LOCUS       NZ_CP059997            25335 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4743122
            Orig. end                         :: 4768457
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25335
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="20"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25335
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25335
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15335](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15335)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(239..253)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.29"
                     /tool="antismash"
     misc_feature    complement(289..307)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.73"
                     /tool="antismash"
     misc_feature    complement(1232..1244)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            1517..2584
                     /locus_tag="HUW46_RS22705"
                     /old_locus_tag="HUW46_04494"
     CDS             1517..2584
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04494"
                     /product="hypothetical protein"
                     /protein_id="WP_215549184.1"
                     /transl_table=11
                     /translation="MLVDTSAAKDDRTRTAFQNARLWGSRVELTLPGAGWGAAVARGLR
                     HAAQVGAEEVVLADPVVPADLNAPAAESRLAVALRQLREQDRPGVVCSPLAAPWWQRLL
                     AIHVLRPLCAPTLGFTLVDPQARTIVMSGDAVPDVLAPSWGLVRMGWEHGHGLGLLAAV
                     RDAGLDVGQTSPRIPHPEAFALSLNRDPVDRGEASAVLPIALRLASVAPSVRDAAPVMP
                     WVADLGLVQGQLPPPEVFTAMLTQCSRAAQVVASRPGAAAGWPESLLNSWHAARALRAD
                     IHAIAERLWLTYLARLGPWLRFGASAGGYALPARHSVAAAARQFLLATGTPVAAEQSAE
                     DLGAERIVPSVPGTG"
     gene            2643..2894
                     /locus_tag="HUW46_RS22710"
                     /old_locus_tag="HUW46_04495"
     CDS             2643..2894
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04495"
                     /product="hypothetical protein"
                     /protein_id="WP_215549185.1"
                     /transl_table=11
                     /translation="MPRRQFAADIAVDCTTVSGRDCAEVFAAAAEWLADPAQAEVQVWG
                     IDLDQPRRTDRESDANVYLELFYQRCDGNRRTMEAHGG"
     misc_feature    2949..2964
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.45"
                     /tool="antismash"
     gene            2955..3512
                     /locus_tag="HUW46_RS22715"
                     /old_locus_tag="HUW46_04496"
     CDS             2955..3512
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04496"
                     /product="hypothetical protein"
                     /protein_id="WP_215549186.1"
                     /transl_table=11
                     /translation="MRSMACTCGRIIGCSGRKTPVLKGLHGDELVYPSDGTPASEVDGT
                     REDEAAVPARVVGRRAATSHVLTYAAGQLVVTEAVVRVLGLRLPWRARLAGAVINFGTH
                     WIIDRRRFLLWLAKRVNHKDTFIAYATVMRKPDTEPDASGPGTALYDLDQRLHKALGIV
                     AAAVAARLAVPGSRRRVRGAWC"
     misc_feature    3027..3029
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3506..4156
                     /locus_tag="HUW46_RS22720"
                     /old_locus_tag="HUW46_04497"
     CDS             3506..4156
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012905.4"
                     /locus_tag="HUW46_RS22720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04497"
                     /product="HAD family hydrolase"
                     /protein_id="WP_215549187.1"
                     /sec_met_domain="HAD_2 (E-value: 0.0094, bitscore: 15.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLITTDVGHTLGSFDRPGTAEVLRDIALAPDSAAEIDRNILHVVP
                     ELTDEVAELVRERLLISPSDWPQIWPTGGFTAYPGTLAALERLAALAPVVVLSNVSCIA
                     GPARMGDLLDQCGQHLAGVYTSYQLQARKPQRRCWTTIAAEYRVPVSDIVHLGDRVPED
                     VWGALAAGCRAAVLVNTRDVHVPDDVHRDPRIAVVPDLAGAAEHVAELAGAPA"
     gene            4153..5163
                     /locus_tag="HUW46_RS22725"
                     /old_locus_tag="HUW46_04498"
     CDS             4153..5163
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.4"
                     /locus_tag="HUW46_RS22725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04498"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_215549188.1"
                     /transl_table=11
                     /translation="MSVTISPIHEEQGHYWNGQCFRSHGGCGAAVIGQGLRIRQQQQWG
                     ELPFICSCYPHISRVENAIVAEGDRAWPLDRVIAEELQRIAPYAKTALRMRRAFTSRVI
                     QCAIDEGITQFVELGSGHLHTSAARAAVIGADAGQEPTIVLVDHDPLVVAYGQGDLEDD
                     PNARHRSAMVRGNVFAVGKMLTYLAKQRLLDLDQRACVLGVDLLHFAEPEIDGRSVPQR
                     LARRLHPGSFVAITHLTDEPLLAPANADDLVALRAVTARWCRAHQRCVPPHPRPCSVEE
                     FARLVADLDLLDPGITTTRCWPEPEETRHPRAPYTLAAVGRIPERRPDASRRGAP"
     gene            5185..6579
                     /locus_tag="HUW46_RS22730"
     CDS             5185..6579
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="HUW46_RS22730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_215549189.1"
                     /transl_table=11
                     /translation="MSPTLLVGLSATLLLVIAVLALRVRARRQRQRWNNRPDSVAAITA
                     RVAAERKQPRQVWPTYDQDLRNTNPESEQPTLPLPRVQSLRPRLYLRPTSHPRASSDTL
                     DPLPCPEQSEHRNTATAPFPAARLASFATSVEHTSQLPDNRPSGEPIRAKHGVISHLEH
                     PIRMADNRSDEPTRDLAHPVSAVPVRGGLSQRHTTNPAESGQSLSPLDIQTALHDETLD
                     RAFQQRLHLAHDRDILPLVPLGYRLRVLREARGLSQRELVRRAHIGRHRVVQAEEPFTK
                     PRIPTLVHLAGPLQVDPIQLVLLAVDDFVARGPQWSALRLDLSNPYSYSFPVNENVAAI
                     LFSSAESADGQAMPLGVRLRQARVRGGITRNSLANSSRYSEELIKHVEIGLREIHTVPL
                     LVGFAVGLKVPMDQFAALIVNDIQARVIGTSITSSDNPSEPCRTGVPGHDKPALRAVTK
                     LDDTLE"
     misc_feature    5455..5457
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    5605..5607
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6205..6207
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(6668..6686)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.32"
                     /tool="antismash"
     misc_feature    6670..6679
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            6699..6866
                     /locus_tag="HUW46_RS48415"
                     /old_locus_tag="HUW46_04501"
     CDS             6699..6866
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS48415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04501"
                     /product="hypothetical protein"
                     /protein_id="WP_254126455.1"
                     /transl_table=11
                     /translation="MNKKIMSFAAGVAVSIAAALTAPVTAAVADTPPPVEPMLVGGHPA
                     ASAPAGITSL"
     misc_feature    complement(6700..6714)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            complement(6902..7126)
                     /locus_tag="HUW46_RS48420"
