LOCUS       NZ_CP059997            20684 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3664269
            Orig. end                         :: 3684953
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20684
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="18"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20684
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20684
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10684](-)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10684)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            259..678
                     /locus_tag="HUW46_RS17105"
                     /old_locus_tag="HUW46_03385"
     CDS             259..678
                     /NRPS_PKS="Domain: Polyketide_cyc2 (15-129). E-value:
                     1.2e-07. Score: 24.2. Matches aSDomain:
                     nrpspksdomains_HUW46_RS17105_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009071905.1"
                     /locus_tag="HUW46_RS17105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03385"
                     /product="SRPBCC domain-containing protein"
                     /protein_id="WP_215548218.1"
                     /transl_table=11
                     /translation="MTVGRSKDAGWMIGVSETVASPVATVWDFMLSQDGLATWLGGDVT
                     LQPEKGAPYETADGTTGEVRGFREHDRVRLTWRPKDRAHESTIQFTVSAKGNKGDKTTL
                     RFHQERLTGPEEREAQRVHWRGVLDTIVHKLGNRD"
     aSDomain        304..645
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS17105_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.20E-07"
                     /label="HUW46_RS17105_Polyketide_cyc2.1"
                     /locus_tag="HUW46_RS17105"
                     /protein_end="129"
                     /protein_start="15"
                     /score="24.2"
                     /tool="antismash"
                     /translation="SETVASPVATVWDFMLSQDGLATWLGGDVTLQPEKGAPYETADGT
                     TGEVRGFREHDRVRLTWRPKDRAHESTIQFTVSAKGNKGDKTTLRFHQERLTGPEEREA
                     QRVHWRGVLD"
     gene            714..1247
                     /locus_tag="HUW46_RS17110"
                     /old_locus_tag="HUW46_03386"
     CDS             714..1247
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667091.1"
                     /locus_tag="HUW46_RS17110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03386"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_215548219.1"
                     /transl_table=11
                     /translation="MTDTALLVVDVQNLFVAITGDEGLAAVTAINDHVAKAVANEWPVY
                     YLRDYQPDADTDGDDTLLHPALDVRGTVVEKGPGHRGALSGFLRLPAEMKGRELGAGGL
                     SALAGHLARDGVRALVVTGIATGICVSATAVDAVRLGYEVTVPLSACAPAHAYPGHDDA
                     VVEALREAGVTVVA"
     tRNA            1313..1402
                     /anticodon=(pos:3665616..3665618,aa:Ser,seq:gga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS17115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_03387"
                     /product="tRNA-Ser"
     gene            1313..1402
                     /locus_tag="HUW46_RS17115"
                     /old_locus_tag="HUW46_03387"
     misc_feature    1346..1360
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.54"
                     /tool="antismash"
     misc_feature    1362..1377
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.19"
                     /tool="antismash"
     gene            1620..1880
                     /locus_tag="HUW46_RS17120"
                     /old_locus_tag="HUW46_03388"
     CDS             1620..1880
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787937.1"
                     /locus_tag="HUW46_RS17120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03388"
                     /product="hypothetical protein"
                     /protein_id="WP_215548220.1"
                     /transl_table=11
                     /translation="MAGVEEIRAGIALANEKASASIAALQQAAQALEEAQQSLAQATQG
                     STQDEVAQAHGMLAEALQGITGTQSTIQACMSSADAYSARL"
     gene            1883..2131
                     /locus_tag="HUW46_RS17125"
                     /old_locus_tag="HUW46_03389"
     CDS             1883..2131
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020668718.1"
                     /locus_tag="HUW46_RS17125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03389"
                     /product="hypothetical protein"
                     /protein_id="WP_254126251.1"
                     /transl_table=11
                     /translation="MSALEEFHSLLAMSRAKVEDAGAHTRRALELLGEARAAIVDGHEQ
                     AEPWLPPQLDGALEKIGNDAALMSTADDLLKEYEARL"
     misc_feature    1915..1925
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            2131..4863
                     /locus_tag="HUW46_RS17130"
                     /old_locus_tag="HUW46_03390"
     CDS             2131..4863
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020668719.1"
                     /locus_tag="HUW46_RS17130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03390"
                     /product="FtsK/SpoIIIE domain-containing protein"
                     /protein_id="WP_215548221.1"
                     /transl_table=11
                     /translation="MGFSKSNEQRARVVSALDAMRQQIGLVLGAARAGREVAETELAGL
                     ELEQKVVQTGLDAAAQDEEILAALRRPAMSQVSSWLNTVRAQFYTDASTVPRRLRELVA
                     DASGGAGHLPPGEWLGQVGVGSSPPELWRVGSAVLSTSDPRDRFDVAVPLLDESHLAIT
                     SAPKTREQVDALVEALLMRVLSSVEPGAVRVHLWDIGQLTSVLPNLYPLSKTSALTLYD
                     PTRLQDLLDDLSGHIRRIHAHAMQAGHTSLRGMRATVGKRTEPWRIAVLFGNGETWATE
                     PVRDLKRIAGGAHAAGISLIAVDVPHVLGGSVENIRLLDEHRAVTSMTGPNLVTQLDPP
                     IPSGQVSGAAGKIAEALIAKQGGPRSFTDLLPTELGKANSAEELRAPVGFFEGDPVEVV
                     IGDSSPHALIGGPSGSGKTNFLYALLGSLAARYPPDELALYLLDFKEGVSFAGLAPGRK
                     DATWLPHAKLIGVNVNTDREFGLALLRFLSDELRRRSTAAKEHEVTNLAGLRQEDPDGH
