LOCUS       NZ_CP059997            30136 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5726446
            Orig. end                         :: 5756582
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..30136
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="25"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..30136
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..30136
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:20136](+)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..20136
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    complement(328..348)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 21.39"
                     /tool="antismash"
     gene            783..2507
                     /locus_tag="HUW46_RS27550"
                     /old_locus_tag="HUW46_05462"
     CDS             783..2507
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229919.1"
                     /locus_tag="HUW46_RS27550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05462"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_215541701.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 2.7e-39, bitscore:
                     134.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRSRILAAVFAVPLIGGIAAVSAPAATAQPQLSGATTEFTVLAA
                     EGQSSAAAEQAIKDAGGTVVHTNTAVGLITATAPANGFTERVSANRAVFGAAKAKAIGQ
                     APKDRQVTKPDTVEKESARSGGSTAKQAKPVGLDPLDDKLWGLKSTRSDLARTKQAGDK
                     RVKVGIIDTGVDGSHPDIAPNFDAADSRNFVKDIPTDENGAVVDGPCEYRGCVDPADHD
                     DNGHGSHVAGTIAAAANGFGVSGVAPNVTLVNIRAGQDSGNFFLQPTVDALTYAGDAGI
                     DVVNMSYYVDPWLYNCKANAADSPAQQLEQRTIIEAVSRALNYAHRKGVTEIAALGNEH
                     SDLGKPPADATSPNYPSNSTHPRQIDNGSCFSLPVEGPHVLGIGSFGPSQAKADYSNYG
                     TEQISVSAPGGYARDYFGTDQFNVNENKILSVYPKNVAIAKGDVDAAGNVTPQGAKLGV
                     QKAVANDGRVGYYQYLQGTSMATPHAVGVAALIVSQYGKASRGGFGLAPDAVQRVLEGT
                     ASKVACPTPRTVDYLKEGRDASFTATCEGTPDFNGFYGHGAVDAWSAVTHGAPFVRG"
     gene            complement(2561..3181)
                     /locus_tag="HUW46_RS27555"
                     /old_locus_tag="HUW46_05463"
     CDS             complement(2561..3181)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337614.1"
                     /locus_tag="HUW46_RS27555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05463"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_215541702.1"
                     /transl_table=11
                     /translation="MTLSRAKVLDAALALADAEGLPSLSMRKLAAELGVEAMSLYNHVA
                     NKGDLLDGLAARVFESVELPDPALPWEERLRALGTGAAAAFAAHPAAIRAMAAGEANPR
                     SPGALRLIDAFLSALLDAGLDERGAAKTYRTLIGLLFGSALRDTVDVAKSPKRTEQVDD
                     WFRRVVTEDELPSLYRALPALMDASCAPEFADELGLLIENLKR"
     gene            complement(3205..4182)
                     /locus_tag="HUW46_RS27560"
                     /old_locus_tag="HUW46_05464"
     CDS             complement(3205..4182)
                     /GO_process="GO:0015891 - siderophore transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005149871.1"
                     /locus_tag="HUW46_RS27560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05464"
                     /product="iron-siderophore ABC transporter
                     substrate-binding protein"
                     /protein_id="WP_215550147.1"
                     /transl_table=11
                     /translation="MTTAACSGAQPPEKGAAPGGAYPVTIEHKYGSTTIASAPKRVVTV
                     GLTEQDSLLALGVVPVATTKWIGAFPGEIGPWASGKLGGAGVPEVLQDTSGPQFEKIAA
                     LRPDVIIGLYSGMTKESYDKLSQIAPTVAQPKEYTDFGIPWQETTKQIGRILGKQDDAA
                     KLVQGVEDRFAKVRKENPKFEGASAVMATIYDGYFVYGSQDPRSRLLTSLGFKLPADLD
                     AAIGDKFGANISAERTDLLDRDALIWVVGTAAEGQAKLASDRLYSGLKVAKEKREVFVE
                     EGTAYGHATSFVSVLSLPFQLDRLVPQLAAAVDGDPGTPVKPAS"
     misc_feature    complement(4237..4255)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 27.86"
                     /tool="antismash"
     gene            complement(4277..5761)
                     /locus_tag="HUW46_RS27565"
                     /old_locus_tag="HUW46_05465"
     CDS             complement(4277..5761)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003063317.1"
                     /locus_tag="HUW46_RS27565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05465"
                     /product="peptidase S10"
                     /protein_id="WP_215541703.1"
                     /transl_table=11
                     /translation="MSEHEEEQGETEAAEPAKAEPADDLVATQHTITVKRRKLAYTAET
                     GRVVLRKEVVTDGKFEGHQAKAEVFLTAYTLDGADPTTRPVTFAFNGGPGASSVWLHLG
                     VLGPRRVVSGDVDSPEPPPYRLADNPETLLAHSDLVFIDPVSTGYSRAATGEKPADYHG
                     FTPDIESVGEVIRLWVSRNERWLSPKFLAGESYGTLRAAALAGHLQERCGLYLNGLMLI
                     SSVLDMGTIRFHEGNDLAYSLFVPTYAAIAHYHGLHGERPLDDVLADAEEFASRELPYA
                     LAQGARLSPEARTEAVQTLASLTGLDESYVDRVNLRIEHIRFFTELLRDRGLVTGRMDG
                     RFTTWEPDGGREHMSDDPSVSRLIGAYSAAFNHYIRAELGYENDLPYQVLSLDVVRNWS
                     YSDFEGRPVTAVGTLSAAMRANPHLKLHVAFGHYDGATPYFAAEHVLAALAIPEELREN
                     IESAYYPAGHMMYAHEPSRIQQSKDLAAFVQSASNR"
     gene            5783..6490
                     /locus_tag="HUW46_RS27570"
                     /old_locus_tag="HUW46_05466"
     CDS             5783..6490
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419386.1"
                     /locus_tag="HUW46_RS27570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05466"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_215541704.1"
                     /transl_table=11
                     /translation="MRVVPQRRLRSLAELDEAVTTCRACPRLVEWRERVAREKRAAFAG
                     ETYWGRPVPGFGPHDASLGIVGLAPAAHGANRTGRMFTGDRSGDVLYQALYDVGLASQP
                     TAVAIGDGLTLRGTRIMSPVRCAPPQNKPTPEERDRCRPWLAHELEFLRPTLRAIVVLG
                     AFGWQALLPVLADAGWPVPRPRPAFGHGAHVLLGDLHLFGCFHVSQRNTQTGKLTPAML
                     RDVLVDAAGTAGL"
     gene            6670..7995
                     /locus_tag="HUW46_RS27575"
                     /old_locus_tag="HUW46_05467"
     CDS             6670..7995
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229915.1"
                     /locus_tag="HUW46_RS27575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05467"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_215541705.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 5.3e-47, bitscore:
                     159.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAAKSEPTRILVLGGGYVGLYTAFGLQKMLRANEASVTVVDPQP
                     HMTYQPFLPEAAAGAIEPRHVVVPLRRVLKRCHVLTARVTKIEHERKSVTVEAADGHVE
                     ALNYDVLVVALGAVARILPIPGLAEQGIAFKTIGEAIYLRNHVMTKLDEAASTLDPELR
                     KRLLTFTVVGGGFAGIEALAELEDMTRFATQYYENINPEDIRWVLVEAAGRILPEVRET
                     LGVYTVEQLEKRGIEVYLSTAAKSFENGHVVLSDGTEFDTDTIIWTAGVKANPVLANSD
                     LPLDKRGRLQATAALQVVGNPDVWTAGDIAAVPDLSRTEADPTATCPPNAQHAVRQARH
                     LAKNIIKSIRGGQPKDYFHKNLGAVASLGLHKGVADALNLKIKGFPAWLFHRAYHVKAM
                     PTFNRKVRIVFDWMLGGLFRREVVSLGQINNPKEEFTRATKS"
     tRNA            8040..8113
                     /anticodon=(pos:5734520..5734522,aa:Leu,seq:taa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS27580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_05468"
                     /product="tRNA-Leu"
     gene            8040..8113
                     /locus_tag="HUW46_RS27580"
                     /old_locus_tag="HUW46_05468"
     gene            complement(8201..9262)
                     /locus_tag="HUW46_RS27585"
                     /old_locus_tag="HUW46_05469"
     CDS             complement(8201..9262)
                     /codon_start=1
                     /gene_functions="regulatory (extras) StrR_like: StrR-like
                     pathway specfic regulators"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636716.1"
                     /locus_tag="HUW46_RS27585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05469"
                     /product="ParB/RepB/Spo0J family partition protein"
                     /protein_id="WP_215541706.1"
                     /transl_table=11
                     /translation="MSEPKAETADPEERAVNRLPGFSRGAGLDAPERVPITALRPADSP
                     RLSGEVPDHVTALSESVIELPPIVVHRPTMRVVDGMHRLRAAGLRGDTEISVRYFDGTE
                     EAAFLLAVTLNIEHGLPLSLADREAAASRVIEAHAHWSNRRIALAVGLSDKTIATIRKR
                     APAGTGDTARRIGKDGRARPLNSAEGRKRAGDLFAANPDLTIREVSALAGISVGTTADV
                     LKRLRLGKDPVPPKQRGEPGAAEPAPEASDRLAHLTSSLRVLRADPSLRYSDQGRALLR
                     RLEAQAMGPEQWNELAASVPQHCRDAVVDLAHACAAVWGEFAERLTADRPRPDTRVRQR
                     AKPAGVKGYPNSA"
     misc_feature    complement(9317..9328)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.96"
                     /tool="antismash"
     misc_feature    complement(9474..9487)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    9861..9876
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.74"
                     /tool="antismash"
     misc_feature    complement(9864..9879)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.3"
                     /tool="antismash"
     gene            10001..11233
                     /locus_tag="HUW46_RS27590"
                     /old_locus_tag="HUW46_05470"
     CDS             10001..11233
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="HUW46_RS27590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05470"
                     /product="YcaO-like family protein"
                     /protein_id="WP_215541707.1"
                     /sec_met_domain="TIGR03604 (E-value: 5.8e-102, bitscore:
                     340.4, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 5.3e-60, bitscore: 203.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSIYTGAIGDPGAAVPTQTGWVHNASSGNFDGAGGALDPDLAAH
                     LAVAESLERYSSCVWDPAELVWASAAELGEDAIPPSVWPNCSARELADPKCGLVAYDPR
                     IPLRWVRGWSLTRGKAVFVPAAQVYLKFSPQSASERYQHAVSTGCAAHGNALDAVTNGL
                     LEVVERDSIALTWLQRLRLPRLEFDENDLPDEYREYFERGRSENIRTLFFDATSDLGIP
                     VIYGVQLADHDPDLSQLVAATCDVDPAKAVAKLQREAASLRIALRSFTKATGEAVPADP
                     QDTVSVIGGALLNGPRANRDKFDFLLDGDRPVRRLADLPALEPGEQPLPWLLDRMHRAG
                     HEVVVVDLTTDEARQCGATVVRVLVPQAMPLSFAHRARYLAHPRLYSAPAAMGHPVRGE
                     DDINPDPQPFA"
     gene            11250..11906
                     /locus_tag="HUW46_RS27595"
                     /old_locus_tag="HUW46_05471"
     CDS             11250..11906
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03882.1"
                     /locus_tag="HUW46_RS27595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05471"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_215541708.1"
                     /transl_table=11
                     /translation="MSSTDSSVDAKQILVLTKGAFGDAVGARLSELLPVTVRDVAEGTH
                     PGLWPYTELVVLATSHERPRLAEAVDEAAFRLGAAWFPVRHGATDLQCGPVVVPGRTAC
                     HKCYLARRNQHRRVAGPEHDPDRAQPTGFPRHHVGIATGFALQAIDEVFAGPGPNRLGA
                     TVRRFDQVVGTVSRSSVVAVDRCTRCRKSGGSRSEELFEQLAPLSAGSKDLGRAI"
     gene            11903..13546
                     /locus_tag="HUW46_RS27600"
                     /old_locus_tag="HUW46_05472"
     CDS             11903..13546
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS27600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_05472"
                     /product="hypothetical protein"
                     /protein_id="WP_215541709.1"
                     /transl_table=11
                     /translation="MNGPSVITAESIGTAAKFDPQLRVPERPRVRRGLVIHPEPDEVVV
                     EGGPKRQLFRGRSATALLPSLLDRLDGRAGHETIAADLEVSEDVAFKALSLLWACGVIE
