LOCUS       NZ_CP059997            20999 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 10124220
            Orig. end                         :: 10145219
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20999
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="furan"
                     /region_number="48"
                     /rules="(mmyO or AvrD)"
                     /tool="antismash"
     cand_cluster    1..20999
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(mmyO or AvrD)"
                     /kind="single"
                     /product="furan"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20999
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:10999](+)"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10999
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(mmyO or AvrD)"
                     /neighbourhood="10000"
                     /product="furan"
                     /protocluster_number="1"
     misc_feature    complement(21..36)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.81"
                     /tool="antismash"
     misc_feature    complement(938..949)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 20.11"
                     /tool="antismash"
     misc_feature    1756..1769
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.08"
                     /tool="antismash"
     misc_feature    complement(1756..1769)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     misc_feature    1899..1914
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: medium, score: 26.61"
                     /tool="antismash"
     gene            complement(2239..2883)
                     /locus_tag="HUW46_RS47045"
                     /old_locus_tag="HUW46_09334"
     CDS             complement(2239..2883)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229280.1"
                     /locus_tag="HUW46_RS47045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09334"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_254125609.1"
                     /transl_table=11
                     /translation="MVEPRMPESAATVYNDLGRDYEDAFGHQPEVGATLEHLLTLLPAE
                     ANVLDLGSGTGWPVAATIADAGHRLTGYDVSDTMVRLARDRVPAASFERADMRLLDFEP
                     GRWDAVLTFFSMLQIPCQEQDTMLTRLVSWLAPGGYLVMATVPTETDHQAGEWMGHWVQ
                     TYSFPRELLRNRLKKADLHIVREKLVQYVPETDQAGPEPQIYFTARKPPVA"
     misc_feature    complement(2371..2373)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2964..3875)
                     /locus_tag="HUW46_RS47050"
                     /old_locus_tag="HUW46_09335"
     CDS             complement(2964..3875)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014684.4"
                     /locus_tag="HUW46_RS47050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09335"
                     /product="ABC transporter permease"
                     /protein_id="WP_215545088.1"
                     /transl_table=11
                     /translation="MSDFVVLLLGSTLASAAPLILAGLGEMFLERSGGGFNLGIEGILL
                     CGALAGVLGSYAGGPGLGLTAGAVAGLMWGAIFAISAAIGIDTVLIGIAITIGGTGIST
                     FFSQVVAPSGQRNITAPLLPAFPVPGLAELPVLGQPLGAVSAGVWLSVAVAGLSAWVLR
                     RTRYGLRLRAAAEASTAVVKGIDVGRYRASAAMIAGALTGSAGAVLAIGSIGTFTPLMS
                     GGRGFLVLAVVIIGGRKPAGVVAGAVLFACLDGLALMAQTRDLGLPSEAYHCFPYVAAL
                     AVLCGRARWHTVRPVTGAIRRT"
     misc_feature    complement(3075..3077)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3868..4851)
                     /locus_tag="HUW46_RS47055"
                     /old_locus_tag="HUW46_09336"
     CDS             complement(3868..4851)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014684.4"
                     /locus_tag="HUW46_RS47055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09336"
                     /product="ABC transporter permease"
                     /protein_id="WP_215545089.1"
                     /transl_table=11
                     /translation="MVSLIVAMTGGDLVDAVAGWFHGAAGTPYSALQTLAYAVPLALIA
                     LGASPALRAGVVVVGAEGQLVVGAIAATALMLSPVGRLPGILALPLGAGAGIAGGVLWA
                     MIPAVPQVRWRVSEILSALMANYIATHLLSFLLRTSLRDPDGFSAPRSADLPSSALIPF
                     LPVPGRLTTGVLIVVVAAGVGLWWRRTRSALVLDVFAEQRWLAARLGGSTTRVIIGTTA
                     LSGAAAGLTGWLQVAGVDGRLTPGVAGGIGFTGLVVAVLGRFRPIPIMIAALLMASLFT
                     GANGIQMTSAIPASIGTVTQGVLLLAVAAAVTVARRSAPNRGGMRE"
     misc_feature    complement(3937..3939)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4429..4431)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4926..6404)
                     /locus_tag="HUW46_RS47060"
                     /old_locus_tag="HUW46_09337"
     CDS             complement(4926..6404)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="HUW46_RS47060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09337"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_215545090.1"
                     /transl_table=11
                     /translation="MTTEQTLALRNVSRRFDTVQALNKVDLTVTSREIHAVLGENGAGK
                     STAIRILAGLDQPDSGMVEHDGVPVRFESRESALRHGIGLIPQTGSLSGELTLLENFAL
                     TAPARLLRRREARRSLEAALDAVGVNVDIAVPTWQLGRARQQLGEVVLAVAQGARTLLL
                     DEPTSVLDVSEIRGLHSHLRTLASAGLGVLIVTHRIREARAIADRATVLSQGAVSWHGM
                     ATTADDLTLARAMVGGTPRARRRSPRPAPDPTSQPALTLTAVTAATDDLAPIEDIDLTV
                     RRGEIVAVIGTAGSGQRALAEVAAGVIAPARGTRTVEGSVAYVPEDRGRALLLTRPVKW
                     SAILTQLRDPRFATRGVIDTAEVTRFARSMLTRLDVRPPDPDIPASALSGGNAQKLVIG
                     RELDLRPALAVLHAPTQGLDVAAASVVRERILAAASDGTAVLIVSADHDEASSVADRVL
                     VLADGRITGDYTASSYDHARHNLAVSRADDQPPC"
     gene            complement(6401..7381)
                     /locus_tag="HUW46_RS47065"
