    15901 aattggttag catcgcgtac aactggaaca actaatccat ctggagctgc tactgcaata
    15961 ccgatatcat agaatttttt aatgataagc tcgtcgcctt gaatttcagc atttaataat
    16021 gggaattgtt ttaatgctgc aacaactgct tttgtgaaga atgacataaa gccaagacgt
    16081 acatcatgtt ttttctcgaa agcatcttta cgctctttac gtaattccat gattgcactc
    16141 atatcaactt cgttaaatgt tgttaacatt gcagatgttt gttgtacttc tacaagacgt
    16201 tttgcaattg tttgacggcg gcgggacatt tttacgcgct caactggttt ttcaaattcc
    16261 gtttttgcaa ctggagcagg agctggactt tttggagcag ctggtgcttc ttttggtgct
    16321 gcagcatgag cttgtacatc atgtggtctc acacgtccaa gtggatctgt gctacgtacg
    16381 tcgtttaagt cgattcctaa ttcacgagcc atttttctag cagctggtga tgcgatagga
    16441 cggttcgtat ttggtaaacc ttgtagagcc gtagcttgtt cagcagttgg agcagcagct
    16501 ttcggtgctt cagctgtttc ttgttttggt tgctcagcca ctggtgcagg tgtacttact
    16561 gccactggtg cgccatttgc atctaaaatt gcgatagttg cgccaacttc aactgtatcc
    16621 ccaggctcgc ctagtaactt tgatacaata cctgaatctt ctgcaatgat ttctacattg
    16681 actttatcag tttcaagctc aacaacgctg ccacctttct caactttgtc acctacgttg
    16741 ataagccatt gtgaaatagt tccttctgta atagattctg caagctcagg tactttaatt
    16801 tcgatcattt taaatgtcct ccccttattt gcctaacggt gtgttttgtc ttctttaatc
    16861 ttcggtaatc tccatttgtt agctcgactt gggcagaata tctgcccaag tcgagccggg
    16921 aaaaattcat tgttactttt agttgctata aacttcaatt tcttgtttat cttgacggaa
    16981 gttatacttc acatctaaag cgtgcgccac aattagttct tgctcagctt tgtgagcgaa
    17041 cggatcgcca ccagatgggc tagaacgatc tgggcgtcca atgtaacctg ttttcactgt
    17101 atctccagct agttcgaaca gaattggagc catgtaatgc catgcaccca tattacgagg
    17161 ttcttcttga acccaaataa tttcttctaa gtttttaaag cgtttcataa tagattgaac
    17221 tttttcagca gggaatggat acaactgttc aatgcgaacg acatgaactt catctaagtt
    17281 gtattcatgt ttaccagact cgatttccgc tgctaagtca atcgccattt tacctgtact
    17341 taaaacaaga cgtttaactt tatttggttt catgccaagg ttttcttgtt ctaaagcagg
    17401 ttggaaacgt ccttcgctta actgactagc agttgaaagc gtaagtgggt gacgtaataa
    17461 actcttcggc gtcataagta ctaaaggtcg aacagcttct gttcctaaaa tagatgcttg
    17521 acgacgcaag atatggaagt actgtgctgc gctcgttaag tttgcaactg tccagttgtt
    17581 ttcagcagct aactgtaaga aacgctctgg acgtgcacta gaatgctctg gtccttgacc
    17641 ttcataaccg tgtggtaata gaagaactaa accagatttt tgaccccatt ttgctcttcc
    17701 agctgaaacg tattgatcaa ataatgcttg cgcagtattt gagaagtcac catattgcgc
    17761 ttcccacata acaagagttt ctggagcaaa tacgttataa ccatactcgt aaccaacaac
    17821 agcagcttct gataacggac tgttatgaac agagaatgaa gcgttaatgt ttggtaagcg
    17881 atgtaatggt gaatatgttt catttgtatc agtatcgtgt aatacgatgt gacgatgcgc
    17941 gaatgtacca cgctgtgaat cttgaccagt taaacgaatt ggtgtacctt cttgtaaaat
    18001 agaagcgaat gctaatgact cagcaagtgc ccattcaatt ttaccgttct cttcaagagc
    18061 atctttacgg cgttcaagaa ttttcttcac cttcggatat acgttaaagc cttctggcca
    18121 agataataga ccttcattca ttgcacgaag tgagtcaagt tcaacaccag tatcaattgg
    18181 ctgaatgcct tttgcaacaa catctggtac tttaacgtga attgttgcat cgctcgtatc
    18241 agctggtggt acttgtgcat aatcagattt taattgttct tgtataaatt gagtaattgt
    18301 ttcaacctca tctgcattta gaacaccagc agcttgtaat tgatctgcat aaattgctct
    18361 tacagttggg tgatttttaa tttttttgta cacttgtggt tgcgtaactg ctgggtcatc
