LOCUS       NZ_CP035994            25238 bp    DNA     circular CON 25-JUN-2024
DEFINITION  Bacillus mycoides strain BPN36/2 chromosome, complete genome.
ACCESSION   NZ_CP035994
VERSION     NZ_CP035994.1
KEYWORDS    RefSeq.
SOURCE      Bacillus mycoides (Bacillus weihenstephanensis)
  ORGANISM  Bacillus mycoides
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
            Bacillus cereus group.
REFERENCE   1  (bases 1 to 5347123)
  AUTHORS   Fiedoruk,K., Drewnowska,J.M. and Swiecicka,I.
  TITLE     The dynamics of pangenome and proteome of selected Bacillus cereus
            sensu lato representatives from the primary and anthropologically
            changes environments
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5347123)
  AUTHORS   Drewnowska,J.M., Fiedoruk,K. and Swiecicka,I.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-FEB-2019) Department of Microbiology, University of
            Bialystok, 1J Ciolkowskiego, Bialystok 15-245, Poland
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. 0.4.3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 168.724x
            Sequencing Technology :: Illumina MiSeq and MiniIon Oxford Nanopore
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018739445.1-RS_2024_06_25
            Annotation Date                   :: 06/25/2024 04:17:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,019
            CDSs (total)                      :: 5,865
            Genes (coding)                    :: 5,631
            CDSs (with protein)               :: 5,631
            Genes (RNA)                       :: 154
            rRNAs                             :: 14, 14, 14 (5S, 16S, 23S)
            complete rRNAs                    :: 14, 14, 14 (5S, 16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 234
            CDSs (without protein)            :: 234
            Pseudo Genes (ambiguous residues) :: 0 of 234
            Pseudo Genes (frameshifted)       :: 100 of 234
            Pseudo Genes (incomplete)         :: 149 of 234
            Pseudo Genes (internal stop)      :: 70 of 234
            Pseudo Genes (multiple problems)  :: 74 of 234
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 11:36:06
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2489624
            Orig. end                         :: 2514862
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP035994.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25238
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="5"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..25238
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25238
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:15238](+)"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15238
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     misc_feature    753..766
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 20.02"
                     /tool="antismash"
     gene            complement(965..1534)
                     /locus_tag="EXW32_RS12480"
                     /old_locus_tag="EXW32_12805"
     CDS             complement(965..1534)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000782792.1"
                     /locus_tag="EXW32_RS12480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12805"
                     /product="methyltransferase"
                     /protein_id="WP_215586044.1"
                     /transl_table=11
                     /translation="MKMKRKIMMTTALAATLATGALPSTSVFAAEIEAPIQQEEIQMSI
                     QPFAQNNLETAVKAALNGPEVKKIKVFEHEFNVKPIEVVNLGGGKTYVKGQISHHLSFR
                     PDDQFYYEFTVQDGKVIDKPVFNIDRGGWTPFTAPLLSILAAYNGIPVNPNDLNALGQQ
                     IGKVIDGSWEHAAQSIATVVSLSFNE"
     misc_feature    1861..1874
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    complement(1982..1997)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 21.04"
                     /tool="antismash"
     misc_feature    2072..2090
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 22.89"
                     /tool="antismash"
     gene            2135..2977
                     /locus_tag="EXW32_RS12485"
                     /old_locus_tag="EXW32_12810"
     CDS             2135..2977
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Metallophos_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002141840.1"
                     /locus_tag="EXW32_RS12485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12810"
                     /product="metallophosphoesterase"
                     /protein_id="WP_002032218.1"
                     /sec_met_domain="Metallophos_2 (E-value: 7e-09, bitscore:
                     34.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKKIKRIILIIGILVGISIFLYLQNNLISITEVKITSSKIPSSF
                     KGYKILQISDLHNKKFGDNQDVLIQKVKSINPDIIAITGDLIDSKSYDAEMSMQVIREL
                     VKEYPVYFVTGNHEKWSGKYNSLEKKLKKQHVTVLRNEHVIIQKGGHEINLLGIDDPEF
                     NTGDIDEGSIVKDAIVKAKIETLPDRYNVLLSHRPEFLEAYADEQVDLVLSGHAHGGQV
                     RLPFIGGLVAPNQGILPKYTAGLYEQQNTSMIVSRGLGNSIIPQRVFNRPEIVVVQLN"
     gene            3194..3445
                     /locus_tag="EXW32_RS12490"
                     /old_locus_tag="EXW32_12815"
     CDS             3194..3445
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000548597.1"
                     /locus_tag="EXW32_RS12490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12815"
                     /product="hypothetical protein"
                     /protein_id="WP_002017002.1"
                     /transl_table=11
                     /translation="MHKEFEIEEYTAIEEQIHYYSTSLLVSHPEQIVKYLEKRLEKYAE
                     TLQYAHLYPETVILPIQQIVIEYSLDVARIRRYLNLKT"
     gene            3630..4355
                     /locus_tag="EXW32_RS12495"
                     /old_locus_tag="EXW32_12820"
     CDS             3630..4355
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016129461.1"
                     /locus_tag="EXW32_RS12495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12820"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_033729440.1"
                     /transl_table=11
                     /translation="MQQPSIILRDVSKKFGKKEVLHNLSLQVEKAEIFGLVGPSGSGKT
                     TLIKMIAGINESTTGDVIVFNTNMPNLNEMKRIGYMAQADALYEELSAYENADFIATMY
                     GLKGKRKKERIVEVFEFLQLSDHAKKQVQHFSGGMKKRLSLAIALLHEPEILILDEPTV
                     GIDPLLRKSIWEKFYDLKKKGTTIIVTTHIMDEAEFCERLGLIREGNLVAIGTPEELKK
                     QTSSGRIEDVFMLEGVIES"
     gene            4352..5371
                     /locus_tag="EXW32_RS12500"
                     /old_locus_tag="EXW32_12825"
     CDS             4352..5371
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161721.1"
                     /locus_tag="EXW32_RS12500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12825"
                     /product="ABC transporter permease"
                     /protein_id="WP_002127488.1"
                     /transl_table=11
                     /translation="MRVNGVVIRIIRQFFRDKRSLAMMFGAPMLLLWLLSLIFTQKDYI
                     PHIAVVDVPAPIVKAMKNQEASIYEYSKDKAISELEKQKVDAVIHLENGKMNLLLEGSD
                     SSKNRAVLQVLQKSTEKNNVSMMKPEVDYLHGSKDITMFDGLGPVLIGFFTFFFVFILS
                     GVSFVRERLSGTLERLLSTPVRRWEIVLGYIIGFGIFALIQSIIIVSFSVYILDLYVAG
                     SIWLTLLITCMLSLTALTLGTFLSAYANNEFQMIQFIPLVIVPQVFFSGLFPMESMNTW
                     LQMLGKLFPLTYGADAMRQVMIRNQGFTEIALDLTVLLLFSLLFAVGNVFALKKHRKI"
     gene            5396..6049
                     /locus_tag="EXW32_RS12505"
                     /old_locus_tag="EXW32_12830"
     CDS             5396..6049
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002161720.1"
                     /locus_tag="EXW32_RS12505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12830"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_002032224.1"
                     /transl_table=11
                     /translation="MKKDWLEELVAATNADKRNERQMRILEAAVDMFGEKGYASTSTSE
                     IAKRAGVAEGTIFRYYKTKKDLLFAVVMPTLTKFAAPFFVQAFAKEIFKTEYESYEVLL
                     RVIIQNRFEFAKKHFPMIKILIQEVPFQPELKSEIQQLIETELLVHFKKLIAKFQEEGE
                     IIELPPSSVLRLTLSAVLGLLLTRFLLLPEEKWDDEVEIENTIQFILYGLTPRR"
     gene            6054..7022
                     /locus_tag="EXW32_RS12510"
                     /old_locus_tag="EXW32_12835"
     CDS             6054..7022
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001248633.1"
                     /locus_tag="EXW32_RS12510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12835"
                     /product="DUF523 and DUF1722 domain-containing protein"