                     WPRIVAVVDEFQYLFAGRDAVTNQATALLEDIARRGRAQGIHLILASQDVAGIEAFWGK
                     PAVFEQCTLRIAMPKARRVLAEANTAAVSAPRWHAVLNHESGVAHGNQLAHVPDASGKD
                     VFAALQRRLWDAYADEHDRPRLFDGAHSPVLEHVPAFGELKPGGAVTALLGQSIDVEDT
                     ACGIELAHAPGRNLAVLGTAAAEALSIMDSAARSLARQYEQGAVEFLLRCPVERCLPAV
                     ERLAEDLVAHGHRAVVLDALAPTLAELATTEPETAKILLLYGVDAELPVLEAKEPGQLK
                     SGLDHLRMVLKQGPGKGTHTLGWWRGTARLKDTLGFGGNDDIGAWAALDVQGSELTPFA
                     AGQVVHWSPRPGRALYFDRSTHATPEVIIPFLRPDRENP"
     gene            4860..5231
                     /locus_tag="HUW46_RS17135"
                     /old_locus_tag="HUW46_03391"
     CDS             4860..5231
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020668720.1"
                     /locus_tag="HUW46_RS17135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03391"
                     /product="hypothetical protein"
                     /protein_id="WP_254126253.1"
                     /transl_table=11
                     /translation="MSSDGVTAAMRYKDIVASLSRADEDLRAWEQNRAIELEGAIADAA
                     ASVEAAREREERATQRAQHWWRMAADNVSRLPWLELDEPPGPDPTARYDWLSRYVDGVK
                     PLYNDLVQAVLQLGWRARR"
     gene            complement(5303..6487)
                     /locus_tag="HUW46_RS17140"
                     /old_locus_tag="HUW46_03392"
     CDS             complement(5303..6487)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016337737.1"
                     /locus_tag="HUW46_RS17140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03392"
                     /product="MFS transporter"
                     /protein_id="WP_215548222.1"
                     /transl_table=11
                     /translation="MNLAAPPGRATKLPLPALLALATSVFLGCLTEVVPAGILLPASAD
                     LGVSPSATGQLVTVYAITTALTSVPLTAMTAGLPRKKLLLALVAGFVVTNLVVAVSPWF
                     ALVLLARIVSGAITGVLWSLVANYAMRLVPADRSGRALAVAMAGTPVGFALGVPAGAAL
                     GDLVGWRWVFVVMALIALPLLWWVAAVVPPLAGEARGTRASPRTVLRTPGLRPLLALVI
                     TFSLAHNLFYTYLGPVYARAGHAGLLSTGLLLFGLATVAGLWLVGVVLDRHPRAVLLCC
                     AATAACCFAVIAVGSHSVGVLLAASAVWGLAFGGAPTSFQAITAMLAGRTADTAQSLTV
                     ASWNGAVAGGALAGGLVLGGAPVALPWVAVVLMVVPLLLAGSVATSVRRARRVE"
     gene            complement(6601..7776)
                     /locus_tag="HUW46_RS17145"
                     /old_locus_tag="HUW46_03393"
     CDS             complement(6601..7776)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.4"
                     /locus_tag="HUW46_RS17145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03393"
                     /product="S8 family peptidase"
                     /protein_id="WP_215548223.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.2e-23, bitscore:
                     82.9, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRKPRAAVLAVCFAAAVGVLPAAAVTAAPASATSAATAVYIVRL
                     KPMAAEKDKVTAAANAMIGKYGGTLRRVYYSVSQAFSVDLTEEQHTKYLSDEAVSTVGA
                     NQVYTAAATQENPPSWGQDRIDQPALPLDHRFTYPNTAANVHVYVLDTGVRTSHQDFGG
                     RAHAAFDAVDPAGNQSGTDCNGHGTRVAATIAGKNFGIAKEASVESVRTLGCDGKGTSE
                     QILTALDWVNVNAKRPALLNLSFAGPGGTVVDIQLYKMTQLGLAYTTAAGNGGADACDS
                     TPARQTTGITVGATDATDRRVASSNFGGCVDLYAPGKDIKTADSRSDTACTTVSGTSIA
                     SAEAAGVAAMYLSAHPDTTSDALAEALAGAATKDKISDPGAGSNNLLLHTA"
     gene            complement(7855..8304)
                     /locus_tag="HUW46_RS17150"
                     /old_locus_tag="HUW46_03394"
     CDS             complement(7855..8304)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012314.4"
                     /locus_tag="HUW46_RS17150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03394"
                     /product="thioredoxin family protein"
                     /protein_id="WP_215548224.1"
                     /transl_table=11
                     /translation="MGSRMRVLAAAVAMTAGLVGGAAVTPAAATTLAPQDDTIVDVTSA
                     NYDQVMEMSKTKPVVLDFYATWCGPCKNMEPYLEKYHTADKGKWIWAKVDLSDHKTNQD
                     IASKYNVEYIPTLIDIASGKEKGSRVVGFDTGSGPNDLRTWLNGL"
     misc_feature    complement(8288..8306)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            complement(8316..8711)
                     /locus_tag="HUW46_RS48350"
     CDS             complement(8316..8711)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226697.1"
                     /locus_tag="HUW46_RS48350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="rhodanese-like domain-containing protein"
                     /protein_id="WP_254126619.1"
                     /transl_table=11
                     /translation="MLPLIGREELKREMDEGTVIVVDTMPVTYYEREHLPGARNIPGFP
                     YEQAAEFTDAHAPSVLPDPSAAVVVYCANTPCRNSEFVGARLLELGYTDVRKYREGIED
                     WVAAGYATESGPQTTAQPAPVSGNRTE"
     gene            complement(<8820..10004)
                     /locus_tag="HUW46_RS17155"
                     /old_locus_tag="HUW46_03395"
                     /pseudo=""
     CDS             complement(<8820..10004)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014218.4"
                     /locus_tag="HUW46_RS17155"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03395"
                     /product="cytosine permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTDRHDDYSLTPVPAAERRSWPSVAVQRFGQVSSFQQFIVGAILG
                     YGMTFWNAVLAITIGSVLLEVITVLLGIAGVREGLSTSVLARWAGFGRKGSALVGLLVA
                     ISLAGWFGVQNGIFAHGMHALGGAVPEWAWAVLGGVVITAITVYGFRIMAWTAYLTVPA
                     FLLLAGYSIVDALGSHSLPALVSGPPPGPPLSLGAGTTLVAGAFILGALMTPDMTRFNR
                     TPGDVVKQTLISVTLGEYLIGLIGVLLAHATASSDIVGIITSSSGVLGTLVLATAILKI
                     NDWNLYSSSLGLVNVVDVLFGRKVARVHVVLVLGVLGTAASAFGIADDFAGFLTAVGVL
                     TPPVAGVLIAEYFVVRRCRPVFDALREHGSAPGAHRDWMPSALVSWALGTAFAVF"
     gene            complement(10001..10684)
                     /locus_tag="HUW46_RS17160"