                     /old_locus_tag="HUW46_09338"
     CDS             complement(6401..7381)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014647.4"
                     /locus_tag="HUW46_RS47065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09338"
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_215545091.1"
                     /transl_table=11
                     /translation="MTLIISMMVAGCGSGASPSGNKGAIRVAIILGGVANDGGFNEAGA
                     TAARSLRERRLVDTVQIRESVSTAHDAEPIVRQYAADGYDLVIGWSSVFADSLYRISAE
                     FPDSHFLTTGDATDKQKSAANVENWNWDSEQFGYLLGWVAGHTHLSPIGIVDGQQIPPQ
                     ERQWHGFELGVHAVNPGATVRTPIYLGSWEDAQAAHRATIAQLDSGARLIATNAEGYSP
                     GVAAAAASRDTATLGMSSTTSDAATTVNIGRARLDMTPILPTIVERLKNGSFGKKTSVS
                     TIQNRSLILDTVHKVQAAPAVPDDLQSRAGDLARQLAEGKVRIGS"
     misc_feature    complement(7372..7392)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.63"
                     /tool="antismash"
     gene            complement(7542..8120)
                     /locus_tag="HUW46_RS47070"
                     /old_locus_tag="HUW46_09339"
     CDS             complement(7542..8120)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09339"
                     /product="hypothetical protein"
                     /protein_id="WP_215545092.1"
                     /transl_table=11
                     /translation="MDRAKREMWKKCAAALCSLELPDGFGIDELLVAVSRQRGGRPILA
                     RPADLTGSTPLGLVVQHRGHDTILYPRDTTVVHQRHCIAHEIGHLALGHLGDPGEPAQP
                     GSGELDVELVLGLIPDLHPSLRGKHRTRATYGDLAEREAEQFATMVHTLAMSLGGAVPR
                     QREEKPLPAGLRTLFDASPLASVDHPCGV"
     misc_feature    complement(7953..7955)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8347..8362)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.2"
                     /tool="antismash"
     gene            complement(8615..9322)
                     /locus_tag="HUW46_RS47075"
                     /old_locus_tag="HUW46_09340"
     CDS             complement(8615..9322)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09340"
                     /product="hypothetical protein"
                     /protein_id="WP_215545093.1"
                     /transl_table=11
                     /translation="MDDGDRLAPNWEISRKLWYLREQCCDSRGRVRSFEEIAEHVRAVT
                     GRNHDPVYLAKFFTGEARRKPEGPLLAAILDAFGKVPSDLWDRGDPAGTFGQRLQHQRY
                     LRGCASPQQKLPTQDEIAQHVERQTGRSCTGAYIGLLINDKARNGPAIDKIQALADYFE
                     ISPARFFDDPHSQELIASERVMQEQKAFIDALAELHQVTGGLGFRLSEPVDPADLPKLT
                     EEIRHEIEAAKKQ"
     misc_feature    complement(9113..9115)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10001..10999
                     /locus_tag="HUW46_RS47080"
                     /old_locus_tag="HUW46_09341"
     CDS             10001..10999
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) furan:
                     AvrD"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017469.4"
                     /locus_tag="HUW46_RS47080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09341"
                     /product="AvrD family protein"
                     /protein_id="WP_215545094.1"
                     /sec_met_domain="AvrD (E-value: 1.1e-90, bitscore: 303.5,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWSERTYPRIEDHLGPRDRRFFGTGYKRVRHQLADAIVDADARR
                     ITAGASLDYPEDWSSKSASVSLRPHVSTIDAVVLSVALAETYLSYAFGFDAASRRSLWL
                     RRMVIKAGTTAQENLRNVGVHADLVGTAERSGFAVSTFDGAVGNLRTRCEVAHPVVRDH
                     LLSAAVALPEDLLGDAERRYFGTGYQRRVHELSNVRVAPRDSVATADADVLDPDPCVQG
                     LAGQYQPAFSIIDGIIVLAQLSQSFLYQLDDIDRANSHTLWMRRLEATSHIPPSPLTDR
                     VPARTSMTRSAILNFDGSAWRTSEWDSHLHGIRFSYRLGHRLPISSLVAAA"
     gene            10996..11523
                     /locus_tag="HUW46_RS47085"
                     /old_locus_tag="HUW46_09342"
     CDS             10996..11523
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09342"
                     /product="hypothetical protein"
                     /protein_id="WP_215545095.1"
                     /transl_table=11
                     /translation="MSARLACEHGDLLIVAEGAARLSWTRTGPARWKPIGLWPSRHEQT
                     EIADRVDAGLPMLVVLAEMPTIVPMLTEELLDAPEDLLSLAEFTGYLAELRIPFLGWLP
                     PELRERGRRFFEATRRRPQAKPSVTRPPLLLDDPDHDAPHVRFARWLRPGHPPVEDLVP
                     VATKIFLREDQP"
     gene            11520..12293
                     /locus_tag="HUW46_RS47090"
                     /old_locus_tag="HUW46_09343"
     CDS             11520..12293
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024911.4"
                     /locus_tag="HUW46_RS47090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09343"
                     /product="AAA family ATPase"
                     /protein_id="WP_215545096.1"
                     /transl_table=11
                     /translation="MTQQPSLRLAVSGTYSTGKSTTTEALSIATGIPRTHAKTSREILM
                     DIVPGKQVQELSAMELIKLGLRRFEERVANESLPGSFISDGSVIHEWVYGEARMRVGIN
                     PGASWWLRRVKAVSGWRTKRFYQQYMDMYGELTKDRARRLYDAYVHLPVEFDMHADGHR
                     PVSEPFRAVSDRLLHNAVQEMGVPYYVVHGSIKERLTAIVDLFDLNLIVPLDDAIDQAQ
                     RRVHNAISILHADDRFHEAQRRKSFFRRLSYALRY"
     misc_feature    complement(12307..12321)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.13"
                     /tool="antismash"
     misc_feature    12444..12455
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.98"
                     /tool="antismash"
     gene            12734..13825
                     /locus_tag="HUW46_RS47095"
                     /old_locus_tag="HUW46_09344"
     CDS             12734..13825
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09344"