                     /protein_id="WP_002127490.1"
                     /transl_table=11
                     /translation="MRQFAKPIIVVSKCLEFDACRYNGEMVPDLTIRNLQPFVTFIPVC
                     PEVEIGLGTPRETIRIVEKNGANRLVQPSIREDVTEKMNEFSNAFLQTLPEVDGFILKN
                     RSPSCGTRDVKIYSGFEKGPVKGKGTGLFGGAVIKKFSHLPIEEEGRLSNFIIREHFFT
                     RLFTIAHYKMIKHTKNIKELVAFQSDYKYLFMAYNQVKQKELGRIIANQKNETIEVVFD
                     NYEKTLYELFIRAPRYTSNVNVCEHIFGYFKTKLKKQEKDHFLELLQKYSEKKIPLSSL
                     LVILKTWAIRFDEKYLLRQTYFEPYPEGLVEISDSGKGRDY"
     gene            7239..8384
                     /locus_tag="EXW32_RS12515"
                     /old_locus_tag="EXW32_12840"
     CDS             7239..8384
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001980414.1"
                     /locus_tag="EXW32_RS12515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12840"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_002032227.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 5.3e-39, bitscore:
                     131.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 3.8e-26, bitscore:
                     89.4, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 1.8e-57, bitscore:
                     192.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFTLTREKQMIKEMVRDFAEKEIAPKAVYYDKTAEFPYETFQKM
                     GELGLLGIPFPEEYGGSGGDTLSYALAVEEIGRACGGTGLSYAATISLGASPIYYFGTE
                     EQKQKFLVPMASGKTLGAFGLTEPNAGSDAGGTQTKAILDGDEYVISGEKCWITNAEYA
                     NTIIVTAINGFEDNGKKRISAFIVPTTSEGLTISSPYDKMGVRASNTCEIVLDGVRVPK
                     ENILGDVNKGFKQFLYTLDGGRISIAALAVGIAQSAFERALQYAKERQQFGKPISNFQA
                     IQFKLADMATEVELARNLVHKAAWLKDNDKPFGKEAAMAKLFASEAASRIANHAVQIHG
                     GYGYMREYEVERYIRDAKLLEIGEGTSEIQRLVIARHLGCR"
     gene            8400..9737
                     /locus_tag="EXW32_RS12520"
                     /old_locus_tag="EXW32_12845"
     CDS             8400..9737
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000486723.1"
                     /locus_tag="EXW32_RS12520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12845"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_215586045.1"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 2.6e-10,
                     bitscore: 38.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.5e-06, bitscore:
                     25.4, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 2.9e-06, bitscore: 25.3,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.6e-09, bitscore:
                     34.3, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQKILIANRGEIAVRIMKTCQKLGIRTVAIYSVADENALHVKLA
                     NEAYLVGGPRVQESYLNLEKIMEIAKKTNAEAIHPGYGLLSENPSFPIRCKEEGIVFIG
                     PSEEIITKMGSKIESRIAMQAADVPVVPGITTNIETAEEAIEIAKQIGYPLMLKASAGG
                     GGIGMQLMETEQTLTKAFESNKTRAQNFFGNGEMYLERYIADAHHIEIQLLADTHGNTV
                     YLWERECSVQRRNQKVIEEAPSPFLDEGTRKAMGEVAVQAAKALGYTNAGTVEFLVDDQ
                     KNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLLIAYGEKLSFTQDDVKRSGHAIEARIY
                     AEDPKTFFPSPGKITDLTLPTNIRIDHFLENQVTITPFYDPMIAKVIAHGETREEAISK
                     LKIALEELKVEGIKTNTPMLLQVLGDDVFKSGIYTTGFVTKQLVKK"
     misc_feature    8443..8457
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 22.62"
                     /tool="antismash"
     gene            9764..9979
                     /locus_tag="EXW32_RS12525"
                     /old_locus_tag="EXW32_12850"
     CDS             9764..9979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001987345.1"
                     /locus_tag="EXW32_RS12525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12850"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein subunit"
                     /protein_id="WP_001985297.1"
                     /transl_table=11
                     /translation="MMTKVYASMAGNVWKIVVGVGDTVEEEQDVVILESMKMEIPIVSE
                     EAGTVMKINVQEGDFVNEGDVLLEIE"
     gene            10001..10912
                     /gene="mvaB"
                     /locus_tag="EXW32_RS12530"
                     /old_locus_tag="EXW32_12855"
     CDS             10001..10912
                     /EC_number="4.1.3.4"
                     /codon_start=1
                     /gene="mvaB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017149491.1"
                     /locus_tag="EXW32_RS12530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12855"
                     /product="hydroxymethylglutaryl-CoA lyase"
                     /protein_id="WP_002017011.1"
                     /sec_met_domain="HMGL-like (E-value: 8.7e-49, bitscore:
                     164.7, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPNFAVIKEVGPRDGLQNEKKIVGTKDKVKWIQLLTEAGLSYV
                     EVSSFVHPKWVPALADASDVFSELKRDPNVTYAALVPNQNGLERAFLQNVDEVNVFLSA
                     SESHNKSNINKSIKEALAVIEDITKQATFEGKKVRGYVSTVFGCPYEGDISATAVDEIC
                     NQLFSYGIYEVSLGDTIGVANPLQVEQVLEHLLKKYDASQFAMHFHNTYGMALANVVKS
                     LEYGITTFDSSCGGLGGCPYAPGASGNVATDDLVHMLHKLGVQTNIDEEKLLRASQFIQ
                     SKLNIQLPSHVYRALQHKTISR"
     gene            10917..11705
                     /locus_tag="EXW32_RS12535"
                     /old_locus_tag="EXW32_12860"
     CDS             10917..11705
                     /EC_number="4.2.1.17"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: ECH (14-254). E-value: 4.4e-75. Score:
                     244.1. Matches aSDomain:
                     nrpspksdomains_EXW32_RS12535_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001990763.1"
                     /locus_tag="EXW32_RS12535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12860"
                     /product="enoyl-CoA hydratase"
                     /protein_id="WP_002017012.1"
                     /transl_table=11
                     /translation="MLQLQNISVDYVTPHVVKISLNRERQANSLSLALLEELQTILTQI
                     NEESNTRVVILTGDGEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIA
                     AINGIALGGGTELSLACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKEL
                     IYTGRRISAQEAKEYGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQV
                     DLHTGLQMEKQAYEGVIHTKDRLEGLQAFKEKRKPMYKGE"
     aSDomain        10959..11678
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW32_RS12535_ECH.1"
                     /evalue="4.40E-75"
                     /label="EXW32_RS12535_ECH.1"
                     /locus_tag="EXW32_RS12535"
                     /protein_end="254"
                     /protein_start="14"
                     /score="244.1"
                     /tool="antismash"
                     /translation="HVVKISLNRERQANSLSLALLEELQTILTQINEESNTRVVILTGD
                     GEKAFCAGADLKERANMSEEQVRHAVGMIRSTMEMVEQLPQPVIAAINGIALGGGTELS
                     LACDFRIASDTASLGLTETSLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKE
                     YGLVEFVVPADLLEEKAIEIADRIAKNGPIAVRLAKEAISNGIQVDLHTGLQMEKQAYE
                     GVIHTKDRLEGLQAFKEK"
     gene            11708..13249
                     /locus_tag="EXW32_RS12540"
                     /old_locus_tag="EXW32_12865"
     CDS             11708..13249
                     /EC_number="6.-.-.-"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012094296.1"
                     /locus_tag="EXW32_RS12540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12865"
                     /product="acyl-CoA carboxylase subunit beta"
                     /protein_id="WP_002017014.1"
                     /transl_table=11
                     /translation="MLDQKQQSNSFEERVETIKQGGAPKYHEQNKAKGKLFVRDRLALL
                     FDNGEYVEDALFANCEQTGLPADGVVTATGKIHGRTACVMANDSTVKAGSWGARTVEKI
                     LRIQETAEKLRVPLFYLVDSAGARITDQVEMFPGRRGAGRIFYNQVKLSGKVPQICLLF
                     GPSAAGGAYIPAFCDVVMMVEGNASMYLGSPRMAEMVIGEKVTLEEMGGARMHCSVSGC
                     GDVLCKTEEDAITQARQYISYFPSNYLEKTPLITPQEPKQFDKTLEEIIPENQNAPFNM
                     KDLINRIIDEGSFFEVKKLFAQELITGLARIDGKPIGIIANQPRMKGGVLFHDSADKAA
                     KFINLCDAYHIPLLFLADVPGFMIGTKVERAGIIRHGAKMISAMSEATVPKISIVVRKA
                     YGAGLYAMAGPAFEPDCCLALPTASIAVMGPEAAVNAVYANKIAALPEEERASFIAEKR
                     EEYKKDIDIYRLASEMVIDGIVHPNNLREELKGRFEMYMSKYQVFTDRKHPVYPV"
     gene            13298..15238
                     /locus_tag="EXW32_RS12545"
                     /old_locus_tag="EXW32_12870"
     CDS             13298..15238
                     /NRPS_PKS="Domain: AMP-binding (95-521). E-value: 2.4e-82.
