LOCUS       NZ_CP059997            41113 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4660313
            Orig. end                         :: 4701426
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..41113
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="PKS-like"
                     /region_number="19"
                     /rules="(t2pks2 or ksIII)"
                     /tool="antismash"
     cand_cluster    1..41113
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(t2pks2 or ksIII)"
                     /kind="single"
                     /product="PKS-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..41113
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="False"
                     /core_location="[20000:21113](+)"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..21113
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="1"
     gene            complement(423..845)
                     /locus_tag="HUW46_RS22255"
                     /old_locus_tag="HUW46_04409"
     CDS             complement(423..845)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229055.1"
                     /locus_tag="HUW46_RS22255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04409"
                     /product="Lsr2 family protein"
                     /protein_id="WP_215549105.1"
                     /transl_table=11
                     /translation="MAQKVLVEILDDIDGTEASQTVPFALDGVSYEIDLSDDNAAALRG
                     EFESYIAAARRTGGRKVRLATGQSAAGGGSATTSSTDRERNRQIRAWAQDNGYDIAERG
                     RLSAEIINAYDEAQQAEAEAEAKPARKRAARKKKAS"
     misc_feature    885..897
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     tRNA            1217..1290
                     /anticodon=(pos:4661555..4661557,aa:Lys,seq:ttt)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS22260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /product="tRNA-Lys"
     gene            1217..1290
                     /locus_tag="HUW46_RS22260"
     gene            complement(1539..2012)
                     /locus_tag="HUW46_RS22265"
                     /old_locus_tag="HUW46_04410"
     CDS             complement(1539..2012)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012782822.1"
                     /locus_tag="HUW46_RS22265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04410"
                     /product="hypothetical protein"
                     /protein_id="WP_215549106.1"
                     /transl_table=11
                     /translation="MSIGVSGHQNLPALARARAEKDIRALLARQVGRVIGLSSLAAGAD
                     HLFAELLVETGHRLHAVIPCRSYQETFTGADLTTYLGLRAAAHTVTELDFPSPSEKAFD
                     AAGKYVVEHCDLLVAVWDGRPAHGLGGTGDAVARARKLHRDVLITWPEGVRRT"
     gene            complement(2012..2962)
                     /locus_tag="HUW46_RS22270"
                     /old_locus_tag="HUW46_04411"
     CDS             complement(2012..2962)
                     /EC_number="3.4.22.-"
                     /GO_function="GO:0008234 - cysteine-type peptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012782823.1"
                     /locus_tag="HUW46_RS22270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04411"
                     /product="caspase family protein"
                     /protein_id="WP_215549107.1"
                     /transl_table=11
                     /translation="MRRALLVGIDHYDNMQDLSGCVNDATALEPLLARNEDYTANLSCR
                     LLTGTVNRRDLLTRVRELLADGADFALLYFAGHGMLVAGDVALVTSDGDEETLGVRFAE
                     VLEIAVNSQVKEIVVILDCCFAGGAGTVTALTNAAVLRSGMSILTASRSDQTSAESGGR
                     GLFSTHLEGALDAGAADVLGHVTVAGLYAYLSECFGPWDQRPTFKANIDRLHDLRRCAP
                     APPLATLRKLIEWFPVPEYHFPLDPSFEPDKSCSGLDPHPEHEKIFTQLQTCRANKLVE
                     PVDHQHMYFAAMESGSCKLTALGQHYWLMAKQGML"
     gene            complement(2967..3347)
                     /locus_tag="HUW46_RS22275"
                     /old_locus_tag="HUW46_04412"
     CDS             complement(2967..3347)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012782824.1"
                     /locus_tag="HUW46_RS22275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04412"
                     /product="TIR domain-containing protein"
                     /protein_id="WP_215549108.1"
                     /transl_table=11
                     /translation="MADRKTVFIAFAKEDEARRNLFTGQRVSARTPFEFTDMSVKEPYE
                     TEWKKRVRTRIVRSRGVIVLISRATPQATGQLWEITCAVEEDKPLLGIWLDDGYRTKPT
                     QMGMSRCVPWTWEAVTSFIDGL"
     misc_feature    complement(3572..3586)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.42"
                     /tool="antismash"
     gene            <3640..>3747
                     /locus_tag="HUW46_RS48390"
                     /pseudo=""
     CDS             3640..>3747
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222882.1"
                     /locus_tag="HUW46_RS48390"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="DNA-binding response regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVVILTAYAVAEGVFNALRAGAVDFLVKDTQSGDFL"
     gene            complement(3790..4056)
                     /locus_tag="HUW46_RS22280"
     CDS             complement(3790..4056)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215549109.1"
                     /transl_table=11
                     /translation="MIKLPNKLQIGHMFPAGALDNGLIMKITMASRRGRLGANVAWVKI
                     VAALAIAVAIKPLRVVESSLIRVHVAMKNDDEMSRRCTTSYLS"
     misc_feature    complement(3796..3798)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4041..4056
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.63"
                     /tool="antismash"
     misc_feature    4042..4058
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.82"
                     /tool="antismash"
     misc_feature    4115..4128
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(4285..4301)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 18.49"
                     /tool="antismash"
     gene            complement(4288..6045)
                     /locus_tag="HUW46_RS22285"
                     /old_locus_tag="HUW46_04414"
     CDS             complement(4288..6045)
                     /EC_number="3.6.4.-"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004386 - helicase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012789.4"
                     /locus_tag="HUW46_RS22285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04414"
                     /product="ATP-dependent helicase"
                     /protein_id="WP_215549110.1"
                     /transl_table=11
                     /translation="MSALSASIADLKHNPQQWQAFTSQGHCVVLAPPGSGKTKLLATRL
                     AYDLINKIPKPQGATCITLTNAAADELRRRVESLGVESRSNLFVGTVHGFALGKIIAPF
                     AEVVGREDLVNISIASENQCRSLLKDAIAEVFGNDNKKHVDSTIKINRERLAGDEDWAR
                     HSDKVREACLRYEAKLHERGLRDFTQLVTAAVEIVEKHEPIRRVLTAQYPHIYVDEYQD
                     LAPGLDRLVKALCFDQVVNAELFAVGDPDQALYEWMGARPDLLHKLAQYPGVTRVELEH
                     NYRCGEAIIQAGNLMRTSRRPIVGSRAGGQVSAVHCPGSSKEQYRHLVAYVRETIGRGV
                     PLHEIAVLATIRDQCEAVTALLRDSGIPVFFRSPEYRLTVVTGFIEAAAAWATLGRETS
                     NYRLVDLLQRWRTIFGRSWSRRDNVALTELLMNLRDHSAQPAASFVESLMERGLKRALA
                     QMEMADDAVEVERMRVALATGGLRGVSIVELAERARKVDRVEVTTMTSSKGLEFDVVLL
                     VGANEGNIPSYHSGSDSAKIAEDGRKFYVSITRAREEVRIFYYDFVVTQYDTIKPAAPS
                     RFLREIGLI"
     misc_feature    complement(4294..4296)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4498..4500)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6042..7778)
                     /locus_tag="HUW46_RS22290"
                     /old_locus_tag="HUW46_04415"
     CDS             complement(6042..7778)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024700.4"
                     /locus_tag="HUW46_RS22290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04415"
                     /product="AAA family ATPase"
                     /protein_id="WP_215549111.1"
                     /transl_table=11
                     /translation="MNNSGVNMRINRLKIKNFRNLADIDVELLPGTVVVGENRAGKSNL
                     LHALRLILDSTLSFSDRQLSREDFWDGLSDGSDGWDPLIQGQVIEASIDIVEFEDDPKL
                     PAALAEALLDDDPLRARLTYRYAPVDTGEETLKPKYRGEVYGGEGGGRAISYELRSYLH
                     LVFLHALRDVEADIRNWRRSPLRTLLLAAAAAASEDDLGEVQVAMKEANDKLNSLDVIK
                     DLSDNIGQRLVDMVGDNQAIATELAAAPDDPMRLIRAMRLFVDGDAHRNLGSASLGTLN
                     VLYLALQRLGLDTRRVDDEDIAHVVLAIDEPEAHLHPHLQRLVFGGLLDGQEATTVLVT
                     TQSPHIASVADPRSLVVLRTVGGQTVAAAAHRASLSDVEWDDVGRYLDATRAELVFARR
                     VLLVEGFAEQVLVPKLAEALGMDLDKLGISVCAIHGTHFSSYVQLCNALEIPWAILTDG
                     DVAASGARAGDARAASLLELLGRTGDAQKHGIFVGRSTFEHDLLEEPANMTAAFDSLSE
                     LCKAPSVATIESWNGQDPGYDEFMKMIKNAGGKGRYAQRLALRPVHAPQYVEAALRYLE
                     QR"
     misc_feature    complement(7293..7295)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8028..8312)
                     /locus_tag="HUW46_RS22295"
     CDS             complement(8028..8312)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215549112.1"
                     /transl_table=11
                     /translation="MTEMDRLGILFEEIGARQRATDEQPLEVAAKKEILDRVLEAQILL
                     PPGNEHIWDDFRLWIMRSWAVVLKRYGDDAAEPWRVFLVEVNEMIGVRS"
     misc_feature    complement(8208..8210)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8332..8748)
                     /locus_tag="HUW46_RS22300"
     CDS             complement(8332..8748)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215549113.1"
                     /transl_table=11
                     /translation="MNQRVDVVGPHWVLDRRHHSIERNARYGRGNRGSQRETTHEEHYV
                     VLLPDGTLKKVAVWNEEVVTIDDGSVYQFETPDHSIRSVYESDVEDMDFEKHYASHGNP
                     GDSIVTWGDQRVRGRRLLVHAKGVGLSQALKRLL"
     misc_feature    8961..8975
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.7"
                     /tool="antismash"
     misc_feature    9253..9262
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.35"
                     /tool="antismash"
     gene            complement(9518..9955)
                     /locus_tag="HUW46_RS22305"
                     /old_locus_tag="HUW46_04416"
     CDS             complement(9518..9955)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04416"
                     /product="hypothetical protein"
                     /protein_id="WP_215549114.1"
                     /transl_table=11
                     /translation="MFDLVLSEHARGTPVETLYKLVGASGLIITVCGPHDPADTTRAII
                     RAAPRLLEDHDDRTDGLVMSRVGMYRIFWGVVGFRGGSLALLVPSPAHEQQDYSDWTRH
                     FMAEVLDPVMALSGEGYSTGGGGDGFVTDAEFARAFNQVSV"
     gene            10126..10521
                     /locus_tag="HUW46_RS22310"
                     /old_locus_tag="HUW46_04417"
     CDS             10126..10521
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04417"
                     /product="hypothetical protein"
                     /protein_id="WP_215549115.1"
                     /transl_table=11
                     /translation="MTGFQHTSSFIFPTLAWQSPSEPVLKTNQPRMAIRATAMSWQNMS
                     TDGAMSELISADNFTGPPQDFKLNHVNEILGLMGSTGEQLALAWTAEQDVQRWLQTATT
                     RDPVHQRMGVRAMAERPLQPRCRAQPR"
     gene            10526..11044
                     /locus_tag="HUW46_RS22315"
                     /old_locus_tag="HUW46_04418"
     CDS             10526..11044
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04418"
                     /product="hypothetical protein"
                     /protein_id="WP_215549116.1"
                     /transl_table=11
                     /translation="MLRVLALNNEANAYLEVKLGKGKRPFTHRPGSNDRSAWQTLSPRS
                     PLARYLPEMAERTHTASCKQLAAVLVDLCHAYGYVDLDERRGMDFHRHRPQSLDSGSPR