                     EGPPEELPVREVEPELVDYLSRIGDSTGANASWEQAVTRLESVRLEIFGASALAEALVA
                     ELAPAVDARTADGSLPRPDTTVVVWIDAAGVSADETIRHCWDKGIPLVRFRIDGRTADL
                     GPVADPRTTPCLYCLASGNTSDDRVARDGDVELATALFARDLFAMLSRSTPSPLPLRSR
                     RVDLDDLSQCEVSAATRPGCELCSVADGPVASEAALPTRYEASVAMPPKEFADLKAHQM
                     HYKPSNLALQRQSRTWPVAPKSDLPAPSFELLAPDWEPTKATVDGKTSDVDAELLSLVL
                     MTTVGIKGVTEQKVLRWTASGGNIGSVIAYVVVRSCAGVEPGIYGYVSSTHQLARLSTR
                     IGAVPGDAPVTVVLGGDYGKVAEKYSAFALRIVFLDSGCAQATAREVCGLLGIGFRQRP
                     DFDDRLLADAIGFDPAVEPITAVLDLGGAQ"
     gene            13543..14271
                     /locus_tag="HUW46_RS27605"
                     /old_locus_tag="HUW46_05473"
     CDS             13543..14271
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="HUW46_RS27605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05473"
                     /product="nitroreductase family protein"
                     /protein_id="WP_215541710.1"
                     /sec_met_domain="PF00881 (E-value: 5.4e-06, bitscore: 25.7,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSPIDLATQVLAELTEDRPAGGGSVARTTTEPAALGSTVVVNAE
                     PRARSSFLDALRHRSSQRFFARESVGAAHIADLVGRGLDADRAAWPGEQAAGALGVSVV
                     AFRVDGLEPGIYRLDSAARSYTRVAPLPTGEARYSLTLQAEFCESAAIVSLAADLDRVA
                     ASTGAHGYRMLMSRTSAAAYTMWLDAVATGLAGTVFAGFIPASVRQPLHSDGSSRHELF
                     ALALGVPIAPPEPPETPGLR"
     gene            14290..14457
                     /locus_tag="HUW46_RS27610"
                     /old_locus_tag="HUW46_05474"
     CDS             14290..14457
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033482.1"
                     /locus_tag="HUW46_RS27610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05474"
                     /product="thiocillin family RiPP"
                     /protein_id="WP_215541711.1"
                     /transl_table=11
                     /translation="MPEPDLELYALGDSLEFETLSDGNALASVSTGGSVSTASCPATSA
                     SSFASFSTAT"
     gene            14472..14654
                     /locus_tag="HUW46_RS27615"
                     /old_locus_tag="HUW46_05475"
     CDS             14472..14654
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033482.1"
                     /locus_tag="HUW46_RS27615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05475"
                     /product="thiocillin family RiPP"
                     /protein_id="WP_215541712.1"
                     /transl_table=11
                     /translation="MHDVYSLDLHAVDLFDDGPLIETLPEGNALSTYSTAGTLGTASCP
                     VSSAGSVLTANCQSG"
     gene            14680..14850
                     /locus_tag="HUW46_RS27620"
                     /old_locus_tag="HUW46_05476"
     CDS             14680..14850
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033482.1"
                     /locus_tag="HUW46_RS27620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05476"
                     /product="thiocillin family RiPP"
                     /protein_id="WP_215541713.1"
                     /transl_table=11
                     /translation="MSLPNGIDLYVLDEELAIEELPEGNALGSWFCAASASTASCPGSS
                     AATVGTSSTFG"
     gene            14892..15056
                     /locus_tag="HUW46_RS27625"
                     /old_locus_tag="HUW46_05477"
     CDS             14892..15056
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033482.1"
                     /locus_tag="HUW46_RS27625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05477"
                     /product="thiocillin family RiPP"
                     /protein_id="WP_215541714.1"
                     /transl_table=11
                     /translation="MSDTFELFALEGELAVEELPEGNALSSSSSASTVSSIACPLTSAG
                     TASSLSCLG"
     CDS_motif       14892..14972
                     /prepeptide="leader"
                     /note="peptide class: thiopeptide"
                     /note="predicted sequence: MSDTFELFALEGELAVEELPEGNALSS"
                     /locus_tag="HUW46_RS27625_thiopeptide"
                     /aSTool="thiopeptides"
                     /tool="antismash"
     CDS_motif       14973..15056
                     /prepeptide="core"
                     /locus_tag="HUW46_RS27625_thiopeptide"
                     /peptide="thiopeptide"
                     /predicted_class="Type III"
                     /score="0.00"
                     /molecular_weight="2445.7"
                     /monoisotopic_mass="2444.1"
                     /core_sequence="SSSASTVSSIACPLTSAGTASSLSCLG"
                     /aSTool="thiopeptides"
                     /tool="antismash"
                     /leader_sequence="MSDTFELFALEGELAVEELPEGNALSS"
                     /leader_location="[14891:14972](+)"
                     /alternative_weights="2463.7"
                     /alternative_weights="2481.7"
                     /alternative_weights="2499.7"
                     /alternative_weights="2517.8"
                     /alternative_weights="2535.8"
                     /alternative_weights="2553.8"
                     /alternative_weights="2571.8"
                     /alternative_weights="2589.8"
                     /alternative_weights="2607.9"
                     /alternative_weights="2625.9"
                     /alternative_weights="2643.9"
                     /alternative_weights="2661.9"
                     /alternative_weights="2679.9"
     gene            15130..15318
                     /locus_tag="HUW46_RS27630"
                     /old_locus_tag="HUW46_05478"
     CDS             15130..15318
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033482.1"
                     /locus_tag="HUW46_RS27630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05478"
                     /product="thiocillin family RiPP"
                     /protein_id="WP_215541715.1"
                     /transl_table=11
                     /translation="MSNTVSVVRAEIDLYALDGELGVEPLPEGSALGSFSTLTSALTMS
                     CPGSSASSVTSASSASG"
     gene            15370..15552
                     /locus_tag="HUW46_RS27635"
                     /old_locus_tag="HUW46_05479"
     CDS             15370..15552
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033482.1"
                     /locus_tag="HUW46_RS27635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05479"
                     /product="thiocillin family RiPP"
                     /protein_id="WP_215541716.1"
                     /transl_table=11
                     /translation="MIDELSSAAFELYAVDGEMALEELPDGNALGSFSSATSAGSFSCP
                     VSSASSVTTASSASG"
     gene            15723..16820
                     /locus_tag="HUW46_RS27640"
                     /old_locus_tag="HUW46_05480"
     CDS             15723..16820
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS27640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_05480"
                     /product="hypothetical protein"
                     /protein_id="WP_215541717.1"
                     /transl_table=11
                     /translation="MNTAAPKLREELELLRGMDDTPLIFDPVTGHYHRISPAAEVIVKH
                     LDGSRTKADLVDFLSGGQSTRSAALERNLDPFLATLDKSGLLVGSALPDGKRSSDRTRS
                     SMLMPRVVLTRSLPKLLEPVARVLRVLPVKYLAILLGLVSLAGYGYGMYALFGGTPPIA
                     YVYVPAFLTATAVQLLVVLVHELSHAVVAQVLKVPVRGLGVALLFYFMPVAYVDRTDAY
                     RLPGRGGRVALALAGITSDGIVCGLTGLTALTSTGFVQLSAIFLLSLQLLGLIVNINPL
                     LPSDGYSAVEAATGLVDPRGRAFTVLKSVVRGRALPPYLASISRGAKASYFAYGVVCVA
                     YGCVLFAGVLYTLFTIARLLFGLGA"
     gene            16817..19291
                     /locus_tag="HUW46_RS27645"
                     /old_locus_tag="HUW46_05481"
     CDS             16817..19291
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS27645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_05481"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_215541718.1"
                     /transl_table=11
                     /translation="MTAITTAPASADPLLPLAGPFLVRVAGLDSSALDAVVPRVAEELA
                     AVRSAERRLDTHAGPVIDVLFGLVPKLDDDVPLRREVLAGKRRVNRRAELGWGTGTRER
                     LRARISAGDVNLVAEWDELIRSRGELMAELTGALARHRASALEGLREVLRDKGFLESLA
                     IAAPDWIRYGRPHERGFDNPRELQTLYSYVARAALKTSPFSGLTTVGLGGRRGSGRSGN
                     RTSATVAYLALLRLARSETTAPLLDYRPAVIRDGGAGEPAGVLVHSELVLAEGTVWRQD
                     RVVEADHALRWISGFAGRDRVSYREVLEAVGGQRPFARFRRLLDSGVIHPVVPWRRCEA
                     PLPVLADLVRGTESEIPADDLALAHDLGARSGDGDVAARAAAGARIAKVTEGWAIRQEA
                     GGRPSGLVYEDRETDLELPDPRLFSAVGDDLSALGAKIRPKLFRSHVYDFLLERFVAEF
                     GAGGCCVDPLGFLMRQMVERDSNPGYDMATAADQRTRTGDPGERAWLPVGPTSAPPNAG
                     VMFQLEADSYEAVLAGGHRLVVNNFGAGTGGMFARFRGLLGEEFSARLAEHIARCWSGV
                     PCRELVPWTECNTAQAECAGILPPLLVPGELTTSGASTLDDTVLVHDAGTNTLSLCDRA
                     GAPFGLAYLGLVPQHLTHSYVRLLAVLADPWINASQDCDYTLDKMPQLLRRAGQDVVSL
                     PRTQLDRVVIGRASWLVPVDAIPPAVADDAAFALALREFRDRHGLPGEVFAHQLSVFPG
                     VGARKPMWISLDSPLSMRVFRQWLETGTRHVRLVEVLPSRTGHPQRDDDGRRRVTEYVT
                     LLSWPRPAGRSR"
     gene            19261..20136
                     /locus_tag="HUW46_RS27650"
                     /old_locus_tag="HUW46_05482"
     CDS             19261..20136
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF025394.4"
                     /locus_tag="HUW46_RS27650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05482"
                     /product="lantibiotic dehydratase C-terminal
                     domain-containing protein"
                     /protein_id="WP_215541719.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.8e-22, bitscore:
                     79.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAPRWEVPMMVPANTADWWYVRAYPGRVDLMDEAARVVLPWLRA
                     RADEESAVGWFFMRYLDITGLHLRLRINCDPDGVDRIHDRADELTALLHTVRGAGSGPG
                     LTGRPPVLGRTGPKKVTPCFYAPELVKYGGRPGVALAEALFSAASRWYVDNDISAVDRR
                     YERAAMAVRYLAEVVGTAMPGREREFWTAHRKQWGWQLRLEVPDQQELREVLRTTAGGI
                     AAASAIPPVSEHAAVVAGTAARAATSAVPVDPANLLLQYVHLDLNRWGFTPAEECLLGI
                     VAASSQINGK"
     misc_feature    20137..20151
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.08"
                     /tool="antismash"
     misc_feature    20138..20150
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.2"
                     /tool="antismash"
     misc_feature    complement(20165..20181)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            20215..21180
                     /locus_tag="HUW46_RS27655"
                     /old_locus_tag="HUW46_05483"
     CDS             20215..21180
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (249-285). E-value:
                     0.0023. Score: 10.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS27655_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="HUW46_RS27655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05483"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_215541720.1"
                     /transl_table=11
                     /translation="MTPEEPVVRFEEVVKRYPGPAGEVVVLDGVRLTVGRGEVFGLLGP
                     NGAGKTTSIEIMVGLRKADSGLVRVLGLDPVARRDEIRARVAIQPQQAAVFEHQTVIEL
                     LSTWASFYPEPDSPETVLAKMGLSESRDKKIAKLSGGQKQRVLVGLALVSRPRLLVLDE
                     PSTGMDPNARQELWDGLRAYRDEGGTVLLSTHSMEEAQLLCDRVAVLHRGRTVACGPPG
                     ELIREHAPDREIRFTVRADRDLSVVEPLTTAWEIAPGGEGETSVRLRTTDPDAVFAVIA
                     GTLGARRIEVTDAGLEGVFRRLTGHDFAEADDETGVRGAA"
     aSDomain        20962..21069
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS27655_PKS_Docking_Cterm.