                     /old_locus_tag="HUW46_03396"
     CDS             complement(10001..10684)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082649.1"
                     /locus_tag="HUW46_RS17160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03396"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_215548226.1"
                     /sec_met_domain="CDPS (E-value: 1.1e-59, bitscore: 200.9,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEASPLSSGCARLFPDVPHACVGVSPFNGYFTAERLIRLAAWTA
                     ENFAEFHFFVPDDVTAYTLEAMGYPPARAKQKAHRQACHVHNKITAALTAIGIADPASR
                     VLGMARLRDMLAYRRLANEVEERFESDRVFRAACYGASSWVLQGKTDTGSNPARLRLAV
                     QYFLAELPLFAASGTITGNTGSMFVYHQRVPFLQRFFDREFSFRPHAGQGFLVVREPVL
                     EAANR"
     gene            10888..11844
                     /locus_tag="HUW46_RS17165"
                     /old_locus_tag="HUW46_03397"
     CDS             10888..11844
                     /GO_function="GO:0001216 - DNA-binding transcription
                     activator activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="HUW46_RS17165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03397"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_215548227.1"
                     /transl_table=11
                     /translation="MELELKHLHHLRVVAKAGSLNRAAAQLVLPQPALSRELRRIEQLL
                     GDELFERDRTGVRPTAFGQLILDYADGILAHTAKIGSDLAHQCAHRTKALRVGWSATAL
                     SGLLLDALDVTGYGDQAEIRTAESTAEMLEWFGRGELDLAVLSEQCEVPLPANTGRVDL
                     SDDPLLIMLPDWHPLASRQSVQLAELEHERWISSTGPDRCREFLKRVCRPFGFSPQIAH
                     HVSVSGPRDEIVRYQGDVTLVQTLRPLAPGVVHRPISDLLMRTSHFLLYREDSPIAARI
                     DVLAGLITDAYWEGRRGERVPSRTFPAGLPRLATRTS"
     gene            11854..12774
                     /locus_tag="HUW46_RS17170"
                     /old_locus_tag="HUW46_03398"
     CDS             11854..12774
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="HUW46_RS17170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03398"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_215548228.1"
                     /transl_table=11
                     /translation="MDIELRQLRILTAVAEAGGLAGAAVALGMSQAKLEQQVQRLERMV
                     GAALLHDGPAGITFTEAGEVLLEHASVVLPQFDRMLAAARAGAEAPAPNVVRIGAVATP
                     VLPGLVRAIDEAVPGAELSVRIEEPGTDLAEALLRDELDLAVVRQHPATGGALPPSLAC
                     SPVATEPLFVGIPPGHALGTPVSIAPAALSGHRCVLLDQSVQPLTLAVLVAFADAGADP
                     RFCYAASEWAALCLGSGTGILTVTAPPTTPMPGTAYRPVRCAAAMSALVLAWVPGGPVT
                     DCAARIHEAAMETHADCLRALATGP"
     misc_feature    complement(12805..12820)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.53"
                     /tool="antismash"
     gene            12942..13181
                     /locus_tag="HUW46_RS17175"
                     /old_locus_tag="HUW46_03399"
     CDS             12942..13181
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS17175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_03399"
                     /product="hypothetical protein"
                     /protein_id="WP_215548229.1"
                     /transl_table=11
                     /translation="MALSRKIGALGVLTAATAAIALSTVGTASASWVAGTYHSPADCQS
                     AGNWLAQQGRAHYFHCDYGIVAGQGPEWTLVVEW"
     gene            complement(13254..13736)
                     /locus_tag="HUW46_RS17180"
                     /old_locus_tag="HUW46_03400"
     CDS             complement(13254..13736)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS17180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_03400"
                     /product="hypothetical protein"
                     /protein_id="WP_215548230.1"
                     /transl_table=11
                     /translation="MFGRAVPSPELVAAGAAVGLIHVERVPLWAAHWLAGGLGDSDALV
                     VLAALDGTDGDEVRAVLPQALASCGVTPPDTVAEAADVLFTHFARLFADGLVDEREVAE
                     RVGEIALKTSYDDGLVRLPLGRTSLFADEWGEHWGQDETVLAAEIRRACAAQLEPH"
     gene            complement(13740..16163)
                     /locus_tag="HUW46_RS17185"
                     /old_locus_tag="HUW46_03401"
     CDS             complement(13740..16163)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642147.1"
                     /locus_tag="HUW46_RS17185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03401"
                     /product="endonuclease/exonuclease/phosphatase family
                     protein"
                     /protein_id="WP_215549928.1"
                     /transl_table=11
                     /translation="MVLTVTSLAVPAAATPSTGAVLAEVYGGGGNSGATLTNDFVELAT
                     RGTGAADLTGWSVQYLPAAPGPTSKWQVTPLTGAVRPGGRYLVAEAKGNSGTTALPAAD
                     ATGGINLSGTAGTVALVATTQPLTCRTAADCAADANVRDLVGYGDAAVREGTAAAATTN
                     TTSVARGARLADTDDNAADFAVGAPTPTNAKGETPGGDPGQPGTPAKIHDIQGVTRLSP
                     FKDKQVSDVTGVVTALRTFGSARGFWMTDPVPDADPRTSEGLFVFTGSTTPDLAVGDAV
                     TASGTVREFYPDAPATSKYQSLTELTSAKWTVGSSGNPLPAPTVLAPDTVPAQLAPQAG
                     GNIEPLTLEPSKYALDFWEAHESEIVSVSDARIVGRSTEYGELYVTTKPEQRPTPRGGT
                     LYGGYDQQNTGVLKVESIIPFSQRPFPKANTGDVLTGRTSGPLEFDSFGGYTLFASELG
                     QVKDNGLQREVTRKQRSGELAVATYNVENLSAVDDQAKFDQLAHGVVDNLANPDIVSLE
                     EIQDNNGADGNGDGVVAADETLNRFTAAIAAAGGPHYEWREIDPEDKKDGGEPGGNIRV
                     GFLFNPARVSFVDRPGGDATTPVAVNTVHGKPQLSISPGRVEPGNAAWTASRKPLAGEF
                     VFGGRTVFVVANHFNSKGGDQPTQGRYQPPTRSSEVQRVQQAQLVHDFVGKLLAADRGA
                     NVVVAGDLNDYPFSKTVQTLTAGGGLKALIDTLPPQERYSYVFEGNSQVLDHILSSPAP
                     RGIDYDVVHINAEFADQASDHDPQLVRFRPSAGNRVLDAFYDLADWLDRVFPRR"
     misc_feature    16198..16211
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            16392..17654
                     /locus_tag="HUW46_RS17190"
                     /old_locus_tag="HUW46_03402"
     CDS             16392..17654
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018681610.1"