     CDS             complement(6902..7126)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS48420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_254126456.1"
                     /transl_table=11
                     /translation="MDHDLGHRRGFPAGEPIETADPDVECLSAVGIGAASEAKRRGMDP
                     LPPPAGGSVTRCAAVTTQPRNAAAAPQVW"
     gene            7180..>7437
                     /locus_tag="HUW46_RS48425"
                     /pseudo=""
     CDS             7180..>7437
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /locus_tag="HUW46_RS48425"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="trypsin-like serine protease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLKLDHLLQQPTLPLARETARRGGTISLYGWGGTEPDSTSADLPL
                     HLQQLDTHATAPSRCADAAMSVGELCVDNSSGTDGSCHGDS"
     gene            7685..7993
                     /locus_tag="HUW46_RS22740"
                     /old_locus_tag="HUW46_04502"
     CDS             7685..7993
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04502"
                     /product="hypothetical protein"
                     /protein_id="WP_215549190.1"
                     /transl_table=11
                     /translation="MNHSTSATANDTPRWPTPDFLRLEQPSAARIADWVAGTSHNTAVN
                     RQFGEQVAVLRLVAEIARRTLNYWLADLDPIQVDHHDGLFLHCVAARILGADVREQT"
     tRNA            8746..8818
                     /anticodon=(pos:4751901..4751903,aa:Lys,seq:ttt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS22745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_04503"
                     /product="tRNA-Lys"
     gene            8746..8818
                     /locus_tag="HUW46_RS22745"
                     /old_locus_tag="HUW46_04503"
     gene            complement(8910..9734)
                     /locus_tag="HUW46_RS22750"
                     /old_locus_tag="HUW46_04504"
     CDS             complement(8910..9734)
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF016550.4"
                     /locus_tag="HUW46_RS22750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04504"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_215549191.1"
                     /transl_table=11
                     /translation="MAHISSTHPVCPALDTTRAGLARVRDAALGGKDNYSIDRDLVAAL
                     EHAAPGFSDLVRAERAWHIRAVRYLASIGVDQFLDCGLGLPTPFDNTHEIAQRHNDEAR
                     IVYADADCIVVAHGRALLEENERSLVIQADYTYPEELVPAADAFLDFTRPIGLLLTDTL
                     HHVDDDAHPDKLMDTYRDALAPGSAIAVSHWWDPGAGPEHDAARALEATWQARCPQPGR
                     YRTRTEIEALLDGLELVPPGLVTFDDWWPDGPTMTTPTPTRRLGLAAVGIKP"
     misc_feature    complement(9672..9674)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9787..9799
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.31"
                     /tool="antismash"
     gene            complement(10001..11023)
                     /locus_tag="HUW46_RS22755"
                     /old_locus_tag="HUW46_04505"
     CDS             complement(10001..11023)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155773.1"
                     /locus_tag="HUW46_RS22755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04505"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_215549192.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7e-35, bitscore:
                     120.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPADHLTARRTLEHAIATVLAGIPLAQAATAAEMDPSALTDAVEV
                     YRDAGQRALDQHTDPGWWQVYLRFPDWDRAEHTAAQHLAPLLALAVDDGTTSGWWFVRK
                     HPCWRLRLHCGPGHWQILTETLSGAFDDLTARGHLHSWWTGIYEPETAAFGDRPGIDTA
                     HALFCADSHAILTLPHHDIGLGRRELSLLLCSTLMRAAHTEWYEQGDIWHHVARQRPLP
                     ADVTSGNVAAMAAAIRQPLLADLTEGPLLRPGGPLAPIAPWAGAFRDAGRALGTAAREG
                     HLRRGVREIISYAIIFHWNRLGFTARTQAILAHAARTAILDAHPLTPADTDAPASPVAG
                     "
     gene            complement(11005..12219)
                     /locus_tag="HUW46_RS22760"
                     /old_locus_tag="HUW46_04506"
     CDS             complement(11005..12219)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155774.1"
                     /locus_tag="HUW46_RS22760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04506"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_215549193.1"
                     /sec_met_domain="LANC_like (E-value: 1.5e-42, bitscore:
                     144.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTQQPGTLSERLAAQLAAPVIDPDDHSGREQSLSEGAAGIALL
                     HVERALASTGSWATAHAWVTAATSRGVSTAADTNLYLGASAISFLLSAAQADGRDRYQR
                     AATMLEHRVLVLARHRVETSAARASRGEATSFGEYDVFTGLTGIGRLLLQHNPDADVLE
                     QVLDYFVRLTEPRPDQLPGWWVAHDPDTTIATPGGHANLGLAHGVCGVLAFLGTALRQG
                     VTVEGHADAIARICGHLDTWRHDDDSGPWWPEWLTLDEIRTGRALQRGPLRPSWCYGTP
                     GIARAQQIAAIATGDTARQHLAEDALAACLADPGQLAHVTDTSLCHGWAGLYQTAWRAA
                     QDALTPNIAAHLPRLAASLSHADSDEPEQGSGLLTGTAGLALAAHTATHHTPPISGWDA
                     CLLIT"
     gene            complement(12216..15335)
                     /locus_tag="HUW46_RS22765"
                     /old_locus_tag="HUW46_04507"
     CDS             complement(12216..15335)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="HUW46_RS22765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04507"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_215549194.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 5.1e-195,
                     bitscore: 648.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.1e-17,
                     bitscore: 62.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKHTLFRHVDLVLARISTNPGGLDVPEFLSAGTEDAAGTGRAW
                     LARLWQRVEIRVALRIASPALAEQIDQLAAGDDGDPRQVRRVLAATSSYLLRWRRRATP
                     FGLFAGVAAASIGTSASARLDPECRVSARADARWFGEIITGLQRRHDLLPRLTVVTNNA
                     AFRRGTRVVTPARPDETQPQRGAALDTSIRHTRAVAAALDGAASPVRTAELAERIGAEF
                     PRTSPEAIARLLAQLVESGALIATLRPPLTTTEPMAHLLAELDAAGIDDLPDLVKITAE
                     LAAIRDELALARAWAPMAEHAVALEQTEERMRAVHPSPGRVQAVDVVVAGELTVPEAVL
                     REAESAATTLLRLTPFPFGDPAWKDWHARFLDRYGAGAVVGVREVVADSGLGFPAGFLG
                     AARPRAAHLVTERDVTLLRLIQRASTDNRAEIVVTESVLEDLRVGDHAKLVAPARAELA
                     FQLHAASPEALERGRFQLWVTGVPMHATSMAGRFTRLLSEQDRQRLAASYAPDRADVVC
                     AQLSFPPRRERNENIVRVPRFLPYLIPLGEHHATDPTVIALDDLAVTADADEIALVRIS
                     TGQRVQPHIPHALQNTMQTPPLARFLAEVASARRAVYGPFGYGVADGLPFVPRIRHGRT
                     VLSPARWHLTPTDVPPAAGTSSWDKALHTWQTRWHAPSAVVLVEGELRLSLDLDDPADR
                     ALLRSRLERNRTGNLELREAGPHENSGWAGRPCELVVPLRAAPPATTPGHDRTRTARPR
                     VTVRRSDTAMPGRAGIIRAHLHAHPARFDEILTDYLPALITDASTEHDALPWWFWRHHD
                     PTRADSDQHLVLCLRTRPDTDEAVTARLAGWAGTLHEAGLLAELTYASPTPSPAVLGHK
                     PETREAIDKVLTADSVAAVEQLRCAKRAWTPGQALAAASMTEIAASLATAPHLGLRDLV
                     DLLPHEPGKLDRALADAALALVDHHGQLRPLHSEQALTEAWQQRHHALAAYREHAAHDE
                     TVEERLVLRTLLRNHHLRAVSADPGTEKIIGRLTRAIAQRRLALLHQDRA"