                     1"
                     /evalue="2.30E-03"
                     /label="HUW46_RS27655_PKS_Docking_Cterm.1"
                     /locus_tag="HUW46_RS27655"
                     /protein_end="285"
                     /protein_start="249"
                     /score="10.7"
                     /tool="antismash"
                     /translation="LTTAWEIAPGGEGETSVRLRTTDPDAVFAVIAGTLG"
     gene            21180..21944
                     /locus_tag="HUW46_RS27660"
                     /old_locus_tag="HUW46_05484"
     CDS             21180..21944
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="HUW46_RS27660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05484"
                     /product="ABC transporter permease"
                     /protein_id="WP_215541721.1"
                     /transl_table=11
                     /translation="MTTLTATRALTSLHARELLRDHRYFWFALFFPYGMLGVFLLIGSV
                     LPAGGGGPDFNQIVIPMALFLAVTSAALTLTAGPLAAMRSKGTLRLLGTTPVGRARLLF
                     THMSVRVVMIICQTGVLLGIATALGAVPAANLLPLFGITVLGMALFGSIGYLIGGRLSS
                     PDAATNLGTLVQLAALFLGGLTFPLHLLPAAVGRTLGYLPTSFYADLMQTQLPTGRPMH
                     PFWLSVLVIVCTTAVFAVLAVRTFKWDQDEPR"
     gene            21981..22388
                     /locus_tag="HUW46_RS27665"
                     /old_locus_tag="HUW46_05485"
     CDS             21981..22388
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS27665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_05485"
                     /product="hypothetical protein"
                     /protein_id="WP_215541722.1"
                     /transl_table=11
                     /translation="MDKAAAEQALDTAESVSAKVLGQGRWHPGALLALGALEAAIVLTG
                     GLGQVGLLLMPGSLLPLLAFIIYTATRPVVSRHQRVRYPILGGVVALVVSVAGPLGQVK
                     FAGNPAWWVPAAVLSVIPFALAAWFEVRGRR"
     gene            22385..22675
                     /locus_tag="HUW46_RS27670"
                     /old_locus_tag="HUW46_05486"
     CDS             22385..22675
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422013.1"
                     /locus_tag="HUW46_RS27670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05486"
                     /product="transcriptional regulator"
                     /protein_id="WP_215541723.1"
                     /transl_table=11
                     /translation="MNHPRLALDPVIHSPIRFSITAALAAVDEADFKSVRDAVEISDSV
                     LSKQISTLEEAGYVTVRKIFVGKRPRTYISLTARGRKAWGTHVRALREIAG"
     gene            complement(22715..23089)
                     /locus_tag="HUW46_RS27675"
                     /old_locus_tag="HUW46_05487"
     CDS             complement(22715..23089)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037170.4"
                     /locus_tag="HUW46_RS27675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05487"
                     /product="VOC family protein"
                     /protein_id="WP_215541724.1"
                     /transl_table=11
                     /translation="MASTDSMKVGMYSFDCRDAAALAEFWAKVLMRSVDDGASAAFATI
                     GFDGDGPTWMFHQPQGDLPTGQNRLMLDLGGETDWSEQADRVEALGAERGSDNEQDGVR
                     WVVFLDPEGNTFRIFAPRPE"
     gene            complement(23164..23766)
                     /locus_tag="HUW46_RS27680"
                     /old_locus_tag="HUW46_05488"
     CDS             complement(23164..23766)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1215: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640535.1"
                     /locus_tag="HUW46_RS27680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05488"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_215541725.1"
                     /transl_table=11
                     /translation="MPRTSERGGPRTRARILEVSNRMFIEHGYDAVTVSDVAREAGVSS
                     VTVFNHFPRKEDLFLDRAAEAADLLRSAIRDREPAVDALKSLRDLCFRLADDRHPLSGL
                     ADGSAPFFRTIADSPALVAHARTLAAELHQILAEELENDAAFEGDATLLAAFFLAGYST
                     VLAETARHRIAGTAPRTVRKTHRARLERLFAALDAGG"
     gene            23853..24788
                     /locus_tag="HUW46_RS27685"
                     /old_locus_tag="HUW46_05489"
     CDS             23853..24788
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020640536.1"
                     /locus_tag="HUW46_RS27685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05489"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_215541726.1"
                     /transl_table=11
                     /translation="MSERTFPAPSTVSEQARTWLAFDGGELSYPAAEDTGAWLAMAERA
                     NQSTVHRFPISEMPVHVEDLDVDGATVYAAKPHGAGEKAVFLWLHPGGLLVGGGAACRA
                     TTAKTASSTGMLVWGVDYRLPPLHPYPAALDDAFAVYRRAVRDRDPSRVFVGGDSAGGN
                     IAAALLLRAKDAGLPMPAALVLNTPQVDLTEEGDTFQTLLGVDNVLRSLRATNALYAAG
                     ADLRDPYLSPLFGDVTGFPPTFLRSGTRDLFLSNTVRMHRKLRDAGAEAELHVFEAMPH
                     GGFGGDAPEDREAAAEQRRFLDKCGAGLRK"
     gene            24834..25847
                     /locus_tag="HUW46_RS27690"
                     /old_locus_tag="HUW46_05490"
     CDS             24834..25847
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012354.4"
                     /locus_tag="HUW46_RS27690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05490"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_215541727.1"
                     /transl_table=11
                     /translation="MELDARHLRVVCTIADAGSLTKAAARLGLSQPALTNQLRRIELVL
                     GGPLFLRTRHGAVATSLGEFVVARARPVLGVLDRLREDSIDHCGAQRPLRYIATPGPLG
                     AGLLRALEDLWTGGATLRTEADAVVAAELVADGQQDLAAVAVYVRPGFVLPAGVEDLIV
                     AEEPAFALVSGGHPAASSAEVGVTLADLRDEAWALPPASSSGLMAALAEECARAGFTAR
                     VRYEVEASVARELVAAGDAVGLGQATFYPTDNIVAVPLRDEPLRIRHRLLWRTAGAVAP
                     VMPTIARRAREAYQRAVDRSPHYLAWLARHRVPVPRQVASPATKSSPRTRDLAPQR"
     gene            complement(25906..26463)
                     /locus_tag="HUW46_RS27695"
                     /old_locus_tag="HUW46_05491"
     CDS             complement(25906..26463)
                     /EC_number="3.4.24.-"
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099822.1"
                     /locus_tag="HUW46_RS27695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05491"
                     /product="snapalysin family zinc-dependent metalloprotease"
                     /protein_id="WP_215541728.1"
                     /transl_table=11
                     /translation="MSFRKAAMAMVAALGLAVLTPALVGAPASTAAEVKVRTIYYDASQ
                     SQEFKAAVDEGAQAWNKAVPEIQLKPGSGSQATVKILADDGWPRTYPGGFGRGTVYMGR
                     EAVNDGFYPPRIAAHELGHILGLPDNRNGRCDYLMSGHSSPTSCKSTTPHATEAAQVKR
                     NAGGGFVADSIRAAELAGTFVY"
     gene            complement(26492..27205)
                     /locus_tag="HUW46_RS27700"
                     /old_locus_tag="HUW46_05492"
     CDS             complement(26492..27205)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631026.1"
                     /locus_tag="HUW46_RS27700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05492"
                     /product="trypsin-like serine protease"
                     /protein_id="WP_215541729.1"
                     /transl_table=11
                     /translation="MRRIIMVALGAIALAASGVSVAAATPSSPAQPSIIGGHNATETYS
                     FMTSLSNGCGASLVAPQWLVTAHHCGAAYQGRVGSTSKNSGGEAVRIDRNVTKPGTDLT
                     LMHLSTPARSAPVKMAQSAPAAGTPVRLLGFGCMSWPSCRNATTLQEIDLTVLASRQCA
                     PGGGTADDLCVSGDRAHSACHGDSGGPAVVGTRGDWTLAGETHGPGDNRGECATSTLYT
                     GIAAHLPWIQQQIGG"
     misc_feature    27659..27672
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.65"
                     /tool="antismash"
     gene            complement(27904..29100)
                     /locus_tag="HUW46_RS27705"
                     /old_locus_tag="HUW46_05493"
     CDS             complement(27904..29100)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013228562.1"
