LOCUS       NZ_CP059997            23054 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6793352
            Orig. end                         :: 6816406
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23054
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="31"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23054
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23054
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13054](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13054)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            complement(607..957)
                     /locus_tag="HUW46_RS32380"
                     /old_locus_tag="HUW46_06430"
     CDS             complement(607..957)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644510.1"
                     /locus_tag="HUW46_RS32380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06430"
                     /product="arsenate reductase family protein"
                     /protein_id="WP_215550238.1"
                     /transl_table=11
                     /translation="MEIWHNPRCSKSRAAKKALDDSGAEYTERRYLDAPPTAAELTEVL
                     GKLGAEPWDITRTAEPVAKELGLADLPRDAANRERWIGLLADNPVLIQRPILVDGQTAV
                     VGRDEEALRRIV"
     gene            complement(975..2534)
                     /locus_tag="HUW46_RS32385"
                     /old_locus_tag="HUW46_06431"
     CDS             complement(975..2534)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666763.1"
                     /locus_tag="HUW46_RS32385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06431"
                     /product="substrate-binding domain-containing protein"
                     /protein_id="WP_215542557.1"
                     /transl_table=11
                     /translation="MADFPWELVLALVGALVPIVAFLWEFAFVGRKQLGYRIQMNATAT
                     DVGREHAGAWQQLQLENDDETPLQNPSFVLLRIENTGTTNIDTHDYASPNESKVGIRFK
                     FPGRTVAGLVVADLHKTLSTAHFSPDSGLNTRNVESPGQTEGVIELPRVPLNPGQHYKV
                     LAVLESPDGGELAHPTVDGSIKTGLGSGEIKKTESFTGIPRWIVALIVALVAIASAEPF
                     VLDQFSDKPAPLDCATGRLTVTGSTAFEPIVREAMAAYAKSCQGSGFQAEMTGSTNGLE
                     QLNNSRSPDVVAFSDGLKTEVKGQKLPELIQRPVALQLFTLVANKNTGVEDLTLAQVKD
                     VFGGRVGAWKDIGAKNDLPVRLVDRESSSGTRATLEQRVLGFSEPGENSTDCEQPKTDL
                     RGQVTRCRQGDTTAVLNAVANTPGSIGYVELGAATDRQKTKQDVVKVRIDGQQSTLDTT
                     DRGMFPFWQTEYAYTFSEPKSDSLAASFLRYLTNQVGMDIIRSHGHRPCADLQNPVRCR
                     PS"
     gene            2733..3872
                     /locus_tag="HUW46_RS32390"
                     /old_locus_tag="HUW46_06432"
     CDS             2733..3872
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003070019.1"
                     /locus_tag="HUW46_RS32390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06432"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_215542558.1"
                     /transl_table=11
                     /translation="MPQSTHVTIIGAGLAGLTLARVLHLHGIRATVHEAEPSPAARAQG
                     GMLDIHDYNGQRAVEAADLMDEFRELVLEGRQAMRFVGKDGTVVFEKADDGTGGRPEVQ
                     RGELRQLLLDSLPPGTVEWGRKVDGVRDLGDGRHEVGFTDGTTTETSLLVGADGAWSRV
                     RPLLSGAVPAYTGDTFVETWLHDADERHPVAAKTVGGGTLIAAEQDRAINAHRERGGTL
                     HTYVILTRSQEWFAAIDFTDPVVATARIAGEFDGWAPELTALITDADTAPVPRPIFALP
                     TGHRWDRRPGVTLIGDAAHLAAPDGEGANNAMLDGAELGAALAAHLGDVEAALTEFEDA
                     MSTRNATPTDGAEFVEEVFGGTLPQELSDLITGFQQQPS"
     gene            3958..4629
                     /locus_tag="HUW46_RS32395"
                     /old_locus_tag="HUW46_06433"
     CDS             3958..4629
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016335790.1"
                     /locus_tag="HUW46_RS32395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06433"
                     /product="response regulator transcription factor"
                     /protein_id="WP_215542559.1"
                     /transl_table=11
                     /translation="MTLGQVLANEVGAAVVTVAVHASDPLTGLGAASILDADARLRLLG
                     GGESASAEVIVVVEDSVDDGTFALLREIRDASRLDHPPRCVIVTDHFRSEVLMTAIECG
                     MSALLPRRTMTGEDLAQAVVAVSRGVAQLPPRLQGDLLERLDRMRRDVLEPHGLTLLGL
                     SVREREVLRLLADGHGTEEIAIRLTYSESTVKNVLHGLMRRYHFTTRAHAVAFAVRAGV
                     I"
     CDS             4714..4875
                     /gene="allorf_06798066_06798227"
                     /locus_tag="allorf_06798066_06798227"
                     /protein_id="allorf_06798066_06798227"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MDARQGGSFGWSKSRARPRRIAASDRVMAVARPVAAAKEVTCDSS
                     PLFYPPCC"
     CDS_motif       4714..4824
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MDARQGGSFGWSKSRARPRRIAASDRVMAVARPVAAA"
                     /locus_tag="allorf_06798066_06798227_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4825..4875
                     /prepeptide="core"
                     /locus_tag="allorf_06798066_06798227_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.50"
                     /molecular_weight="1735.0"
                     /monoisotopic_mass="1733.8"
                     /core_sequence="KEVTCDSSPLFYPPCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MDARQGGSFGWSKSRARPRRIAASDRVMAVARPVAAA"
                     /leader_location="[4713:4824](+)"
     gene            4872..5414
                     /locus_tag="HUW46_RS32400"
                     /old_locus_tag="HUW46_06434"
     CDS             4872..5414
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015100165.1"
                     /locus_tag="HUW46_RS32400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06434"
                     /product="superoxide dismutase"
                     /protein_id="WP_331477161.1"
                     /transl_table=11
                     /translation="MTATTGVAVAAPARSAGHGHGHHIYARGTFALYTPGANAITHDPK
                     LAPVGSKVVVSGYTNAHRTKTRLYVKGLLPDREYGSHAHSKPCGEKAADSGPHHQHVQD
                     PVQPSVDPKYANPDNEIWLDFTTDHDGTGYAESTVDWGFDGERHAQSVVIHETHTHTEP
                     GHAGMAGARLACINVGF"
     gene            complement(5467..6564)
                     /locus_tag="HUW46_RS32405"
                     /old_locus_tag="HUW46_06435"
     CDS             complement(5467..6564)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223893.1"
                     /locus_tag="HUW46_RS32405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06435"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_215542561.1"
                     /transl_table=11