                     Score: 268.6. Matches aSDomain:
                     nrpspksdomains_EXW32_RS12545_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017560287.1"
                     /locus_tag="EXW32_RS12545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12870"
                     /product="AMP-binding protein"
                     /protein_id="WP_002127493.1"
                     /sec_met_domain="AMP-binding (E-value: 2e-87, bitscore:
                     291.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQAVWFPTEEYKEKTRLFGWMKSLGYEDYEAFYNKSIEETAWFW
                     GEAERAVGYQWMKPYTEVLDLENGTPFAQWYTEGTCNVVESALSRWLADDKTKTQAALM
                     YEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGDRVTIYMPMIPETVVAMLAVMKIG
                     AIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRRGKIVSLKDEVDKACEHCPTVEKV
                     VIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNSDDPLMLIYTSGTTGKPKGTVHTH
                     AGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPFLLFGSLINGATMVMYEGVPDFPE
                     ADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNKHSLKSLEVFASTGEPWNPDPWMW
                     LFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAPISFNASLPGMAAVVLDDQGKPIR
                     DEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFENKWVHGDWVIYDGEQYIITGRSDD
                     TLNIAGKRIGPAEYESILVKHNDVIEAAAVGVPDDVKGEVCHCFVVLRDGVTFSGELKK
                     ELMSLVNSHIGKALCPKDIHVVEDLPKTRNSKVMRRVIKAAYLGKELGDLSSLVNPEVV
                     PFIQGLQSSKL"
     aSDomain        13583..14860
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EXW32_RS12545_AMP-binding.1"
                     /evalue="2.40E-82"
                     /label="EXW32_RS12545_AMP-binding.1"
                     /locus_tag="EXW32_RS12545"
                     /protein_end="521"
                     /protein_start="95"
                     /score="268.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="KTKTQAALMYEGENGTSKSFTYEELDSWVSRVANGLKHAGIEKGD
                     RVTIYMPMIPETVVAMLAVMKIGAIISPIFSGFAADAVMTRVQAAGSKMVITADGFSRR
                     GKIVSLKDEVDKACEHCPTVEKVVIVRHAGNDFTPHNYDFSWSTLEKEKPFIHAEEMNS
                     DDPLMLIYTSGTTGKPKGTVHTHAGFPLKSAFDAGFGMNIKQGDRVLWVTDMGWMMGPF
                     LLFGSLINGATMVMYEGVPDFPEADRLWETVDKYEITHLGISPTLIRALMAKGDEYVNK
                     HSLKSLEVFASTGEPWNPDPWMWLFNTVGKGKVPICNYSGGTEISGGIFGNVLIKPIAP
                     ISFNASLPGMAAVVLDDQGKPIRDEVGELCLEKPWVGMTKSFWEDDERYVNTYWSRFEN
                     KWVHGDWVIYDGEQYIITGRSDDTLNI"
     CDS_motif       14084..14140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW32_RS12545_0001"
                     /evalue="7.60E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="EXW32_RS12545"
                     /protein_end="281"
                     /protein_start="262"
                     /score="24.7"
                     /tool="antismash"
                     /translation="MLIYTSGTTGKPKGTVHTH"
     CDS_motif       14831..14893
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EXW32_RS12545_0002"
                     /evalue="7.80E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="EXW32_RS12545"
                     /protein_end="532"
                     /protein_start="511"
                     /score="12.3"
                     /tool="antismash"
                     /translation="TGRSDDTLNIAGKRIGPAEYE"
     gene            complement(15682..15879)
                     /locus_tag="EXW32_RS12550"
                     /old_locus_tag="EXW32_12875"
     CDS             complement(15682..15879)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002017016.1"
                     /locus_tag="EXW32_RS12550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12875"
                     /product="hypothetical protein"
                     /protein_id="WP_002017016.1"
                     /transl_table=11
                     /translation="MDKKDLLSQQLDPVSLDALNTPSKAQEQLQETSQEAHNSNKKDST
                     QALHGEDLPISDVYRTTNKQ"
     gene            16197..16412
                     /locus_tag="EXW32_RS29890"
     CDS             16197..16412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000237376.1"
                     /locus_tag="EXW32_RS29890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002085442.1"
                     /transl_table=11
                     /translation="MVIVTLAIVPGESRSEAVTVTVPGPLAARNTAVKLPEALVMTARG
                     TMKAREGLLNEKLTTTPGVGLPFTNT"
     misc_feature    16432..16449
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     gene            16458..16706
                     /locus_tag="EXW32_RS29895"
     CDS             16458..16706
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000254010.1"
                     /locus_tag="EXW32_RS29895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_252188975.1"
                     /transl_table=11
                     /translation="MVSLEVKVIEAGPAGRLNPVGPVGPVEPVGPVGPVGPVGPVEPVD
                     PVDPVEPVDPVGPVGPVEPVDPVEPVAPVEPVGPVGN"
     gene            complement(<16724..16780)
                     /locus_tag="EXW32_RS30320"
                     /pseudo=""
     CDS             complement(<16724..16780)
                     /GO_component="GO:0043592 - exosporium [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03720.3"
                     /locus_tag="EXW32_RS30320"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="exosporium leader peptide-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEFLYFAALNPGSIGPTL"
     misc_feature    complement(17030..17045)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            17604..19367
                     /gene="ltrA"
                     /locus_tag="EXW32_RS12560"
                     /old_locus_tag="EXW32_12885"
     CDS             17604..19367
                     /EC_number="2.7.7.49"
                     /GO_function="GO:0003964 - RNA-directed DNA polymerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000373 - Group II intron splicing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ltrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000108303.1"
                     /locus_tag="EXW32_RS12560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12885"
                     /product="group II intron reverse transcriptase/maturase"
                     /protein_id="WP_215586047.1"
                     /transl_table=11
                     /translation="MQKVFDDLYQRSKNNATKGINLYKHLISKENILLAYRNIKANTGS
                     KTEGTDGITIDHYKMEDVDFFVDNIRKNLVDYKPNTVRRVEIPKPNGKKRPLGIPTMRD
                     RLIQQMFKQVLEPICEAKFYKHSYGFRPNRSTHHAMARCQFLMNRGGYSHVVDIDIQGF
                     FDNVNHSKLLKQLYNIGITDRKVLTIISKMLKAPIKGIGIPTKGTPQGGILSPLLSNVV
                     LNDLDWWITSQWDNIKTRKTYTLPNKNYHLSKTKLKRMYIVRYADDFKIFTNNHKSATK
                     IFYAVEGYLKNHLNLDVSKEKSTITNLKRKSSDFLGFSIKFVKKRKRYVANTHVSEKKK
                     KDILEKAKTRIKAIQKSPSGKTIQDYNSYVLGIKNYYKIATHVSIDFTEIAFRLSKTLF
                     NRLKSIGKYKIPTNTNALYKRTHRNNYRTFEIAGNHVYPLADIQTRFPQSFSQDICNYT
                     KKGRQKLIKSLKGNIANEMQKMLLSSTKGKSMEYIDNRMSKYSMQNGKCAVTGIFLLAD
                     EAHCHHKVPKGMGGTDEFNNLIIVHEFVHRLIHAINEETIRTYMRILQLNDKQLKKINK
                     LRKACNLVTLV"
     gene            complement(19558..19926)
                     /locus_tag="EXW32_RS12565"
                     /old_locus_tag="EXW32_12890"
     CDS             complement(19558..19926)
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002189674.1"
                     /locus_tag="EXW32_RS12565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12890"