                     /locus_tag="HUW46_RS27705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05493"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_215541730.1"
                     /transl_table=11
                     /translation="MHHHLARVVGDRIRFYRTAAHQTKTVVAGLTGITPDYLYQIERGQ
                     KLPTIAVLAQLADVLRVELGDLLSPAPAADDKHTIAKVGATIHRALTGPLPEPTNEPKL
                     AELHHDVLDAWATWQTSPIRYSLLTARLPGLIVETEVALRVAEARDRRAAHRCAADLYG
                     LVRTVTKRIGRRDVSLLVADRAIRAAEVADDPVRLAAANWNLAQVLLADNEPEMAGATA
                     IQARESLQSRVCESTDARAVSGSLLLISAIAAVRRGNPWTARDRLREAVTLAAQVGERN
                     TCWTAFGPTNVAMYAVSVEIESGEAVEGLRLAKKIDQGRSPSIERRVAFLLDQAKGHGQ
                     RRDYAAALQLLNTAENEAPEDIRHRPSAHAVLHTVMERGRRSTAAEAARLAGEIGLPQ"
     misc_feature    complement(29121..29133)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.66"
                     /tool="antismash"
     gene            29182..29877
                     /locus_tag="HUW46_RS27710"
                     /old_locus_tag="HUW46_05494"
     CDS             29182..29877
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697071.1"
                     /locus_tag="HUW46_RS27710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_05494"
                     /product="haloacid dehalogenase-like hydrolase"
                     /protein_id="WP_215541731.1"
                     /sec_met_domain="HAD_2 (E-value: 3.9e-12, bitscore: 45.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELPEPLRTLILWDIDHTLIETRGVGRDIYERAFPAATGKPLTK
                     LASIAGRTELDIMSESLRVNGLEPTDEMVGKLAEALVRGYEDARDELASTGRALPGARD
                     ALARFAADSTVHQAVLTGNLRDVARIKLDVFGLDQYVDLASGAYGDDDASRAVLVGIAQ
                     RRAMERTGARFDNGHTVLIGDTPNDVQAALTAGVRVIAVASGKSSEAELHEAGAVEVVA
                     DLSGLAAIP"
     misc_feature    29909..29922
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.08"
                     /tool="antismash"
ORIGIN
        1 agatcgtgct gcaggacccg tacacctcgc tcaacccgag gatgaccgtc ggcgacatca
       61 tcggcgagcc gttcgagatc caccccgacg tggcgccgaa gggcgatcgg gcgaagcggg
      121 tgcaggagct gctggagacg gtgggcctga acccggacta catcaaccgg tacccgcacc
      181 agttctccgg cggccagcgc cagcgcatcg gcatcgccag ggcgctcgcg ctcaagccga
      241 aggtgatcat ctgcgacgag ccggtgtccg cgctcgacgt gtcgatccag gcacaggtga
      301 tgaacctgct cggtgatctg cagaaggaat tcggcctgtc gtatgtgttc atcgcacacg
      361 acctgtccgt tgttcgtcac ctttgcacca gggtcgcggt gatgtatctc ggaaagatcg
      421 tggagatcgg caccgaggaa gagatttaca gcaggccatc gcatccctac acacaggcac
      481 tgctgtcggc ggttccgatc gccgatcccg cggtgcgcgg aacgcggcag gtcatccggc
      541 tcgaaggcga cgtgccgagc ccgatggacc cgccgtccgg ctgccgtttc cgcacccggt
      601 gctggaaggc gcaggacatc tgcgccagcg agatcccggc gctcgacaac cgcaccgggc
      661 acctgagcgc gtgccacttc gccgaagaga aatcggtcgt tccctaactt tcgtcggata
      721 tgcctatcca tttcgggcat atgtgacgta ggttgttcgc accgtttctt caggaggagt
      781 cagtgaagag atccaggatt ctcgctgccg tgttcgcggt accgctgatc ggcggcatcg
      841 ccgccgtttc cgcgccagcc gcgaccgcgc agccgcaatt gtcgggagcc accaccgagt
      901 tcaccgtgct cgccgccgaa gggcagagct ccgccgcggc ggagcaggcg atcaaggacg
      961 cgggcggcac ggtggtgcac accaacaccg cggtcgggct gatcaccgcg accgcgccgg
     1021 ccaacggctt caccgagcgc gtctcggcga accgcgcggt gttcggcgcg gccaaggcga
     1081 aggccatcgg ccaggcgccg aaggaccgcc aggtcaccaa gccggacacg gtcgagaagg
     1141 aaagcgcccg ttccggcggc tcgacggcca agcaggcgaa gccggtcggg ctggacccgc
     1201 tcgacgacaa gctgtggggt ctcaagtcga cccgctcgga cctggcccgc accaagcagg
     1261 ccggggacaa gcgcgtcaag gtcggcatca tcgacaccgg cgtcgacggg tcgcacccgg
     1321 acatcgcgcc gaacttcgac gccgccgact cccgcaactt cgtcaaggac atcccgaccg
     1381 acgagaacgg tgccgtcgtc gacggcccgt gcgagtaccg cggctgcgtc gaccccgccg
     1441 accacgacga caacggccac ggctcgcacg tggcgggcac catcgccgcg gccgccaacg
     1501 ggttcggcgt ctccggcgtg gcgccgaatg tcacgctcgt caacatccgc gcggggcagg
     1561 actcgggcaa cttcttcctg cagcccaccg tcgacgcgct gacctacgcc ggcgacgccg
     1621 ggatcgacgt ggtcaacatg tcgtactacg tggacccgtg gctctacaac tgcaaggcga
     1681 acgcggccga cagcccggcg cagcagctgg agcagcggac catcatcgaa gccgtcagcc
     1741 gtgcgctgaa ctacgcgcac cgcaagggcg tcaccgagat cgccgcgctc ggcaacgagc
     1801 actccgacct cggcaagccg cccgcggacg cgaccagccc gaactacccg agcaacagca
     1861 cgcacccgcg ccagatcgac aacggcagct gcttctcgct gccggtcgag ggcccgcacg
     1921 tgctgggcat cggctccttc gggccgtcgc aggcgaaggc cgactactcg aactacggca
     1981 ccgagcagat ctcggtgtcg gcgccgggtg ggtacgccag ggactacttc ggcacggacc
     2041 agttcaacgt caacgagaac aagatcctgt cggtgtaccc gaagaacgtg gcgatcgcca
     2101 agggtgacgt cgacgcggcg ggcaacgtga cgccgcaggg cgccaagctc ggtgtgcaga
     2161 aggcggtcgc gaacgacggc agggtcgggt actaccagta cctgcagggc acgtcgatgg
     2221 ccacgccgca cgccgtcggt gtcgccgcgc tgatcgtttc gcagtacggc aaggcctccc
     2281 gcggcggttt cgggctcgcc cccgacgccg tgcagcgcgt gctggaaggc accgcgtcga
     2341 aggtcgcctg cccgaccccg aggacggtcg actacctgaa ggaaggccgg gacgcgtcgt
     2401 tcaccgcgac ctgtgagggc acgccggact tcaacggctt ctacggccac ggcgccgtcg
     2461 acgcctggtc cgccgtgacg cacggtgcgc cgttcgtccg cggctgatcc ccgctcgacg
     2521 tgaagcggcc cccgggttct cccgggggcc gctttcgttg ctaccgcttg aggttttcga
     2581 tcagcaggcc cagttcgtcc gcgaactcgg gcgcgcacga ggcgtccatc agcgcgggca
     2641 gcgcgcggta caggctcggc agctcgtcct cggtgaccac ccgccggaac cagtcgtcca
     2701 cctgctccgt ccttttcgga ctcttcgcca cgtcgacggt gtcgcgcagc gcggacccga
     2761 agagcaggcc gatgagcgtg cggtaggtct tcgccgcgcc ccgctcgtcc agcccggcgt
     2821 cgagcagggc cgacaggaac gcgtcgatca gccgcagcgc gccgggcgag cgcggattcg
     2881 cctcgcccgc ggccatcgcg cggatcgcgg ccgggtgcgc ggcgaacgcg gcggccgcgc
     2941 ccgtccccag cgcgcgcagc cgttcttccc acggcagtgc gggatccggc agctccacgg
     3001 actcgaacac gcgcgcggcg agaccgtcga gcagatcgcc cttgttcgcg acgtggttgt
     3061 agagcgacat cgcctcgacg cccagctcgg cggcgagctt gcgcatggac aacgacggca
     3121 ggccctccgc gtcggcgagc gcgagcgccg cgtcgagcac cttcgccctc gacaaagtca
     3181 tgcgcccagc ttacggcgta agcctcacga ggcgggtttc accggcgtgc ccgggtcgcc
     3241 gtcgaccgcg gccgcgagct gtgggacgag ccgatcgagc tggaagggca ggctgagcac
     3301 cgagacgaag gaagtcgcgt gcccgtacgc ggtgccctcc tcgacgaaca cctcgcgctt
     3361 ctccttcgcc accttcagcc cgctgtagag ccggtccgag gcgagtttcg cctgtccctc
     3421 cgcggcggtg ccgaccaccc agatcagcgc gtcgcggtcc aggagatcgg tgcgctcggc
     3481 gctgatgttc gccccgaact tgtcgccgat cgcggcgtcg aggtcggcgg gcagcttgaa
     3541 gccgagcgag gtcagcagtc gcgaacgcgg gtcctggctg ccgtagacga agtacccgtc
     3601 gtagatcgtc gccatcaccg cgctggcacc ctcgaacttc gggttttcct tgcgtacctt
     3661 ggcgaaccgg tcctcgacgc cctgcacgag cttcgccgcg tcgtcctgct tcccgaggat
     3721 gcggccgatc tgcttcgtgg tctcctgcca cgggatgccg aagtcggtgt actccttcgg
     3781 ctgcgccacc gtcggcgcga tctgggacag cttgtcgtag ctctccttcg tcatccccga
     3841 atacagcccg atgatcacgt cgggccgcag cgccgcgatc ttttcgaact gcggtccgct
     3901 ggtgtcctgc aggacctccg ggactccggc gccgcccagc ttcccgctcg cccacgggcc
     3961 gatctcgccg gggaaggcgc cgatccactt cgtcgtcgcg accggcacca cgccgagcgc
     4021 gagcagcgag tcctgttcgg tgaggccgac cgtgaccacc cgcttcggcg cgctcgcgat
     4081 cgtcgtcgag ccgtacttgt gctcgatcgt caccgggtac gccccgccgg gcgccgcccc
     4141 cttttcggga ggctgggcgc ccgagcaagc ggcggtcgtc atgagcgtgg cggcaagggc
     4201 cccggcgagg atgcggcgga tcaccccgct cactctatag gtaagcctta cctatccaaa
     4261 gggacgattt tcgcgtctac cggttcgagg cggactggac gaaggcggcc aggtccttcg
     4321 actgctgtat ccgcgaaggc tcgtgggcgt acatcatgtg gcctgccggg tagtacgccg
     4381 actcgatgtt ttccctcagt tcctccggga tggccagcgc cgccagcacg tgctcggcgg
     4441 cgaagtacgg tgtcgcgccg tcgtagtgtc cgaacgcgac gtgcagcttc aggtgcgggt
     4501 tcgcgcgcat cgccgcgctc agcgtgccca ccgcggtcac cggcctgccc tcgaagtccg
     4561 aataggacca gttacgcacg acgtcgagcg agaggacctg gtacggcagg tcgttctcgt
     4621 agccgagttc ggcacggatg tagtggttga acgccgccga gtaggcgccg atgagacgcg
     4681 acaccgaggg gtcgtcgctc atgtgctcgc ggccgccgtc gggctcccac gtggtgaacc
     4741 ggccgtccat ccggccggtg accaggccgc ggtcgcgcag cagctcggtg aagaaccgga