     aSDomain        complement(14586..14867)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HUW46_RS22765_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="9.10E-20"
                     /identifier="RREFam001.1"
                     /label="HUW46_RS22765"
                     /locus_tag="HUW46_RS22765"
                     /protein_end="250"
                     /protein_start="156"
                     /score="62.2"
                     /tool="antismash"
                     /translation="TVVTNNAAFRRGTRVVTPARPDETQPQRGAALDTSIRHTRAVAAA
                     LDGAASPVRTAELAERIGAEFPRTSPEAIARLLAQLVESGALIATLRPP"
     gene            complement(15367..15537)
                     /locus_tag="HUW46_RS22770"
                     /old_locus_tag="HUW46_04508"
     CDS             complement(15367..15537)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020498823.1"
                     /locus_tag="HUW46_RS22770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04508"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_215549195.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.3e-15, bitscore:
                     54.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLALTPPAEEADEFSLDLTVIADSLPLAKMSCDTSDNCGGTTCG
                     SACTSHVATPL"
     CDS_motif       complement(15448..15537)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTLALTPPAEEADEFSLDLTVIADSLPLAK"
                     /locus_tag="HUW46_RS22770_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15367..15447)
                     /prepeptide="core"
                     /locus_tag="HUW46_RS22770_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.20"
                     /molecular_weight="2357.6"
                     /monoisotopic_mass="2356.0"
                     /core_sequence="MSCDTSDNCGGTTCGSACTSHVATPL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTLALTPPAEEADEFSLDLTVIADSLPLAK"
                     /leader_location="[15447:15537](-)"
                     /alternative_weights="2375.6"
                     /alternative_weights="2393.6"
                     /alternative_weights="2411.6"
                     /alternative_weights="2429.6"
                     /alternative_weights="2447.7"
     gene            complement(15544..16821)
                     /gene="fxlM"
                     /locus_tag="HUW46_RS22775"
                     /old_locus_tag="HUW46_04509"
     CDS             complement(15544..16821)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155777.1"
                     /locus_tag="HUW46_RS22775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04509"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_215549196.1"
                     /sec_met_domain="PCMT (E-value: 5e-41, bitscore: 139.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="Methyltransf_3 (E-value: 2.1e-05,
                     bitscore: 23.0, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTPGHTDTDAARAAGDPAELRQAMIAELWEMRAIRSDRVAAVFD
                     GVPRHLFAPEATPAEAYSPRDAVHVKRDERGVPISTVSSPQLQAGMLEQADIRPGMRVL
                     EIGSGGVNAAMMAWLAGPDGQVTTVDIDSDVTERARRLLDAAGYERVNVILADAETGIA
                     EFAPYDRIIVTVGSWDIPQAWLDQLAPDGRLVVPLRVRGLTRSLELVREGDHLVSRSAE
                     ICGFVAMQGTGAHQEQLVPLRGTDAVMRFDDGWPGEQVPDLDGVLDTPRAEAWTGVRIG
                     GAESFETLQLWLATVFPGFGKLRAEASLRSVLVDEGTVWFDSAAIDGDSVAYLTTRGVE
                     PGIAEFGAHAFGPHADDLVTAFCEQIRTWDRDQRHGPGPTFGVWPPGTPDERLPTGVVV
                     DKRHQRITTSWPSPTGQEHQEVTEKE"
     misc_feature    16914..16928
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            complement(16940..17281)
                     /locus_tag="HUW46_RS22780"
                     /old_locus_tag="HUW46_04510"
     CDS             complement(16940..17281)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04510"
                     /product="hypothetical protein"
                     /protein_id="WP_215549197.1"
                     /transl_table=11
                     /translation="MDEVLTATLQQTVVEHLNYLDVLVADGDTPSKAALAETEVARLTA
                     AWRRLLDQHAPDSRGRCARCSPRWRHNECTVWETAHQQLIGDDAPSGPDRAGRHRLRPV
                     APARQLTGG"
     gene            complement(17297..17551)
                     /locus_tag="HUW46_RS22785"
     CDS             complement(17297..17551)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215549198.1"
                     /transl_table=11
                     /translation="MAVVVARDSPIGRAAEAVDQAARHLPSPDQPYVCPCCSTDPWPCN
                     WFDDAARRLMAAGLRLAEFVPSELHERLWPQRQRRHPDE"
     misc_feature    complement(17375..17377)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17984..19159
                     /locus_tag="HUW46_RS22790"
                     /old_locus_tag="HUW46_04511"
     CDS             17984..19159
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023736.1"
                     /locus_tag="HUW46_RS22790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04511"
                     /product="XRE family transcriptional regulator"
                     /protein_id="WP_254126458.1"
                     /transl_table=11
                     /translation="MADANYIGKLERGVIRWPSALYREALRGVLGAATDGALGFTNRRR
                     TVVKLADVDRKKFLRGVGLGVGALTLAPVAARFQGSEPTPVPSRVGSAEIGQIATAAKV
                     FAGWDHTYGGGLAREAVQAQLHWSAGLLDASCHEALRGPLRSAIGYLAHTCGFMAFDAY
                     KHADATNAFEFGLACAEEAGDWHLRAKILSSMARQAIWRGYPDDGLTSIEHALVRADRL
                     TATERAMLYTAHARALAKMRRTREALAAVGRADEEFAHATPANDPPWMAYYDHAQHVGD
                     TGHALFDLAVLGYRPVDAAARLADAVTGHTDAYPRSRAISQTKLATLTMATGDPAEAAV
                     IGQAALDAAGTVRSRRAADDLRELSRYAHRHSRTPEVAALRQRIHTVLAAS"
     gene            19156..20052
                     /locus_tag="HUW46_RS22795"
                     /old_locus_tag="HUW46_04512"
     CDS             19156..20052
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155780.1"
                     /locus_tag="HUW46_RS22795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04512"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_215549200.1"
                     /sec_met_domain="APH (E-value: 7.8e-19, bitscore: 67.6,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTGTEEAEELLRAACDQAGVDARGAEPIRLGENAIFRLPGGIV
                     ARIARPGQLHAATREVRVARWLADHDVPAVRALDDLRQPIEAHGRAVTFWHELPAHHHG
                     TPAQVATALRRLHDLPVGTGQHPFSALEPFVRLDERITAATSLTDDDRAWLYQHLATLR
                     ERYDHLPAGLPRTVLHGDAWVGNVVATNDNQVVLLDLERASIGPPEWDLVSTAIKHTSF
                     AWISEHEYRDFRHRYGHDVTTWDGFALLRDIRELRMTCYMAQHAAENPRGHREAELRVS
                     CLRGRNGLRPWAWSPAS"
     gene            20182..21198
                     /locus_tag="HUW46_RS22800"
                     /old_locus_tag="HUW46_04513"
     CDS             20182..21198
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04513"
                     /product="hypothetical protein"
                     /protein_id="WP_215549201.1"
                     /transl_table=11
                     /translation="MDLADLAGEALTLLAGFAGAVGKGALDKAQNDAIQALYTAVRQRL