                     SGPWKEDKDAGWRSFDLHLATPDPDYDEQLVATVAADGLEAVAAALNAAHLLLIGSVQD
                     LGYKVLGFS"
     gene            11355..12419
                     /locus_tag="HUW46_RS22320"
                     /old_locus_tag="HUW46_04419"
     CDS             11355..12419
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04419"
                     /product="hypothetical protein"
                     /protein_id="WP_215549117.1"
                     /transl_table=11
                     /translation="MLRVMLCGASDTADVRDQFAEVISGLGGEPLHYLGGGIQYLNAAD
                     SSWSRNSQITIRAADLCVFVIIERYGEITWSTELQEARTAGKPFLVLCLDRTYIKYEVL
                     RKSSIEGTDIYPEDDRRLVETLRELEFSWQLTIVSFGYGTFQQILRRQLATLFHWTLRE
                     QQDRNRRASITRLATERVRLNPVQLADAVRIATDDLEEKNIRKRAVLALTGTGVDADVV
                     LDLLSSDEQGVQRLAVVHLAKLYRDRPADPEFLAQCVHAANAAEDVGIARRLVPVLLEL
                     DLAHGLAALDLMSVAEVGIRRRIAESLEKLERAIIANELSAEAVAMLGRCLQDAAETSW
                     KARCRRLRSRLSAE"
     misc_feature    complement(11383..11393)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    11535..11537
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12423..12671)
                     /locus_tag="HUW46_RS22325"
                     /old_locus_tag="HUW46_04420"
     CDS             complement(12423..12671)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04420"
                     /product="hypothetical protein"
                     /protein_id="WP_215549118.1"
                     /transl_table=11
                     /translation="MQRIVRWNVGMTPQQWRRTDDSWNDLDGGHVSYVDVTAEHLAQVS
                     PRLHDALTHRGRLGTIVQHTYSVEGGHRIFTFVVLFD"
     misc_feature    complement(12776..12788)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    12941..12955
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 21.68"
                     /tool="antismash"
     misc_feature    13040..13053
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.76"
                     /tool="antismash"
     misc_feature    13115..13124
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.81"
                     /tool="antismash"
     gene            13188..14534
                     /locus_tag="HUW46_RS22330"
                     /old_locus_tag="HUW46_04421"
     CDS             13188..14534
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="HUW46_RS22330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04421"
                     /product="MFS transporter"
                     /protein_id="WP_215549119.1"
                     /transl_table=11
                     /translation="MRRREHGFAAALANREFRALWLVEALSVFGDQLARVALALLVFGR
                     TGSASLSALTYALTFAPEVASGFLLSGLADRFPRRAVMVTTDLVRAGCVFAMVVPGLPL
                     GVLWGLVAALSLARPPFKAAQQAVLPEVLGADLYPVGLGLRQITNQAVQVAGFGVGGVL
                     VTAIGAGPVLLIDAGTFVVSAAVLGLAVAARPAARRGKAERASGRAPRRPDRRLLAVFM
                     VGAVIGLLMVPEGLAAPYASAVGGASFTVGLLMAADPIGGVLGGWWAARSTREVTPRSV
                     LVPAVFSGIPLAACAVVPGYVLPMLLWASSGALSTVFLVRLQVVITEVVPDECRGGVMG
                     RFSTCVTVSQGVAIAGAGVVADGGAGPVWTVAFAGVLASVWVVVAGFVWCGARPRRARC
                     AEDEHPSSTDGSDLLVTHRGLLPRRPAVGGVNDSQSRSARADALRGNGK"
     misc_feature    13395..13397
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14638..15816
                     /locus_tag="HUW46_RS22335"
                     /old_locus_tag="HUW46_04422"
     CDS             14638..15816
                     /EC_number="2.7.7.65"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00254.1"
                     /locus_tag="HUW46_RS22335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04422"
                     /product="GGDEF domain-containing protein"
                     /protein_id="WP_215549120.1"
                     /transl_table=11
                     /translation="MLVDLAALAVIAAGPFEVRRWQQLALCGGIVACGLVAAELAREVE
                     RRRRWFAGVPHINFSSVWTLAGALVLPPALAGLVAAALYGHLWLRCTAHLPGMRLSRMV
                     FNASNVVLSCQVAAWATEATGLWPFALDRGAAMLACLLLVVMLYYATNSAIAAITVALV
                     STERSFVLLMGPLHENMLELATLCIGAIAGLIFETVPPLIVLLFLPLYALHKSALMRQL
                     EHAATMDTKTGMLNSSNWHAVANAELKRARRDGTELGILMIDLDYFSRVNDTLGHQAGD
                     DALSAVARQIRKTVPRDDLCGRFGGEEFVVVLPCCDAERTREIAERVCRAVADLDVVAT
                     AANTVFSVTVSIGAATYPGRGTELSDLLFAADLALYASKDAGRNRVSMLDPS"
     gene            complement(15824..16225)
                     /locus_tag="HUW46_RS22340"
                     /old_locus_tag="HUW46_04423"
     CDS             complement(15824..16225)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013777.4"
                     /locus_tag="HUW46_RS22340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04423"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_215549121.1"
                     /transl_table=11
                     /translation="MTDLVPDEDIPYRQAVLEGLRVTRGDWTVAVLSTLALGKLAYSDI
                     VDSVNATEDRIGWRSHDRPLSNRVLTNTLRRLEEDNLVARTEKGGRGRTFDGVDYQLTE
                     AGQELLIALRPLASWAEKYRGARSSTPKA"
     misc_feature    complement(16263..16275)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: strong, score: 25.59"
                     /tool="antismash"
     gene            16596..18872
                     /locus_tag="HUW46_RS22345"
                     /old_locus_tag="HUW46_04424"
     CDS             16596..18872
                     /GO_function="GO:0043531 - ADP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="HUW46_RS22345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04424"
                     /product="NB-ARC domain-containing protein"
                     /protein_id="WP_215549122.1"
                     /transl_table=11
                     /translation="MSIDSFAAEVRRRCRRQGVLVRELADRTTFSRSHISKVLNGARAL
                     SGELAREIDAALDAGGALVELALSEIDAPVAPPRPRQLPPVAATFVGRERCLAAFDRVA
                     AAARHSGQAAVIAIEGGPAVGKTTLAVRWAAQAADLFEGCLFADLRGAAPGQPASPEAV
                     LDQFLRALGVAPDAAGTTVEERAATYRSLVMQRQVLVVLDNAASYEQVKPLLPAASVAV
                     VTSRAHLSGITLDAGGTTTIVPPLTSQEAVSLLRMLIGHARVEADQGSAELVVRRCGRL
                     PLAVQIAGEYLQLHPNETLAAMAERLAVGRRRLDVLTSADEQISVRRVLDLSYFALPPT
                     AARMFRLLGICPATMVSVPAAAALAGIPIEQATRLLDVLRLGHLLDLDDTGPVPRYHMH
                     HLLRTYAGEQAVVEEHLSDLERARDRLLRWYVATACAASRAITPSWPSDGLRVRVDDIT
                     PLRFEHHDGYRAAITWCDAEVHTAIALARHARTQLFVDLGWKLPCALLPYLYMAKSWSA
                     WLSAADDAITVAETIDSDTGRSYALLALGWIHHELGHPEEALVHLRRAHDTQPRDGDPG
                     VLVWIAFALAAVHTSAGRHRDARDCYHDAINSVTASGTPDSGGHDHALAVLQAMLATTR
                     DILGDHSGADRALTDAFTRARRLGYPSVLGLLHHRRGLLQMERGQHHHALDDFEDALRH
                     RRAIGARWAVAETLLAYGSALAELGSQERAALALADATSILDELNAPRTRGPRIALTAA
                     SANTA"
     misc_feature    18926..18946
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.85"
                     /tool="antismash"
     misc_feature    complement(19147..19161)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.93"
                     /tool="antismash"
     gene            19152..19631
                     /locus_tag="HUW46_RS22350"
                     /old_locus_tag="HUW46_04425"
     CDS             19152..19631
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015928.4"
                     /locus_tag="HUW46_RS22350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04425"
                     /product="peptidase inhibitor family I36 protein"
                     /protein_id="WP_254126634.1"
                     /transl_table=11
                     /translation="MTSIAARSAVVLAAATASTLPAVMAHATPARPPLTPVAPGSASAV
                     ASQVNKDIIASGQESGVVDARVAGGWDRCPAGFICLFDFCDGQGKMAYFKWRSPDLRAQ
                     GMNDMTSAVWNRADADFDLYEGYNYTGLHSRFDRGMRVNLSWWGGDNFDSSLRRR"
     gene            19799..19996
                     /locus_tag="HUW46_RS22355"
                     /old_locus_tag="HUW46_04426"
     CDS             19799..19996
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04426"
                     /product="hypothetical protein"
                     /protein_id="WP_215549124.1"
                     /transl_table=11
                     /translation="MEQLILGAAADLAAEHRDRRITLDEVAAVTGLKKHHLAPYRSALA
                     TLAEPAFSPSRTRPTSREVG"
     gene            20001..21113
                     /locus_tag="HUW46_RS22360"
                     /old_locus_tag="HUW46_04427"
     CDS             20001..21113
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: ksIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF020130.4"
                     /locus_tag="HUW46_RS22360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04427"
                     /product="3-oxoacyl-[acyl-carrier-protein] synthase III
                     C-terminal domain-containing protein"
                     /protein_id="WP_215549125.1"
                     /sec_met_domain="ksIII (E-value: 1.2e-61, bitscore: 207.6,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRCHDVHLLGFGAALGELVPITSLRTRTRRHSAAAAGQRAVSVAR
                     GQSGPQLAVRAARHALDTSTLLTGSPAAPPDMLLHSSIWRGGKGVDFWNAATYVSHQLD
                     LGAGRGLNAELNLMSNSMIGGLELAASILAGRPDHDTILLTSGDTFGAPAFPHLGTDIG
                     TSYGDGGAAVILGRRPGAFAQLLAIASYSDPTLEALHRGDTGFSPPGSVELAAIDLVAR
                     KRAYLATTTTESVHRRNAVGVIESVKAATGEAGVPLDRISWAVLPHYGKDLLASQCLQP
                     LGIPADRTLCTVGDQWGHMGAADQIAALTHLFTRRVVRSGEHVLVLGVGVGMTWTAAVL
                     RIDNTDTDPAALARFAPPLLWSPQLRQKAG"
     misc_feature    20844..20846
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            21271..21690
                     /locus_tag="HUW46_RS22365"
                     /old_locus_tag="HUW46_04428"
     CDS             21271..21690
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04428"
                     /product="hypothetical protein"
                     /protein_id="WP_215549126.1"
                     /transl_table=11
                     /translation="MIFLPKHASRKRGAVTALTLTAVAAATALATTPASAASSPNAGDL
                     PPAAASAHHDRPAGQEQARLNGPDYWVEGNSVRLRARPIDGPVLNVLHQGNGLDPLCWW
                     NWDGDPWLRAHAWGGATGYVHWRLVHIGAARPGRC"
     gene            21868..22125
                     /locus_tag="HUW46_RS22370"
                     /old_locus_tag="HUW46_04429"
     CDS             21868..22125
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04429"
                     /product="hypothetical protein"
                     /protein_id="WP_215549127.1"
                     /transl_table=11
                     /translation="MADYTLGCGHAQPFEDIDETYLDDSAVDSVLAPSHLWCRHCQRWS
                     PVTAFTTDTPGTASDDTGTHAEEASTTVPIGTCVHKGQTR"
     gene            complement(22134..22781)
                     /locus_tag="HUW46_RS22375"
                     /old_locus_tag="HUW46_04430"
     CDS             complement(22134..22781)
                     /EC_number="3.4.23.43"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637927.1"
                     /locus_tag="HUW46_RS22375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04430"
                     /product="prepilin peptidase"
                     /protein_id="WP_254126420.1"
                     /transl_table=11
                     /translation="MQHPTSWWIAGAAAVGMVLGVSASVLTRRFLPHGRRQVAGSWWLG
                     GVLTATVLAILAWRVGARGELAIYTVVVIVGVPLAVIDWCEHRLPRALVWPQLAGAVAG
                     FVVLAIARGESASGLRALAALGAAGMFFLVLAVVSNGGLGAGDVGLAAVVGLVTGWSGW
                     PQVLGALLVASLLAMVLIVVPGAHRGDDEDRLAVPFGPCLLGGALAMVAIGG"
     gene            22800..23579
                     /locus_tag="HUW46_RS48395"
                     /old_locus_tag="HUW46_04431"
     CDS             22800..23579
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS48395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04431"