                     /product="hypothetical protein"
                     /protein_id="WP_215545097.1"
                     /transl_table=11
                     /translation="MSTTSTPVAALPRSSSSRVLVHRVGTPPAGTAADPRSSMQWHLDH
                     RHGAQLTAVPFDVDDRWIATWLDGLADVPGLVQIRSGDYRGYDDMPYYAIADGRHLVPE
                     DLALGRPRLTEQAFAAYPHLTGSDIPRRLQVSIPNALDLSYFASGSVDAATHWMPTMQS
                     MVSGEVSTLSEQWGDRILLQLESPAILLAYHSTPRQDWSLLTSELVRQVSGVLGAAPYA
                     DWVLHLCYGDLEHTPLFEPTDLTAATMFLNALSDQLADRGQRMPTVHLPLTHGDAAPPV
                     DPLFYAHLRRLRRGIPIIAGLVAEEHPHQTSVASELLVGALGVPVEAISAACGLGRRSE
                     TAGKANTLLAATVALGWNERAAS"
     gene            14164..15237
                     /locus_tag="HUW46_RS47100"
                     /old_locus_tag="HUW46_09345"
     CDS             14164..15237
                     /NRPS_PKS="Domain: Abhydrolase_1 (75-200). E-value:
                     1.3e-11. Score: 36.5. Matches aSDomain:
                     nrpspksdomains_HUW46_RS47100_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="HUW46_RS47100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09345"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_215545098.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.6e-15, bitscore:
                     55.9, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.7e-07, bitscore: 29.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIIYHTIARIAVTTALAATAALGSGTATATTVAPSPDPARSCRD
                     ITFPTRTGPLETTIHGVLCAPTTHPIKGTQVLLHGATYNSQYWDPPVANGKYSYAKQMN
                     NAGYRTLALDRLGAGTSSRPPSVLLSVDNQADAVHQVITHLKAGHLIDAPARRIALVGH
                     SMGSAVATVEQTTFHDVDAVVMTGATAHIDPAFLLTTLTNYMMPATLDPKFGPFSGQLV
                     DPLYLTTRPGVRSAAFHAATDVDPEVVQVDEATKDLVATTEILGAITKGWAPETTRRIT
                     VPTMVQLGGADNFFCPPGRGDCSSAETLARAVEHDFAPAAQLHTSILPAAGHDLQLARN
                     GATAAAEVSSWMDRALP"
     aSDomain        14389..14763
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS47100_Abhydrolase_1.1"
                     /evalue="1.30E-11"
                     /label="HUW46_RS47100_Abhydrolase_1.1"
                     /locus_tag="HUW46_RS47100"
                     /protein_end="200"
                     /protein_start="75"
                     /score="36.5"
                     /tool="antismash"
                     /translation="VLLHGATYNSQYWDPPVANGKYSYAKQMNNAGYRTLALDRLGAGT
                     SSRPPSVLLSVDNQADAVHQVITHLKAGHLIDAPARRIALVGHSMGSAVATVEQTTFHD
                     VDAVVMTGATAHIDPAFLLTT"
     CDS_motif       14623..14673
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS47100_0001"
                     /evalue="2.00E-03"
                     /label="NRPS-te1"
                     /locus_tag="HUW46_RS47100"
                     /protein_end="170"
                     /protein_start="153"
                     /score="10.8"
                     /tool="antismash"
                     /translation="PARRIALVGHSMGSAVA"
     gene            complement(15455..16444)
                     /locus_tag="HUW46_RS47105"
                     /old_locus_tag="HUW46_09346"
     CDS             complement(15455..16444)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015338.4"
                     /locus_tag="HUW46_RS47105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_09346"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_215545099.1"
                     /transl_table=11
                     /translation="MTGPGFVRVVTANLHNLFLDGGEAELDTPRRRAQVALLRSLKPHV
                     LAVQEIVAADADPRTKTELAGRRLRLLGEALGMQCATASGVPTIAVGNQEYHTALLWSG
                     GISPVEGGWFAISGTNFFHSLALLSLDVGSKTPVVHGSAHLSWTGRERRSDEGERLLAA
                     MTRPAGHPPTLIAGDHNSVSAARISPPREPGSPWYGPYFDPDLDQARWRPGLDSYCSVS
                     LDPTTGTKSWSADRRPTEHLALAGMLDAAVVCGADPTPTVGHWPGSEHPLARFDQVWTT
                     PDLGPALSNYETVAEPRVVDDDVLDPKRLADHLAVVATYQPRRIRQRN"
     gene            complement(16441..16962)
                     /locus_tag="HUW46_RS47110"
     CDS             complement(16441..16962)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.4"
                     /locus_tag="HUW46_RS47110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phosphotransferase"
                     /protein_id="WP_215545100.1"
                     /sec_met_domain="APH (E-value: 2.3e-06, bitscore: 26.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIPSCDVAEGGPDRPLPSTVYRPWPGSDDTSTSLDGALRSGHRG
                     LHFANLGIDRRGEVVLLDLKTAATGHPLLDFGNLLDLGQLDDPSLRVVFVEGYDQETDP
                     GPAVARRGEAQRRPPGLRGSPRLRPPPVDARLRPAWVPPPRRTRTRHGDGPPVTVLTGV
                     LALPAAEPGP"
     misc_feature    17093..17108
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 22.3"
                     /tool="antismash"
     gene            17437..17820
                     /locus_tag="HUW46_RS47115"
                     /old_locus_tag="HUW46_09347"
     CDS             17437..17820
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09347"
                     /product="hypothetical protein"
                     /protein_id="WP_215545101.1"
                     /transl_table=11
                     /translation="MMNLLMMMLREFTWFGLVLAVVTVPLAVVAFSLPRMQLRTERRIS
                     TNRIAQYQALRQFLGTTTLSPVARPALPTPRSPRTWWRIWRTVWSRNRSGLDIPSDTDL
                     DTLSTRLRTAATTAWRFSGSWRS"
     gene            17790..18080
                     /locus_tag="HUW46_RS47120"
                     /old_locus_tag="HUW46_09348"
     CDS             17790..18080
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09348"
                     /product="hypothetical protein"
                     /protein_id="WP_215545102.1"
                     /transl_table=11