                     GGRRGDAAALKNLEQAPADPGRREVVTGILHDALEADPGFAAELREAVRQARVTINHDG
                     DVRAGPVAGDQAVGTIGSGSSSNTLIQNNSGSIDQSHHATTDNRRSKTTNRFGIGTTPL
                     VLIAALMIAVVTGVTTSVIVSVNNPAWFDRLFPPQDDVPDLPANVADGKPYQYLPTQPY
                     EAVRHVYELVDKNDPAACERFEENVRPVFARHFGAPDCAAAVTMLHARVTDDWAFAFSV
                     RQRDSTVHFPPTMKISSCSFPIKGGPSLGLFTLTRLDKGQWLITNHETEASPCPPVR"
     gene            complement(21409..22575)
                     /locus_tag="HUW46_RS22805"
                     /old_locus_tag="HUW46_04514"
     CDS             complement(21409..22575)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009945792.1"
                     /locus_tag="HUW46_RS22805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04514"
                     /product="hypothetical protein"
                     /protein_id="WP_254126460.1"
                     /transl_table=11
                     /translation="MTETALTDLTLSAARRRALEVRKRLARFKLVFIQCGVAFEPLREP
                     LLAQLDTTVLDAADFAKKPGLIGPGAKQVVLTGVEAFARDGTAAGTTIGTLRVQVLQLL
                     ERDIEVCLVSRVARTAFAPVVGSNLLVDAKLHCLPALGSDECPATTRDHPGFALPAIGF
                     GSDTDVATILRTALAELGVSILTELDYALFEARHNTRFISEVDAVTQETLRSAGLAHIV
                     NDEISLTAPRLLWKFKEAIGDVMASNVSPQTDLAEVSEGLWNIERTIRKTLRDAAVNEP
                     NVKNWRKSLLHETLAKTVLERARDDAHPDAASIAELRDPIEWLSLGELLELVRSKRFDG
                     LFWKKVTWDKFTQQVIPIRNRLSHMRLLKKGDKTTVRKWVNLLQQAKK"
     gene            complement(22572..24320)
                     /locus_tag="HUW46_RS22810"
                     /old_locus_tag="HUW46_04515"
     CDS             complement(22572..24320)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024793.4"
                     /locus_tag="HUW46_RS22810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04515"
                     /product="translation initiation factor IF-2 N-terminal
                     domain-containing protein"
                     /protein_id="WP_215549202.1"
                     /transl_table=11
                     /translation="MRQRVHELAKELGIGSRKVMARLAELGVHVRSASSLVEKDAATRL
                     KESFGQYDAATAAGAATPRPATWSAGAVKPLTHPEPLRRLALLKQSFPVVDDHQAILAK
                     LGSQFFYSVVGGVPGADDCGFALVRFSGAIESAFGLTREVFFFYSPHRDLQMRTFQAAK
                     RKLTSLRQHREVTPDMMFFWSPDPRLRERLDDWSKDLLAIPLDLPDDGDPIAFVKLLSS
                     YVFTRDLFYETTPVRGDRFFGRRQLLQTLRDDIRHQRVAGLFGLRKAGKTSVLSELEQT
                     LSGPETIFILRDLESLPSPPEDPVPDLLKDLVTDLVTELRQRRLTTRALTSLSATPTVS
                     DFKRAFQTVLRRLAEDGITIVLMLDEIEYLTPSDRIDIHEGDLTSVSQLLGALRSLVQE
                     NGNFTFLLSGLISAIIESGRLYGRPNPLFSWAKANFLAPFERHEADELARSVGQKMGVS
                     IDTGALDALFEATGGHAFLYRHLASKVVDQLPVDTFHREIKKPLVLRTITEWRRDVAGN
                     MREMLDHVERYYPDESYLLEVLMDEPESFTAFAEDAPLALGHLLSLGLVHKVDNAYELT
                     PVLHLL"
     misc_feature    complement(25293..25313)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 22.08"
                     /tool="antismash"
ORIGIN
        1 agtatcgaac gacgtgcagt ggagcggcac cgcgctaccg atctctatcg cgagatcaac
       61 ctcgacgtca cccagctcga ttctgtacac aaggccgttc aagatgttct cagtgtgttc
      121 ggtcgaattg acattctcgt caacaatgca ggggtgtccg acggagaaaa cgacgccttg
      181 cgcctcgatc ttgaagtgtt caaagaggta atggacgtga acctgctggg tgcatggcga
      241 ttgtctgaag cagtaatacc ggcgatgacc ataaataact acggccgtat cgttaatatg
      301 tccagcaccc ttgggtcatt gcatcacatg aatcgagcga ccgagccggt ataccggatc
      361 agcaaagccg ctataaacgc cttgacccgc gtcttcgccg cgcgcttaag cgataccgga
      421 attctcgtca acgctgcttc tccaggttgg gttaggactg acctcggcgg accgaacgcg
      481 ccacgctcgg tccagcaagg tgctgacacc ccggtctggc ttgccacgct tcccgagggt
      541 gggccgtctg gcggcctctt ctatgaccgt gcgccactcg aatggtgaac ctcggcaaag
      601 taggcccctc gatctaagat tgttcgaagc cacctcggtg atcacgtcca ttcaggcgac
      661 gggttgcttc gcaggtgaag ttggttctac gttctgcaga ccagtggacc tggactcagg
      721 tcagctggca ctaaagactc ggcctacaag cggcctacac gtttcctctt cccctcccgt
      781 ccacgaagcg caaagatcgc aatctcatta cccgatctga tcagccaaga aagcgagcaa
      841 acccggcctt ctgctacaga tgccggaccg ggcggaagct aacagcagga cacgcgatcg
      901 cgcttgtgcg acttcggtgg cacttcagcg cgacatcgtg tgcttagcct ctttcgtccc
      961 agccaggaca aggaaaatct gcttaagggg gaagagtgac ggtgcgatta cggcttggat
     1021 gcgacagaat ttggcgtgcc cgagcgtcgt gcgagggtgc cgacacagtc cacgcctccc
     1081 tctctgttcc cgttgcctcg taccgcggac accttttctg cgcaagctca ggaaggctct
     1141 ctacgcgaga gaaccacgtg gcggttgagg ctaggcgcgg aggtgcggcg gcatgtcctc
     1201 gaaaccgtca cgaatcgcag agggcagcac cgtgacggct tcacggctgc cgaggacgtc
     1261 ctcacctcgg cttggccaga tccatccccc ggggtcggcc agcgagttgg ggcgcggggc
     1321 ggcacgacca tctggcaact cgacgactcc ccaccccgcc gatggtcgcg ccgtcccatc
     1381 cagtgcgagc gaattcgaat cgccaccgct cgttattgtg ctgcctgccc gcgcgcaccc
     1441 ggacaccgtt gcggttgcgg ccgaatacgg cgaacacgcc actctgggga gcgggtcgcc
     1501 aaggtcagtg tgcaccgtgc tggtggatac cagcgccgcg aaagacgaca ggacaaggac
     1561 ggccttccag aacgcccggc tgtggggatc gcgggtcgag ttgacgttgc ctggggccgg
     1621 gtggggtgcg gcggtcgcgc gtggcttgcg tcacgcagcg caggtcgggg cggaggaggt
     1681 ggtgctggcc gaccccgtgg tgcccgcgga tctcaacgca ccggccgcgg agtcgcggct
     1741 cgcggtggcg ttgcgccaac tgcgtgagca ggatcggccg ggagtggtgt gcagcccgtt
     1801 ggccgcgccg tggtggcagc gtctgctggc aatccacgtg ctgcggccgt tgtgtgcgcc
     1861 aacgctgggt ttcacgctgg ttgacccgca ggcccgcacg atcgtgatgt ccggcgacgc
     1921 cgtacccgac gtgctcgcac cgtcctgggg gttggtgcgc atgggctggg agcacgggca
     1981 cggcctgggg ctgttggctg ccgttcgcga cgccggtctg gatgtcgggc agacctcgcc
     2041 ccgcattccg cacccggagg cgttcgccct gtcgttgaac cgggatccgg tggatcgtgg
     2101 cgaagcgtcc gccgtgctgc cgatcgcgct gcggttggcg tcggttgccc cctcggtgcg
     2161 cgacgcggcg ccggtaatgc cgtgggtggc cgatctcggg ttggtccagg gacagcttcc
     2221 gccgccggag gtgttcaccg cgatgctgac gcagtgctca cgcgcggccc aggtggtggc
     2281 gtcacggcca ggagccgccg cgggctggcc cgagtcgctg ctgaactcct ggcatgccgc
     2341 ccgggcgctg cgagctgaca ttcacgcgat cgccgaacgg ttgtggctga cctacctggc
     2401 gcggctcggg ccgtggctgc gcttcggcgc cagcgccggt ggctacgcgc tgcccgcccg
     2461 tcattcggtc gccgcggcgg cacgccagtt cttgttggcc accggaacac cggtcgcggc
     2521 cgagcagagc gcggaggacc tcggcgctga gcgcatcgtc ccgtcggttc ccggaaccgg
     2581 ctgagcgcca cgcgcgctcg ctgatcacgt tcacccgaag tatctcgaag aggaaggttc
     2641 gtatgccacg ccgacaattc gcagcggaca tcgccgtgga ctgcacgaca gtcagcggcc
     2701 gggactgcgc cgaggtgttc gccgccgcgg ccgagtggct ggccgacccc gcacaggccg
     2761 aagtccaggt ctggggcatc gacctcgacc agccccgccg caccgatcgc gaatccgacg
     2821 cgaacgtcta cctcgaactg ttctaccagc gctgcgacgg taaccgccgc accatggagg
     2881 cacacggcgg atgagcacgg ccaccttccc ggaccgcgcc gtggaacgag tagcgctgtt
     2941 cggagcgctc gcaagtgcgt tccatggcct gcacctgtgg gcggatcatt ggttgcagcg
     3001 gccgaaagac gcctgtcctc aaaggattac acggcgacga gctggtgtat cccagcgatg
     3061 gcacaccggc ttccgaagtc gacggcacgc gcgaggacga ggctgcggtg ccggcccgcg
     3121 tcgtcgggcg ccgcgcggcc acgagccatg tgctgaccta cgcggccggg cagctggtcg