                     /product="hypothetical protein"
                     /protein_id="WP_254126422.1"
                     /transl_table=11
                     /translation="MTFAYAIVPARREGLPTLSPTSELPTQSALRHGATATVGPGAGSP
                     LRLDVKGLAARAVQQPSTNSGTVMTLHRSTRLALVVLAASGLTVCACSADDDTTPVPPT
                     SPAPPAVASTTRAVAADSAKQAAIAAYLGMWNDMADAAVTSDWQSPKLAGNATGEALET
                     ISRSLYADHYNGLITRGRPANYPAVATVQPGDKPVSVTLTDCGDSTNWLKYRADNGQPA
                     NDGPGGRRHIDAVVKKAVDGSWKVTTFAVHEVGSCAG"
     misc_feature    23887..23902
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.04"
                     /tool="antismash"
     misc_feature    complement(23887..23905)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 24.8"
                     /tool="antismash"
     gene            23888..24577
                     /locus_tag="HUW46_RS22385"
                     /old_locus_tag="HUW46_04432"
     CDS             23888..24577
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04432"
                     /product="hypothetical protein"
                     /protein_id="WP_254126429.1"
                     /transl_table=11
                     /translation="MRTVRHDREPRETGATRWVSLTRQYPVGAVLAQSPGQGGGWYVYQ
                     CGGGTRDALYRSPVWIPDGQTPGAAPSPEQLAQQARSQLRLPTPVIASSPAGMQLVRLP
                     TWLWLDRAMWAARSATASVPGVSVTATATPTSVSWVMGDGGTTSCAGPGTPFPEHGGDP
                     QAASPDCGYTFRRSSAATPGERFTASATVHWRIAWAGAGAAGTFPDMTTSASSAFRVAE
                     AQALGTG"
     gene            24705..25406
                     /locus_tag="HUW46_RS22390"
                     /old_locus_tag="HUW46_04433"
     CDS             24705..25406
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156824.1"
                     /locus_tag="HUW46_RS22390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04433"
                     /product="SAF domain-containing protein"
                     /protein_id="WP_254126431.1"
                     /transl_table=11
                     /translation="MTSTDTPARGPDADRSASWLDSTGAPARTRGHRSRRLPHLLIGVL
                     LVVVCVGAAVWWTASAGDRMPVLVLARPVTVGQALVAADLRRGDVAVSTGIATVPADAA
                     SAVLGRPMATSLAPGALLTPDSVSAAFSPPAGRAVVGIGVKPGQFPTGLAAGNAVTVVA
                     ARAASSAESGSPNSAGAGTAWPATVTSVAPAETDQLTVVSLEVEAAAAIGLAQQPSGQL
                     AVVLRPAGGER"
     gene            25406..26332
                     /locus_tag="HUW46_RS22395"
                     /old_locus_tag="HUW46_04434"
     CDS             25406..26332
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637922.1"
                     /locus_tag="HUW46_RS22395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04434"
                     /product="carbon monoxide dehydrogenase maturation protein"
                     /protein_id="WP_215549129.1"
                     /transl_table=11
                     /translation="MLIALTSLKSSPGVSTLAVTLAQRWPQADLTRRIVAECDPAGGDL
                     AMRFGLDPAPGLVSLAAAARRASGPAVVWEHTQLLPSGARAIVAPPGGAHARAALHTLI
                     TAPDGPLLDATAAEPGVVVLADCGRADPGSPAEAIARQADALLLVSGARGEDLAHVATR
                     LSELARWTPRPGLLLSGQGYPTPEIERELGVPVMGRIPHDPRAATHHGDTPGSAESGLP
                     RFAAALARILAAPPPPTSTPRSGLPPSIPGVPDRRLRDPGRPLTGPPHTPPTPSPPPGT
                     PAPCPPPWNAYGDQPRQPGDTGREVTP"
     gene            26329..27687
                     /locus_tag="HUW46_RS22400"
                     /old_locus_tag="HUW46_04435"
     CDS             26329..27687
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637921.1"
                     /locus_tag="HUW46_RS22400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04435"
                     /product="ATPase, T2SS/T4P/T4SS family"
                     /protein_id="WP_215549130.1"
                     /transl_table=11
                     /translation="MTPPEADDVSGRAQARLRAVLREALTRDLSHRIDDATAQAGPSVS
                     ASQRRDVARAVLDTARTAHTEAELLAGRALLDTATEQQVTEQVLDEVFGLGGLQPLLAD
                     PAVETITVNRYDRVFAQYTDGRRAQVAPVAASNDELTDLIRTLAARASSEERRFDRGSP
                     ALNLQLPGGERLFAVLGLTAGGVTACTIRRHGYLTATLAQLRRRGTLDAGLERFLRALV
                     RARRNVLITGGTGAGKTTLLRALAAEMDPMERLVTIEDAFELGLERDPALHADVTALQA
                     REPNIEGEGAVDQAELVRWGLRMSPDRVIVGEIRGAEVIPMCNAMSQGNDGSMATLHAS
                     SSKIAFTRLASYAAQGPERLPLEATALLVASAVHFVVHLDRAADRGTRVIASIREVVDA
                     EDGAVISNEVYRRGADRRAVPVAGALRTDTLDDLVAAGFDPDLLARREGWWAP"
     gene            27684..28622
                     /locus_tag="HUW46_RS22405"
                     /old_locus_tag="HUW46_04436"
     CDS             27684..28622
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020637920.1"
                     /locus_tag="HUW46_RS22405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04436"
                     /product="pilus assembly protein TadB"
                     /protein_id="WP_215549131.1"
                     /transl_table=11
                     /translation="MSIDTTAPLAAVLGVGTALGVLVIVAAWRRPAAAVSPPPARRAGL
                     VRTARGQTVDRRALARVVVALGVGALTGALTGWVVGAVLAAATVWFLPRLVGPDHAHQR
                     RVARIEAIASWTEMLRDVLSAAAGLEQAILATVSLAPAAIRGEVAVLAARLESGQRLAP
                     ALRALARELDDPTADLVLAALVLAAEHQARQLSDLLGSLASTARGQAAMRMRVETGRAR
                     TRTSVRVIVVTTAIFAAGVVVFNRAYLDVYNTATGQIVLLLLGGLFAAGFAWLARIATS
                     AGQARVLALNAPGGIGAPNGGEIVVGGGERA"
     gene            28619..29512
                     /locus_tag="HUW46_RS22410"
                     /old_locus_tag="HUW46_04437"
     CDS             28619..29512
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663628.1"
                     /locus_tag="HUW46_RS22410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04437"
                     /product="type II secretion system F family protein"
                     /protein_id="WP_215549132.1"
                     /transl_table=11
                     /translation="MIPALLFGAGAGAGLWLLLTWALPPSPALSDRLAQVSARPPATPI
                     IAAAEATWVCRWGRVFVPGLRKLGLPGTKIEADLRVIGRGVDTHLASKALLAVAGLLTP
                     WLLQTLLVLVGLPLGVEAPLLAGLVCAALGFVIPDLGVRTKATRLRREFRDALSAFLDL
                     VWITLAGGAGVEAALGDAAAVGAGPAFDKIRRALHTAQLTRTTPWNTLRRLGEELDITE
                     LAELAASVSLAGTEGARVRASLAAKAQGLRTHQVTDAESDAQAATERMALPVTVLFLGF
                     LGFITYPAVTQVLNGL"
     gene            29579..29779
                     /locus_tag="HUW46_RS22415"
                     /old_locus_tag="HUW46_04438"
     CDS             29579..29779
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156819.1"
                     /locus_tag="HUW46_RS22415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04438"
                     /product="hypothetical protein"
                     /protein_id="WP_215549133.1"
                     /transl_table=11
                     /translation="MLHYIRIVWELTRTRIALLRAAPERGEITTTVIVIAVLAIAAITL
                     LAFIVAKLTRKVNSINLGLGG"
     gene            29782..30231
                     /locus_tag="HUW46_RS22420"
                     /old_locus_tag="HUW46_04439"
     CDS             29782..30231
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156814.1"
                     /locus_tag="HUW46_RS22420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04439"
                     /product="TadE/TadG family type IV pilus assembly protein"
                     /protein_id="WP_215549134.1"
                     /transl_table=11
                     /translation="MPTKAVRTSSTRVRALVERVRRALRGDQGEATVELVIATPLLLLA
                     LLAIIQFALWSHATHVAQAAASQALAAARTQDGTTSSGHAAGQRLLDELAAGPLRDPSL
                     AVSRGAAAVSVSVRGEAAIVLPGVHLPVHAEASGEIERFVPDTAP"
     gene            30282..31262
                     /locus_tag="HUW46_RS22425"
                     /old_locus_tag="HUW46_04440"
     CDS             30282..31262
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04440"
                     /product="hypothetical protein"
                     /protein_id="WP_215549135.1"
                     /transl_table=11
                     /translation="MSHHNPPVTAMPVRAATFPDGPDSVLLNPDIPRARWRGERVHAGL
                     RHRFVLTGLAGAALAPLTAVSCSGFAAVFFLGAGILALGMSLLAGWCSAAGMLTDHRHP
                     ADSPCRLDRVRGEFFFRSRDFTDLGTASYAVRTLIAGVDELHRSPARAWIDPAVPREVH
                     RVVWQALCCLDRTRAARSLADELAADPDSAVGELAAAAREAVTVIDDALDDVVRHVHGC
                     LVLTRAWEAKLRHSELTTRTDHTLAALPGDTEVQQLAQAAEALPQNVFAYVTAARDITG
                     TGAFPWEQPTSAWSRLLRNLPRGRSRGRPSRRAQARRARSGEELS"
     gene            31259..31729
                     /locus_tag="HUW46_RS22430"
                     /old_locus_tag="HUW46_04441"
     CDS             31259..31729
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499952.1"
                     /locus_tag="HUW46_RS22430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04441"
                     /product="TadE/TadG family type IV pilus assembly protein"
                     /protein_id="WP_215549136.1"
                     /transl_table=11
                     /translation="MTGRAPKEPTVWVRRWWAAERGSVTAEAVLVTPLLVMLLLFVAVV
                     VHRGVDARLRLDDAAHQAARAATLHRSTTTATSAARDTARAALARAGLVCRDVTTTMSG
                     TLVPAGAVTVRVRCTVDFGQALLLGVPGGKTLDATASEVVDAYRSSHQGAGA"
     gene            complement(31738..32265)
                     /locus_tag="HUW46_RS22435"
                     /old_locus_tag="HUW46_04442"
     CDS             complement(31738..32265)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04442"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_215549137.1"
                     /transl_table=11
                     /translation="MTAPQTQDSPVAYEDSLTAWHEAGHAVVYLLQGRSLRYVTLRPRT
                     AGRAGFTAVRPRRVDPSALAVVAHAGPLAQARHVLDTTSTVERRREDITAEDVRLDAYL
                     HGGHDDLAVIAEARRAYGLPTRQPDLWAGIAQDLIDRYWTEIGRVATGLLEHRTVTGAQ
                     LRACVPGHWLAR"
     gene            32365..32754
                     /locus_tag="HUW46_RS22440"
                     /old_locus_tag="HUW46_04443"
     CDS             32365..32754
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499951.1"
                     /locus_tag="HUW46_RS22440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04443"
                     /product="pilus assembly protein TadG-related protein"
                     /protein_id="WP_215549138.1"
                     /transl_table=11
                     /translation="MTAFVLALLIGLLALTGLSLDGGLALASKVRAGGHAESAARAGAQ
                     ALDLAAYRASGVVRLDPGRARDLAQRYLASVGATGTVALAGDTVTVDVTATYRTQLLSL
                     IGIESIHTHGRGAAHPQRGVSGIEP"
     gene            32791..33222
                     /locus_tag="HUW46_RS22445"
                     /old_locus_tag="HUW46_04444"
     CDS             32791..33222
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663112.1"
                     /locus_tag="HUW46_RS22445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04444"
                     /product="hypothetical protein"
                     /protein_id="WP_215549139.1"
                     /transl_table=11
                     /translation="MVTSEDEITRRLQERDSARSARREKAATTVGELARRHAELAGQLA
                     DLERELGEVLTAAGEDIDVPELAQVTDVPAADLTHWRDQAAKPARGGKRSRPSAKKNTT
                     PGKGTQAAAEPRAAHPAAPAPAAPESVGVGGVAVGAAST"
     gene            33222..36185
                     /locus_tag="HUW46_RS22450"
                     /old_locus_tag="HUW46_04445"
     CDS             33222..36185
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663111.1"
                     /locus_tag="HUW46_RS22450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04445"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_215549140.1"
                     /transl_table=11
                     /translation="MAPARRTGIARVVSLLGRAVRGLLAAILLVTLVAGLPVALIYGVG
                     WPLPDHLPNMDEIGSALLSPMSTSLLLDTLACLAWLIWLVFVIEVASCAFDVARGAWRP