    18421 catttcgtta tgaccgtagc gacggtaacc aattaaatcg attaagaagt cttttttgaa
    18481 caacgtacga tattgaatcg ccaggttagc agcagcaagg caagcttctg gatcatcagc
    18541 gttcacgtga acaatcggga tatcaaaacc ttttgcaagg tcgcttgaat atttcgtaga
    18601 acgagaatca tagctatcag tcgtaaaacc aactgcattg tttgcgataa catgaattgt
    18661 tccgcccgtt tgatacgcgt tcaatctgct taagtttagt gtctcagata caataccttg
    18721 accagggaat gcagcgtcac catgaactaa aactacgaat gatttagaag tatcttgttc
    18781 tggaagacca gactttttac gattttcttg agccgcacgt gcgaaacctt ccacaacagg
    18841 attaacgaac tcaaggtgac tcgggttatt tgctaatgta acgcgagtgc taacttcttc
    18901 attcccaacg acttgttctc tacctaaatg gtatttcacg tcgccagtcc agccagcatt
    18961 tgccactgcg ccttctattt ttgcatgttt gaattcagca aacatgtgag tatatggttt
    19021 ttctaatacg tgagcaagca cgcttagacg accgcggtga gccataccaa tcatgacatc
    19081 ttcaacgccg cctttagcac cttctagcac aatttcatct agaattggta caagcatatc
    19141 aacgccctcg atagagaaac gcttttgccc aacgaatgtt ttatgcaaga attgctcgaa
    19201 accttcaaca gctgttaaac gttttaaaag agcagttcgt tttttatttg ataatggttg
    19261 acgcaatgaa tttgattcca ccatttgatg caaccacgcg cgttcttcac tatcttgtat
    19321 atgtgagaat tcataagcta aagattttgt ataaacgtct tttaatctat gaattacatc
    19381 aagtgcagtg tgaataccct ctggtgcatc ttgccatact gttttagctg gaatcgcttt
    19441 caagtcagca tcgctcaatt cgttcattgc tttctcaaga agagattgtc cgtttgcagc
    19501 atcttccatc gggttgatgt gagccaacgt atgcccgaaa gaacgaatct gttcaacgag
    19561 ttgaacgact ttaagaattt tttcaatgtt acctgtgttt tgaggagaaa aatgtgttgc
    19621 tgtgttgtcc cctgttacga catcatcttg aaacgaagga gctccaaaaa tttcaaaaag
    19681 ctcttgtaat tccggatcaa cagaacctgc tccagttacg taaagatcat actgttcaat
    19741 aacataacca aggttcggac catggaattt ggcccaaggg tttgtcgttg tattcttcct
    19801 cgtcatttgt ttaaacctcc caatgcatat aatccttttc ctatacaaaa ggtgcatttt
    19861 gctctttttc aataattgat gaactaataa ttaatgtaaa tgttgtcttt actcttatgt
    19921 tattacaata atttacataa taccaaacac tattacttat ctgttttgta aaaaaacatt
    19981 cacaataact tatcacccaa gttaatcttt catgttataa agtaatttta cagaaaaatg
    20041 gagtggatat atttggtata cctacactaa caactataat tgttgcattt acatataggt
    20101 ataatagtta gaatgtttcg ataaaataaa gttcgaatta tgtatattga aataataagc
    20161 gctttcattg atattataca acaatataac ggaatatagt ataaaaaata aaaaattatg
    20221 aatttagagt aaactttatt tcggtagtgt taaatattga aaggaaaacg aaggatttct
    20281 acaaaaaaag tggctaaaca taaaaaatgc ttcataaacc gttagtttct attaatatgc
    20341 cgaaaaatac cgtaaaacaa ataacgcatt tcatctaata aagcggcaaa tgaaatattt
    20401 taaaaggata aaacaaatat ggagatatta aatttttata aaaatggaga agggatatag
    20461 taacggatat atacattgtt ccatgttgca ttacaaaata gacgtgctga aattgaaaaa
    20521 gtttcttcta taataaagtg aaactttaat cagtgtgggg tttgtccatc caccactgat
    20581 tattagcctt caccaatcgg gcagttattt cccacctaaa ttcctcgtat tcactgaatt
    20641 ttgaggtggg agtcttactg cctgttaatg cgggataaat agcgtgaaac aaactgaaat
    20701 atatgtaaag gaaacttgac gtaaagttta ctttacatat atactcgata taagggagga
    20761 gggagaaatt tccttggaaa ataaaatggt cgaatatcga aaaaaatttg gactatctca
    20821 agaaaaattg gctgagaaac ttggagtttc cagacaaacc atcatttcaa ttgaaaaagg
    20881 gaaatatgat ccatcacttc cattagcatt tgaaatagcg aaaacatttc aaacaacgat
    20941 agaacatgta tttatttatg aaggaaaaga agagggggag aaaggatgaa tgattcacaa
