LOCUS       NZ_CP059997            21515 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 9667956
            Orig. end                         :: 9689471
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21515
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="47"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21515
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21515
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11515](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11515
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            891..2327
                     /locus_tag="HUW46_RS44635"
                     /old_locus_tag="HUW46_08847"
     CDS             891..2327
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082030.1"
                     /locus_tag="HUW46_RS44635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08847"
                     /product="aldehyde dehydrogenase family protein"
                     /protein_id="WP_215544674.1"
                     /sec_met_domain="Aldedh (E-value: 1.2e-167, bitscore:
                     557.2, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATRLFIDGQWTAARGGAIPTFDPATGKVIEEVGTASAVDVDSAV
                     YAARRALDAPEWAGLLPVQRAALLFRLADLVDKHHEELAALETRDQGQPIGVSRQVSVT
                     GAAEHLRYFAGWVTKIQGTTNPVSFPETLHYTRREPVGVNALVLPWNFPLMILVWKLAP
                     ALATGNTVVVKPSEVTPLTAIRLVELAAEAGIPPGVVNLVTGDGEVGAMLSTHPDVDHL
                     SYTGSTAVGKLITAASAESNLKRLTLELGGKAPSVIAADADIDAAVAGNLAGATLNTGQ
                     VCAAYTRFYVDRKREQEFVDKLARGLEDLQIGPGIDEGTQLGPLVSAKHREHVDVLVSI
                     GREQGAELVTGGTAVDREGYFYSPTLFAGVTDEMTIMREEIFGPVLAVTSYDDGDEVLA
                     RANDTEYGLAATVWTRDIGTAQRFANGIRAGAVFVNMPPVPDMAAPWGGYKASGWGREM
                     GPWAIDAYTETKSVWLHYGA"
     misc_feature    2404..2413
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.52"
                     /tool="antismash"
     gene            2447..3871
                     /locus_tag="HUW46_RS44640"
                     /old_locus_tag="HUW46_08848"
     CDS             2447..3871
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558403.1"
                     /locus_tag="HUW46_RS44640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08848"
                     /product="fumarylacetoacetate hydrolase family protein"
                     /protein_id="WP_215544675.1"
                     /transl_table=11
                     /translation="MTTDSDVPRRPGKIVALHLNYPSRAAQRGRTPTHPSYFLKPPTSV
                     AASGDALERPKGTELLGFEGEIALIIGKRTRRVSPENGWAHVSGVTAANDFGVYDLRYA
                     DRGSNLRAKGGDGFTPLGPSVLPARELDPEALRVRTWVNGELAQEDTTAGLLFGFGRLV
                     ADLSQLMTLEPGDVILTGTPAGASVVRPGDIVEVEVDGNGHTTGRLVTPIVDGTVPFGQ
                     YGALPRVDGRQRAEAYGTPAFELTEDLKRRLTSVGTATLSAQLRKRGYNDVSVDGLVST
                     TPGARLVGRARTLRYLPYREDLFRAHGGGYNAQKRAFDSLDSGDVLVMEARGEHGTGTV
                     GDILALRAKVRGAAGIVTDGGVRDVDAVTALGIPTYHSGAHPAVLGRRHVPWEVDVSIA
                     CGGAAVQPGDVVVGDADGVLVIPPPLVEEVVDAAIEQELQETFIAEQVAAGERVEGLYP
                     MNEEWKARYAAWLTRR"
     gene            3853..4527
                     /locus_tag="HUW46_RS44645"
                     /old_locus_tag="HUW46_08849"
     CDS             3853..4527
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558404.1"
                     /locus_tag="HUW46_RS44645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08849"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_215544676.1"
                     /transl_table=11
                     /translation="MAHEAVNSHALSKSQLAYQWIKARIGDGTFSPGYRLVLGQIAQEL
                     GVSAVPVREAIRLLEAEGLVTFERNVGAQVAMVDEIEYQHTMQTLALVEGYATALAVPL
                     PPKRIATAKKLNAELTACLDDFEPKRFTSLNREFHWALFDACPNPQVLDLVNRGWNRLS
                     GLRTSTFSFVPGRAHESVREHERILALLEQGAPPNEVEQAVREHRLATLDAFLAYQAER
                     HS"
     gene            4540..5484
                     /gene="dapA"
                     /locus_tag="HUW46_RS44650"
                     /old_locus_tag="HUW46_08850"
     CDS             4540..5484
                     /EC_number="4.3.3.7"
                     /GO_function="GO:0008840 - 4-hydroxy-tetrahydrodipicolinate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="dapA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081995.1"
                     /locus_tag="HUW46_RS44650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08850"
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="WP_215544677.1"
                     /transl_table=11
                     /translation="MRFRSDPRSVKGSIAPLMTPFTADGELDRAGLVNLVRWQLSAGSH
                     GISIGGSTGEPGAQTIAERAEAIRIVAAEVDDRVPFLPGTGSAKLDETLELTAAARDAG
                     ADAALVITPYYARPTQEALYSWYRTVALEFPDLPIVAYNVPSRTAVDIAPETVARLFRE
                     LDNFVGVKETTKDFEHFSRVLHLCGEDLLVWSGIELLCLPLLALGGAGFVSATANIAPA
                     ACAEMYEAWQSGNHARAREIHYGLHPLVDLLFVETNPAPGKWVLEQRGLIGSGFVRPPL
                     ITPTDTGIAKIKDLMAEGERFLTATEGFTVEGK"
     gene            5487..6998
                     /gene="hpaE"
                     /locus_tag="HUW46_RS44655"
                     /old_locus_tag="HUW46_08851"
     CDS             5487..6998
                     /GO_function="GO:0018480 -
                     5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
                     activity [Evidence IEA]"
                     /GO_process="GO:1901023 - 4-hydroxyphenylacetate catabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="hpaE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020661603.1"
                     /locus_tag="HUW46_RS44655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08851"
                     /product="5-carboxymethyl-2-hydroxymuconate semialdehyde
                     dehydrogenase"
                     /protein_id="WP_215544678.1"
                     /sec_met_domain="Aldedh (E-value: 7.9e-167, bitscore:
                     554.5, seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKHYVPDGLPSKIQHYIGGELVDSVSGKTFDVLDPVSNQPYVTA
                     SAGLAEDVDLAVAAARKAFVDGPWPGMLPRARAAVLNKIADAVEAQDARLAELETFDTG
                     LPITQALGQARRAAENFRFFADLVVAQADDTYRVPGRQMNYVHRKPIGVAGLITPWNTP