     4801 tgtgctcgat gcgcaggttc accctgtcca cataggactc gtcgagcccg gtgagcgagg
     4861 cgagcgtctg cacggcctcg gtgcgcgcct ccggggacag gcgcgcgccc tgcgccagcg
     4921 cgtacggcag ctcgcgcgag gcgaactcct ccgcgtcggc gagcacgtcg tcgagcgggc
     4981 gttcgccgtg caggccgtgg tagtgcgcga tcgcggcgta ggtcggcacg aacagcgagt
     5041 aggccaggtc gttgccctcg tggaagcgga tcgtccccat gtcgagcacc gacgagatga
     5101 gcatcagccc gttcaggtac agcccgcagc gctcctgcag gtgcccggcg agcgccgccg
     5161 cgcgcagcgt gccgtacgac tcaccggcga ggaacttcgg cgacagccac cgctcgttgc
     5221 gcgacaccca cagccggatc acctcgccga cggattcgat atcgggcgtg aaaccgtggt
     5281 agtcggcggg tttctcgccc gtggcagcgc gcgagtaccc cgtcgaaacg gggtcgatga
     5341 acaccaggtc gctgtgtgcg agcagggttt ccgggttgtc cgcgagccgg tacggcggcg
     5401 gctccggcga gtcgacgtca ccggaaacca cccggcgcgg cccgaggact ccgaggtgga
     5461 gccagacgct cgacgcgccg gggccgccgt tgaacgcgaa ggtcaccggg cgggtcgtcg
     5521 ggtcggcgcc gtcgagggtg taggcggtga ggaacacctc ggccttcgcc tggtgcccct
     5581 cgaacttgcc gtcggtgacg acctccttgc gcagcaccac ccggcccgtc tccgcggtgt
     5641 aggccagctt gcggcgcttc acggtgatcg tgtgctgggt ggcgaccagg tcgtcggcgg
     5701 gttccgcctt ggcgggctcg gccgcttcgg tctcgccctg ttcctcttcg tgctcactca
     5761 tgccgccaac ctacctagca caatgcgtgt cgtgccccaa cgacgcttgc gctccctcgc
     5821 cgaactcgac gaggccgtca ccacctgccg ggcttgccca cgcctcgtcg aatggcgcga
     5881 gcgcgtggca cgcgaaaagc gcgccgcctt cgcgggcgag acctactggg gacggccggt
     5941 gcccggattc ggcccgcacg acgcgtcgct cggcatcgtc ggcctcgccc ccgccgcgca
     6001 cggcgcgaac cgcaccggcc gcatgttcac cggagaccgc tccggtgatg tcctgtacca
     6061 ggcgctctac gacgtcggcc tcgcgtcgca gccgaccgcg gtggcgatcg gcgacgggct
     6121 caccctgcgc ggcacccgca tcatgtcgcc ggtgcggtgc gccccgccgc agaacaagcc
     6181 cacccccgaa gagcgggacc gctgtcgtcc ctggctcgcc catgagctgg agttcctgcg
     6241 gccgacgctg cgcgcgatcg tcgtgctggg cgccttcggc tggcaggcgc tgctgcccgt
     6301 gctcgccgac gcgggctggc cggtgccgag gccgcggccc gcgttcggcc acggcgcgca
     6361 cgtgctcctc ggcgacctgc acctgttcgg gtgcttccac gtgtcgcagc gcaacacgca
     6421 gaccggcaag ctgacccccg cgatgctgcg cgacgtgctc gtcgacgcgg cggggacggc
     6481 ggggctgtag gacctaggtc ccggcgaaga cgagaccgtt gatccctcgc gcgccggagt
     6541 ggttcgagcg gaccctggag taggaaggga ccggacctcg actgaatcgg tgccgaagtg
     6601 gcggcgacgc tggtcacagc gggatggggt ccccgagcgg taccgccaaa ggaatgggag
     6661 cataggacca tggccgcagc gaagtcggaa ccgacacgga tcttggttct cggtggtggg
     6721 tacgtcggtc tctacacggc gttcgggctc cagaagatgc tccgcgccaa cgaggcctcc
     6781 gttaccgtcg tcgaccccca gccgcacatg acgtaccagc cgttcctccc ggaggcggcc
     6841 gccggtgcga tcgagccgcg gcacgtggtg gtgccgctgc gccgcgtgct caagcggtgc
     6901 cacgtgctga ccgcgcgggt caccaagatc gagcacgagc gcaagtccgt gacggtcgag
     6961 gcggccgacg ggcacgtcga ggcgctcaac tacgacgtcc tcgtggtcgc gctcggtgcc
     7021 gtcgccagga tcctgccgat ccccggcctc gccgagcagg gcatcgcctt caagaccatc
     7081 ggcgaggcga tctacctgcg caaccacgtc atgacgaagc tggacgaggc ggccagcacg
     7141 ctcgaccccg agctgcgcaa gcgcctgctg acgttcaccg tcgtcggcgg cgggttcgcg
     7201 ggcatcgagg cgctcgccga gctcgaggac atgacccgct tcgccaccca gtactacgag
     7261 aacatcaacc ccgaggacat ccgctgggtg ctcgtcgagg ccgccgggcg gatcctgccc
     7321 gaggtgcgcg agaccctcgg cgtctacacc gtcgagcagc tcgagaagcg cggcatcgag
     7381 gtgtacctct cgacggcggc gaagtcgttc gagaacgggc acgtggtgct ctcggacggc
     7441 accgagttcg acaccgacac catcatctgg accgccggtg tcaaggcgaa cccggtgctc
     7501 gccaactcgg acctcccgct cgacaagcgc ggcaggctgc aggccaccgc ggcgctgcag
     7561 gtcgtcggca acccggacgt gtggaccgcg ggcgacatcg ccgccgtgcc ggacctttcg
     7621 cgcaccgagg ccgacccgac ggccacctgc ccgccgaacg cgcagcacgc cgtccggcag
     7681 gcgcgccacc tcgcgaagaa catcatcaag tcgatccgcg gcgggcagcc caaggactac
     7741 ttccacaaga acctcggcgc cgtcgccagc ctcggcctgc acaagggcgt cgccgacgcg
     7801 ctgaacctga agatcaaggg cttcccggcg tggctgttcc accgcgccta ccacgtcaag
     7861 gccatgccca ccttcaaccg caaggtccgc atcgtcttcg actggatgct cggcggcctc
     7921 ttccgccgcg aggtcgtgtc cctcgggcag atcaacaacc cgaaggaaga gttcacccgc
     7981 gccaccaagt cctgaccttg ccgcaccggg gcaccggtca gtcccctagg ctgaccggcg
     8041 cccccgtagc ccaactggca gaggcagtcg acttaaaatc gacaaagtgc gggttcgaat
     8101 cccgtcgggg gcactcttcc ggcgccgggc agcccgcgat tcccgacttt cggcttcgcc
     8161 gctgtgcgca ccagtcgcca gcacaccagc cgcccgctct tcaagcggag ttcggatacc
     8221 ccttgactcc agcgggtttc gcgcgctgtc gcaccctggt gtccggtcgc ggccggtcag
     8281 ccgtgagccg ttcggcgaac tcgccccaca cggcggcaca ggcatgggcc aggtccacca
     8341 ccgcgtccct gcagtgctgt gggacgctgg cggccagttc gttccactgc tcggggccca
     8401 tcgcctgcgc ctcgagccgc cgtagcagcg cgcggccttg gtcgctgtac cggagcgacg
     8461 gatcggcccg cagaacgcga aggctcgacg tgagatgcgc gagccggtcg ctggcctccg
     8521 gtgccggttc ggccgcaccc ggctcaccgc gctgcttcgg cgggaccggg tcttttccca
     8581 gccgaaggcg tttgagcacg tccgcggtgg tgcccaccga gattcccgcg agcgcggaca
     8641 cctcgcggat ggtcagatcc ggattggccg cgaagagatc ccctgcccgt ttgcggccct
     8701 cggcgctgtt cagcggtcga gccctgccgt cctttccgat tcgccgcgcc gtgtcgccgg
     8761 tcccggccgg cgcccgtttg cggatcgtgg cgatggtctt gtcggacaag ccgaccgcga
     8821 gcgcgatccg ccggttcgac cagtgcgcgt gtgcttcgat gacccgggaa gcggccgcct
     8881 ctcggtccgc cagcgacagc ggcaggccgt gctcgatgtt cagcgtcacc gccaacagga
     8941 acgcggcctc ctcggtgccg tcgaagtagc ggaccgagat ctcggtgtcg ccgcgcagac
     9001 ccgccgcccg gagccggtgc attccatcga caacccgcat cgtcggccgg tgcaccacga
     9061 tgggcggaag ctcgatcacc gattccgaca gggcagtcac gtggtccggc acctctccgg
     9121 agaggcgcgg tgaatcggct ggccgcagtg ctgtgatcgg cacgcgttcg ggtgcgtcaa
     9181 gacccgctcc ccgggagaaa cccggcaggc ggttcaccgc tcgttcctcg ggatcggccg
     9241 tttcggcctt cggctcgctc atgaactccc cagtagtgcg aagacagcac gcgtcagtta
     9301 tatgccgctc cgttgacaaa gcgatttctc tgctccgcgc gtactctgtc gcgttgaatc
     9361 atttcggctt gttcgacttc gaagggtcga agtcgaacaa gcacattggc ggcgcggggg
     9421 tggaacacgt ggtgtgcccg gcctggctcc cgggtgtcgc tcgcgttgcg gactcgatcg
     9481 gcgacaagga gttagcgcga tcgcgtgtca tgccgtggca agtgggccgt gaggcctgac
     9541 gcgacctcgg aaaaaaccgc cccaactggt cgttgttgtc gttcttgatt aacggttcgg
     9601 tgatcgttgc gactttccga cgccgcgatg tacgctcccg accagcttcc ttcaaggtgg
     9661 ttctagggga tttcgaatcg ccatcttgac ggagcgctga cgggtcgttc ctttcggcga
     9721 cccggcacgg cagttgtccc acccacgtcg gcgcggcacg gggtttcgct gtgcggaaca
     9781 cctttacatc ggtggtcgtt gccgccttgt gcgcgcagcg attccgatgc gcagcacgct
     9841 gcgcgattcg agccgcggcc aaggagaaaa attgtcgatg atgcgggtta ccgagaagac
     9901 ttccgctata ccagaaacgc ttcgagaaat gcgaaaactg gtttcgcctt tcggtctggt
     9961 gtcccggctg acgtggttgc cggtcactga gggggaaccg gtgttttcga tctacaccgg
    10021 tgccatcgga gaccccggcg cggcggtgcc gacgcaaacc gggtgggtgc acaacgcctc
    10081 gtcggggaac ttcgacggcg cgggtggcgc gctcgatccc gacctggcag cgcatctcgc
    10141 cgtcgcggag tcgctcgaga ggtactcctc gtgcgtgtgg gaccccgccg agctggtctg
    10201 ggcgagcgcg gcggaactcg gggaggacgc gatcccgccg tcggtgtggc ccaactgctc
    10261 cgcacgagaa ctggccgacc cgaaatgcgg gctggtcgcc tacgatccgc ggattccgct
    10321 gcgctgggtc cgcggctggt cgctgactag gggtaaggcg gttttcgtgc ccgcggcgca
    10381 ggtgtacttg aagttcagcc cgcaatccgc gagcgagcgg taccagcacg ccgtgtccac
    10441 cgggtgcgcg gcgcacggga acgcgctcga cgcggtgacc aacggcctgc tcgaagtggt
    10501 cgaacgggat tccatcgcgt tgacctggct gcagcggctt cgcttgccgc gcctcgagtt
    10561 cgacgagaac gatctgccgg acgagtaccg cgaatacttc gagcgaggcc ggtcggagaa
    10621 catccggacc ctgttcttcg acgcgacgag cgatctcggc atcccggtga tctacggggt
    10681 gcagcttgcc gaccacgatc ccgatctgtc ccagctcgtc gcggccacct gcgacgtcga
    10741 cccggcgaaa gcggtggcga aactgcagcg cgaggcggct tcgctccgca tcgcgctgcg
    10801 atccttcacc aaggccaccg gcgaggcggt ccccgcggac ccgcaggaca cggtcagtgt
    10861 gatcggcggc gcgctgctca acggcccgag agcgaaccgg gacaagttcg acttcctcct
    10921 cgacggcgac cgcccggtgc gccggctcgc cgacctgccc gcactggagc cgggcgaaca
    10981 gccgttgccg tggctgctcg atcggatgca ccgggccggg cacgaggtcg ttgtggtgga
    11041 cctgaccacc gacgaggcac ggcagtgcgg cgcgaccgtg gtcagagtgc tcgtaccaca
    11101 ggcgatgccg ctgtccttcg cgcaccgcgc gcgctacctc gcccatcccc ggctctactc