                     /translation="MNSNVALTVLQGVILYPALLWKIYQLTRAPKDVARWMVTACLACF
                     AAAYPFGFLAGNVNQPNPGPIVPLLFQHFFLCGLVYTLACFFLFSALPVAEARRRALLE
                     AIPFAVAMLVMVLVAVFMPDVPPARYPLAGVLTFYLAADLYLTYGIASAYFFTRRYARG
                     AGPRLARGLRVASVGFAISAVGGSTLVAVVLVHWTGAAIPWLLVQGTVFLVFPGALLLV
                     IGLSYPGVATRLAAGRVWRQHLRTYHRLGPLWTALHEAFPEDALSRAPLNPWRDALSLR
                     GVHRRYYRRAIECRDGLVRLSPYLAHLGDDGDLAERLGEALRSHARGETVAPEAMPVAM
                     PDGDSLDDDVRELVTLSDSLRAVPA"
     gene            complement(6561..7115)
                     /locus_tag="HUW46_RS32410"
                     /old_locus_tag="HUW46_06436"
     CDS             complement(6561..7115)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643418.1"
                     /locus_tag="HUW46_RS32410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06436"
                     /product="hypothetical protein"
                     /protein_id="WP_215542562.1"
                     /transl_table=11
                     /translation="MQERKLRRRCRRLLNELGIRPPLDVLELCRKVGEQRGRPIRLIAH
                     RIPVPGPFGAWIATGKADYIVYQQDTSKAHQCHIILHELGHMLAGHVATAEDDGLVTEL
                     APSAPPPGHPREQYPDLEPESVRHALRRTSYDTDHEREAETVATIILEWASVLDRVTPE
                     SSNEATARRIETALGERLGWL"
     CDS             complement(7343..7468)
                     /gene="allorf_06800695_06800820"
                     /locus_tag="allorf_06800695_06800820"
                     /protein_id="allorf_06800695_06800820"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRGGAIGGGACRWSPKATLGAPSAAHPPLAHSTTTTRLPRK"
     CDS_motif       complement(7442..7468)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRGGAIGGG"
                     /locus_tag="allorf_06800695_06800820_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(7343..7441)
                     /prepeptide="core"
                     /locus_tag="allorf_06800695_06800820_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.60"
                     /molecular_weight="3237.7"
                     /monoisotopic_mass="3235.8"
                     /core_sequence="ACRWSPKATLGAPSAAHPPLAHSTTTTRLPRK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRGGAIGGG"
                     /leader_location="[7441:7468](-)"
                     /alternative_weights="3255.7"
                     /alternative_weights="3273.7"
                     /alternative_weights="3291.8"
                     /alternative_weights="3309.8"
                     /alternative_weights="3327.8"
                     /alternative_weights="3345.8"
                     /alternative_weights="3363.8"
     misc_feature    complement(7622..7635)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.12"
                     /tool="antismash"
     gene            7738..8550
                     /locus_tag="HUW46_RS32415"
                     /old_locus_tag="HUW46_06437"
     CDS             7738..8550
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020646821.1"
                     /locus_tag="HUW46_RS32415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06437"
                     /product="hypothetical protein"
                     /protein_id="WP_215542563.1"
                     /transl_table=11
                     /translation="MRTNPSHSELTRRTALRTLAVSALAVPVALSPLATADAAPLWHPD
                     PATDGMKAFEGVEADRGHHHPDRRYAYPEGDHYRFAIWADDRDTTGGGDRQRTEVKGMV
                     QNGTALKMRDGETWTISYETYLPSTLHGTSKFTHLFQTKTPSTNGGPWVTLDLTRDGGT
                     EMIRARAYANPGSPSIASTALAPLRDKWITVEWTLTPGAAGVAACVIRDGTGPAAPIAA
                     QGRRTGVKMPGQGDYVRPKWGIYRSVESARSDIVDTYLLFRAFKATRT"
     gene            8600..9994
                     /locus_tag="HUW46_RS32420"
                     /old_locus_tag="HUW46_06438"
     CDS             8600..9994
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336388.1"
                     /locus_tag="HUW46_RS32420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06438"
                     /product="polysaccharide lyase 6 family protein"
                     /protein_id="WP_215542564.1"
                     /transl_table=11
                     /translation="MTRTVPRRLGVVAAAGLFAVCGVQSASAGVTAPRTLAVSSSSQLA
                     EALAQARPGDRVQVAAGVYDAGPIRVGRSGTAQAPITIAAETGTARFTGAGGLDLTGAS
                     HVVVRGFVFDNDAGLTVPGDALGDRVTRNVFKGNPGKADLTVKADDTEVDHNRFENRTE
                     AGVYLQVVGPGAKDMAKRVHVHHNYFFNHQFHGTNGGESIRFGLSGRQHAVADGLIEHN
                     LFDKADGDSEAISIKSTKNVVRYNTITDSHGTISLRHGWNSVVEGNILTGGTTGIRFFG
                     NDHVIVNNIVKDTAGTPIEFGGGEVRDDTTSGTNHEAADHCLVAFNTLSGTDKIVWFND
                     GKPFPPSDGTLADNILLGKGKDAAKGAGEGSHFTGNILFGAPAGSLPSDAYRTIDPKLV
                     PDAHGLPRPTATSPVIGAATGSFPKVALDIDQQTRPGTKDVGADQYAKAAPARPLTPAD
                     VGPDAP"
     gene            complement(10001..13054)
                     /locus_tag="HUW46_RS32425"
                     /old_locus_tag="HUW46_06439"
     CDS             complement(10001..13054)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="HUW46_RS32425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06439"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_215542565.1"
                     /sec_met_domain="DUF4135 (E-value: 1e-94, bitscore: 316.9,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-44, bitscore:
                     151.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLRRRVLLTPNWSPALSLLERRAAPVTAGDDARERGRRRLAAWR
                     RDKLVTGGVEVDLDLWEEDEYLVLLGESPDQLSARLPEQPPWLTVLVEAWAHPEPAVVD
                     GVLALAAPLLGHFERQLRRDVAWLSPDHPLFVRDAKQLTTMVTPTLVREMHAARDRLTG
                     ETPEARFSSFVDLLRDKETSLEILSRHPVLARELVAELGSWATVRAEFAARLRDDLPSI
                     APGLTANDVTAVDFGAGDTHRGGRSVAVVTFDDGRRIVYKPRGLATERHFSAFLAWAND
                     RGLRHPLRHLQVFDRGKYGWTEFAEAASCTTEAEVARFFWRQGAQLALLHALRAQDMHA
                     ENLIAAGEHPVFVDLESVFVPPIRPHATETVLRVGLLPNRTVKEDAGNVRAVDMSGMTG
                     AQGTPTPMPLPHWVDAGTDRMRRERDHLTMPAADNHATLKSSTVDPWHHRAELLDGFTD
                     AYRLLARNRAELLADNGPIAAFSGAEARPILRSTMIYGRILLESWHPDVLGDALDRSCL
                     FELLAKGHQAVEGREELIASEIRQLTDRDIPAFTITVGSRDLRDETGVLVPDFYPVSGL
                     DAVREGLSELGEADLTRQRWCIEASLAALAGDGVAPGTPVVPRPLASPIDVPTAVEAAT
                     LIGDRLLDTALHDDGEPGWLTLRLAAEQHWVLAPTELDLYDGNAGIALFLAWLSELSGR
                     NRYRETAEAIAARIADATDRLADQPVGMFAELGGAVYTLATLGSLWHSDALLDAAADLV
                     PPLTAKLAEDTALDVMSGTAGAALAVAALHAIRPDERTERALLTAGTVLLDRAEPHPDG
                     LTVPTMGTRVPILGYSHGASGVVLALTRIALATGQDRFAEAAAAVLRYEHAQFDHVARG