                     FMLESWKLAPALASGCTVVLKPAEFTPLSASLWAEIFTDAGLPEGVFNLVNGFGEEAGD
                     ALVRHPDVPLISFTGETTTGQTIFRNCAAGLKGMSMELGGKSPAIVFADADLDAALDST
                     LFGVFSLNGERCTAGSRILVERGIYDEFCARYAERARNIVVGDPHDPATEVGALVHPEH
                     YAKVMSYVELGKSEGRLLAGGGRPSGLDTGNYVAPTVFADVPPDARIFQEEIFGPVVAI
                     TPFDTEAEALSLANDVKYGLAAYLWTADLTRAHTFAQSVEAGMVWLNSHNVRDLRTPFG
                     GVKASGLGHEGGYRSLDFYTDQQAIHVSLGPVHTARFGASPKEQS"
     gene            6995..8038
                     /gene="hpaD"
                     /locus_tag="HUW46_RS44660"
                     /old_locus_tag="HUW46_08852"
     CDS             6995..8038
                     /EC_number="1.13.11.15"
                     /GO_function="GO:0008687 - 3,4-dihydroxyphenylacetate
                     2,3-dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpaD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558407.1"
                     /locus_tag="HUW46_RS44660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08852"
                     /product="3,4-dihydroxyphenylacetate 2,3-dioxygenase"
                     /protein_id="WP_215544679.1"
                     /transl_table=11
                     /translation="MTAAPPDVLRCAYAELVVTDLAASRAFYVDVLGLVVTREDEDAIY
                     LRAFEEFLHHSLVLRKGEVPALAVLAYRVRSEVDLDLAEAYYRELGVRVERRPAGATRG
                     IGEAVRIEDPLGFPVEFFHEAEHVERFTQRYDAHGAGALSRLDHFNIATPDVPVARKYY
                     EGLGFRVSEDIQDDEGTVYAAWMFRKPTVHDVALTGGDGPRLHHIAFATHERHQILHIC
                     DHLGALRRSGMIERGPGRHGVSNAFYLYVRDPDGHRIEIYTHDYYTGDPDNPVITWDVH
                     DNQRRDWWGNPVVPSWYSDASLVLDLDGQPKPVIARAEAREADVTVGADGFAYTADQEG
                     FKLGQQV"
     gene            complement(8050..8187)
                     /locus_tag="HUW46_RS44665"
     CDS             complement(8050..8187)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS44665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215544680.1"
                     /transl_table=11
                     /translation="MDEAEPVREEPRALEPEVERACWPLRAPRWWMLAPPVEAPPERPR
                     "
     gene            8477..8629
                     /locus_tag="HUW46_RS44670"
                     /old_locus_tag="HUW46_08853"
     CDS             8477..8629
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS44670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_08853"
                     /product="hypothetical protein"
                     /protein_id="WP_215544681.1"
                     /transl_table=11
                     /translation="MSDLGFTVVLIGMVLSLAMVLRVAEARLRQLDRARSGRAAARSTR
                     STVDG"
     misc_feature    8558..8560
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            8703..9245
                     /locus_tag="HUW46_RS44675"
                     /old_locus_tag="HUW46_08854"
     CDS             8703..9245
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS44675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_08854"
                     /product="hypothetical protein"
                     /protein_id="WP_215544682.1"
                     /transl_table=11
                     /translation="MPALVVSASVLQFLLAMTFAVIPVAALRHGAAAQRAAEAEVTGQG
                     FAARVLAEHQVRFAETGKEALFPFALAALLTALGAMNLAGIGVGRIASFVVAAILMTAG
                     GFVTAGQVFAARSVESAFRKSRDAAARAVDGRAVVAAAAREFPYWLRPLQVVRFALTTL
                     GSVLVIALLAAAGSYFG"
     gene            complement(9195..9905)
                     /locus_tag="HUW46_RS44680"
                     /old_locus_tag="HUW46_08855"
     CDS             complement(9195..9905)
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009950303.1"
                     /locus_tag="HUW46_RS44680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08855"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_215544683.1"
                     /transl_table=11
                     /translation="MPRDTLTREQIVEAAVAVLDAEGVDGLNMRRLGARLGAAATAVYW
                     HVKNKDDLVVLACDHVWGEIALPDPGEVGWRAAAAALATGAREMVGRHFWLVSAMGTHL
                     VYGPGKARYDDHCLGVYETAGFRGPGADQAAATVLMFVLGAAQGEAAESAWRARLRRDG
                     ADAEARVNETVERIGEIARAFPRLRERALPSPDPATEPDEDSFEFGLRVVLDGLEARLP
                     EIASRGRQQGDHQH"
     gene            10001..11515
                     /locus_tag="HUW46_RS44685"
                     /old_locus_tag="HUW46_08856"
     CDS             10001..11515
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024640.4"
                     /locus_tag="HUW46_RS44685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08856"
                     /product="prenyltransferase/squalene oxidase
                     repeat-containing protein"
                     /protein_id="WP_215544684.1"
                     /sec_met_domain="T2TS (E-value: 8e-69, bitscore: 231.7,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDFRAAANKMLEDSAADPWAWLTPSVYECARLVSDAPWLGGHA
                     ERLRFLCAGQGADGAWGQDGFAFNGTLSATEALLAVLARNEPADDVVSRDRVREIATRG
                     LAVIRDWLAPGGRYAGGAPVTIGVELIVPMLVDRLNGHLDRAGLPRLAPPAGCAIDRLA
                     QLRQDAEDGKPLPDDLWHAWEIATPAGPPWPAPHPYAGSVSCSPAGTAGWLREAPAPDS
                     PAGRFLDGLQRDRGGLVPVAAPIDLFEQAWMLNTFVWHGVGHDCPEIVLDRMEAELGEY
                     GIAGGKDLTVDGDDTAAVLNALLCHGREPSLDGLMKYWTGDHFEIYPGEPVSSPATNGH
                     TIGLLGRYVAERQEVRERFEPVLRRNVDWLLDQQDDSGSWTDFWHCSPYYATVCAVEAL
                     SVYGGGRSAEAVRRAVEWTLETRQESGGWGVRWVTAEETAYATLILRAGSGPGIAEAFD
                     AAEPVLRNEVVDETITPLWLVKDFFSPIRVVRAAVLAARHTIARAR"
     gene            complement(11523..12794)
                     /locus_tag="HUW46_RS44690"
                     /old_locus_tag="HUW46_08857"
     CDS             complement(11523..12794)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223916.1"
                     /locus_tag="HUW46_RS44690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08857"
                     /product="cytochrome P450"
                     /protein_id="WP_215544685.1"
                     /sec_met_domain="p450 (E-value: 3.3e-21, bitscore: 74.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGITDPDTYVRGVPYDELARLRHASPVARVDDFWAVLRHADVRRV
                     LRDPAVFSSQLGGTQIRDPATDGDLAYVRRMMLNMDPPEHGRLRGLLTKAFTPRAVAKL