    11161 cgcgccggcc gcgatggggc atccggtccg cggcgaggac gacatcaacc ccgacccgca
    11221 gccgttcgcc tgagccggag gaaaaccgta tgagcagtac cgattcatcc gtcgacgcca
    11281 agcagatcct ggtgctcacg aagggcgcgt tcggcgacgc ggtcggcgcg aggctgagcg
    11341 agctcctgcc cgtgaccgtg cgggacgtgg ccgaagggac ccaccccggc ctctggccgt
    11401 acaccgagct ggtcgtgctg gcgacttcgc acgagcggcc gcggctggcc gaagcggtcg
    11461 acgaagccgc cttccggctc ggcgcggcgt ggttccccgt gcgccatggc gccaccgacc
    11521 tgcagtgcgg tccggttgtg gtgcccggcc ggaccgcctg ccacaagtgc tacctcgccc
    11581 gccggaacca gcatcggcgc gtcgccggcc cggagcacga cccggaccgc gcccagccga
    11641 ccggattccc gcggcaccac gtgggcatcg cgaccgggtt cgcgctgcag gcgatcgacg
    11701 aggtgttcgc ggggccgggc ccgaaccggc tcggcgccac cgtccggcgg ttcgatcagg
    11761 tggtcggcac cgtttcgcgg tcttcggtgg tcgcggtcga ccggtgcacc cggtgccgga
    11821 agtccggtgg gtcgcggtcc gaagagttgt tcgagcagtt ggctccgctt tcggcgggaa
    11881 gcaaggactt ggggagagcg atatgaacgg gccatcggtg atcaccgccg aatcgatcgg
    11941 caccgccgcg aagttcgacc cgcagctccg cgtgccggag cggcctcggg tacggcgcgg
    12001 gctggtgatc caccccgagc cggacgaagt ggtcgtcgaa ggcggcccga agcgccagct
    12061 tttccggggc cggtccgcga cggccctgct gccctcgctg ctcgaccggc tcgacggccg
    12121 tgccgggcac gaaaccatcg ccgccgacct ggaagtcagc gaggacgtgg ccttcaaggc
    12181 gctttccttg ctgtgggcgt gcggtgtcat cgaggaaggg cctcccgaag agctcccggt
    12241 tcgcgaggtc gagcccgagc tggtggacta cctgtccagg atcggcgatt ccaccggtgc
    12301 gaacgcctcc tgggagcagg cggtgacgcg gctggaatcg gtccggctgg agatcttcgg
    12361 cgcgtcggcg ctggccgaag cgctcgtggc cgagctcgct ccggcggtcg atgcgcgaac
    12421 ggccgacggt tccctgccgc gaccggacac caccgttgtg gtgtggatcg acgcggcagg
    12481 ggtgagcgcg gacgaaacga tccggcactg ctgggacaag ggcatcccgc tggtccggtt
    12541 ccggatcgac gggcggacgg cggatctggg cccggtggcc gatccccgca ccactccgtg
    12601 cctctactgc ctggcgtccg gaaacaccag tgatgacagg gtggcacggg atggcgatgt
    12661 cgaactcgcg acggcgttgt tcgccaggga cctgttcgcg atgctctcgc ggagcacgcc
    12721 gtcaccgttg ccgctgcggt cacgccgggt ggacctcgac gacctcagcc agtgcgaagt
    12781 ctccgccgcg acccgacccg gttgtgagct ctgctctgtc gcggacggtc ccgtcgcctc
    12841 ggaggcggct ctgcccacgc gttacgaggc ttcggtcgcg atgccgccga aggagttcgc
    12901 ggacctcaag gcgcaccaga tgcactacaa gccgtcgaac ctcgccctgc aacgccagtc
    12961 gcggacctgg ccggtggcgc cgaagtcgga cctgcccgcc ccctcgttcg agctgctcgc
    13021 tcccgattgg gagccgacaa aggccactgt ggacggtaaa acgtccgatg tggacgctga
    13081 gctgctttca ctggtgctga tgacgaccgt cggaatcaag ggcgtgaccg agcagaaggt
    13141 ccttcgctgg accgccagcg gcggcaacat cggctccgtc atcgcctacg tggtggtgcg
    13201 ctcgtgcgct ggtgtcgaac ccggcatcta cggctacgtc agctcgacgc accagctggc
    13261 gcggctttcg acccgcatcg gcgcggtgcc cggcgacgcc ccggtcaccg tggtgctcgg
    13321 tggcgactac ggcaaggtcg ccgagaagta ctcggcgttc gcgctgcgga tcgtgttcct
    13381 cgacagcggc tgcgcgcagg ccaccgcgcg ggaggtttgc ggactgctcg gcatcgggtt
    13441 ccgccagcgc cccgacttcg acgaccgcct gctggcggac gcgatcgggt tcgatcccgc
    13501 cgtcgaaccg atcaccgcgg tactcgacct cggaggagcc caatgagcag cccgatcgat
    13561 ctcgccacgc aggtgctcgc cgaactgacc gaggatcggc cggccggggg cgggagcgtg
    13621 gccagaacga cgaccgaacc ggccgcgctc ggatccaccg tcgtggtgaa cgcggaaccg
    13681 cgggcccgat cgtcgtttct cgacgctttg cgacaccgga gttcacaacg gttctttgcc
    13741 agggaatcgg tcggcgcggc gcatatcgcg gatctcgtcg gccgcgggct cgacgccgat
    13801 cgggcggcgt ggcccggcga gcaggcagcg ggcgcgctcg gggtgagcgt ggtcgcgttc
    13861 cgggtggacg ggctcgaacc ggggatctac cggttggata gcgcggcgcg aagctacacg
    13921 cgcgtcgctc cgctcccgac gggcgaggcg cgctacagcc tcactctgca agccgagttc
    13981 tgcgagtccg ccgcgatcgt ctcgctggcc gcggatctcg accgggtcgc agcgtcgacg
    14041 ggggcgcacg gttaccggat gttgatgtcc aggacctcgg ccgccgctta cacgatgtgg
    14101 ctcgacgcgg tggcaaccgg gctggccggc acggtgttcg ccgggttcat tccggcttcc
    14161 gtgcgccagc cgttgcacag cgacggcagc agcaggcacg agctcttcgc gttggctctc
    14221 ggcgtgccga tcgcgccccc ggaaccgccg gagacaccag gactccggta gcaaggagaa
    14281 aggaagtaca tgcccgaacc cgatttggaa ctctacgcgc tcggcgattc attggagttc
    14341 gaaacgcttt ccgacggcaa cgcgctggcc tcggtgtcga ccggtggctc ggtttccacc
    14401 gcctcgtgcc ccgccaccag cgccagctcg ttcgccagct tctccaccgc cacctgagag
    14461 gggtgacctc gatgcacgac gtgtactcgc tcgatctcca cgccgtcgac ctgttcgatg
    14521 acggcccgct gatcgagacg ttgcccgaag gcaacgcgct cagtacctac agcaccgcgg
    14581 gcacgctcgg cacggccagc tgcccggtca gcagcgcggg cagtgtgctg acggccaact
    14641 gccagagcgg ctgacccgtt accacgaaag gagaatccca tgtcgctccc gaacgggatc
    14701 gatctgtacg tgctcgacga agagctggcg atcgaggaac tgccggaagg caacgcactc
    14761 ggtagctggt tctgcgcggc ctcggcttcg acggcgtcct gcccgggaag ctcggcggcc
    14821 accgtcggta cttcatccac cttcggctga gctagatcag cgcagccgtg aaaatgagaa
    14881 aggaatcaac catgtcggac acgttcgaac tgttcgcgct ggaaggtgaa ctggccgtcg
    14941 aggaactgcc ggaaggcaac gccctttcgt cgtccagttc cgcgagcacg gtgtcgtcca
    15001 tcgcttgccc gcttaccagt gccggtaccg ccagcagcct cagctgcctc ggctgaggct
    15061 caccatagag ccggtgtgcc cggtcgcgcc acgaccgggc acaccgggtc ctgcggaagg
    15121 acggttgaca tgtccaacac cgtcagtgta gttcgcgccg agatcgatct ctacgccctt
    15181 gacggggagc tcggtgtcga accgttgccg gagggcagcg cgctggggtc gttttcgacg
    15241 ctgacctcgg cactgaccat gtcctgcccc ggcagctcgg cgtcgtcggt gacgtcggcg
    15301 agctcggctt ccggctgatc gacggagttc gcggaatcgc gtgctcccca ggagaaagcg
    15361 ggtgatccca tgatcgacga actgtcgtcg gcggcgttcg agctgtacgc ggtcgacggt
    15421 gagatggcgc tggaggagct tcccgatggc aatgcgctcg ggtcgttctc ctcggccacc
    15481 tcggcagggt cgttctcttg tccggtcagc tcggcgtcgt cggtgaccac ggcgtcgtcg
    15541 gcttcgggct gatcgcgcgt ccctggccgc cgtccgcggc ggccagggac gtcagcgctt
    15601 ccaggaggcc cttcgcgggt ggaatcggtg gagtgaggta acgcagatga gcactgacga
    15661 cgtgattttc ccagcggagg aatcgtgagc actgacgacg tgattttccc agcggaggaa
    15721 tcatgaacac cgcggcgccc aagctccgcg aggagctgga actccttcgg ggcatggacg
    15781 acaccccgtt gatcttcgat ccggtgaccg gccactacca ccggatttcg ccggcggccg
    15841 aggtgatcgt caagcatctc gacggttcgc gcacgaaagc ggatctcgtc gatttcctgt
    15901 ccggtggcca gtccacgagg tcggcggcgc tcgagcggaa cctcgatccg ttcctggcca
    15961 ctttggacaa gagcggcctg ctggtcggtt cggccctccc ggatgggaag cgcagctccg
    16021 accggacgcg ctcgtcgatg ctcatgccga gggtggtgct cacccggtcg ctgccgaaac
    16081 tgctggagcc cgtcgcccgc gttttgcgtg tacttccggt caagtacctc gccatcttgc
    16141 tgggcctggt ctcgctcgct ggctacgggt acgggatgta cgccctgttc ggggggaccc
    16201 cgccgatcgc ctacgtgtac gtcccggctt tccttaccgc gacggcggta cagctgctcg
    16261 tcgtgctggt ccacgagctt tcgcacgccg tcgtcgccca ggtgctgaag gtgccggtcc
    16321 gggggctcgg cgtcgcgctg ctgttctatt tcatgccggt cgcctatgtg gaccgcacgg
    16381 acgcctaccg gttgccgggc cgcggcggcc gggtcgcgct cgctctggcc gggatcacca
    16441 gcgacggcat cgtatgtggc ctgaccgggc tgaccgcgct cacctccacc gggttcgtcc
    16501 agctctccgc gatcttcctg ctgagcctgc agttgctcgg cctgatcgtg aacatcaacc
    16561 cgctgctgcc gtcggacggg tactcggccg tcgaagcggc gaccgggctc gtcgatccgc
    16621 gtggcagggc gttcaccgtg ctcaagtccg tcgtccgtgg tcgtgcactg ccgccctatc
    16681 tggcctcgat ctcccgcggg gcgaaagctt cgtacttcgc ttacggcgtc gtgtgcgtcg
    16741 cttatggctg tgtgctgttc gccggtgtcc tctacaccct gttcaccatc gcgcgcctgc
    16801 tgttcgggct gggcgcatga ccgccatcac gaccgcgccg gccagcgcgg atccgttgct
    16861 cccgctggca gggccgttcc tggtcagggt cgccgggctg gactcctctg cgctggacgc
    16921 ggtggtgccc cgggtggcgg aggagctcgc ggcggtgcgc tcggccgagc ggcggctgga
    16981 cacccacgcg ggtcccgtca tcgatgtcct tttcggactg gtcccgaagc tcgacgacga
    17041 cgtgccgctc cgcagggagg tgctcgcggg caagcggagg gtcaaccgga gagccgagct
    17101 cggctggggc accggcacgc gggaacggct tcgcgccagg atttcggccg gggacgtgaa
    17161 tctcgtggcg gagtgggacg agctcatccg ctcgcggggc gagctgatgg ccgagctgac
    17221 cggcgcgctg gcccgtcacc gggcctccgc gctggaagga cttcgagaag tactgcggga
    17281 caagggattc ctggaatcgc tcgcgatcgc ggcgccggat tggatccggt acggcagacc
    17341 gcacgagcgc gggttcgaca atccgaggga gctccagacg ctctactcct acgtcgcgcg
    17401 ggccgcgctc aagacgagcc cgttctccgg gctgaccacg gtcggcctcg gtggcaggcg