                     /locus_tag="HUW46_RS17190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03402"
                     /product="MFS transporter"
                     /protein_id="WP_254126255.1"
                     /transl_table=11
                     /translation="MTSALVPPAGPSRVLAVAQLTNSVGDGAYYVTSALYFTRVIGLSP
                     AQVGLGLTISWAVGFLAATPLGHLADRHGPRATAILLALATSAFVGSFLFARSFPAFVL
                     VACLYASSQCGLTAARQALLAGLVTAAERTRIRAYLQSATNAGLAVGAALGGIALRVDT
                     PAAYLTVFGMDAVAFLASAAVLRRAPHVPPAPAVTGREPKLAVLRDAPYAVVSFLNMLM
                     LLHIPLIGLAIPLWIVERTQAPTWLVSAMLVLNTLSVVAFQVRIARRVTGTATASRSVR
                     RAGLVLLASCAVFAVSAAGGSPWVAAAVLLVAAGLQTLGEMMQNAGGWEIGFALAPAGK
                     QGQYQGFFGSGFAVARMLGPLLLTTLVLSWGPLGWLLLGGVFAAAGVAMGPATRWAERT
                     RQDADTDSPQRTRLVGSSVDG"
     gene            complement(17655..18581)
                     /locus_tag="HUW46_RS17195"
                     /old_locus_tag="HUW46_03403"
     CDS             complement(17655..18581)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (42-299). E-value: 3.2e-65. Score:
                     212.5. Matches aSDomain:
                     nrpspksdomains_HUW46_RS17195_TauD.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020633010.1"
                     /locus_tag="HUW46_RS17195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_03403"
                     /product="TauD/TfdA family dioxygenase"
                     /protein_id="WP_215548232.1"
                     /sec_met_domain="TauD (E-value: 5.1e-63, bitscore: 212.5,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVDVSAPALREATVPEGGILEGPRVLRRLPGAEPRPYDLFDLRP
                     LGAVIGAEIHGFDLGTELTPELRAELNRALLEWKVLFFRDQRITPAQQRAFAAHWGPLE
                     TNPFIPAGDTDEVTRFTRGASMPGYENIWHTDVTWRPNPALGSVLRLVEVPPVGGDTMW
                     ADMAAAYDNLPPEVRERIDGRTAVHDYLPGFDRFADPALLAAWQDDYPPVEHPVVRTHP
                     ETGRRTLFVNQAFTTHIVGLPRDESDRLLRFLFQQAHVPEYQVRFKWAENSVAFWDNRA
                     TQHYAVNDYHPHPRVAERVAIEGDRPF"
     aSDomain        complement(17685..18455)
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS17195_TauD.1"
                     /evalue="3.20E-65"
                     /label="HUW46_RS17195_TauD.1"
                     /locus_tag="HUW46_RS17195"
                     /protein_end="299"
                     /protein_start="42"
                     /score="212.5"
                     /tool="antismash"
                     /translation="LRPLGAVIGAEIHGFDLGTELTPELRAELNRALLEWKVLFFRDQR
                     ITPAQQRAFAAHWGPLETNPFIPAGDTDEVTRFTRGASMPGYENIWHTDVTWRPNPALG
                     SVLRLVEVPPVGGDTMWADMAAAYDNLPPEVRERIDGRTAVHDYLPGFDRFADPALLAA
                     WQDDYPPVEHPVVRTHPETGRRTLFVNQAFTTHIVGLPRDESDRLLRFLFQQAHVPEYQ
                     VRFKWAENSVAFWDNRATQHYAVNDYHPHPRVAER"
     misc_feature    complement(18751..18764)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            18916..19146
                     /locus_tag="HUW46_RS17200"
                     /old_locus_tag="HUW46_03404"
     CDS             18916..19146
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS17200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_03404"
                     /product="hypothetical protein"
                     /protein_id="WP_215548233.1"
                     /transl_table=11
                     /translation="MADSALGATEALAKARKAASKLKRKDAAVYWATVAQTAVLTEIRD
                     ELRALNQHSGGVTLPDDAPAKRRTSVAVQEP"
     misc_feature    complement(20114..20127)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.32"
                     /tool="antismash"
ORIGIN
        1 tcgacctcgt cgagcggcgc ggtggcggcc aaccgcgaac cgaggagcca gtcggcgaga
       61 tcgccgggcc gatgcaggat ttcgaagcga tcacacggct cgggtccgcc ggtgaggagc
      121 agttcgaggc agaggcaccc cggatcgaat tcgtaactct gcccgtcccc gccggtgagc
      181 agccttgtac ccgattccat gtaaccacta tagtcggtgt cagacacctc tttaagtagt
      241 taccgcgagg atggcgaaat gaccgtaggc agatccaagg acgccgggtg gatgatcggc
      301 gtctccgaga ccgtcgcgtc gccggtcgcc accgtgtggg acttcatgct gagccaagac
      361 ggtctcgcga cctggctcgg cggcgatgtc accctccagc cggaaaaggg cgccccgtac
      421 gaaacggcgg acggaacgac cggcgaagtg cgcggcttcc gcgagcacga ccgggtccgg
      481 ctgacatggc gcccgaagga ccgggcacac gagtcgacta ttcagttcac cgtgtccgcc
      541 aagggcaaca agggcgacaa gaccaccctc cgcttccacc aggagcggct caccgggccg
      601 gaagaacgcg aggcgcagcg agtccactgg cgcggcgttc tcgacacgat cgtgcacaaa
      661 ctgggaaacc gggactagac ctcgacatta ctcgaagtca taccgtcgca agcatgaccg
      721 acaccgcttt gctcgtcgtc gacgtgcaga acctgttcgt cgccatcacc ggagacgagg
      781 ggctcgcggc cgtgaccgcg atcaacgacc acgtcgcgaa ggccgtcgcg aacgagtggc
      841 cggtctacta cctccgcgac taccagccgg acgccgacac ggacggcgat gacaccctgc
      901 tccacccggc gctggacgtc cgcggcaccg tcgtggaaaa gggaccgggt caccgcggcg
      961 ccttgtcggg ttttctccgt ctgcccgcgg agatgaaggg acgggaactg ggcgcgggcg
     1021 gtttgagcgc actggcgggg cacctcgccc gcgacggcgt tcgcgcactg gtggtcaccg
     1081 ggatcgccac cggcatctgc gtgtcggcga ccgcggtgga cgcggtccgg ctggggtacg
     1141 aggtgaccgt gccgctgtcc gcctgcgcac ccgcccacgc gtatcccggc cacgacgacg
     1201 cggtcgtcga agcgctgcgc gaagcgggtg tgaccgtggt cgcctgacct ggcgtccccg
     1261 cagctcagac cccatatccg caggtagagc gcgatcctgt acgctctcct gcggaggatt
     1321 ggccgagcgg cctaaggcgc acgattggaa atcgtgttgg gtgtaaaagc cctcacgggt
     1381 tcgaatcccg tatcctccgc catcgaatac cgctgagcgc cgggtccttc gcgacaagac
     1441 cgcgaaggac ccggcgttcg gctttttccg gccccccatg agggtgttgc cgtaccctgg
     1501 agtggctgac cccccgtcac tgatcaggtg tcggtggcct cacgctaggt tgtgcgcaat
     1561 cggccgtccg cacggccgga tccgcatcag aacaacggca accgaggagt tccgccccca
     1621 tggccggagt ggaagaaatc cgtgctggaa tcgcgctggc gaacgaaaag gcgtccgcga
     1681 gcatcgccgc gctgcagcag gccgcgcagg cgctggaaga agcgcagcag tcgctcgcgc
     1741 aggccaccca gggcagcacc caggacgagg tagcgcaggc gcatggaatg ctcgccgagg
     1801 cgctgcaagg catcaccggc acccagagca cgatccaggc ctgcatgtcg tcggcggacg