                     TEQIETRAWELIAAVAERGECDFAKVAADLPLLTLAAVFGVPEQDRRLMYDWSNRVIGY
                     QDAEYAVSATVDTSAASAVTDLARTALAVRPSPGADGSMPDPRTRAGMPDLYAYANALG
                     EYKRSHPGHDVMSNLMRHVGDDGGRVSLAEFENLFWLFSVAGNETLRNGLPGGMLALLS
                     HPEQYRRLLADRSLLPSAVEEMLRWWTPVMHFRRTATADVRLSDVDIRAGEKVVVWFSA
                     ANRDPEVFADPDTFDIARTPNDHLTFGHGPHFCLGAHLAKVQLRAMFGAVLDLLGEVSL
                     AGDPIRLRSNFQNGLKSLPIRWAR"
     gene            12840..13568
                     /locus_tag="HUW46_RS44695"
                     /old_locus_tag="HUW46_08858"
     CDS             12840..13568
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (13-121). E-value: 1e-17.
                     Score: 56.5. Matches aSDomain:
                     nrpspksdomains_HUW46_RS44695_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644526.1"
                     /locus_tag="HUW46_RS44695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08858"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_215544686.1"
                     /sec_met_domain="PF00561 (E-value: 2.6e-13, bitscore: 49.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1e-21, bitscore:
                     77.7, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1.3e-08, bitscore:
                     34.4, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTLTMRTRGEGEPAVLLLHGLGATGAVWDRFSGLLDRRVLAPDL
                     PGHGQSAPLPQYSFATLTAAVARALSGEGPVVVAGHSLGGVLALELASGKYDVEVAGVL
                     ALGVKVEWSQDDLDRAAALAAKPARVFVTREDAEQAYLKVSGLLGIAPADPDGLRETEE
                     GWRLAMDQAAFGVGAPDMPALLAAARCPVVLAAGETDHMSRPEQLRALDPDAVTLTGLG
                     HNAHVEDPAIVRTLLARFGV"
     aSDomain        12879..13202
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS44695_Abhydrolase_1.1"
                     /evalue="1.00E-17"
                     /label="HUW46_RS44695_Abhydrolase_1.1"
                     /locus_tag="HUW46_RS44695"
                     /protein_end="121"
                     /protein_start="13"
                     /score="56.5"
                     /tool="antismash"
                     /translation="PAVLLLHGLGATGAVWDRFSGLLDRRVLAPDLPGHGQSAPLPQYS
                     FATLTAAVARALSGEGPVVVAGHSLGGVLALELASGKYDVEVAGVLALGVKVEWSQDDL
                     DRAA"
     CDS_motif       13056..13115
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS44695_0001"
                     /evalue="1.40E-08"
                     /label="NRPS-te1"
                     /locus_tag="HUW46_RS44695"
                     /protein_end="92"
                     /protein_start="72"
                     /score="27.2"
                     /tool="antismash"
                     /translation="EGPVVVAGHSLGGVLALELA"
     gene            complement(13582..14187)
                     /locus_tag="HUW46_RS44700"
                     /old_locus_tag="HUW46_08859"
     CDS             complement(13582..14187)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646316.1"
                     /locus_tag="HUW46_RS44700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08859"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_215544687.1"
                     /transl_table=11
                     /translation="MEPGRRERKKNQTRKAIAEEAARLFGERGFEAVTIAEIADAADVA
                     VGTVFNYFRSKEALFFDLADDLVARLAEAVRDLPPGPELIAAFRRWHDGELDHLLDPRG
                     HERVRRFFGTIAASATLRAYEPQLYQRYQDALEHAMAIPHPGDPTPRLLAAQLVALHRE
                     VIRTCRDHVLRGAASSTLQRQAAAVTARAFSMLRVPDA"
     gene            14252..14956
                     /locus_tag="HUW46_RS44705"
                     /old_locus_tag="HUW46_08860"
     CDS             14252..14956
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012955.4"
                     /locus_tag="HUW46_RS44705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08860"
                     /product="N-acyl homoserine lactonase family protein"
                     /protein_id="WP_215544688.1"
                     /transl_table=11
                     /translation="MTEVVSLRVFRTASVRENGLPITVCLLELRDGSHVLVDTGCPASM
                     IDDPAAPFLVTEESHVLGRLRQEGLSAADIATVVVTHFDPDHAGANDAFPGAEFVVQRE
                     QYDHACGSGLLRYEWLRAQWDGLRYRLVDGDTTLVPGVDLVASGGHVPGHQSVLVRLPE
                     TGPVLIAGDAWLAGSDPDTREISSFDHDERATRASQRALMDLADRERVAMVVYSHDPAQ
                     WTALRPAPFAYR"
     gene            15222..16511
                     /locus_tag="HUW46_RS44710"
                     /old_locus_tag="HUW46_08862"
     CDS             15222..16511
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223838.1"
                     /locus_tag="HUW46_RS44710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08862"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_215544689.1"
                     /transl_table=11
                     /translation="MGSGDRQPARRGGLRDAIVAPARWALWSQGTRAIAYCLVSELVML
                     AATVPLLHAAPPLRTDLAVFGALAALGIGQAETGMQVERLRRRVGNVPHINMTSVWTFA
                     GVLLLPPVLTAALTIVLYTHLGVRCWYRMHRVPPFRAISNATVIVLTCYLTWWLLTSAG
                     FTGMRALLDGGWAGIGVLSAAVVVYFAINALLVLPARKRIGRTPRELFGDWADNGLELA
                     TLCLGALNALAITIHPALSLLVVPPLVLLHRTVLIKQLESAASRDDKTGLFNASGWTAL
                     AERELARAQSRETTFGLLMIDLDFFKRVNDTYGHSAGDRVLRAVGAAITAHVRDHNDAV
                     GRYGGEEFLVLLPGIGDAGITGIAERIRTAINDLTVAIGEDGAAVEITGLSASIGTATY
                     PNAGTGLQRLLDAADMACYRAKNAGRNRIA"
     gene            complement(16770..17543)
                     /locus_tag="HUW46_RS44715"
                     /old_locus_tag="HUW46_08863"
     CDS             complement(16770..17543)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643411.1"
                     /locus_tag="HUW46_RS44715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08863"
                     /product="response regulator transcription factor"
                     /protein_id="WP_254125575.1"
                     /transl_table=11
                     /translation="MVKVRALGGEGVATVGGRGAPAGVLVVNGDRRAAGVLANLFSRNG
                     YEVAQAHDGYRGLELALSRRFDVAVIDRGLPVLTGLELVGRLRSAGASAPSIMLTSCAT
                     VRDRVEGLHAGADDCLGAPFDVAELLARVRALRRRNGGAQDTLRLDAARIDLRSRAVAL
                     PDGGQVPLTKQECALLAALCREPQRVFSRASLHELIFPGTQSKSIVDTYVYHLRRKLGR