    17461 cgggtcgggg cgcagtggga accggacctc cgcgacggtc gcctacctcg cgttgctgcg
    17521 gctggcgcgg tcggaaacca ccgctccgct gctggactac cgtcccgccg tgatccgcga
    17581 cggcggcgcg ggcgagccgg ctggcgttct cgtccactcc gaactcgtgc tcgccgaagg
    17641 caccgtgtgg cgccaggacc gggtcgtgga ggccgatcac gcgctgcgct ggatctccgg
    17701 tttcgccggg cgcgaccgcg tcagctaccg cgaagtactc gaggcggtcg gcggacagcg
    17761 cccgttcgcc cggttccgca ggctgctcga ctccggggtg atccaccccg tggtgccgtg
    17821 gcgcaggtgc gaggcgccgc tcccggtgct ggcggacctg gtccggggca ccgagtcgga
    17881 aatcccggcg gacgacctcg cgctcgcgca cgacctcggg gcccggtccg gcgatggcga
    17941 tgtggccgcg agggccgcgg ccggtgcgcg gatcgcgaag gtgaccgaag ggtgggccat
    18001 ccgccaggag gcgggcggca ggccgagcgg gttggtctac gaagaccggg aaaccgatct
    18061 cgagctgccc gacccccggc tgttcagcgc ggtcggcgat gacctcagcg cgctcggcgc
    18121 gaagatcagg ccgaagctgt tccgctccca tgtctacgat ttcctgctcg aacggttcgt
    18181 ggccgagttc ggcgcgggtg gctgctgcgt ggacccgctg gggttcctga tgcggcagat
    18241 ggtggaacgc gacagcaacc ccgggtacga catggccacc gcggcggatc agcgaaccag
    18301 gacgggcgac cccggcgaac gtgcctggct gccggtcggc ccgaccagcg cgccgccgaa
    18361 cgccggcgtg atgttccagc tcgaagcgga cagctacgag gccgtgctgg ccggaggcca
    18421 ccggctggtg gtcaacaact tcggcgcggg aacgggtggc atgttcgccc gcttccgcgg
    18481 cctgctcggc gaggagttca gcgccaggct cgccgagcac atcgcgcggt gctggtccgg
    18541 cgtgccgtgc cgggagctgg tgccgtggac cgaatgcaac accgcgcagg ccgaatgcgc
    18601 cggcatcctg ccgccactgc tggtgcccgg tgagctgacc acctccggag cgtccacttt
    18661 ggacgacacc gtgctcgtgc acgacgcggg cacgaacacg ctttcgctct gcgaccgcgc
    18721 cggtgccccc ttcggcctcg cctacctcgg cctggtgccg cagcacctca cgcactcgta
    18781 cgtgcggttg ctcgccgtgc tcgcggatcc gtggatcaac gcgagccagg actgcgacta
    18841 caccctcgac aagatgccgc agctgctccg ccgtgcgggt caggacgtgg tctcgctgcc
    18901 ccgcacgcag ctggaccggg tggtgatcgg gcgggcgtcg tggctcgtcc ccgtcgacgc
    18961 gatcccgcct gccgtggccg atgacgccgc gttcgccctc gcgctccgtg agttccgcga
    19021 ccggcacggg ctccccggcg aagtgttcgc gcaccagctc tcggtgttcc ccggagtcgg
    19081 ggcgcggaaa ccgatgtgga tcagcctcga ctcgccactg tcgatgcggg tctttcgcca
    19141 gtggctggaa accgggacga ggcatgtgcg gctcgtcgaa gtgctgcctt cgcgtactgg
    19201 ccatccgcag cgcgacgacg acgggcggcg gagggtgacc gaatacgtca cgctgctgtc
    19261 gtggccgcgc cccgctggga ggtcccgatg atggttccgg cgaacacggc ggactggtgg
    19321 tacgtgcggg cgtatccggg ccgggtcgac ctgatggacg aagcggccag ggtggtgctg
    19381 ccgtggctgc gcgcgcgagc cgacgaggag tcggctgtcg gctggttctt catgcgctac
    19441 ctcgacatca ccggtttgca cctgcggctg cggatcaact gcgatcccga cggcgtcgac
    19501 cggatccacg accgcgccga cgagctgacg gcgttgttgc acaccgtccg cggcgcggga
    19561 tcgggaccag ggctcaccgg ccgccccccg gtgttgggca ggacgggacc gaagaaggtc
    19621 acgccctgct tctacgctcc cgagctcgtg aagtacggcg ggcggccggg tgtcgcactg
    19681 gccgaagcgc tgttctccgc cgcgtcgcgg tggtatgtgg acaacgacat ctccgccgtc
    19741 gaccggcggt acgagcgggc tgccatggcc gtgcgctacc tcgccgaagt ggtgggaacc
    19801 gccatgcccg gccgcgaacg ggagttctgg accgcgcacc gcaagcagtg ggggtggcag
    19861 ctccggctcg aggttccgga ccagcaggag ctccgcgaag tgttgcgcac cacggccggc
    19921 gggatcgccg ccgcgtccgc gatcccgccg gtgtcggagc acgcggcggt ggtggccggc
    19981 accgccgctc gcgccgccac cagcgccgtc ccggtcgacc cggcgaatct gctgctccaa
    20041 tacgtccacc tggatctcaa ccgctggggc ttcacccctg ccgaggaatg cctgctcggc
    20101 atcgtcgccg cctccagtca gatcaatggc aagtagtttc cattttggaa agtagatgct
    20161 agttttgcaa gtgttaggcg ggatgcttgc cgggaacggg aaggatgtgg cgtgatgacg
    20221 ccggaggagc cggtggtccg cttcgaagag gtggtcaagc gctatccggg tccagccggg
    20281 gaggtcgtcg tgctcgacgg cgtgcggctc accgtcggcc gtggcgaggt cttcggcctg
    20341 ctcggcccga acggggcggg caagaccacc agcatcgaga tcatggtggg cctgcggaag
    20401 gccgattcgg gcctggtgcg ggtactgggg ctcgacccgg tcgcgcggcg cgacgagatc
    20461 agggcgcggg tcgccatcca gccgcagcag gccgccgtgt tcgagcacca gaccgtcatc
    20521 gaactgctct ccacctgggc gtcgttctac ccggagcccg acagtccgga aacggtgctc
    20581 gccaagatgg ggctcagcga atcacgggac aagaagatcg ccaagctttc cggcggccag
    20641 aagcaacggg tactggtcgg cctcgcgctc gtttcccggc cgcgcctgct cgtgctcgac
    20701 gagccgtcga ccgggatgga tcccaatgcg cgacaggagc tgtgggacgg gttgcgcgct
    20761 taccgggacg aaggcggcac ggtgctgctt tcgacgcatt cgatggagga agcgcaattg
    20821 ctgtgcgatc gcgtcgccgt gctgcaccgc gggcggaccg tcgcctgcgg gccccccggt
    20881 gagctcatcc gcgaacacgc accggaccgg gagatccgct tcaccgtgcg ggcagaccgc
    20941 gatctgagcg tggtcgaacc gctgacgacc gcctgggaga tcgcccccgg tggtgaaggc
    21001 gagaccagcg tccggttgcg caccaccgat ccggatgccg tgttcgcggt catcgccggc
    21061 acgctcggag cgcgccgcat cgaggtgacc gacgccgggc tggagggcgt gttccgcagg
    21121 ctcacgggtc atgatttcgc cgaagcggac gacgaaaccg gcgtgcgagg agcggcctga
    21181 tgacgaccct caccgcgaca cgtgcgctga cttcgttgca cgccagggaa ctcctgcgcg
    21241 atcatcggta cttctggttc gcgctcttct tcccctacgg catgctcggc gtcttcctgc
    21301 tcatcggctc ggtgctgccg gcggggggcg gcgggcccga tttcaaccag atcgtgatcc
    21361 cgatggcgct cttcctggcc gtcaccagtg ccgcgctcac cctcacggcg ggtccgctcg
    21421 ccgcgatgcg gagcaagggc acgttgcgat tgctcggcac cacaccggtc ggcagggcgc
    21481 gcttgctgtt cacccacatg tcggtccggg tggtgatgat catctgccag accggcgtac
    21541 tgctcgggat cgccaccgcg ctcggcgccg tccccgccgc gaacctgctc ccgctgttcg
    21601 gcatcacggt gctgggcatg gcgttgttcg gcagcatcgg ctacctgatc ggcgggcggc
    21661 tgtcgtcccc tgacgccgcg accaacctcg gtacgctggt gcagctcgcg gcgttgttcc
    21721 tcggcgggct caccttcccg ctccacctcc tgcccgccgc cgtgggcagg acgctcgggt
    21781 acctgccgac ctccttctac gccgatctga tgcagactca actgccgacg ggcaggccga
    21841 tgcacccgtt ctggctttcg gtgctggtca tcgtgtgcac cacggcggtg ttcgcggtac
    21901 tggcggtccg cacattcaaa tgggatcagg acgaaccgcg ctgagttgta ggctcctggc
    21961 gtagggagga ccgtcgaaac atggacaagg cagcagcgga acaggcgctg gacaccgcgg
    22021 agtcggtttc ggcgaaagtg ctcggacagg gccgctggca cccgggagcg ctgctggcgc
    22081 tcggcgcgct cgaagccgcc atcgtgctga ccggcggtct cgggcaggtg gggctgctgc
    22141 tcatgccggg cagcctgctc ccgctcctcg ccttcatcat ctacacggcc acccgcccgg
    22201 tggtcagccg gcaccagcgc gtccgctacc cgatcctcgg cggggttgtg gcactcgtcg
    22261 tttcggtcgc gggcccgctc gggcaggtga agttcgccgg taacccggcc tggtgggtgc
    22321 ccgccgccgt actcagcgtg atcccgttcg cactggcggc ctggttcgag gtgcgaggcc
    22381 gccggtgaac cacccccggc tcgcactgga cccggtgatc cactcgccga tccggttctc
    22441 catcaccgcc gcgctcgccg ccgtcgacga ggccgatttc aaatcggtca gggacgcggt
    22501 ggaaatttcc gattcggtgc tgtccaagca gatctcgacg ctcgaagagg ctggctacgt
    22561 caccgtgcgc aagatcttcg tcggcaaacg tccgcgcacc tacatttcac tgacggcgcg
    22621 cggccgcaag gcgtggggca cccatgttcg ggccctgcgc gaaatcgccg ggtgacgggt
    22681 ccggcgatcc cgcggccaat gatcagcggc ctggtcattc cggccgtggg gcgaagatcc
    22741 ggaaggtatt gccctccggg tcgaggaaca ccacccaccg gacgccgtcc tgttcgttgt
    22801 cgctgccccg ttccgcaccc agcgcctcga cacgatcggc ttgctcggac cagtcggttt
    22861 cgccgccgag gtcgagcatc aggcggttct gcccggtggg gagatcgcct tggggttggt
    22921 ggaacatcca ggtcgggccg tcgccgtcga agccgatcgt cgcgaaggct gccgacgcgc
    22981 cgtcgtcgac ggatcgcatg agcactttcg cccagaactc cgccagtgcc gccgcgtcgc
    23041 ggcagtcgaa ggagtacatg ccgaccttca tgctgtcggt gctggccatc gtggttcctc
    23101 tctttccggg tcctgggaca ggaactgtcc tatccgatcg gccaccggcg cgccagggcc
    23161 ggatcagccg ccggcgtcca gagcggcgaa caggcgttcc aagcgcgcgc ggtgggtctt
    23221 ccggacggtt ctcggagcgg tgcccgcgat gcggtggcgg gcggtttccg ccaggacggt
    23281 gctgtagccc gcgaggaaga acgcggcgag caaggtggcg tcgccttcga aggccgcgtc
    23341 gttctccaac tcctcggcca ggatctggtg aagttcggcc gcgagggttc gcgcgtgcgc
    23401 gacgagcgcg ggggagtccg cgatcgtccg gaagaagggc gcggaaccgt cggcgagacc
    23461 ggagagcggg tgccgatcgt cggcgaggcg aaagcacagg tcccgcaagg acttcagcgc
    23521 gtccaccgct ggttcgcggt cgcggatggc cgagcgcagc agatcggccg cctcggcggc
    23581 gcggtccagg aagaggtctt ccttgcgcgg gaagtggttg aacaccgtca cactggagac
    23641 tccggcttcg cgtgcgacat cggagaccgt gacggcgtcg tacccgtgct cgatgaacat
    23701 ccggttcgag acctccagga tccgtgcgcg cgtccgcggg ccgccgcgtt cgctggttcg
    23761 gggcatgggt tccacttcct tgtgtgactt aatttagtca gttaaggtag tgttcgatcc