                     WPDRRESTPDDAFMNAWCHGAAGIGIARAELLGDPAVAVDLDRAVDAARRDLLDETGTS
                     VIGFTHDSLCHGTLGLVETMLSDPASAETAKRVAGTVANSVLAGETRCDTPYSTWVPGL
                     MTGAAGIGYGLLRAAAPDRVPNVLAARS"
     misc_feature    complement(11645..11647)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13027..13191)
                     /locus_tag="HUW46_RS32430"
                     /old_locus_tag="HUW46_06440"
     CDS             complement(13027..13191)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS32430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_06440"
                     /product="hypothetical protein"
                     /protein_id="WP_215542566.1"
                     /transl_table=11
                     /translation="MLTEIADPIGRIELTDLDLGETASTADVAHVTMACTGSQCQETTM
                     QCHSAGGFC"
     gene            complement(13231..14067)
                     /locus_tag="HUW46_RS32435"
                     /old_locus_tag="HUW46_06441"
     CDS             complement(13231..14067)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /locus_tag="HUW46_RS32435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06441"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_215542567.1"
                     /transl_table=11
                     /translation="MKTRTWWRGAAVAAAFLSSAAVAAPAQAIINGTVATEDYSFVTSI
                     QREYKGDPTTQWCGGALVAPTLVVTAAHCVTKAGTNGAPYTPVDPGIYQVRVGSNDRTT
                     GGETAKVAGFEIIPGYVNSADRNDGKDIALVRLDHAVSKQPIPLAGITPAPGNAVRLIG
                     WGYTDIKQNNPTQLPKQLHRLDLPVVLPSTKQCVQDPATGSDAYGIRKGDFCAESRDHV
                     SGSCGGDSGSPVLQLVYGRFELAGVQSRAPGDICGQTPDINTSAPAYRDWITSVTG"
     misc_feature    14020..14029
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(14175..14606)
                     /locus_tag="HUW46_RS32440"
                     /old_locus_tag="HUW46_06442"
     CDS             complement(14175..14606)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025050.4"
                     /locus_tag="HUW46_RS32440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06442"
                     /product="VOC family protein"
                     /protein_id="WP_215542568.1"
                     /transl_table=11
                     /translation="MTTETPADRRSFYHVCFAVPDLRAAMDELAELAGLSWGEPVHSEL
                     GDWPYSLVFSREFPHIELISGGEGSPWYAERPGFHHLGWWTDCLDALPQSWDAAGALPC
                     FDGRDHGRRFLYADAPASGARLEAVDAKQRNDFLRRWAG"
     gene            14706..15362
                     /locus_tag="HUW46_RS32445"
                     /old_locus_tag="HUW46_06443"
     CDS             14706..15362
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645138.1"
                     /locus_tag="HUW46_RS32445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06443"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_215542569.1"
                     /transl_table=11
                     /translation="MDLFSRSWAALRAAVADLRDEDFARPSGCAGWLVRDLVCHLVIDA
                     QDVLITLVTPAETEPTRDAITYWAVAEEPPTGDDPLDALIVRLAAAYEDPGLLKFHLDD
                     VGSAAGRAADLADPGLRVSTQDQVLTAGDYLAAYVLEWTLHHLDLVADLPGAAGPPAEG
                     LAKTREMVEKIAGAAFPESFSDEDVLLVGTGRRAPTDAERADLGGLAAKLPLVLG"
     gene            15448..15918
                     /locus_tag="HUW46_RS32450"
                     /old_locus_tag="HUW46_06444"
     CDS             15448..15918
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS32450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_06444"
                     /product="hypothetical protein"
                     /protein_id="WP_215542570.1"
                     /transl_table=11
                     /translation="MRRIGSVLLGTLLLGGVCTATVGTAAAAERRADVKLTAAPSTVEV
                     PAGKPGTVKLTYSNIGNVPKVGSSITAPIPKGLTATARPAPGWTCHIDDWPSLVCDTDG
                     KLDPGAVVVPAEVDLSAAAPVSAGVEFGTLGFYRDPTENPADNYSTVQVRVS"
     gene            complement(15888..18161)
                     /locus_tag="HUW46_RS32455"
                     /old_locus_tag="HUW46_06445"
     CDS             complement(15888..18161)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333561.1"
                     /locus_tag="HUW46_RS32455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06445"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_215542571.1"
                     /transl_table=11
                     /translation="MSERATFGAELRRHRVAAGLSLTWLAERTHYSKGYLSKVETGLAT
                     PNAALAALCETELGIPGALIGFLPSGPKRRRTRPDTRPSGLPPLATDFTGRSTELRRVR
                     DALRTDSGLCVVSGMGGVGKTELAVRCAHRLEAEFSDGCLFVDLRGYDPEEPTASPDAV
                     HDRLLRVLGVPAALIPADPDDRTALYRSRLHGRSMLLVLDNAVSAAQVRPLLPGEPKCR
                     VLITSRSRLPAIDDACHVSLDVLPAPAAVELFSALTGLPPEDDVARVVECCGRLPLAIR
                     IAAARLRAHPAWNLGELDRRLHAEATRLDELDDGERTLSAVFRLSVRQLTTAESQLFRL
                     LALHPGDDFDVHTASAVSGLSLRETDRALERLHDTYLLVQPDVARYRFHDLLRTFARED
                     LLNGSAEQDRTRAFRRLAGYAVRNTANADRLLTPQRFQPAIEFEPDLPERVRLDDDEMA
                     LTWFQAEWPNLVALCRAANKRGEHDRCWQLAYFLRGFFFTSKLWDAWIATNRWARESAA
                     ALDNRWALATVTANLGVAMVDQGKLDEATVYYREALGLYRDLGDGHGESTMLAHRAWVA
                     HYRGHHDDALHDLRLARVCYERTGNRRNAAITNRGIALVMTALGQAVEAATVAIDILPI
                     FDELGLPLDAAMTQNCLGWAWFHTERDDLATAAYQDAVTRAVSCGSDYETARAYTGLGN
                     LAAARGEREVAAEFWARADEAHPGLDPVIVGENRARRSLAGATPQSGGSGSSPAQETRT
                     WTVE"
     gene            complement(18363..18740)
                     /locus_tag="HUW46_RS32460"
     CDS             complement(18363..18740)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS32460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215542572.1"
                     /transl_table=11
                     /translation="MDLDVQSITRHLRDRYPAVSFPADSGNGKLVVLAAPATAFLVSRN
                     DSAAKTLEDLGGARLLERCHGALAEGAEMTVTCSFSLLLRLLLWLSVSALLAGVLLAAA
                     PTPAPEVKSRSVVRTHGEEVR"
     gene            18794..19735
                     /locus_tag="HUW46_RS32465"
                     /old_locus_tag="HUW46_06447"
     CDS             18794..19735
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017981518.1"
                     /locus_tag="HUW46_RS32465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06447"
                     /product="hypothetical protein"
                     /protein_id="WP_254125101.1"
                     /transl_table=11
                     /translation="MSALEVVEELKRLRRGRGIAAPQLGDHVGPALRVVCDIYEDEDSE
                     SIRGKVSERLQALVTSLADDLRMAVLAAFGLHEQARSLFYKDRVRWLAEKLDRDDRTIR
                     RRIDQGIQQVAALAIATGRSTDLPHPSRSWHTEDLRVTLALDQPVPEAFEFRRVVADAD