                     /translation="MALFRQLAILMGAILLTAETDHAPGPGNAAAPRTGASLVALVRQD
                     LRWEVVDGGARTPSPGSSPGSGGTPVVTGTIGQTLGRFFGAVTRGCARAAQ"
     gene            complement(18209..19177)
                     /locus_tag="HUW46_RS47125"
     CDS             complement(18209..19177)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215545103.1"
                     /transl_table=11
                     /translation="MTESGSRHDQQRVAGWLALTLQRRCGPLDGPRTAYRVTDHGAIEL
                     SWRGGPTAAEVADHLLRAADPDMPVTCDAQLSDSVVAAGVRVLLTALDPRPRSRSPRDP
                     IGALPASAAPRPIMDDGHAADIVTWELPPEPGGTGMAIVTRVPTSYTDALDWTAHATFV
                     AATGYQPPPGAHPQRHIRWARALANADVHLRFATPKLAIADADAWLSMAVGHSRGITPL
                     CAAVAWHDRCLMRLQPGLRVDAVLATSPHMTGVASRVPALLLSALHRTLLPRDTRTATT
                     LAASLPTDLHISCFRHGLDSERYRIQLAATIIPASQNRQTG"
     gene            complement(19251..19490)
                     /locus_tag="HUW46_RS47130"
                     /old_locus_tag="HUW46_09350"
     CDS             complement(19251..19490)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09350"
                     /product="hypothetical protein"
                     /protein_id="WP_215545104.1"
                     /transl_table=11
                     /translation="MLSNDSTEIAATLVAWIYTGTLRDSLDELQALTRVVHEVLAAVGG
                     ASRLRASILLHAPGSGHGEALLCRRAVAIVAASA"
     gene            complement(19570..19803)
                     /locus_tag="HUW46_RS47135"
                     /old_locus_tag="HUW46_09351"
     CDS             complement(19570..19803)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS47135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_09351"
                     /product="hypothetical protein"
                     /protein_id="WP_215545105.1"
                     /transl_table=11
                     /translation="MGRIDTRIDVVFALGSEQMWLLTWQMTHQIVPPLGDGGPPAAAIV
                     TAAGTGDTATLTTLVIDLHAAENSPLTRNARR"
     misc_feature    19757..19772
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.39"
                     /tool="antismash"
     misc_feature    20044..20055
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.06"
                     /tool="antismash"
ORIGIN
        1 caagctcacg ctccgcgagc ttgccccgat ggtcaattac tcctacagca tgctgaaccg
       61 ggtcgagagc gggaagttcc cgccaacgat ggagatggcc tcgctgctgg acaagacgct
      121 cgggaacggt gacggggcgc ttctggaact cgccaaggct gctcgtagcg aaccctatgc
      181 ggggcttcca ccgtcgccgg ctcatttcgt cggccgcgat cgagtgctca ccgctcttaa
      241 ctccgcgctg atcgatgagg cgacggatga ccggtccaac gtggtgttcg tgttcgggcc
      301 gcccggggtc gggaagaccg cactggttcg gtggtgggcc aacgactatc gggacaggta
      361 cgccctcgcc ctgtacgccg acctgcgcgg gttcgggcca cgcgacccag cgccgcccag
      421 cgaggttctc gaagctctgc tgcggggcct cggtgtcagc gacgaccgtc tgccgaacag
      481 caacgacctg cggctggcac tgttgcgggg gcacctgcag cgacgagcca gcatcggtca
      541 tcgggtgctc atcgtgctcg acaacgcact cgattcgcag caggtcaagg acatcctgcc
      601 gggttctccc aacgtgtcga tcttggtgac gagcaggcgt cggctgtccg gactagtgat
      661 ctccgccggc gcgcagggaa taccgctggc ccctatgaac aacgatgatg ccgcggagct
      721 cgtgcgcaac tatgtcggcg ccgaccgcgc cgacgcggag ccggacgcgg tgcgatggtt
      781 gacgagcctg tgcgcggcgt tgccgctcgc gctcagtatc gcggccgagc gggtggctgc
      841 gaacgacacg gtcagcatcc aggaacacgc cactggtctg gcgaactgcg cgctcgagct
      901 gcaggtcgag gatgacgagt cgaccggagt gcgggccgcg ttcagttact cgtatgactt
      961 gttgagcccg actcaggcgc ggcttttccg actgtgtggc ctgcatcccg gccctcgctt
     1021 cagtgtcgat tccgccgccg cgctcgccgg attgacagtg tcggagacct cgcgggtctt
     1081 ggagcaactg gttcagttct cccttctcga gcaggtcggt ctccatctgt tccggctgca
     1141 cgatctgctg cgggactacg cggccgcgga ggccgccaga tccgagtggg ccagcgagaa
     1201 cgaggttgcc gcgcgtcgcg tcgtgtcctg gtacctgcat ggagccaacg cggccgcatg
     1261 gatgatcact cctgagcgaa cggaacacca tctccggttg gattctccac ccgacgacgt
     1321 cagtcccccg cggttcacca gcttcgccaa cgcacggcag tggtgtgtcg acgaactgcc
     1381 gactatcgca ggcgtcgcgg agctggcact gcagcgtgga tggctgtttg aggcatggcg
     1441 catccccgtg gaattcttcg acttctttac ccaacatcgg ccggtcaagg cttggataga
     1501 cagtcttacc gttgcgctga gagcggcgga agcatctggt gtcgccttgc gcatcgcgca
     1561 ggcggccgag cagctttccg agggccacct tcgacatggg gagtcagagg acttggatcg
     1621 tgcgtggacc ctcagctcac gcgttcttga ggtgagccaa ggatcggaac cgaaccgctt
     1681 tatgacgttc gcgtacgtgg agttgggtga cgtacggttc aagcgtggtc acttcgagga
     1741 ggccgcgcaa ttgtacgaac aagcgttagc gatcgcacag aaggtcggtg cgcatgtcgg
     1801 tgagacgtat gcgcgtaccc acctcggcaa tgcatatctg aaactcgggg acgttgacct
     1861 agcggaagag cacggcctgc aagcgttcac catgtttgac gccgatggcg atcagcatgg
     1921 aatagggtat gcggcggtgc cattggcgcg cacctgtcgt gcggctggag accttgagcg
     1981 agcgctgcac tattgtgagg aaggctatcg cgccttccag cgttgcgcgg atcgtcaggg
     2041 gcaggctgag gcactcggcg agaaagcatt ggtgctgctc accatgggcg aatcacgcca
     2101 agctaccgcg tgctttcaag acgccctgaa ccagctgcga caactcgatc ttcgagcgac
     2161 cgagagtctc caccgtgatt ggcaagagtt agtgggaccg tcgacggctg tttagagcgt
     2221 tcgggccata tgagccgcct acgcgacagg gggtttacgt gcggtgaaat agatttgcgg
     2281 ttccgggcca gcctgatccg tttcggggac atactggacg agcttctccc gcacgatgtg
     2341 cagatcggct ttcttcagcc ggtttcgcaa taattctcgc gggaagctgt atgtttgaac
     2401 ccaatgcccc atccattccc ccgcctgatg gtcggtctcc gtcggcaccg ttgccatcac
     2461 gaggtagccc ccaggggcga gccaggacac caggcgagtc agcatggtgt cctgttcttg
     2521 acagggaatc tggagcatcg agaagaacgt cagtaccgcg tcccaccttc cgggttcgaa
     2581 gtcgagtagc cgcatgtccg cgcgttcgaa ggatgccgcg ggaacccggt cacgagccag
     2641 ccggaccatc gtgtcggaca cgtcatagcc ggtcagccgg tggccggcgt ccgcgatcgt
     2701 ggcagcgaca ggccaccctg ttcctgagcc gaggtcgagg acgttcgcct ccgcaggaag
