LOCUS       NZ_CP059997            21104 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8400016
            Orig. end                         :: 8421120
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21104
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="39"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21104
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21104
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11104](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11104)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            477..1763
                     /locus_tag="HUW46_RS39585"
                     /old_locus_tag="HUW46_07873"
     CDS             477..1763
                     /EC_number="2.8.1.7"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0031071 - cysteine desulfurase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006534 - cysteine metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (33-414). E-value: 1.2e-138.
                     Score: 454.0. Matches aSDomain:
                     nrpspksdomains_HUW46_RS39585_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333169.1"
                     /locus_tag="HUW46_RS39585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07873"
                     /product="cysteine desulfurase"
                     /protein_id="WP_215543805.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.7e-137, bitscore:
                     457.4, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.1e-07,
                     bitscore: 29.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTANSLPIEVDAIRADFPILSRTVRDGKPLVYLDSGATSQRP
                     TQVLDAERRFLETSNAAVHRGAHQLAEEATDAYEYARARTAEFVGVSPQELVFTKNATE
                     GINLVAFAMSNAATAGPESERFRVGPGDEIVVTEMEHHANLVPWQQLCQRTGATLRWFG
                     VTADGRLDLSTVDELITERTKVLAFTHQSNVLGTVNPVKLLTEKAKKVGALTVLDACQS
                     VPHSPVDFADLGVDFAVFSAHKMLAPSGIGVLYGRRELLEAMPPFLTGGSMIELVKMEG
                     TTFAPPPQRFEAGSPMTSQAVGLGAAVDYLSVVGMERVAAHEHVLTEAALAGLGGIDGV
                     RIIGPTDTVDRGGAVSFVIDGVHPHDAGQVLDSLGIAVRVGHHCAWPLHRSCSVPATVR
                     ASFYLYNTLSEVDALVSGVREAQKFFGVV"
     aSDomain        576..1718
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS39585_Aminotran_5.1"
                     /evalue="1.20E-138"
                     /label="HUW46_RS39585_Aminotran_5.1"
                     /locus_tag="HUW46_RS39585"
                     /protein_end="414"
                     /protein_start="33"
                     /score="454.0"
                     /tool="antismash"
                     /translation="VYLDSGATSQRPTQVLDAERRFLETSNAAVHRGAHQLAEEATDAY
                     EYARARTAEFVGVSPQELVFTKNATEGINLVAFAMSNAATAGPESERFRVGPGDEIVVT
                     EMEHHANLVPWQQLCQRTGATLRWFGVTADGRLDLSTVDELITERTKVLAFTHQSNVLG
                     TVNPVKLLTEKAKKVGALTVLDACQSVPHSPVDFADLGVDFAVFSAHKMLAPSGIGVLY
                     GRRELLEAMPPFLTGGSMIELVKMEGTTFAPPPQRFEAGSPMTSQAVGLGAAVDYLSVV
                     GMERVAAHEHVLTEAALAGLGGIDGVRIIGPTDTVDRGGAVSFVIDGVHPHDAGQVLDS
                     LGIAVRVGHHCAWPLHRSCSVPATVRASFYLYNTLSEVDAL"
     gene            1767..2228
                     /locus_tag="HUW46_RS39590"
                     /old_locus_tag="HUW46_07874"
     CDS             1767..2228
                     /GO_function="GO:0005198 - structural molecule activity
                     [Evidence IEA]"
                     /GO_process="GO:0016226 - iron-sulfur cluster assembly
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018686144.1"
                     /locus_tag="HUW46_RS39590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07874"
                     /product="SUF system NifU family Fe-S cluster assembly
                     protein"
                     /protein_id="WP_215543806.1"
                     /transl_table=11
                     /translation="MNLESMYQEIILDHYKNPHGRGLRDPFDAESFQVNPTCGDEVTLR
                     VKIDGDKVADVSYEGQGCSISQASTSVLTDLVVGRTVDEAFGTMDAFVELMQGRGQVEP
                     DEEVLEDGIAFAGVAKYPARVKCALLGWMAFKAAVADSGVAATTTTPKE"
     gene            2235..2648
                     /locus_tag="HUW46_RS39595"
                     /old_locus_tag="HUW46_07875"
     CDS             2235..2648
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015785966.1"
                     /locus_tag="HUW46_RS39595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07875"
                     /product="metal-sulfur cluster assembly factor"
                     /protein_id="WP_215543807.1"
                     /transl_table=11
                     /translation="MTDETQTTEVPEHREGRTAADLPEQQANPGADVAKIEDLEEAMRD
                     VVDPELGINVVDLGLVYDIHVDDDNTATIDMTLTSAACPLTDVIEDQTASVLVGSAGLV
                     KDFRINWVWMPPWGPEKITEDGREQLRALGFTV"
     gene            2834..3595
                     /gene="lepB"
                     /locus_tag="HUW46_RS39600"
                     /old_locus_tag="HUW46_07876"
     CDS             2834..3595
                     /EC_number="3.4.21.89"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006465 - signal peptide processing
                     [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="lepB"
                     /inference="COORDINATES: protein motif:HMM:NF021981.4"
                     /locus_tag="HUW46_RS39600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07876"
                     /product="signal peptidase I"
                     /protein_id="WP_215543808.1"
                     /transl_table=11
                     /translation="MTESNFPPPPRRRFSRRLALALVLAVAGLVVGIVGVVKVLGYETF
                     DYDRTTMAATMPASGKAIVSPVPPSALHRGDIVVFDLSAYPGGKASGPTMKRVIGVGGD
                     TVACCEAGTRLTINGKAVTEDYVRPAGYADQSFSVKVPEGTVFVAGDQRDSSDDSRTYA
                     TAASSGGIPLGKISGVVVGTGSIFSAQALDPTKAFTAAGLPGTPVRDTGYRTGSWFMIG
                     GLAVFVVALIAALVVRSSGRRRTAGEDPPAR"
     gene            complement(3525..5477)
                     /locus_tag="HUW46_RS39605"