                     ELRLQSGPVRRVAAVLVSALLVALLGRTAAPAEGARPVGHAPVVVTALARPPAVSGEHP
                     GTPPPQSTAEPGTERVRLPAGGVHDSLWRIAQRCLGDGDRWPEIWALNDGSPQPGGRVL
                     STPNLIHPGDTLRLPVTSPPPAVSPAAAPPAPGPTSPAPAEPAHPPLPTTTPPPSTPAP
                     ATTDPAAGPAADRPAGGAVTWGSGEVFVSVGLAAAVSALLVLARRRRQARYRPGSGRRD
                     DDLPVAPVVYQLRLAHLRTQHHDEDTDLEAETLKAETDEAGDPETDDSARHEDRHDPAR
                     VGAASRSRRADSGPERRVRVHAPRVRRVVGAAAPTGAGPAQPPSVVDMAIDTTGRRAGG
                     GNADATGEGAQVAFDLARAHGLGVVGPGGYAAARALLLTMLTTVSEGGPAPRVVVPAAD
                     LARLLGVPVPATGVPEAVTVVADLDTALAALDAPQPPRPAVLIAAPPHETGQQARLQQL
                     LDNNAQYGLTALLLGQWRPGVTAYVTAAGIISATDPGLGEPLRGTRAFTLPETATRDLL
                     AFLRAARPRDVAEPHAPAPDQTSMPSEEVTPSPPERSGDGSNHLEITAGPVTPEPDSAE
                     ADGEPGGGPLPRTPRTADTAAGTPAPLVLTVFGAPALHWRPDPARPEDTRDLSGEFSSR
                     PVELLVYLAVHPGGASRDGIVDALWPDEPPRNPASVLRTVLSRIRRALDTATRGAVGEL
                     VMAEHGQYRLDPAVVEVDYSDFAAAVTARRTATTPERRTDAYEMIVAHYGGFLAEGLEA
                     EWLVAAREATRRDALDAVAALARARVTDDPDYTLDLLEAARAFDPHNELLYRDIMRLQH
                     VLGRHEAISRTLDLLRTRLSEIDTRPTADTVDLAQRLRARDTGISVDEFSVSRSTAP"
     misc_feature    33543..33545
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(36401..36414)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.19"
                     /tool="antismash"
     misc_feature    36820..36836
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.54"
                     /tool="antismash"
     misc_feature    36823..36836
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.24"
                     /tool="antismash"
     misc_feature    complement(36823..36839)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.65"
                     /tool="antismash"
     misc_feature    36824..36833
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    complement(36824..36837)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.35"
                     /tool="antismash"
     misc_feature    complement(36824..36838)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.0"
                     /tool="antismash"
     misc_feature    complement(36825..36838)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.25"
                     /tool="antismash"
     misc_feature    complement(36826..36839)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 19.43"
                     /tool="antismash"
     misc_feature    36827..36840
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.79"
                     /tool="antismash"
     misc_feature    complement(36928..36946)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.54"
                     /tool="antismash"
     misc_feature    complement(36959..36973)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.13"
                     /tool="antismash"
     misc_feature    36960..36974
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.73"
                     /tool="antismash"
     gene            37109..37351
                     /locus_tag="HUW46_RS22455"
                     /old_locus_tag="HUW46_04447"
     CDS             37109..37351
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04447"
                     /product="hypothetical protein"
                     /protein_id="WP_215549141.1"
                     /transl_table=11
                     /translation="MDYIKPFTTTENGETVMCYPVTFDGRKITVTGPDGPRTRTRRART
                     GYATAATLRAMGYNDLRAVCPDGTADVFGFTTRAN"
     gene            37426..37749
                     /locus_tag="HUW46_RS22460"
                     /old_locus_tag="HUW46_04448"
     CDS             37426..37749
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009156807.1"
                     /locus_tag="HUW46_RS22460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04448"
                     /product="hypothetical protein"
                     /protein_id="WP_215549142.1"
                     /transl_table=11
                     /translation="MNHNANDPRPVYVIDPDADPGPVPEVVVRSDIENGCTVTGVVIDP
                     ADAQQVLYGTVTRPDGTFAGSYYPADTLRGDHWRVVTADGKHYHATSEYHAVDALVNGF
                     TAS"
     gene            37780..37980
                     /locus_tag="HUW46_RS22465"
                     /old_locus_tag="HUW46_04449"
     CDS             37780..37980
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS22465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_04449"
                     /product="hypothetical protein"
                     /protein_id="WP_215549143.1"
                     /transl_table=11
                     /translation="MTHTDTTHANENDQPETGIVECGGCSRPLEVTRQQWESWASLPCP
                     CGSAADLNFARRHCEWGESLM"
     gene            38046..39209
                     /locus_tag="HUW46_RS22470"
                     /old_locus_tag="HUW46_04450"
     CDS             38046..39209
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020663110.1"
                     /locus_tag="HUW46_RS22470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04450"
                     /product="AAA family ATPase"
                     /protein_id="WP_215549144.1"
                     /transl_table=11
                     /translation="MTTPATTPATGSTPAAPGAAPHRLRNGELRRMVAEQLAHDPAAAL
                     TPGAIATKLGRSSGAVGNAVATLESRGEAEKIGTNPVTYRATAKTADAAKTPTVAPRGT
                     TATPAPPKPAPPPAPAPLVTDPVRRPNGQMYHPRKLSALSDVTALRRLREANVSALMYG
                     PPGTGKTSVVEAAFDDLITIQGDSDTVTDDFVGSYTQTPDGRYEFAYGPLVTAMRDGRA
                     LFIDDATLIPPTVLAVVYPAMDGRRQIIIKTHKNEVVDAAPGFYVVAGHNPGVHGAVLT
                     DALSSRFSVQVHVSTDYDLATQLKIDARAVRVARNLAQRQGKGEIGWAPQLRELIAFNR
                     IADVLGIDAAAGNLVGIAPEEDRAVVAEAVRNVFGANLAPLSLGPQF"
     gene            39256..41019
                     /locus_tag="HUW46_RS22475"
                     /old_locus_tag="HUW46_04451"
     CDS             39256..41019
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499946.1"
                     /locus_tag="HUW46_RS22475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_04451"
                     /product="VWA domain-containing protein"
                     /protein_id="WP_215549145.1"
                     /transl_table=11
                     /translation="MSTHVATPTATPTAVFPAAPAWLTLSAAFGDEVPAIADRDDLVIT
                     VAPGAGHGAPACFFPDFATIEVDGSHMDKGVDPATVEPHRVGDRKRYRTAWGLLTHECG
                     HAKHSVWRVPDDAPPGAVAAADLLEETRMEAAQVRRRPGDRYWLRASAANLILADTKAN
                     DPVAAPQMTPQDAARSAALLLARVDEGILNRREVIRVERVVRDVLGTDTLAKLRTIWRA
                     AHRTADDNATRMIELGRKWCETIGTDPNQPADTPDPNATNNANGNGNGAPSPLASAITS
                     AAAAIGIGVATEPAPTDPVTQAMDARAADDNARQQAQRDANRVFGGVGTGRDRTARHIQ
                     GTRMPSTTERTAARQLARALTTAGNRDRTATKTRSTVPPGRLRMRGAMTADAQRAAGAM
                     PTAEPFTRTTRATVPAPPLRLGIICDVTASMAAFTAPVASAAWILAHAARHTAVPADTA
                     TVTFGAGIVTPITRPGVTPSKVTEFGTRQGGHVIDTAINALDGALDLSRPTAARLLVII
                     SDGMFEATTRNPGQKMLDRLRASGCAVLWLAPNTSAIDPMNGATVHTLTNPTTTARAIG
                     QAATAALRATH"
ORIGIN
        1 gggtccgcta cccgatgttc ggtgccgcgg cggccaacat ccggccgtgc gccttctggc
       61 cgtccgcgcc ggtcgaaccc ccggtgcgga tcggcggcga cggaccgtcg aacgtgctca
      121 tcgcgcagaa cctgcgcgat ccggcgaccc cgctgagcgg cgctgaggag atgcgccggg
      181 cgctcggtga ccgggccagg atggtgaccg cggaccaggg cggccacggc acctacctgc
      241 tcgggaagaa caagtgcgcc acggaagccg tgaacgcctt cctcaccacc ggaaaacggc
      301 ccgcggacga tatcgcctgc gccgcggaac cggcctgacc ggtccacttc ggattgtctc
      361 gttcggacag tccgcggcgg gtgacctggc tgccggtcgg gggcagccag gtcacccggc
      421 gatcagctgg ccttcttctt gcgggccgcc cgtttgcggg cgggcttcgc ctcggcctcc
      481 gcctcggcct gctgggcctc gtcgtaggcg ttgatgatct ccgcggacag gcggccgcgc
      541 tcggcgatgt cgtagccgtt gtcctgcgcc cacgcgcgga tctggcggtt gcgctcccgg
      601 tccgtcgacg aggtcgtggc gcttccgcct cccgcggcgg actgcccggt cgcgagccgg
      661 accttgcggc caccggtgcg gcgggccgcg gcgatgtagg actcgaactc accgcgcagc
      721 gcggcggcgt tgtcgtcgga caggtcgatc tcgtagctga cgccgtcgag cgcgaacgga
      781 accgtctgcg acgcttccgt gccgtcgatg tcgtcgagaa tctcgacaag aaccttctgg
      841 gccatactgg tcgttcctcc tgacaagaca ccgcgtgcag ggaggtggcg gtgtcaccgt
      901 gcgcagggta acccgaacgg cccaacggcg gcgcgaacac cgcaccgaaa ccgcgatcac
      961 cagccgagat ctccccggac cagcgcccgt tatccgaatt cccgatcgtg cccgacacgg
     1021 atttcgcacc tcagaggcgc gagtgaaaag cggactcgga acctcgtcac cacaacgatc
     1081 cgcgccgtca cctttcgcgt ccggaccgtg cctcccagcc agttcgccga cgcccgaccc
     1141 gccgatcagg atccaccagc gaccctggcc gcgtgatgcc caaccgccgc ccgctaaact
     1201 ctgcacacgg gccgctagct cagttggtag agcaagggac ttttaatccc cgggtttgcc
     1261 gtgttaacga gtgttgcata gtgtcgccca aggttaatct gtgcaggtca gaccacattt
     1321 tccgctgacg ttaatgttgg gcagtgtcgc ggcgtatcgg gcgctctgtg agcaacggag
     1381 cccaaacgga gaccgccatc ggcctgcggg cgaccgccgc acgagtcggt cggagaaact
     1441 cacaccgtag ctgcccgcga cccgttccag cgcgaaggtg taggcagcac cgggcagtat
     1501 tgctaacacc gcgaccggca gccctcggaa ggtggagatc acgttcgccg caccccttcg
     1561 ggccaggtga tcagcacgtc gcggtggagc ttgcgggcac gggcgaccgc gtcgccagtg
     1621 ccaccgaggc cgtgcgccgg ccgcccatcc cagactgcga ccagcagatc acagtgttcg
     1681 accacgtact tcccagcagc atcgaaggcc ttctcactgg ggctggggaa gtcgagttca
     1741 gtgaccgtgt gtgcggccgc gcgcagcccc aagtaggtgg tcaggtctgc gccggtgaag
     1801 gtttcctggt agctgcggca ggggattacc gcgtgcaggc gatgcccggt ctccacaagg
     1861 agttcggcga acaggtggtc cgcgcctgca gcgagactgg acagcccgat tacccggccg
     1921 acctggcggg cgagcaacgc gcgtatgtcc ttctcggcgc gggctcgtgc cagggcgggc
     1981 agattctggt gcccgctgac tccgatggac atcacagcat tccctgcttc gccatcagcc
     2041 agtagtgttg tcccagtgcg gtcagcttgc agcttccgct ctccatcgcc gcgaagtaca
     2101 tgtgctgatg atccacgggc tcgaccagct tgttcgcccg gcacgtctgc aactgagtga
     2161 agatcttctc gtgctccgga tgggggtcca gcccggagca cgacttgtcg ggctcgaagc
     2221 tcggatcgag cgggaagtgg tactcaggca cggggaacca ttcgatgagc ttgcgcagcg
     2281 tggccagcgg cggtgctgga gcacatcgtc gcaggtcgtg tagtcggtcg atgttggcct
     2341 tgaacgtcgg gcgctgatcc cacgggccga agcattccga cagatatgcg tacagcccgg
     2401 cgacggtgac gtggccgagc acgtcagccg cgccagcgtc gagcgcaccc tcaaggtgag
     2461 tggagaacag tccgcggcca ccggactcag cggaggtctg atcactgcgg ctggccgtca
     2521 gaatagacat gccgctgcgc agcaccgctg cattcgtgag cgccgtgacc gtgcctgcac
     2581 caccagcgaa gcagcagtcc aagatcacca ctatttcctt gacctgcgag ttcacggcga
     2641 tctccaacac ctcagcgaac cggactccga gtgtctcctc gtcgccgtcg ctggtcacta
     2701 gggcgacgtc gccggccacg agcatgccgt gaccggcgaa gtacagcagc gcgaaatcgg
     2761 cgccatcggc caacagttct cgaacgcggg tcaacaggtc gcgccggttt accgtgccgg
     2821 tcaacagccg gcaggatagg ttcgcggtgt agtcctcgtt acgcgcgagg agcggctcca
     2881 gtgctgtggc gtcgttgaca cacccactca ggtcctgcat gttgtcgtag tggtctatcc
     2941 cgaccagcag agcacgtcgc atgaggtcaa aggccgtcga tgaacgaggt gaccgcctcc
     3001 cacgtccagg gcacgcaccg tgacatgccc atttgggtcg gcttggtccg gtagccgtcg
     3061 tccagccaga tccccagcag cggcttatct tcttcgaccg cgcaggtgat ctcccatagc
     3121 tgccccgtcg cctgcggggt ggcgcgtgag atcaagacga tcaccccacg ggaacgaacg
     3181 atcctagtac ggacccgctt cttccactcc gtctcgtaag gctccttcac cgacatgtcg
     3241 gtgaactcga acggagtcct cgctgacaca cgctggcccg tgaacaggtt ccgccgcgcc
     3301 tcgtcttcct tggcgaaggc gatgaacacc gtcttacgat ctgccatccc gatccctcac
     3361 tccatcctcg tcgcggtgat gcactacgcg ccaccgtcga tggcccggcg ccgtacccga
     3421 aggcaccgac aaaccactca acgtcgcccc tggacgaaga ggcgcctgcc aatagtcagt
     3481 agtcgtacag aagatcgtcc gcgtaacaca gccgctaaca gatcaggtcc tggagggctc
     3541 acctcgcacg aacgatgtgt cctgctgatc ttgaacatgc cggtcacacg gcgtgaggtg
     3601 cccggcgcat cgtggcgaat catgccccaa gccggggcgc acgtcgtaat cctgaccgcg
     3661 tacgccgtgg ccgagggcgt gtttaacgca ctgcgcgcgg gcgctgtcga cttcctggtc