    21001 aagtattttg ttattatggg aattatcttt ttaattatga gtggatttat gatactagca
    21061 ggtataatga cacattcagc accaccaagt cctacttata cgttactagc aatgatgatt
    21121 atgtgtttct gcttaagtta cttacacccg caatttaaag aaaaagatga gcgaatgaaa
    21181 ctcattcgtt ataaagggat gttcttcagt ttttttgcat taacagcgta ttatctcctt
    21241 ttctctatcg gcttaaattt aaaagtaatg acactatctg cggttgaact attacatata
    21301 cttatggcac ttacaatgag taccgtcttt atctcatttg ttgttttggc aaaaagatat
    21361 taagatggaa gagagaaagg aagattaaca tatgcaaatg atgtatgctt ttggtatggg
    21421 gatcgtttta tttttagcgg tgttcctatt cattcgtaaa gacgttcaag gcgggacgtt
    21481 aacgaaacga ggattttata aaatgattgg ctgtttagtt gttatgttta tagcgatcat
    21541 cgtaatgatt gtattaatta ctcaatcatt ataaatttta aaaatgaaac cttacttttt
    21601 gtaaggtttt tctttttgta taaaaaccta aaaattacca caaaaaccat ttactacatg
    21661 gaagctatat tgtataatcc aataaaataa tagaaaagga gaatagtata tgaataaaaa
    21721 agctatcttc tttttattaa caagtctact acttgtagct agtattactt atataatatg
    21781 taacacacga gaacaagtac cacctatatt agtatgggag gaccaagaat actacgttac
    21841 ggatgaacct gctcaagcag aagaagtcgg gcaaaggctc ggagaagtga caaagaaaat
    21901 tgaagcaagt aaagcaccta ctaaaaatag tgaatctaat acattacaag aaaaaacaga
    21961 agtattcaca atgattgaag aaaaaaaaga tgatcaatcg cctttaatca taaaggaacc
    22021 ttatggtgat gaatatagaa tagtaaggcc gatgttaaag caagtactat aatagaaaag
    22081 gagactcata tgcagacaat agcttcatat ccgtggtcgt taagaaaaat atttgtcttt
    22141 ttcctttgct ttattctgcc tcctatcggt ttcatttata ttttgatgaa tagagaagca
    22201 ctacaaaaga gagatttcat tttatatgta ttatttgctg ctattaatat atcgctttgg
    22261 ttatcattga tgatttttga taggagtatg tggatggtag cggggcatga tgtgcttagc
    22321 gtaattgtta ttattgtttc gaatatgaat aagggataac ccagcaattt taaagttgct
    22381 gggttttatt ttgatattta taatgaaata acaaatcttt aatagagagt agtggcatta
    22441 tgagatggag agcaggaacg tttgaaaaaa tagaaacaaa ccatgcatct attgaacaaa
    22501 ttataaatac atataagaaa caaaacttaa atggtggagc ggttataagc tgttttaaag
    22561 tacataacga aaactttttc aaagaaatac cacatggaga agatggacac gagcactttt
    22621 tcagaagaat ctgcaactct ttagatataa tcaataactt agaagaatta aaaatacata
    22681 catcagataa atataagttt cgttttaaag agcatcaggc agtcatgctt gatggtagca
    22741 ttgccgctca aattttgtgg ggcggagcgt atgaagcatt tcaagaacgg ccggttgctg
    22801 cgaagcaatt agcgattaat gtatgccaat atatgttcca agatcgatac gaagatatta
    22861 aagtgtttga aagtgaccac ccttggacag attggtttta cgatgttgta tgggatgcta
    22921 cttggatggt attagatagt aaggagcata aaatgtggtt aatttgtgct acggatacgg
    22981 attaaaagat aaagagtctt gtagaaatgc tacaaggctc tttatctttt gggaaagaat
    23041 agaaaataaa tcgtataaat gttatactaa aaaatgtttg taatgtaagt tttatactgt
    23101 tgtatagtga tggcttacta gaaaagaaaa ggtaaggtaa gaggagaatg aacgtgaaaa
    23161 aggtaaagaa attattgcta ctaatgatgg taatagggtt aacagttggt gttctagcag
    23221 gatgtgcaaa cccgaaagat actgctgaag aatttttaac agcaatacaa aaaggggatg
    23281 tagagaaggc tcgtacattc gttgaaagtg acaaggaatt taataaacta aatgaaaaaa
    23341 cagatgatgc tgaagcaaaa gaaatgctaa gcgcaattac gaaaaacttt aaatttgaaa
    23401 aactagaaga agtatcaaaa acagatgata aagcagaagt gaaagtgaaa attacatctg
    23461 ctgatctatc tgttgccgta acgaaagcaa tgggagaagt tatgcca
//