                     /old_locus_tag="HUW46_07877"
     CDS             complement(3525..5477)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333175.1"
                     /locus_tag="HUW46_RS39605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07877"
                     /product="AarF/UbiB family protein"
                     /protein_id="WP_215543809.1"
                     /transl_table=11
                     /translation="MTSLLYGLLSLPFFVLMLWPLVVASRRVLGVRIGTLRTLVGAGFG
                     WAVAGSVLYSVRGAWSRETFAGLLIPIAGCAFLTTLLFLFVAEMAVPSGGGLGLLGRLR
                     AVKGRFSRARRYSQITRIAVRHGLGPYLTGRRATGDVRHAKLARSLRKALEEGGVTFVK
                     LGQVLSTRPDVLPPVFIDELSKLQDQVAHAPVDEIERLLREELGAAPDEIFAEFDREPI
                     AAASIAQVYRARLKSGTDVVVKVQRPGIEKKVDRDLDIVRRVAESLQRRAKWARALGVV
                     DLAEGFAEALAEELDFRVEARNLGAVRAAYTGDAIALPRVHSRLSTDKVLVMDRLDGTP
                     LGSSGGRIPDGDRAPLARALLDCLLRQVMLHGVFHADPHPGNVLLLANGKLGLLDFGSV
                     GRLDSGLRGGLQQLMLAIDRADPAALRDGLLEIVDRPDDIDEQRLERALGALVAKHFSH
                     GEAPDVEMFTDLFRIVAEFGLAIPPAIAAVFRALATVEGTLALLAPGFNIVVESRAFAD
                     AQIGARMRPETLRDTATEELLSLLPVLRRIPRRIDRITGALEQGRLSVNVRLFADERDR
                     DVVTGLVHEMLLAFVGAATGVMAVLLLASTGGPRVADDLTLNQVFGYNLLVISALVGLR
                     LLFVVFRWSAQRARR"
     gene            5688..6224
                     /locus_tag="HUW46_RS39610"
                     /old_locus_tag="HUW46_07878"
     CDS             5688..6224
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009077425.1"
                     /locus_tag="HUW46_RS39610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07878"
                     /product="snapalysin family zinc-dependent metalloprotease"
                     /protein_id="WP_215543810.1"
                     /transl_table=11
                     /translation="MSASTGRRAAAGLVIAGAALAAQLLGGGPANAAPTVTTLHYDSSG
                     APDYVAQIDQGAENWNNAVKNVKLEKGGSATIIIHETHDGKGSYTQTDGHGHGDIYIDS
                     TQVDEGNDPTRIAAHEIGHNLGLPDHYEGPCSELMSGHGPGTSCKNAKPDANESAKVDE
                     NFANGLATVVKTFRD"
     gene            6298..7539
                     /locus_tag="HUW46_RS39615"
                     /old_locus_tag="HUW46_07879"
     CDS             6298..7539
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672748.1"
                     /locus_tag="HUW46_RS39615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07879"
                     /product="histidine kinase"
                     /protein_id="WP_215543811.1"
                     /transl_table=11
                     /translation="MALRRVLGPVVSRSTYRGWIYLVVGGAMLVPYLLLVAVVVPMVLP
                     VVLEVPKAFVVSCVLALLVLAGTTLLSPVRVLEGTAVRELLGDPVPDAVFGPVHDWRQR
                     WRSGAMVVVHVLVGGVLSTISLLVPIAVGLSIAGPFTGRLALGSDQSALEVPKGWAGIW
                     VPLVALLGALVFLYVVAGSVRLLAMTATRLLDVSPSERIAQLERRTERLAERNRLAREL
                     HDSVGHALSVVTIQAGAARRTLRRDPDFTERALTAIEDSARAALDDLDHVLGLLREETS
                     GKAPQASLGELPALLSATRLAGVEVESEVTGELAALPPVVSREAYRIVQECLTNVVRHA
                     GKVPVTLRVAVGESRLDLLVRNPLGQQAPAERRGGGRGLRGMAERVDVLRGELHAGRAG
                     EHWEVGVKLPWGAV"
     gene            7536..8189
                     /locus_tag="HUW46_RS39620"
                     /old_locus_tag="HUW46_07880"
     CDS             7536..8189
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005455783.1"
                     /locus_tag="HUW46_RS39620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07880"
                     /product="response regulator transcription factor"
                     /protein_id="WP_215543812.1"
                     /transl_table=11
                     /translation="MTGVLLVDDEELIRAGLRAILDSEPDIEVLGEAGDGAEVAGMVAR
                     LRPDVVLMDVRMPKVDGIRATTHLLSTMDEPPKVVVVTTFENDDYVYDALLAGASGFLL
                     KRARPEEIVTAVRTVVTGESLLFPAAIRRLAEAHRPREKGRDALAKASLTERESEVLTL
                     MAAGLSNVEIAGKLFLGVQTVKTHVGNVLAKLGARDRTQAVIRAYESGFITPAC"
     gene            complement(8173..9894)
                     /locus_tag="HUW46_RS39625"
                     /old_locus_tag="HUW46_07881"
     CDS             complement(8173..9894)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020421253.1"
                     /locus_tag="HUW46_RS39625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07881"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_215543813.1"
                     /transl_table=11
                     /translation="MAVSPSVRFAFQPLYSLHTGGVVALEALARPSKGSANELLDHARR
                     ERRLVEVDVALAAGAVRYEAEQQTLLPLHLNLTAATAAAPESALDPLLDALAKVGRRPR
                     EVVLELGPPFTTTWPEQLLSGMKRLGDLGFRLALDGLGRSDLPLTLLATAPVDVLKLDR
                     SLLQRLPGEPGAIAVVEALLHYASRAQARLVATGVETDAQLDIVRELGVRIAQGNLFGA
                     AGEDTQWIGVRTAATLEPGQHRTTGGGAVPSKRVGDFLRQASTLPHTATCEDVRTVLAA
                     DDGPSGIVGVDDDNRPQWSIDRTRFLLAVTGPYGHALHAKRSADRLADSPHTIHTEAGA
                     LEFLELVTDADWSRTGDDVVVVDDDGRCLGVVLVTEVVRGVAEAKVEAAAALSPLTRLP
                     GSETVARDVDRRIACREPFVAAWLDVDSFKSVNDNAGFAAGDDLIRALGRTLTDLEARL
                     SKMTVSHVGGDDFLIACDVDEISTVASALLDTPWSAEGMAVTVSLATLVCSTATISTYR
                     EASRMLAPLKKRAKAVAGSSWVLGRPDSDRIDVLRGLTRTRTALPVPRDERISKPV"
     gene            complement(10001..11104)
                     /locus_tag="HUW46_RS39630"
                     /old_locus_tag="HUW46_07882"
     CDS             complement(10001..11104)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010310672.1"
                     /locus_tag="HUW46_RS39630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07882"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_215543814.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 8.6e-54, bitscore:
                     182.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDVLVAGAGPAGWSVAAACAREGLHTALVDPAPSRPWTATYALW
                     RDELPSLPDSAIAAAPATTVAFGRTRHVLDREYLVLDNTGLRHWVTDERVELRQGKLDS
                     TVHGGHGSTAVLADGSRVAAAIVVDARGSRRRAGARTEQTAYGVTLSTAEAAAVTGGAT