                     DIDELDLALTLTTPDARVPVDEADLQVDVFHGGSLTRRMMESSDRVGLALRLPSPLRRG
                     ERHEVALRFRAALRYPHYVCVPRHPVDHFELHVRFARPTPAEIVLLDNVFQDDARNHAV
                     RGPSLSPDGSGEVHVDFRKLAPGFAYGVRWQD"
     gene            complement(19747..20940)
                     /locus_tag="HUW46_RS32470"
                     /old_locus_tag="HUW46_06448"
     CDS             complement(19747..20940)
                     /GO_function="GO:0003953 - NAD+ nucleosidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025056.4"
                     /locus_tag="HUW46_RS32470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06448"
                     /product="toll/interleukin-1 receptor domain-containing
                     protein"
                     /protein_id="WP_215542573.1"
                     /transl_table=11
                     /translation="MPIEERLGTGPTVFVSYTHDDEDHRRAVLKFATVLQNSGIAVTLD
                     RWASDRRRDWQAWAVKGMTECDYVIVIASKDYRRMGDGNGPNDLNLGGQSEAALLRDLL
                     QGDRQAWTVKILPVILPGQDISGIPLFLQPNAADRYAVDSITPEGIEDLLRVITSQPRH
                     VRPPLGPPLVLPPQTGPGSMPDATWSVLSQAVPVNWLPELLPRQGPAQPPLVELHLVPV
                     DPPVRLRVRQLEALRDELPSVGRSRRLFSPSEGLTVDSSHDAVWAYASNRDGSTGLAVY
                     RSGQRTCWFPATPATIGWLLDRDDLIDQLTDHLGLLADLGLSLPGKIAPTIGMTPTDFV
                     RVGKLGEAAATSVSVPMAQPHEVRFDADEAVAAEDLRTSARSIAQELAARLVRALTG"
     CDS             complement(21000..21116)
                     /gene="allorf_06814352_06814468"
                     /locus_tag="allorf_06814352_06814468"
                     /protein_id="allorf_06814352_06814468"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MINEGKNLVTGRITSAGQSMKCPCSVRFSRTTATNGQR"
     CDS_motif       complement(21084..21116)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MINEGKNLVTG"
                     /locus_tag="allorf_06814352_06814468_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(21000..21083)
                     /prepeptide="core"
                     /locus_tag="allorf_06814352_06814468_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.90"
                     /molecular_weight="2800.2"
                     /monoisotopic_mass="2798.4"
                     /core_sequence="RITSAGQSMKCPCSVRFSRTTATNGQR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MINEGKNLVTG"
                     /leader_location="[21083:21116](-)"
                     /alternative_weights="2818.2"
                     /alternative_weights="2836.2"
                     /alternative_weights="2854.2"
                     /alternative_weights="2872.3"
                     /alternative_weights="2890.3"
                     /alternative_weights="2908.3"
     gene            21144..22535
                     /locus_tag="HUW46_RS32475"
                     /old_locus_tag="HUW46_06449"
     CDS             21144..22535
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019956.4"
                     /locus_tag="HUW46_RS32475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_06449"
                     /product="SEFIR domain-containing protein"
                     /protein_id="WP_215542574.1"
                     /transl_table=11
                     /translation="MPDPDSAASRPRVYVSYACEESDEHVSLVREFAAFLRTEAGVDAH
                     LDQWYADGRRDWVAWASDQFQQADFIVVIASPGYGLTMGMLDTAMLHDKLGRSLPDATH
                     QILPVVLPGGSATDIPHVLSAFAATHYVVRAFSLDEVQGLLRAIHGSPAHAMPPLGAFR
                     PPDVEAGPVLVATPRSPPRTGRHLGPGAEVVIGDDHYLVHAGTYEETTTSDGAAVLRGA
                     RALSVGGPRPQVWLRQLEIRQDTPMAEEAATALTCERTLLASPAGRWLGILVSPALVRE
                     PGLVTLVTGWPLSGRTRGPCDTLASFVPERGELADPLRTRAILRGLGGLCRKLAALHRM
                     DASHRCLAPAAIIRLDDGALALRDLGLATTSYEPGEGPELYRAPEQGRRRRGKAGPWTD
                     AYQIGAIAYHFATGHPPPSIPVPVRGLAPDLPPAATAAIDAALDAEPSRRPGILALGAA
                     FDSSR"
ORIGIN
        1 caccgaccgc gggcggctcg ccagcgagga ggggctcggg tccggttacc cgctgcgcgt
       61 cgcgggcgaa tgggggttcc ggcacccgga acgcaccatc acctggctga acacggcgat
      121 cgcggacaac aaggtgtcgg atctcgaagc ccgctggcag gcggacgtgc tcgacgcgcg
      181 cccggacgtg gtgtcgatcc tcgtcggcat caacgacgtc ggctggcact cgtacgaccc
      241 ggacggccgc gtgatcggag cggcggagta cgcggccggg tacgaccgcc tgctcgcccc
      301 gctggccgag accggcgccg agctgatcct catcgagccg ttcctgctcc cgatccgcgg
      361 cagcgtcgaa gtcggcgacg cgcacctcgg cgaaaaagtc aggaaggagt ggcgcgcgga
      421 cctggacccg aagatccagg tcgtgcgcga actcgccgcc aaatacggcg cgcacctgct
      481 cgccgccgac ggcatgttcg ccgggctcgc cgcgaagacc gggccggagt actgggcggc
      541 ggacggcgtg catccgacac cggccgggga cgccgcgctc gccgcagcct ggttgcactt
      601 ggtggattag acgatccggc ggagcgcttc ctcgtccctg ccgaccacgg cggtctgccc
      661 gtcgaccagg atcggccgct ggatcagcac cgggttgtcc gccagcagcc cgatccagcg
      721 ttcgcggttc gcggcgtcgc gcggcaggtc cgcgaggccg agctccttcg cgacgggttc
      781 ggcggtgcgc gtgatgtccc acggctccgc gccgagcttg ccgaggacct cggtgagctc
      841 ggccgcggtc ggcggggcgt cgaggtagcg gcgctcggtg tactccgcgc cggagtcgtc
      901 gagcgccttc ttcgcggccc gcgacttgga gcagcgcggg ttgtgccaga tctccatgcc
      961 accatcatcg gtggtcacga tgggcggcac cgcaccgggt tctgcagatc ggcgcacggg
     1021 cggtggccgt gggagcggat gatgtccatg ccgacctggt tggtcaggta gcgcaggaag
     1081 ctggcggcga gggagtcgga cttgggctcg ctgaaggtgt aggcgtattc ggtctgccag
     1141 aaggggaaca tcccgcggtc cgtcgtgtcc aaagtggact gctggccgtc gatgcgcacc
     1201 ttgacgacgt cctgcttcgt cttctggcgg tccgtggcgg cgccgagttc gacgtacccg
     1261 atcgagccgg gtgtgttcgc gacggcgttc agcaccgcgg tcgtgtcccc ttggcggcag
     1321 cgggtgacct ggccgcgcag gtcggtcttc ggctgctcgc agtcggtgga gttctcgccg
     1381 ggctcgctga acccgaggac gcgttgttcc agggtggccc tggtgccgga cgaggattcc
     1441 cggtcgacga ggcggaccgg caggtcgttc ttcgccccga tgtccttcca cgcgccgacc
     1501 cgtccgccga agacgtcttt gacctgagcc agggtgaggt cctcgacacc ggtgttcttg
     1561 ttggccacca gggtgaagag ctggagcgcg accgggcgct ggatcagctc ggggagcttc
     1621 tgccccttca cctcggtctt cagcccgtcg gaaaacgcca ccacgtccgg gctcctgctg
     1681 ttgttcagct gctcgaggcc gttggtgctg ccggtcatct cggcctggaa accgcttccc
     1741 tggcaggatt tcgcgtaggc ggccatggcc tcccgcacga tgggttcgaa ggccgtcgag
     1801 ccggtgaccg tgagccgacc cgtcgcgcag tccagcggcg ctggtttgtc gctgaactga
     1861 tcgaggacga agggttcggc ggaggcgatg gccacgagcg cgacgatcag cgcgacgatc
     1921 caccgtggta tgccggtgaa gctctcggtc ttcttgatct ccccgctccc gagaccggtc
     1981 ttgatgctgc cgtcgaccgt ggggtgggcg agttcgccgc cgtcggggct ttcgagaacg
     2041 gccagcacct tgtagtgctg gccggggttc aacgggaccc tcggcagctc gatgacacct
     2101 tcggtctgtc ccggactctc gacgtttcgc gtgttcaacc ccgaatcggg actgaagtgt