     2761 aagggtgagg aggtgctcga gggtggcgcc tacctcgggc tggtgtccga aggcatcttc
     2821 gtaatcacgg ccgaggtcgt tgtagaccgt ggccgcggac tcgggcattc tcggctcaac
     2881 catgggtgcg cctctcctcg gtggggtggg ggaacgggtc gcgacggacg atgtgtgcgg
     2941 acagggtaac gccgtgcctg tgctcatgtt cggcgaatcg ccccggtgac aggccggacg
     3001 gtgtgccacc gcgcgcgacc gcagagcacc gctagcgccg cgacgtaggg aaaacagtgg
     3061 taggcctccg acggtaatcc gaggtcgcga gtttgagcca tgagggccaa gccgtcgagg
     3121 caggcgaaca agaccgcacc agcgacaacg cccgcgggtt tgcgaccacc gatgatcacg
     3181 accgcgagca cgaggaaacc tcgacctcca ctcatcaaag gtgtgaaggt gccgatgctg
     3241 ccgatcgcca gtaccgcgcc agcggaaccg gtcaaggcgc cggcgatcat cgccgccgag
     3301 gctcggtagc gcccgacgtc gatccctttc actaccgcgg tggacgcctc ggccgcggcg
     3361 cgcagccgga gtccgtagcg ggttcttcgc agtacccacg ccgacaaccc ggccaccgcg
     3421 accgacagcc atacacccgc gctcacagca ccaaggggct gccccagcac gggaagctcg
     3481 gccagtcccg gcacgggaaa cgccgggagc aggggcgcgg tgatgttccg ctgccccgac
     3541 ggggccacga cctggctgaa gaaggtcgag ataccggtgc cgccgatggt gatcgcgatc
     3601 ccgatcagga cggtatcgat cccgatggcg gcgctgatcg cgaagatcgc accccacatc
     3661 agaccagcca cggcgcccgc cgtcagtccc aaccccggcc cgcccgcgta cgagcccagg
     3721 acaccggcca gagcgccgca gagcaggatc ccctcgatgc caaggttgaa cccgcccccc
     3781 gagcgttcca gaaacatctc gcccagaccc gccaggatca acggggccgc ggacgcgagc
     3841 gtgctgccca gcaggaggac gacgaagtca ctcacgcata cctccgcggt tgggcgcgga
     3901 gcgccgggcg accgtgacgg ccgcggccac ggcgagtaag agcacgccct gtgtgacggt
     3961 gccgatcgac gcggggatcg cgcttgtcat ctggatgccg ttcgcgccgg tgaacaggct
     4021 cgccatcagc aacgccgcga tcatgatggg aatcggcctg aagcggccga ggacggcgac
     4081 gacgaggccc gtgaatccga tcccgcccgc taccccgggt gtcaggcgcc catcgacacc
     4141 ggccacctgt agccacccgg tcagcccggc ggcggcaccc gacaacgcgg tggtgccgat
     4201 gatgacgcga gtggtactgc cgccaagacg ggccgcgagc caccgctgtt cggcgaagac
     4261 gtccagaacc agggcggatc gggttcggcg ccaccagagg cccaccccgg cggcgacaac
     4321 gacgatcagg acgccggtgg tcagccgacc gggtaccggc aggaagggaa tcagcgcgct
     4381 cgagggcagg tcggcactcc gtggcgcgga gaagccgtcc gggtcccgta aggacgttcg
     4441 caacaggaac gacaagagat gcgtcgcgat gtagttcgcc atcaacgcgc tgagtatttc
     4501 gctgacgcgc cagcgaacct gcggaaccgc gggaatcatc gcccacaaca cgccacccgc
     4561 gatacccgcg cccgctccca agggcagcgc gaggatgccg ggcagacgcc ccaccggaga
     4621 gagcatcagt gccgtcgcgg cgatcgctcc gaccaccagc tggccttcag cgccgacgac
     4681 gaccacaccg gcccgcagtg ccggcgaggc cccgagcgcg atcagtgcca acggaaccgc
     4741 gtacgcgagg gtctggagcg cggagtacgg ggttcccgcc gccccgtgga accaccccgc
     4801 cacggcatcg accaggtcac cgccggtcat cgccacgatc aggctcacca cgccgaatcc
     4861 tgtcgcgacg cacaggccgc caatgagatg ccgcctggtt acgccgtggc gccggacgta
     4921 ccgaatcaac atggcggctg atcgtcggcc ctggatacgg ccaggttgtg gcgtgcgtgg
     4981 tcgtaggaag acgcggtgta gtcgccggtg atccgaccgt cggcgagcac caggacgcga
     5041 tccgcgacac tgctggcctc gtcgtgatcc gcggacacga tcaacaccgc cgtaccgtcc
     5101 gacgccgccg cgaggatccg ctcccgcacc acactcgccg ccgcgacgtc gagcccctgg
     5161 gtgggggcat gaagcacggc aagggccggt ctgaggtcga gttctcgtcc gatcacgagt
     5221 ttctgcgcgt tgccgccgga caaagctgac gctggtatgt cgggatccgg cggtcgcacg
     5281 tccagtcgcg tcagcatcga ccgcgcgaac cgggtcacct cggcggtgtc gatgaccccg
     5341 cgtgtggcga atctggggtc gcgtagctgg gtgaggatcg ccgaccactt caccggacgc
     5401 gtgagcagga gcgcccgccc gcggtcttcc gggacgtagg caacactccc ctcgacggtg
     5461 cgtgtcccgc gtgctggagc gatgacaccc gcggcaacct cggccaaggc gcgctgcccg
     5521 ctgcccgcgg tgccgatcac ggcgacgatc tcgccccgac ggaccgtgag gtcgatatcc
     5581 tcgatcggcg ccaggtcatc ggtcgcggcc gtgaccgcgg tcagcgtcaa cgccggctgg
     5641 ctggtcgggt ccggtgccgg ccggggagaa cgacgtctgg cccgaggggt gccgccgacc
     5701 atcgcgcgtg ccagcgtcag atcgtcagcg gtggtggcca tgccgtgcca ggacaccgca
     5761 ccctggctca ggacagtggc ccggtcggcg atcgcccggg cctcgcgaat ccggtgggtg
     5821 acgatcagga cgccgaggcc cgccgacgcc agcgtgcgca ggtgggagtg caggcctcgg
     5881 atctcactga cgtccagcac cgacgtgggc tcgtccagca acagcgttcg tgcgccctgc
     5941 gccaccgcga gaacgacctc accgagctgt tgccgcgcgc gaccgagctg ccaggtgggc
     6001 acagcgatat cgacgttcac gccgacagcg tcgagggccg cctccaggga gcgccgcgcc
     6061 tcgcgtcgtc gcagcagacg tgccggcgcg gtcagagcga aattctcgag cagcgtgagc
     6121 tcgccagaaa ggctcccggt ctgcggtatg agaccgatgc cgtgccgaag cgcgctctcg
     6181 cgtgactcga accggacggg caccccgtcg tgttcaacca tcccgctgtc cggttggtcc
     6241 agtccagcca gaatccggat ggcagtcgat tttcccgcac cgttttcgcc cagcacagcg
     6301 tgaatctcgc gggaggtgac tgtcagatcc accttgttca gagcctggac cgtatcgaat
     6361 ctacgggaca cgttccgcag ggccaacgtc tgttctgtcg tcacgacccg attctgacct
     6421 taccttcggc gagttgccgc gcgagatcac cggcacggct ctgcaggtcg tcgggaaccg
     6481 cgggcgccgc ctggactttg tggacggtgt ccaggatcag cgaccgattt tggatggtcg
     6541 acactgaggt ctttttgccg aagctgccgt tcttgagtcg ctccacgatc gtcggcagga
     6601 tcggcgtcat gtcgagacgt gctcgtccga tgttgaccgt cgtcgccgcg tcgctcgtcg
     6661 tggagctcat tccgagagtg gccgtgtcgc gggaggcggc cgcggcggcg acgcccgggg
     6721 aatacccttc ggcgttggtc gcgatcaggc gcgctcccga atcgagctgg gcgatcgtgg
     6781 cccgatgcgc cgcttgcgcg tcctcccagc tgccgagata gatcggtgtt cgcaccgtcg
     6841 cgcccggatt gaccgcgtgg acgccgagtt cgaacccgtg ccattgacgt tcctgcggcg
     6901 gtatctgctg tccatcgacg atcccgatag gcgacaggtg ggtgtggccg gctacccagc
     6961 ccagcagata gccgaattgt tcggaatccc agttccagtt ctcgacgttc gccgcggatt
     7021 tctgtttgtc ggtggcgtcg ccggtggtca ggaaatggct atctgggaac tcggcactga
     7081 tccgatacag cgagtcggcg aagacgctgg accagccgat caccagatcg tagccgtctg
     7141 ccgcgtactg ccggacgatc ggttcggcgt cgtgggcggt tgacaccgat tcacgaatct
     7201 gcaccgtgtc gaccagtcga cgctcccgca gggaacgagc agcggtcgcc ccggcctcat
     7261 tgaagcctcc gtcgttggcg acgccaccca ggatgatcgc cacccggata gctcccttgt