     1861 cctactccgc gcgtctctga tcgtgtccgc gctcgaagag ttccattccc tgctggccat
     1921 gtcacgcgcg aaggtcgagg acgccggcgc gcacacaagg cgcgcgctcg agttgctcgg
     1981 cgaagcgcgc gcggcgatcg tcgacgggca tgaacaggcc gagccgtggc taccaccgca
     2041 gctggacggg gcactcgaga agatcgggaa cgacgcggca ctgatgtcca ccgccgacga
     2101 cctgttgaag gagtacgagg cacgcctctg atggggttct ccaagagcaa cgagcaacgc
     2161 gcgcgcgtgg tcagcgcgct cgatgcgatg cgccagcaaa tcgggctcgt gctcggcgcg
     2221 gcgcgcgccg gccgcgaagt ggccgagacg gagctcgccg gtttggaact cgaacagaag
     2281 gtcgtccaga ccggtctcga cgcggccgcg caggacgagg agatcctcgc ggcacttcgc
     2341 cgcccggcga tgtcacaggt cagctcgtgg ctcaacacgg tgcgcgcgca gttctacacc
     2401 gacgcctcga ccgtgccgcg acggttgcgc gagctggtcg cggacgcctc gggaggcgcc
     2461 gggcatctgc caccaggcga gtggctcggg caggtcggcg tcggctcgtc gccgccggag
     2521 ctgtggcgcg tcggttccgc cgttctgtcc acttcggacc cccgcgatcg cttcgacgtc
     2581 gcggtgccgt tgctcgacga gtcccatctc gcgatcacct cggcgcccaa gacgcgggag
     2641 caggtggacg cgctcgtcga ggcgctgctg atgcgcgtgc tcagttcggt cgagcccggt
     2701 gccgtgcgcg tgcacctgtg ggacatcggt cagctgacgt ccgtgctgcc gaacctgtac
     2761 ccgctcagca agacgagcgc gctcacgctg tacgacccga cccgcctcca ggacctgctc
     2821 gacgacctgt ccgggcacat ccggcgcatc cacgcgcacg cgatgcaggc ggggcacacg
     2881 tcgctgcgcg ggatgcgcgc cacggtggga aagcgcaccg agccgtggcg gatcgcggtg
     2941 ctgttcggca acggcgagac gtgggcgacg gaaccggtgc gcgatctgaa gcgcatcgcg
     3001 ggcggtgcgc acgcggctgg gatttcgctg atagcggtgg acgtgccgca cgtgctcggc
     3061 ggttcggtgg agaacatccg cctgctcgac gagcaccgcg cggtcaccag catgaccggc
     3121 ccgaacctgg tcacccagct cgacccgccg atcccgtccg ggcaggtgtc gggcgcggcg
     3181 ggcaagatcg cggaggcgct gatcgcgaag cagggcggtc cgcgctcgtt cacggacctg
     3241 ctgccaaccg agctcggtaa ggcgaattcc gccgaggaac tgcgcgcgcc ggtcgggttc
     3301 ttcgaggggg atccggtcga ggtcgtcatc ggcgactcca gcccgcacgc gctgatcggc
     3361 gggccgagcg gctcgggcaa gacgaacttc ctgtacgcgc tgctgggcag tctcgccgcc
     3421 cggtacccgc cggacgagct cgcgctgtac ctgctcgact tcaaggaagg cgtttccttc
     3481 gccgggctcg cccccggccg caaggacgcg acgtggctgc cgcacgcgaa gctgatcggc
     3541 gtcaacgtga acaccgaccg ggagttcggg ctggcgctgc tgcggttcct ctccgacgag
     3601 ctgcgccgcc ggtcgacggc ggcgaaggag cacgaagtca ccaatctcgc cgggctgcgg
     3661 caagaggacc cggacgggca ctggccgcgg atcgtggcgg tggtcgacga gttccagtac
     3721 ctgttcgccg gccgcgacgc ggtgacgaat caggcgacgg cactgctcga agacatcgcg
     3781 cggcgcggcc gtgcgcaggg catccacctg atactggcga gccaggacgt cgccgggatc
     3841 gaagctttct ggggcaagcc cgcggtgttc gagcagtgca cgctccggat cgcgatgccg
     3901 aaggcgcgcc gcgtgctcgc cgaggcgaac accgcggccg tctcggcacc ccgctggcac
     3961 gccgtgctca accacgaatc cggggtggcg cacggcaacc agctcgcgca cgtgccggat
     4021 gccagcggca aggacgtgtt cgccgcgctg cagcggcgcc tgtgggacgc ctacgccgac
     4081 gagcacgacc ggccgcggct gttcgacggc gcgcattcgc cggtactgga gcacgtgccc
     4141 gcgttcggcg agctgaaacc gggcggcgcg gtgaccgcgc tgctcggcca gtcgatcgat
     4201 gtcgaggaca ccgcctgcgg gatcgaactg gcgcacgcgc cgggccgcaa cctggccgtg
     4261 ctgggcaccg cggcggccga ggcgctgtcc attatggact ccgcggcacg gtcgctggcg
     4321 cgccagtacg agcagggggc ggtggagttc ctgctgcgct gtcccgtcga gcggtgcctg
     4381 cccgccgtgg agcgactggc cgaagacctg gtcgcgcacg ggcaccgcgc cgtcgtgctg
     4441 gacgcgctcg caccgacgct cgccgagctg gcgacgaccg agccggagac cgcgaagatc
     4501 ctgctgctct acggcgtcga cgccgagctg cccgtgctcg aagcgaagga accggggcag
     4561 ctcaagagcg ggctcgacca cctgcggatg gtgctgaagc aggggccggg caaggggacg
     4621 cacacgctcg gctggtggcg cggcacggcg cggctcaagg acaccctcgg gttcggcggc
     4681 aacgacgaca tcggcgcgtg ggccgcgctc gacgtgcagg gcagcgagct gaccccgttc
     4741 gcggcgggcc aggtcgtgca ctggtcaccg cgtccgggca gggcgctgta cttcgaccgg
     4801 agcacgcacg ccacgcccga ggtgatcatc ccgttcctcc ggcccgatcg ggagaacccg
     4861 tgagctctga cggagtgacc gccgcgatgc ggtacaagga catcgtcgcc tcgctgtcgc
     4921 gggcggacga ggatctgcgc gcctgggagc agaacagggc gatcgaactc gaaggcgcga
     4981 tcgccgatgc ggccgcatcg gtcgaggcgg cacgcgagcg ggaagagcgg gcgacccagc
     5041 gcgcccagca ctggtggcgg atggccgcgg acaacgtgtc ccgccttccc tggctcgaac
     5101 tcgacgagcc acccggcccg gatcccaccg cgcggtacga ctggctctcc cggtacgtcg
     5161 acggcgtcaa accgctctac aacgatctcg tgcaggccgt gctccagctc ggctggcgcg
     5221 cccgccgctg aaccgagcga tgcaaacgca tcgcatcgcg agatcgcgca ccgcgcgaaa
     5281 ctcccgcacc ccgaagcagg ggtcactcca cccggcgcgc ccgccgcaca ctcgtcgcga
     5341 ccgaacccgc gagcagcagc ggcaccacca tcaacaccac cgccacccac ggcagggcca
     5401 ccggcgcccc gcccagcacg agcccgcccg ccagcgctcc cccggcgacc gcgccgttcc
     5461 agctcgcgac ggtcagcgac tgggcggtgt cggccgtgcg gccggcgagc atcgcggtga
     5521 tcgcttggaa cgaggtcggc gcgccgccga aggcgagtcc ccacaccgcg ctcgccgcga
     5581 gcagcacgcc gacgctgtgg ctgccgacgg cgatcacggc gaagcagcag gcggccgtcg
     5641 ccgcgcagca gagcaggacg gcgcgcggat gccggtcgag cacgacgccg accagccaca
     5701 ggcccgccac cgtggccagc ccgaacagca gcagcccggt gctgagcagc ccggcgtgcc
     5761 cggcgcgggc gtagaccggg ccgagatagg tgtagaagag gttgtgcgcc aaggaaaacg
     5821 tgatcaccag tgccagcagc gggcgcaggc cgggtgtccg caggacggtg cgcgggctcg
     5881 cgcgcgtgcc gcgggcctcc cccgccagcg gcgggacgac cgcggccacc caccagagca
     5941 gcggcagcgc gatcaacgcc atcacgacga acacccagcg ccagccgacg aggtcgccga
     6001 gcgcggcccc ggccggcacg ccgagcgcga agccgaccgg ggtgcccgcc atcgcgaccg
     6061 cgagcgcgcg gccggaccgg tcggccggga cgagccgcat ggcgtagttc gcgacgagcg
     6121 accacaggac accggtgatc gcgccggaga cgatccgcgc cagcagcacg agcgcgaacc
     6181 acggggaaac ggcaacgacc aggttggtga ccacgaaccc ggcgacgagc gcgagcagga
     6241 gcttcttgcg cggcagaccg gcggtcatcg cggtgagcgg caccgaagtc agcgcggtgg
     6301 tgatcgcgta caccgtgacg agttgccccg tcgccgacgg cgagacaccg agatcggccg
     6361 acgccgggag caggatcccg gcgggcacga cctcggtgag gcagccgagg aacaccgacg
     6421 tggccagtgc gaggagcgcg ggcagcggca gcttggtggc gcggccgggt ggtgcggcga
     6481 ggttcatgat cgagtcccaa aacaccctcg ggcggcaccg ggccgcgagt ccgatgtcgt