     2161 gcggtcgaaa gcgtcttgtg gagatcggcc accaccagtc cggccacggt gcgtcccggg
     2221 aacttgaacc tgatcccgac tttggattcg ttggggctgg cgtagtcgtg ggtgtcgatg
     2281 ttcgtcgtgc cggtgttttc tatgcgcagc aggacgaacg acgggttctg cagcggtgtt
     2341 tcgtcgtcgt tctccagttg cagctgctgc cacgcgcccg cgtgctccct gccgacgtcg
     2401 gtcgccgtcg cgttcatctg gatccggtag ccgagctgct tgcggccgac gaaggcgaac
     2461 tcccacagga acgcgacgat cgggacgagc gcgccgacca gcgccaggac cagttcccag
     2521 ggaaagtcgg ccacgaccgc ctccggtatc gggggagcac gcaaaggacc gaaccaccgt
     2581 agtgagcgcg cgggacgtca caccgcgttc cggcgggctt ttcgcctgct gttcaccggc
     2641 cgttgtccgc gcacccgcgc tgacaccgcg tgccaggtcg gtaccaggcg ggtgtgcgcg
     2701 ccctgccagc gcgcggcacc agtctcgggg gcatgcctca gtcaactcat gtcacgatca
     2761 tcggcgccgg tctcgccggc ctcaccctgg ccagggtcct gcacctccac ggcatccgcg
     2821 ccaccgtcca cgaagccgaa ccttccccgg ccgcgcgcgc tcagggcggc atgctcgaca
     2881 tccacgacta caacggccaa cgcgccgtcg aagcggcgga tctgatggac gagttccggg
     2941 aactggtcct ggagggccgc caagcgatgc ggttcgtcgg caaggacggg accgtcgtgt
     3001 tcgagaaggc cgacgacggc accggcggcc gtcccgaggt gcagcgcggc gagctgcgcc
     3061 agctgctgct cgactcgctc ccgcccggca ccgtcgagtg gggccgcaag gtcgacggcg
     3121 tccgcgacct cggcgatggc cgtcacgagg tgggcttcac cgacggcacc acgaccgaaa
     3181 cgagcctgct ggtcggcgcc gacggcgcct ggtcccgcgt ccggccgcta ctgtccggtg
     3241 ccgtaccggc gtacaccggg gacacgttcg tcgagacctg gctgcacgac gccgacgagc
     3301 gccacccggt cgccgcgaag accgtcggcg gcgggaccct gatcgcggcg gagcaggacc
     3361 gggcgatcaa cgcccatcgg gagcgcggcg ggaccctgca cacctacgtg atcctgacca
     3421 ggtcccagga gtggttcgcc gcgatcgact tcacggaccc cgtcgtggcc accgcccgga
     3481 tcgcgggcga gttcgacggc tgggcaccgg agctcaccgc gctgatcacc gacgccgaca
     3541 ccgcacccgt tccgcgcccg atcttcgccc tgccgaccgg gcaccggtgg gaccggcggc
     3601 cgggggtgac cctcatcggc gacgccgccc acctcgcggc cccggacggt gaaggcgcca
     3661 acaacgcgat gctcgacggc gcggaactcg gcgccgctct cgccgcgcac ctcggcgacg
     3721 tcgaagcggc tctcaccgag ttcgaggacg cgatgtccac ccgcaacgcc acgcccaccg
     3781 acggcgccga gttcgtcgag gaggtcttcg gcggcaccct gccccaggaa ctgagcgacc
     3841 tgatcaccgg gttccagcag caaccttcgt gatccggttc cggtcgacgg ggacgccggg
     3901 cctgccgcgg acaagaggga gcgacagggt ggcacagaac ccgcggaggc aggggacatg
     3961 acgctgggac aggtactggc gaacgaggtc ggcgcggcgg tggtgacggt cgcggtgcac
     4021 gcgtcggatc cgttgaccgg gctcggtgcg gcgagcatct tggacgccga cgcgcggctg
     4081 agactgctcg gcggcggcga atccgcctcc gccgaggtga tcgtggtcgt cgaagactcc
     4141 gtcgacgacg gcaccttcgc gctcctgcgc gagatccgcg acgcgtcgcg gctcgaccac
     4201 ccgccgcggt gcgtcatcgt caccgaccac ttccggagcg aagtgctgat gacggcgatc
     4261 gaatgcggga tgtccgcgtt gctgccgcgg cgcacgatga ccggggagga cctggcgcag
     4321 gccgtcgtcg cggtcagcag gggcgtggcc cagctgccgc cgcggctgca gggcgatctc
     4381 ctggagcggc tcgaccgcat gcggcgcgat gtgctcgaac cccacggcct gacgctgctg
     4441 gggctgtccg tgcgcgagcg ggaagtgctg cggttgctgg ccgacgggca cggcaccgag
     4501 gagatcgcca tcaggctgac ctactcggag agcaccgtga agaacgtgct ccacggcctc
     4561 atgcgccgct accacttcac cacccgggcc cacgcggtcg ccttcgccgt gcgggccggc
     4621 gtgatctagc ttgcgaaagc ggcctcagct cagcccggcg cggcagcacc gcggcgaccc
     4681 ggcacggatc tcgcgcagga cggtcagtcc tcaatggacg ctcggcaggg cggatccttc
     4741 ggatggagta agagccgggc tcgcccccgc cgtatcgccg catccgatcg agtgatggcg
     4801 gtagcgcggc cggtcgctgc tgctaaagag gtgacatgcg attcctcccc gctgttctat
     4861 ccgccttgtt gttgaccgct acgacaggtg tcgccgtcgc ggccccggcg cgatccgccg
     4921 ggcacgggca cggtcaccac atctacgctc gcggcacgtt cgcgctctac acgccgggcg
     4981 cgaacgccat cacccacgac cccaagctcg cccccgtcgg ttcgaaggtc gtcgtttccg
     5041 ggtacacgaa cgcgcaccgg accaagacca ggctgtacgt caagggcctg ctccccgacc
     5101 gcgagtacgg ttctcacgcg cattccaagc cctgcggtga gaaggcggcc gactccggcc
     5161 cgcaccacca gcacgtccag gaccccgtgc agccctcggt cgacccgaag tacgccaacc
     5221 cggacaacga gatctggctc gacttcacca ccgaccacga cggcaccggc tacgcggagt
     5281 ccacagtgga ctggggattc gacggggagc ggcacgccca gtcggtcgtc atccacgaaa
     5341 cgcacaccca caccgagccc ggccacgccg gaatggccgg agcgcggctc gcctgcataa
     5401 acgtgggctt ctgacgagtg cttcggaaac agcgcgggac cgcggcgacc acgccgcggt
     5461 cccgtctcaa gccggtacgg cccgcagcga gtcggagagg gtgaccagtt cgcggacgtc
     5521 gtcgtcgagg ctgtcgccat cgggcatcgc gacgggcatc gcctccggtg ccaccgtttc
     5581 ccctcgcgcg tgcgagcgca acgcttcgcc gagccgttcc gccaggtcgc cgtcgtcgcc
     5641 gaggtgcgcg aggtacgggc tgagccggac cagcccgtcc cggcattcga tcgcccgccg
     5701 gtagtacctg cggtgcacgc cgcgcaggct cagcgcgtcc cgccacgggt tgagcggcgc
     5761 gcggctcagc gcgtcctccg ggaaggcctc gtgcagcgcg gtccacagtg gaccgagccg
     5821 gtggtaggtc cgcaggtgct gccgccacac gcggcccgcg gcgagcctgg tcgcgacacc
     5881 ggggtaggac aggccgatga ccagcagcag cgccccgggg aacaccagga acacggtgcc
     5941 ctgcacgagc agccacggga tggccgcgcc ggtccagtgc acgaggacca ccgcgaccag
     6001 cgtcgacccg ccgaccgcgg agatggcgaa cccgacggaa gccacccgca ggccacgtgc
     6061 cagccggggc ccggcgccgc gcgcgtagcg ccgcgtgaag aagtacgcgc tcgcgatgcc
     6121 gtaggtgagg tagaggtcgg cggcgaggta gaacgtcaag accccggcga gggggtaccg
     6181 cgcgggcggg acgtccggca tgaacaccgc cacgagcacc atcaccagca tcgcgacggc
     6241 gaacgggatc gcctccagca gggcgcgccg ccgcgcttcg gcgaccggga gcgccgagaa
     6301 caggaagaag caggccaggg tgtagaccag cccgcacagg aagaagtgct ggaacagcag
     6361 cggcacgatc gggccggggt tcggctggtt cacgttcccg gcgaggaagc cgaacgggta
     6421 cgcggccgcg aagcaggcga ggcacgcggt gaccatccag cgcgccacgt ccttcggcgc
     6481 gcgggtgagc tggtagatct tccacagcag ggcggggtag aggatcacgc cctggagcac
     6541 cgtcagcgcg acgttggagt tcacaaccag cccagccgtt cgcccagcgc ggtctcgatc
     6601 cgccgcgcgg tggcctcgtt cgaggactcc ggggtgaccc ggtccagcac ggacgcccat
     6661 tccaggatga tcgtcgccac cgtctccgct tcccgctcgt ggtcggtgtc gtaggaggtg
     6721 cgccgcagcg cgtgccggac cgattccggt tccaggtccg ggtactgctc gcgcgggtgg
     6781 cccggcgggg gcgcgctcgg ggccagctcc gtgaccaggc cgtcgtcctc cgcggtggcc
     6841 acgtgcccgg ccagcatgtg ccccagctcg tgcaggatga tgtggcactg gtgggccttg
     6901 ctcgtgtcct gctggtacac gatgtagtcg gccttgccgg tggcgatcca ggcgccgaac
     6961 gggcccggca ccgggatccg gtgcgcgatc agccggatcg ggcggccgcg ctgctccccg
     7021 accttgcggc acagttcgag gacgtcgagc ggcgggcgga tgccgagttc gttcagcagc
     7081 cgcctgcagc ggcgccgcag cttgcgttcc tgcaccagtc accccgccgt cggtgtgagt
     7141 ggccccgtcc ttcgaagcat cccttaaacg gtagcgacct gaacgggggc cgttcacccc
     7201 cgaccccacc ttcactcgtt cgccagcccg ccgatccgga tcttgggcgc gcccggaact
     7261 tttccggcgc cgaggcgcgc gagccgtagc gggcgttcgc gcgccccgaa ggtggcattc
     7321 ggggaatcca gtgccccgaa ggtcactttc ggggcaggcg tgtcgtggtg gtcgagtgtg