     7321 tccccgacgg gctcgccccc gaaccgcatc cggcgaccat catgctgatg atcagcgtca
     7381 cgccgaccat agccttgact gccactgcac gcacagttcc cgctcccctc atcgacgtgg
     7441 cacggcatac tctgccagcc aacgccatgt tgcatccaaa agttcaacaa gacgccggac
     7501 tctcccggtc atgcacacgt accgatcgga gcgcccgtcg gctatacgcc gcacgggtga
     7561 tcaacgctgg ccaacggcga tgcgtcgaac aacgttcgca acccagccgg gagcggcttt
     7621 tcttcacgct gcctcgggac ggcgccgccg agggacatcg cgagcgtgtg caccatcgtg
     7681 gcgaactgct cggcttcccg ttccgcgagg tcaccgtagg tggcccgcgt acggtgtttg
     7741 ccgcgcagag acggatgtag gtccgggatc agaccgagta ccagttccac gtccaattcg
     7801 ccactgcccg gctgggcggg ttcaccaggg tctcccagat gtcccaacgc caggtgcccg
     7861 atctcgtggg cgatgcagtg tcgttggtgc acaacggtcg tatcgcgcgg atagaggatc
     7921 gtgtcgtggc cgcgatgctg cacaacgaga cctaacggtg tcgatcccgt caggtcggct
     7981 ggcctggcca ggatcgggcg gccgccgcgc tgacgactca ccgcgacgag gagctcatcg
     8041 atcccgaagc catccggtag ttcgagtgaa cagagagcgg cggcgcactt cttccacatc
     8101 tcccgtttcg cacgatccac gacagcaacc tccccattgc cattgggaac aagggccctc
     8161 tccctccccg agtcactctg atggcctgtt gacgaaagcc ccggcatctg cggtcactcg
     8221 atccgctccc gtgatgtcgc gcgacactag cccgaacagt cgaagccgcg caatgaactg
     8281 ctggccgttg tgactccact cccgtccgcc tcggggagcc gatgcgctcg cagatcacca
     8341 cgaaatagtc gtctggacca gttgccgggt cagcttgcgc tccaggcagc gctacctgaa
     8401 tgatcacccg aatggtgcaa tggcgcggtc ggatgagacg acgggaatgt gtcgtcatat
     8461 ccccagacgt gtcacgtggg tgactccagc ctgcgttcag agcgtcgcca gaccaggcgc
     8521 acagcgggca gcctgctcga cgatccgttc gacaccgtca gagcgacggt gtccctgaca
     8581 cgatctcgag gccccggagc acgcgtggag cacgctattg cttcttcgcc gcctcgatct
     8641 cgtgtctgat ctcttcagtc agcttcggca gatcagctgg atcgaccggc tcactcagcc
     8701 tgaaccccaa ccctccagtg acctgatgca actcagcgag agcatcgata aacgccttct
     8761 gctcttgcat gactcgctcg ctggcgatca actcctgaga gtgcgggtcg tcaaagaatc
     8821 gcgccggact tatctcgaaa tagtcagcca gagcctgaat tttgtcgatc gccggtccgt
     8881 tgcgcgcctt gtcgttgatc agaagaccga tgtaggcacc cgtgcaactc cgacccgtct
     8941 gccgttcgac gtgctgggcg atctcatctt gcgtcggcaa cttctgctgg ggcgacgcac
     9001 acccccgcaa gtatcgctga tgctgcagcc gttggccgaa cgttcccgct gggtcccctc
     9061 ggtcccacag atcggacggt actttgccga acgcgtcgag gatcgcggcc aataaggggc
     9121 cctcgggttt gcgcctggcc tctccggtaa agaatttcgc gaggtagaca ggatcgtggt
     9181 tacgcccggt gaccgccctg acgtgctcgg cgatctcttc gaacgatcga acacggcctc
     9241 gcgagtcgca gcactgctcg cgcaaatacc agagcttacg ggagatttcc cagttggggg
     9301 cgagacggtc accatcgtcc attcaggtca actcccatcg tcgcgctcag cgcagtgacg
     9361 ccctacgccc gcgcccccag tgcgagatca ggcccatccg gaccacgatc cccgcgccac
     9421 gggcggatcc taaccgaacc gaaggatcca cataagtcag tgccacccgg acaagggagc
     9481 tcgccaaccg gcgtgggagg cggggcgccc gcgcccccgc ggtgtcgtcg ccgcgtgcac
     9541 acttgcgatg taacaccctc gatctgtttg cattccacac ctggatccat atgctcgatt
     9601 tgtcgaacgc aacgggatca gtgccatcgc ggcgatgttc ctgtcaacca gcgtggcacg
     9661 gggattccac gctgttcagg cacgagtcgt cgcgggtcga acacacctgt cctcccacat
     9721 ccatacctgg ccttcgcccg ccgccgacac cagagagcac cgcccgtccg gggctgggat
     9781 gccgccgcat caccacccta ttcatatgtc gagacagttc gaggagacga acccatgcgc
     9841 ccaccgacat cccgaccagg tgagaacgcc gctcaccaca tcggctcgcg atccctcgcg
     9901 cgtgccctca tgcgttcggg cgcggacgct ggatgcccac cggcggatcc ggctcggggc
     9961 acagggcgca ccagcgggcc ccatggggag gacgactgac atgtcgtggt ccgagcgaac
    10021 ctatccccgc atcgaggacc atctcggtcc ccgcgatcgc cgcttcttcg gaaccggcta
    10081 caagcgcgtc cgccaccagc tggccgatgc catcgttgat gcggatgcgc ggcgaatcac
    10141 ggcaggcgcg agtctcgatt accccgaaga ctggtcgtcc aagagtgcga gtgtctcact
    10201 acgaccgcat gtcagtacga tcgatgccgt cgtcctgagt gtggcgctcg cggaaacgta
    10261 tctgtcctat gcgttcggct tcgacgccgc gagccggcgc tcgctgtggc tgcggcgcat
    10321 ggtgatcaag gcgggaacca cagcgcagga aaacctccgc aacgttggtg tccatgcaga
    10381 cctggtgggt accgcggaac gatccgggtt cgcggtgtcc actttcgacg gggcggtcgg
    10441 aaacctgcga actcgttgcg aggtcgcgca tccagtcgtg cgcgaccacc ttctcagcgc
    10501 cgcggtcgcg ctcccggagg acttgctcgg tgacgcagaa cgccgctatt tcgggacagg
    10561 ctaccagcgg cgtgttcacg agctctcgaa tgttcgggtc gctccacggg acagcgtcgc
    10621 cacggctgac gccgacgtcc tcgatccgga tccgtgcgtt caggggctcg cggggcagta
    10681 tcagcccgcg ttctccatca tcgacggcat catcgtgctc gcacaactct cgcaatcctt
    10741 tctctatcag ctcgacgaca tcgatcgcgc caacagccac acgttgtgga tgcgtcggct
    10801 ggaagcgacg tcgcacattc ccccttcgcc cttgaccgac cgagtgccgg cacggacatc
    10861 gatgacccgc tcggcgatcc tgaacttcga cgggagcgcc tggcggacgt cggagtggga
    10921 ctcccacctt cacggcatca gattcagcta ccgccttgga catcgcctgc ccatttcgtc
    10981 actggtcgcg gccgcatgag cgcccgactc gcgtgcgagc acggcgacct gctgatcgtc
    11041 gcggagggcg cggcgaggct cagctggaca cgcacaggcc ccgctcgctg gaagcccatc
    11101 gggctatggc cgagccgaca tgaacaaacc gagatcgcgg accgggtcga cgccgggctt
    11161 ccgatgctgg tcgtcctcgc cgagatgccc acgatcgtgc cgatgctgac cgaggaactc
    11221 ctcgacgccc cggaggactt gctcagtctc gccgagttca ccggctacct cgctgaactt
    11281 cgaatcccgt ttctgggctg gcttccgccg gaattgcggg agcgtggccg acgattcttc
    11341 gaggccactc gtcgtcgtcc ccaggccaaa ccgtcggtaa cgcgaccgcc tctcctcctc
    11401 gacgatccag accacgacgc tccccatgtc cgattcgcgc gatggttgcg ccctggtcat
    11461 cctcccgtcg aggatctcgt tcccgtggcc acgaagatct ttctgcgaga ggaccaacca
    11521 tgacccagca accgtcgttg cggttggccg tctcgggaac ctactcgaca ggaaaatcga
    11581 cgacgacaga agcactctcg atcgccaccg ggatcccccg cacgcacgcc aagacatccc
    11641 gcgagatcct gatggacatc gtgcccggca agcaggttca agaactctcc gccatggaac
    11701 tgatcaagct cgggctacgc cgattcgaag agcgcgtcgc gaacgagtcc ttgccgggat
    11761 cgttcatttc cgacggatca gtcattcacg agtgggtgta cggtgaggcg cggatgcgag
    11821 tgggcatcaa tccgggcgcc tcatggtggt tgcgccgcgt caaggcggtg tcaggatggc