                     TVVLTVHGVGYRLGAVRPVATRHSTPADPIPSAAR"
     misc_feature    complement(17667..17681)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 19.02"
                     /tool="antismash"
     misc_feature    complement(17762..17776)
                     /note="TFBS match to OsdR, Development and stress
                     management regulator, confidence: medium, score: 25.84"
                     /tool="antismash"
     gene            17822..18529
                     /locus_tag="HUW46_RS44720"
                     /old_locus_tag="HUW46_08864"
     CDS             17822..18529
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949659.1"
                     /locus_tag="HUW46_RS44720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08864"
                     /product="aspartate/glutamate racemase family protein"
                     /protein_id="WP_215544690.1"
                     /transl_table=11
                     /translation="MAANRPKVIGLLGGMSWESSAEYYRLLNELVRDRLGGLHSARCVL
                     ASLDFAEVERLQVAGRWDEAGVLLAEAAAGLEKAGAELLLICTNTMHKVADTVQANVGI
                     PLLHLADATADAVTGHGLASVGLLGTAFTMEQDFYRDRLAGHGLRVLVPPEEDRLTVHR
                     IIYDELCLGVVREESRQSYRDVIGRLVRAGAEGIILGCTEIELLISAEDSPVPVFPTTR
                     LHAEAAVTRSLAP"
     gene            complement(18533..19516)
                     /locus_tag="HUW46_RS44725"
                     /old_locus_tag="HUW46_08865"
     CDS             complement(18533..19516)
                     /EC_number="1.1.1.169"
                     /GO_function="GO:0008677 - 2-dehydropantoate 2-reductase
                     activity [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_process="GO:0015940 - pantothenate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005158979.1"
                     /locus_tag="HUW46_RS44725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08865"
                     /product="2-dehydropantoate 2-reductase"
                     /protein_id="WP_215544691.1"
                     /transl_table=11
                     /translation="MKVAVLGAGAIGAYVGAALHRGGAEVHLIARGAHLRAMRAHDVRV
                     FSPRGDFTAHPHVTGDPAEVGEADYVFLGLKANSYATCGPLLAPLLGPETAVVAAQNGI
                     PWWYFHGLTGHALEGRRVEAVDPGGAVSAVLETRRAVGCVVYCSTVVEEPGVIRHLEGT
                     RFSLGEPDGEISARCRALSAAMIAGGLKAPVESALRNDIWVKLMGNVAFNPLSALTRAT
                     MAEMCEHDETRELVAAMMTEALAIARATGSDPAVSVAKRIDGARRVGHHRTSMLQDLEA
                     GKPLEIDAIIGAVVELAELTGVPAPALRRVHEAVSLLDRTVTGSRP"
     misc_feature    19540..19558
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 27.88"
                     /tool="antismash"
     misc_feature    complement(19544..19562)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.18"
                     /tool="antismash"
     misc_feature    19714..19727
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.92"
                     /tool="antismash"
     misc_feature    19716..19729
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.06"
                     /tool="antismash"
     gene            19784..20521
                     /locus_tag="HUW46_RS44730"
                     /old_locus_tag="HUW46_08866"
     CDS             19784..20521
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020647517.1"
                     /locus_tag="HUW46_RS44730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_08866"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_215544692.1"
                     /transl_table=11
                     /translation="MSQPVSPLPERGPSGRRTAKGLLGSTAAKRVERPAPLRQVVYEAL
                     AELIINRTLEPGQHLVEADLAEYLGVSRQPVREALQRLQSEGWVDLRPAQGAFVHMPTD
                     EEADQLLSVRGVLETHSARLAAARASESDVERLWELQNVGVTALEAQDTEGLVEANAAL
                     HGFITELSGNAVLAELIGLVDRRVRWYYTPIARPRGQDAWHEHEELIKAIAAKDVPTAE
                     QIMAKHTERTRKAYHERPDAPQP"
     misc_feature    complement(21105..21118)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
ORIGIN
        1 cccgcttcgc agcaggatcg cgggagacgc cagcgctccc gcggcgagca ccacgtggtc
       61 ggccgagagc cgctccaccc tgccaccgat ttcgacggcc accccgaccg cgcgggtgcc
      121 gtcgaacagg acccggtgca cggtcgctcc cgtgtggacg gtcatccggt ccgtgaccgg
      181 atcggcgtag gcgagccagg tgttgagcct gcgcttgtcg cgcaaggtca cctgctgcac
      241 cgagaccccg tcgagccgat caccgtggta gtccgggttg tacgggacac cggtctggac
      301 cgcggcctcc acaatggact gctggatcgg gtggagcggt tcgttgcgcg cgatttcgag
      361 cagttcggac tcgatgcgct cgaacaccgg ccgcacgtcc tgccacgccc agcccggcag
      421 gccccagtcg tcgtagtccc gcggcgcgcc gcggacccag atcatcgcgt tgagcgagtg
      481 cgatccgccg agcaccttgc ccctcggcag gtgcagcctg cggttcgccg cgtgctcctg
      541 cggcaccgtg tagtagtccc agtcctcggg accgtgccac agttcccccg cgcgcgaagg
      601 atcgtggatg gccggattcg tgtccgcacc gcccgcctcg atcagcgtca ccagcgcacc
      661 cgcgtcgacg agccgcctgg cgacgaccga acccgccgaa cccgcaccca ccacgatcac
      721 gtccatggcc ccaccctggc aagacggcgg caccggcgcc ggaatccctt cgctggccgt
      781 caatcggcgt gccctgccgg acaagaccgc cgcacgcgcg gcaccggata ctcgatcaca
      841 cacgggcctc ccggtccggg gaacgcccaa gaccgccaag gagcacggga atggccacac
      901 gcctgttcat cgacggccag tggaccgccg cgcgcggtgg cgccatcccc accttcgatc
      961 ccgccaccgg caaggtgatc gaggaggtgg gtaccgcgtc ggccgtcgac gtggactccg
     1021 ccgtctacgc cgcgaggcgc gcactcgacg caccggaatg ggcgggcctg ctcccggtac
     1081 agcgcgccgc gctcctgttc cggctcgcgg atctcgttga caagcaccac gaggagctgg
     1141 ccgcgctgga aacccgcgac cagggccagc cgatcggggt ctcccgccag gtcagcgtca
     1201 ccggcgcggc cgagcacctt cgctacttcg cgggctgggt caccaagatc cagggcacca
     1261 cgaaccccgt ctcgtttccc gagaccctgc actacacgcg ccgcgaaccg gtcggggtga
     1321 acgcgctcgt gctgccgtgg aacttcccgc tgatgatcct ggtctggaag ctcgcgcccg
     1381 cgctcgcgac cggcaacacc gtggtggtca aaccgagcga ggtcaccccg ctgaccgcga
     1441 tccggctcgt ggagctggcg gccgaggccg ggatcccgcc cggggtcgtc aaccttgtca
     1501 ccggcgacgg cgaggtcggc gcgatgctga gcacgcaccc cgacgtcgat cacctgtcct
     1561 acaccggatc caccgcggtc gggaagctca tcacggcggc cagcgcggaa tccaacctca
     1621 agcggctcac cctcgaactc ggggggaagg cacccagcgt gatcgccgcc gacgccgaca
     1681 tcgacgccgc ggtcgccggg aacctggcgg gcgcgaccct caacaccggt caggtgtgcg
     1741 ccgcctacac gcggttctac gtggaccgca agcgcgagca agagttcgtc gacaagctcg