                     ALFMDWRNSPTFLYSVPLGHDRVLVEETSLARKPGLPLGVLADRLRARLARAGVTEPRR
                     RERVRIALDTPPSLRGSTLGFGAAGGFVHPATGYSVATSLALAPAVAAALADGLPAGPS
                     RALRAARHAVWPASALAVHQLRRKGLHAVRSMPDDALPAFFDLFFALPTELHRAYTSGR
                     TDISGTASAMAHLFRTAPWRLRTRLAL"
     misc_feature    complement(10022..10024)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11182..12735
                     /gene="dgt"
                     /locus_tag="HUW46_RS39635"
                     /old_locus_tag="HUW46_07883"
     CDS             11182..12735
                     /GO_function="GO:0008832 - dGTPase activity [Evidence IEA]"
                     /GO_process="GO:0015949 - nucleobase-containing small
                     molecule interconversion [Evidence IEA]"
                     /codon_start=1
                     /gene="dgt"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637142.1"
                     /locus_tag="HUW46_RS39635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07883"
                     /product="dNTP triphosphohydrolase"
                     /protein_id="WP_215550397.1"
                     /transl_table=11
                     /translation="MDEPDPRAARRDSAAGTADLAVSPFRADRDRIVSSPFFARLGGVT
                     QVVSAGGSGLLHNRLTHSLKVATVARSIAERLLASPDAAELARKLGGLDPDVAEAAALA
                     HDLGHPPFGHLGEGVLDRVARHRFNLADGFEGNAQTFRILTTTDVRGPSAVGLDLTAAV
                     RASVLKYPWSRLHRPRPHPSEMPVPPRGAAEPGDAPGTGSSKFCAYSTEWDDFEQARAP
                     FAGRVEPWQQTVEASVMDTADDIAYAIHDLQDFHRIGVLQHAEVAAELGGWTANALELA
                     GLDAETLDSQARRPGRSLERLRRRLHAKDSWIVDDDAFALAVARVRSELVDDLLSGAFD
                     GSIEAEQALAAFSARWTARLVDGVLLTPSPPTRTGHLTLRTAQWHEVQVLKFVHRRFVL
                     LRPDLALHQRGQASLVSTLVDALDAWLVDRDEAYRLPRRLRDLVELARTEYAGIARAEP
                     ELLVGATGEPVRGTDAVYELARGRAVIDFVSSLTDKQAVSLLDALSGRASQPWSESFVL
                     "
     misc_feature    12764..12778
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.33"
                     /tool="antismash"
     gene            12934..15756
                     /locus_tag="HUW46_RS39640"
                     /old_locus_tag="HUW46_07884"
     CDS             12934..15756
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224726.1"
                     /locus_tag="HUW46_RS39640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07884"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_215543815.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.4e-15, bitscore:
                     56.5, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAAGAAGLAAALGLAVPATAGAAAGTGPAGIPATTAAQIAALQA
                     LKKTESKAESKVDSKLLVERKLRAGRTAVAVPALRTGVTVSRGGTVLVDVRAEKVGDEL
                     LAALGAAGGAVRATSVREASVRVELPLDRISALAERGDVRRIEVADRAMTARELEAPTA
                     PDRAANTNAPTAAKESKEDKAARIGAELKGAVAAATITSEGDRAHNADTARQQFGVTGI
                     GTKVCALSDGVDSLAASKAKGELPADVDVPAGQEGDGDEGTAMLEILHDVAPGAKLGFA
                     TAFTSDASFADNIRTLRFKSHCDVLVDDVIYFKESPFQDWMIAQAVNDVTADGALYFSS
                     AGNEGSVRDGTAAHWEGDFVDSGLTAGKFQGSAHNFAGTAGVQIYEPVSKASSAGIPVN
                     LFWSDPLGASANDYDLYLFDQAGNVVSLSQDNQTGTQDPYERLDTPAGGGSGLRIAVVK
                     YSGENRYLSLSALRGRFSDSTDGLKAYNTPGMTFGHSAARQAFSVAATPAAKAFGRPLE
                     PGDPANPAGPFPGTFSEASKVERFSSDGPRRVFYEANGTPITPGNVSSTGGEVRAKPDV
                     TAADGVRTSVRGFDPFFGTSAAAPHAAAIAALVLSGNPGIRGSEVRDALISTAVDIETP
                     GRDEVSGAGVLLADRVLAYTGASPQPLAVARQPIVTSGGGHLRPGDTATVALPVVNDGD
                     GTAVSTNVVLTSPTSGVTIAPRAKSYGTISPHQTGINEFTVTVPGSQQLGSTVVLAARV
                     TFAGSLSPTTQQFALSVGQPSPETRTFAYTGPPVPIPDSNPAGAGVPIQVSGVGRAAKL
                     TVSIDGTACTTDVGATTVGIDHSYVNDLTATLTAPDGSKAILLQRNGGSGNNLCKVVFA
                     DDTANAFSTVTAANAPYTGTWRPQNPLSALRANAVDGTWTLSVIDGVAGDSGSIRAVSL
                     HVNGFLQQES"
     gene            15821..16474
                     /locus_tag="HUW46_RS39645"
                     /old_locus_tag="HUW46_07885"
     CDS             15821..16474
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680685.1"
                     /locus_tag="HUW46_RS39645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07885"
                     /product="acVLRF1 family peptidyl-tRNA hydrolase"
                     /protein_id="WP_215543816.1"
                     /transl_table=11
                     /translation="MNRTRRVAGGGRAVEVAPERLGGWFARFADRNGGIAHTRPGADEV
                     VVTAGNGATATVTVPFPPLDAPGDLDALIAHANAPRRIGLLLVRLGGHSVGVAEGGRVV
                     VSRTAGRLVHGRSAAGGWSQQRFARRRDAQARQAVRAAASDAADVLGTRLPELDAVVLG
                     GDRAALDEVRRDRRLSGVFALALPRVLDVAEPRRSVLDEAAKRALAVEVVVRDA"
     gene            16488..17495
                     /locus_tag="HUW46_RS39650"
                     /old_locus_tag="HUW46_07886"
     CDS             16488..17495
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1286: Pentapeptide
                     repeat protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024986.4"
                     /locus_tag="HUW46_RS39650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07886"
                     /product="pentapeptide repeat-containing protein"
                     /protein_id="WP_215543817.1"
                     /transl_table=11
                     /translation="MTRSTFWRLVAGGIVFVALAIVCLTLAPGWFHPSLTDADLRGVGS
                     AETRIGLQQAQAQLQNNVRGTVLQAIAGVLVVAGAAATWRQVHVNREGQLTERFTRAVD
                     HVGSENRDVRIGGLYALERVARNSPADRDTIQFLLATFVRTHAPWAVGAPDGPEHPTPT
                     VDESVSWLQVRAPDIQAALDILGRVPCSKNRPRLYLSRVDLRSLQLHNARLVDTQLRHA
                     NLARAWLRGVRMDSSDLKGTDLRRANLEGAVFRNANLGGVQFAGARVRGVDFREADLTG
                     ADLGGADVCGADFRGANLTGTAFAGAFADGATRWPDGFDTGRLTRPAGEKPHAR"
     misc_feature    17603..17618
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.88"
                     /tool="antismash"
     gene            17637..19265
                     /locus_tag="HUW46_RS39655"