     3181 tcaccgaggc cgtcgtgcgc gtcctcggcc tgcggctgcc gtggcgtgcc cggctggccg
     3241 gtgcggtgat caacttcggg acgcactgga tcatcgaccg gcgtcgtttc ctgctgtggc
     3301 tggcgaagcg ggtcaaccac aaggacacct tcatcgcgta cgcgaccgtg atgcgcaagc
     3361 ccgacaccga accggatgct tccgggccgg gcaccgcgct ctacgacctc gatcagcggc
     3421 tgcacaaggc cctgggaatc gtggccgcgg cggtggcagc gcgccttgcc gtacccgggt
     3481 cgcgtcgtcg agtgcgaggt gcctggtgct gatcaccacc gatgtgggcc acaccctcgg
     3541 ctcgttcgac cggccgggta ccgcggaggt gttgcgagac atcgcgctgg cgccggatag
     3601 cgcggccgag atcgaccgca acatcctgca tgtcgttccc gaactcactg acgaggtcgc
     3661 cgagctggtg cgcgagcggt tgctcatcag cccctccgac tggccccaga tctggccgac
     3721 tggtgggttc accgcctatc caggaacgtt ggccgctttg gaacgcctcg cggccctggc
     3781 gccggtggtc gtgttgtcga acgtctcctg catcgccggg cccgccagga tgggtgacct
     3841 tctcgaccag tgcgggcagc acctcgccgg ggtctacacc agctaccagc tgcaggcgcg
     3901 taaaccccag cgccggtgct ggaccacgat cgccgccgag tatcgggtac cggttagcga
     3961 catcgttcac ctcggcgatc gggttcctga agacgtctgg ggagcgctcg ccgccgggtg
     4021 ccgggccgct gtgctcgtca acactcgcga cgtccacgtg ccggacgacg ttcatcgtga
     4081 cccgcggatc gccgtagtgc ccgatctggc cggcgccgct gagcacgtcg ctgagctggc
     4141 aggagcaccc gcgtgagcgt gacgatctct ccgatccacg aggagcaagg acactactgg
     4201 aacggacaat gtttccgttc gcacggcgga tgcggggcgg cggttatcgg gcaaggtctc
     4261 cggattcgcc agcagcagca gtggggcgaa ctgccgttca tatgctcgtg ttatccgcat
     4321 atctcgcggg tggagaacgc gatcgtcgcc gagggcgacc gggcatggcc gctcgatcgc
     4381 gtgatcgctg aggaactgca acgcatcgcc ccctatgcga aaacagcact gcggatgcgg
     4441 cgcgctttca cttcccgggt gatccagtgc gcaatcgacg aaggcattac ccagttcgtg
     4501 gagctgggct cagggcatct gcataccagc gcggcacgcg ccgcagtgat cggcgcggat
     4561 gcaggccagg agcccacgat cgtgctcgtc gaccacgacc cgctcgtcgt cgcatacggg
     4621 cagggcgacc tcgaggacga ccccaacgct cggcaccgat cggccatggt gcggggaaac
     4681 gtcttcgctg tcggcaaaat gctcacctac ctggccaagc agagactgct cgatctcgac
     4741 cagcgcgcgt gcgtgttggg cgtcgacctc ttgcacttcg ccgaacccga gatcgacggc
     4801 cgctccgtgc cgcagcgcct ggcgcgacgc ctgcacccgg gcagctttgt cgcgatcacg
     4861 cacctgacgg acgaaccgct gctcgcgccc gcgaacgccg acgatctcgt ggctttgcgc
     4921 gcggtcaccg cccgctggtg ccgagcacac cagcggtgcg tgcctccaca cccgcgacct
     4981 tgcagcgtcg aggagttcgc ccggctggtc gccgatctcg atttgctcga cccgggcatc
     5041 accacgaccc ggtgctggcc cgagccggag gagacccgcc acccccgcgc gccctacacc
     5101 ctggccgcag tcggacgtat tcctgaacgc cgccccgacg ccagtcggag gggcgcacca
     5161 tgatccacaa cgaccggtgt gacgatgagc ccgaccctcc tcgtcggtct gtcggccacg
     5221 ctgctgctgg tcatcgcggt gctcgccttg cgagtccgcg cccgtcgaca gcggcagcgc
     5281 tggaacaacc gtccggactc ggtagcggcc atcaccgctc gcgtcgcggc ggagcgaaaa
     5341 caaccgcgcc aagtctggcc cacctacgac caggacctgc ggaacaccaa cccggaaagc
     5401 gagcagccga cactgccgct gccccgtgtc cagagcctac ggccacggct ctacttacga
     5461 ccgacgtcgc atcccagggc atcgagcgac accctcgacc cgctgccatg cccagagcag
     5521 tcggaacatc ggaacaccgc cacagccccg tttcccgctg ccaggctcgc gagcttcgct
     5581 acgtcggtcg agcacacaag ccaattacct gacaaccgcc cgtccggtga gccgatccgc
     5641 gcgaaacatg gagtcatatc ccacttggag cacccgattc gcatggccga taacagatcc
     5701 gacgaaccga ctcgcgacct cgcacacccc gtttccgctg tcccggtacg tggagggttg
     5761 agccagcgcc acaccacaaa tcccgcggag tcgggacagt cgctatcgcc gctggacatc
     5821 caaacagcac tgcacgacga gaccctggac agggcgtttc agcaaaggct gcaccttgct
     5881 cacgaccggg acatccttcc tctagtccct ctcggatacc gactgcgagt gctacgggaa
     5941 gcccgaggac tgtcccagcg ggaattggtc cggcgcgcgc acataggacg gcatcgcgtc
     6001 gttcaggccg aggagccgtt cacaaaaccg agaattccga cactggtaca tctggcgggt
     6061 ccgctccagg tcgatccgat ccagttggtg ttgctcgctg tagacgattt cgttgcgcgg
     6121 ggtccccagt ggtccgcgct caggctagat ttgtcgaacc catattcgta ttcatttccc
     6181 gtcaatgaga acgtcgcggc catattattt tcctctgccg aatccgccga cggtcaggcc
     6241 atgccgcttg gtgttcgtct ccggcaggcg cgcgtgcgag gcggtatcac gcggaattct
     6301 ctggcgaatt cctcgcgata tagcgaagaa ctgatcaaac atgtcgagat tggcctacga
     6361 gagatacaca ccgtgccgct actggtcggc ttcgccgtcg gcctgaaggt tccaatggac
     6421 cagttcgccg cgctgatcgt caacgacatc caggcccggg tcatcggcac ctcgataacc
     6481 agcagcgaca atcccagcga gccctgccgg accggcgtgc cgggacacga caagcccgcc
     6541 ctgcgcgcgg tgaccaaact cgacgacacc ctcgaatagc cgggccctgc cgccgatgcc
     6601 gttcattcac cccagccgcg ggtcaccgac ctgctcggcc caagaaaatc cattgtggac
     6661 aaaagtcgct gttttttcag acgggaaaga caacctccgt gaacaagaag atcatgtcgt
     6721 tcgcagcagg cgtcgcggta agcatcgccg ccgcgctgac cgccccggtg accgcagcgg
     6781 tcgccgacac cccgcctccg gtcgagccga tgcttgtcgg cgggcacccg gccgcgagcg
     6841 ctcccgccgg tatcacctcg ctgtagtacg acgcgcccgc gcacggcgcc cagtacgtca
     6901 atcaccacac ctgcggcgcg gcggcggcgt tccgcggctg ggtggtcacc gccgcgcacc
     6961 gcgtcaccga cccgccagca ggcgggggca gcgggtccat gccccggcgc ttcgcctccg
     7021 acgcggcgcc gatcccgacc gcggacaggc attccacgtc cgggtcggca gtctcgatcg
     7081 gctctccggc ggggaaaccg cgacggtgac caagatcgtg gtccacccgg gctggaactg
     7141 ggcccaggcg cgccaaagcg caacgtctcg gatatcgcca tgctcaaact cgaccacctg
     7201 ctccagcagc cgaccctgcc gctggcgcgc gagaccgccc ggcggggcgg cacgatcagc
     7261 ctctacggct ggggcgggac cgagcccgat agcaccagcg ccgacctgcc gctgcacctg
     7321 caacaactcg acacccacgc caccgcgccc tcccgctgcg cggacgcggc catgtccgtc
     7381 ggcgagctgt gtgtcgacaa ctcctcgggg accgacggca gctgccacgg agactccggc
     7441 ggacccgccc tggccaccgt caacggcgtg cctcagctcg tcggtggcgc cagccgcgcc
     7501 gcgaccgagt tctgcggcgc cgcgccgacg tgtacaccag ctcgccggac ttccgggact
     7561 gggtctacca cgtcgcccgc accggcaacg ccacctagcc accaagcccg ggctgccgtg
     7621 cccgtgccga gcacagcgcg gcacccgggc ttcgtcggaa aagacccgct tagggatgac
     7681 gccgatgaac cactcgacca gcgcgaccgc gaacgacacc ccgcggtggc cgacaccgga
     7741 ctttcttcgg ctcgaacaac ccagcgcggc ccggatcgcc gactgggtgg ccggaaccag
     7801 ccacaacacc gccgtcaacc ggcaattcgg cgaacaagtc gctgtcctgc gtctcgttgc
     7861 cgagatcgcc cgccgcaccc tcaactactg gctggccgac ctcgacccga tccaggtcga
     7921 ccaccacgac ggcctgttcc tgcactgcgt cgccgcgcgc atactcggcg ccgacgtccg
     7981 ggaacaaaca tgagcagccg cgccggcagc gccagagccg cgccgcggcc tcgcggaccg
     8041 gcaccaccgg gcatagccag ccagtacgaa gctggtgcgt ccctgcagcg gctcgctcgc
     8101 cgctaccgga tgtccgccaa gaccgtccgc gcacacctgg tcgccgctgg cgtccagatc
     8161 cggccgcccg gtcgcttaag gcgaactgcc catccaaccg ccccaaccgc ggcttcgacc
     8221 accgccgtga ccgcggagca acgaccagcc ctggccacgg tccaccctct gcggcctcgc
     8281 cccagcagcc agcacgagga cccggaaccc gagccgccgt ggccatcgtt cgacctcgac
     8341 gacctcgtcc ccccccgccg tccccgagtc gcccgcgaca gcgaaggccg gcgagccgtg
     8401 tatcggcttc accaccccgc agaccgtgca caagatcagc gagaccccgg tagcgactcg
     8461 attcggtgag cacacggccg ccttgacccg gtgcgcgctg atcggcctcg tcgacgcccc
     8521 gatccccacc gacgcccacg cctgcgccga atgccaccag tacaccccca ccgccacgag
     8581 cgaccgacgc tgacggactc ggtggccgca cccgtgggtg acacctcgac accgacagcc
     8641 gccatacggc ccgggagtat caagcccgcg atgactccgt ggtgcccagt cgacaacgca