     1801 cccgcgggtt ggaggacctg cagatcgggc ccggtatcga cgaggggacc cagctcggcc
     1861 cgctggtgtc ggccaagcac cgcgaacacg tcgacgtact cgtttcgatc ggccgcgagc
     1921 agggcgcgga actcgtcacc ggcggcaccg ccgtcgaccg cgagggctac ttctactccc
     1981 ccaccctctt cgccggggtc accgacgaga tgacgatcat gcgcgaagag atcttcggcc
     2041 cggtgctggc cgtgacctcc tacgacgacg gcgacgaggt gctggcgcgc gccaacgaca
     2101 ccgagtacgg gctcgcggcg acggtctgga cgcgggacat cggtacggca caacggttcg
     2161 cgaacgggat cagggcgggc gcggtgttcg tcaacatgcc gccggtgccg gacatggcgg
     2221 cgccgtgggg cggctacaag gcgtccggct ggggccgcga aatgggcccg tgggcgatcg
     2281 acgcctacac cgagaccaag tccgtctggc tgcactacgg ggcctaggac catgcggggt
     2341 ggaaccggcc gaccgcgttc gtggtggccg ggctcaccgc gccaggcgac cgttgatcgt
     2401 atatgatttg tgatatgttc cgagctgacc aggcaggaag tcacgtatga ccaccgattc
     2461 cgacgtgccg cgacggccgg gcaagatcgt cgcgctgcat ctcaactacc cctcgcgggc
     2521 ggcgcagcgc gggcgcacac ccacgcaccc gtcgtacttc ctcaagccgc cgacctcggt
     2581 cgcggcgagc ggggacgcgc tcgaacgccc gaagggcacc gagctgctcg ggttcgaggg
     2641 cgagatcgcg ctgatcatcg ggaagcgcac ccgccgcgtc agccccgaaa acggctgggc
     2701 gcacgtctcc ggggtgaccg ccgcgaacga cttcggcgtc tacgatctcc gctacgccga
     2761 ccggggttcc aacctgcgcg ccaagggcgg cgacgggttc actccgctcg gcccgtcggt
     2821 gctgcccgcc cgcgaactcg accccgaagc gctgcgcgtg cgcacctggg tcaacggcga
     2881 gctggcccag gaggacacca ccgcgggcct gctgttcggg ttcgggcggc tggtggccga
     2941 tctttcccag ctcatgacgc tcgaaccggg tgacgtgatc ctgaccggga ccccggcggg
     3001 cgcgtccgtc gtccggccgg gcgacatcgt ggaggtcgag gtcgacggca atggccacac
     3061 gacgggccgc ctggtcaccc cgatcgtcga cgggaccgtc ccgttcggac agtacggcgc
     3121 cttgccgagg gtcgacgggc ggcagcgcgc ggaggcttac ggcacgccgg ccttcgaact
     3181 gaccgaggac ctcaagcggc ggctgaccag cgtcggcacc gccacccttt ccgcgcagct
     3241 gcgcaaacgc ggctacaacg acgtttccgt cgacgggctc gtttcgacca caccgggcgc
     3301 caggctggtc ggccgggcgc gcaccctgcg ctacctgccc taccgcgaag acctcttccg
     3361 cgcgcacggc ggcggataca acgcgcagaa gcgcgcgttc gactcgctgg attccgggga
     3421 cgtgctggtg atggaggcgc gcggcgagca cgggaccggg acggtcggcg acatcctcgc
     3481 cctgcgcgcc aaggtgcgcg gcgcggcggg gatcgtgacc gacggcggcg tccgcgatgt
     3541 cgacgcggtc accgcgctgg gcatcccgac ctaccactcc ggagcccatc ccgcggtgct
     3601 cggcaggcgg cacgtgccgt gggaggtcga cgtttcgatc gcctgcggcg gcgccgcggt
     3661 gcaaccgggc gacgtcgtgg tcggggacgc ggacggcgtg ctggtgatcc cgccgccgct
     3721 ggtcgaagag gtggtcgacg cggcgatcga gcaggagctg caggagacct tcatcgccga
     3781 gcaggtggcc gcgggtgaac gggtcgaagg cctgtacccg atgaacgaag agtggaaggc
     3841 gaggtacgcc gcatggctca cgaggcggtg aactcgcacg cgctgagcaa gtcccagctc
     3901 gcctaccagt ggatcaaagc ccgtatcggc gacggcacct tctcccccgg ttaccgcctg
     3961 gtgctcgggc agatcgcgca ggagctgggc gtgagcgcgg tgccggtgcg cgaagcgatc
     4021 cggctgctcg aagccgaagg gctggtgacc ttcgagcgca acgtcggcgc gcaggtcgcg
     4081 atggtggacg aaatcgagta ccagcacacg atgcagaccc tcgcgctcgt cgaagggtac
     4141 gcgaccgcgc tcgccgtgcc gttgcccccg aagcggatcg ccacggcgaa gaagctcaac
     4201 gccgaactga ccgcgtgcct cgacgacttc gaaccgaagc ggttcacctc gctcaaccgc
     4261 gagttccact gggcactgtt cgacgcctgc ccgaacccgc aggtgctcga cctggtcaac
     4321 cgcggctgga accggctgag cgggctgcgc acgtcgacgt tcagcttcgt gcccggccgc
     4381 gcgcacgagt cggtgcgcga gcacgaacgc atactcgcgc tcctcgaaca gggtgcgccc
     4441 ccgaacgaag tcgaacaggc cgtgcgggag caccggctgg ccacactgga cgctttcctc
     4501 gcgtaccagg ccgaacgtca cagctaggga gggaacccca tgcgattccg gtcggacccc
     4561 cggtccgtca agggctcgat cgcgccgttg atgacaccgt tcaccgccga cggcgagctc
     4621 gaccgcgccg gtctggtgaa cctggtgcgc tggcagcttt ccgcgggctc gcacggtatt
     4681 tcgatcggcg gctccaccgg tgaacccggc gcgcagacca tcgccgaacg agccgaagcg
     4741 atccggatcg tcgccgccga ggtcgacgac cgcgtcccgt tcctgcccgg taccggttcg
     4801 gccaaactgg acgagacgct cgaactcacc gcggccgcgc gggacgcggg tgccgacgcc
     4861 gcactggtga tcacgccgta ctacgcccgc ccgacgcagg aagcgctcta ctcctggtac
     4921 cgcacggtcg ccctcgagtt ccccgacctg ccgatcgtgg cctacaacgt gccgagccgg
     4981 accgcggtgg acatcgcgcc ggagacggtg gcgcggctgt tccgcgagct ggacaacttc
     5041 gtcggcgtca aagagaccac aaaggacttc gagcacttct cgcgtgtgct gcacctgtgt
     5101 ggcgaggacc tgctcgtgtg gtccggcatc gagctgctgt gcctgccgct gctcgcgctc
     5161 ggcggtgccg gtttcgtcag cgcgacggcg aacatcgcgc cggccgcctg cgcggagatg
     5221 tacgaggcgt ggcagtcggg aaaccacgcc cgcgcaaggg aaatccacta cgggctgcac
     5281 ccgctggtgg acctgctgtt cgtggaaacc aaccccgcgc ccgggaagtg ggtgctcgaa
     5341 cagcgcgggc tgatcggatc cggtttcgtg cggccgccgc tgatcacccc gaccgacacc
     5401 ggcatcgcca agatcaagga cctgatggcc gagggcgaac gattcctgac ggccaccgaa
     5461 ggcttcaccg tggaaggaaa ataggcgtgg cgaagcacta cgtacccgac ggcctgccgt
     5521 cgaagatcca gcactacatc ggcggcgaac tggtcgacag cgtgtccggc aagaccttcg
     5581 acgtgctgga cccggtgtcg aaccagccct acgtcaccgc ctcggccggg ctggccgagg
     5641 acgtcgacct cgccgtggcc gccgcgcgca aggctttcgt cgacggtccg tggcccggca
     5701 tgctcccccg cgcgcgtgcc gcggtgctca acaagatcgc ggacgccgtc gaagcacagg
     5761 acgcccgcct cgccgagctg gagaccttcg acaccggctt gccgatcacc caggcgctcg
     5821 gccaggcgcg ccgcgcggcg gagaacttcc ggttcttcgc cgatctcgtc gtggcgcagg
     5881 ccgacgacac ctaccgggtg ccggggcggc agatgaacta cgtgcaccgc aagccgatcg
     5941 gggtggccgg gctcatcacg ccgtggaaca ccccgttcat gctggagagc tggaagctcg
     6001 cgccggcact ggcttcgggc tgcacggtcg tgctcaagcc cgcggagttc accccgctct
     6061 cggcgagcct gtgggccgag atcttcaccg acgccgggct gccggagggg gtgttcaacc
     6121 tcgtcaacgg gttcggcgag gaagcgggtg acgcgctcgt ccgccatccc gacgtcccgc
     6181 tgatctcgtt caccggcgag accaccaccg gccagacgat cttccgcaac tgcgcggcgg
     6241 ggctcaaggg catgtcgatg gaactgggcg gcaagtcgcc cgccatcgtg ttcgccgacg
     6301 ccgatctcga cgcggcactg gattcgacgc tgttcggggt gttctcgctc aacggcgaac
     6361 gctgcaccgc gggaagccgg atcctcgtcg aacgcgggat ctacgacgag ttctgcgcgc
     6421 gctacgccga gcgggcgcgg aacatcgtgg tcggtgaccc gcacgacccg gcgaccgagg
     6481 tcggcgcgct cgtccacccc gagcactacg ccaaggtgat gagctacgtc gagctcggca
     6541 agtccgaggg acggctgctc gccggcggcg gccgtccgtc cggtttggac accgggaact
     6601 acgtggcgcc cacggtgttc gccgatgtcc ccccggacgc gcggatcttc caggaggaga
     6661 tcttcggccc ggtcgtcgcg atcaccccgt tcgacaccga agccgaggcg ctttcccttg