     7381 cgaggggtgg atgtgcggcg ctaggcgccc cgagggtggc cttcggggac caacgacagg
     7441 ctccgccgcc gatcgccccg ccgcgcaccc ggcatcactg tgacgttcgg ggaatccagt
     7501 gccccgaacg tcacagtggg ggcatcggca gtcgcttctc cggggcaggt gctccgatga
     7561 atggcacacg atcccttccc gtcaaggtgg aactccgcgc agcgttgaca gtacacagcg
     7621 ctactcatat ttttagctcc gggaagacat cggatgttcc ttccggggcg cgtggcccgg
     7681 cgggactccg ccgaccgatg tgccccctgt cgaactgccg tcaggaagga cacaccgatg
     7741 aggacgaacc cgtcgcacag cgaactcacc cggcgcacgg ccctgcgcac gctggccgtt
     7801 tccgcgctcg ccgttcccgt cgcgctcagc ccgctcgcca cggccgacgc ggccccgctc
     7861 tggcaccccg acccggcgac ggacgggatg aaggccttcg aaggcgtcga agccgaccgc
     7921 ggccaccacc acccggaccg caggtacgcc tatcccgaag gcgaccacta ccggttcgcc
     7981 atctgggccg acgaccgcga caccaccggc ggcggcgacc gccagcgcac cgaggtcaag
     8041 ggcatggtgc agaacggcac cgcgctgaag atgcgcgacg gcgagacgtg gacgatctcc
     8101 tacgagacgt acctgccgtc gaccctgcac ggcaccagca agttcacgca cttgttccag
     8161 accaagacgc cgtcgaccaa cgggggcccg tgggtgaccc tcgacctgac gcgcgacggc
     8221 ggcaccgaga tgatccgcgc acgcgcctac gcgaaccccg gctcgccgtc catcgcctcg
     8281 accgcgctcg ccccgttgcg ggacaagtgg atcaccgtcg aatggacgct gaccccgggc
     8341 gccgcggggg tcgcggcgtg cgtcatccgc gacggcacgg gaccggccgc gccgatcgcc
     8401 gcgcaaggca ggcgcaccgg cgtgaagatg ccgggccagg gcgactacgt ccgcccgaag
     8461 tggggtatct accgctcggt cgagagcgcg cggtccgaca tcgtcgacac ctacctgctc
     8521 ttccgcgcct tcaaagccac ccgtacctga ccgtccactg tggattttca ggccgccgcc
     8581 ccgatccgga ggagcagaca tgacccgaac cgtgccgagg aggctcggcg tagtggccgc
     8641 ggccgggctg ttcgccgtgt gcggcgtgca gtccgcgtcg gcgggcgtga cggcgccgcg
     8701 cacgctcgcc gtgtcgtcgt cgagccagct ggccgaggcg ctggcgcagg ccaggccggg
     8761 tgaccgtgtc caggtggcgg ccggtgtcta cgacgcgggc ccgatcaggg tgggccgctc
     8821 gggcaccgcc caggcgccca tcacgatcgc cgcggagacg ggaacggccc ggttcaccgg
     8881 ggcgggcggg ctggacctga ccggcgcgtc ccacgtcgtg gtgcgggggt tcgtgttcga
     8941 caacgacgcc gggctgaccg tgccgggcga cgcgctgggt gaccgggtca cgcgcaacgt
     9001 gttcaaggga aatccaggaa aggccgacct gacggtgaag gccgacgaca ccgaggtcga
     9061 ccacaacagg ttcgagaacc gcacggaggc gggcgtctac ctgcaggtcg tcgggccggg
     9121 ggcgaaggac atggcgaaac gggtgcacgt gcaccacaac tacttcttca accaccagtt
     9181 ccacggcacc aacggcggcg agtccatccg cttcggcctg tccggcaggc agcacgccgt
     9241 cgcggacggg ctgatcgagc acaacctgtt cgacaaggcg gacggggact ccgaagcgat
     9301 ctcgatcaag tcgacgaaga acgtggtgcg gtacaacacg atcaccgaca gccacggcac
     9361 gatctcgttg cggcacgggt ggaattcggt cgtcgagggg aacatcctca ccggcggcac
     9421 caccgggatc cggttcttcg gcaacgacca cgtcatcgtc aacaacatcg tcaaggacac
     9481 cgcgggcacc ccgatcgagt tcggcggcgg cgaggtccgc gacgacacca ccagcggcac
     9541 gaaccacgaa gcggccgacc actgcctggt cgccttcaac acgctttccg gtaccgacaa
     9601 aatcgtctgg ttcaacgacg ggaagccgtt cccgccgtcg gacggcacgc tcgccgacaa
     9661 catcctgctg ggcaagggaa aggacgcggc gaagggtgcg ggtgaggggt cccatttcac
     9721 cggcaacatc ctgttcggcg cacccgcggg aagcctgccg tcggacgcgt accgcacgat
     9781 cgacccgaag ctggtgcccg acgcgcacgg gttgccgcgg ccgaccgcga ccagcccggt
     9841 catcggcgcg gcgaccggct cgttcccgaa ggtcgcactc gacatcgacc agcagacccg
     9901 gcccggcacc aaggacgtcg gcgccgacca gtacgccaag gcggcgccgg cgaggccgct
     9961 gaccccggcc gacgtcggcc ccgacgcgcc gtagcggtgc tcagctgcgc gccgccagca
    10021 cgttcggcac ccggtcgggg gcggcggcgc gcagcaggcc gtagccgatc ccggcggcac
    10081 cggtcatcag tcccggtacc cacgtgctgt acggggtgtc gcaccgggtt tccccggcca
    10141 gcaccgaatt cgcgacggtg cccgcgaccc gtttcgcggt ttcagcactg gcgggatcgc
    10201 tcagcatggt ctccaccagc ccgagcgttc cgtggcacag cgagtcatgc gtgaacccga
    10261 tgaccgaggt gccggtctcg tcgaggaggt cgcgccgcgc ggcgtccacc gcccggtcca
    10321 gatccaccgc gaccgcggga tcgccgagca gttcggcgcg ggcgatcccg attccggcgg
    10381 cgccgtggca ccacgcgttc atgaaggcgt cgtccggcgt gctttcgcgg cggtccggcc
    10441 agccgcgtgc cacgtggtcg aactgggcgt gttcgtaacg gagcacggcg gcggccgctt
    10501 cggcgaaccg gtcctgcccg gtggccagcg cgatcctggt cagcgccagc acgacaccgg
    10561 acgcgccgtg ggaatagccg agtatcggca cgcgggtgcc catcgtcggc acggtgagtc
    10621 cgtccgggtg cggttcggcc cggtcgagca ggacggtgcc cgccgtcagc agtgcgcgtt
    10681 ccgtgcgctc gtccggccgg atcgcgtgca gcgcggcgac cgcgagtgcg gcacccgcgg
    10741 tgccggacat gacatccagt gcggtgtcct cggcgagctt cgcggtcagt ggcggaacga
    10801 ggtccgcggc ggcgtcgagc agcgcgtccg agtgccagag cgaaccgagc gtggccagcg
    10861 tgtagacggc gccgccgagt tccgcgaaca tcccgacggg ctggtccgcc aggcggtctg
    10921 tggcatccgc aatcctcgcg gcgatcgctt cggcggtctc gcggtaccgg ttccgcccac
    10981 tcaattcgct gagccaggcc aggaacaggg cgatacccgc gttaccgtcg tacaggtcga
    11041 gttcggttgg cgcgagcacc cagtgctgtt cggcggcaag acgcaacgtg agccaccccg
    11101 gctcgccgtc gtcgtgaagc gcggtgtcga gcagccggtc gccgatcagg gtggccgcct
    11161 cgaccgcggt gggcacgtcg atcggagacg cgagcgggcg tggcactacc ggcgtaccgg
    11221 gtgcgacgcc gtcaccggcc agcgcggcga gcgatgcttc gatgcaccag cgctgcctgg
    11281 tcagatcggc ttcgccgagc tcggagagtc cttcgcggac cgcgtcgagc ccggacacgg
    11341 ggtagaagtc cggtaccagc acgccggttt cgtcgcgcag gtcgcgcgag ccgacggtga
    11401 tggtgaacgc ggggatgtcc cggtcggtga gctgccggat ctcgctggcg atcagctcct
    11461 cgcgaccctc gaccgcctgg tgccccttgg cgagcagctc gaacaggcac gatcggtcga
    11521 gcgcgtcgcc gagtacgtcc gggtgccatg actccagcag gatccggccg tagatcatcg
    11581 tcgagcgcag gatcggccgc gcctcggcac ccgaaaacgc cgcgatgggg ccgttgtcgg
    11641 cgagtaactc ggcccggttc cttgcgagca gccggtaggc gtcggtgaac ccgtcgagca
    11701 actcggcccg atgatgccac gggtctactg tggacgattt gagcgtcgcg tggttgtcgg
    11761 cggctggcat cgtcaagtgg tcgcgttcgc gccgcatccg gtcggtgccc gcgtcgaccc
    11821 agtgcggcaa cggcatcggc gtcggcgtgc cctgcgcgcc ggtcatcccg ctcatgtcca
    11881 ccgcgcggac gttgccggca tcctccttga ccgtccggtt cgggagcagg ccgacgcgga
    11941 gcacggtttc ggtggcgtgc ggccggatcg gcggcacgaa gaccgactcg aggtccacga
    12001 acaccgggtg ctcaccggcg gcgatcaggt tctccgcgtg catgtcctgc gcgcggagcg
    12061 cgtgcaggag cgcgagctgc gctccctgac gccagaagaa ccgggcgacc tcggcttcgg
    12121 tggtgcagct cgcggcctcg gcgaactccg tccagccgta cttgccgcga tcgaagacct
    12181 ggaggtggcg aagtggatgg cggagccctc ggtcgttcgc ccaggccaag aaggcggaga
    12241 agtgccgttc cgtggccaat ccccgtggtt tgtagacgat tcgccgtccg tcgtcgaacg
    12301 tcaccacggc gacgctccgg ccgccgcggt gggtgtcccc agcgccgaag tcgaccgccg
    12361 tcacgtcatt cgcggtcagg ccgggcgcga tcgacggcag gtcgtctcgc agccgtgcgg
    12421 cgaactcggc gcggacggtc gcccacgaac ccagctcggc caccagctcc ctggcgagca
    12481 cggggtggcg cgagaggatt tcgagcgagg tttccttgtc ccgcaacagg tccacgaagg
    12541 acgaaaagcg ggcttccggg gtctccccgg taaggcggtc ccgtgccgcg tgcatctctc