                     /old_locus_tag="HUW46_07887"
     CDS             17637..19265
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645324.1"
                     /locus_tag="HUW46_RS39655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07887"
                     /product="ABC-F family ATP-binding cassette
                     domain-containing protein"
                     /protein_id="WP_215543818.1"
                     /transl_table=11
                     /translation="MITATGLELRAGSRILLSGTTLRIQQGDRIGLVGRNGAGKTTSLK
                     VLAGEGEPYSGEVKQTGELGYLPQDPREGDLSVTAKDRVLSARGLDTLLRDMEKQQMAM
                     AELADDDARDKAIRRYSRLEERFASLGGYAAESEAARICSNLGLADRVLAQTLQTLSGG
                     QRRRVELARILFAAAEAGAGGKSETILLLDEPTNHLDADSISWLRGFLKAHEGGLVVIS
                     HDVDLLADVVNKVWFLDATRGELDHYNMTWQRYLDARATDEKRRRRERANAEKKASALQ
                     QQAAKLGAKATKAVAAKNMARRAEQMLANLDDTRQADRVARIKFPEPAPCGRTPLTAEG
                     LSKSYGSLEIFTGVDLAIDRGSKVVVLGLNGAGKTTLLRLLGGMEKADTGSMVPGHGLR
                     LGYYAQEHETLDHDASVWENIRHLAPDTGAQELRNLLGSFLFTGEQLDQPAGTLSGGEK
                     TRLALAGLVSSAANVLLLDEPTNNLDPASRAQVLDALRSFTGAVVLVTHDPGAVEALEP
                     ERVILLPDGTEDHWSADYLELVQLA"
     misc_feature    19292..19305
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     misc_feature    complement(19298..19313)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.24"
                     /tool="antismash"
     gene            19314..19655
                     /locus_tag="HUW46_RS48845"
     CDS             19314..19655
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019812435.1"
                     /locus_tag="HUW46_RS48845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_256451400.1"
                     /transl_table=11
                     /translation="MAQHDRSFVSFFAPRLAFRRAVFDHCGSRGRKWPRTLSGGRRTDV
                     ADLKKGARITGNTRDKLAADLKKKYEKGASIRSLAESTGRSYGFVHRVLSESGVQLRGR
                     GGATRVKKK"
     misc_feature    19336..19351
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.96"
                     /tool="antismash"
     misc_feature    complement(19338..19349)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.45"
                     /tool="antismash"
     gene            complement(19642..20940)
                     /locus_tag="HUW46_RS39665"
                     /old_locus_tag="HUW46_07889"
     CDS             complement(19642..20940)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224729.1"
                     /locus_tag="HUW46_RS39665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_07889"
                     /product="glycosyltransferase 87 family protein"
                     /protein_id="WP_254125396.1"
                     /transl_table=11
                     /translation="MTGETTLDETRRPARFRPPPRTLDAAFFLFAFGYALITALTNEFY
                     GFRVWGNFAAAGYGLGLVLTIAELVAARRGLVLPRLLASRWTPIALAAVLAMLVPLAVL
                     VVRRLTGVDWLITPWSWAAQPEVWVIERSASLLLDHGTPYVDVLSLDRPPEVNDYTPYG
                     PVMTVFGLPRALFGGTPVTDALTDARLMFALCVCLCLWGTWRLLGRPRITVAAAQLTAV
                     FPLTALIWSTSGPDLAIFGLFVLALALAAARRPVLAGVLAGAVVSAKLIVASAVVVLAV
                     FVFARLGSRAFGRFAATAIGLCVVLNLPVFLADPGAFVEHVIRFPTGSGVVVSPAGSPF
                     PGYLIAGLGTAGKIAAFALLGMAALAIGAWVLLRPPATGSDAVLRIVVGLCAQTMLAPA
                     TRFGYLVYPIALLGVLLVFREHERAKPSAVTSS"
ORIGIN
        1 cccccaagct gcgccactgg gtcaaggagg tcaaggagga gatgggcaag ctcgacatct
       61 cgtccgagtt cgccgagcgc agcgtcaacg aaggcttctc cggtggtgag aagaagcgcc
      121 acgagatcct ccagctttcg ctgctgaagc cgaagatcgc catcctcgac gagaccgact
      181 ccggcctcga cgtcgacgcg ctgcgcgtgg tgtcggaggg cgtgaacgag tacaagtcga
      241 acaacgaggt cggcgtcatg ctgatcacgc actacacccg gatcctgcgt cacatcacgc
      301 cggacttcgt gcacgtgttc gcgggcggca agatcgtcga gtccggtggc aaggagctcg
      361 ccgacgagct ggaagaaaac ggctacgtga agtacgtcgg caaggccgag cccgccaccg
      421 cctgacgttc agtccacttc ggagagtccg aacgcaccga gagaggggtt ggcccagtga
      481 ccaccaccac tgctaactct ctgccgatcg aggtcgacgc gatccgcgcc gacttcccca
      541 tcctgtcccg taccgtccgg gacgggaaac ccttggtgta cctggactcc ggcgccacct
      601 cgcagcggcc gacccaggtg ctggacgcgg agcgccggtt cctggagacg tccaacgcgg
      661 ccgtgcaccg gggcgcgcac cagctcgcgg aagaggccac cgacgcctac gagtacgccc
      721 gcgcgcgtac cgcggagttc gtcggggtct ccccgcagga gctggtgttc accaagaacg
      781 ccaccgaggg catcaacctg gtcgccttcg cgatgagcaa cgccgccacc gcggggcccg
      841 agtcggagcg cttccgggtc gggccgggtg acgagatcgt cgtcaccgag atggagcacc
      901 acgcgaacct ggtgccgtgg cagcagttgt gccagcgcac gggtgcgacg ctgcgctggt
      961 tcggcgtcac cgcggacggc aggctcgatc tgtccaccgt ggacgaactg atcaccgagc
     1021 ggacgaaggt gctcgcgttc acgcaccagt ccaatgtgct cggcaccgtg aacccggtga
     1081 agctgctgac cgagaaggcg aagaaggtcg gcgcgctgac cgtgctcgac gcctgccagt
     1141 cggtgccgca ctcgccggtg gacttcgccg atctcggtgt cgacttcgcg gtgttctccg
     1201 cgcacaagat gctcgcgccg tccgggatcg gtgtccttta tggacgccgt gaactgctcg
     1261 aagcgatgcc gccgttcctg accggtggtt cgatgatcga gctggtcaag atggagggca
     1321 ccacgttcgc gccgccgccg cagcggttcg aggccggttc gccgatgacc tcgcaggcgg
     1381 tcgggctcgg tgccgcggtc gactacctct cggtggtcgg catggagcgc gtcgccgcgc
     1441 acgaacacgt tctgaccgag gcggcgctgg ccgggctcgg cgggatcgac ggcgtgcgga
     1501 tcatcgggcc gaccgacacg gtcgaccgcg gtggcgcggt gtcgttcgtg atcgacgggg
     1561 tgcacccgca cgacgcgggc caggtgctcg acagcctcgg catcgcggtg cgcgtcgggc
     1621 accactgcgc gtggccgctg caccggagct gctcggtccc ggcgaccgtg cgcgcgtcgt
     1681 tctacctcta caacacgctg tccgaagtgg acgctctggt gtccggggtg cgcgaggcgc
     1741 agaagttctt cggagtggtg tgagcgatga acctggagag catgtaccag gagatcatcc
     1801 tggaccacta caagaacccg cacggccgcg gcctgcgcga tcccttcgac gccgagtcgt
     1861 tccaggtcaa cccgacctgc ggcgacgagg tgacgctgcg cgtgaagatc gacggggaca
     1921 aggtcgccga cgtctcctac gagggccagg gctgctcgat cagccaggcg tcgacgtcgg
     1981 tgctgacgga tctggtggtc ggcaggacgg tggacgaggc gttcggcacg atggacgcgt
     2041 tcgtcgaact gatgcagggc aggggacagg tcgagccgga cgaggaggtg ctggaggacg