    23821 ggtgccaggc aaggatcgag gggagccgag tcatgagcga gcgcactttt cccgctccgt
    23881 ccacggtcag cgagcaggcg cgaacttggc tcgccttcga cggcggtgag ctgtcgtacc
    23941 cggccgccga ggacaccggt gcgtggctcg cgatggccga gcgggcgaac cagtccacgg
    24001 tgcaccggtt tccgatctcc gaaatgccgg tccacgtcga agatctcgac gtggacggcg
    24061 ccaccgtgta cgccgcgaag ccccatgggg ccggggaaaa ggcggtcttc ctctggctgc
    24121 atcccggcgg actcctggtc ggtggcgggg ccgcgtgccg cgcgacgacg gcgaagaccg
    24181 cgtcgtccac cggcatgctc gtctggggcg tggactaccg cctgccgcca ctgcacccgt
    24241 accccgccgc gctggacgac gcgttcgccg tgtaccggcg cgcggtgcgg gaccgcgatc
    24301 cctcgcgcgt tttcgtcgga ggcgactccg cgggcgggaa catcgcggcg gcccttctgc
    24361 tgcgcgccaa ggacgccgga ctgccgatgc ccgcggcgct ggtgctcaac accccgcagg
    24421 tcgatctcac cgaggagggc gacacgttcc agaccctgct cggcgtcgac aacgtccttc
    24481 gaagcctgcg cgccacgaac gccctctacg cggccggggc cgatctgcgg gacccgtacc
    24541 tctccccgct cttcggtgac gtgaccggtt tcccgccgac cttcctccgc agcggcaccc
    24601 gcgatttgtt cctttcgaac acggtccgga tgcaccgcaa gctccgcgac gccggagcgg
    24661 aggccgaact gcacgtgttc gaggccatgc cgcacggcgg tttcgggggc gacgcgccgg
    24721 aggatcggga ggccgccgcc gaacaacgcc gctttctcga caagtgcgga gctggcctac
    24781 gaaagtaggg caaaactgtc gctcaccacc gtggatacct accatcgaag ctcatggagc
    24841 tggatgctcg gcatctgaga gtggtttgca cgatcgccga cgcgggcagc ttgaccaagg
    24901 ccgcggccag actcgggttg tcgcagcccg cgctcaccaa ccagctccgg cgcatcgagc
    24961 tggtgctggg cggcccgctg ttcctccgca cccgccacgg cgcggtggcc accagcctcg
    25021 gcgagttcgt cgtggccagg gcgaggcccg tgctgggcgt gctcgaccgg ctgcgggagg
    25081 acagcatcga ccactgcgga gcccagcggc cgctgcggta catcgccacg ccggggccgc
    25141 tgggagccgg gctcctccgt gccctcgagg acttgtggac gggcggcgcc accctgcgca
    25201 ccgaggccga tgccgtcgtc gcggccgaac tggtcgccga cgggcagcag gacctcgccg
    25261 cggtggccgt ctacgtacgg ccgggtttcg tgctgcctgc cggggtggaa gatctgatcg
    25321 tcgcggagga accggcgttc gccctggtca gcggcggaca tccggccgcg agcagcgccg
    25381 aggtcggcgt cacccttgct gacttgcgcg acgaggcatg ggcgttgccc ccggcgtcga
    25441 gcagcgggct gatggccgct ttggccgagg agtgcgcgcg ggcgggtttc accgcacggg
    25501 tccgctacga agtcgaagcg agtgtggccc gagaactcgt cgcggccggg gacgcggtcg
    25561 gcctcgggca ggcgaccttc taccccacgg acaacatcgt cgcggtcccg ctgcgcgacg
    25621 aaccgctgcg catccggcac cggctgctgt ggcgcaccgc cggtgcggtc gccccggtga
    25681 tgcccacgat cgcccgccgg gcccgcgagg cgtaccagcg cgctgtcgac cgcagcccgc
    25741 actacctcgc ctggctggcc agacatcgcg tgccggtgcc ccggcaggtc gcgagccccg
    25801 cgacgaaatc ttctccccgc accagggatc tggcgccaca acgctgaaat ccgggtgtcc
    25861 ctggcccgtc ctcgacgcgc cagggacacc cggattcgct gtggctcagt acacgaaggt
    25921 gcccgcgagt tcggccgccc ggatgctgtc ggcgacgaag ccaccgcccg cgttccgctt
    25981 gacctgggcc gcctcggtgg cgtgcggtgt ggtgctcttg cacgaggtcg gcgagctgtg
    26041 cccggacatc aggtagtcgc accgcccgtt ccggttgtcg ggcagaccga ggatgtgccc
    26101 gagttcgtgc gcggcgatgc gcggcgggta gaacccgtcg ttgaccgctt cccgtcccat
    26161 gtagacggtg ccgcggccga agccgccggg ataggtcctc ggccagccgt cgtcggcgag
    26221 gatcttgacc gtggcctggc ttccggatcc cggcttgagc tggatctccg gcaccgcctt
    26281 gttccacgcc tgtgcgccct cgtcgacagc cgccttgaac tcctgcgact ggctggcgtc
    26341 gtagtagatc gtgcggacct tgacctcggc cgccgtggac gcgggcgcgc ccaccagggc
    26401 cggggtcagt accgccaggc cgagcgcggc gaccatggcc atcgcggcct tccggaacga
    26461 catcgtgcct cctctttcgg taagggcggg ctcagccgcc gatctgctgc tggatccagg
    26521 gcaggtgcgc cgcgatcccg gtgtagagcg tcgaggtcgc gcactcgccg cgattgtccc
    26581 cggggccgtg cgtttccccg gcgagggtcc agtcgccgcg cgtgccgacg accgcggggc
    26641 cgccggagtc gccgtggcac gcggaatgcg cgcggtcgcc ggaaacgcag aggtcgtccg
    26701 cggtgccgcc gcccggtgcg cactggcggc tggccagcac ggtcagatcg atctcctgga
    26761 gcgtggtggc gttgcggcag gacggccagc tcatgcaccc gaagccgagc aggcgcacgg
    26821 gcgtccccgc ggccggggcc gactgcgcca tcttcaccgg cgccgaccgc gccggcgtgg
    26881 acaggtgcat cagggtgaga tcggtaccgg gcttggtgac gttgcgatcg atccggaccg
    26941 cctcgccgcc cgagttcttg ctggtcgacc cgacccggcc ctggtaggcg gcgccgcagt
    27001 ggtgcgccgt gacgagccat tgcggcgcga cgaggctggc gccgcacccg ttgctgagcg
    27061 aggtcatgaa ggaataggtc tcggtggcgt tgtgcccgcc gatgatgctc ggctgagcgg
    27121 gactggacgg cgtggcggcc gcgacgctca caccggacgc cgcgagagcg atcgcgccga
    27181 gcgccaccat gatgattctg cgcatgggaa actcccgatc aagggtggat gaactggcct
    27241 gaatgcgttc tccgtgctcg aaaatgcgag acatcaactc cggtcggcgc tccgcgggcc
    27301 gaatgagtat cccaatgcgg atctcgtccg gccaccgtcg aaagtaggtt ttgatcaggg
    27361 atgccgcccc gtctcgatct tcgcgaactc cagagtggct cagtcggaaa tgtgcccata
    27421 gtgacatttc gccataacgc catgttatgg ctccggtgtg cacgtggtat tcggcgcggg
    27481 aaaccgatct gcccgatcgg tccgtgaaaa gcgggtaggg cggattaatc agcgcctgcc
    27541 agttcgacta cgcagttcga agtgaacagc tgggtcactc cggtgctgtc gatcagcacc
    27601 gggaacgtcg tgctgttcca ctgcccctcg tagaacgcga cggttccttc tcgtccgtgg
    27661 caccaggatt gctccgtgat tcgaacacgg gtgccaggcc ggggcctgcc atgggttcct
    27721 cgttcgtggg agtcccacca gaggctgtcg aagggttccg tatgttgcgg cctcacggcg
    27781 agccttggtc ggtgtcggca ggttcttgcc ggagggcgtg ctggtccatg gctgcccgac
    27841 cgtatggcgg ttaccggcaa gtaatccgaa ctgtccgttc gggtggtccg gcggttcggg
    27901 tcgttactgt ggcaggccga tttcgcccgc gagccgagcc gcttcggcgg cggtcgaccg
    27961 gcggcctcgt tccatgactg tgtgaaggac ggcgtgcgcg gacggacggt ggcggatgtc
    28021 ctccggtgct tcgttctctg cggtgttcag caattgcaga gctgcggcgt agtctcgccg
    28081 ctggccatgt cccttggctt gatcgaggag gaaagccacc cggcgctcga tggaaggcga
    28141 tcggccttgg tcgatcttct tcgccagtcg tagtccctcg acggcttctc ctgattcgat
    28201 ttcaacactg accgcgtaca tcgccacgtt ggtcggaccg aacgcggtcc agcaggtgtt
    28261 gcgctcgccc acttgcgcgg ccagcgttac ggcttcgcgc aaccgatcgc gagctgtcca
    28321 cgggttgccg cggcggactg cggcgatggc cgagataagc aacaacgagc cggagaccgc
    28381 cctggcatcg gtgctttcgc agacccggct ctgcaggctc tcgcgagcct gaatggctgt
    28441 cgcccctgcc atctctggct cgttgtccgc gagcagcacc tgagccaagt tccagttggc
    28501 ggccgcaagc cggacgggat cgtccgctac ttcggcggcg cggatcgctc gatcggccac
    28561 cagcagtgat acatcgcggc ggccgatgcg cttggtgacg gttcgcacca gaccgtacag
    28621 atcggcggca cagcgatgag ccgctcggcg atcgcgggcc tccgcgacgc gcaaggccac
    28681 ctcggtctcg acgatgagcc ctggtagtcg cgctgtcagc aggctgtagc gaatcggtga
    28741 ggtttgccaa gtggcccagg cgtcgagtac atcgtggtgt agttcggcca gcttcggctc
    28801 gttcgtcggc tcgggtagcg ggccagtcag cgcgcggtgg atcgtggctc cgactttcgc
    28861 gatagtgtgc ttgtcatcgg ctgctggtgc gggactgagc aggtctccga gttccacccg
    28921 gagcacgtcg gccagttgag ccagtacggc gatcgtcggt agtttctgac cgcgttcgat
    28981 ttggtacagg tagtcgggcg tgatgccggt cagcccggcc accacggtct tggtctggtg
    29041 ggcggctgtt cggtagaacc ggatccggtc gccgacgaca cgcgctagat gatggtgcat
    29101 cccgaccttc ccgtcagggt gtgacagtgg caggtagtat cgtgatcggc actgaatgtc
    29161 atcgatggca gaattcgttc catggccgag cttcctgaac cgctccgcac tctgatcctg
    29221 tgggacatcg accacaccct gatcgagacg cgcggtgtcg ggcgggatat ttacgagcgc
    29281 gcttttcccg ctgctacggg caaaccgctg accaagctgg cttcgatcgc cggtcggacc
    29341 gaactcgaca tcatgagcga atccttgcgg gtcaacggcc tcgagccgac cgatgagatg
    29401 gtcggcaagc tggctgaagc gttggtgcga ggctacgagg acgctcgcga cgagttggcc
    29461 agcaccggcc gagcgctgcc cggcgctcgc gacgccttgg cgcggttcgc ggccgattcg
    29521 accgttcacc aggctgtgct caccggaaat ctccgggatg tcgcgcgtat caagctggac
    29581 gttttcggtc tggaccagta cgtcgacctc gccagcggtg cctacggtga cgacgatgcc
    29641 agccgcgcgg ttctggttgg catcgcgcag cggcgggcga tggagcgcac tggcgcccgg
    29701 ttcgacaacg gtcacacggt gctgatcggt gacacgccga acgacgtcca agccgcgttg
    29761 accgcgggag ttcgggttat cgcggtggcg agcgggaaga gtagtgaggc cgagcttcac
    29821 gaggctggcg cggtcgaggt tgtggccgac ttgtctgggc tggctgctat tccgtgacct
    29881 tcagcaagcg actttcggcg ccaggtcgtg gaaggggtcg aagtgtgata gcgcgaccgt
    29941 gttgcgagag gtctgtttcg cggtctgtcc aggctggacg taacacaagt gggcgaatcg
    30001 gcgactaccg catcaaagtt gcgggactgg ttcatgagaa cttgcgcatc aaggaggctg
    30061 gatcgatgag taaatctgat cgtaacagcg ggaatccctg gactgaggct gagcgcgcgc
    30121 agctcgctga tctcgc
//