     6721 ccaacgacgt gaagtacggg ctcgccgcct acctctggac cgccgatctc acccgcgcgc
     6781 acaccttcgc gcagtccgtc gaggccggga tggtctggct caactcgcac aacgtgcgcg
     6841 atctgcggac cccgttcggc ggcgtcaagg cgtccggtct cgggcacgag ggcggctacc
     6901 gctcgctcga cttctacacc gaccagcagg cgatccacgt gtcgctcggg cccgtccaca
     6961 ccgcccgttt cggggcctca ccgaaggaac agtcatgacc gcagccccac cggacgtgct
     7021 ccgctgcgcc tacgcggaac tggtcgtcac cgatctcgcc gcgtcccgcg cgttctatgt
     7081 ggacgtgctt ggcctcgtcg tcacccgcga agacgaagac gcgatctacc tgcgcgcgtt
     7141 cgaggagttc ctgcaccatt ccctggtcct gcgcaagggc gaggtacccg cgctggcggt
     7201 gctggcctac cgggttcggt ccgaagtgga cctcgacctc gccgaggcct actaccgcga
     7261 actgggggtg cgcgtcgaac ggcgcccggc cggtgcgacg cggggcatcg gggaggccgt
     7321 gcggatcgaa gatccgctcg gcttccccgt cgagttcttc cacgaagccg agcacgtgga
     7381 gcggttcacc cagcgctacg acgcgcacgg cgccggcgca ctgtcccggt tggaccactt
     7441 caacatcgcg accccggacg tgcccgtggc gcggaagtac tacgagggac tgggattccg
     7501 ggtttcggag gacatccagg acgacgaggg cacggtctac gccgcgtgga tgttccgcaa
     7561 gccgaccgtg cacgatgtcg cgctgaccgg cggcgacggc ccgcgcctgc accacatcgc
     7621 tttcgccacc cacgaacggc accagatcct gcacatctgc gatcacctcg gcgcgctccg
     7681 gcggtccggc atgatcgaac gcggtcccgg ccgccacggc gtttcgaacg ccttctacct
     7741 ctacgtgcgc gacccggacg gccaccgcat cgagatctac acgcacgact actacaccgg
     7801 cgacccggac aacccggtga tcacctggga cgtccacgac aaccagcgcc gggactggtg
     7861 gggaaacccc gtggtgccga gctggtactc cgacgcctcg ctcgtcctcg atctcgacgg
     7921 tcagccgaaa ccggtcatcg cccgtgccga agcccgcgag gccgacgtca ccgtcggcgc
     7981 ggacgggttc gcctacaccg cggaccaaga agggttcaag ctcgggcaac aggtctgagc
     8041 cctggcgggc taacgcggtc gctccggcgg cgcctcgacc gggggcgcga gcatccacca
     8101 ccgcggcgcc cgcagtggcc agcaggcccg ctccacctcg ggttccagtg cgcggggttc
     8161 ttcgcgcacc ggctcggctt cgtccatacg ggattcctcg atcggcggcc gggtttcgct
     8221 cgcggacgcg tggattcccc atcgtggcac ggaaagccgc ccgcacccgg cgtcttgacg
     8281 ccgctttgac ggtgtcgcgt gccttgttga cgtcccaccg ccgtggcagg tgtcaacgtc
     8341 ccgtcaagtg cggcgccgcc cccgtcaaag atgcgtccgc gctcatcgga atccgccgcc
     8401 tccgggacga cgctgacggg aactcgcgac acggtgcccc gtcgcgagcc ctgcgagacg
     8461 gaggagttcg ccgacgatga gcgatctcgg gttcacggtg gtgctgatcg gcatggtcct
     8521 gtcactggcc atggtgctgc gcgtggccga ggccagatta cgccagctgg accgcgcccg
     8581 gtccgggcgg gccgccgcca ggtcaaccag gtccactgtg gacggttaac cctacttgca
     8641 cttagttcaa gttctcgcta tcttcgactt gaactaagtg caagtgatcc tgggggttca
     8701 ccgtgcctgc tctcgtcgtg tccgcgtccg ttctgcagtt cctgctggcc atgactttcg
     8761 ccgtcatccc ggtcgccgcg ctgcgccacg gcgcggcggc gcagcgggcg gccgaggcgg
     8821 aggtgaccgg gcaggggttc gccgcgcgcg tgctcgccga gcaccaggtc aggttcgccg
     8881 aaaccggcaa ggaagcgctg ttcccgttcg ccctcgccgc gctgctgacg gcgctgggcg
     8941 cgatgaacct cgccggtatc ggggtggggc ggatcgcgtc cttcgtcgtc gcggcgatcc
     9001 tgatgaccgc cggcggtttc gtcaccgccg gtcaggtctt cgccgcccgg tccgtcgaat
     9061 cggctttccg gaagtcccgc gacgcggccg cgcgagccgt cgacggccgc gccgtggtcg
     9121 ccgcggcggc acgggagttc ccgtactggc tccgcccgct gcaggtcgtc cgcttcgcgc
     9181 tgaccacgct cggctcagtg ctggtgatcg ccctgctggc ggccgcggga agctatttcg
     9241 ggtagccgcg cttccaaacc gtcgagaacg acgcgaagac cgaactcgaa gctgtcttcg
     9301 tccggctcgg tggcgggatc gggcgacggc agggcgcgct cgcgcaacct cgggaacgct
     9361 cgtgcgattt cgccgatccg ctcgacggtc tcgttcaccc gcgcctccgc gtcggcgccg
     9421 tcccgtcgca ggcgtgcccg ccacgccgac tcggccgctt cgccctgtgc ggcgccgagc
     9481 acgaacatga gcaccgtcgc ggccgcctgg tcggcacccg gcccgcggaa accggcggtt
     9541 tcgtacacgc cgaggcagtg gtcgtcgtag cgggccttcc ccggaccgta gacgaggtgc
     9601 gtgcccatcg ccgacaccag ccagaagtgc ctgccgacca tttcgcgcgc accggtcgcc
     9661 agcgcggccg ccgccgcacg ccagcccacc tcgcccggat cgggaagggc gatctcaccc
     9721 cacacgtgat cgcaggcgag caccaccaga tcgtccttgt tcttcacgtg ccagtacacc
     9781 gcggtggccg cggcaccgag ccgcgcgccg agccgccgca tgttcaagcc gtccacgccc
     9841 tcggcgtcga gcaccgccac ggcggcctcg acgatctgct ccctggtcag ggtgtcgcgc
     9901 ggcatgctcc ccagcctacc tacactccac aatggacttc gtgggaccgg ttgtgccaac
     9961 cacgcggcgg agcggcgccc ggcacggtag gaaggcgggt atgaccgacg atttccgcgc
    10021 ggcggcgaac aagatgctcg aagactcggc ggccgatccg tgggcgtggc tgacgccgtc
    10081 cgtgtacgag tgcgcacggc tggtgtccga cgcgccgtgg ctcggcgggc acgcggagcg
    10141 cttgcggttc ctgtgcgccg ggcagggcgc cgacggcgcg tggggccagg acgggttcgc
    10201 gttcaacggc accctcagcg cgacggaggc gctgctcgcg gtgctggcga gaaacgaacc
    10261 cgccgacgac gtggtgtcgc gcgaccgggt gcgggagatc gccacgcgcg ggttggcggt
    10321 gatccgcgac tggctcgcgc cgggcgggcg gtacgccggc ggcgcgccgg tcaccatcgg
    10381 ggtggaactg atcgtgccga tgctggtcga ccggctcaac ggtcatctcg accgagccgg
    10441 gctcccccgg ctggcgccac cggctgggtg cgccatcgac cggctcgcgc agctgaggca
    10501 ggacgccgag gacggcaaac cgctgccgga cgacctctgg cacgcatggg agatcgccac
    10561 cccggccgga cccccgtggc ccgcaccgca cccgtacgcg ggctcggtga gctgctcccc
    10621 cgccgggacc gcgggctggt tgcgggaagc gcccgcaccg gacagcccgg cgggccgctt
    10681 cctcgacggc ctgcagcgcg accgcggcgg cctggtcccg gtcgcggcac cgatcgacct
    10741 gttcgaacag gcgtggatgc tgaacacctt cgtctggcac ggggtcgggc acgactgccc
    10801 ggaaatcgtg ctcgaccgca tggaagccga actcggcgag tacggcatcg cgggcggcaa
    10861 ggacctgacc gtggacggcg acgacaccgc ggccgtgctc aacgcgctgc tctgccacgg
    10921 tcgcgagccg agcctcgacg gcctgatgaa gtactggacc ggcgaccact tcgagatcta
    10981 ccccggtgaa ccggtctcct cgcccgcgac caacggccac acgatcggac tgctcggccg
    11041 gtacgtggcc gagcgccagg aggtgcggga acggttcgag ccggtgttgc ggcgcaacgt
    11101 ggactggctg ctcgaccagc aggacgacag cggcagctgg accgacttct ggcactgctc
    11161 cccttactac gcaacggttt gcgcggtcga agcactgtcc gtgtacggcg gcgggcgctc
    11221 ggcggaagcg gtccgccgtg ccgtcgagtg gacactcgaa acgcgccagg agagcggcgg
    11281 ctggggcgtc cgctgggtga ccgcggagga aaccgcgtac gccaccctga tcctgcgggc
    11341 cgggtcgggg cctgggatcg ccgaggcgtt cgacgccgcg gaaccggtgc tgcgcaacga
    11401 agtcgtcgac gagaccatca ctccgctgtg gctggtcaag gacttcttct caccgatacg
    11461 ggtggtgcgg gcggccgtgc tggccgcccg ccacacgatc gcgcgagccc gctgacttcg
    11521 cctcagcggg cccaccggat cggcagggac ttgaggccgt tctggaagtt cgaccgcagc
    11581 cggatcgggt cgcccgcaag cgaaacctcg ccgaggaggt cgagcacggc gccgaacatc