     2101 ggatcgcgtt cgccggcgtc gccaagtacc ccgcccgcgt gaagtgcgcg ctgctcggct
     2161 ggatggcgtt caaggccgcg gtggcggatt ctggggtggc ggccaccacc acgaccccga
     2221 aagagtgaag gatcatgact gacgagactc agacgaccga ggtgcccgaa caccgcgagg
     2281 gtcggaccgc cgcggacctg ccggagcagc aggcgaaccc gggtgccgac gtggcgaaga
     2341 tcgaggacct cgaagaggcc atgcgcgacg tggtggaccc cgagctgggg atcaacgtcg
     2401 tcgatctcgg cctggtgtac gacatccacg tcgacgacga caacaccgcc accatcgaca
     2461 tgaccctgac ctcggcggcc tgcccgctga ccgacgtgat cgaggaccag acggcctcgg
     2521 tgctggtcgg cagcgcgggc ctggtgaagg acttccggat caactgggtc tggatgccgc
     2581 cgtggggccc cgagaagatc accgaggacg gccgcgagca gctgcgcgcg ctcggcttca
     2641 ccgtctgaac cgcctcgaag gaagcgcccc ggcccgcgcc ggggcgcttt ctcgttcgat
     2701 cggtgtataa cgacctatac ggcaccgctc tggggcggtc gttccggtcg tggcaagatg
     2761 aacgacacgg gccgaggggc cggtccgtcc acaaaggacg taacgtccgc gacaaggtga
     2821 cgatggggcg accgtgaccg aatcgaactt cccgccacct ccgcgacgcc gcttttcccg
     2881 tcgcctcgcg ctggcgctcg tactggccgt cgccgggctc gtggtcggga tcgtcggcgt
     2941 ggtcaaggtc ctcggctacg agacgttcga ctacgaccgg accaccatgg cggcgaccat
     3001 gcccgccagc ggcaaggcga tcgtctcacc ggtgccgccg agcgcgctgc accgcgggga
     3061 catcgtcgtc ttcgacctgt cggcctaccc tggtggcaag gcgagcggcc cgacgatgaa
     3121 acgagtcatc ggcgtcggtg gcgacaccgt ggcgtgctgc gaggcgggca cgcggctcac
     3181 gatcaacggc aaggcggtca ccgaggacta cgtgcggccc gccggttacg ccgatcagtc
     3241 gttctcggtg aaggtcccgg agggcaccgt tttcgtcgcg ggggaccagc gcgacagctc
     3301 ggacgactcg cggacgtacg cgacggcggc gagcagtggc gggatcccgc tcggcaagat
     3361 cagcggtgtc gtggtgggca ccggcagcat cttctccgcg caggcgctgg acccgacgaa
     3421 ggcgttcacc gcggccgggc ttcccggtac gccggtgcgc gacaccgggt accgcaccgg
     3481 gagctggttc atgatcggcg gcctcgcggt gttcgtcgtg gcgctcatcg ccgcgctcgt
     3541 tgtgcgctcc agcggaagac gacgaacagc aggcgaagac ccaccagcgc gctgatcacc
     3601 agcaggttgt agccgaacac ctggttgagc gtcaggtcgt cggcgacgcg cggtccgccg
     3661 gtgctggcca gcagcagcac ggccatcacg ccagtggccg cgccgacgaa cgcgagcagc
     3721 atctcgtgca ccagcccggt gaccacgtcg cggtcgcgtt cgtcggcgaa caggcggacg
     3781 ttgaccgaca gcctgccctg ttcgagggcg ccggtgatcc ggtcgatgcg gcgagggatc
     3841 cggcgcagca cgggaagcag gctcagcaac tcctcggtcg cggtgtcccg cagggtttcc
     3901 gggcgcatgc gggcgccgat ctgcgcgtcg gcgaaggcac gggactccac gacgatgttg
     3961 aacccgggcg cgagcagcgc cagcgtgcct tccacggtgg cgagcgcgcg gaagacggcc
     4021 gcgatggcgg gcgggatggc gagcccgaac tcggcgacga tccggaagag gtccgtgaac
     4081 atctccacgt cgggtgcctc tccgtgactg aagtgcttgg ccaccaaggc gcccagcgcg
     4141 cgttcgagcc gttgttcgtc gatgtcgtcc ggccggtcca cgatttcgag cagcccgtcg
     4201 cgcagcgctg ccgggtccgc gcggtcgatc gcgagcatca gctgctgcaa cccgccgcgc
     4261 agcccggaat cgagcctgcc gaccgagccg aagtcgagga ggccgagctt tccgttcgcg
     4321 agcagcagca cgttccccgg gtgcgggtcg gcgtggaaga cgccgtgcag catcacctgg
     4381 cgcagcaggc agtcgagcag tgcgcgagcc aagggtgccc ggtcgccgtc cgggatccgg
     4441 ccgccggagg agccgagcgg ggtgccgtcg agccggtcca tcaccagcac cttgtccgtc
     4501 gacagtcgcg aatggactct cggcaacgcg atggcgtctc cggtgtaggc cgcccgcacg
     4561 gcgccgagat tgcgggcctc cacccggaag tcgagctcct cggccagcgc ttcggcgaac
     4621 ccctcggcga gatcgacgac gccgagcgcc cgcgcccatt tcgcccgtcg ctgcaacgat
     4681 tccgcgacgc ggcggacgat gtcgagatcg cggtcgacct tcttctcgat cccgggccgc
     4741 tgcaccttga cgacgacgtc ggtgccggac ttgagccgcg cgcggtagac ctgcgcgatg
     4801 gaggcggccg cgatcggctc ccgatcgaat tcggcgaaga tctcgtcggg tgccgcgccc
     4861 agttcctcgc gcaggaggcg ttcgatctcg tcgaccggcg cgtgcgcgac ctggtcctgc
     4921 agcttgctga gctcgtcgat gaacaccggt ggcagcacgt cgggccgggt cgagagcacc
     4981 tgcccgagct tgacgaaggt tactccgcct tcttcgagcg ctttgcgcag tgaacgagcg
     5041 agcttggcgt gccgcacgtc gccggtggcg cgccgcccgg tgaggtacgg gccgaggccg
     5101 tgcctcaccg cgatgcgggt gatctgcgaa taccggcggg cgcgggagaa ccggcccttg
     5161 accgcccgca gcctgccgag caggccgagg ccaccgccgc tcgggaccgc catttccgcc
     5221 acgaacagga acagcagcgt ggtgaggaag gcgcatcccg cgatcgggat cagcagaccg
     5281 gcgaacgtct cgcgtgacca cgcgccccgc acggagtaca gcaccgatcc cgccaccgcc
     5341 cacccgaacc cggcgccgac gagggtgcgg agcgtgccga tccggacgcc gagcacgcgg
     5401 cgcgaggcga ccacgagcgg ccacagcatc agcacgaaga acggcaggct cagcaggccg
     5461 tacaggagag aggtcatcac gttccgaacg gtcgacgcgg atatcggaac ggatcaaacc
     5521 acggtgggcg cggcgacggg tcgtactcgc gggtgtcctt cctcccgcta aggagtgaac
     5581 gggattcggt gaaaccactt cctacttttg gccgtggttg gcaactttcc gaccccttag
     5641 cgtgactctc cgcagcagaa cgacttccag ccggaaaggc agacggcatg agtgcttcaa
     5701 cgggcaggcg ggcggcggcg ggcttggtga tcgcgggtgc ggcactggcg gcgcagctgc
     5761 tcggtggcgg gcctgcgaac gcggcgccga cggtgaccac cctgcactac gactcctccg
     5821 gcgcgccgga ctacgtcgcg cagatcgacc agggtgcgga gaactggaac aacgccgtga
     5881 agaacgtgaa gctcgaaaag ggcggctcgg cgacgatcat catccacgaa acccacgacg
     5941 gcaagggctc ctacacccag accgacgggc acggccacgg cgacatctac atcgactcga
     6001 cccaggtcga cgagggcaac gacccgacga ggatcgcggc gcacgagatc gggcacaacc
     6061 tcgggctccc cgaccactac gagggcccgt gctcggagct gatgtcgggg cacggccccg
     6121 gcacttcgtg caagaacgcg aagccggacg cgaacgagtc ggccaaggtc gacgagaact
     6181 tcgcgaacgg gctcgccacg gtggtgaaga cgttccggga ctgattcccc ggtggtggcg
     6241 cctccctccc gcgcgggagg gaggcgcttc gctgccggag tctgcgacga ttccggcatg
     6301 gcgttgcgac gggtgctggg cccggtggtg agccggtcca cctaccgcgg gtggatctac
     6361 ctcgtcgtgg gcggcgcgat gctggtgccg tacctgctgc tggtcgcggt cgtggtgccg
     6421 atggtgctcc cggtggtgct ggaggtgccg aaggcgttcg tggtcagctg cgtgctggcg
     6481 ctgctcgtgc tcgccggcac gaccctgctc tccccggtgc gggtgctgga aggcaccgcg
     6541 gtgcgcgaac tgctcggtga cccggtgccc gacgcggtgt tcgggccggt gcacgactgg
     6601 cggcagcggt ggcgcagcgg tgcgatggtc gtggtgcacg tgctcgtcgg cggggtgctg
     6661 agcacgatca gcctgctggt gccgatcgcg gtgggtcttt cgatcgcggg gccgttcacc
     6721 ggcaggctcg cgctcggcag tgaccagtcc gcgctcgagg tcccgaaggg ctgggcgggg
     6781 atctgggtgc cgttggtcgc tctgctgggc gcgctggtct tcctgtacgt cgtcgcggga