     3721 aaggacaccc agtctgggga cttcctaccg acgtgccaga attcgatcaa ctcggcagta
     3781 ttattccatc tagcttaaat aagatgtagt gcatctgcgc gacatctcat catcattctt
     3841 catcgcaacg tggacacgaa tcaaagatga ttcgacaact cgaagcggct tgatggccac
     3901 cgcgatcgcc agcgcggcga caatctttac ccaagctaca ttggccccaa gtctcccccg
     3961 gcggcttgcc atcgtaattt tcatgatcaa tccattgtcc aaagcacctg cgggaaacat
     4021 gtgaccaatt tgcagcttgt ttggcaactt tatcacgaat agtttcctcg gtctcacgga
     4081 actgtcgatc caactcgggc cgttcgcggc gaagtcgatc catgtcaaga agtggtttaa
     4141 tcatgcacca tggtgacacg caagcatgtt ccttgcgaga cgattgaccg acccgagacc
     4201 cacttgcaac acactacctc ccacgaaaac cacagtcagt tccgcacaga agaccgaatc
     4261 gccaaaccga acagtcggta ctgggtgtta aattaaaccg atttctcgaa ggaaacgact
     4321 cggcgccgca ggctttatcg tgtcatactg ggtaacaaca aagtcatagt agaaaatcct
     4381 tacctcctct cgagcccggg taatcgacac atagaacttt cgcccatcct cggcaatctt
     4441 ggccgaatcg ctacctgaat gatagctcgg gatatttccc tcgttggcac ccacaagtaa
     4501 caccacgtcg aactcaagtc ctttgcttga agtcatcgtg gtgacttcga ctcggtccac
     4561 cttgcgtgcg cgttcagcaa gttcaactat cgaaacccct cgaagaccgc cggtagccag
     4621 cgccaccctc atgcgctcga cttcgacggc gtcgtctgcc atctccattt gcgcgagagc
     4681 tcgcttcaac ccacgctcca taaggctttc cacaaaagag gccgccggct gcgcggagtg
     4741 atcacgaaga ttcatcagaa gttccgtcag tgcgacgttg tcacgacgtg accaactgcg
     4801 cccgaagatc gttcgccacc tttgcaaaag gtcgaccagg cggtaattgc tcgtctcgcg
     4861 tcctagcgtc gcccatgcgg ccgccgcttc gatgaatcct gtcacgacag tgagtcggta
     4921 ctccggactt cgaaagaaga caggaatccc gctatctcga agcaacgccg tcacggcttc
     4981 acactggtct cgtatagtgg ccagaacagc gatctcatgc agcggcacgc cgcgccctat
     5041 agtctcccgc acgtatgcca caagatgtcg atattgttct tttgagctgc caggacagtg
     5101 cacggccgat acctgaccac cggcacgact accgacgatc ggccttcggc tggtgcgcat
     5161 caagttgccg gcctggataa tcgcctcacc gcaccgatag ttgtgctcca gttcaacccg
     5221 agtcacacca ggatactgag cgagcttgtg caacaaatca ggccgtgcgc ccatccactc
     5281 gtacaaggct tggtcggggt cgccgaccgc gaacaactcc gcattcacca cctgatcgaa
     5341 gcaaagcgct ttgacgagac ggtccagccc aggtgccaga tcttggtatt cgtctacata
     5401 gatgtgggga tactgcgcgg tgaggacccg tcggatcggc tcgtgcttct cgacgatctc
     5461 gaccgccgcg gtcacaagtt gggtaaaatc acgcaagccc cgttcatgca gcttggcttc
     5521 gtaccgtagg caagcttcac gaaccttgtc gctatgccga gcccagtcct cgtcacctgc
     5581 gagacgctcc cgatttattt tgatcgtgga gtcaacgtgt ttcttgttat cgttaccaaa
     5641 tacttcggcg atagcgtcct taagcaagct gcggcactgg ttctcactcg cgatcgagat
     5701 attcacgagg tcttcacgac cgaccacctc agcgaacggc gcaatgatct tgccgagggc
     5761 gaagccgtgg accgtcccga cgaacaagtt cgatcggctt tcgaccccaa ggctctcaac
     5821 acgtcggcgt agttcgtccg cggcagcatt cgtcagggtg atgcaggtcg cgccttgggg
     5881 cttcgggatc ttgttgatga ggtcataggc caaccgagta gccagcagtt ttgtcttccc
     5941 gctgcccggc ggtgcgagaa ccacgcagtg cccctgggac gtgaaggcct gccactgctg
     6001 agggttgtgc ttaaggtccg cgatcgatgc ggacagcgcg ctcaccgctg ttccaggtac
     6061 cgaagcgcag cctccacgta ttgaggcgcg tgcaccggcc ggagcgccaa gcgctgagcg
     6121 taccgtcctt tgccgcccgc gtttttgatc atcttcatga actcgtcgta cccggggtcc
     6181 tgcccgttcc aggactcgat cgtcgcaacc gacggcgcct tgcacaactc gctcaagctg
     6241 tcgaacgctg ccgtcatgtt agccggttct tcaagaagat catgctcgaa ggtggagcga
     6301 ccgacgaaga ttccatgctt ctgggcatcg cccgtgcgcc ccaatagctc gagcagactg
     6361 gcggctcgcg catcgccagc ccgtgctccg ctggcagcca catcgccgtc ggtcaggatc
     6421 gcccacggaa tctcaagggc attacacagc tggacgtagg agctgaagtg ggtcccgtga
     6481 atggcacaaa ccgagatacc gagcttgtcg aggtccatgc cgagcgcctc ggcgagcttc
     6541 ggcaccaaca cctgctccgc gaagccttcg accaggagca ctcgacgggc gaagacgagt
     6601 tccgcccggg tggcgtcgag gtagcggccg acgtcgtccc actcaacgtc actgagcgag
     6661 gctcggtgcg ctgcggccgc aacggtctga ccaccaaccg tccgcagcac gaccaaactc
     6721 cgcggatcgg caacgctcgc gatgtgcggc gactgggtcg tcactaggac ggtcgtagcc
     6781 tcctggccgt ccaggaggcc gccgaagacc aaccgctgca ggtgagggtg caggtgcgcc
     6841 tccggctcgt cgatcgccag aaccacatgc gcgatatctt cgtcatcgac ccgccgcgtg
     6901 tcgaggccca accgctgcaa agccagatac agcacattca acgtacccag actggcactg
     6961 ccaaggttcc ggtgcgcgtc gccgtcgacg aacaggcgca tggcgcggat cagccgcatc
     7021 gggtcatccg gcgccgcggc cagctcggtc gctatcgcct gattgtcacc gaccatgtcg
     7081 acgagccgtt ggccgatgtt gtcgctgaga tccttgatga cgtcaagact attcaacttg
     7141 tcattggctt ccttcatcgc cacctgaacc tcgccgaggt cgtcctccga cgccgccgct
     7201 gcggccgcca gtaggagggt tcgcagcggt gaacggcgcc agttccgaat gtcggcttcc
     7261 acatcgcgaa gagcgtgcag gaagaccagg tgtaagtagc tcctcagctc gtaggagatg
     7321 gctcgccccc cgccctcacc gccatacacc tcacccctgt acttcggctt gagcgtctct
     7381 tcgcccgtat ccaccggcgc gtaccggtac gtgaggcgcg ctcgaagcgg atcgtcgtcg
     7441 agcagcgcct ccgccaaagc ggctggcagc ttggggtcgt cttcgaattc gacgatgtcg
     7501 atcgacgctt cgatgacttg tccttgaatc aaggggtccc atccgtcgga gccgtccgac
     7561 aagccgtccc agaagtcctc acgagacaac tgccggtcgg aaaaagacag agtgctatcg
     7621 agaatgagcc gcaaggcgtg gaggaggttg cttttgccag ctcggttctc gcccaccacc
     7681 acggtgccag gaagaagctc gacgtcgatg tcggcgaggt tgcgaaagtt ctttatcttg
     7741 agccggttaa tgcgcatgtt tactccgctg ttgttcacca gtatacgacg gtgcagaagg
     7801 ttcacctacc gcttgagctc ccacctcgct cgtcagcccg tctgacgcct ggtcgtgtgc
     7861 caggccaggc tcgttacgcc gtaaccggtc gaacacccct gaagctactc gatgtgatga
     7921 acctcagccg cgccttgtaa cggccagcgg ccatcgatcc cgtgatgctg ccgcgcgggc
     7981 cagtccgggg aagataccga aagtgtcacc tggtcgcgtt cgttcgacta ggaacggact
     8041 ccgatcatct cgttcacttc aaccaggaag acacgccaag gttcagctgc gtcgtcgcca
     8101 tatcgtttta ggacaacagc ccagcttcgc ataatccaca gccgaaagtc gtcccaaata
     8161 tgctcatttc ccggcggcag caggatttga gcttcaagta cacgatctaa gatttctttc
     8221 ttcgcagcca cttcgagagg ttgctcgtcg gtcgctcgtt gacgcgcgcc gatctcctcg
     8281 aacaagattc ccaacctatc catttcagtc acgcccatac ctgctctctc gtcacagcag
     8341 acgcttcaag gcctgagaca acccaactcc tttggcatgc acaagtagcc gtctgccgcg
     8401 gaccctttga tcgccccatg tcacaattga gtcgccaggg ttcccgtgcg acgcgtagtg
     8461 cttctcgaag tccatgtcct caacatccga ctcgtacacg ctgcggatgg aatgatcagg
     8521 agtctcaaat tggtagacag agccgtcgtc gatagtcaca acctcctcat tccataccgc
     8581 aaccttcttt agtgttccgt ctggcaacag gacaacgtag tgttcttcgt gggtggtttc
     8641 ccgttgactg ccgcgattac cacgcccata tctcgcgttg cgctcaatac tgtgatggcg
     8701 gcgatcaagc acccaatggg gtccgacgac atccacccgc tgattcacgg cgactgtctc
     8761 cgactggctc tcagatcgcg tgaacatctt gaacagaccg tatttgacct ccactcgctt
     8821 tgtcgcggtc tggtagtccg tcttgtggta ggaaattccg ctctcttttg gcttgcggct
     8881 ctcgcgggcg acacgcttgg cctaggcccg gatacgagcc cagtcgattg tactggcctc
     8941 gtatgctcgt ttgtcgggca tggactccct tttcagaacc gagtgtgacg gaggacgagg
     9001 aggcgctgac cgtcgacggt tggccatcgt tggtttaccc ctcgcggact cggctccgtt
     9061 gcgaacccag cgctgtgcac accatgacag gcccaacacc actccggccg gtcgtcagca
     9121 ggccaccgcg ggatcatcca gaacgcgatc tcacctcagg acgaccccgc cgtgatcacc
     9181 gcagccctga caggcttcca cctcgcgaac ttgtcaaagc agggcgctat ttgggtccgc
     9241 tcgttgtcgt gctgtttttt gcggctgtgc ccgcttcgag atcttgcgtg cgcttatctc
     9301 gcttctgctt cgacttactc tcggcttctg cagtcttttt tacagcttcg gctacccgaa
     9361 cgatgggcga cggctcggga ggcaatggtg gcatcggcat ctgttctact cctctgagtg
     9421 atcggttacg ccacaacgtt gacgcaagct gtcaacgacg aggtcgaccc ggacggcgct
     9481 gcgttacgat ttgcatcgag ctgagaccgg aaaggggtca gaccgagacc tggttaaacg
     9541 cgcgagcgaa ctcagcgtcg gtcacaaagc catcgccgcc gccaccggtc gagtagccct
     9601 caccggagag cgccatgacc gggtccaaca cctcggccat gaaatggcgg gtccaatcgc
     9661 tgtagtcctg ctgctcgtga gcgggcgacg gcaccagcag agcgaggctc ccgccccgga
     9721 agccaacgac gccccagaag atccggtaca tgcccacccg gctcatgacc aggccatcgg
     9781 tacgatcatc gtggtcttcg agcaaccgag gtgccgctct gatgatggca cgggtcgtgt
     9841 ccgccgggtc atgcggaccg cacacggtaa tgatcaaacc acttgcgccc accagcttgt
     9901 agagagtctc gacgggcgtg ccacgggcgt gctcgctcaa caccaagtca aacatcgatt
     9961 gctccttagc tttataattt gatcgaacga gccgtagtcg cctgaagcga tggcgttgtt
    10021 acgaatcatc ttccgatatg ccgacccgtt acaacttcga ttacaataaa gcgacagggc
    10081 gctcgtccgg ctctgtacgt ctgtcacaca gtggaaccga tatccgtgac cggttttcag
    10141 cacacctcat cgttcatctt tccgacactg gcctggcaat cgccttctga acccgtgctc
    10201 aagaccaacc aaccgcggat ggccatccgg gcaaccgcga tgagctggca gaacatgagc
    10261 accgacggcg ccatgagcga actcatctcg gccgataact tcaccggtcc gccgcaggac
    10321 ttcaagctca accacgtcaa cgagatcctg ggcctcatgg gcagcaccgg cgagcagctg
    10381 gccctcgcct ggaccgctga acaggacgtt caacgctggc tccagaccgc tacaacccgc
    10441 gaccctgtcc accagcggat gggcgttcgt gctatggctg aacgcccact tcagcctcgg
    10501 tgtagggcac agcctcggta acacggtgct gcgggtcctg gccttgaaca atgaggcgaa
    10561 cgcgtacctt gaggtcaagc tgggcaaggg gaagcggccc ttcacccatc ggccggggtc
    10621 gaacgaccgc tcggcctggc agaccctctc gccgaggtca ccgctcgccc gatatctgcc
    10681 agaaatggcc gaaaggactc acacggcctc gtgcaagcag ctggcagcag tcctcgtcga
    10741 cctgtgccac gcctacggct acgtcgatct tgacgagcgt cgtgggatgg acttccaccg
    10801 ccaccggccc caatcgctcg actccggctc gccgcggtcc ggcccgtgga aggaagacaa
    10861 ggacgctggt tggcgctcct tcgacctgca cctggcgaca cctgaccccg actacgacga
    10921 gcagctcgtc gccaccgtgg ccgccgacgg ccttgaagcc gtggccgccg ctctcaacgc
    10981 tgcgcacctg ctcctcatcg gctcggtcca ggatttgggc tataaggtcc ttggttttag
    11041 ctgagcaggg tggttatcat gtttggaacc cgattcgggt gcacaaagta atcaatgcga
    11101 gtgggccgtt ttactcgcgc aacggcgcgg cgttttcgcc ccagcggtgc aggcgccgac
    11161 catggctagc tcgcgatcac atagcgacgc gagcagtccc gatggtcggg tcggggaagc
    11221 aacgcgtagg tcattccgag atcctctatt cggtacgggc cgacttcgac ttcaccggtg
    11281 ctggcccgcg cactcgtaac atccatccgg agccctccga ctaccgagca gccgatcgtc
    11341 gagacaggag tgtcatgctc agggtgatgc tgtgcggtgc aagtgacacg gcagacgtcc
    11401 gggaccagtt cgccgaggtc atcagtggac tcggtggcga gcctctgcac tacctagggg
    11461 gcggtattca gtacctgaac gcggccgatt ccagctggtc gcgcaactca cagatcacca
    11521 tcagggccgc tgatttatgc gtgttcgtga tcatcgagag atacggcgaa atcacgtgga
    11581 gcaccgagct gcaggaggca agaacggcag gcaagccatt tctcgtgctc tgcctggacc
    11641 gcacgtacat caaatacgaa gtgctgcgga agagtagcat cgaggggact gatatttacc
    11701 ccgaggacga ccgtcggctg gtggaaaccc tccgtgagtt ggagttcagc tggcagctca
    11761 ccatcgtctc gttcggctac ggcacgttcc aacagatcct gcgtcgccag ctggcgacgc
    11821 ttttccactg gacgctgcga gaacagcagg accgcaaccg ccgtgcatca atcacccgcc
    11881 tggccaccga acgcgttcgg cttaatccgg tgcaactcgc cgacgcggtc cggatcgcaa
    11941 cggacgacct cgaggaaaag aacattcgga agcgagccgt tctcgcattg acaggtactg
    12001 gcgtcgacgc ggacgtcgtg ctggatttgc tttcctcaga tgagcaagga gtgcagcgcc
    12061 tcgcggtcgt ccacttggcc aagctctacc gcgatcgccc tgcggacccg gagtttctcg
    12121 cccagtgtgt gcatgcagcc aatgctgcgg aggatgttgg aatcgcacgc cgactggtcc
    12181 ctgtgctgct agaactcgac ctcgctcacg ggctagcagc actggacctg atgtcggtcg
    12241 ccgaggtagg tatccgccgc cggatcgccg aaagcctcga gaagctggag agggcgatca
    12301 tcgcgaacga gctaagcgcg gaagcggtgg caatgcttgg acgctgcctg caagatgccg
    12361 ccgagaccag ttggaaggcc cgctgccgac ggctccgctc tcggttgtca gcggagtagt
    12421 ttttagtcga agaggaccac gaaggtgaag atgcgatggc ctccttccac cgaatacgtg
    12481 tgctggacga tcgttcccag tcgcccgcgg tgcgtcagag cgtcgtgaag tctgggcgag
    12541 acctgagcaa ggtgctcggc ggtcacgtca acgtacgaaa cgtggccgcc gtccagatcg
    12601 ttccaactgt cgtcggtgcg ccgccattgc tgaggagtca tacccacgtt ccaccggacg
    12661 atgcgctgca tgcatcgtag tcgtgcttag tggggactcc gttacgtcgc cgactgtgat
    12721 ctcttcttgc cgccgtaacc ggacgagcac ggcccggtca cggcggccag catcggtttc
    12781 aacgtcaccc gcgcggcgta tcgaggctgc cgatgatcag ggtaacccca cggactcgac
    12841 ctagttccgg ccgaagccga accgagcatc tgagtccggc tactatcggt agcttgtagg
    12901 taatatttcg tagcaagtac gtggcgaggt gcggcaggca ttcgcaatgt gcgaagtgtg
    12961 atgtcctgac cacttcgtcc gcatgtcggc gtactgttct gacggcgaat ccgggggtgg
    13021 gtgccgcgaa acgcgaatag tcactcttcg tggcctgatg cgtcgttagg gtgaagtggc