    11881 gaacgaaacg gttctaccag cagtacatgg atatgtatgg cgagttgacg aaggaccgag
    11941 cacgacggct ctacgacgcc tacgtgcatc tccccgtcga gttcgacatg cacgccgatg
    12001 gacaccgccc cgtctcggaa ccattccgcg ctgtgtccga tcgcttgctc cacaacgccg
    12061 tccaagagat gggcgtgccc tactacgtcg tgcacgggtc gatcaaggaa cgcctcaccg
    12121 ccatcgtcga cctattcgac cttaacctga ttgttcccct ggacgacgcc atcgaccaag
    12181 cccagcgacg agtccacaac gccatctcga ttctgcacgc ggacgaccgg ttccacgaag
    12241 cgcaaagacg gaagtctttc ttccggcggc tctcgtacgc gctgcgctac tagcccagat
    12301 tctctctggc cgtaccaatc caccgacact gtcagagtac taacaacaca ccgacccgag
    12361 taactacatc tcatcccacg agcgccacac acgaattggt gacgcgttcg tccgtgcgcg
    12421 ctatttcgac gcggcgatac acagaaaagg cattcaacga ggaggtgtcc catgtcccgg
    12481 acaggcgaat tccggatcga tacgcatcac cgcagtcgtg aggttggcta ggttcccgac
    12541 agcaaccgcc gtcagcgcga tcgcgttgag cgtcacacgc acgccgggcc tcgatgcccg
    12601 cgcggcacca ctccggcacg gccgcgacac cgtgcaggcc agctactcca cgcgggcggg
    12661 ttcgacaccg gtcgccacgc ccgcacaccg ttcgcatccg ccatcaccac actcctgatc
    12721 ctgaggaaca cctatgtcca ccacatccac tcccgtcgcc gccctaccgc gttcatcctc
    12781 gtcccgcgtt ctggtccatc gcgtcggcac tccaccggcc ggtaccgccg cggatccgcg
    12841 gtcctccatg cagtggcacc tcgatcatcg acacggcgcg cagttgacgg ccgtcccctt
    12901 cgacgtcgac gaccggtgga tcgctacctg gctcgacggc ctggccgatg tccctggcct
    12961 cgtccagatc cggtccggtg actaccgcgg ctacgacgac atgccgtact acgcgatcgc
    13021 cgacggccgt cacctcgtcc ccgaggatct cgcgctcggg cgcccgcggc tcaccgagca
    13081 ggccttcgcc gcgtatccgc atctcaccgg atcggacatt cctcgccgcc ttcaggtcag
    13141 cattccgaac gccctggatc tgagctattt cgcgtccggg tcggtcgacg ccgccacgca
    13201 ctggatgcca acgatgcaat cgatggtcag cggcgaggtg tccacactca gcgaacagtg
    13261 gggcgaccgg atcctgctgc agctggaaag tccggcgatc ctgctcgcct accacagcac
    13321 tccccgccag gactggtcgc tactgaccag tgagctggtt cgtcaggtca gcggcgttct
    13381 cggtgccgca ccgtacgccg actgggtact gcatctgtgc tacggcgatc ttgagcacac
    13441 accgctgttc gaaccgacgg atctcacggc cgcgacaatg ttcctgaacg ctctgtcgga
    13501 ccagctcgcc gaccgtgggc agcgcatgcc caccgtgcat ctgcccctga cgcacggcga
    13561 cgccgcccct ccggtggatc cgctgttcta cgcgcacctt cggcgtcttc gccggggaat
    13621 cccgatcatc gccggtctcg tcgctgagga gcacccgcac cagacctctg tcgcgtccga
    13681 gttgcttgtc ggtgcgctcg gagtcccggt ggaggccata tcggccgcgt gcgggctcgg
    13741 acgacggtcg gaaacggcgg ggaaggcgaa caccctcctg gcggccaccg tcgctctcgg
    13801 ctggaacgag cgagcggcct cataaagcga cggggacggt cccgacatct cgccaccgtc
    13861 caccagggac acccccccca gagatcacct accgaaggaa acccgtggga cgacatcgaa
    13921 tgagccctcc accgcggtcg acgcacatcg cggcgaagac cacctacatc ggccggcacc
    13981 gccggccgtc ggcaccgccg gcgatcttga cggtcgtgtc cgcgatctcc ggtgccgtga
    14041 tcgcggcggc caccgaaggc ctccacgcgg tcacctcggc aggtggcacc accccgacgt
    14101 catcggtccg tcacacccgt cggacgacgc cccagcagca gagaacacag taggaggaca
    14161 cctatgtcga tcatctacca cacgatcgca cgtatcgctg tcaccaccgc gctggccgcg
    14221 acggccgccc tcggcagcgg cactgcgacc gcgaccacgg tagcgccgtc gcccgatcca
    14281 gccaggtcct gccgggacat caccttcccc accagaaccg gtccgctcga gaccacgatc
    14341 cacggcgtcc tgtgcgcgcc gaccacccat cccatcaagg gcacccaagt actgctccac
    14401 ggtgcgacgt acaacagcca gtattgggat ccacccgtcg cgaacggcaa gtattcctac
    14461 gccaagcaga tgaacaacgc ggggtaccga acgctcgctc tggaccgcct gggcgccggc
    14521 accagctcac ggccgccgag cgtccttctc tccgtcgaca accaagccga tgccgtgcac
    14581 caagtgatca cccacctcaa agcaggtcat ctgatcgacg cccccgcccg tcgtatcgcg
    14641 cttgtcggac actcgatggg tagtgccgtg gcaacggtcg agcaaactac gttccacgac
    14701 gtcgacgccg tggtcatgac cggcgcgaca gcacacatcg acccggcgtt tctgctcacc
    14761 acactcacca actacatgat gccagcgaca ctcgacccca aattcggccc gttcagcggt
    14821 caactcgtcg acccgctcta cctcaccaca cggccaggcg ttcgcagcgc cgcgtttcac
    14881 gcggccaccg acgtcgaccc cgaagtggtt caggtcgacg aggcgaccaa ggatctggtc
    14941 gcgacaaccg agattctggg tgccatcacg aagggatggg caccagaaac gacacgtcga
    15001 atcaccgtgc ccaccatggt gcaactcggc ggagctgaca acttcttctg tccgcccggc
    15061 cgtggcgact gctcctcggc cgagaccctg gccagggccg tggaacatga tttcgcaccc
    15121 gcggcgcagc tgcacacctc gattcttccc gccgcgggcc acgatctgca gctcgctcgc
    15181 aacggcgcga ccgccgcggc cgaggtctcg tcatggatgg atcgcgcgct tccctagctc
    15241 gaccggccgc cgccacgatg ggccccggac tcgctggggt tctgcctacg ggatcggcgt
    15301 tgtcgtcgcg acatggcggc gccgatcccg ctgccgcatg cgcgccggcg aacgcgtccg
    15361 tcgcgacgcc aatctggact ccgctcgcct cctctggggc gagaaccagt actgagcccg
    15421 ggcaacgagc ggctggcagg ggatgtggcg aggttcagtt gcgttgcctg atccgcctgg
    15481 gctggtaggt cgccacgacg gcgaggtggt cggcgaggcg tttcgggtcg aggacgtcgt
    15541 cgtcaacgac ccggggctcg gcgacggtct catagttgga gagagcgggg ccgaggtcgg
    15601 gggtggtcca gacctggtcg aaccgggcga gcgggtgttc gctgccgggc cagtgcccga
    15661 ccgtcggcgt ggggtccgcg ccgcagacga ccgcggcgtc gagcatcccg gcgagcgcga
    15721 ggtgctcggt cgggcgccgg tccgccgacc aggacttggt cccggtggtg ggatcgagag
    15781 agaccgagca gtagctgtcc agcccgggtc gccatcgcgc ctggtccagg tccggatcaa
    15841 agtatgggcc gtaccaaggg ctgcctggtt cgcgcggggg cgagattcgg gcggcggaga
    15901 cgctgttgtg gtctccggcg atgagcgtgg gcgggtgccc ggcggggcgg gtcatcgccg
    15961 ccagcagccg ttcgccttcg tcggagcggc gttcgcgtcc ggtccaggac aggtgggccg
    16021 agccgtggac gaccggcgtc ttcgagccga catcgagcga cagcagtgcc aggctgtgaa
    16081 agaaattcgt accgctgatg gcgaaccagc cgccctcgac cgggctgatc ccgccgctcc
    16141 acagcagcgc ggtgtggtac tcctggttgc cgaccgcgat tgtcggcact ccggatgcgg
    16201 tcgcgcactg catacccagc gcttcgccca gcagccgcag ccgccgcccc gcaagctccg
    16261 ttttcgtccg cgggtccgcg tcggccgcga cgatctcctg caccgccagc acatgcggtt
    16321 tcaacgaccg cagcagtgcc acctgcgccc gccgccgcgg cgtgtcgagc tctgcctcgc
    16381 cgccatcgag gaacaggttg tgcaggttcg cggtgacaac gcggacgaat ccggggccgg