                     /product="septum formation initiator family protein"
                     /protein_id="WP_215586048.1"
                     /transl_table=11
                     /translation="MGNIPEISSQQSNPKIPSQQVNANTKQSNNKKARRRIITTLAFIL
                     PIIFVLQYSLNNQQEMIKEKQITVNTEQQKLSSLKKDGHSLKNDVKALTGSEEEILKFA
                     RKLYGFSKPNETIFQITE"
     gene            20256..20426
                     /locus_tag="EXW32_RS12570"
     CDS             20256..20426
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000284255.1"
                     /locus_tag="EXW32_RS12570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_003189371.1"
                     /transl_table=11
                     /translation="MYQGDHFITEGIILEVSEKANKSLYWRWCMLAPRYEKVCGNSTKR
                     LRLIRIDDDEE"
     misc_feature    20470..20483
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     misc_feature    complement(20471..20484)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.54"
                     /tool="antismash"
     gene            20593..20973
                     /locus_tag="EXW32_RS12575"
                     /old_locus_tag="EXW32_12895"
     CDS             20593..20973
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000450238.1"
                     /locus_tag="EXW32_RS12575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12895"
                     /product="hypothetical protein"
                     /protein_id="WP_002127497.1"
                     /transl_table=11
                     /translation="METSTFLGLFWGWITVIVSGILFVRPSVLRELKKLVVEDRGFGIM
                     YGFLSIFLGLGSVILHNVWVFNWQGFLTVIAWLALLKGIYIIAYPEPSKKTDFELRVLS
                     TRIALAIIGALALWMLIVIYIK"
     gene            complement(21081..21383)
                     /locus_tag="EXW32_RS12580"
                     /old_locus_tag="EXW32_12900"
     CDS             complement(21081..21383)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EXW32_RS12580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EXW32_12900"
                     /product="hypothetical protein"
                     /protein_id="WP_170935234.1"
                     /transl_table=11
                     /translation="MKGGIKECPGKMIAGVLRKSIVVMTGGNLKKRIIVMMIGVLRKSI
                     VMMIGGNLKKRIIVIMIGVLNEISVVVNVSLFVVIVKEKVGNIFNIDLKERTCLL"
     gene            21845..22201
                     /locus_tag="EXW32_RS12585"
                     /old_locus_tag="EXW32_12905"
     CDS             21845..22201
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002032241.1"
                     /locus_tag="EXW32_RS12585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12905"
                     /product="hypothetical protein"
                     /protein_id="WP_002032241.1"
                     /transl_table=11
                     /translation="MGSRFNNCRKKCTCKHDDCWDIFEECKKEKNEKCDSSCVQGIRDE
                     LKKLINKTVRINTEGRTYIGTVSSVTCDVVKLAAIPGSVAAIISLCKIEAILPPATTVT
                     DEFDFNGVDVANKD"
     gene            22326..22838
                     /locus_tag="EXW32_RS12590"
                     /old_locus_tag="EXW32_12910"
     CDS             22326..22838
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127499.1"
                     /locus_tag="EXW32_RS12590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12910"
                     /product="GNAT family protein"
                     /protein_id="WP_002127499.1"
                     /transl_table=11
                     /translation="MIKLKQFTRSDFKQLINWINSEEFLIQWSGNAFTYPLNEQQLEKY
                     TECANTLAFKIMDEETKAVIGHISLGQIDNINKSARIGKVLVGNTKMRGRSIGKHMMKA
                     VLCIAFDELKLHRVTLGVYDFNKSAISCYEKIGFVKEGLLRESKRVGETYWNLWEMSML
                     EYEWNNK"
     gene            22888..23448
                     /locus_tag="EXW32_RS12595"
                     /old_locus_tag="EXW32_12915"
     CDS             22888..23448
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002127500.1"
                     /locus_tag="EXW32_RS12595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12915"
                     /product="hypothetical protein"
                     /protein_id="WP_016127014.1"
                     /transl_table=11
                     /translation="MNKKTKIISIAAVSGGGKTTITESLAHELKKSKALYFDRYKFDNC
                     PVDICKWIDDGANYDEWVLTPLMNDIQRSIQDSSLDYIIVDYPFAYLNREVGKFIDVTI
                     FIDTPLDIAMARRILRDFKEDTMSEIHNNLKHYMTHARKAYLEAIHTVKPNSDIVLDGS
                     LSISEIIDQIIEELNRREVIVNG"
     gene            <23469..23702
                     /locus_tag="EXW32_RS12600"
                     /old_locus_tag="EXW32_12920"
                     /pseudo=""
     CDS             <23469..23702
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000288270.1"
                     /locus_tag="EXW32_RS12600"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12920"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="KSLSDLYRRELDNFLQLWSGDFESKILKASWTDKTYKYGEVLMHV
                     IVHEIHHIGQISIWARELNLQPVSANLVGRGL"
     gene            complement(23761..24777)
                     /locus_tag="EXW32_RS12605"
                     /old_locus_tag="EXW32_12925"
     CDS             complement(23761..24777)
                     /GO_function="GO:0008800 - beta-lactamase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030655 - beta-lactam antibiotic catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001160038.1"
                     /locus_tag="EXW32_RS12605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EXW32_12925"
                     /product="serine hydrolase"
                     /protein_id="WP_002185782.1"
                     /transl_table=11
                     /translation="MQFLKKITVLLLSFLITALIVLYFYLYVNGPIIQAKSAILIDTNS
                     GEIVYKKNEETPIQSATLSKLMTEYIALEQLNEGKIQLDELVKISNEVFRAETSPIQVT
                     SKDKTTVRDLLHALFLTGNNRSALALAEHIAGNEDNFTLLMNDKAKQLKLSQPSPFLNA
                     TGINNDTNKQSTTTSIDVAKLATQLVKDFPDVLNVTKLTSYQFTFKDSKVFNTNKMIYS
                     LNKNIKLQGVDGLQTSFSTNGNYSFVSTATRGDTRLISVILDAGDENSTFIETKKLLQY
                     GFDPSSYSALQAFKDAVTSWTILFQFKNLIIQMIMIFFIITILMFLYIRQKKAEDFN"
ORIGIN
        1 cggatcccaa aaataggaag aattaaggtc tttgtattta ttaagtattt cctcgaatga
       61 tagtgagcca ctttcaggag tagtttcttc ttttaagcgc attaaaattg tttctgtagg
      121 atgatctttt aaaaattgaa ttgcctcttt taatacatct tcaaacattg ctttttgatt
      181 tacaatccca tggtacattg caaaagaatc ttttacacgt ttaacacgca tatctacata
      241 tcgaattccg gaatttaatt gttgtggtag actcatagtt tgatttcttg tcaaattttc
      301 atcaagaaaa cttgctccat gtaaagccat tgtaccgtga gtccctggaa tagatatttc
      361 actcaatttt gttgaatctg ctactttcga catccatgct gggttttgat agcctatatt
      421 ggattcatag gaataacctg gatgactatc agcaaaaata gtagatggtg tacttaaact
      481 tgctagtgtg aaacaagtaa ggatactaat tttaaaaaaa ttcctcattt ttattttgtt
      541 cattttatct ctcctgactt ttaaacaata gatataataa aacaagatga tttttaacta
      601 catctattgt tttcattctt aaagtaatga atttttgtgt ttgaaaaaat caaaataggg
      661 taggaagtta tttgagattt taatagtttg ttgtaataaa ttgtatctaa tagtcaaacg
      721 gattcttaaa gaattgaagc atagatgggt aaaaaacaaa ctttccgctg tactgtatac
      781 aaacaaaaca gaagtcttaa aaaagacttc tattttgtga catataatga atgataaggt
      841 ggttaacaaa tcaagataat gtgactgagt ggtaaaaatc tatttatagc tgtttcagaa
      901 tttcttataa caaggctact taggaaaagt ggatctctac aatgctaata aaaatttaaa
      961 aattctattc attaaaactt aaactaacta cagttgcgat agattgggct gcatgttccc
     1021 agcttccatc tataactttc ccaatttgtt gaccaagtgc atttaaatca tttggattta