    11641 gcccgcagct gcaccttggc caagtgcgcg ccgaggcaga agtgcgggcc gtggccaaag
    11701 gtcaggtggt cgttcggggt acgggcgatg tcgaaggtgt ccgggtcggc gaagacctcg
    11761 ggatcgcggt tcgccgcgga gaaccagacc accaccttct caccggctct gatgtccaca
    11821 tcggacagcc ggacgtcggc ggtcgccgtg cggcggaagt gcatcaccgg cgtccaccag
    11881 cgcagcatct cttcgaccgc cgacggcagc agcgaccggt cagccagcag ccgccggtac
    11941 tgctcggggt gcgagagcag cgccagcatt ccgcccggca gcccgttgcg cagggtttcg
    12001 ttgcccgcca cggaaaacag ccagaacagg ttctcgaact cggcgaggga gacacggccg
    12061 ccgtcgtcgc cgacgtgccg catcaggttg ctcatcacgt cgtggcccgg gtgcgagcgc
    12121 ttatactcgc cgagggcgtt cgcgtacgcg tagaggtccg gcatcccggc gcgcgtccgc
    12181 gggtccggca tcgagccgtc cgcgccggga gacgggcgga cagcgagcgc ggtccgcgcc
    12241 aggtcggtca ccgccgaagc ggcagaagtg tccacggtgg cgctgaccgc gtactcggcg
    12301 tcctggtagc cgatcacgcg gttgctccag tcgtacatca gccgccggtc ctgctccggc
    12361 accccgaaca ccgcggcgag ggtgagcagc ggcagatcgg cggcgacctt cgcgaaatcg
    12421 cactcgcctc gttcggcgac ggccgcgatc agctcccacg ctcgcgtctc gatctgctcg
    12481 gtcagcttcg cgacggcacg cggcgtgaac gccttcgtga gcagcccgcg cagcctgccg
    12541 tgctcgggcg gatccatgtt gagcatcatc cggcgcacgt acgccagatc cccgtcggtg
    12601 gcggggtcgc ggatctgcgt cccgccgagc tgcgaggaga acaccgccgg atcgcgcagc
    12661 acccgccgca cgtcggcgtg ccgcagcacg gcccagaagt cgtcgacgcg cgccaccggc
    12721 gacgcgtgcc gcagccgcgc cagctcgtcg tacgggacac cccgcacgta ggtgtccgga
    12781 tcggtgatcc ccacggaccg accctagcgg cgccgggccg tctcgggcag gctccccgca
    12841 tggacacgct caccatgcgc acccgcggcg aaggcgaacc agccgtcctc ctcctgcacg
    12901 gcctcggcgc gaccggcgcc gtgtgggacc ggttctccgg gctgctcgac cggcgcgtcc
    12961 tggcgcccga cctgcccggc cacggccagt ccgctcccct accgcagtac agcttcgcca
    13021 cgctcaccgc ggccgtagcg cgggcgctgt ccggcgaggg cccagtggtc gtcgccgggc
    13081 attcgctggg cggcgtgctc gcgctcgaac tcgcgtccgg caagtacgac gtcgaggtcg
    13141 ccggcgtact tgccctcggc gtgaaagtgg agtggagcca ggacgatctc gatcgcgcgg
    13201 cggcgctcgc ggccaaaccc gcacgcgtct tcgtgacgag ggaagacgcc gaacaggcct
    13261 acctcaaggt ctccgggctg ctcgggatcg cacccgccga cccggacggg ctccgcgaaa
    13321 ccgaagaggg ctggcgcctc gcgatggacc aggccgcgtt cggcgtcggc gcaccggaca
    13381 tgccggcgct gctcgccgcg gcacgctgcc cggtcgtgct ggccgcgggc gaaaccgacc
    13441 acatgagccg tcccgagcag ctacgcgccc tcgatccgga cgcggtcacc ctcaccggcc
    13501 tcgggcacaa cgcccacgtc gaagacccgg cgatcgtccg caccctgctg gcgcgcttcg
    13561 gagtctgagc actacgccgc tctaagcatc gggcacgcga agcatcgaaa aggcacgagc
    13621 ggtgacggcg gcggcctgcc gctggagggt cgaggacgcg gcgccacgaa ggacgtggtc
    13681 gcggcacgtg cggatcactt cccggtgcag ggcaaccagt tgcgcggcca gcaggcgcgg
    13741 ggtcgggtcg cccgggtgcg gtatcgccat ggcgtgttcg agcgcgtctt ggtagcgctg
    13801 gtagagctgg ggttcgtagg cgcgaagcgt ggcactggcg gcgatcgtgc cgaagaagcg
    13861 ccgcactctc tcgtgtccgc gggggtcgag caggtgatca agttcgccgt cgtgccatcg
    13921 acggaacgcc gcgatgagct ccggccccgg cggcaggtcc cgcacggctt cggccaagcg
    13981 ggcgacgagg tcgtcggcga ggtcgaagaa cagcgcctcc ttgctccgga agtagttgaa
    14041 cacggtgccg acggcgacat ccgcggcgtc cgcgatctcg gcgatggtca ccgcttcgaa
    14101 accccgctcc ccgaacaggc gcgcggcctc ttcggcgatg gccttgcggg tctggttctt
    14161 cttgcgctca cgacggcccg gctccacccc ggcagcctat cgcccatctg aaccattgca
    14221 aatttgtagt cgttcatgtt tatcctcggt catgaccgag gtggtttccc tgcgcgtgtt
    14281 ccgcaccgcg tccgtccgcg aaaacgggct gccgatcacc gtctgcctgc tcgaactccg
    14341 cgacgggagc cacgtcctcg tcgacaccgg ctgtcccgcg tcgatgatcg acgaccccgc
    14401 ggccccgttc ctggtgaccg aggaatcgca cgtgctcggc aggctccgcc aggaaggcct
    14461 gagcgcggcc gacatcgcga ccgtcgtcgt gacgcatttc gatcccgacc acgccggggc
    14521 gaacgacgcc ttccccggcg cggagttcgt ggtgcagcgc gagcagtacg accacgcgtg
    14581 cgggtccgga ctcctgcgct acgaatggct ccgggcgcag tgggacgggc tgcgctaccg
    14641 gctcgtggac ggcgacacca ccctcgtgcc cggtgtcgac ctcgtggcga gcggtggtca
    14701 cgtacccggc caccagtccg tgctcgtccg gctgcccgag accgggccgg tgctcatcgc
    14761 gggcgacgcc tggctcgccg gctctgaccc ggacaccagg gagatctcgt cgttcgacca
    14821 cgacgagcgg gccacgcgag cgagccagcg ggcgctgatg gacctggcgg accgggagcg
    14881 ggtggcgatg gtcgtctaca gccacgatcc cgcacagtgg acagcattgc gcccggcgcc
    14941 gttcgcctac cgctgagcgg ttccggaatt cgccgtcggt gatgctggcg ccgagcgggt
    15001 cgcactgtcc atagttggac gggcggaccg gccaatcacc gctgaccggc cggcccgcga
    15061 atggtgtccg ccgcgacggc ggacccggtc gacgaaggga aaccgatgtc gctcagtttt
    15121 cacggttgcg catgggggca ccccctctcc aacgccgtga cctggtgcga cggcgtgcgg
    15181 gtcgccgcgc acgccggctc cggtgagccg gtgcggtgag tatgggcagc ggtgatcgac
    15241 agccggccag acggggcggt cttcgtgacg cgatcgtcgc tccggcccgg tgggcgctgt
    15301 ggtcgcaggg gacgcgcgcg atcgcctact gcctggtttc cgaactcgtg atgctcgcgg
    15361 cgacggttcc gctgctgcac gccgccccgc cgctgcgcac cgatcttgcg gtcttcggcg
    15421 cactggcggc gctcggcatc ggccaagccg agacgggcat gcaggtcgag cggctccgcc
    15481 gccgggtcgg caacgtgccg cacatcaaca tgacctcggt ctggaccttc gccggggtgc
    15541 tgctgctccc gccggtgctg accgccgcgc tgacgatcgt gctctacacc cacctcgggg
    15601 tgcggtgctg gtaccgcatg caccgggtac cgccgttccg cgcgatcagc aacgcgaccg
    15661 tcatcgtgct cacctgctac ctgacctggt ggctgctcac ctcggccggg ttcaccggaa
    15721 tgcgcgcgct gctggacggc ggctgggccg ggatcggcgt gctcagcgcc gccgtcgtgg
    15781 tgtacttcgc catcaacgcg ctgctggtgc tgcccgcgcg caagcggatc ggccgcaccc
    15841 cgcgcgagct gttcggggac tgggcggaca acgggctcga actcgccacc ctgtgcctcg
    15901 gcgcgctcaa cgcgctcgcg atcacgatcc accccgcgct cagcctgctg gtggtgccgc
    15961 cgctcgtgct cctgcaccgc acggtgctga tcaagcaact cgaatccgcc gcgtcccgcg
    16021 acgacaagac cgggttgttc aacgcctccg gctggaccgc cctcgccgaa cgcgagctgg
    16081 cgcgggcgca gagccgcgaa acgacgttcg gtctgctgat gatcgacctg gacttcttca
    16141 agcgggtcaa cgacacctac ggccattccg ctggcgaccg cgtgctccgc gccgtcggcg
    16201 cggcgatcac cgcgcacgtg cgggaccaca acgacgccgt cggccgctac ggcggcgagg
    16261 agttcctcgt gctgctcccc gggatcggcg atgccgggat caccggtatc gccgaacgca
    16321 tccgcaccgc gatcaacgac ctcaccgtcg ccatcggcga agacggcgcg gcggtcgaga
    16381 tcaccggact ctccgcgtcc atcggcacgg cgacctaccc gaacgcgggc accggcctcc
    16441 agcgcctgct cgacgccgcc gacatggcct gctaccgagc caagaacgcc ggacgcaacc
    16501 gaatcgcgta gttttctatc ggtcggcaaa atttgcgctg ccagggcgcg gctcccggct