    13081 cgcattctgt acctgttctg ccacggattc ggcctatttt gttatatccg gggttgaggg
    13141 cagggggccg tcaacggcaa ctccggtgta tgacccgggg agggctgatg cgtcgtcgtg
    13201 agcatggttt cgccgcggcg ctggcgaaca gggagttccg cgcgctgtgg ctcgtcgagg
    13261 cgctctcggt tttcggtgac cagctggctc gggtcgcgct cgcgttgctt gtgttcggcc
    13321 gtactggctc ggcgagtttg tcggcgctga cctacgcgtt gacgttcgcg cccgaagtcg
    13381 ccagcggctt cctgttatcg gggcttgcgg atcgtttccc acgacgcgcg gtcatggtga
    13441 cgacggattt ggtgcgcgcc ggatgcgtgt tcgccatggt tgtcccgggc ctgccgttgg
    13501 gcgtgttgtg ggggttggtg gccgccctgt cgctggcgag gccgccgttc aaggccgccc
    13561 agcaggcggt gctgccggag gtgctcggag ctgacctgta tccggttggt cttggcttgc
    13621 ggcagatcac gaaccaggcc gtgcaggtcg ccggattcgg tgtcggagga gtgttggtca
    13681 ccgcgatcgg ggccgggccg gtgctgttga tcgacgcggg aacctttgtc gtgagcgctg
    13741 ccgtgcttgg cctggctgtg gcggctcgcc ccgccgcccg acgcggaaaa gcggagcgtg
    13801 cgtcgggccg agcgccgcgg agaccggacc gccggttgct cgcggtcttc atggtgggcg
    13861 cggtgatcgg gttgctgatg gtgcccgagg ggctggcggc gccgtacgcg agcgcggtgg
    13921 gcggagcgtc gttcaccgtc ggtttgctga tggccgccga tccgatcggt ggtgtcctcg
    13981 gcgggtggtg ggccgcgcgg agcacgcggg aggtgacgcc acggtcggtc cttgtgcccg
    14041 cggtgttctc cgggatcccg ctcgcggcgt gcgccgtggt gcccgggtac gtcctgccga
    14101 tgctgctctg ggcgagctcg ggggcgttgt cgacggtgtt cctggtccgg cttcaggtcg
    14161 tgattaccga ggtggttccg gatgagtgcc ggggtggggt gatgggccgg ttcagtacct
    14221 gcgtgaccgt gtcgcagggt gtggcgatcg ccggtgcggg tgtggtggcc gacggcggcg
    14281 cggggccggt gtggacggtc gcgttcgccg gggtgcttgc gtcggtgtgg gtggtcgtgg
    14341 ccgggttcgt gtggtgtggt gctcgtcctc ggcgcgcgcg atgcgccgag gacgagcacc
    14401 cgtcgtccac ggatggctca gacctccttg ttacgcatcg cggcctcctc ccgagacgtc
    14461 cggcggtagg aggggtcaac gactcgcaga gccgcagcgc gagggctgac gccctccgcg
    14521 ggaacggaaa gtgagcacag tatgccgacc tggtcacgag cggtacaggg aggtagggcg
    14581 gctggccgta ctggctggtc cgtttggtcg cactcgaggg cggcacgccc cttcgtcgtg
    14641 ctcgtcgacc tcgccgccct cgcggtgatc gccgcgggac cgttcgaggt ccggcggtgg
    14701 cagcagctcg cgctgtgcgg tggcatcgtg gcgtgcgggc tcgtcgccgc ggagctcgcc
    14761 cgcgaggtcg agcggcgacg ccgctggttc gccggcgtcc cccacatcaa cttctcctcg
    14821 gtgtggacgc tggcgggcgc gctcgtgctg ccgccggcgt tggccgggct cgtcgccgcc
    14881 gcgctctacg gccacctatg gctgcgctgc accgcgcatc tgccagggat gcgcctgtcc
    14941 cggatggtgt tcaacgccag caacgtggtg ctctcctgcc aggtcgcggc gtgggccacc
    15001 gaggcgacgg gcctgtggcc attcgcgctc gaccgtggcg cggcgatgct ggcctgtctg
    15061 ctgctggtgg tgatgctcta ctacgcgacg aactccgcga tcgccgccat cacggtcgcc
    15121 ctggtcagca cggagcggtc cttcgtgctg ttgatggggc cgctgcacga gaacatgctg
    15181 gaactggcca cgctgtgcat aggcgccatc gcgggcctga tcttcgagac cgtgccgccg
    15241 ctgatcgtgt tgttgttcct gcccttgtac gcgctgcaca agtccgccct gatgcgccag
    15301 ctcgagcacg cggccacgat ggacaccaag accgggatgc tcaactcctc gaactggcac
    15361 gcggtcgcga acgcggagct gaaacgagcc aggagggacg gcaccgaact cggcatcctg
    15421 atgatcgacc tcgactactt cagccgcgtg aacgacaccc tcgggcatca ggccggcgat
    15481 gacgccctaa gcgctgtggc gcggcagatc cgcaaaaccg ttccgcgcga tgacctgtgc
    15541 ggcaggttcg gcggggagga gttcgtggtg gtgctgccct gttgcgacgc cgagcgaacg
    15601 cgggagatcg ccgagcgggt gtgccgcgcg gtcgcggacc tggacgtggt cgccaccgcc
    15661 gcgaacacgg ttttctcggt gacggtgtcc atcggtgccg cgacctaccc gggacgcggc
    15721 accgaactct ccgacctgct cttcgccgcg gatctcgccc tgtacgcgtc caaggacgcc
    15781 ggccgcaacc gcgtcagcat gcttgacccc tcgtagcgcg atttcaggct ttgggtgtgc
    15841 tcgaacgcgc tccgcggtac ttctccgccc aggacgccag cgggcgcaac gcgatcagca
    15901 actcctgtcc ggcctcggtc agctggtagt cgacaccgtc gaaggtgcgc ccccgtcctc
    15961 ctttctccgt gcgagccacg aggttgtcct cttccagcct gcgcaacgtg ttggtcagga
    16021 cccggttgct gagcgggcgg tcgtgtgacc tccagccgat ccggtcctct gtcgcgttga
    16081 cactgtccac gatgtccgaa taagcgagct tgccgagcgc gagcgtggac agcacggcga
    16141 ccgtccagtc gcctcgtgtc acccggagcc cttccaggac ggcctgccgg taggggatgt
    16201 cctcgtccgg aacaagatcg gtcacggagt tgtgcctacc acggtgcccg ccgggacgcg
    16261 cggtgacaac gtcactggca tcccaagttg cctcaacccg cgttttcatt agggcaaacg
    16321 agtgaataag gcccttggga gcccaggttc actaggtcct gaacttgaac tcacaaggcc
    16381 ctgctgcgct aaaccggtga ctctcgggcg tccggctcgg gaacggaaac agctgggtgg
    16441 ccgaccgggg tccgagggcg ggcgcgacgc cccttcccgg tcggccatcc ggcagccacc
    16501 agcaccacga cgcgagacag gacgtacgtc gttcggtcgg agcgagcgga acctcgacgg
    16561 ggccgttcac ggccggtcga accaacgggg gagatatgtc gatcgatagt ttcgccgccg
    16621 aagtgcggcg ccggtgccga cggcaggggg tactggtgcg ggagctcgcg gaccgtacga
    16681 ccttcagccg cagccacatt tcgaaggtcc tcaacggcgc cagagcgctg agcggggagc
    16741 tcgcgcggga gatcgacgcc gccctcgacg cgggcggcgc cctggtcgag ctggcgctga
    16801 gcgagatcga tgcgcccgtc gcgccgccgc ggccacggca gctgccccct gtcgccgcga
    16861 ccttcgtggg acgcgagcgg tgcctcgcgg cgttcgatcg tgtcgccgcc gccgcgcggc
    16921 attctgggca ggccgcggtc atcgcgatcg agggcggccc ggcggtcggc aagaccacgc
    16981 tcgcggtgcg gtgggcggcg caggcggcgg atctgttcga ggggtgcctg ttcgcggatc
    17041 tgcgcggcgc cgcaccaggg cagcccgcgt ccccggaagc ggtgctggat cagttcctgc
    17101 gcgccctcgg cgtcgctcca gacgcggcgg ggacgacggt ggaggaacgc gcggcgacct
    17161 accggtccct cgtgatgcag cggcaggtcc tggtcgtcct cgacaacgcg gcgagctatg
    17221 aacaggtcaa gcccctgctg cccgcggcgt cggtggccgt ggtcaccagc cgagcccacc
    17281 tgtccggaat cacgctcgac gcgggcggca ccaccacgat cgtgccaccg ctgacctcgc
    17341 aggaagcggt gagtctgctg cggatgctga tcggacacgc ccgggtcgag gccgaccagg
    17401 gctccgccga actggtcgtc cgccggtgcg gtcgcctccc gctggcggtg cagatcgcgg
    17461 gcgagtatct ccagctgcat ccgaacgaga cgctggcggc gatggccgaa cggctcgcgg
    17521 tcggccgtcg ccgcctggac gtgttgacgt cggcggacga gcagatctcc gttcgccggg
    17581 tactcgacct gagctacttc gccctgccgc cgacggccgc gcggatgttc cgcttgctcg
    17641 ggatctgccc cgcgacgatg gtcagtgttc cggccgccgc cgcgctggcc ggtatcccca
    17701 tcgagcaggc cacccggctg ctcgacgtct tgcggctagg tcacctgctc gacttggacg
    17761 acacaggtcc ggtcccgcgc taccacatgc atcacctcct gcgcacttac gcgggcgagc
    17821 aggcggtggt cgaagaacac ctgtcggacc tcgagcgggc ccgtgaccgg ctgctgcgct
    17881 ggtacgtcgc gacagcgtgt gcggcgagcc gggcgatcac accgagctgg ccgagcgacg
    17941 ggctgcgtgt ccgcgtcgac gacatcaccc cgttgcgctt cgagcaccac gacggctacc
    18001 gcgccgccat cacctggtgc gacgccgaag tgcacaccgc catcgcgctg gcacggcacg
    18061 ccaggacaca gttgttcgtc gacctcgggt ggaagctccc ctgcgccctc ttgccgtatc
    18121 tatacatggc gaagtcgtgg tcggcctggc tctccgcggc cgacgacgcc atcaccgtcg
    18181 ccgagacgat cgattccgac accgggcgct cctacgcgct gctggcgctg ggctggatcc
    18241 accacgaact cggccacccc gaggaagccc tcgtccacct ccgccgggca cacgacaccc
    18301 agccccggga cggcgatccc ggcgtgctgg tgtggatcgc gttcgcgctc gccgccgtgc
    18361 acacctccgc cggccgccac cgcgacgcac gcgactgcta ccacgacgcg atcaactccg
    18421 tcaccgccag cggaaccccc gacagcggcg ggcacgatca cgcgctcgcc gtactgcagg
    18481 ccatgctcgc caccacgcgc gacattctcg gcgaccactc cggtgccgac cgtgccctca
    18541 ccgacgcctt cacccgcgcg cggcgcctgg gttacccgtc cgtgctcggc ctgctgcacc
    18601 accgacgtgg cctgctccag atggaacgcg gccagcacca tcacgcactc gacgacttcg
    18661 aagacgccct ccgccaccgc cgcgcgatcg gcgcccggtg ggccgtcgcc gaaacgctgc
    18721 tggcgtacgg gagcgcgctc gccgaactcg gcagccagga acgcgcggcc ctcgccctcg
    18781 ccgacgccac cagcatcctc gacgagctca acgctccccg cacccgcggc cctcgcatcg
    18841 cgctgaccgc cgcgtcggcc aacaccgcgt aaaaccgaga cacgacaagg agaaacaccg
    18901 cacacaccac cgcaaccacc ttcgagcatc gtcggcgaga cgatttcctc ggggttgtcg
    18961 catgtccaaa ataacgcgtg ccaatatgag cacaaaaaga gcacaaaaag agccctaaac
    19021 tgtgctcgcg aaatctcttt accgcgacgt ttctctctga gactgttagt ggtgtcgctg
    19081 ccgaacaacc tcaactcatt cggcgcagac gtcagttacc gattccagtt ttcgggagtt
    19141 tcctcgtgaa gatgacatcc atcgccgccc gatccgccgt ggtcctcgcc gccgccacag
    19201 cctcgaccct gcccgccgtc atggcgcacg cgacccccgc tcgtccaccg ctgaccccgg
    19261 tcgcccccgg gagtgccagc gcggtggcat cgcaggtcaa caaagacatc atcgccagcg
    19321 gtcaggagtc cggcgtggtc gacgcccgtg tcgcgggcgg ctgggaccga tgcccggcag
    19381 ggttcatctg cctgttcgac ttctgcgacg gccaaggcaa gatggcctac ttcaaatggc
    19441 gctctcccga tctccgtgcc caaggaatga acgacatgac ctcggccgtg tggaaccggg
    19501 ctgacgccga cttcgacctg tacgagggct acaactacac cgggctgcat tcccggttcg
    19561 accgaggcat gcgcgtcaac ctgtcgtggt ggggtggcga caatttcgac agctcgctga
    19621 gacgacgcta acgacccttc agtgatttct cgcgcctgtc aggccatttc ctcccttcac
    19681 ttcagcggcc cgctctcggt ccctccccct caccgagacc agggcgctga acacccccgg
    19741 ggtggtcacc accgcagacg gtggccaccc cggggacccc gacagaaacg gattcgccat
    19801 ggagcagctc atcctcggcg ccgccgcgga cctcgccgcg gaacatcgcg atcggcgcat
    19861 caccctcgac gaagtcgccg cggtcaccgg cctcaagaaa caccacctcg ccccctatcg
    19921 cagcgctctg gccacccttg ccgaaccagc cttctccccg tcgcgtacgc ggccgacctc
    19981 gcgagaggtg ggatgaactg atgcgctgcc acgacgtaca ccttctcggt ttcggcgccg
    20041 ccctcggtga actcgtcccc atcacaagcc tgcgcacccg cacccgccgc cacagcgcgg
    20101 ccgcagcggg acagcgcgcg gtgtcggtgg cgcgcggcca gtccgggcca caactagccg
    20161 tgcgggccgc ccgccacgca ctcgacacct cgaccctgct caccggcagc cccgcggcac
    20221 ccccggacat gctgttgcac tcctcgatct ggcgcggagg gaaaggcgtt gatttctgga
    20281 acgccgccac ctacgtcagc caccaactcg acctcggcgc gggcagaggg ctcaacgccg
    20341 agctgaacct gatgtcgaac tcgatgatcg gcggactcga actcgccgcg agcatcctcg
    20401 ccggacgccc cgaccacgac acaatcctgc tgaccagcgg cgacaccttc ggcgcgcccg
    20461 cgttccccca tctgggcacc gacatcggca cctcctacgg cgacggcggc gccgccgtca
    20521 tcctcggccg ccgcccgggc gcgttcgccc aactgctcgc gatcgcctcc tacagcgacc
    20581 cgaccctcga agccctgcac cgcggcgaca ccggattcag cccacccggc agcgtcgagc
    20641 tcgccgcgat cgacctcgtc gctcgcaaac gcgcctacct ggccacaacc accaccgaat
    20701 cggtacaccg ccgcaacgcc gtcggagtca tcgaatccgt caaagcggcg acgggcgaag
    20761 ccggggtgcc cctcgacagg atctcctggg cggtactgcc gcactacggc aaagacctcc
    20821 tggccagcca atgcctgcaa cctttaggca tcccggccga ccgcacgttg tgcaccgtcg
    20881 gcgatcagtg ggggcacatg ggcgcagcgg accaaatcgc tgccctgacc catctgttca
    20941 cccgccgcgt cgtccggtcg ggcgagcacg tgctcgtgct cggggtcgga gtcgggatga
    21001 cctggaccgc ggccgtcctg cgcatcgaca acaccgacac cgaccccgcc gcactcgccc
    21061 gattcgcccc acccctgctg tggtcaccgc aactacggca gaaggcaggg tgaagcgccc
    21121 gcgacgcaag ccttcgatgg gcaccaaaga gacctccatt aagaggtcac agtggacaga
    21181 cacctagcgg aaaccgttgc cgcacagaac tttcacgcta catacaccga tgaatgaatt
    21241 cgaatcacat gtatctcgat tggagtcacc atgatcttcc tgccgaagca cgcgtcccgt
    21301 aagcgtggtg cggtcacggc cttgacgctg accgccgtcg ctgccgccac cgcgctcgcc
    21361 accacacccg cctcagcggc atcctctccc aacgccggag atctgcctcc cgcggcggcc
    21421 tcggcccacc acgaccgccc agcggggcaa gaacaggcac gcctcaacgg acccgactac
    21481 tgggtcgagg gcaacagtgt gcggttgcgg gcgagaccga tcgacggccc cgtactgaac
    21541 gtcctgcacc agggcaacgg actggacccg ctctgctggt ggaactggga cggagatcct
    21601 tggcttcggg cccacgcctg gggcggggcc acgggctacg tccactggcg actggtccac
    21661 atcggagcgg cccgccctgg ccgctgctga ccggatctcg gttctatccc gtgcggacgt
    21721 tgccagtggg gcggcgtcca cgcccagacc ctggtgcggc ggcctgaccg gaaacttccc
    21781 acctcggcgc cgatccccat cccggtgccc aggccgccgc accagtccat accccgctca
    21841 cggcaaccat cagacaggag cacggcgatg gctgactaca ccctcggctg cgggcatgcc
    21901 cagccgtttg aggacatcga cgagacctac ctcgacgact ccgcggtcga ttccgtcctt
    21961 gccccgagcc acttgtggtg ccgccactgc cagaggtggt ctcccgttac cgcgttcacc
    22021 accgacaccc ccggcacggc ttccgacgac acaggtaccc acgccgagga agcgtcgacc
    22081 acggtgccga tcggcacttg tgtacacaaa ggacagacgc gatgaggatc gtttcagccg
    22141 ccgatggcga ccatggcgag tgcgccgccg agcaggcacg gaccgaacgg caccgccagc
    22201 cgatcctcgt cgtcgccccg gtgcgcgccg ggaaccacga tcagcaccat cgccagcagc
    22261 gaggccacca gcagcgcgcc gaggacctga ggccaaccgg accagccggt caccaggccg
    22321 accaccgcag ccaggcccac gtctccggcg cccaggcccc cgttcgacac cacggccagg
    22381 accagaaaga acatccccgc cgcacccagc gcggccagag ctcgcagtcc ggacgcggac