     6541 cggcagaagg aaggcggcag gaggaaagcg gccgggtggc acggcacccg gccgcggctc
     6601 ctacgccgtg tggagcagga ggttgttcga tcccgcgccg gggtcggaga tcttgtcctt
     6661 cgtcgccgcc cctgccaacg cttcggccaa cgcgtccgag gtggtgtcgg gatgcgcgga
     6721 caggtacatc gcggccacgc ccgcggcctc ggcggacgca atcgacgtac ccgaaaccgt
     6781 cgtgcaggcc gtatcgctcc ggctgtccgc ggtcttgatg tccttgccgg gcgcgtagag
     6841 gtcgacgcac ccgccgaagt tcgacgacgc caccctgcgg tcggtcgcgt cggtggcgcc
     6901 gaccgtgatc ccggtggtct ggcgcgccgg ggtgctgtcg caggcgtcgg caccgccgtt
     6961 gcccgcggcc gtggtgtagg cgagcccgag ctgcgtcatc ttgtacagct ggatgtcgac
     7021 gaccgtgccg ccgggacccg cgaagctgag gttgagcagc gccgggcgct tcgcgttgac
     7081 gttgacccag tccagcgcgg tcaggatctg ctcggaggtg cccttgccgt cgcagccgag
     7141 cgtccggacc gattcgaccg acgcctcctt cgcgatcccg aagttcttgc ccgcgatcgt
     7201 ggcggcgacc cgcgtgccgt gcccgttgca gtcggtgccg ctctggttcc ctgccgggtc
     7261 gacggcgtcg aacgccgcgt gcgcgcggcc gccgaagtcc tggtggctgg tgcgcacgcc
     7321 ggtgtcgagc acgtagacgt gcacgttggc ggcggtgttc gggtaggtga accggtggtc
     7381 gagcggcagc gcgggctggt cgatgcggtc ctggccccac gacggcgggt tctcctgcgt
     7441 ggcagccgcg gtgtagacct ggttcgcgcc gacggtgctg acggcctcgt cggagaggta
     7501 cttcgtgtgc tgctcctcgg tgaggtcgac ggagaacgcc tgcgagacgg agtagtagac
     7561 gcggcggagg gtgcccccgt acttgccgat catcgcgttc gcggccgcgg tgaccttgtc
     7621 cttttccgcg gccatcggct tcaggcgcac gatgtacacc gcggtcgcgg cggacgtggc
     7681 gctcgcggga gccgcggtca cggcggccgc gggcagtacg ccgaccgcgg ccgcgaaaca
     7741 gaccgccagc acggcggccc ttggcttgcg cttcatggag aaccccttcg agggtgcggg
     7801 tggatcaccg ccgggaccgg tccgcccagc cccggcggcg aagacatcag tggctcagag
     7861 gccgttgagc caggtgcgga ggtcgttggg cccgctgccg gtgtcgaaac cgacgacccg
     7921 gctgcccttc tccttgccgc tcgcgatgtc gatcagcgtc gggatgtact cgacgttgta
     7981 cttgctcgcg atgtcctggt tcgtcttgtg gtcgctcagg tcgaccttcg cccagatcca
     8041 cttgcccttg tcggcggtgt ggtacttctc caggtacggc tccatgttct tgcacgggcc
     8101 gcaccaggtc gcgtagaagt ccagcaccac gggcttggtc ttggacatct ccatgacctg
     8161 gtcgtagttg gccgaggtca cgtcgacgat ggtgtcgtcc tgcggcgcga gcgtggtcgc
     8221 cgcggcgggg gtcaccgccg ccccgccgac gagcccggcg gtcatcgcga cggcggccgc
     8281 gagcacgcgc atcctgcttc ccattttctc tccttctatt cggtgcggtt accggaaacc
     8341 ggcgcgggct gcgccgtcgt ctggggcccc gactcggtgg cgtatccggc ggcgacccag
     8401 tcttcgatcc cctcgcggta cttgcggacg tcggtgtaac cgagttcgag gaggcgcgcg
     8461 ccgacgaact cgctgttgcg gcacggggtg ttggcgcagt agacgaccac ggcggccgag
     8521 gggtccggca gcaccgacgg ggcgtgcgcg tcggtgaact ccgcggcctg ctcgtagggg
     8581 aagccgggga tgttgcgggc gccggggagg tgctcccgct cgtagtaggt caccggcatc
     8641 gtgtcgacca cgatcaccgt gccctcgtcc atttcgcgct tgagctcttc gcgcccgatc
     8701 agcggcagca tgcccgttcc ttccttggtc cgtcggcggg ccgggaagag ccggctcgcc
     8761 gcgaggtagc tgacgaaagc cacgaccacc gaattgatcg cggggatccc gaagtcgaag
     8821 aagacggcga acgccgtgcc cagcgcccag ctgacgagcg cggacggcat ccagtcgcgg
     8881 tgcgcgcccg gcgcggaacc gtgttcgcgc aaggcgtcga acacgggacg gcagcgccgc
     8941 acgacgaagt actccgcgat cagcacgccc gccaccggcg gggtgagcac gccgaccgcg
     9001 gtcaggaagc ccgcgaagtc gtcggcgatc ccgaacgcgg acgcggccgt gccgagcacg
     9061 ccgagcacga gcaccacgtg cacgcgggcg accttgcggc cgaacagcac gtccacgacg
     9121 ttgaccaggc cgagcgacga ggagtacagg ttccagtcgt tgatcttgag gatcgcggtg
     9181 gcgagcacga gggtgccgag cacgcccgac gacgaggtga tgatgccgac gatgtcggac
     9241 gaagccgtgg cgtgcgcgag cagcacgccg atgagcccga tcaggtactc gccgagcgtc
     9301 acgctgatca gggtctgctt gaccacgtcg ccgggagtcc ggttgaaccg cgtcatgtcc
     9361 ggggtcatca gcgcgccgag gatgaacgcg cccgcgacca gcgtggtgcc cgcgccgagg
     9421 gacagcggcg gccccggcgg cgggccggaa accagcgccg gcagcgaatg gctgccgagt
     9481 gcgtccacaa tggagtatcc ggccagcagc aggaacgcgg gcacggtcag gtacgcggtc
     9541 caggccatga tgcggaagcc gtagacggtg atcgcggtga tcacgacccc gccgagcacg
     9601 gcccacgccc attccggcac ggcgccgccg agcgcgtgca tgccgtgcgc gaagatcccg
     9661 ttctgcacgc cgaaccagcc ggcgaggctg atcgcgacga gcagcccgac gagcgcggac
     9721 cccttgcggc cgaacccggc ccagcgggcg agcacggagg tggacagtcc ttcgcggacc
     9781 ccggcgatgc cgagcaggac ggtgatcact tcgagcagca ccgagccgat cgtgatcgcc
     9841 agtaccgcgt tccagaacgt catgccgtag ccgaggatcg cgccgacgat gaactgctgg
     9901 aacgaggaca cctggccgaa gcgctgcacc gcgaccgacg gccaggaccg gcgctcggcc
     9961 gcgggcaccg gggtgagcga atagtcgtcg tgacggtcag tcatcggttc gccgcctcca
    10021 gcacgggttc gcggaccacc aggaatccct gccccgcgtg cggccggaac gagaattcgc
    10081 ggtcgaagaa ccgttgcagg aaaggcacgc gctggtggta gacgaacatc gaaccggtat
    10141 taccggtgat cgttccggac gccgcgaaca acggcagttc ggcgaggaag tactgaacgg
    10201 ccagccgcag tctcgccgga ttcgacccgg tatcggtttt cccttgcagc acccaggaag
    10261 aagcaccata gcaggccgcc cgaaaaacgc ggtcggattc gaagcgttct tccacttcgt
    10321 tcgccagcct gcggtacgcg agcatgtcgc ggagccgcgc catgccgagc acgcggctcg
    10381 ccggatcggc gatgccgatg gcggtgagcg ccgcggtgat cttgttgtgc acgtggcagg
    10441 cctggcggtg cgccttctgc ttcgcccgtg cgggcgggta tcccatcgct tcgagcgtgt
    10501 acgccgtgac gtcgtccggc acgaagaaat ggaattcggc gaagttctcc gcggtccacg
    10561 cggcgagccg gatgagccgt tccgcggtga aataaccgtt gaacgggctc acgccgacgc
    10621 aggcgtgcgg cacgtccgga aacaaccggg cgcagccgga cgagagggga ctcgcttcga
    10681 acatggagga ttcgccacct ttcccttgct ttcccctggc ggtcccgaac gggtctgctc
    10741 actgtggccg agatcggcac gcgcgggtaa tgccgaaggg ttatgcctcc ggcgcggcgg
    10801 tgaccgtgcg aattccctac tttggtcggg tggcgaccac cctttcgcag gtgcaaccgc
    10861 gggcgcgcct gccatacggt gatcaccgtg gagctggaac tgaagcatct gcaccacctc
    10921 cgggttgtcg cgaaagcggg cagcctgaac cgcgccgccg cccaactcgt cctcccgcag
    10981 cccgcgctca gccgcgaact gcggcggatc gaacaactcc tcggtgacga actgttcgaa
    11041 cgcgaccgca ccggcgtgcg gccgacggcg ttcgggcagc tgatcctcga ctacgcggac
    11101 gggatactcg cccacaccgc gaagatcggc tccgatctcg cgcaccagtg cgcccatcgc
    11161 acgaaggcgc tgcgcgtcgg ctggtcggcc accgcgctgt ccggcctgct gctcgacgcg
    11221 ctcgacgtca ccgggtacgg cgaccaggcc gagatccgga ccgccgagtc caccgcggag