     1081 ctgggatccc attatacgca gcaagaattg ataaaagtgg agcagtaaat ggtgtccaac
     1141 cacctctatc aatattaaat acaggcttat ctattacctt tccatcttgc actgtaaact
     1201 cataataaaa ttgatcatct ggacgaaaac ttaaatgatg agaaatttgt cccttaacat
     1261 atgttttacc gccacctaaa tttactactt caattggttt tacattaaat tcatgctcaa
     1321 atactttaat ttttttaact tctggaccat ttaaggcagc tttaactgct gtttccaaat
     1381 tattttgtgc aaatggttga atactcatct gtatctcttc ttgttggata ggagcctcta
     1441 tttcagcagc aaacaccgat gtacttggta gtgcacctgt agccaatgta gctgcaagtg
     1501 ctgtcgtcat catgattttt cttttcatct tcatagtttt cttcctccct taaagttatg
     1561 atatataatt ttttaaagac tgacatgggg caatatttta tttcataatg cacgcaaaaa
     1621 aatagtttaa gaattatgtg aaattatgtc agaaaattaa agttaattat atatgcactt
     1681 acaatgatag ctatctacac atgttttttc aattttctaa taaataatac agtaatacct
     1741 tttcataagg caatttagtg tttcaattct ctctttgtac gttttaaaca aattaaaatc
     1801 gtagtggtaa taatatattt gtaatcaaat gtcgtatata cttcgagaaa agtacacaat
     1861 atttttataa aaaactatag gaattatcat gatatagtta tcaaacgaag taagataaat
     1921 gttaatatta tgaagagatt ccagtgatct gctataaagt tactgagaaa tgagcatgac
     1981 atcatacacg catgcgattg aaaaatttta taagtggcgt ataaaactat aacaaatact
     2041 acaaatcaat taaaaaattt cagttattct gaatgcgaag ggcacgtaat atttattgtg
     2101 aactgtagta ctgattaaga ttttaggagg aagtatgaac aagaagatta aaagaatcat
     2161 attaattatt ggtatattag taggcattag tatcttttta tatttacaaa acaatttaat
     2221 aagtataact gaggttaaaa taacctctag taaaattccc tcttctttta aaggatataa
     2281 aatactacaa atttcagatt tacataataa aaaatttggt gataatcaag acgttttaat
     2341 tcaaaaagta aaaagcataa atccagatat tattgctatt acgggtgatt taatagacag
     2401 taaatcgtac gatgcagaaa tgagtatgca agtaatacga gaacttgtga aggaatatcc
     2461 ggtatatttt gtgacaggaa atcatgaaaa atggtcaggg aaatataaca gtttagaaaa
     2521 aaaattaaag aaacagcatg tcactgtttt aagaaatgaa catgtaataa tacaaaaggg
     2581 aggacacgaa ataaacttgt taggaattga tgatccggaa tttaatactg gagatattga
     2641 tgaaggaagt attgtaaaag atgcaattgt aaaagcaaaa attgaaacgc tgccagatag
     2701 gtataatgta ttattatccc ataggcctga atttttagaa gcatatgctg atgagcaagt
     2761 agatttagtg ttatcgggtc atgcacatgg ggggcaagtt cggttacctt ttatcggggg
     2821 attagttgct cctaatcaag gaatactgcc caaatataca gcgggtttat atgaacaaca
     2881 aaatacgtct atgatagtta gtagaggatt aggcaatagt atcattccgc aaagagtttt
     2941 taatagacct gagattgtag tcgtgcagtt aaattaatct gtacggcttt tttgttcagg
     3001 agaataattt aaaggtagtt tttcttgagt acaagtttcc attacaattt tgttaaaatt
     3061 tttcaacgtt acataaagta acaaaatttg acctattgag tttgttatag tgtaaataat
     3121 caaaaaactt aaaaattagt cgagttaaaa tagttattat taagcaatat taaaaatata
     3181 aaggggtgta caaatgcata aagaatttga aattgaagaa tatacggcga ttgaggagca
     3241 aattcattat tatagtacgt ctttattagt aagtcatcct gagcaaattg taaagtattt
     3301 agaaaaacgg ttggaaaagt atgcagaaac gttacaatat gcacatttat atccggaaac
     3361 ggttatatta ccaatacagc aaatagttat cgaatattca ttagatgttg ctagaattag
     3421 aaggtattta aatttaaaaa cataacaaaa atcaaataat ttacaatgaa acagagtcga
     3481 ctttaagaaa agatattcta atgtcgactc tgtttcattg atttagtaaa taacagaaaa
     3541 aatatatgtt tgaaaagttt gacatataat aattcgagag taaaataaaa gtgagtactc
     3601 actcatttta aagaaaaggg ggatttttag tgcagcaacc ttcaattatt ttacgagatg
     3661 tatcaaaaaa atttgggaaa aaagaagttt tgcataacct ttcgctgcaa gtagaaaaag
     3721 cagaaatttt tggcttggtt ggaccttccg gatcagggaa aacaacactc attaaaatga
     3781 ttgcaggtat taatgagtca actacagggg atgtaattgt ttttaataca aacatgccta
     3841 atctaaatga aatgaaaaga attggttata tggctcaggc tgatgcatta tacgaagaac
     3901 tatcggcata tgaaaatgca gattttattg caacgatgta tgggttaaaa ggtaagcgta
     3961 agaaagagag aatcgtagaa gtttttgaat ttttgcaatt atcagatcat gcgaaaaagc
     4021 aagtacagca tttttcaggt ggaatgaaaa aacgtttatc attggcgata gcactccttc
     4081 atgaaccaga aatattaatt ttagatgagc caacagttgg gatagatcct ctacttcgaa
     4141 aatcgatttg ggagaagttt tatgacctta aaaagaaagg aacaactatt attgtaacaa
     4201 cgcacattat ggatgaagct gagttttgcg aacgtctagg gctaattaga gaagggaatt
     4261 tagttgcgat tggcacaccg gaggaattga aaaaacaaac atcttctgga cgaattgaag
     4321 atgtctttat gttagaagga gtgattgaat catgagagtt aatggtgtag tcatccgtat
     4381 cattcgtcaa ttttttcgag ataagcgttc tttagcaatg atgtttgggg caccaatgtt
     4441 attactttgg ttattatcgc taatatttac acaaaaagac tatataccgc atattgctgt
     4501 agtcgatgta cctgctccta tagtaaaagc aatgaaaaat caagaagcat caatttatga
     4561 atatagtaaa gacaaagcaa tttcggaatt agaaaagcaa aaggtagatg cagtaattca
     4621 tttagaaaat ggaaaaatga atcttctatt agaaggcagt gattcatcaa aaaaccgtgc
     4681 agtacttcaa gtattgcaaa agagtacaga gaagaataat gtatcaatga tgaagcctga
     4741 agtggattat ttacatggct ctaaagacat tacgatgttc gatgggcttg gtcccgtatt
     4801 aattggtttc tttacatttt tctttgtatt tatattgtcc ggagtatctt ttgtaagaga
     4861 acgtttaagt ggtacattag agaggttatt gtccacacca gtgagaagat gggaaatagt
     4921 tttaggatat attattggtt ttggaatctt tgcacttata caatctatta taattgtaag
     4981 tttttcagtt tatattttag atttatatgt agctggctca atatggctaa cgctacttat
     5041 aacatgtatg ctttctttaa ctgcactaac attaggcaca tttttatcgg catacgcaaa
     5101 taatgaattt caaatgattc aatttatacc gcttgttatc gtgccacaag tcttcttttc
     5161 tgggttgttt ccaatggaat ccatgaatac atggttacaa atgttaggta aattatttcc
     5221 actcacatat ggtgctgacg ctatgagaca agtaatgatt cggaatcaag ggtttacaga
     5281 gattgcatta gatcttactg tattactact tttttcacta ttatttgcag taggaaatgt
     5341 atttgcatta aagaaacatc gcaaaatata atgatgataa aaaggagcac aataaatgaa
     5401 gaaggattgg ctggaagaat tagttgccgc aacgaatgct gataaacgta atgaacgtca
     5461 aatgcgtata ttagaggcag ctgttgatat gtttggagaa aaagggtacg cctcaacttc
     5521 aacgagtgaa attgcaaagc gagctggtgt agcggaagga acaatcttcc gctactataa
     5581 aacgaaaaaa gatttattgt ttgcagtcgt gatgccgacc ttaacaaagt ttgctgcacc
     5641 atttttcgta caagcctttg caaaagaaat atttaaaaca gagtatgaat cgtatgaagt
     5701 gcttttaaga gtaataattc aaaatagatt tgaatttgct aaaaagcact ttccaatgat
     5761 aaaaatatta attcaagaag taccatttca gccggaacta aaaagtgaaa tacaacaatt
     5821 aatagaaaca gaactgcttg tacattttaa aaagctgatt gcaaagtttc aagaagaagg
     5881 ggaaattatt gaacttccac catcttccgt attacgtctt actttatcag ctgtattagg
     5941 gttgctctta acgaggtttt tattattgcc ggaagagaaa tgggacgatg aagtggaaat
     6001 tgaaaatacg attcaattta tattgtatgg actaacgcca cggaggtaat gtgatgcgac
     6061 aatttgctaa accgataatt gttgtaagta aatgtttaga atttgatgcc tgtcgttata
     6121 atggagagat ggttccagat ttaacaattc gaaacttgca gccatttgtt acatttatac
     6181 ctgtatgtcc tgaagtagaa attggtttag ggactcctcg tgaaacgata cgtattgtag
     6241 aaaaaaatgg tgcgaatagg cttgtacaac cgtcaatacg agaagatgta actgaaaaaa
     6301 tgaatgaatt ttcaaatgca tttttacaaa cattacctga agttgacggt tttattttga
     6361 agaatcgttc gccaagttgc ggaactcgtg atgtgaaaat ctattctggt tttgaaaaag
     6421 ggccagtaaa aggaaaagga actggattat ttggtggagc agtaataaaa aaattttcgc
     6481 atcttccaat tgaagaagaa ggtagattgt cgaattttat tattagagag catttcttta
     6541 caagattgtt tacaatcgcg cattacaaaa tgattaaaca tactaaaaac ataaaagaac
     6601 tcgtagcgtt tcaatcagat tataagtatt tatttatggc atataatcag gtgaaacaaa
     6661 aagaattagg gcgtattatt gcaaatcaaa aaaatgaaac aattgaagtc gtatttgata
     6721 actatgagaa gactttatat gaattattta ttcgcgcgcc tcgctataca tcgaatgtaa
     6781 atgtatgtga gcacattttc ggatatttta aaacaaagct aaaaaaacaa gaaaaagatc
     6841 attttttaga gctgttacag aagtattctg aaaagaaaat cccacttagt agtttacttg
     6901 tcattttaaa aacatgggcc attcgatttg atgaaaagta tttattaaga caaacatatt
     6961 tcgaaccata ccctgaaggg ttagtagaaa tttctgattc gggaaaaggt agagattatt
     7021 aaacaataaa ttacataatt cgacacaaaa cctcctatgt tgttgtagaa caatgtagga
     7081 atttttttgt gcattggtac agaatctgtt ttaaaattaa gttatgacag aattatagca