    22441 tccccgcgcg cgatagccag caccacaaac ccggctacgg caccggccag ctgcggccag
    22501 accagcgcac ggggcagccg atgctcgcac caatcgatca ccgccaacgg cacacccacg
    22561 atcacgacga ccgtgtagat ggccagttcg ccacgggcac cgacacgcca ggccaggatc
    22621 gccagcaccg tcgcggtgag cacgccgccc aaccaccacg acccggccac ctgccgccga
    22681 ccgtggggaa ggaaccggcg ggtgagcacg ctcgcgctca cgccgagcac catgccgacc
    22741 gcggcggcac cggcgatcca ccagctcgtg gggtgctgca ctttccctcc ggccgtcgcg
    22801 tgaccttcgc gtacgccatc gtgcccgccc gacgcgaggg cctgccaacg ctcagcccaa
    22861 cgagtgaact tcccacccag tcagcgctcc gccacggcgc caccgcgaca gtcggtcccg
    22921 gggcaggctc gccgctgcgg cttgacgtca aggggctcgc cgcccgcgcc gtccagcaac
    22981 catcgacgaa ctcgggaacc gtgatgaccc ttcaccgcag cacccgcctc gccctggtcg
    23041 tcctcgccgc cagcggcctc accgtgtgcg cctgcagcgc ggacgacgac accaccccgg
    23101 tgccgcctac gtcccccgct ccgcccgcgg tcgcgagcac gacgcgcgcg gtggcggcgg
    23161 attcggccaa gcaggcggct atcgccgcgt acctcggtat gtggaacgac atggccgatg
    23221 ccgcggtgac gtcggactgg cagtctccga aactcgctgg caacgccacc ggtgaggcgc
    23281 tggagaccat ctcccgaagc ctctacgccg atcactacaa cggcctgatc acccgggggc
    23341 ggcccgcgaa ctatcccgcg gtggcgacgg tgcagcccgg agacaagccg gtatcggtca
    23401 ccctcaccga ttgcggagac tccacgaact ggttgaaata tcgggccgac aacggccaac
    23461 ccgccaacga cggccccggc ggacgccgac acatcgacgc ggtggtgaag aaggcggtcg
    23521 acggttcgtg gaaagtcacg actttcgcgg tacatgaggt cggatcatgc gcagggtaag
    23581 ccaaatatcc ttcgcaacct tcatggtcgc cggtctcgcg ctcgggatga ccgggccggc
    23641 gctggccgac ggttggggca acgtccgctg tggtgacggc gggaatccat cctgcgatct
    23701 cggtgccgga cggggcgggg acaccgctcc ccatccggca cctgctcccc atcccggggc
    23761 cccgaaagcc cgtggcggtg gcccggcagc accgcctgcc gcgcctggtg accggattgt
    23821 gggtggtgac ggcacccgcg cggattgttc ctacgcgcgc agcgactacc aacccccgac
    23881 gaatggaatg cgaaccgttc gccacgaccg agaaccgcgg gagaccggcg cgactcgatg
    23941 ggtgtcgctg acccggcagt atcccgtcgg cgcggtgctc gcgcagagcc cggggcaggg
    24001 cggtggttgg tatgtctatc aatgcggtgg cgggacgcga gacgcgctgt atcggtctcc
    24061 ggtatggatt cctgatggcc agacgccggg cgccgcgccc tcgccggagc agttggcgca
    24121 gcaggcgcgt tcgcagttgc ggttgccgac tccggtgatc gcgtcgagcc cggccggaat
    24181 gcagctggtg cggttgccga cgtggctgtg gctggaccgg gcgatgtggg cggcgcggtc
    24241 ggcgacggcg tcggtgcccg gggtgtcggt gaccgcgact gcgaccccga cttcggtgtc
    24301 gtgggtgatg ggcgatggcg gcacgacgag ctgcgccgga ccgggaaccc cgttccccga
    24361 gcatggtgga gatccgcagg cggcgtcgcc ggattgcgga tacaccttcc gccggtcctc
    24421 ggccgccaca ccaggcgagc ggttcaccgc gtcggcgacc gtgcactggc ggatcgcctg
    24481 ggctggtgcg ggcgcggcgg gaacgtttcc tgacatgacc actagcgcct cctcggcgtt
    24541 ccgggtcgcc gaggcccaag cattgggaac cggatagccg tacggccttc tcgattggtc
    24601 accgaaaaac acacattgtc cttgcctgat cgcgtattcg cggcgaatcg cttttcgccg
    24661 ggtggattcg cggtaggggc gaactatgcc tggaggtcga catcgtgacc agtaccgaca
    24721 ctcccgcccg gggaccggac gcggatcgtt ccgcgtcgtg gctggattcc acaggagccc
    24781 cggcgaggac acgaggacac cgttcccgcc gcctgccgca tctgctgatc ggcgtgctgc
    24841 tcgtcgtggt ctgcgtcggc gccgcggtgt ggtggaccgc cagcgcgggg gaccggatgc
    24901 cggtcctggt cctcgcgcga ccggtcactg tcgggcaggc gctggttgcc gcggatctgc
    24961 gccgtggcga tgtcgccgtg tcgaccggca tcgcgacggt gcccgccgac gccgcgtcgg
    25021 cggtgctggg ccgcccgatg gccaccagcc tcgctcccgg cgcgctgctg accccggaca
    25081 gcgtcagcgc cgccttctca ccaccagcgg ggcgggcggt ggtggggatc ggggtgaaac
    25141 cgggccaatt cccgaccggg ctcgccgccg ggaacgcggt gaccgtcgtg gccgcgcgcg
    25201 ccgcctcgtc cgcggagtcc ggttcgccga actcggcggg agcgggaaca gcgtggccag
    25261 ccaccgtcac cagcgtcgct cccgcggaga ccgatcagct gacggtggta tcgctggagg
    25321 tcgaagccgc cgccgcgatc gggctggcgc aacagccctc ggggcagctc gcggtggtgc
    25381 tgcggcccgc gggtggtgag cgctgatgct gatcgcgttg accagcctca aatcctcccc
    25441 gggagtgagc acgctcgcgg tgacgctggc ccagcggtgg ccgcaggccg atctcacgcg
    25501 ccggatcgtc gccgagtgcg acccggccgg cggtgatctc gcgatgcggt tcgggctcga
    25561 cccggcaccg ggcttggtca gcctcgccgc cgccgcgcgc cgcgccagcg gccccgcggt
    25621 ggtgtgggag cacacccagc tcctgccgag cggcgctcgc gcgatcgtcg ctcctcccgg
    25681 cggcgcgcac gcccgcgccg ccctgcacac cctgatcacc gcgccggacg gaccgctgct
    25741 ggacgcgacc gcggccgagc ccggcgtggt cgtgctggcc gattgcggac gcgcggaccc
    25801 gggctcgccc gccgaagcga tcgcccgcca ggccgacgcg ctcctgctgg tctccggcgc
    25861 gcgcggcgag gacctcgccc acgtcgcgac ccggctgagc gagctcgccc gctggacacc
    25921 gcgcccggga ctgctgctgt ccgggcaggg ctatccgaca ccggagatcg aacgcgaact
    25981 cggggtgccg gtgatgggcc gcatcccgca cgatccccgt gccgcgaccc atcacggcga
    26041 cacccccggc agcgccgaga gcggcctccc gcgcttcgcc gcggcactgg cccgcatcct
    26101 ggccgcaccg ccaccaccga catcgacacc ccggtcgggt ctgccgccgt cgatacctgg
    26161 ggtcccggac cggcgcctgc gcgaccccgg caggccgctc acgggcccgc cccacacgcc
    26221 accgacgcca tccccaccgc cgggcacacc cgcaccatgt ccgccgccat ggaacgccta
    26281 cggcgatcag ccccggcagc ccggtgacac cggccgggag gtcacaccat gacacccccc
    26341 gaagccgacg acgtctccgg cagggcgcag gcccggctgc gggcggtgtt gcgggaggcc
    26401 ctcacccgcg acctgtcgca ccggatcgac gacgccaccg cgcaggcggg cccgtcggtg
    26461 agcgcgtccc agcggcggga cgtagcccgc gcggtcctgg ataccgcgcg caccgcgcac
    26521 accgaggccg aactcctcgc cgggcgcgcg ctgctggaca ccgccacgga gcagcaggtg
    26581 accgagcagg tcctggacga ggtattcggc ctcggcggac tgcaaccgct gctggccgac
    26641 ccggcggtgg agacgatcac ggtcaatcgc tacgaccggg tgttcgccca gtacaccgac
    26701 ggccgccgag cccaggtcgc cccggtcgct gcctcgaacg acgagctcac ggacctgatc
    26761 cggacgctgg cggcgcgcgc gtcgtcggag gagcgccggt tcgaccgcgg aagtcccgcg
    26821 ctgaacctcc agctccccgg cggggaacgc ttgttcgcgg tgctcggcct gaccgcgggc
    26881 ggggtgacgg cgtgcacgat ccgccggcac ggctacctca ccgccaccct cgcccagctg
    26941 cgccgccgcg gcacgctcga tgccggactg gagcggttcc tgcgcgcgct ggtccgggcg
    27001 cggcgcaacg tgctgatcac cggtggcacc ggggccggga aaaccacgct gttgcgcgcg
    27061 ctcgcggcgg agatggaccc gatggagcgc ctggtcacga tcgaagacgc cttcgaactc
    27121 gggttggagc gcgatcccgc gctgcatgcc gatgtcaccg cgctgcaggc ccgggaaccc
    27181 aacatcgagg gggaaggggc ggtggatcag gccgagcttg tccgctgggg cctgcgcatg
    27241 tcaccggacc gcgtgatcgt cggggagatc cgcggcgccg aggtcatccc gatgtgcaac
    27301 gcgatgtcac agggcaacga cggctccatg gccaccctgc acgcctccag ctcgaagatc
    27361 gcgttcaccc ggctcgcctc ctacgccgca caaggcccag aacggctgcc actggaggcc
    27421 accgccctgc tggtcgcgag cgcggtgcat ttcgtggtgc acctcgaccg tgccgccgac
    27481 cgcgggaccc gggtgatcgc ctcgatccgc gaggtggtcg acgccgagga cggtgcggtg
    27541 atctccaacg aggtctaccg ccgcggcgcg gaccgccgcg cggtgccggt ggccggggcg
    27601 ttgcgcacgg acaccctcga cgacctggtc gcggccgggt tcgacccgga cctgctggcc
    27661 cgtcgggagg ggtggtgggc gccatgagca tcgacaccac cgctccgctc gccgccgtgc
    27721 tcggtgtggg gaccgcgctc ggcgtgctcg tgatcgtggc cgcctggcgc cggcccgcgg
    27781 cggcggtgtc gccgccgccc gcgcggcgcg ccgggctggt tcgcaccgcc cgcggccaga
    27841 cggtcgaccg acgcgcgctg gcgcgcgtcg tcgtggcgct cggcgtgggc gcgctgaccg
    27901 gggccctcac cggctgggtg gtcggtgcgg tgctggccgc cgcgacggtg tggttcctgc
    27961 cccgcctggt cggcccggat cacgcccacc agcggcgggt cgcgcggatc gaggcgatcg
    28021 cgtcgtggac ggagatgctg cgcgatgtcc tgtccgcggc ggcggggctc gagcaagcca
    28081 tcctcgccac cgtcagcctc gcgcccgcgg ccatccgcgg cgaggtcgcc gtcctcgcgg
    28141 cgaggctgga aagcgggcag cgcctggcgc cggcgctgcg cgccctggcg cgcgagctgg
    28201 acgacccgac cgcggacctc gtcctcgccg ccctcgtcct cgccgccgag caccaggcgc
    28261 gtcagctcag cgacctgctc ggctccctgg ccagcaccgc tcgcgggcag gccgcgatgc
    28321 ggatgcgtgt ggagaccggt cgggcccgga cgcggacctc agtgcgggtc atcgtcgtca
    28381 ccacggcgat attcgccgcc ggggtggtgg tgttcaaccg cgcctacctc gacgtctaca
    28441 acaccgccac cggccagatc gtcctgctgc tgctcggtgg cctgttcgcc gccgggttcg
    28501 cctggctcgc ccggatcgcc accagcgcag gacaggcgcg ggtgctcgcg ctcaatgcgc
    28561 cgggcgggat cggagcgcct aacggtggcg aaatagtggt cgggggaggt gagcgcgcat
    28621 gatccccgcg ctgctgttcg gcgccggggc tggtgccggt ctctggctgc tgctgacctg
    28681 ggccctgcca ccgtccccgg cattgagtga ccggctcgcc caggtcagcg cgcgaccacc
    28741 ggccacaccg atcatcgcgg cggcggaggc cacctgggtc tgccgctggg ggcgggtgtt
    28801 cgtccccggg ctgcgaaagc tcgggctgcc cggcacgaag atcgaggctg atctgcgggt
    28861 catcggccgc ggggtcgata cccacctggc gtccaaggca ttgctcgcgg tggcggggct
    28921 gctgaccccg tggctgctgc aaaccctgct cgtcctggtc gggctgccgc tcggcgtcga
    28981 agcgccgctg ctggccggac tcgtgtgcgc cgcactcggc ttcgtgattc cggatctcgg
    29041 tgtccgcacc aaggccaccc gactgcggcg cgagttccgc gacgctctgt cggcgttcct
    29101 ggacctggtg tggatcaccc tcgctggggg tgccggtgtc gaggccgcgc tcggcgacgc
    29161 cgcggctgtc ggagcggggc cggcgttcga caagatccgc cgcgccctgc acacggccca
    29221 gttgactcgc accaccccgt ggaacacatt gcgccggctc ggcgaggaac tcgacatcac
    29281 cgaactcgcc gaactcgccg cctcggtttc cctggccggc accgaaggcg cccgcgtccg
    29341 cgcttctctc gccgcgaaag ctcagggtct gcggacccat caggtcaccg atgctgagtc
    29401 cgacgcccag gccgcgaccg aacgcatggc cttgcccgtc acggtgttgt tcctcggctt
    29461 cctgggattc atcacctatc ccgcagtgac ccaagtcctc aatggactct agctccgctc
    29521 ggcgtacctc ctcggcacca aggaaggcat tgcaccacaa gggaaagaag acaccgtcat
    29581 gttgcactac atccgtatcg tctgggagct gacacgcacc cgaatcgcgc tgttgcgcgc
    29641 cgccccggag cgtggggaga tcaccaccac cgtcatcgtc atcgccgtgc tggccatcgc
    29701 cgcgatcacc ctccttgcgt tcatcgtggc gaaattgacg cggaaggtga actcgatcaa
    29761 cctcggcctc ggcggctgac gatgccgacc aaggccgtcc gcaccagtag cactcgcgtc
    29821 cgcgcgttgg tcgagcgtgt ccggcgcgcg ctgcgcgggg accagggcga ggccaccgtc
    29881 gaactggtca tcgcgacccc gctgctactt ctcgcgttgc tggcgatcat ccagttcgca
    29941 ctgtggtcgc acgccaccca cgtcgcccag gccgccgcat cccaagccct ggccgccgcc
    30001 cgaacccagg acggcaccac tagctccgga cacgccgccg ggcagcgctt gctcgacgag
    30061 cttgccgccg gcccgttgcg cgacccgagc ctcgcggtgt cccgcggtgc ggccgcggtg
    30121 tcggtgagtg tccgtggcga ggccgccata gtcctgcccg gcgtgcacct gcccgtgcac
    30181 gccgaagcct ccggggagat cgaacgcttc gtgcccgata ccgcgccctg acttctctcg
    30241 ccgcagcggc gattccggcg accggctgaa aggaacctct gatgtcacac cataacccgc
    30301 ctgtcacggc gatgccggtg cgcgcggcga cgttcccgga cgggccggat tcggtactgc
    30361 tgaacccaga cattccacgg gcgcggtggc gtggcgaacg tgtccacgcg ggactgcgtc
    30421 accggtttgt cctcaccgga ctggctggtg ccgccctggc gccactcacg gcggtgtcct
    30481 gcagcgggtt cgccgcggtc ttcttcctgg gcgccggaat cctcgcgctc gggatgagcc
    30541 tgctcgccgg ctggtgtagc gccgctggca tgctcaccga ccaccgccat cccgcggaca
    30601 gtccgtgtcg gctggatcgt gtgcggggcg agtttttctt tcgcagccgc gatttcaccg
    30661 acctcggcac cgccagctac gccgtgcgga ccctgatcgc cggggtggac gaactgcacc
    30721 gcagcccggc ccgggcgtgg atcgacccgg ccgtgccgcg ggaggtgcat cgggtggtgt
    30781 ggcaggcgtt gtgctgcctg gaccgcaccc gcgccgcccg gagcctggcc gacgaactcg
    30841 ccgccgatcc cgattccgcg gttggcgaac tggctgccgc ggcccgcgag gcggtcaccg
    30901 tgatcgacga cgccctggac gacgtcgtcc ggcacgtgca cggctgcctg gtgctgaccc
    30961 gggcatggga ggcgaaactg cggcacagcg agctgaccac ccgcaccgac cacaccctcg
    31021 ccgcgctgcc cggcgacacc gaggtccagc agctggcgca ggccgcggaa gcgttgccgc
    31081 agaacgtgtt cgcctacgtc accgccgccc gcgacatcac cggcacggga gcgttcccgt
    31141 gggaacaacc gacctcggcg tggtcacgac ttctccgcaa cctgccccgc gggcgcagcc
    31201 gaggcaggcc atctagaagg gcacaagcac ggcgagcccg gtccggagag gagctgtcgt
    31261 gaccgggcgc gcgccgaagg agcccacggt ctgggtgcgg cggtggtggg ctgccgagcg
    31321 cggctcggtg accgccgagg ccgtgctggt gaccccgctg ctggtgatgc tgctgctgtt
    31381 cgtggccgtg gttgtgcatc gcggcgtcga cgcccggttg cggctcgacg acgccgcgca
    31441 ccaggccgcc cgcgccgcca ccctgcaccg cagcaccacc accgccacca gcgccgctcg
    31501 cgacaccgcc cgcgccgcgc tcgcgcgggc cgggctggtg tgccgggacg tcaccaccac
    31561 gatgtccggc accctggtgc ccgccggggc ggtgaccgtg cgggtgcggt gcaccgtcga
    31621 cttcggccag gcactgctgc tcggcgtccc cggcgggaag accttggacg cgaccgccag
    31681 cgaagtggtc gacgcctacc ggtcctcaca tcagggcgcg ggtgcctgat ggtcggctca
    31741 gcgcgcgagc cagtgccccg ggacgcaggc acggagctgg gcaccggtca ccgtccggtg