    16441 tcacggcccc ggctccgccg cgggcagcgc cagcacgccg gtcaggactg tcaccggcgg
    16501 accgtcgccg tgtcgtgttc gagttcggcg aggcggcgga acccatgccg ggcgaagtcg
    16561 ggcatcgacc ggtggagggc gtaggcgagg actcccgcgg agccccggag ggcgacgctg
    16621 cgcttcgcct cggcgggcca cggccggacc cgggtcggtc tcctggtcgt agccttcgac
    16681 gaacacgacc cgcagactcg gatcgtcgag ctggccgagg tcgagcaggt tgccgaagtc
    16741 gagcagcgga tgcccggtcg cggcggtttt caggtcgagc agcacgacct caccgcgtct
    16801 gtcgatcccg aggttggcga aatgcagacc acgatgcccc gaccgcagcg cgccgtccaa
    16861 cgacgtcgac gtgtcgtcgc tgccgggcca gggccggtac acggtggaag gcagcggtcg
    16921 gtcgggacca ccctcggcaa cgtcgcagga gggaatgctc accctcgcga gggtagccgg
    16981 gacgagcccg cgtcgccgcc ggtgcagcca agccgagcaa ttccctccta aagacaccga
    17041 cggcgcgagc ttggtcgacg gctcgtggct gtgcctcgaa ggagtgtcga tcctgaccgc
    17101 ctggtcggct tatggaagat gacacttccg acgtgtccgg tctgtcgttg ttggccttcg
    17161 tgtggcgtag gggccaatct ctcgacatct acccacccga acgcgaagcc ctcggcatcg
    17221 tcgcgatcgg catcggactc atcgacccgc gaactcgacg ggtgacgaga tgcggtccga
    17281 tgtggtcggc aagtaacggc aggtccgggg ttcgcgactt ctcggagacc acgcagtagt
    17341 gaggtgatcg ggacgagcga cacgtctgtc cggagtggac gcggacggcg gttgttctgg
    17401 gctgccgccc ccggcgtagg gctgcccctc gcgctggtga tgaacctgtt gatgatgatg
    17461 ctccgcgagt tcacctggtt cgggctggtc ttggcggtcg tgacggtgcc gcttgctgtg
    17521 gtggcgttct cgctcccgcg gatgcaattg cgaaccgagc ggcgcatcag caccaaccgg
    17581 atcgcccaat accaggcact gcggcagttc ctcggcacca ccacgctgtc gccagtggct
    17641 cgtcccgcgc ttccgacccc gcggtcgccg cggacatggt ggcgcatctg gcgcaccgtg
    17701 tggtcgcgca accgctccgg cctggatatc cccagcgata ccgacctcga taccttgagc
    17761 acgcgactcc gcactgcagc gacgacggca tggcgctttt ccggcagctg gcgatcctga
    17821 tgggcgccat tctgctgacc gccgagaccg accacgcccc tggacctggc aacgctgcgg
    17881 ctccccgcac cggggcttcg ctcgtggcgc tggtacggca agacctgcgg tgggaggtcg
    17941 tcgacggcgg ggcgcgcacc ccgtcgcccg gatcgtcgcc gggttcggga ggcaccccgg
    18001 tcgtgaccgg cacgatcggg caaacgctgg gccgcttctt cggcgccgtg acgcgagggt
    18061 gcgctcgggc ggcgcagtga ctagctgacc tcaccgcagg gcgaagtccc cgcccgtaga
    18121 agatactgtt gccgctctca gctcaagcac ctgccaccgt gatgctcgac gtccgggagt
    18181 gggtagctga ggacatggtg aggcggcttt agcctgtctg ccgattctgc gacgcaggaa
    18241 tgatggtggc ggcgagctgg atccggtagc gctcgctgtc caggccgtgt ctgaagcagc
    18301 tgatgtgcag gtcggtgggt agcgatgcgg cgagagtggt cgcggtgcgg gtgtcgcgcg
    18361 ggagcagcgt tcggtgcagg gcgctgagca gcaaggcggg gactctgctg gcgaccccgg
    18421 tcatgtgcgg ggaggtggcg aggaccgcgt cgacgcgcag accgggttgg agccgcatca
    18481 ggcagcggtc gtgccaggcc accgcagcgc acaacggcgt gattccgcgc gagtggccga
    18541 cggccatgct cagccaggca tcggcgtcgg cgatggcgag cttcggtgtg gcgaaccgaa
    18601 ggtgaacgtc ggcattggcg agggcccggg cccatcggat gtgccgctgg gggtgcgcgc
    18661 ccggtggtgg ttggtagccg gtggcggcca cgaaggtggc gtgtgcggtc cagtccaacg
    18721 cgtcggtgta ggaagttggg accctggtca cgatcgccat gcctgtgccg ccgggttcgg
    18781 gcggcaattc ccaggtcaca atgtcggcgg catgcccgtc gtccatgatc gggcggggtg
    18841 ctgcgctggc aggcagggcg ccgatcggat cacgtgggct gcggctacgc gggcgggggt
    18901 cgagcgcggt cagcagtacc cggacccctg ccgccacaac gctgtctgag agttgtgcgt
    18961 cgcaggtgac gggcatgtca gggtccgcgg cacgcaacag gtggtcggcg acctcggccg
    19021 cagtgggacc accgcgccag ctcagctcga tcgcgccgtg atcggtgacg cggtacgccg
    19081 tgcgaggccc gtccagcggg ccacaccgac gttgcagcgt cagcgcgagc caccccgcca
    19141 cccgttgctg atcatgccgc gatccagatt cggtcacgcc cgcacactac cgcgcacgtc
    19201 acgcccgcgg tggcgcttca cgggccgggc gcatcgtcag gcgaggcgtg tcaggcggat
    19261 gcggccacga tcgccactgc ccggcggcat agcagtgcct cgccgtgacc ggaaccgggt
    19321 gcatgcaaca agatcgaggc tcgcagccgt gacgcgccgc cgacggcggc gaggacctcg
    19381 tgcaccacgc gcgtgagcgc ctggagttcg tcgaggctgt cgcgaagggt gccggtgtag
    19441 atccaggcca ccagggtggc ggcgatctcg gtgctgtcgt tggaaagcac ggcccccagg
    19501 cagctcgcga gcgggccgtc gcccgggatc gcgtcgtccg cggtggcgcg gcggggccgt
    19561 gatcgcggct caccgccgcg cgttgcgggt cagcgggctg ttctcggccg cgtgtagatc
    19621 gatgaccagt gtggtgaggg tcgctgtgtc gccggtaccc gcggccgtga cgatcgcggc
    19681 tgccggcggg ccgccgtcac ccagcggcgg aacgatctgg tgcgtcattt gccacgtcag
    19741 caaccacatc tgctcggagc ctagggcgaa caccacgtcg attcgggtgt cgattctgcc
    19801 catctcggtc agaatgctct gcagagcaag agagtcctgg tagcgaccca ggatcctgcc
    19861 gcatcgccgc gatccgcccg gtgtggcacg cgatcactcc gaaggggccc cacttctggt
    19921 tatcggctca tcgtgccacc cccgcgcctc tacaccgctt ggaggctgtg ccgagcaccg
    19981 agaaagacaa gcaggcctct ccggatggat cgcgcctagc accgcacgtg cgctcccccg
    20041 cacgaaaacg gcttcggtgt aggtccgagt cggcccgcca cgactcgcgt cgtcgaccgc
    20101 gcgcgtccac accggcacct ccttacttca caaagttcac gcagcggcat ggcaaaaggg
    20161 cgcacgcctt cgggtgtgcg tcaccacgag ctgtacaagc tatccctacg gcttgtgcgc
    20221 gacggcgccg acgaggagtt gctcggcggg caggggctca cgggtacgcg ggccctctgg
    20281 ccaccagtcc gacagcggcg tcagcactcc agcgccgtga ggatgtggct gcacgatccg
    20341 caggccggtc agcatcgagg tgatctcgtc ccgggtgcgg aagtagcccg ctcccagcgg
    20401 gctatggacg agtacgtcct gcagccgccg ggctgtcgct gtcaacactc caccgtcctg
    20461 atcgtcctgc gggtcgcaga agtgcgacag cacgatgtac gagccactgg ggagcaggtc
    20521 gatgtagcgg cccaggatcg ccgccggatt ggcactgtcg ggaacgtaat gcagcgtgga
    20581 gacgtggagc gcggcgacgg gtcggtgcag gtcgagcagt ggcgccgtct gcttgccggt
    20641 cagcaccgcg accgggttcg tgagcgactc ctcgatcacg tggtggtcgt cgaccagcag
    20701 ggcgcgtagc cgtgcggcca cgacgggatc ctgctcgacc gacaacacgc gtgactcccg
    20761 gttcacgctc gtcacgatgt cgtggaggga ctgccccatc ggcagacccg ggccgaggtc
    20821 cacgaactgg cccactgtcc gtgccagcca ccgcgccgcc cgcagtttcc aggcccgttc
    20881 cccccgcatc accgtcgaca aacccggttc cacggtcagg gccctgtctc tgaccgcgcg
    20941 ggcggccgcc ccggcgtctt tgccgcccac catcgcgtcg gagaatcggg cgaggctca
//