     7141 attgtctaac taatattcgt gtcttttaag aagtaatgtt tgtagtagaa actcgcacgc
     7201 tgtcgaaact caatattcga taaggggtgt gtagcggaat ggaatttact ctaactcgcg
     7261 aaaaacaaat gattaaagaa atggtacgtg attttgctga aaaggaaatc gcaccgaaag
     7321 ctgtatatta tgacaaaact gcggaatttc catatgaaac atttcaaaaa atgggcgaac
     7381 taggattatt aggtatccca ttcccggaag agtatggagg ttcaggtggc gatacgttat
     7441 cgtacgcgtt agctgttgaa gagattggtc gtgcttgtgg tggaacaggt ttaagctatg
     7501 ctgcaacaat ttcattaggt gcttctccaa tttattattt cggtacagaa gaacaaaaac
     7561 agaaattttt agttccaatg gcgtcaggta aaacgttagg tgctttcgga ttaacggagc
     7621 caaatgctgg atctgatgca gggggcacac aaacgaaagc aattttagat ggcgatgaat
     7681 atgttattag tggtgaaaag tgctggatta caaacgcaga gtatgcaaat acaattattg
     7741 taaccgctat caacggtttt gaagacaatg gtaaaaaacg tatttctgca tttatcgtac
     7801 cgactactag tgaaggatta acgatttcaa gcccttacga taagatgggt gttcgtgctt
     7861 ctaatacttg tgaaatcgta cttgatggtg tacgtgtacc gaaagaaaat attcttggtg
     7921 atgtaaataa aggatttaaa caattcttat atacacttga tggaggacgt atttcaattg
     7981 cagcattagc agtaggtatt gcacaatctg catttgaacg tgcattgcaa tatgcgaaag
     8041 aacgtcaaca atttggaaaa ccgatttcta atttccaagc gattcaattt aaattggctg
     8101 atatggcgac tgaagtagaa ttagcgcgta atttagtaca taaagcagct tggttaaaag
     8161 ataacgataa acctttcggt aaagaagcgg ctatggcaaa gttgtttgca tctgaagctg
     8221 caagtcgtat agcaaatcat gcagtacaaa ttcatggtgg atatggctat atgcgtgaat
     8281 atgaagttga acgatatatt cgtgatgcaa aacttttaga aattggtgaa ggaacttctg
     8341 aaattcaacg tctcgtaatt gcaagacatt taggatgtag ataaaaagga ggagtcacta
     8401 tgtttcaaaa aatattaatt gctaatcgcg gggaaatcgc agttcgcatt atgaaaactt
     8461 gtcaaaaact tggcattcgt accgttgcta tttattctgt ggctgatgaa aatgcccttc
     8521 atgtaaaatt ggcaaatgaa gcttacttag taggcggtcc acgtgtccaa gaaagctatt
     8581 taaaccttga aaaaattatg gaaatagcta agaagacaaa tgctgaagca atccatccgg
     8641 ggtacggatt attatcagag aatccatctt ttccgattcg ctgtaaagaa gaaggcatcg
     8701 tatttatcgg tccttcagaa gaaatcatta ctaagatggg aagtaaaatt gagtcacgta
     8761 tagcgatgca agcagcagat gtaccagtag ttccaggcat tactacaaat atagaaactg
     8821 ctgaagaagc aattgaaatt gcaaaacaaa ttggttatcc attaatgctt aaggcatccg
     8881 cgggcggcgg aggcattgga atgcagttga tggaaactga gcaaacgctc accaaagcat
     8941 ttgaaagtaa taaaacaaga gcgcaaaatt tctttggtaa cggagaaatg tacttagaac
     9001 gctatatagc agatgcacat catattgaaa ttcagctttt agcagataca catggtaata
     9061 cagtgtattt atgggaacgc gaatgttcag tgcagcgccg aaatcaaaaa gtaattgaag
     9121 aagcaccttc accattttta gatgagggta cacgaaaggc tatgggagaa gttgctgtac
     9181 aagctgctaa agcacttggt tatacaaatg caggtacagt tgagtttctt gtagatgatc
     9241 aaaagaactt ttatttctta gaaatgaata cgagattaca agtagaacat ccagttacag
     9301 aagaaattac tgggttagac ttagttgaac aacaattact tatcgcatat ggtgagaagc
     9361 tatcatttac acaggatgat gtaaaacgta gtggtcatgc cattgaggct cgtatttatg
     9421 cagaagatcc gaaaacattc ttcccatcac ctgggaaaat tacagattta acgttaccga
     9481 caaatatacg tattgatcac tttttggaga atcaagtaac gattacacct ttctatgatc
     9541 caatgattgc gaaagtaatc gcacatggtg aaactcgtga agaagcgatt tcaaaattaa
     9601 aaattgctct agaagagtta aaagtagaag gtattaaaac aaacacacca atgttactgc
     9661 aagtactcgg agacgatgtg ttcaaaagtg gtatttatac aacgggtttt gtaacgaaac
     9721 aacttgttaa aaagtaagat ttatgaatat taagggggaa aaaatgatga cgaaagtata
     9781 tgcatcgatg gcaggaaatg tttggaagat tgttgtagga gtaggagata cagtagagga
     9841 agagcaggat gtcgtcattt tggaatctat gaaaatggaa attccaatcg tttcagaaga
     9901 agccggaact gttatgaaaa ttaacgtaca agaaggcgat tttgtaaatg aaggagatgt
     9961 attactagaa attgaatagg gagatatagg gggaagcgaa ttgaaactac ctaattttgc
    10021 tgtcattaaa gaagtcgggc cacgtgatgg cttacagaat gaaaaaaaga ttgttggcac
    10081 aaaagataaa gtaaaatgga ttcaactact tacagaagcg ggattgtcgt acgttgaagt
    10141 ttcctcattc gttcacccta aatgggttcc tgcattagca gatgcaagtg atgtgttttc
    10201 tgagctaaaa agggatccaa atgttacata tgcagcgctt gttccaaatc aaaatggttt
    10261 ggaacgagct tttttgcaaa atgtagatga ggtgaatgtt tttttatcag caagtgaatc
    10321 tcacaataaa agtaatatta ataaatctat taaagaagca ttagctgtaa ttgaagatat
    10381 aacaaaacag gcaacgttcg aaggtaaaaa ggtaagaggc tatgtttcta ctgtatttgg
    10441 atgtccttat gaaggggata taagtgccac agcagttgac gaaatatgta atcaactatt
    10501 ttcatacggc atttatgaag tttctctcgg tgacacgatt ggtgtagcga atccattaca
    10561 agtagaacaa gtattagaac atctattaaa gaagtatgat gcttcgcagt ttgcaatgca
    10621 ttttcataat acgtatggaa tggctctggc gaatgtagtt aagtctttag aatatggtat
    10681 tacaacgttt gatagttctt gtggtggact cggaggatgt ccttatgcac caggagcatc
    10741 gggtaatgtt gctactgatg acttagtgca tatgctccat aagctgggag tccaaactaa
    10801 tattgatgaa gaaaagttat tgagagctag tcagtttatt caaagtaagt taaatatcca
    10861 attaccgagt catgtgtata gagcgcttca acataaaacg ataagtaggt gagaagatgc
    10921 tgcaattaca aaacatttca gttgactatg ttacaccgca cgttgtaaag atttcgttaa
    10981 atcgtgaaag acaagcaaac tcattatctt tggcattatt agaagaatta caaactatat
    11041 taactcaaat aaacgaagaa tcaaatacgc gcgttgttat tttaacaggg gatggcgaaa
    11101 aagcattttg cgctggtgct gatctaaaag agcgtgccaa catgagtgaa gaacaagttc
    11161 gccatgctgt gggtatgatt cgttctacta tggagatggt ggaacaatta ccacaaccag
    11221 ttattgctgc tattaatgga atcgcacttg gcggaggtac tgaattaagc ttagcttgtg
    11281 attttagaat tgcttctgac actgcaagtc taggtcttac tgaaacttct cttgcaatta
    11341 tacctggagc aggtggtact cagcgtttac cgagattaat tggagtcggt agagcgaaag
    11401 aattaattta tacaggaaga cgtatttcgg cgcaagaagc gaaagaatat ggtttagtag
    11461 aattcgtagt accagctgat ttactagaag agaaagcaat tgaaattgca gatcgaattg
    11521 ctaaaaatgg tccaattgct gttcgattag caaaagaagc aatttcaaat ggaattcaag
    11581 tagatttaca taccggctta caaatggaaa aacaggcgta tgagggcgta atccatacga
    11641 aagatagatt agaaggatta caggcattca aggaaaaacg caaaccaatg tataaggggg
    11701 agtaaatatg ttagatcaaa aacaacaatc taattcattt gaagaacgag ttgaaacaat
    11761 taagcaaggc ggggcaccga aatatcatga acaaaacaaa gcaaaaggga aactttttgt
    11821 tcgagatcgt ttagctcttt tattcgataa tggtgaatat gtggaagatg cattatttgc
    11881 aaattgtgaa caaactggat taccagctga tggtgttgta actgcgactg gtaaaataca
    11941 tggtcgtact gcgtgcgtaa tggcaaatga ttcgactgta aaagctggat catggggagc
    12001 acgtacagtt gaaaaaattc tacgaattca agaaacagca gaaaaattac gtgtaccgtt
    12061 attttattta gttgattctg ctggagcgcg tattacagat caagttgaaa tgttccctgg
    12121 acgccgcggt gcgggaagaa ttttttataa ccaagtgaaa ttatctggaa aagtgccaca
    12181 aatttgttta ttatttggac cttcagcagc tggtggtgcg tatattccag cattttgtga
    12241 cgttgttatg atggttgaag gaaatgcttc tatgtattta gggtctccgc gtatggctga
    12301 aatggttatc ggtgagaagg taactttaga agaaatgggc ggagcacgta tgcattgctc
    12361 agtatcagga tgcggagatg ttttatgtaa aacagaagaa gatgcaatta cgcaagcaag
    12421 acaatatatt tcttattttc caagtaacta tttagaaaag actcctttga ttacacctca
    12481 agaaccgaaa cagttcgata aaacgttaga agaaatcatt ccagaaaatc aaaatgctcc
    12541 tttcaatatg aaagatctca ttaacagaat tattgatgaa ggttctttct ttgaagtgaa
    12601 aaaattattt gctcaagaac taattacagg tttagcacgc attgatggta agccaattgg
    12661 cattattgca aatcagccgc gtatgaaggg cggcgtatta ttccacgatt cagctgataa
    12721 agcagcgaag tttataaatt tatgcgatgc ataccatatt ccattattat tccttgcaga
    12781 tgtacctgga tttatgattg gtacaaaagt agaacgtgcc ggaattattc gtcacggtgc
    12841 aaaaatgatc tctgcaatga gtgaagcaac tgtaccgaaa atttctatcg tcgttcgaaa
    12901 agcatatgga gctggcttat atgcaatggc aggtccagcg tttgaaccag attgctgctt
    12961 agcattacca acagcttcta ttgcagtaat gggtccagaa gcagcggtca atgctgtata
    13021 tgcaaataag atagcagctt taccagaaga agagcgtgca agctttattg ctgaaaaacg
    13081 agaagagtat aagaaagata ttgatattta ccgtttagca tctgagatgg tgattgatgg
    13141 tattgttcat ccaaacaatt tacgtgaaga gctaaaagga cgattcgaaa tgtatatgag