     6841 tcggtccggt tgctggcgat gacggcgacg cggctgctgg acgtgtcgcc gagcgagcgg
     6901 atcgcccagc tcgaacggcg caccgaacgg ctggcggagc gcaatcggct cgcgcgggaa
     6961 ctgcacgatt ccgtcgggca cgcgctgagc gtcgtcacca tccaggcggg cgcggcgagg
     7021 cggacgttgc gccgcgaccc cgatttcacc gagcgcgcgc tgaccgcgat cgaagactcg
     7081 gcgcgcgcgg ccctcgatga tctcgaccac gtgctggggc tgctgcgcga ggaaacgtcg
     7141 gggaaggcgc cgcaggcgag cctcggcgag ctgcccgcgc tgctttcggc gacccgtctc
     7201 gccggcgtcg aggtcgagtc cgaggtgacc ggcgagctcg ccgcactgcc acccgtggtg
     7261 tcccgcgagg cgtaccggat cgtgcaggaa tgcctcacga acgtggtgcg ccacgccggt
     7321 aaggtgccgg tgacgctgcg cgtcgcggtc ggcgagtcgc gtttggactt gctggtccgc
     7381 aatccgctgg ggcagcaggc gcccgcggaa cggcgtggcg gcggaagggg actgcggggc
     7441 atggcggaac gggtcgacgt gttgcgcggc gaactgcacg ccgggcgtgc gggagaacac
     7501 tgggaggtcg gcgtgaaact gccgtggggc gcggtatgac cggggtgctg ctcgtcgacg
     7561 acgaggaact gatcagggcg ggcctgcgcg cgatcctcga ctccgagccg gatatcgagg
     7621 tgctcgggga ggccggtgac ggtgccgagg tggcgggcat ggtcgcgcgg ctgcgtccgg
     7681 acgtggtgct gatggacgtc cggatgccca aagtggacgg catccgcgcg acaacgcact
     7741 tgttgtccac aatggacgag ccgccgaagg tcgtcgtggt gaccacgttc gagaacgacg
     7801 actacgtcta cgacgcgctg ctggccggtg cgagcgggtt cctgctcaag cgcgcgcggc
     7861 cggaggagat cgtcaccgcg gtccgcaccg tggtgacggg ggagtccttg ctgttccccg
     7921 cggccatccg cagactggcc gaggcgcacc ggccgcggga gaagggccgt gacgcgctgg
     7981 cgaaggcgtc gctgaccgag cgggagtccg aagtgctcac gctgatggcc gccggactgt
     8041 ccaatgtgga gatagcgggg aagctgttcc tcggcgtgca gacggtgaag acgcacgtgg
     8101 gcaacgtgct cgcgaagctc ggcgcgcggg acaggacgca ggcggtgatc agggcctacg
     8161 agtcggggtt catcacaccg gcttgctgat ccgctcgtcg cgcggcacgg gcagcgcggt
     8221 gcgggtgcgc gtcagcccgc gcagcacgtc gatgcgatcg gagtccggcc tgccgagcac
     8281 ccagctcgac ccggcgacgg ccttcgcgcg cttcttgagc ggggcgagca tgcgggacgc
     8341 ctcgcggtag gtgctgatcg tcgcggtcga acacaccagc gtggccagcg agaccgtcac
     8401 cgccatgcct tcggcgctcc acggggtgtc gagcagcgcg gaggccaccg tgctgatttc
     8461 gtcgacgtcg caggcgatga ggaagtcgtc gccgccgacg tggctcaccg tcatcttcga
     8521 cagccgcgcc tccagatcgg tgagggtgcg gccgagcgcg cggatgaggt cgtcgcccgc
     8581 ggcgaacccg gcgttgtcgt tgacggattt gaacgagtcg acgtcgagcc acgcggccac
     8641 gaacggttcg cggcaggcga tgcggcggtc gacgtcgcgc gccaccgttt cgctgccggg
     8701 gagccgggtg agcgggctga gcgcggcggc ggcctcgacc ttcgcctccg cgacaccgcg
     8761 taccacctcg gtcaccagca cgacgccgag gcagcggccg tcgtcgtcga ccacgacgac
     8821 gtcgtcaccg gtgcggctcc agtcggcgtc ggtgaccagt tcgaggaatt cgagcgcgcc
     8881 tgcttcagtg tggatcgtgt gcgggctgtc cgcgagccgg tcggccgagc gcttggcgtg
     8941 cagcgcgtgg ccgtagggcc cggtgacggc gagcaggaac ctggtccggt cgatcgacca
     9001 ctgcgggcgg ttgtcgtcgt cgaccccgac gatgccggac ggcccgtcgt ccgcggccag
     9061 cacggtgcgg acgtcctcgc aggtggccgt gtgcggcagg gtgctcgcct ggcggaggaa
     9121 gtcgccgacg cgcttcgagg gcacggcgcc gccgccggtg gtgcggtgct ggccgggctc
     9181 cagcgtggcc gcggtgcgga ccccgatcca ctgggtgtcc tcgcccgcgg caccgaacag
     9241 gtttccttgc gcgatccgga ctccgagctc gcggacgatg tcgagctggg cgtcggtctc
     9301 gacgccggtc gccacgagcc gcgcctgcgc gcgcgaggcg tagtgcagca gcgcttcgac
     9361 cacggcgatc gcccccggtt cgcccggcag gcgctggagg aggctgcggt cgagcttgag
     9421 cacgtcgacc ggcgcggtgg cgagcagggt gagcgggagg tcgctgcggc cgagcccgtc
     9481 gagcgcgagc cggaagccga ggtcgcccag tcgcttcatc ccggagagca gctgctccgg
     9541 ccacgtggtg gtgaacggcg ggccgagttc gagcaccacc tcgcgcggcc tgcggccgac
     9601 cttggcgagt gcgtcgagga gcgggtcgag cgcgctctcc ggcgcggccg cggtcgccgc
     9661 ggtgaggttg aggtgcaggg gcagcagcgt ctgctgctcg gcctcgtagc gcacggcgcc
     9721 cgcggcgagc gcgacgtcga cttccacgag acgtcgttct ctgcgcgcgt ggtcgagcag
     9781 ctcgttcgct gaccccttgc tcggccgtgc cagcgcttcg agcgcgacga caccgccggt
     9841 gtgcaagctg tacaacggct ggaaggcgaa ccggacactc ggcgagacag ccacgcacag
     9901 atagtcgccg cagtacccgg aatccgatac ggatgtcgtc tactgttcat cgcgatggca
     9961 ccggggttag ccgtatcggt gtaatcccga ggccggattc tcacagagcg agacgagtgc
    10021 gtaaccgcca tggcgcagtc ctgaacaggt gtgccatcgc cgaggcggtg cctgagatgt
    10081 ccgttcttcc cgatgtgtag gcgcggtgca gctcggtcgg gagcgcgaag aagaggtcga
    10141 agaacgcggg cagcgcgtcg tcgggcatcg accgcaccgc gtgcaggccc ttccggcgca
    10201 gttggtggac ggcgagcgcg gacgcgggcc agaccgcgtg gcgggcggcg cgcagtgccc
    10261 ggctggggcc ggcgggcagc ccgtcggcga gtgcggcggc gaccgccggc gcgagtgcga
    10321 gcgaggtggc gacgctgtac ccggtcgcgg ggtgcacgaa tccgcccgcc gcgccgaagc
    10381 cgagcgtgct gccgcgtagt gacggcgggg tgtcgagtgc gattcgcacg cgttcgcgtc
    10441 ggcgcggttc ggtgacgccc gcgcgggcga gccgggcgcg gagccggtcc gcgagcacgc
    10501 cgaggggcag gccgggtttg cgggccagcg aggtctcttc caccagtacg cgatcgtgtc
    10561 cgagcgggac ggagtacagg aacgtggggg agttccgcca gtccatgaac agcgcggtgg
    10621 cgccgccggt caccgcggcc gcttccgcgg tggaaagcgt taccccgtaa gcggtttgct
    10681 cggtgcgcgc gcctgcgcgc cggcggctgc cgcgcgcgtc gaccacgatc gccgcggcca
    10741 cgcgggatcc gtcggccagt acggcggtgc ttccgtgtcc accgtggaca gtcgagtcga
    10801 gcttgccctg ccgcagttcc acccgttcgt cggtgaccca gtgccgcaga ccggtgttgt
    10861 ccagcaccag gtattcgcga tcgagcacgt gcctcgtccg tccgaacgcg acagtggtgg
    10921 ccggtgccgc cgcgatcgcc gagtccggca gcgagggcag ttcgtctcgc cacagcgcgt
    10981 aggtcgcggt ccacggccgc gacggcgccg ggtcgacgag cgcggtgtgc aggccttcgc
    11041 gcgcgcacgc cgcggccacc gaccagcccg cgggacccgc gcccgccacg aggacatcca
    11101 ccacggcacc gatcacacca caggtccggt gtggccggac ggtggtggcc gcgtttggtt
    11161 acggtggtgc gcatgcgagg aatggacgag ccggacccga gggcggcacg acgggacagc
    11221 gcggccggta ccgcggacct ggcggtgagc ccgttccgcg cggatcggga ccggatcgtc
    11281 agctcgccgt tcttcgccag gctcggcggg gtcacgcagg tggtcagcgc gggcgggtcc
    11341 gggttgctgc acaaccggct cacgcacagc ctcaaggtcg cgaccgtggc ccggtcgatc
    11401 gccgaacggc tgctcgcctc gcccgatgcc gccgaactgg cgcgcaagct cggcgggctc
    11461 gatcccgatg tcgccgaggc ggcggccctc gcgcacgatc tcggccaccc gccgttcggg
    11521 cacctcggcg aaggcgtgct cgatcgcgtg gcgcgccacc ggttcaacct cgccgacggg