    11281 atgctcgaat ggttcggccg cggcgaactc gacctcgccg tcctttcgga acagtgcgag
    11341 gtaccgctcc cggcgaacac gggccgcgtg gacctttccg acgaccccct gctgatcatg
    11401 ctgcccgact ggcatccgct ggcgtcgcgg cagtccgtcc agctcgccga gctggaacac
    11461 gagcggtgga tctcgtcgac ggggccggac cgctgccgcg agttcctcaa gcgcgtgtgc
    11521 cgcccgttcg ggttctcacc gcagatcgcg caccacgtgt cggtgtcggg tccgcgcgac
    11581 gaaatcgtcc gctaccaggg cgacgtgacg ctcgtgcaga cgttgcgccc gctggcgccc
    11641 ggcgtggtgc accggccgat ctcggacctg ctcatgcgca ccagccattt cctgctgtac
    11701 cgggaggaca gtccgatcgc ggcgcggatc gacgtgctcg ccgggctgat caccgacgcc
    11761 tactgggaag ggcgccgcgg tgagcgcgtg ccgtcgcgga cgttccccgc gggcctgccg
    11821 cggctcgcca cgcgcaccag ctgagcgagc gcggtggaca tcgagctgcg gcagttgagg
    11881 atcctcaccg cggtggccga ggcgggcggg ctggccggtg ccgccgtcgc gctgggcatg
    11941 agccaggcga agctcgagca gcaggtccag cggctcgagc gcatggtcgg ggccgcgttg
    12001 ctgcacgacg ggcccgccgg gatcacgttc accgaagccg gcgaggtgct gctcgaacac
    12061 gcttcggtgg tgctgccgca gttcgaccgg atgctggcgg ccgcgcgggc cggtgccgaa
    12121 gcgcccgcgc cgaacgtggt ccggatcggc gcggtcgcga cgccggtcct gccggggctc
    12181 gtccgcgcga tcgacgaagc cgtccccggc gcggaactgt cggtgcggat cgaggaaccg
    12241 ggcacggatc tggccgaagc cctgttgcgc gacgaactcg acctcgccgt cgtgcggcag
    12301 cacccggcga ccgggggcgc gctgccgccg tcgctcgcgt gctcgccggt ggcgaccgaa
    12361 ccgctgttcg tcggcatccc gccggggcac gcgctcggca cgccggtgtc gatcgcgccc
    12421 gccgcgcttt cgggacaccg gtgcgtgctg ctcgaccagt ccgtccagcc gctgacgctg
    12481 gcggtgctcg tcgccttcgc cgacgcgggc gccgatccgc gcttctgcta cgccgccagc
    12541 gaatgggcgg cgctctgcct cggcagcggc accggcatcc tgaccgtgac ggcgccgccg
    12601 acgacgccga tgccgggaac cgcgtaccgg cccgtgcggt gcgccgcggc gatgtcggcg
    12661 ctcgtgctcg cctgggtgcc gggcgggccg gtcaccgact gcgccgcgcg catccacgaa
    12721 gccgcgatgg agacccacgc cgactgcctg cgcgcgctcg ccaccggccc ctgaccacgc
    12781 gccattcgat cacggaattt ccgcgcaatt cgtcatcatt ccacgaatac ggcgcttccg
    12841 aaccgaaatc ggcgttcatt cgggcaatgc cgttgattcc cctgccgcac tactggaaat
    12901 cttcgactcg ttccttcgaa tcaacccacg gagtgtggca aatggctctt tcgcgcaaaa
    12961 tcggggcact cggcgtcctc accgccgcga ccgcggcgat cgccctgtcg accgtcggta
    13021 ccgccagcgc cagctgggtc gcggggacct accacagtcc ggccgactgc cagtcggcag
    13081 ggaactggct ggcccagcag ggcagggccc actacttcca ctgcgactac ggaatcgtgg
    13141 ccggacaagg tccggaatgg acactcgtag tcgagtggtg acgtactgag gaatgcggcg
    13201 gttctcgctg agtcattcga cgagaaccgc ttttcccggt tgcgccggac ggctcaatgc
    13261 ggttcgagct gcgccgcgca agctcggcgg atttcggccg cgaggaccgt ttcgtcctgt
    13321 ccccagtgct caccccactc gtcggcgaac aggctggtcc ggccgagcgg aagccgcacc
    13381 agcccgtcgt cataggacgt cttgagcgcg atctctccca cccgttccgc gacctctcgc
    13441 tcgtcgacga gcccgtcggc gaacaggcgg gcgaagtggg tgaagagcac atcggcggcc
    13501 tcggcgacgg tgtccggagg tgtcaccccg caggaagcaa gcgcttgcgg taggacggcg
    13561 cggacctcgt cgccatccgt gccgtccaac gcggccagca cgacgagcgc gtcggaatca
    13621 ccgaggccgc cggcgagcca gtgcgccgcc catagcggaa cccgctcgac gtggatcagg
    13681 cccaccgcgg caccggcggc gaccagttcc ggcgacggga ccgctcgccc gaacaccgct
    13741 caccgcctcg ggaagacccg gtccagccag tcggccaggt cgtagaaggc gtcgaggacg
    13801 cggtttcccg ccgacggccg gaaccgcacg agctgcgggt catgatcgct ggcctggtcg
    13861 gcgaactcgg cgttgatgtg caccacgtcg tagtcgattc cccgcggcgc gggcgaggaa
    13921 aggatgtggt cgagcacctg cgagttgcct tcgaagacgt agctgtaccg ctcctgcggc
    13981 ggcagcgtgt cgatcagcgc tttgagcccg ccgcccgcgg tgagcgtctg gacggtcttc
    14041 gagaacgggt agtcgttcag gtcgcccgct acgaccacgt tcgccccgcg gtccgcggcc
    14101 agcagcttgc cgacgaaatc gtgcacaagc tgggcctgct gcacccgctg cacctcggag
    14161 ctccgggtcg gcggctggta ccggccctgc gtcggctggt cgccgccctt cgagttgaag
    14221 tggttcgcga ccacgaacac ggtgcgcccg ccgaacacga actcgcccgc gaggggcttg
    14281 cggctggccg tccacgccgc gttccccggc tcgacgcggc caggtgagat cgacagctgc
    14341 ggcttgccgt gcacggtgtt caccgcgacc ggcgtggtcg cgtcaccgcc gggccggtcg
    14401 acgaacgaga cgcgcgcggg gttgaacagg aacccgacgc ggatgttgcc acccggctcg
    14461 ccgccgtcct tcttgtcttc cgggtcgatc tcgcgccact cgtagtgcgg gccgcccgcg
    14521 gcggcgatcg cggcggtgaa ccggttcaac gtctcgtcgg cggccaccac gccgtcgccg
    14581 ttcccgtcgg cgccgttgtt gtcctggatt tcttcgagcg acacgatgtc ggggttcgcc
    14641 aggttgtcca cgacgccgtg cgcgagctgg tcgaacttgg cctggtcgtc gaccgcggac
    14701 aggttctcca cgttgtaggt cgcgaccgcc agctcaccgc tgcgctgctt gcgggtgact
    14761 tcccgctgca ggccgttgtc cttgacctgg ccgagttcgc tcgcgaagag cgtgtagccg
    14821 ccgaagctgt cgaattcgag cgggcccgag gtgcggccgg tgagcacgtc accggtgttg
    14881 gccttcggga acgggcgctg cgagaacgga atgatcgact cgaccttcag cacgccggtg
    14941 ttctgctggt cgtacccgcc gtagagggtg ccgccgcgcg gggtcgggcg ctgctccggt
    15001 ttcgtggtca cgtacagctc gccgtactcg gtgctgcggc cgacgatgcg ggcgtcggaa
    15061 acgctgacga tctcgctttc gtgcgcttcc cagaagtcga gcgcgtactt cgacggttcg
    15121 agggtcagcg gttcgatgtt gccgcctgcc tgtggcgcga gctgcgcggg cacggtgtcg
    15181 ggagccagca ccgtcggtgc ggggagcggg ttgcccgagg atccgaccgt ccacttcgca
    15241 ctcgtcagct cggtgagcga ctggtacttc gaggtggcgg gcgcgtccgg gtagaactcg
    15301 cgaacggtgc cgctcgccgt caccgcgtcg ccgacggcga ggtcgggcgt ggtcgacccg
    15361 gtgaacacga acaggccctc gctggtgcgc ggatcggcgt cgggcaccgg gtcggtcatc
    15421 cagaaaccgc gagccgagcc gaacgtccgc agtgcggtca cgacgccggt gacgtcgctg
    15481 acctgcttgt ccttgaacgg tgagaggcgg gtgacgccct ggatgtcgtg gatcttcgcg
    15541 ggggtgccgg gctggccggg gtcgccgccg ggggtctcgc ccttggcgtt cgtcggagtc
    15601 ggcgcgccca cggcgaagtc ggccgcgttg tcgtcggtgt cggcgagccg cgcgccgcgt
    15661 gccaccgagg tggtgttggt ggtcgccgcg gccgcggtgc cctcgcggac ggccgcgtcg
    15721 ccgtatccga cgagatcgcg cacgttcgcg tccgccgcgc agtctgccgc ggtgcggcag
    15781 gtcagcggct gggtcgtggc gacgagcgcg acggtgcccg cggtgccgga caggttgatg
    15841 ccgccggtcg cgtcggcggc gggcagcgcg gtcgtgccgc tgttcccctt ggcctccgcg
    15901 accaggtagc ggccgccggg ccgcacggcg ccggtgagcg gggtgacctg ccatttgctc