    13201 taaatatcaa gtattcacgg atcgtaaaca tcctgtatat ccagtttaaa agccctattt
    13261 agggctttct tgctcaaaaa atcaaggagg ggaaaacatg aaacaagcag tttggtttcc
    13321 aacagaagaa tataaagaaa aaacgcgttt atttggttgg atgaaatcat taggctatga
    13381 agattacgaa gctttttata ataagtcaat tgaagaaaca gcttggtttt ggggagaagc
    13441 tgagagagca gttggctatc agtggatgaa accatataca gaagtgttag atttagaaaa
    13501 tggtacaccg tttgcacagt ggtatactga gggaacttgt aacgttgtag aatctgcttt
    13561 atctcgctgg cttgcagacg ataaaacgaa aacacaagca gcacttatgt atgaagggga
    13621 aaacggaact tcgaaatcat ttacatatga agagcttgac agctgggtaa gccgtgttgc
    13681 caacggtttg aaacatgctg gtattgaaaa aggtgatcgt gtaacaattt acatgccaat
    13741 gattcctgaa acagttgttg ctatgttagc ggtaatgaaa attggagcga ttatttcacc
    13801 aatattctca ggttttgctg ctgatgcagt aatgacacgt gtacaagcag ctggttcaaa
    13861 aatggttatt accgcagatg gcttttcacg ccgtgggaaa attgtttcat taaaagatga
    13921 agtagataaa gcttgtgaac attgtccaac tgttgaaaag gtggtaattg ttcgtcatgc
    13981 aggaaatgat tttacaccgc ataattatga tttttcatgg agtacgttag aaaaagaaaa
    14041 accatttata catgctgaag aaatgaacag tgatgatcca ttaatgctta tatatacatc
    14101 tggaacgact ggtaagccga aggggacagt acacacacat gctggtttcc cgctaaaatc
    14161 tgcatttgat gcaggatttg gaatgaatat aaaacaaggc gaccgagtat tatgggtaac
    14221 tgatatgggc tggatgatgg gaccattttt actattcggc tctttaatta atggcgcaac
    14281 aatggttatg tatgaaggtg tcccagactt tccagaagca gaccgcttat gggagacagt
    14341 cgataaatat gaaattactc atctcggtat ttcaccaacg ttaatccgtg cattaatggc
    14401 aaaaggtgat gaatatgtaa ataaacactc gttaaagagt ttagaagtat tcgcatcaac
    14461 aggagaacct tggaatccag acccatggat gtggttattt aatacagttg gtaaaggtaa
    14521 agtaccaatt tgtaactatt caggtggaac tgaaatttca ggtgggattt tcgggaatgt
    14581 cctaattaag ccgatcgcac cgattagttt taacgcatct ttaccaggaa tggcagcggt
    14641 tgtacttgat gatcaaggta aaccaattcg agatgaagtc ggagaactat gtttagaaaa
    14701 accttgggta ggtatgacga aaagtttctg ggaagatgat gaacgttatg taaacacata
    14761 ttggtcacgc tttgaaaata aatgggtcca tggggactgg gttatttatg acggtgagca
    14821 atacatcatc acaggacgtt cagacgatac gctaaatatt gcagggaaac gtattggtcc
    14881 tgctgaatat gaatctattc ttgtgaaaca taatgatgta atagaagcag cggcagttgg
    14941 tgtaccggat gatgtaaaag gagaagtttg tcattgtttt gttgtattac gagatggtgt
    15001 gacattctca ggagaattaa agaaagaatt aatgagttta gtaaactctc atattggtaa
    15061 agctttatgt ccaaaagaca tccacgttgt agaagattta ccaaaaacac gaaattctaa
    15121 agtaatgcga cgtgtcataa aagctgctta cttaggaaaa gaattaggag atttatcgtc
    15181 acttgtaaat cctgaagtgg taccctttat tcaaggacta cagtctagca aactataaaa
    15241 ttacgaatga gctctatgta aatagagctc atttttaatg tttacaaaaa gaaaagagag
    15301 gaaaagtaaa tttgaagtta aaaaatctac tattagtgtt aagtatgtct gtttgttttt
    15361 agtttttatc aaaataggat actgtggctg tctattcaat ggagtgaatg aattttgtta
    15421 agaatgaaaa tttagtgaag aaaaaagtaa tgaataaaag gagaaatccc tgggggacag
    15481 ggattcaata agggagatat tattgtcgtt caatgtcgaa atttggcgta tccgacaaat
    15541 taatattatc acgaattttc aggagattgt gatagtggat gtgtcaaaaa tgtgtacggg
    15601 tttcatataa aagtgttatt taaataggaa aagggaaaag aattaagttc actcgttctt
    15661 aagatttttt cccttttaaa tttactgttt gttcgttgtt ctatatacat ctgaaattgg
    15721 taaatcttcg ccatgtaaag cttgagtact gtcctttttg tttgaattat gtgcctcctg
    15781 agaggtttct tgcagttgtt cttgggcctt actaggggta ttcagcgcat ctaatgacac
    15841 aggatcaagt tgttgactta ataaatcttt tttatccatg ttatgtagct cctttttgaa
    15901 cttagatata aaaacaaagt atttttaaat agttacgtgg gtattatgta tctttgaatg
    15961 gaattatata cacaaactat attgagaatt taactaatta taaaaattac ttgtgctgac
    16021 aagcttaaga aatataaaga tcattagttc ttaataaaag cgttatttta gtaggctgtt
    16081 acgaaatttc atttgaaagg aacatcccaa tgataaaaaa gagcactgta aatcagtgct
    16141 catcttatta gatattgctt agtccttaaa aataaaacca ttacggacaa ttcacaatgg
    16201 taatagtgac gctagccatt gttccaggag aatcaagaag tgaagcagta acggttactg
    16261 ttccaggccc attagcggct agaaatacag cggtaaagtt acctgaagca ttggtaatga
    16321 ccgcaagagg aaccatgaaa gcaagagaag ggttactgaa tgaaaaactg accactactc
    16381 ctggagtagg actaccgttt actaatactt gacccgaaaa aaataaagta ttatttcctt
    16441 gagtggatac acatgctgtg gtttcgttag aagtcaaggt aatagaggca ggcccagcag
    16501 gaagattaaa tccagttggt ccagttggtc cggtagagcc agttggtcca gttggtccag
    16561 ttggtccagt tggtccggta gaaccagttg atccggttga tccggtagaa ccagttgatc
    16621 cggttggtcc agttggtccg gtagaaccag ttgatccggt tgagccagta gctcctgtag
    16681 aaccggtggg accagtaggg aattgaaagg gttgaacagg tggaagtgta ggtccaatag
    16741 aacccggatt aagtgcagca aaatataaaa actcgtccat tatttatcac ctctaaaaat
    16801 cgtattacta atagtaaatg taatgataga gcaatgtgaa atggacaagc ggttgtattt
    16861 taataaatta aacaaaatag ttatttgcgc gacacgtttc cttataagtg tgtgaacacg
    16921 aaataggagg gttatcaatt tttgataaca acaactgatt gactgaaagt aggaatgaaa
    16981 gccgtcaggt tgagctgaaa ctacttatct aatactccta catgcaagga gtgatagtag
    17041 tcacaaattg tatgaagcta ggtgaagtcg gctgaacaaa acctaagtga gaaatcatat
    17101 ggtaatggat aggccgggat gctacaaact atctatggtg agaatgtcca aacggactga
    17161 cgaacttgcg aatgtacggg tctaaactat taatacatta gaaatgtgta tgtcgttaat
    17221 gacgacgtta tttaccgaaa agtaagagta gataatatga aattcggaac atccaacgat
    17281 gaggatgtaa agataacagg cttacagcaa gcacctaagg atatatgtat agctaagtca
    17341 atcggaacgt ggtaagcaag aaactgtcat caacgcctac tagcggacag atgcatataa
    17401 ggttctaacg aaccgaaatt gcttcattct tgtgaaggtg gggacacagt accaacgaaa
    17461 catgtaacga atgtggaggg atagtcccta gtcttgttct ttgaaaacta aattaactag
    17521 atgtaactca caggatcgag taagatgatg ggacttttcg taagaaaggg gaattaacac
    17581 atcggtgagt acaacattac gacatgcaaa aagtgtttga tgatttatat caacggagca
    17641 aaaacaacgc tactaaaggt ataaatttat ataaacatct catatcaaaa gagaatattc
    17701 tattggcata tagaaacata aaggctaaca ctggctctaa aactgaagga acagatggta
    17761 tcacaatcga ccattataaa atggaagatg tagatttttt cgttgataac ataagaaaga
    17821 atcttgtaga ctacaagcca aatacggtac gtagggtaga aatacctaaa ccaaatggaa
    17881 agaaacgtcc attaggaata cctacaatga gagatagatt gattcaacaa atgttcaagc
    17941 aggttctaga gccaatatgc gaagcaaaat tctacaagca ttcatatgga tttagaccca
    18001 ataggtcaac gcatcatgcg atggctaggt gtcaattctt gatgaaccgc gggggatata
    18061 gtcatgtagt tgacattgat atacaaggtt tttttgataa tgtaaaccat tccaaactac
    18121 taaaacaact atataacata ggtataactg atagaaaagt actgacaatc atttctaaaa
    18181 tgttaaaagc accaatcaaa ggaataggca ttcctacaaa aggaactccg caaggaggga
    18241 ttctaagccc attactaagt aatgttgtat tgaatgactt agattggtgg ataactagtc
    18301 agtgggataa tatcaaaaca aggaaaacat atacactacc aaacaaaaat tatcatctat
    18361 caaaaacaaa attaaagaga atgtatatag ttaggtatgc ggatgatttc aaaatattta
    18421 caaacaatca caaatctgca actaaaatat tttatgcagt ggaaggttac ctcaaaaatc
    18481 acttaaacct tgatgtatct aaggaaaaat caactataac taacctaaaa agaaaatctt
    18541 cggattttct agggttctct attaaatttg ttaaaaaacg caaaagatat gtggcaaata
    18601 cacatgtaag cgagaaaaag aaaaaggata ttcttgaaaa agcaaaaaca agaattaaag
    18661 caattcaaaa aagtccatct ggaaaaacaa tacaggacta taattcctat gtgcttggta
    18721 taaaaaacta ttacaaaata gcaacacatg tatctataga ctttactgaa atagcctttc
    18781 gtctctcgaa aaccttgttt aatcgtctaa aatcaatagg aaaatataag attcctacta
    18841 atacaaacgc attatacaaa agaactcaca ggaacaatta tagaaccttt gaaatagcag
    18901 gtaatcatgt atatccatta gcggacatac aaacacgatt ccctcaaagt ttcagtcaag
    18961 atatatgtaa ttacactaaa aaaggaagac aaaaactcat caaaagctta aaaggtaaca
    19021 ttgccaatga aatgcaaaaa atgttgctat cctccaccaa agggaaaagc atggagtata
    19081 tagataacag aatgtcgaaa tattccatgc aaaatggaaa atgtgctgtc acgggaatct
    19141 ttttgctagc tgatgaagca cactgtcatc acaaagtacc gaaaggtatg ggaggaactg