    11581 ttcgagggca acgcgcagac cttccggatc ctgaccacca ccgacgtgcg gggcccgtcc
    11641 gcggtggggc tcgatctcac cgcggccgtg cgcgcctcgg tgctgaagta cccgtggtcc
    11701 cggctgcacc ggccgcggcc gcatccgtcg gagatgcccg ttccgccgcg cggggcggcc
    11761 gagccgggcg acgcgccggg caccgggtcg agcaagttct gcgcctacag caccgaatgg
    11821 gacgatttcg agcaggcgag ggcgccgttc gccggccgcg tcgaaccgtg gcagcagacc
    11881 gtggaagcgt ccgtgatgga caccgccgac gacatcgcct acgcgatcca cgacctgcag
    11941 gacttccacc ggatcggggt gctgcagcac gccgaggtcg ccgccgagct cggcggctgg
    12001 acggcgaacg cgctcgaact ggccgggctc gacgcggaga cgctcgattc gcaggcccgc
    12061 cgtcccggcc ggtcgctcga acggctgcgg cggcgcttgc acgccaagga ttcgtggatc
    12121 gtcgacgacg acgcgttcgc cctcgcggtg gccagggtgc gcagcgaact ggtcgacgac
    12181 ctgctttccg gcgcgttcga cgggtcgatc gaggccgagc aggcgctcgc ggcgttttcc
    12241 gcccgctgga ccgcgcggct ggtcgacggc gtgctgctga ccccgtcacc gccgaccagg
    12301 acggggcacc tgacgctgcg caccgcgcag tggcacgagg tacaggtgct gaagttcgtg
    12361 catcggcggt tcgtcctgct gcgccccgat ctcgcgttgc accagcgcgg gcaggcgagc
    12421 ctggtgtcca ccctcgtcga cgcgctggac gcgtggctcg tcgatcgcga cgaggcgtac
    12481 cggctgccgc ggcggctgcg cgatctcgtc gaactggcgc gaacggagta cgccgggatc
    12541 gcccgtgcgg agccggaact tctggtcggt gccaccggtg aacccgtgcg gggcaccgac
    12601 gcggtgtacg agctggcgcg cggtcgcgcg gtcatcgact tcgtgtcctc gttgacggac
    12661 aagcaggcgg tgtccctgtt ggacgccttg tccggcaggg cctcccaacc ctggtccgag
    12721 tcgttcgtcc tgtgacgaca acggagaatc gcgctctgtg atcggaaaat ccggttcgtg
    12781 catcactcga aaggctgatg taagccattg cggtgagtac ttagcttgat tcaaccggtg
    12841 atcgccggtg ctggtcagcg tgagtcgggg cacgcgccga gaaactcgga ggcgcacgtg
    12901 cgtcgagttc gttcacgaag aggcagaaga gcggtgctgg ccgcgggggc ggcgggtctc
    12961 gccgccgcac tggggctggc ggtccccgcg accgccggtg ccgcggccgg caccggtcct
    13021 gccggaatcc ccgccaccac cgcggcgcag atcgccgcgc tgcaggcgct caagaagacc
    13081 gagagcaagg ccgagtccaa agtagacagc aagctgctgg tggagcggaa gctgcgcgcc
    13141 gggcgcaccg cggtggccgt gccagcgctc cggaccgggg tcaccgtttc ccgcggtggc
    13201 accgtgctgg tcgatgtcag ggccgagaag gtcggtgacg agctgctcgc ggcgctcggt
    13261 gcggcgggcg gcgcggtgcg cgcgacctcg gtcagggaag ccagtgtgcg ggtggagctg
    13321 ccgctcgacc ggatcagcgc gctggccgaa cggggcgacg tccgccggat cgaggtggcg
    13381 gaccgggcga tgacggcgcg cgagctggaa gcgccgacgg caccggaccg ggcggcgaac
    13441 acgaacgcgc ccaccgccgc caaggagtcc aaagaggaca aagcggcgcg gatcggcgcc
    13501 gagctgaagg gcgccgtggc ggcggccacg atcaccagcg agggcgaccg cgcgcacaac
    13561 gcggacacgg cgcgccagca gttcggcgtg acgggcatcg gcaccaaggt gtgcgcgctg
    13621 tccgacggcg tcgactcgct cgccgcgtcc aaggccaagg gggaactgcc cgccgacgtc
    13681 gacgtgcctg ccggtcagga aggcgatggc gacgagggca ccgcgatgct cgaaatcctg
    13741 cacgacgtcg cgccgggcgc caagctcggc ttcgccaccg cgttcacctc ggacgcgagc
    13801 ttcgccgaca acatcaggac gctgcgcttc aagtcgcact gcgacgtgct cgtcgacgac
    13861 gtcatctact tcaaggaatc gccgttccag gactggatga tcgcgcaggc ggtcaacgac
    13921 gtcaccgcgg acggcgcgct gtacttctcc tcggctggta acgaaggcag cgtccgcgac
    13981 gggaccgcgg cgcactggga gggcgacttc gtcgactccg ggctgaccgc gggcaagttc
    14041 cagggcagcg cgcacaactt cgcggggacg gcgggagtcc agatctacga accggtctcg
    14101 aaggcttcgt cggcgggcat cccggtgaac ctgttctggt cggacccgct cggcgcgtcc
    14161 gccaacgact acgacctcta cctgttcgac caggcgggca acgtggtcag cctcagccag
    14221 gacaaccaga ccggcacgca ggacccgtac gagcggctgg acaccccggc cggcggcggg
    14281 tcgggcctgc ggatcgcggt cgtgaagtac tccggcgaaa accggtacct ttcgctttcc
    14341 gcgctgcgcg ggcggttctc cgattccacc gacgggctca aggcgtacaa cacgcccggg
    14401 atgaccttcg ggcacagcgc ggcgcggcag gcgttcagcg tcgcggccac ccccgcggcg
    14461 aaggcgttcg gcaggccgct cgaaccgggt gacccggcga acccggcggg gccgttcccc
    14521 ggcacgttca gcgaggcgtc gaaggtcgaa cggttctcgt ccgacggacc gcggcgggtg
    14581 ttctacgagg cgaacggcac gccgatcacc ccgggcaacg tgtcttccac cgggggagag
    14641 gtgcgcgcca aacccgatgt caccgcggcc gacggcgtgc gcacgagcgt gcgcgggttc
    14701 gacccgttct tcggtacctc cgcggcggct ccgcacgcgg cggccatcgc ggcgctcgtg
    14761 ctgtccggca atcccggcat ccgcggatcc gaggtgcgcg acgcgctcat ctccaccgcg
    14821 gtcgacatcg agacacccgg gcgggacgag gtgagcggag ccggggtgct cctcgccgac
    14881 cgcgtgctcg cctacaccgg tgcgagcccg cagccgctcg ccgtcgcgcg gcagccgatc
    14941 gtcacctccg gcggcggtca cctgaggccg ggcgacaccg cgacggtggc gctgccggtg
    15001 gtcaacgacg gcgacggcac cgcggtgtcc accaacgtcg tgctgaccag ccccacgtcg
    15061 ggcgtcacga tcgcaccgag ggcgaagtcg tacggcacga tcagcccgca ccagaccggg
    15121 atcaacgagt tcacggtgac ggtgcccggt tcgcagcaac tcggcagcac cgtggtgctc
    15181 gccgcgagag tgaccttcgc ggggtcgctt tcgccgacca cgcagcagtt cgcgctgagc
    15241 gtcgggcagc cgtcgccgga gacgcgcacc ttcgcctaca ccggcccgcc ggtgccgatc
    15301 ccggacagca acccggcggg cgcgggcgtc ccgatccagg tgtccggtgt cgggcgcgcg
    15361 gcgaagctga ccgtttcgat cgacgggacg gcctgcacga cggacgtggg cgcgacgaca
    15421 gtggggatcg accactcgta cgtcaacgac ctcaccgcga cgctcaccgc gccggacggc
    15481 tcgaaggcga ttctgctgca gcgcaacggc ggatcgggca acaacctgtg caaggtcgtc
    15541 ttcgccgacg acaccgcgaa cgcgttcagc acggtgaccg cggcgaacgc gccgtacacc
    15601 gggacgtggc ggccgcagaa cccgctttcg gcgttgcggg cgaacgcggt ggacggcacg
    15661 tggacccttt ccgtgatcga cggcgtcgcg ggcgattccg ggtccatccg cgcggtttcc
    15721 ttgcacgtca acggtttcct tcagcaggag agctgagccg ggcgggtgcc cgcgggtttt
    15781 cccgcgggca cccgtgccgc gcgcgacgta cggtgagccg gtgaacagga cgcgtcgggt
    15841 cgccggtggc ggccgcgcgg tcgaggtggc gccggagcgg ctcggcggct ggttcgcccg
    15901 gttcgcggac cgcaacggcg ggatcgcgca cacccggccg ggtgcggatg aagtcgtcgt
    15961 caccgccggg aacggggcca ccgcgaccgt caccgtcccg ttcccgccac tggacgctcc
    16021 cggtgacctc gacgcgctca tcgcccacgc gaacgcaccg cgtcgcatcg ggctgctcct
    16081 cgtccggctg ggcgggcaca gcgtcggtgt cgcggaaggc ggccgggtcg tggtgtcgcg
    16141 gaccgcgggg cgcctcgtgc acggcaggtc ggcggcgggc ggctggtcgc agcagcggtt
    16201 cgcgcggcga cgggacgcgc aggcgcggca ggcggtgcgc gcggccgcgt ccgacgccgc
    16261 ggacgtgctc gggacccggt tgcccgaact ggatgcggtg gtgctcggcg gtgatcgcgc
    16321 ggcactcgac gaggtacggc gggaccgccg cctcagcggg gtcttcgcgc tggcgctgcc