    15961 gtcgggcccg gagccgcggg caggtactgc acgctccagc cggtgaggtc ggccgcgccg
    16021 gtgcccctgg tggccagctc gacgaagtcg ttggtcagcg tggcgccgct gttgccgccg
    16081 cccccgtaca cctcggcgag caccgcgccg gtgctcgggg tcgcggcggc ggggacggcg
    16141 agactggtca ccgtcagcac catcgcgccc gccagcacac ccagtttccg gcgatatgtc
    16201 acgctgcgtc cccttacgtg agaagcggtc gaggcatgtt cccccgatcc ggcgagcaac
    16261 ggtacgtcga agcggcaacg attcgtgata cttccgctga actgatccac cgcgagccct
    16321 cgaattggcc cagtggtctt ggtcagtatt ggaacttcta cctggtcaat cggcgaccta
    16381 cggttacccg cgtgacttcc gcactggttc ctcccgcagg cccgtcccgg gtgctcgcgg
    16441 tggcgcagct gaccaactcg gtcggcgacg gggcgtacta cgtgacgtcg gccctgtact
    16501 tcaccagggt catcggcctc tcccccgccc aggtcgggct cgggctgacg atcagctggg
    16561 cggtcgggtt cctcgccgcg accccgctcg gccacctcgc cgaccggcac ggccctcgcg
    16621 ccaccgcgat cctgctcgcg ctggcgacga gcgcgttcgt cggctcgttc ctgttcgcgc
    16681 ggtcgttccc ggcgttcgtg ctcgtcgcgt gcctttacgc gagcagccag tgcgggctca
    16741 ccgccgcgcg gcaggcactg ctggcggggc tcgtgacggc cgccgagcgg accaggatcc
    16801 gggcctacct gcagtccgcg accaacgcgg ggctcgccgt cggcgcggcg ctcggcggga
    16861 tcgcgctgcg cgtggacacg cccgccgcct acctgaccgt cttcggcatg gacgccgtcg
    16921 ccttcctcgc ctcggccgcg gtcctccggc gagccccgca cgtgccgccc gcgcccgccg
    16981 tgacgggacg cgagccgaag ctcgcggtac tgcgcgacgc gccctacgcg gtggtgtcct
    17041 tcctgaacat gctgatgctg ctgcacatcc cgctcatcgg gctcgcgatt ccactgtgga
    17101 tagtcgagcg gacgcaggcg ccgacctggc tggtgtcggc gatgctggtg ctcaacacgc
    17161 tgagcgtggt cgcgttccag gtccggatag cgcgccgggt caccggaacg gcgacggcgt
    17221 cgcggtcggt ccgccgagcg ggtctggtgc tgctcgcttc gtgcgcggtg ttcgcggtat
    17281 cggcggcggg cggctcgccg tgggtggccg cggcggtcct gctcgtcgcc gccgggttgc
    17341 agacactcgg cgagatgatg cagaacgcgg gtggctggga gatcgggttc gcactggcac
    17401 cggccgggaa acagggccag taccaagggt tcttcggttc cgggttcgcg gtcgcgagga
    17461 tgctcgggcc gctgctgctc accacgctcg tgctgtcctg ggggccgctc ggctggctgc
    17521 tgctcggcgg cgtgttcgcg gcggcgggcg tcgcgatggg cccggcgacg cgctgggcgg
    17581 agcggacgcg gcaggacgcg gacaccgata gtccacagag gacccggctc gtcgggtcct
    17641 ctgtggacgg gtgatcagaa cgggcggtcg ccttcgatcg cgacgcgttc ggcgacgcgg
    17701 ggatgcgggt ggtagtcgtt caccgcgtag tgctgggtcg cccggttgtc ccagaacgcc
    17761 accgagttct ccgcccactt gaaccggacc tggtactcgg gcacgtgcgc ctgctggaac
    17821 aggaaccgga gcagccggtc gctctcgtcg cgcggcaacc cgacgatgtg cgtggtgaac
    17881 gcctggttca cgaacagcgt gcggcgcccc gtttccgggt gcgtgcgcac caccgggtgc
    17941 tcgaccggcg ggtagtcgtc ctgccacgcg gcgagcagcg cgggatcggc gaaccggtcg
    18001 aaccccggca ggtagtcgtg caccgcggtc cgcccgtcga tccgctcgcg gacctccggc
    18061 ggcaggttgt cgtacgcggc cgccatgtcg gcccacatcg tgtcgccgcc gactggcggc
    18121 acttcgacca ggcgcagcac cgagccgagc gccgggttcg gccgccaggt gacgtcggtg
    18181 tgccagatgt tctcgtaccc cggcatcgac gcgccccgcg tgaaccgggt gacctcgtcg
    18241 gtgtcaccgg ccgggatgaa cgggttcgtt tcgagcgggc cccagtgcgc ggcgaacgcg
    18301 cgctgctgcg ccggggtgat ccgctggtcg cggaagaaca gcaccttcca ctccagcagc
    18361 gcgcggttga gctcggcgcg cagttcgggg gtcagctcgg tgccgaggtc gaaaccgtgg
    18421 atctcggcac cgatcacggc accgagcggg cgcaggtcga acaggtcgta gggacgcggt
    18481 tcggcgccgg ggaggcggcg caggacgcgc gggccttcga ggatcccgcc ttcgggcacg
    18541 gtggcctcgc gcagggcagg ggcggacacg tcaacggaca cggtggtacc tcactgtcgt
    18601 tcgagggaat ttcgtttcgg tgcgggaaaa agggctactt cggcggtgag ccgaggcggc
    18661 cgcgccgcac gagcagggcg gcgacaccga aacgaaccga gcgccaggga aggcgacgcg
    18721 gacacgggac agctgcgtgt tcccgaacgg ttgacatgcc tcgatgatca gccccgcgcc
    18781 gggtcagcgt caaggcttcc agcatgtgga cgggcaccgc gctagaccat ccggcccaac
    18841 ttcgcgcgaa cgcgtgtggg cggcaccagc gggggtaacc gaagtcaatc acgttgggag
    18901 aagggagatc caccgatggc cgactccgcc ctcggcgcga ccgaagcgct ggcgaaggca
    18961 cgcaaggccg cgagcaagct caaacgcaag gacgcggcgg tgtactgggc gaccgtggcg
    19021 cagaccgccg tgctgaccga gatccgcgac gaactgcgcg cgctgaacca gcactccggc
    19081 ggcgtcacgc tgccggacga cgctcccgcg aaacggcgca cttccgttgc ggtgcaagaa
    19141 ccctagcgtc gtccggtcca ctccgttccg ccgcggtggg cgggcgccgc gcccgctggt
    19201 gagcgggggg ggaaccggcc ctttccctta tttccccagg gaaaacgcgt cgaagtcgtg
    19261 ctcgttggac gggccgcgca gggcccacag gcgcccgtcg tgccagaagt actggaagtc
    19321 ctgggtgatc ggggcgccgc cgctcggcgt ggccagcggg taggtctcta cggggccggg
    19381 agcaccgtcg gccagcgaga accgcgcgat ccgctggtcc ccgcttggcg tcgccgggga
    19441 caccagcacc accaccgagt cgccttccac cgcgagcggc atgatcgcct tgccgtcggc
    19501 gaggggccgt tcccacttct tcgccccgga cgcgatgtcg taggcgacga gcttgttggt
    19561 gccgttgagc gggatcgcgg tgaccgtgac gaacagcccg ccggagatca ggaagcggcg
    19621 gcctggctgg cggttgtcca ccgcgtcgac accggcgccg tcgcccgcga gcgattccgc
    19681 ggtgccgggg tgccccgcgt cgatcgtccc gaccttgtcg aacttgtcgt ccatcacgat
    19741 gtagacggcg tcctcgacac cgcggttgac cagcgccacc ggcgggtcgg ccgacagcag
    19801 gcgcggggtg gcgaaccgct ggctgctgtc cttcgaggtg tagtcgacgc cctggctcag
    19861 cgtgccggtg gcgggatcga gcgtggcgaa ggtgatcgcg ggatcggaga tgaacccgct
    19921 gagcgacacg accagtgact gctttcctgg ccgcatgccc atgatcgcgc tgctccccga
    19981 gtcgccgccg gtcggcttga ccacgggctt cacccagcgc cgctgaccgg tggcgaggtc
    20041 gagaccgacg gtcccgtact tctgggcgag caccacgacg tcacccatga tttccagcgc
    20101 ggcgccggtg ggcttgctcg ggctcgaacc ctgcggcgcg tcgaacggct gctgccagcc
    20161 gagctgcccg gtcttcacgt tcagcacggc ggcgaactgg cacaccgggt ccttctgctc
    20221 ggtcagctcc ttgccgtagg cgacgggcag ctggtcgccg accaccctgg tgcccgcacc
    20281 gcagaacttg ccgccctccg gcgcgggtgt ccgccacgcc tgcttgccat cgcccttggc
    20341 gaacgccgtg atcgcgcctt cgtgcgcgac gacaaccgtg tcaccgacct cccacgaccc
    20401 gagccccttc tcgtgctcgg gacggtcgag gtgcacctgc cagctcttcg acgcgggctg
    20461 ctcggggccg cccgcccgcg ccggcgcggg gtccgaaccc gaggtgagca cgatcggcac
    20521 caccaccgcg gcggcgacca cgacgaccag caggggcgcc agccacagcc agaacttctt
    20581 gttcttcggc ttctgcggcg gcggtccggc gggcggctgg taccactgct gctgggggta
    20641 ctggccttgc ggcgggtacg gcccctgcgg gaaaccgccc ggcg
//