     8701 cccaggccgc atggctcccg actgcctccc gctaaactta ctcgcgggcc gctagctcag
     8761 ttggtagagc aaaggacttt taatccttgg gtccagggtt cgagcccctg gcggcccaca
     8821 agtttccgca gctcaggacg tctttcctgt taagctcggt gacgcggcct cggacggtga
     8881 ggctgcgtga ggtacctggg cgaggtcgct caaggcttga ttccgacagc ggcgagtccg
     8941 aggcgccggg taggcgtcgg tgtggtcatg gtggggccgt cgggccacca gtcgtcgaag
     9001 gtcacgaggc cgggcggcac gagttccagt ccgtcgagca gggcctcgat ctcggtgcgg
     9061 gtgcggtacc ggccgggctg ggggcagcgg gcctgccagg tggcttccag cgcgcgggcg
     9121 gcgtcgtgtt cggggccggc accggggtcc caccagtggc tcacggcgat ggcggaaccg
     9181 ggtgcgagcg cgtcgcggta ggtgtccatg agcttgtcgg gatgggcgtc gtcgtcgacg
     9241 tggtgcagtg tgtcggtgag cagcagcccg atcgggcggg tgaagtccag gaacgcgtcg
     9301 gccgcgggga cgagttcctc ggggtaggtg tagtcggcct ggatgacgag gctgcgctcg
     9361 ttctcttcca gcaaggcgcg gccgtgggcg accacaatgc aatcggcgtc ggcgtagacg
     9421 atccgggctt cgtcgttgtg gcgctgggcg atctcgtggg tgttgtcgaa cggggtgggc
     9481 agtccgaggc cgcagtcgag gaactggtcg accccgatgc tggcgaggta ccgcacggcg
     9541 cggatgtgcc acgcgcgttc ggcgcggacc aggtcgctga agccaggggc ggcgtgttcg
     9601 agcgcggcca ccaggtcccg gtcgatggag tagttgtcct tgccgcctag cgcggcatca
     9661 cgcacccggg ctaacccggc gcgggtggtg tccagcgcgg gacacaccgg gtgggtgcta
     9721 ctgatgtgcg ccatgactgg ccttccccgc gggtgggctc gttcaccccg actcgaacga
     9781 acccgcttga cactgtaacg gcgtgcgcgg gctccgcacc cggtccgccg ctgtactgga
     9841 ccagccgtgg cgcgacggcc cggctggcct gttcggactg ctgtgtgacc ggtccccgcg
     9901 acgcctatga cggcggtccg atgggcctcg tcggccggtt ccccagcggc gagccgcggg
     9961 gtcgttggcg ccagggcgct gcttttccgg ccgcatgccg ctagccggcc accggcgatg
    10021 ccggggcgtc ggtgtcagcg ggggtgaggg ggtgggcgtc caggatcgcg gtgcgggcgg
    10081 cgtgggcgag gatggcttgc gtgcgcgcgg tgaagccgag gcggttccag tggaagatga
    10141 tcgcgtagct gatgatctcg cggactcccc ggcgcaggtg gccctcgcgt gccgcggtgc
    10201 cgagcgcgcg gccagcgtcg cggaatgctc cggcccaggg ggcgatgggc gcgagtggcc
    10261 cgccggggcg gagcagtggc ccctcggtga ggtcggccag cagaggctgt cggatggctg
    10321 cggccatggc ggccacgttg ccggaggtga cgtcggcggg cagcgggcgt tgccgggcga
    10381 cgtggtgcca gatgtcgcct tgctcgtacc actcggtgtg ggcggcgcgc atgagtgtgc
    10441 tgcacagcag cagggacagc tcacggcggc cgaggccgat gtcgtggtgg ggcagggtga
    10501 ggatggcgtg gctgtcggcg caaaacaggg cgtgggcagt gtcgattccg ggccggtcgc
    10561 cgaacgcggc ggtttcgggt tcgtagatgc cggtccacca cgagtgcagg tgaccgcgcg
    10621 cggtgaggtc gtcgaaggca ccggacagcg tctccgtcag gatttgccag tggccgggac
    10681 cgcagtggag ccgcagccgc cagcagggat gtttgcggac gaaccaccat ccgctcgtcg
    10741 tgccgtcgtc gacagcgagg gcgagtagcg gggcgaggtg ctgtgccgcg gtgtgttcgg
    10801 cgcgatccca gtcggggaag cgaaggtaga cctgccacca gccgggatcg gtgtgctggt
    10861 cgagcgcgcg ctggcccgcg tcgcggtaga cctcgaccgc gtcggtcagc gccgaaggat
    10921 ccatctcggc cgccgtggcg gcctgggcga gaggaatgcc agcgaggacg gtggcgatgg
    10981 cgtgctcgag ggtgcggcga gcggtcaggt gatcagcagg catgcatccc atcccgagat
    11041 cggtggtgtg tggtgggtcg cggtgtgtgc ggcgagggcg agtcctgcgg tgccggtgag
    11101 caatccactg ccctgctcgg gttcatcgga gtcggcgtgg ctgagcgatg cggccaggcg
    11161 tggcaggtgt gcggcgatgt tcggggtgag tgcgtcctgg gcggcgcgcc aggcggtctg
    11221 gtagagcccg gcccagccgt ggcagaggct ggtgtcggtg acgtgggcga gttggccggg
    11281 atcggctagg caggcggcga gggcgtcttc ggcgaggtgt tgccgggcgg tgtcgccggt
    11341 ggcgatggcg gcgatctgct gggcgcgggc gataccggga gtgccgtagc accagctcgg
    11401 tcgcagtggg ccgcgctgga gtgcccggcc ggtgcggatt tcgtcgaggg tcagccattc
    11461 cggccaccac gggccggaat cgtcgtcatg gcgccaggtg tccaggtgcc cgcagatccg
    11521 ggcgattgcg tcggcgtggc cttcgacggt gacgccctgt cgcagcgcgg tgccaagaaa
    11581 agccagcacg ccgcaaacac cgtgggcgag gccgaggttc gcgtgaccgc ccggtgtcgc
    11641 gatcgtggtg tccgggtcgt gggcgaccca ccagcccggc agttgatcgg gccggggttc
    11701 ggtcaggcgc acgaaatagt ccagaacctg ttcgagtaca tcagcgtcgg ggttgtgctg
    11761 gagcaggagc cgtccgatcc cggtcaggcc ggtgaacacg tcgtactcgc cgaagctcgt
    11821 ggcctcgccg cggctggcgc gggccgcgga ggtctcgacg cggtgccggg ccagaacgag
    11881 gacgcggtgt tccagcatgg tggcggcgcg ctggtagcgg tcccgcccgt ctgcctgggc
    11941 cgcactcagg aggaaggaga tcgccgacgc gccgaggtag aggttggtgt cggcggcggt
    12001 gctgacgccc cgggaggtcg ccgccgtgac ccacgcgtga gcggtggccc aggacccggt
    12061 gctggcgaga gcgcgttcga cgtgcagcaa ggcgatcccg gcagcgccct cggatagcga
    12121 ttgctcccgg ccgctgtggt catccgggtc aatgaccggg gccgccagct gcgcggccaa
    12181 ccgctcggag agcgtgcctg gttgttgcgt ggtggtcatg cccggtcctg gtgcaggagg
    12241 gcgaggcggc gttgggcgat ggcgcgggtg agacggccga tgatcttttc cgtgccaggg
    12301 tccgcgctca ccgcgcgcag gtggtggttg cgcagcagcg tccgcagcac cagccgttcc
    12361 tcgacagtct cgtcgtgtgc cgcgtgctcg cggtaggcgg cgagggcgtg gtggcgctgc
    12421 tgccacgcct cggtgagagc ctgttcgctg tgcagaggcc gcagctggcc gtggtggtct
    12481 acgagggcga gtgcggcgtc ggcgagcgcg cggtcgagct tgcccggttc gtggggcagc
    12541 aggtcgacca ggtcgcgcaa tccgaggtgc ggggcggtcg ccagtgatgc ggcgatttcg
    12601 gtcatggacg ccgccgcgag ggcttggcca ggtgtccagg cacgtttcgc gcaccgcagc
    12661 tgttccacgg cggccactga gtccgcggtc aacaccttgt cgatggcctc ccgcgtttcc
    12721 ggcttgtggc cgaggacggc cggggacggt gtgggggagg cgtaggtgag ctcggcgagc
    12781 agacctgcct catgcagcgt cccggcccag cccgcgagcc gggcggtcac ggcctcgtcg
    12841 gtgtcggggc gggtgcgtag gcacagcacg aggtgctggt cgctgtcggc tcgcgtcggg
    12901 tcgtggtgcc gccagaacca ccatggcaga gcatcgtgct cggtgctggc gtcggtgatc
    12961 agggcgggca ggtagtcggt gaggatctcg tcgaaccgcg cgggatgggc gtgcaggtgt
    13021 gcgcggatga ttcccgctcg gcccggcata gccgtgtccg agcggcgcac cgtgacgcgt
    13081 ggccgggccg tccgtgtcct gtcgtgcccc ggtgtggtcg ccggtggggc ggcgcgcagt
    13141 gggaccacca gttcgcaggg tcgcccggcc cagccgctgt tttcgtgggg tccggcctcg
    13201 cgcagttcga ggttcccggt gcggttgcgt tccaggcggc tgcgcagcag cgcgcgatcg
    13261 gcggggtcgt ccaggtcgag cgagagccgg agttcgcctt cgaccaggac gacggccgag
    13321 ggcgcgtgcc atcgggtctg ccaggtgtgc agcgccttgt cccaggaact ggtgcccgcc
    13381 gcgggcggga cgtcggtggg ggtgaggtgc cagcgggcgg gcgagaggac ggtgcggccg
    13441 tggcggatgc ggggcacgaa gggcaggccg tcggcgacgc cgtagccgaa cgggccgtac
    13501 accgcacggc gcgcggaggc gacctcggcc aggaaccgcg ccagcggcgg agtctgcatg
    13561 gtgttctgca acgcgtgcgg gatgtgcggc tggacccgct ggccggtgga gatccgcacg
    13621 agcgcgatct catctgcgtc agcggtcacc gccagatcgt ccagcgcgat cacggtcggg
    13681 tccgtggcgt ggtgttcgcc gagcgggatc aagtacggca ggaaccgggg tacgcgcacg
    13741 atgttctcgt tgcgttcgcg ccggggcggg aacgacagct gcgcgcagac gacgtcggcg
    13801 cggtccgggg cgtagctggc ggccagccgt tgccggtcct gttcggacag cagacgggtg
    13861 aagcgtccgg ccatactcgt ggcgtgcatc ggcacgccgg tgacccacaa ctggaaacgc
    13921 ccgcgctcca acgcttccgg tgaggcggcg tgcagctgga acgccaactc cgcccgggcg
    13981 ggcgcgacga gtttcgcgtg gtcgccgaca cggagatcct ccaggacgga ctcggtcacg
    14041 acgatctcgg cccggttgtc agtgctggcg cgctggatca gccgcagcag ggtgacgtcg
    14101 cgttcggtga ccaggtgcgc ggcgcgcggg cgggccgcgc cgagaaaccc ggcggggaaa
    14161 cccagcccgg agtcggcgac cacctcgcgc acgccgacca ccgcgcccgc gccatagcgg
    14221 tccaggaacc gggcatgcca gtccttccat gccggatcgc cgaacgggaa cggcgtgagc