    16381 gcgagtgctc gatgtcgccg agccgcggcg gtcggtgctc gacgaggccg cgaagcgggc
    16441 gctggcggtg gaggtcgtcg tccgcgacgc gtgagaagat ccgcgtcgtg acccggtcga
    16501 ctttctggcg cctcgtcgcg ggcggcatcg tgttcgtggc gctcgcgatc gtctgcctca
    16561 ccctcgcgcc ggggtggttc cacccgtcgc tgaccgatgc cgatctccgc ggggtgggca
    16621 gcgcggaaac caggatcggc ctccagcagg cacaagccca gttgcagaac aacgtgcggg
    16681 gcacggtgct gcaggcgatc gcgggcgtgc tcgtcgtcgc gggcgcggcc gccacctggc
    16741 gccaggtgca cgtgaaccga gaagggcagc tcacagaacg gttcacgcgc gcggtcgacc
    16801 acgtcggcag cgagaaccgc gacgtgcgca tcggcgggtt gtacgcactg gaacgggtcg
    16861 cgcggaactc gcccgccgac cgcgacacga tccagttcct cctcgccacc ttcgtccgca
    16921 cccacgcgcc gtgggcggtc ggcgcgccgg acggtcccga gcatcccact ccgacggtgg
    16981 acgaaagcgt gtcgtggctc caggtcaggg cgccggacat ccaagcggcg ctggacatcc
    17041 tcggccgcgt gccgtgttcg aagaaccggc cgcggctcta tctgtcccga gtggacttga
    17101 ggagcctgca actgcacaac gcccgcctcg tcgacaccca gctccggcac gccaatctcg
    17161 cgcgggcgtg gctgcgcggg gtgcgcatgg actcgagcga tctgaagggg accgatctgc
    17221 gccgggcgaa cctcgaaggc gccgtgttca ggaacgccaa cctcggcggt gtccagttcg
    17281 cgggcgccag ggtgcgcggg gtcgatttcc gggaagccga tctgaccggt gcggacctcg
    17341 gcggcgccga cgtctgcggg gcggatttcc gtggtgcgaa cctgaccgga accgcgttcg
    17401 ccggtgcgtt cgcggacggg gcgacccgat ggcccgacgg gttcgacacc ggccgcctga
    17461 ccaggcccgc gggtgagaag ccccacgcga ggtaaattcg gtggaccggc gcccgtatac
    17521 ttagcgtcgt gggttttcag gagatcatga gggaatagct ccggtgccgg gtcacgcccg
    17581 gcccgtcgca gctgtcccgg cacccacccc tttttcgcag tccacaggag actcccttga
    17641 tcacggccac cggccttgag ctgcgcgctg gttcgcgcat tctgctctcc ggcaccacac
    17701 tccgcatcca gcagggcgac cgcatcggcc tcgtcggccg caacggcgct ggcaagacca
    17761 cctcgctcaa ggtgctcgcc ggcgagggcg agccctactc cggcgaggtc aagcagaccg
    17821 gtgaactcgg ctacctgccg caggaccccc gcgaaggcga cctctcggtg accgcgaagg
    17881 acagggtgct gtccgcgcgc ggtctcgaca ccttgttgcg ggacatggaa aagcagcaga
    17941 tggcgatggc cgagctcgcc gacgacgacg ccagggacaa ggcgatccgg cgctacagca
    18001 ggctcgagga gcggttcgcg tcgctcggcg ggtacgcggc cgaaagcgaa gcggcccgca
    18061 tctgctccaa tctcgggctc gccgaccggg tgctggcgca gaccctgcag acgctgtcgg
    18121 gcggccagcg ccgccgggtg gagctggcgc ggatcctgtt cgccgcggcc gaagcgggcg
    18181 cgggcggcaa gtccgagacg atcctgctgc tcgacgagcc gaccaaccac ctcgacgccg
    18241 actccatcag ctggctgcgc ggtttcctca aggcgcacga aggcggcctc gtggtgatca
    18301 gccacgacgt cgacctgctc gccgacgtgg tcaacaaggt gtggttcctg gacgcgaccc
    18361 gcggcgaact cgaccactac aacatgacct ggcagcgcta cctcgacgcg cgagccaccg
    18421 acgagaagcg ccgccgccgc gagcgcgcga atgccgagaa gaaggcgtcg gcactccagc
    18481 agcaggcggc gaagctcggc gcgaaagcca cgaaagccgt cgctgccaag aacatggcgc
    18541 gccgcgcgga gcagatgctc gcgaacctcg acgacaccag gcaggccgac cgcgtcgcgc
    18601 ggatcaagtt ccccgagccc gccccgtgtg gacggacccc gctcaccgcc gaaggactgt
    18661 cgaagtcgta cgggtcattg gaaatcttca ccggcgtgga tctcgcgatc gaccgcggtt
    18721 cgaaggtcgt cgttctcggc ctgaacggtg cgggtaaaac gaccctgttg cgattgctgg
    18781 gcggtatgga aaaggccgat accggatcaa tggtgcccgg acacggattg cgactcggct
    18841 actacgcaca ggaacacgag acgctcgatc atgacgcgag cgtgtgggag aacatccgtc
    18901 atctcgcacc ggacaccggc gcgcaggaac tgcggaacct gctcggttcg ttcctgttca
    18961 ccggcgagca gctcgaccag ccagccggca ctctctcagg cggtgagaag acgaggctcg
    19021 cgttggcggg actggtctcc agtgctgcca acgtgctgct gctcgacgag ccgacgaaca
    19081 acctcgaccc ggcgagccgc gcgcaggtgc tcgacgcgct gcgcagcttc accggcgcgg
    19141 tcgtgctcgt cacccacgat cccggcgcgg tggaggcgct ggagccggag cgcgtgatcc
    19201 tgctgccgga cggcaccgag gaccattggt ccgcggatta cttggaactc gtgcagttgg
    19261 cctaaaccac acgggcagtt ccggcgcttg gttgaccgtg aacaaacact ggaatggccc
    19321 aacatgatcg cagttttgtc agctttttcg ctcctcgtct ggcattccgg cgcgcggtgt
    19381 tcgatcattg cggcagtagg ggccggaagt ggcccaggac actctcgggc ggaaggcgga
    19441 cggacgtggc ggacctcaag aagggcgcgc ggatcaccgg taacacgcgc gacaagcttg
    19501 ccgctgactt gaagaagaaa tacgagaagg gggcgagcat tcgttcgctc gcggagtcca
    19561 ccggacgctc gtacggtttt gtgcaccgcg tgctttccga atcgggtgtg cagcttcgtg
    19621 gtcgtggcgg cgccactcgc gtcaagaaga agtaaccgcg gacggcttcg cgcgctcgtg
    19681 ctcgcggaac accagtagca cgcccagcag tgcgatcggg tagacgaggt agccgaaccg
    19741 ggtcgcgggc gcgagcatgg tttgcgcgca gaggccgacc acgatgcgca gtaccgcgtc
    19801 ggagccggtg gcgggcgggc ggagcagtac ccaggcaccg atcgcgaggg cggccatgcc
    19861 gagcagggcg aaggcggcga tcttgcccgc cgtccccagc ccggcgatca gatagccggg
    19921 gaacgggctg cccgcggggg agaccaccac accggacccg gtcgggaagc ggatcacgtg
    19981 ttcgacgaac gcgccggggt cggcgaggaa cacgggcagg ttcagcacca cgcacaggcc
    20041 gatcgccgtc gcggcgaacc ggccgaacgc ccggctgccc aggcgcgcga acacgaacac
    20101 cgcgagcacg acgacggccg aggcgacgat cagcttcgcg ctcaccaccg cgcccgcgag
    20161 cacgccggcg agtaccggcc tgcgtgccgc ggccagtgcg agcgcgagca cgaaaaggcc
    20221 gaagatcgcc aggtcggggc ccgaggtgga ccagatcagc gcggtcagcg ggaacacggc
    20281 ggtgagctgg gccgcggcca cggtgatcct cggccgtccc agcagccgcc aggtgcccca
    20341 caggcacagg cacacgcaca gcgcgaacat gagccgtgcg tcggtgagcg cgtcggtgac
    20401 cggcgtgccc ccgaacaacg ccctggggag cccgaaaacg gtcatcacgg gcccgtaggg
    20461 cgtgtagtcg ttgacctccg gcggcctgtc aagcgacagc acgtcgacgt agggcgtgcc
    20521 gtggtcgagc agcaggctcg cggagcgctc gatgacccac acctcgggct gcgccgccca
    20581 cgaccacggt gtgatgagcc agtccacccc ggtcagccgc cgcaccacga gcaccgcgag
    20641 cggcaccagc atcgcgagga cggcggcgag cgcgatcggc gtccagcgcg aggcgagcag
    20701 ccgcggcagt accaggccgc ggcgcgccgc gacgagctcg gcgatcgtca gcacgagacc
    20761 gaggccgtac cccgctgccg cgaagttgcc ccacacgcgg aagccgtaga actcgttggt
    20821 gagcgcggtg atcaacgcgt agccgaacgc gaagaggaag aacgccgcgt cgagggtccg
    20881 cggcggcggc cggaagcggg ccgggcggcg ggtttcgtcc agtgtggtct ccccggtcac
    20941 caccgaagcg taacgaccgg tggtcgcggg cttgcccgcg ctacgggaag aacttcggag
    21001 gaccgggaag aataatttcg gtccacacgt taacctggtc atatgcacgg caaagctcga
    21061 ttattatcga ggttttgcct cgaactggag gggcgaagtg gaca
//