    31801 ctcgagcaac ccggtggcga cacggccgat ctcggtccag taccggtcga tcagatcctg
    31861 cgcgatgccc gcccacaggt cgggctggcg ggtggggagg ccgtaggcgc ggcgggcttc
    31921 ggcgatcacg gccaggtcgt cgtggccgcc gtgaaggtaa gcgtcaagcc ggacatcctc
    31981 ggccgtgatg tcctcgcggc gccgctcgac cgtgctcgtg gtgtcgagga catgccgagc
    32041 ctgggcgagc ggtccggcgt gcgcgacgac cgccagcgcg gacggatcga cccggcgggg
    32101 ccggaccgcg gtgaacccgg cccgaccggc ggtgcgaggc cgcagcgtga cgtagcgcag
    32161 cgagcggccc tgcagcaggt agacgaccgc gtgtccggcc tcgtgccagg cggtcagcga
    32221 atcctcgtag gccacgggcg agtcctgcgt ctgcggcgcg gtcacggcac ccattctgct
    32281 cacaacgtcg gctcggcgcg caccagcggt gccagcgctg caccggggcc tcggctgcgg
    32341 tggtggcggg ccgagcgcgg ctcggtgacc gccttcgtgc tcgccctgct gatcgggctg
    32401 ctcgccctga ccgggctgag cctggacggc ggcctcgccc tggcgagcaa ggtccgcgca
    32461 ggcgggcacg ccgaatccgc cgcccgcgcc ggcgcccaag ccctcgacct cgccgcgtat
    32521 cgcgccagcg gtgttgttcg gctcgatcca gggcgggcgc gggacctggc gcagcggtac
    32581 ctggccagcg tcggcgccac cggcaccgtg gctttggccg gcgacaccgt gaccgtcgac
    32641 gtcaccgcca cctaccgcac ccagctgctc tcgctgatcg ggatcgagtc catccacacc
    32701 cacgggcgcg gcgccgccca cccgcagcgc ggggtcagcg gcatcgagcc ctgaccaccg
    32761 gccgcaccgt cacggaagga gaacatcggc atggtcacct cggaagacga aatcacccgc
    32821 cgcctgcaag aacgagactc cgcccgcagc gcgcgccgtg agaaggcggc caccaccgtg
    32881 ggcgagctcg cccgccggca cgccgagctc gccgggcagc tcgccgacct cgaacgcgag
    32941 ctcggcgagg tcctgaccgc ggccggcgag gacatcgacg tgcccgagct ggcccaggtc
    33001 accgacgtcc ccgccgccga tctcacccac tggcgagacc aggccgccaa gcccgcccgc
    33061 ggcggcaagc gctcacgccc cagtgcgaag aagaacacca cccccggcaa gggcacccag
    33121 gccgccgccg agccgcgcgc cgcacacccc gcggcaccgg caccggccgc acctgaatcc
    33181 gtcggcgtcg gcggggtagc ggtcggcgct gcgagcacct gatggctccg gctcgccgga
    33241 cgggaatcgc gcgcgtcgtg tcgctgctgg gccgggcggt gcgcgggcta ctcgctgcga
    33301 tcctgctagt cacgctggtg gccggtcttc ccgtagcgct gatctacggc gtcggatggc
    33361 ccctgcccga tcacctgccg aacatggacg agatcggctc cgcgctcctc tcgccgatgt
    33421 cgacaagtct cctgctcgac acgctcgcct gtctggcctg gctgatctgg ctcgtgttcg
    33481 tcatcgaggt cgcctcgtgc gctttcgacg tggcccgggg tgcctggcgg ccggaactac
    33541 ggttacagag cggaccggtg cgtcgcgtcg cggccgtcct cgtcagcgcc ctactggtcg
    33601 ccctactggg ccgcaccgcc gcccccgctg agggcgcccg gcccgtcggc cacgccccgg
    33661 tcgtcgtaac cgccctcgcc cggcccccag ccgtctccgg cgaacacccc ggcaccccgc
    33721 cgccccagtc cacggccgag cccgggaccg aacgggtccg gctaccggca ggcggggtgc
    33781 acgactcgct gtggaggatc gcgcaacgct gcctgggcga cggcgaccgc tggccggaga
    33841 tctgggccct caacgacggc agcccccagc ccggtggacg cgtgctgagc actccgaacc
    33901 tgatccaccc cggcgacacc ctccgcctcc ccgtcaccag cccaccaccg gccgtctcgc
    33961 ccgccgcggc accaccggct ccagggccga cgagcccggc tcccgccgaa ccagcgcacc
    34021 cgccgctgcc cacgaccaca ccacctccct cgacgcccgc cccggccacc acggatcccg
    34081 ccgccggccc cgcggcggat cgccccgccg gaggcgcggt gacctggggc agcggcgagg
    34141 tgttcgtcag cgtgggcctg gcggcggcgg tcagtgcgct gctggtgctc gcgcggcggc
    34201 gacggcaggc gcggtaccgg cccggcagcg gccggcgcga cgacgacctc ccggtcgcgc
    34261 ccgtggtgta ccagctgcgc ttggcccacc tgcgcaccca gcaccacgac gaagacaccg
    34321 acctggaggc agagaccctc aaggccgaga ccgacgaggc gggcgacccc gagaccgacg
    34381 actcagccag gcacgaggac cgccacgacc ccgcgcgcgt cggcgcggca tcccggtcga
    34441 ggcgcgcgga cagcggtccc gagcgccggg tgcgggtgca cgcaccccgc gttcgccggg
    34501 tagtcggcgc ggctgcaccc accggcgcgg gaccggcgca gccgccgtcg gtggtggaca
    34561 tggcaatcga cacaacgggg cgtcgcgctg gcggcgggaa cgccgacgct acgggggagg
    34621 gcgcgcaggt cgcgttcgac ctggctcgcg cgcacggcct cggtgtggtc gggccgggcg
    34681 gctacgccgc ggcgcgcgcc ctgctgctca ccatgctcac caccgtgtcc gagggcgggc
    34741 cggcgccgag ggtggtcgtg cccgccgctg atctggcccg gctgctcggc gtgccggtgc
    34801 ccgctacggg cgtgccggag gcggtcaccg tcgtggccga cctggacacc gcactggccg
    34861 ccctcgacgc cccgcaaccg ccccggcccg ccgtcctgat cgcggcgccg ccccacgaaa
    34921 ccggccagca ggcgcggttg cagcagctgc tcgacaacaa cgcccagtac ggcctgaccg
    34981 cgctgctgct gggccaatgg cggcccgggg tgaccgccta cgtcaccgcg gccgggatca
    35041 tctccgcgac cgaccccggc ctcggcgaac ccctacgcgg cacccgtgcc ttcaccctgc
    35101 ccgagaccgc cactcgcgac ctgctggcgt tcctgcgcgc cgcgcggccc cgcgacgtcg
    35161 ccgagccgca cgctcccgcg cctgaccaga cgtcgatgcc ctcggaggag gtcactcctt
    35221 ccccaccaga gcgcagtgga gacgggtcga accacctgga gatcacagcg ggcccggtta
    35281 caccggaacc ggattccgcc gaggccgacg gcgaacccgg cggcggacca ctcccgcgca
    35341 cgccacggac agccgatacg gccgcgggga cgcccgcgcc actggtgctg acggtgttcg
    35401 gtgctccggc tctgcactgg cggcccgacc ccgcccgacc cgaggacacc cgcgacctgt
    35461 ccggggaatt cagcagccgc ccggtcgaac tgctggtgta tctcgcggtc catcccggcg
    35521 gggcatcccg ggacgggatc gtcgacgccc tgtggcccga cgagccgccg cgtaacccgg
    35581 ccagcgtgct gcgcaccgtg ctctcccgga tccgccgcgc cctcgacacc gccacccgtg
    35641 gcgccgtcgg cgagctggtg atggccgagc atggccagta ccggctcgac cccgcggtgg
    35701 tggaggtgga ctactcggac ttcgccgccg cggtcaccgc ccgtcgcacc gccaccaccc
    35761 ctgaacgccg gaccgacgcc tacgaaatga tcgtcgcgca ctacggcggc ttcttggccg
    35821 agggcctgga ggccgagtgg ctcgtcgccg cccgggaagc cacccgccgc gacgccctcg
    35881 acgccgtcgc cgcgctcgcc cgcgcccggg tcaccgacga cccggactac accctcgatc
    35941 tgctggaggc cgcgcgcgcc ttcgatccgc acaacgaact gctctaccgc gacatcatgc
    36001 gcctgcagca cgtgctcggc cggcacgagg ccatctcccg caccctggac ctcctgcgca
    36061 ccagactgtc cgaaatagac acacgtccca ccgcggacac cgtcgatctc gcccagcggc
    36121 tgcgcgcccg cgacaccggg atctcggtcg acgagttctc cgtctcccga tccacggcgc
    36181 catgaatgag cgcacccgcg gttctcgaca gcacctcgcc ggaacggaaa ccgaggcacg
    36241 ttccgcgtgc gatcgaggca attgcgcgga acagcgaaat acctcgattt catgtcccga
    36301 tcccgttcac gccgatgcta gcgtcgaccg tgatagcacc accgtcgagg ccgaagaaaa
    36361 agaaccccgt ggacgtgtct ctttattcca cgacaacacc ggaactgttg ttcgtcgaac
    36421 gtcgcgcgcg actgccgcgt accgcgaaca cggcacaaaa ccactttcgc ggccacgatg
    36481 cccagtgcga caccagcacc tcggacgccg agcaccacgt ccccgcccgg ctacccggcg
    36541 ccacacccgc ggatcgaagc gacgcggaga gtgatcgcca cccggggggc cgccgacccg
    36601 gcctctccgc ctcgtactcc ggtatccgac taaggcggat ccccccgtat cagccgttct
    36661 cgcagctcac accccctgca aggggatcca ccggtgtccc agactcgctt gacaccaagc
    36721 gggtaagcac atcaggcccg gcggtgtcac gcaccttcgt cgtcgttccc ccagtgctca
    36781 ccaccgcact tcactcacct cattcacctc tcattcctct ttttgttttc ttaaaaagaa
    36841 cttctttcat tcgcggtcct gtctgtttcc gccgtatctg tttcgggtcg gacgaaaatg
    36901 ctctgacctg cgcaaacgct gacgggaatt gcgtgccgct cgcgtcgcaa gtcggccaaa
    36961 atttcccgaa attgatcccg gaaacctatt gcgtggcgcc cggggtcgag ttacgtttgt
    37021 tgtgtcaccg ggaaaaccgg aaaccgccac cgaaaccgca agggctgcga atcatgcccg
    37081 accggaaaat cgtgaaatgg ggctagttat ggactacatc aagccgttca ccaccaccga
    37141 aaacggtgaa accgtaatgt gctaccccgt tactttcgac ggccggaaaa tcaccgtaac
    37201 cggccccgac ggcccccgca cccgcacccg acgcgcccgg actggctacg ccaccgccgc
    37261 gacgttgcgc gccatgggct acaacgatct tcgcgccgtg tgccccgatg gcaccgccga
    37321 cgttttcggg ttcaccaccc gcgccaattg acgccaccgc cgccaaccaa attcggcggc
    37381 acccctccaa aacatccgcg caaccccaaa cgaaagggcc acgccgtgaa ccacaacgcc
    37441 aacgacccgc gcccggtgta cgtgatcgac ccggacgccg accccgggcc agtgccggaa
    37501 gtcgtggtgc gttcggacat cgaaaacggg tgcactgtca cgggtgtggt gatcgacccc
    37561 gccgacgcgc aacaagtgtt gtacggcacg gtaacccgac cggacggcac attcgccgga
    37621 agctactacc ccgccgacac cctacgcggt gaccactggc gagtcgtgac cgccgacggg
    37681 aagcactacc acgccaccag cgaataccac gcggttgacg cactggtcaa cgggttcacc
    37741 gccagctaaa accacccaac ggcaagggaa accaccgcca tgacgcacac ggacaccaca
    37801 cacgccaacg agaacgacca accggaaacc ggaattgtgg aatgcggcgg ttgttcccgc
    37861 ccgctggaag tcacgcgcca gcaatgggaa tcgtgggcgt ccctgccgtg cccgtgcggt
    37921 tccgccgccg acctcaactt cgcccgccgt cactgcgaat ggggcgaatc gctgatgtag
    37981 cggggacacc gtgcccgtac ccggccccta ccccgccgac cgaaccacgc gaaaggaacc
    38041 gcgccatgac cacgccagcc acgactccgg ccacgggcag cacgcccgcc gccccgggcg
    38101 cggcacccca ccgactgcgc aacggcgaac tccgccgcat ggtggccgaa caactcgccc
    38161 acgaccccgc cgccgcactc acccccggtg ccatcgcaac caaactcggg cggtcatccg
    38221 gcgcggtcgg caacgcggtg gcgaccctgg aatcgcgcgg ggaagccgaa aagatcggca
    38281 ccaacccggt cacctatcgc gcgaccgcga aaaccgccga cgccgccaaa acgccaacgg
    38341 tcgccccgcg cgggaccacc gccacccccg caccgccgaa acccgccccg ccacccgccc
    38401 cggccccgtt ggtgaccgat cccgtacgtc gcccgaacgg gcagatgtac cacccgcgca
    38461 agctgtccgc gctctccgac gtcaccgcgc tacggcggtt gcgggaagcg aacgtgtccg
    38521 cgctcatgta cggcccgccc ggtaccggga aaacgtcggt ggtggaggcc gcgttcgacg
    38581 acctgatcac gattcagggc gacagcgaca ccgtgaccga tgacttcgtg gggtcctaca
    38641 cccaaacccc ggacggtcgc tacgagttcg cctacggccc gctggtgacc gcgatgcgtg
    38701 acgggcgggc gttgttcatc gacgacgcca ccctcatccc gccgaccgtg ctcgcggtgg
    38761 tgtaccccgc gatggacgga cgccgccaaa tcatcatcaa aacccacaaa aacgaggtgg
    38821 tggacgccgc gcccgggttc tacgtcgtgg ccggacacaa ccccggggtt cacggtgcgg
    38881 tgctcaccga cgcgttgtcg tcgcggtttt ccgtgcaggt tcacgtgtcc accgactacg
    38941 acctcgccac ccagctcaag atcgacgccc gggcggtgcg cgtggcgcgc aacttggccc
    39001 agcggcaggg gaaaggtgag atcgggtggg cgccgcaatt gcgggagctg atcgcgttca
    39061 accgcatcgc cgacgtactc ggcatcgacg ccgccgccgg aaacctggtc ggcatcgcac
    39121 ccgaggaaga ccgcgccgtg gtcgccgaag ccgtgcgcaa cgtgttcggc gcgaacctcg
    39181 ccccgttgtc tctcgggccg cagttctagc cacgcgaacc accacccgcg cgactgtccg
    39241 gaaaggacac cgaccatgag cacccacgta gccacaccca ccgccacacc caccgccgtg
    39301 tttcccgccg cccccgcgtg gctgaccctg tccgccgcat tcggtgacga ggtccccgcg
    39361 atcgctgatc gcgacgacct cgtgatcact gtcgcccccg gggcggggca cggtgccccc
    39421 gcgtgtttct tccccgactt cgccacgatc gaagtcgatg ggtcccatat ggataaagga
    39481 gtcgaccccg ccaccgtcga accacaccgg gtcggggacc gcaagcggta ccgcaccgca
    39541 tggggactac tgacccacga atgcggccac gccaaacatt cggtgtggcg cgtgcccgac
    39601 gacgcgcccc cgggcgcggt cgcggcggcg gacctactgg aagagacccg catggaagcc
    39661 gcgcaagtgc gccgccgccc gggcgaccgg tactggctgc gcgccagtgc cgccaacctc
    39721 atcctcgccg acaccaaagc caacgacccc gtcgccgcac cgcaaatgac cccgcaagac
    39781 gctgcccgca gtgccgcgct gctgctggcg cgcgtggacg agggcatcct caaccgccgc
    39841 gaggtcatcc gcgtcgagcg cgtcgtgcgc gacgttctcg gcaccgacac cctcgcgaaa
    39901 ctccgcacaa tctggcgcgc cgcgcaccgc accgccgacg acaacgccac acgcatgatc
    39961 gaactcggac gcaaatggtg cgaaaccatc ggcaccgacc ccaaccaacc ggccgacacc
    40021 cccgacccca acgccaccaa caacgcgaac ggaaacggga acggggcacc gtcgccgctg
    40081 gcgagcgcga tcaccagcgc cgccgccgcg atcggtatcg gggtcgccac cgaacccgcc
    40141 cccaccgacc ccgtcacgca agcgatggac gcccgcgccg ccgacgacaa cgcacgccag
    40201 caggcgcaac gcgacgcgaa cagggtcttc ggcggcgtcg gtaccggacg tgaccgcacc
    40261 gcccgtcata tccagggcac tcgcatgccg agtacaaccg aacgcaccgc ggcgcggcag
    40321 ctcgcccgtg ccttgaccac cgccgggaac cgtgaccgca cggccaccaa aacgcgctcg
    40381 acggtgcccc cggggcggtt gcggatgcgg ggcgcgatga ccgccgacgc ccaacgggcg
    40441 gcgggcgcga tgcccaccgc cgaaccgttc acgcgcacta cgcgcgccac cgtgcccgcc
    40501 ccgccgctgc ggctcggcat catctgcgac gtcactgcct cgatggccgc gttcaccgcc
    40561 ccggtggcct cggcggcatg gatcctcgct cacgccgccc ggcacaccgc cgtacccgcc
    40621 gacaccgcca ccgtgacctt cggcgcgggc atcgttaccc cgatcacacg tcccggtgtc
    40681 accccgtcga aggtgaccga attcggtacc cgtcagggtg ggcacgtcat cgacaccgcg
    40741 atcaacgccc tcgacggtgc cctcgatttg tcccgcccga ccgccgcgcg cctgctggtc
    40801 atcatctccg acggaatgtt cgaggccaca acccggaatc ccgggcagaa gatgctcgac
    40861 cggttgcgcg ccagcggatg cgcggtgttg tggctagcgc ccaacacatc ggcaatcgac
    40921 ccgatgaacg gcgccaccgt gcacaccctg accaacccca ccaccaccgc ccgcgccatt
    40981 gggcaggccg ccaccgccgc cttgcgcgcc acccactgaa ccatcccacc gcccgggggc
    41041 ggagtaaccg cgcccccgag tgacaaaacc cacgaccgcg acggaaagag agaccgacca
    41101 tgatcaccac aca
//