    14281 cgcagcagcg tcgtcgcggc actctccgcc tcgcgcagca ccgcctcggg aaccgtcagc
    14341 tcgccggcca ccaccacgtc caccgcttgg acccgccccg ggctcgggtg gaccgcgcgc
    14401 atccgttcct cggtctgctc caacgcgacc gcgtgttcgg ccatcggcgc ccaggcacgc
    14461 gccaaggcca gctcgtcgcg gatcgcggcg agttcggcgg tgatcttcac gaggtcgggc
    14521 aggtcgtcga tgcccgcggc gtcgagttcg gcgagcaggt gcgccatcgg ttccgtcgtc
    14581 gtcagcggcg gtcgcagggt ggcgatcaag gcgccgctct cgaccagttg cgcgagcagc
    14641 cgagcgattg cctcggggct cgtgcggggg aactcggcgc cgattcgctc ggccagctcc
    14701 gccgtccgca ccggtgacgc cgcaccgtcg agggccgccg cgaccgcgcg ggtgtggcgg
    14761 atggaggtgt cgagtgccgc gccgcgctgg ggctgggtct cgtccgggcg tgcgggagtc
    14821 acgacccggg tgccacgccg gaacgcggcg ttgttggtga ccactgtcaa gcgcggcagc
    14881 aagtcgtggc ggcgctgcag gcccgtgatg atctcgccga accagcgggc gtccgcccgc
    14941 gccgacaccc ggcattccgg gtcgaggcga gcggacgccg aggtgccgat ggaggcggcg
    15001 gcgaccccgg cgaacaagcc gaacggggtc gcgcgccgcc tccaccgcag cagataggac
    15061 gaggtggccg ccagcacacg ccgaacctgg cgcgggtcgc cgtcgtcacc ggcagcgagc
    15121 tggtcgatct gctcggccag cgcggggctc gcgatccgca gcgcgacgcg gatctcgacg
    15181 cgttgccaca gtcgcgccag ccaggcccgg ccggtcccgg cggcgtcctc ggttccggcg
    15241 gacaggaact cgggcacgtc cagcccgccc gggttcgtgc tgatccgggc cagcaccaga
    15301 tcaacgtgtc ggaacaaggt gtgtttcgcg gccatgcgcc tcgccctgcc ttctactcgg
    15361 agtcggtcac aggggtgtgg cgacgtggct ggtgcacgcg gatccgcagg tcgtgccgcc
    15421 gcagttgtcg ctggtgtcgc acgacatctt cgccagcggc aggctgtcgg cgatcaccgt
    15481 cagatccagc gagaactcgt cggcctcctc ggccgggggc gtgagggcca gggtcataat
    15541 cgatcactcc ttctcggtta cttcttggtg ttcctgacct gtcggggacg gccaggacgt
    15601 cgtgatgcgc tggtgccgct tgtcgacaac gacgccggtc ggcagccgct cgtccggggt
    15661 gccgggtggc cacacgccga aggtgggccc ggggccgtgg cgctggtcgc ggtcccacgt
    15721 gcggatctgc tcgcagaacg cggtgacgag gtcgtccgcg tgcgggccga aggcgtgcgc
    15781 gccgaattcg gcgataccgg gttcgacgcc gcgcgtggtc aggtacgcga ccgagtcacc
    15841 gtcgatggcc gcggagtcga accacaccgt gccctcgtcg accagcactg accgcagcga
    15901 tgcctcggcg cgcagcttgc cgaagccggg aaagacggtg gccagccaca gttgcagcgt
    15961 ctcgaacgac tcggctccgc cgatccgcac gcccgtccac gcctcggccc gcggggtgtc
    16021 gagaacgccg tccaggtcgg ggacctgctc gccgggccac ccgtcgtcga accgcattac
    16081 cgcgtcggta ccgcgcagcg gcaccagttg ctcctggtgc gctccggtgc cctgcatggc
    16141 gacgaatccg cagatctccg ctgaccggct caccaggtgg tcgccctcgc ggaccagttc
    16201 cagggaacgg gtcagccccc gcacccgcag cggcaccacc agccgaccgt cgggggcgag
    16261 ctggtccagc cacgcctgcg ggatgtccca ggaaccgacc gtgacgatga tgcggtcgta
    16321 cggagcgaac tcggcgatcc cggtctcggc gtcggcgagg atgacgttga cccgttcgta
    16381 gccggcggcg tccagcagcc gccgtgcgcg ttcggtgacg tcggagtcga tgtcgacggt
    16441 ggtgacctgc ccgtcgggtc cggcaagcca tgccatcatg gccgcgttca ccccgccaga
    16501 gccgatctcc aatacccgca tcccggggcg gatgtcggcc tgctccagca ttccggcctg
    16561 cagctgcggc gaggacaccg tgctgatcgg cacgccgcgc tcgtcccgct tcacatgcac
    16621 cgcgtcgcgg gggctgtatg cctccgccgg tgtcgcctcg ggggcgaaca ggtgccgggg
    16681 caccccgtcg aacacggcgg cgacccggtc gctgcggatc gcccgcatct cccacagctc
    16741 ggcgatcatc gcctgccgca actcggcggg gtccccggcc gcgcgggcgg catcggtgtc
    16801 ggtgtgtcca ggtgtgctca tccgttcctc tctcgaaaac ccttgtctcg catcatgttc
    16861 tcgctgacgc cggggaatgc tcggctcggt cttgtgccga cgatcgccac tcgggaagtt
    16921 tcgtaccgta tcgaggcgat caccctccgg tgagctgccg ggcgggcgcc acgggccgta
    16981 gccggtgccg tccggctcga tcgggcccgg atggtgcgtc gtcgccgatg agctgctggt
    17041 gagcggtctc ccacacggtg cactcgttgt gtcgccaccg gggcgagcag cgggcgcacc
    17101 gaccccggga gtcgggagcg tgctggtcga gcaatcgccg ccacgcggcg gtcaggcggg
    17161 cgacctccgt ttccgccagg gcggctttgg agggcgtgtc gccgtccgcg accaagacgt
    17221 cgaggtagtt caggtgctcg acgacagtct gctgaagcgt ggcggtgagt acctcgtcca
    17281 tcaggggtgg ctccttctac tcgtccggat gtcgtctctg ccgctggggc cagaggcgct
    17341 catgcagctc gctcggcacg aactcggcga ggcgtaaccc ggcggccatc aggcgcctgg
    17401 ccgcgtcgtc gaaccagttg cacggccacg ggtcggtcga gcagcacggg cagacgtagg
    17461 gctgatcggg cgacgggaga tgacgcgcgg cctggtcgac agcctcggct gcccgaccga
    17521 tcggactgtc gcgagcgacc acgacggcca cacacgctcg ccacctttcc gccacggctc
    17581 acgcgctccg cgccgacctg cccgccgccg accagctccg ctggccgaca ccgccacttg
    17641 cgcggctccg accgtggcca tgccgggtgc tcactactgc catggttcga ccctgacccg
    17701 ggtccacggc agcaccaagc cggaaacagg ggatgtcaag gggaggattc ggggagggtt
    17761 gccgtcctcc cctgtcgacc gatggtgtcg acccgaccac gagctgtgtc aggatgaggc
    17821 aggtcagcac gtgggagggc ggcccgcacc gatggacaac gatcagctac ggcaggctcg
    17881 ggaacgcacc gagtcctcga cacagccggg agagtgcctg tcccgtgacg agttggctga
    17941 cctggtcaat cagcacatct gggtgcacca caagaaacgt gtcgtggcag acgcgaacta
    18001 catcggcaag ctcgaacgcg gcgtgatccg ctggcccagc gcgctctacc gggaggcgct
    18061 ccgaggggtg ctgggcgctg ctaccgatgg cgcgctgggc ttcaccaacc ggcggcggac
    18121 ggtggtaaag ctggcggacg tggatcgcaa gaagttcctg cgtggcgtcg gcctcggggt
    18181 cggcgcgctg acactggctc ccgtcgctgc gcgcttccag ggcagcgagc ctacgcccgt
    18241 gccctcgcgg gtgggcagcg ccgagatcgg tcagatcgcc accgcggcga aggtgttcgc
    18301 cggatgggac cacacctacg gcggcggcct cgcgcgcgaa gccgtccagg cccagctgca
    18361 ctggtcagcc ggtttgctcg acgccagttg ccacgaggcg ctgcgcggcc cgttgcgcag
    18421 cgcgatcggc tacctggccc acacctgcgg gtttatggcc ttcgacgcct acaagcacgc
    18481 agacgccacc aacgccttcg agttcggcct cgcctgcgcc gaagaggccg gcgactggca
    18541 cctgcgcgcg aagatcctct cctcgatggc acggcaggcg atctggcgcg gctaccccga
    18601 cgacggcctg acctcgatcg agcacgccct ggtgcgcgcc gaccggctga ccgccaccga
    18661 gcgggcgatg ttgtacaccg cccatgcccg cgcgctggcc aagatgcgcc gcacccggga
    18721 ggctctggcg gccgtcggcc gcgccgacga ggagttcgcc cacgccaccc cggccaacga
    18781 tccgccgtgg atggcctact acgaccatgc ccagcatgtc ggcgacaccg gtcatgccct
    18841 gttcgacctc gccgtcctcg ggtaccggcc agtcgacgcc gcggcgcggc tcgcggatgc
    18901 cgtcaccggg cacaccgacg cctacccccg ctcccgcgcg atctcccaaa ccaaactagc
    18961 caccctcacg atggccaccg gggaccccgc cgaagccgcc gtcatcggcc aggccgcgct
    19021 cgacgccgcg ggcaccgtcc gctcccgccg ggccgccgac gatctgcgcg agctgtcccg
    19081 ctacgcccac cgccacagcc gcacacctga ggtcgccgcg ttgcgccagc gcatccacac
    19141 ggtgctcgcc gcgtcgtgac cacgaccgga accgaagaag ccgaagagct actgcgcgcc
    19201 gcctgtgacc aggcaggcgt cgacgcacgg ggcgctgagc ccatccggct cggggagaac
    19261 gcgatcttcc ggctccccgg tggcatcgtc gcccgcatcg cccgacccgg tcagctccat
    19321 gccgccaccc gggaggtccg cgtcgcccgg tggctcgccg accacgacgt ccccgccgtc
    19381 cgcgccctcg acgacctccg ccaacccatc gaggcgcacg ggcgtgcggt gaccttctgg
    19441 cacgagctgc ccgcccacca ccacggcacc cccgctcagg tcgcgacggc actgcgccgc
    19501 ctgcacgacc tgcccgtcgg caccgggcag cacccgttct ccgcgctgga gccgttcgtc
    19561 cggcttgacg aacgcatcac cgccgctacc agcctcaccg acgacgaccg cgcctggctg
    19621 taccagcacc tcgccaccct gcgggagcgc tacgaccacc tccccgccgg tctgccgcgc
    19681 accgtgctgc acggcgacgc ctgggtcggc aacgtcgtcg ccaccaacga caatcaggtc
    19741 gtgctgctcg acctcgaacg cgcctcgatc ggcccacccg aatgggacct cgtctccacc