    16561 tgacccgccg gtttgtcgcg gggtgcgccc tgccatcgca aatttagagg gcccaggggg
    16621 ccctgcgacc gactgcacgc ttccgccgcg cggggcgcgt cggatcgccg ggtgcgtggc
    16681 tgggttggga gtggccgggc cttcggcccg gacctcgcgg cactcggatg tgtaggcggg
    16741 cgagtggatt tccaggtgcg ccagcggctt tagcgggcgg cggaggggat cggatcggct
    16801 ggggtgctgt gtcgcgtggc gacggggcgt acggcgccga gccggtagcc gacgccgtgc
    16861 acggtcagca cgaccgtcct gccgagcttg cgccgcaggt ggtagacgta agtgtccaca
    16921 atggacttcg actgggtgcc ggggaagatc agctcgtgca ggctcgcgcg cgagaacacg
    16981 cgctgcggct cccggcacag cgcggccagc agcgcgcact cctgcttcgt cagcggcacc
    17041 tgcccgccgt cgggaagggc gaccgcccgg ctgcggaggt cgatccgcgc cgcgtccagc
    17101 cggagcgtgt cctgcgcgcc cccgttccgc cgccgcagcg cgcgaaccct cgccagcagc
    17161 tcggcgacgt cgaacggggc accgaggcag tcgtccgcgc ccgcgtgcag gccctcgacc
    17221 cggtcacgga cggtcgcgca cgaggtcagc atgatcgacg gcgcggacgc gccggccgac
    17281 cggagcctgc cgaccagctc caacccggtg agcaccggca acccgcgatc gatgaccgcg
    17341 acgtcgaacc gccgcgacag cgccagttcc agcccccggt agccgtcgtg cgcctgcgcg
    17401 acctcgtatc cgttgcggga gaacaggttc gccagcacac cagcggcgcg gcggtcaccg
    17461 ttgaccacca gcaccccggc cggcgccccg cgtccgccca ccgtcgccac cccttctccc
    17521 ccgagtgccc tcaccttcac caccgagacc ggctccatcg cttcccatct cccacctcag
    17581 cgcgatcgga ggcagctcga cggggcccgt ccgacaccgg ccccgcccgc gcctgctggc
    17641 acttctggta tcagctcagt cacgctatcg atgcagttga ttcttcaacc agcgttggaa
    17701 cctgtcgatt tcctatcggg gttcgttgac gccgcaccga agatccacag gaccttcttc
    17761 gacggccgga cggcccatcc cccggcggcg gatggcggtg tgcggcgggc aagatgtggg
    17821 catggccgcg aatcgtccga aggtgatcgg actactgggt gggatgagct gggagagcag
    17881 cgccgagtac taccggctgc tcaacgaact cgtgcgcgat cggctcggcg ggctgcactc
    17941 cgcacgctgc gtcctcgcct cgctggactt cgccgaggtg gaacggctgc aggtcgccgg
    18001 gcgctgggac gaggcgggcg tactactggc ggaagccgcc gcgggactgg aaaaagcggg
    18061 cgcggagctc ctgctgatct gcaccaacac gatgcacaag gtggcagaca ccgtgcaggc
    18121 gaacgtcggg attccgttgc tgcacctcgc cgacgccacc gccgacgcgg tgaccgggca
    18181 tgggctggcc tcggtcgggc tactcggcac ggcgttcacc atggagcagg acttctaccg
    18241 cgatcgcctc gccgggcacg ggttgcgcgt gctcgtcccg cccgaggagg accggctgac
    18301 cgtgcaccgg atcatctacg acgagctgtg cctcggcgtg gtgcgagaag aatcgcgcca
    18361 gtcctaccgg gacgtgatcg gcaggctcgt gcgagcgggc gcggagggaa tcatcctcgg
    18421 ctgcaccgaa atcgagctgc tgatctccgc cgaggacagc ccggtgcccg tgtttcccac
    18481 cacccggttg cacgccgaag cggcggtcac ccgctcgctc gccccctgac cgtcacgggc
    18541 gggaaccggt gacggtgcgg tccagcaacg agaccgcttc gtggacgcgc cgcaacgccg
    18601 gggccgggac tccggtgagc tcggccagtt cgaccaccgc cccgatgatc gcgtcgatct
    18661 ccagcggttt ccccgcttcg aggtcctgca gcatcgaggt cctgtggtgc ccgacgcggc
    18721 gcgcgccgtc gatgcgcttg gccaccgaca ccgcggggtc gctgccggtc gcacgggcga
    18781 tcgcgagcgc ctcggtcatc atcgcggcca ccagctcgcg ggtctcgtcg tgctcgcaca
    18841 tctccgccat ggtggccctc gtcaacgcgg acaacgggtt gaacgccacg ttgcccatca
    18901 gcttgaccca gatgtcgttg cgcagagccg attccaccgg cgccttcaac ccgcccgcga
    18961 tcatcgccgc gctcaacgcc cggcaccgcg cggaaatctc gccgtccggc tcgccgaggg
    19021 aaaaccgcgt gccttcgagg tgccggatca ccccgggctc ctcgacgacc gtggagcagt
    19081 agacgacgca gccgacggcc cgccgcgttt cgagcaccgc gctgaccgcg ccgccgggat
    19141 cgaccgcttc gacccggcgg ccttcgagcg cgtgcccggt cagcccgtgg aagtaccacc
    19201 acgggatccc gttctgcgcg gcgaccaccg cggtctccgg cccgagcagc ggggcgagca
    19261 ggggcccgca cgtcgcgtag gaattcgcct tcaggccgag gaagacgtag tcggcttcgc
    19321 ccacctcggc gggatcgccg gtgacgtgcg ggtgcgcggt gaagtcgcca cgcgggctga
    19381 acacccgcac gtcgtgcgcg cgcatcgccc gcaggtgcgc tcccctggcg atcaggtgga
    19441 cctcggcacc gccgcggtgc agcgcggctc cgacgtaggc gccgatcgcg cccgctccga
    19501 gaacagcgac cttcatgacg cgccctccca ggtcatcctt gattgcatac agtataccga
    19561 gtgtcattca gaagccaggc ctggtcgatc cgaggctccg acaccacccg gacagaccac
    19621 ccgagcgcga caaatggtgc acggcgggtc acgcaccctg cccggagttg cgccagctcg
    19681 ggacaaacgg gcactcccgc gtgtgatttt gggattttgc ataccaaaac ctgtatcctg
    19741 gaacgagatc cgccgcccct ttcacccttt gtcgaggtgt cccgtgagcc agcccgtttc
    19801 ccccttgccc gaacgcggcc cgtccgggcg ccgcacggcc aaaggtctgc tcgggtcgac
    19861 cgcggccaag cgcgtcgaaa gacccgcccc gctgcgccag gtcgtgtacg aagcgctcgc
    19921 cgagctgatc atcaaccgca cgctcgaacc gggacagcac ctggtcgaag ccgatctcgc
    19981 ggagtacctc ggcgtgagca ggcagccggt gcgagaagcg ctccagcgac tgcaaagcga
    20041 gggctgggtc gatctgcgcc ccgcacaggg cgcgttcgtg cacatgccga ccgacgaaga
    20101 ggccgatcaa ctgctgagcg tgcgcggcgt gctggaaacg cattccgccc gcctcgccgc
    20161 ggcacgcgcg agcgaaagcg acgtcgagcg cctgtgggaa ctgcaaaacg tcggcgtgac
    20221 cgcgttggag gcccaggaca ccgaagggct cgtcgaggcc aacgcggcgc tgcacgggtt
    20281 catcaccgaa ctgtccggga acgcggtgct cgccgagctg atcgggctcg tcgaccggcg
    20341 cgtccgctgg tactacacgc cgatcgcccg gccgaggggg caggacgcct ggcacgagca
    20401 cgaggagctg atcaaggcga tcgcggccaa ggacgtcccc acggccgagc agatcatggc
    20461 gaagcacacc gagcggacga ggaaggccta ccatgaacgc ccggatgcgc cccagccgtg
    20521 agtgcacacg gccagggcgc ctccccggcg gccggggtca gccgcccgcg gtcgcgggcg
    20581 gccgcgccac cagcccgatt tcggcgggct ggtggcgctc ccggcctggc tggcgcagga
    20641 acagcgtcag caccgcggag agcagtgcga tggatccggc gagaacgtag gcaccggtgt
    20701 agccccacgc gctgatcacg ccggcggcga ccccgccgcc gccgaccccg ccgacgagtt
    20761 tcgcgctgta gaccagtccg tagttcgagg cgttgttgtt ctccccgaag taatccggta
    20821 ccagtgccgc gaacaacggg tagaaggcgc cgccgccgaa cccgttcacg aaggcgaaaa
    20881 ccatgaacag cacgaggttg tgcgtgttcc cggcgtagag cagaccgaac tggccgatgg
    20941 cggcgatcac cagcaccgcg gtgagcgtct gccgccgccc gatcttgtcc gagacccagc
    21001 cgacgacggc ccggccggtg ccgttgacga tggagagcac ccccgccgac gacgccgcga
    21061 cgaacgcgcc gaaatggctc tcgcccgcga agtcgacctg gaagttgatc ccgaacagcg
    21121 atacgccgcc gatgatcacc agcgacaccc acatgagcgg gagcatgccg gtcctgatcg
    21181 cctccatcgg cgtgtactgc ttcaccgcgg gcgggttctt cgccaggccc gcggcaccgg
    21241 acctgttgcg cgcccaggaa atcgggtcga cctccttcgg ccaccagctc ttcggcgggt
    21301 ccttgaacag gaacccgcag acgccgacga ggaccagcat gtacaggccg acgctgtcga
    21361 gcatcacggt gacgttcccc ggtccgagca gcgcgctgaa caggtagatg aacggcaccg
    21421 agccgtaggc gaagccgccg ttcacgaacc cggtgcgcgc gccgcgcttt tccgggtacc
    21481 acttgccgac catgttgatg caggtcgcgt acacc
//