    12601 gcaccagcgt cggggtgacc atggtggtca actgcttggc gtcgcggacg aacagaggat
    12661 ggtctggcga cagccaggcg acatcccgcc ggagctggcg ttcgaaatgg ccgagcagcg
    12721 gtgcggcgag cgcgagcaca ccgtccacaa cggccggttc cgggtgggcc catgcttcga
    12781 cgagcacggt cagccatggt ggttgctcgg gaagccgggc gctgagctgg tcgggggatt
    12841 cgcctagcag caccaggtat tcgtcctctt cccagaggtc gaggtcgact tcgacgccgc
    12901 cggtgacgag cttgtcccgc cgccacgcgg cgagcctgcg cctaccgcgc tcgcgggcgt
    12961 cgtcaccggc ggtcaccggc gccgccctgc gttcgagcag ggacagcgcc ggtgaccagt
    13021 tcggagtcag cagaaccctc cggcggagtg gcactgcatc gtggtctcct ggcattggga
    13081 gccggtacaa gccatggtca cgtgcgcgac gtcggccgtg ctcgcggtct ctcccagatc
    13141 gaggtcggtg agttcgattc tgccgatcgg gtcggcgatt tcggtcagca ttcggttttc
    13201 tccttggttt cgatgacgga tcttcgaggg tcagccggtg acgctggtga tccagtcccg
    13261 gtaggcgggg gcgctggtgt tgatgtccgg ggtctggccg cagatgtcgc cgggcgcccg
    13321 gctctgcacc ccggccagct cgaaccggcc gtagacgagc tggaggacgg gcgaaccgga
    13381 gtcaccgccg caggagcccg acacgtggtc gcgggactcg gcgcagaagt cgcccttccg
    13441 gatgccgtag gcgtcgctgc ctgtggcggg gtcctgcacg cactgcttcg tcgacgggag
    13501 caccacgggc aagtcgagcc ggtgcagctg cttgggcagc tgggtcgggt tgttctgctt
    13561 gatatcggtg tagccccagc caatcagccg gacggcgtta cccggtgcgg gagtgatccc
    13621 cgcgagcggg atcggctgct tcgacaccgc gtggtcgagc cgcaccagcg cgatgtcctt
    13681 gccgtcgttg cggtccgcgc tgttgacgta gccggggatg atctcgaacc cggcgacctt
    13741 cgccgtttcc ccgccggtgg tgcggtcgtt ggagccgacc cgcacctggt agatgccggg
    13801 atcgaccggc gtgtagggcg cgccgttcgt gcccgccttg gtaacgcagt gcgccgcggt
    13861 caccaccaag gtcggcgcga cgagggcacc accgcaccac tgcgtggtcg ggtcgccctt
    13921 gtattcgcgc tggatcgagg tgacgaacga gtagtcctcg gtcgcgacgg ttccgttgat
    13981 gatcgcctgc gcgggcgccg cgaccgcggc gctgctcagg aaggcggcgg cgacggccgc
    14041 gccgcgccac caggtacgtg ttttcacttc cgggttttcc ttcccccagg tgaaggtgtt
    14101 ccgacgcgat catcctgcca gccggagccc tcgtccgggg cgaaaatccg caaaatgtac
    14161 tagaccgtgt gctcctaccc ggcccagcgc cgcaggaagt cgttgcgctg cttggcgtcg
    14221 accgcttcca gccgtgcgcc ggaggcggga gcgtcggcgt agaggaagcg gcggccgtgg
    14281 tcgcggccgt cgaagcaggg gagcgcgccg gccgcgtccc agctctgcgg cagcgcgtcg
    14341 aggcagtcgg tccaccagcc gaggtggtgg aaaccgggcc gttcggcgta ccacggggat
    14401 ccttcgccgc cgctgatcag ctcgatgtgc gggaactcgc gggagaacac cagcgaatac
    14461 ggccagtcgc cgagttcgct gtgcaccggt tctccccagc tgagaccggc cagctccgcg
    14521 agttcgtcca tcgcggcgcg cagatcgggc acggcgaagc acacgtggta gaagctgcgg
    14581 cggtccgcgg gggtttcggt cgtcatcggg cctccggtcg gtagtcggcg atggcgcgcc
    14641 cagcctagga cggccgccac ctcggtggct tgtgcgtcct tcccggaccg cactacgttg
    14701 ccggtatgga tctcttctcg cgctcgtggg cggcgttgcg cgcggcggtc gccgatctcc
    14761 gggacgagga cttcgcacgg ccgtccgggt gcgcgggctg gctcgtgcgg gacctggtgt
    14821 gccacctggt catcgacgcg caggacgtgc tgatcaccct cgtgaccccg gccgagaccg
    14881 agccgacccg tgacgcgatc acctactggg ccgtcgccga agagccgccg accggtgacg
    14941 atccgctcga cgcgctgatc gtccggctgg ccgccgcgta cgaggatccg gggctgctga
    15001 agtttcacct cgacgacgtc ggctccgccg cgggacgggc cgccgatctc gcggaccccg
    15061 ggctccgcgt cagcacgcag gaccaggttc tcaccgcagg cgactacctc gccgcctacg
    15121 ttctggaatg gacgctgcac cacctcgacc tggtcgcgga ccttcccggg gcggcgggtc
    15181 ctcccgccga ggggctggcc aagacgcgcg agatggtgga gaagatcgcc ggtgccgcgt
    15241 tcccggaatc cttttcggac gaagacgtgc tgctggtcgg caccggaaga cgcgccccga
    15301 cggacgcgga acgggcggat ctcggtggcc tggcggcgaa actcccgctc gttctcgggt
    15361 gatcggcaac gcgcacgggg agtcgtgcgt ggacaaggag aatggcactc gtcgggggtg
    15421 tcgtcacgac agggtggagg aagaagcatg cggcgaatcg gttcggtcct gctcggcacg
    15481 ctcctgctgg gcggcgtctg cacggcgacg gtgggcacgg cggcggccgc ggaacgccgc
    15541 gccgacgtga agctgaccgc cgcaccgtcc acagtggagg ttccggcggg caaaccgggc
    15601 accgtcaagc tcacctactc caacatcggg aacgtgccca aggtcggcag ctcgatcacc
    15661 gccccgatcc cgaagggcct caccgccacc gcgcgcccgg cgccggggtg gacctgccac
    15721 atcgacgact ggccgtcgct ggtctgcgac accgacggca aactggaccc tggcgccgtc
    15781 gtcgtccccg ccgaggtcga cctgtctgcc gccgcacccg tttccgccgg ggtcgagttc
    15841 ggcacgctcg ggttctaccg cgaccccacc gagaacccgg ccgacaacta ctccaccgtc
    15901 caggtccgcg tttcctgagc cggggaacta ccggatccac cggactgcgg tgtggctccg
    15961 gcgagcgaac gtcgcgcgcg gttttccccg acgatgactg gatccaggcc ggggtgggct
    16021 tcgtcggcgc gcgcccagaa ttccgccgct acctcgcgtt cacctcgtgc ggccgcgagg
    16081 ttgccgaggc cggtgtaggc gcgggctgtt tcgtagtcgc ttccgcagga cacggctcgg
    16141 gtgacggcat cctggtaggc ggcggtcgca agatcgtcgc gttctgtgtg gaaccacgcc
    16201 cagcccaggc agttctgcgt catggcggcg tcgagcggga gcccgagttc gtcgaagatc
    16261 ggcaggatgt cgatggcgac ggtggcggct tcgacagcct gaccgagcgc ggtcatgacc
    16321 aaggcgatgc cgcgattggt gatggctgcg ttgcggcggt tgccggttcg ttcgtagcag
    16381 acacgtgcga gacgcagatc gtgcagcgca tcgtcgtggt ggccccggta gtgggctacc
    16441 caggcgcggt gcgcgagcat agtgctctca ccatgaccgt cgccgagatc gcggtacagg
    16501 ccgagcgctt cgcggtagta aacggtggct tcgtcgagct tcccttggtc gaccatggcg
    16561 accccgagat tggctgtcac cgtggcgagt gcccaccggt tgtcgagcgc ggcggcggat
    16621 tcccgtgccc accggttggt tgcgatccac gcgtcccaca gcttgctggt gaagaagaag
    16681 ccgcgcagga agtatgccaa ctgccagcac cggtcgtgtt cgccgcgttt gttggcggcg
    16741 cggcacaacg ccaccaggtt cggccactcg gcctggaacc aggtgagggc catttcgtcg
    16801 tcgtccagcc tgacccgctc cgggaggtcg ggttcgaatt cgatggcggg ctggaaccgc
    16861 tgtggcgtga gcaggcgatc ggcgttggcg gtgtttcgca ccgcgtagcc ggcgagcctg
    16921 cggaaggctc ttgtgcgatc ctgttccgcc gaaccgttga gcaggtcctc gcgagcgaat
    16981 gttcgcagca ggtcgtggaa ccgatagcgc gccacgtccg gttgcacgag caggtacgtg
    17041 tcatggagcc gttccaacgc ccggtcggtt tcacgcaggc tgagcccgct caccgcactc
    17101 gcggtgtgga cgtcgaaatc gtcgccggga tgcagggcga gcagtctgaa gagctgggat
    17161 tcggcggtgg tgagttgccg tacggagagc cggaacaccg cggacagggt gcgttcgccg
    17221 tcatcgagct cgtcgagccg ggtggcttcg gcgtggagcc gccggtccag ttcaccgagg
    17281 ttccaggcag gatgggcccg taggcgcgcc gcggcgatcc ggatcgccag cgggagcctg
    17341 ccgcagcact cgaccactcg cgcgacatcg tcctccggcg ggagcccggt gagcgcgctg
    17401 aacagctcga cggcagcggg tgcgggcagc acgtcgagcg agacgtgaca ggcatcgtcg
    17461 atggcgggca gtctcgacct gctggtgatc agtacccggc acttcggctc gccgggcagg
    17521 agcggccgga cctgcgccgc gctgaccgcg ttgtccagca ccagcaacat gcttcgcccg
    17581 tgcagccgag accggtacaa ggcggtgcgg tcgtcagggt ccgccgggat cagcgcggcc
    17641 gggacgccga gcactcgcag cagccgatcg tgcacggcgt cggggctcgc ggtgggttct
    17701 tcgggatcgt atccgcgcag gtccacgaag aggcagccgt cggagaattc cgcttccagc
    17761 cggtgcgcgc accggaccgc gagctcggtc ttgccgaccc cgcccattcc tgacaccacg