    19801 gccatcaaac acaccagctt cgcctggatc agcgagcacg agtatcgcga ctttcgccac
    19861 cgctacggcc acgacgtcac cacctgggac gggttcgcgt tgttgcgcga tatccgcgaa
    19921 ctccgcatga cctgctacat ggcccagcac gccgccgaaa acccccgcgg ccaccgcgag
    19981 gccgaactcc gggtttcctg cctacgcggc cggaacgggc tccgcccctg ggcctggtcg
    20041 cccgcgtcct aacgacggat tcacatcgac ctcggcgtcg gcaacgctac cggccggatg
    20101 aggctggtgg gttctgatca tggcctgacc gccgtagtct gctctcggta gcgggctggt
    20161 tacccgactt gagggggtcg tgtggatctg gcggatctgg caggtgaggc cctcacgctg
    20221 ctggcaggtt tcgcgggagc ggtcggtaag ggtgctctgg acaaggccca gaacgacgcg
    20281 atacaggcgc tctacaccgc ggtgcggcag cgtctgggcg gccgtcgcgg tgacgccgcg
    20341 gcactgaaga acctggaaca agcgcccgcc gaccccgggc gccgggaggt cgtcaccggc
    20401 atcctgcacg acgcgctcga ggctgacccc ggattcgccg ccgagctgcg ggaggccgtg
    20461 cgacaggccc gggtgacgat caatcacgac ggtgatgtcc gtgccgggcc ggtcgccggt
    20521 gaccaagccg tcggcaccat cggctccggc tcgtcgtcga acaccctgat tcagaacaac
    20581 tccgggtcca tcgatcagtc gcaccacgcc accaccgaca accgcagatc caagaccacc
    20641 aaccgattcg gcatcggcac gacaccgctg gtgctgatcg ccgcgctcat gatcgccgtc
    20701 gtgaccggag tgaccacgag cgtcatcgtc agcgtcaaca accccgcgtg gttcgaccgc
    20761 ctcttcccgc cacaggacga cgtccccgac ctgcccgcga acgtagctga tggcaagcca
    20821 taccagtact tgccgaccca gccgtacgag gccgtccgcc acgtttatga attggtcgac
    20881 aagaacgatc ctgcggcgtg cgagcggttc gaggagaacg tgcgcccggt gttcgccagg
    20941 cacttcggcg cccctgactg cgccgccgcg gtcacgatgc tgcacgcgcg ggtgaccgac
    21001 gactgggcgt tcgcgttctc ggttcgccag cgcgactcga ccgtccactt tccaccgacg
    21061 atgaagatca gctcgtgctc gttcccgatc aagggcggcc cgtcgctcgg cttgttcacc
    21121 ctgacccgtc tcgacaaggg ccagtggctg atcaccaacc acgagaccga agccagcccg
    21181 tgtcctccag tccgctaggc acgacgctga cgcgagtccc gtgacgcggt ctgcgaggaa
    21241 ccagcggttt gaaggtggcg tcgtcgcgct ccacgccagg tgtgctcaga acggccaagc
    21301 cagcgctggg tgtctcgtgt ggaacgaatc aaccttccac ctcaaaacca acggtcaggg
    21361 cgacgtcgcc aaatgtcccg ggaaagttgg tcggctgtga cgggggtttt actttttcgc
    21421 ttgttggagg aggttgaccc attttcggac tgtcgtcttg tcgcccttct tgagtaggcg
    21481 catgtgcgag aggcggtttc ggatagggat gacctgttgt gtgaatttgt cccacgtgac
    21541 cttcttccag aagagcccgt cgaatctttt cgagcgaacg agttcgagta gctcgccgag
    21601 ggacaaccat tcgatggggt ctcgtagttc ggcgatactc gctgcgtccg ggtgggcgtc
    21661 gtcgcgtgct ctttcgagca ccgttttcgc gagtgtctcg tggaggaggc ttttgcgcca
    21721 gttcttcacg ttgggttcgt tgaccgcggc gtctcgtagt gttttgcgga tggtgcgctc
    21781 gatgttccac agtccttccg atacctcagc gaggtcggtt tggggcgaca cgttgctggc
    21841 catgacgtct ccgatggcct ctttgaactt ccacaagagc cgaggtgcgg tgagggagat
    21901 ttcgtcgttg acgatgtggg cgagacccgc gctgcgcagg gtttcctggg tgacggcgtc
    21961 gacctcgctg atgaatcggg tgttgtggcg tgcttcgaaa agggcgtagt ccagctccgt
    22021 gaggatgctg acgccgagtt ccgccagtgc ggtgcgcagg atggtggcga catcggtgtc
    22081 gctgccgaag ccgattgcgg gcagcgcgaa ccccgggtgg tcgcgagttg tagcggggca
    22141 ctcgtcgctg cccagggctg gcaggcagtg gagcttggcg tcgacgagga ggttgctgcc
    22201 gacgacgggt gcgaaggcgg tccgggcgac gcgcgagacg aggcagacct cgatgtcgcg
    22261 ctcgagcagt tggaggactt ggacgcggag cgtgccgatg gtggtgcctg cggctgtgcc
    22321 gtcgcgtgcg aaggcttcca ctccggtcag cacgacctgt ttcgcgccgg ggccgatgag
    22381 gcccggcttc ttggcgaagt ccgcggcgtc gagcacggtg gtgtccagct gggccaggag
    22441 cggttcccgg agtggttcga acgccactcc gcactggatg aacaccaact tgaagcgggc
    22501 gagccgcttg cggacttcca gcgcgcggcg tcgggccgcg ctgagtgtca ggtcagtcaa
    22561 ggctgtctcg gtcatagcag gtgcagcacc ggggtgagtt cgtaggcgtt gtcgaccttg
    22621 tggaccagcc cgaggctgag caggtggccg agcgcgagag gggcgtcctc ggcgaacgcg
    22681 gtgaacgact ccggctcgtc catcaggacc tcgagcaggt aggactcgtc cgggtaatac
    22741 ctctcgacgt ggtcgagcat ctcgcgcatg ttcccggcga catcgcgccg ccactccgtg
    22801 atcgtccgca ggaccagcgg cttcttgatc tcccggtgga aggtgtccac aggaagctgg
    22861 tcgaccactt tcgacgccag gtgccggtag aggaatgcgt gccctccggt tgcctcgaac
    22921 aaggcgtcga gtgcgccggt gtcgatgctg acgcccatct tctggcctac cgaccgggcg
    22981 agctcgtcgg cttcgtgccg ctcgaaaggg gcgaggaagt tcgccttcgc ccaggagaac
    23041 agcgggttcg gcctcccgta cagccgcccg ctctcgatga tcgcgctgat cagcccggac
    23101 aacaggaacg tgaagttgcc gttctcctgg acaaggctgc gcagcgcgcc gaggagctgc
    23161 gagaccgagg tcaggtcccc ctcgtggatg tcgatccggt cggacggggt gaggtactcg
    23221 atctcgtcga gcatcaacac gatggtgatg ccgtcctcgg cgagccgacg gagcacggtc
    23281 tggaaggccc gtttgaaatc cgagacggtg ggcgtcgccg acaggctggt cagcgcccgt
    23341 gtcgtgagcc tgcgctgccg gagctcggtc accaggtcgg tgacgaggtc cttgagaaga
    23401 tcgggcaccg gatcctcggg cggcgatggc aggctctcca gatctcgcaa gatgaagatc
    23461 gtctccggac cggacagcgt ctgttccagc tcggacagca cgctggtctt cccggccttg
    23521 cgcaacccga acagtccggc gacgcgctga tggcgaatgt cgtcacggag ggtctggagc
    23581 agttgacgac gtccgaagaa ccggtcaccc cgcaccggtg tggtctcgta gaacagatcg
    23641 cgagtgaaca cgtagctgct gagaagcttg acgaacgcga tcgggtcacc gtcgtcggga
    23701 agatcgagcg ggatggccag aagatccttc gaccagtcgt cgagtcgttc acgcaggcgc
    23761 gggtcggggg accagaagaa catcatgtcc ggagtgacct cgcggtgctg ccggaggctg
    23821 gtgagcttcc gtttcgccgc ctggaaggtc ctcatctgca gatcgcggtg ggggctatag
    23881 aagaagaaca cctccctggt cagcccgaag gccgactcga tggccccgct gaatcgcacc
    23941 aacgcgaacc cgcagtcatc ggcgccggga acgcctccca ccacggagta gaagaactgt
    24001 gacccgagct tggccaggat cgcctggtgg tcgtcgacga cggggaacga ctgcttgagc
    24061 agggcgagac ggcgcagagg ctcgggatgc gtcagtggct tgaccgctcc ggcgctccac
    24121 gtcgccggcc tcggcgtcgc ggccccggcc gcggtcgcgg cgtcgtactg gccgaacgac
    24181 tccttcagcc gcgtcgcggc gtccttctcg accaggctcg acgcgctgcg aacgtgcacg
    24241 cccagctcgg cgagccgggc catgaccttg cgggagccga tacccagctc tttggctagt
    24301 tcatgcacgc gttgccgcac gtagcgtgtt ccccctctgc tgaaccggcg gtgactcgga
    24361 tcatactggc gcgcaccgac aacttcgtcg tattaacgac ctgtgccgct gcggatccac
    24421 gtcaacgcga tttcgcgtca tccggcagta ccggggcgac gccgccgagc ctgcccaatc
    24481 cacgcggtgg cccgggccgc tgcggtgctg ttcaggctcc gagcgcgtcg ccggtgttcg
    24541 tgccagcccg cttccacgta acacggcctg ccgtcaacga ggccgcggac acccatcgtc
    24601 gacgtcatca actcgcccga gggccgccgc accaccaagc gccggaccac cttcggcgac
    24661 ggcgccaagg actccggccg ccggtgtgcc gacgcgatcc tcctgccggg cagcccgctc
    24721 ggccagcaga tccgcggcgt gacgccgcag gactcaaatg ggtgaccagc gccgccgata
    24781 tcctcatcac cgcccgcccg ccggtcaacg atgcggccgg tctccaccgt ggcaccacca
    24841 cggcgccacg tagtcccatt tcagcagcgt gaacccggac accagttgcc agctttgcat
    24901 gccgcttgtc gcaatacgag cgcgaaatgc gctcgcagga acgaaccccc gccttcactc
    24961 accgcgcctg ggtggccagt tgtcgagcag gagtcctgat cttgcaggcg tgcttctacg
    25021 ttcggaacag aaggcgcgag ccggatgggc ggcctcctct gccaaggagg ccgcccggtg
    25081 gttccggcgg cgacatcgac acaacatcaa ctcccgaagg gaaccaccga gcatgacggt
    25141 aatgcgcggc agacgactgg tgccagaacg taccgatcag gggcgtactc gacgcgctga
    25201 cgaacgcccc gaaaattgcg ttggcccgaa taacgctcgc ggcgaccggt accagagcac
    25261 cggtgagcgg tcgtggccgc aggtcatggc catgatcgtc agtacgacgc tgggcagctg
    25321 ggtgcatacc ctccg
//