    19201 acgagttcaa taacctaatt attgtacatg aatttgtcca cagactgatt cacgctataa
    19261 atgaagagac gattagaacg tatatgagaa tacttcaatt gaacgataaa caattgaaga
    19321 aaataaataa gctccgtaaa gcttgtaatc tagttacttt agtatagaag aataagatgg
    19381 gacgccgtat gtcgggaaac tgacacgtac ggtgttaggt gggggaaaag gtggagatgg
    19441 tatcaaagcc ttacctatca cgcacgatag aaaaagaaat tagtatgttt attttagaaa
    19501 ttaaatataa aaaggcgatt atcgtcaaat cgccttttgg ggtaatgcag tgtaatttta
    19561 ttcagttatt tgaaatatag tttcattcgg tttggaaaat ccatacagtt tccttgcgaa
    19621 ttttaaaatt tcttcttcac tacctgttaa agccttaaca tcatttttaa gggaatgacc
    19681 atccttcttt aaagaagata atttttgttg ctccgtatta accgtgattt gtttttcttt
    19741 aatcatttct tgctggttat taagagaata ttgaaggaca aaaattatag gtaatataaa
    19801 agctaaagta gttataatac ggcgtcttgc ttttttatta ttactttgtt tggtgttagc
    19861 gttcacttgc tgtgagggta tcttaggatt tgattgttgt gatgatattt ctgggatgtt
    19921 tcccattaaa atgcctccat tactgattgt agaatttaaa ctgtttaaaa gtattataaa
    19981 tgttcaatgg gaattctaga agatagttta atataggtga gttttgtaaa gtttaaacaa
    20041 aatccttatt taaataaaag gaaccccgat tgtctgcggg gctcctaagg gtaatcgtca
    20101 agtaatgacg tactcgacta gttaacgata tcatgaattt tttggtaaat atactggtaa
    20161 atgcgtccaa attaatgaga gcattatttg aaacaaaaac gctattttaa tagggagggg
    20221 aataatgatg attccatggg acaagcgagt atacattgta tcaaggtgat cattttatta
    20281 cagaggggat aattttagag gttagtgaaa aggcgaataa atcattatat tggcgttggt
    20341 gcatgttagc tccaagatat gaaaaagtgt gcggtaatag tacaaagcga cttcggttga
    20401 ttcggataga tgatgatgaa gaatgatata aaaatttcat tttgtagaga aatgaggtga
    20461 ttaaggatgg gcatagaata tgccatgttt gtattaaaaa agagcagaat ttagcctata
    20521 tataaagatg ttggaattgt tctaaagggg ggaatatctg gaatataaat aattgagggg
    20581 agtgaactaa taatggaaac tagtactttt ttaggattgt tttggggatg gataacggtt
    20641 atcgtatcgg gaatactttt cgtacgtcca tcggtactac gtgaattgaa aaaattagtg
    20701 gttgaagaca gaggatttgg tattatgtat ggttttctat cgattttcct agggttaggt
    20761 agtgtaatcc tacataatgt atgggtattc aactggcagg ggttcctaac ggttattgca
    20821 tggcttgcat tattaaaggg aatctacata attgcatatc ctgaaccctc caagaaaaca
    20881 gactttgaat taagggtact atctacacgt atagcgctcg ctatcattgg cgccttggct
    20941 ttatggatgc ttatagtaat ctatataaaa taatcatttt ctaataagaa ctatattaaa
    21001 ataaatctct acgtgttcat tgacaaaaag ctgactatac ttagtcagct ttttgtatat
    21061 tacattctag tatttatcgg tcacaaaaga catgttctct cttttaagtc gatattgaaa
    21121 atgttaccaa ctttttcttt tacaatgaca acaaataaag aaacatttac aacgacactt
    21181 atttcgttta gaactccaat cattatcaca atgattcttt tctttagatt tccaccaatc
    21241 atcattacaa tgcttttcct tagaactcca atcatcatca caatgattct tttctttaga
    21301 tttccaccag tcatcacaac aatgcttttt cttagaactc cagcaatcat ttttccagga
    21361 cattctttta tacctccctt caataggatt catactattc tatgttttag taaaagaatg
    21421 gcttgtttat taacctatta ttttaccttt atatgataga gtgctttcta ctagatatag
    21481 aattcataca aactatgcta attttcaaga gatagttgag agaactactg gttatgatat
    21541 taatcaacaa acacttgttg aaggaaacgt taagatttta aataatatct tattttggag
    21601 tacgcttttc tgaatgtata tttcacaatg gtaaaggaaa aatacaccat atcactgcga
    21661 acaaagccta tgtatatgtg aagtaatagg aaaaggtggt ccctattcaa ggagccggct
    21721 tattaaaagt ataaataaga aggtttagta caagtgtttg tttttttgtt tctatgcttt
    21781 tgtctcgtac acttttaagc tattggacat actttactag tagaaaggat tagggggtga
    21841 ggttttgggt tctcgattta ataattgtag aaagaaatgt acgtgtaagc atgatgattg
    21901 ttgggacatt tttgaagagt gtaaaaagga aaagaatgag aaatgtgaca gttcttgtgt
    21961 acaaggaatt agagatgagc ttaaaaaatt aattaataaa acagtgcgaa ttaacactga
    22021 aggacgtact tatataggta ctgtttcttc ggtaacttgc gatgttgtta agctagctgc
    22081 tattcctggt tcagttgcag caattatatc tctttgtaaa attgaagcaa ttttaccacc
    22141 tgctacaact gttactgatg agtttgattt taacggtgtt gacgtagcaa ataaagatta
    22201 attatgcttt attgatgcta agccattctt atgaatggct ttttattttg tttaaaaggg
    22261 aatatatttt tcatatagaa ataaatttga aggtgtataa aaggttgtgt gaaaggagaa
    22321 tgagagtgat caagctgaaa caatttacaa gatctgattt caaacaatta ataaattgga
    22381 ttaattccga agaattttta atacaatggt cgggaaatgc attcacatat cctttaaatg
    22441 aacagcaatt agagaaatat acagaatgtg caaacacact ggcattcaaa ataatggatg
    22501 aagagactaa agcagttatt ggtcatattt ctcttggaca aatagataat ataaataagt
    22561 ctgctagaat tggaaaagtg ctagttggta atacgaaaat gagagggcgt tctataggga
    22621 aacatatgat gaaagccgta ctttgtattg cttttgatga attaaaacta catagagtaa
    22681 ctcttggtgt ttatgacttt aataagtcag ctatttcttg ttacgaaaaa ataggttttg
    22741 taaaagaagg tttattaaga gagtcaaaaa gagtaggaga aacgtattgg aatttatggg
    22801 aaatgagtat gttagaatat gaatggaaca ataaataata gtattttata attatattat
    22861 gttaacaaaa ggggtttggt gggaatcgtg aataaaaaaa caaaaataat ttcaattgca
    22921 gctgtttcag ggggcggtaa aactaccatt acagaaagtt tagctcatga gttgaaaaaa
    22981 tcaaaggctc tatattttga tagatataaa tttgataact gtccggttga tatttgcaaa
    23041 tggattgatg atggagctaa ttacgatgaa tgggtactta caccgctaat gaatgatatt
    23101 cagcgttcta tacaagatag tagtttagat tatattattg tagattatcc ttttgcatac
    23161 ttaaatagag aagtgggaaa attcattgat gtaactatat ttatcgatac acctttagat
    23221 attgcgatgg ctagaagaat tttgagagat tttaaagaag atacaatgag tgaaatacat
    23281 aataatttga aacattacat gacacatgcg agaaaagctt atttagaggc aattcatact
    23341 gttaagccga attcggatat tgtattggat ggatctttat ctataagtga aataattgat
    23401 caaataatag aggaacttaa tcgaagagaa gtgattgtga atggttaaat gtataaaacg
    23461 atatgtacaa gtcattatct gatttatata gacgagaatt agataacttt ttgcagttat
    23521 ggtctggcga cttcgaatca aaaatattga aagcttcatg gacagataaa acatataaat
    23581 acggtgaagt tttaatgcat gtaattgtac atgaaattca tcatattggt cagatatcta
    23641 tatgggcaag agaattaaat cttcagcccg tttcagcgaa tttagttgga agaggattgt
    23701 agatttagaa accgacttgc agtgtaaacg caagtcggtt tctatatata agaagatttc
    23761 ttaattaaaa tcctcggctt ttttttgacg tatatataaa aacattaaga ttgtaatgat
    23821 gaaaaagatc ataatcattt gtatgattaa atttttaaac tgaaacaata ttgtccaaga
    23881 tgtaacagca tctttaaaag cttggagtgc agagtacgag gaaggatcaa aaccgtactg
    23941 aagtaacttt tttgtttcaa taaaagtact gttttcatca ccggcgtcta atattactga
    24001 aataagtcta gtatctcctc gtgtggctgt actgacaaaa ctataattac cattagttga
    24061 aaaactagtt tgtaagccgt caacaccttg gagtttaatg tttttattaa gggaatatat
    24121 cattttattt gtattgaaaa cttttgaatc tttgaaggta aattggtaag aggttagttt
    24181 cgtaacattc aatacatctg gaaagtcttt tactaattgt gttgctagtt tagcgacgtc
    24241 tatcgatgtt gtagttgatt gtttattcgt atcgttatta attccagtag catttagaaa
    24301 cggggatggt tgtgataact ttagttgttt tgctttgtca ttcattaaaa gtgtaaagtt
    24361 atcttcgttt ccagcaatgt gttctgcaag ggcaagtgcg gaacgattat tccctgtcaa
    24421 aaacaatgca tgaagtaaat cacgaaccgt cgttttatct ttcgaagtta cttgtatagg
    24481 actcgtttct gctcggaaaa cttcgttact tatttttact aattcatcta actgtatttt
    24541 tccttcattc agttgttcca gtgcgatata ctctgtcatt aatttagata aagtagctga
    24601 ttgtatagga gtttcttcat tttttttata aacaatctca ccagaattag tatctattaa
    24661 aatagctgat ttagcttgaa taattggacc atttacataa agataaaaat ataaaacgat
    24721 aagtgcagta ataagaaaag ataataataa aactgttatt ttttttaaga attgcattag
    24781 cgatcctcct actattacat caataatatt attgtaaaaa ggaatgctta attaggaaga
    24841 aagaaaaggt aaagaatttc taaagaatta taaaggatta ttaaattttg gatattgatg
    24901 gaatataaaa ggttcaattt tttatatgat aaaaaattga acctataaat atgtggtatt
    24961 aagctttata agggagtaat tttacagtga aagttgtttt tttatcatcg ctatatactt
    25021 caattgttcc tttatgcaat tcaacaatac tttttgcaat tgctaatccg agcccagatc
    25081 caccagtgtt tgttgaacgt gatttttcaa cacgataaaa acgttcaaaa atatgaggta
    25141 aatcagtact agggataggt tgtccgtaat ttgttatatc aattgtaatc atattattgc
    25201 tttcgtaagc ggtaatatca atatgatctc catcattt
//