    17821 cagagaccgc tgtcggttcg cagggcatcg cggacgcgcc gcaactccgt gctccgaccg
    17881 gtgaaatcgg tggcgagagg gggaagtccg gaggggcggg tgtccggccg cgtgcggcgg
    17941 cgcttggggc cactgggcaa gaagccgatg agcgctcctg gtatgcccag ttccgtttca
    18001 cagagggcgg ccagcgccgc gttcggcgtc gcaagcccgg tctcgacctt gctcaggtag
    18061 cccttgctgt agtgcgtgcg ctcggcaagc caggtcaagc tgaggccagc cgcgacgcgg
    18121 tggcgccgta gctcggcgcc gaaagtcgct cgttcgctca tcagccccca tcgtcgtcgg
    18181 atgaccagta tgaccgtcct gaacgcgacg cgatactggt cgggagttgt ccgggagccg
    18241 gccggaccac tggattcggc cggcccccga cgatgtgatg tgcggtttcg ccacatgcgc
    18301 tgcctcagcc gcacgcgagg gtcagcaggg tcacgatcag cccgagcacg tgggtctgca
    18361 tgtcaccgca cctcctctcc gtgcgtccgg accacggacc ggctcttcac ctcgggcgca
    18421 ggcgttggcg cggcggcgag caggacgccc gctagcagcg ccgataccga cagccagaga
    18481 agcagtcgga ggagcaagga aaacgaacag gtgaccgtca tttcggctcc ttcggcgagc
    18541 gcgccatggc agcgctcgag caggcgagct ccgccgaggt cttccagtgt tttcgccgcg
    18601 gaatcgttgc ggctcaccaa gaatgcggtc gccggtgcgg cgaggacaac gagtttcccg
    18661 tttccactat cggcaggaaa ggaaaccgcg gggtaacgat cgcggaggtg tcgcgtgatc
    18721 gactggacat cgagatccac ggtgacgcag gattgaccac cgtgcgtgaa cctgcttggg
    18781 aggactggtg aacgtgagcg cgctggaagt ggtcgaggag ctgaagcggc tccggcgcgg
    18841 gcggggaatt gctgcccctc agctcggcga tcatgtcgga cccgcattgc gtgtggtctg
    18901 cgatatttac gaagacgagg actcggagtc gattcgggga aaggtttccg agcgtttgca
    18961 agcccttgtc acgtcgctgg cggacgatct gcgcatggcc gtactcgccg ctttcgggct
    19021 gcacgagcag gcgcggagcc tgttctacaa agaccgggtg cggtggctgg cggagaagct
    19081 cgaccgcgac gaccggacga ttcgccgtcg aatcgaccaa ggcatccagc aggtggccgc
    19141 gttggccatc gccaccgggc gctcgacgga ccttcctcac cccagccgca gctggcatac
    19201 cgaggacctg cgggtgacct tggcgctgga ccagccggta ccggaggcgt tcgagttccg
    19261 ccgggtggtc gccgacgccg acgacatcga cgagctggac ttggctctca ccttgaccac
    19321 gcccgacgcg cgggtgccgg tggacgaggc ggacctccaa gtagacgtgt tccacggcgg
    19381 gtcgttgacc cggcggatga tggaatccag tgaccgcgtc ggtctcgcgc tgcgactgcc
    19441 gtccccactg cgacgtgggg aacggcatga ggtcgcgttg cggttcaggg ccgcactgcg
    19501 gtacccgcac tacgtttgcg ttccgcggca ccccgtcgac catttcgaac tgcacgtccg
    19561 gttcgcgcgg ccgactccgg cagagatcgt gctgctggac aacgtgttcc aggacgacgc
    19621 gcgaaaccac gcggtgcggg ggccatcgtt gtcaccggac ggatccggtg aggtccacgt
    19681 cgacttccgt aagctggcgc ccggcttcgc ctacggcgtc cgctggcagg actgacccgg
    19741 gcgcgatcat cccgtcaacg cgcggacgag gcgtgcggcg agttcctggg cgatgcttcg
    19801 agcggaagtg cgcaggtcct cggccgcgac ggcttcgtcg gcgtcgaacc tgacctcgtg
    19861 cggttgtgcc atgggcaccg acacggaggt cgcggcggct tcgcccagct tgccgacgcg
    19921 gacgaagtcg gtcggtgtca tcccgatcgt aggcgcgatc ttgcccggca gggacaagcc
    19981 gagatccgcc agcagaccga ggtgatcggt gagctggtcg atcaggtcgt cccggtccag
    20041 cagccagccg atcgtcgccg gggtagcggg gaaccagcac gttcgctgcc cggaccggta
    20101 cacggcgagt ccggtactgc cgtcgcggtt cgacgcgtac gcccaaaccg cgtcgtgcga
    20161 cgaatcgacg gtgaggccct cggacgggga gaagagccgc cgcgaccgtc cgacggaggg
    20221 cagctcgtcg cgaagtgctt cgagctgccg gacgcgcagc cggacgggtg ggtcgaccgg
    20281 caccaggtgc agctccacca agggcggctg ggcgggaccc tgccggggga gcagctccgg
    20341 tagccagttc accggcacgg cttgggacag caccgaccac gtggcgtcgg gcatcgaacc
    20401 cggacccgtc tgtggcggta ggacgagtgg ggggccgagc ggcggacgaa cgtgacgcgg
    20461 ttggctggtg atgacgcgaa gaaggtcctc gatcccttcc ggggtgatcg agtcgacggc
    20521 ataccggtcg gcggcgttgg gttggaggaa gagcgggatc ccgctgatgt cctggcccgg
    20581 caggatcacc ggcaggatct tcaccgtcca ggcctgccgg tccccctgca ggagatcgcg
    20641 caacagggcc gcttccgact gcccgccgag gttgaggtcg ttggggccgt tgccgtcgcc
    20701 catccgccgg tagtccttcg aggcgatcac gatgacgtaa tcgcactcgg tcatgccctt
    20761 taccgcccac gcctgccaat cccgtcgccg atcgctcgcc caccggtcga gcgtgacggc
    20821 gattccgctg ttttgcagca cggtcgcgaa cttgaggacg gctcggcggt ggtcttcgtc
    20881 gtcgtgggtg taggagacga aaaccgtcgg gccggtgccg aggcgttctt cgattggcat
    20941 gggagtcccc gtcgttctcg cggtaatggc gtcgttctgg cggagaacga tagcaacgtt
    21001 catctctgtc catttgtcgc ggtggtgcgc gaaaaccgga cagaacaagg acatttcatg
    21061 gattgccctg cggacgtgat acgacccgtg acaaggttct tgccttcgtt gatcatcttc
    21121 cgttcgccga aaggacgacg atcgtgccgg atccggatag cgccgccagc cggccacggg
    21181 tgtacgtctc gtacgcgtgc gaagaatcgg atgaacacgt gtcgctggtc cgcgagttcg
    21241 ccgcgttctt gcgcaccgag gccggagtcg acgcgcattt ggatcagtgg tatgccgacg
    21301 gcaggcggga ttgggtcgcg tgggcgagcg accagttcca gcaggccgat ttcatcgtgg
    21361 tcatcgcgtc cccgggatac gggctgacga tggggatgct cgacacggcg atgctgcacg
    21421 acaagctcgg ccggagcctg ccggacgcga cgcaccagat ccttccggtg gtgctccccg
    21481 gcggctccgc cacggacatt ccccacgtgc tttcggcctt tgccgccacg cattacgtgg
    21541 tgcgcgcgtt cagtctcgac gaagtgcagg gactcctccg ggcgatccac ggctcgcctg
    21601 cgcacgcgat gccgccgctc ggggcgttcc ggccccccga cgtcgaagcc ggtccggtac
    21661 tcgtcgcgac gccgcgaagc ccgcctcgca ccggcaggca cctcggccct ggcgccgaag
    21721 tggtcatcgg agacgaccat tacctggttc acgccggcac ctacgaagag acgaccactt
    21781 cggacggtgc cgcggtgttg cgcggggcgc gagcgctgtc ggtaggcggg ccgcggccgc
    21841 aggtctggtt gaggcagctc gagatccggc aggacacgcc gatggccgag gaagccgcga
    21901 cggcgctgac atgcgaacgg acactgctcg cgtcgcctgc cggacgatgg ctcgggattc
    21961 tcgtgtctcc cgcgctcgtc agggagcccg gcttggtgac gttggtgacc ggctggccgc
    22021 tgtcgggccg gactcgcggg ccgtgcgaca cgctcgcgtc cttcgtgcca gaacgcggcg
    22081 aactcgccga tccgctccgg acaagggcaa tcctgcgcgg actcggtggc ctgtgccgga
    22141 agctcgcggc gctgcaccgg atggacgcct cgcaccggtg cctggccccg gcggcgatca
    22201 tccggctcga cgacggcgcg ctggcgctcc gcgatctcgg gctcgccacc acttcgtacg
    22261 agccaggaga aggaccggag ctgtaccggg ctccggaaca ggggaggcgc cgccgcggga
    22321 aggccggccc gtggaccgat gcctaccaga tcggcgcgat cgcgtaccac ttcgcgaccg
    22381 ggcacccgcc gccgtcgata ccggtgccgg tccgcggtct tgctccggac ctgcccccgg
    22441 cggcgacggc ggcgatcgat gccgcgctcg acgccgaacc ctcccggcgc cccggcattt
    22501 tggcgctggg cgccgctttc gacagttcgc gctgaaaacc atcccgagga ggggacccgg
    22561 tgcggtccat cacgctgccc ggcccgatcg cgctcgtgcc ggccaggtca ctcgacggca
    22621 agctccgtca gctgagggag gaattccccg gtgtcctgcc gaacggggtg acgcgagtcg
    22681 tcgacgactt caacgcgcac ccgcagggag tcgcggccac catcagcgag ccgcggaacg
    22741 ggggcgaccg cagcctggtc ttgtacaccg ccgcctacgt cgtctacctg tacgcgagcg
    22801 ggcgaggaga cgcctacacg gtggcttcga tcaaacccct ccggctagcc gatcacgacc
    22861 gcctggcgaa gggctgcctg cttgtgcgcg cgcagtggca ggcggtgttc gaacttcgcc
    22921 acgttcccgc cgggtaccag tcgcggtggg accagatcca gcgcgggtgg gccgagctga
    22981 cccggcagct cggtgacgag cgcgccgtcc ccgagctgag ccccgcgcac gccgagtacc
    23041 tcgacacggt cgac
//
