LOCUS       NZ_CP059997            21053 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1887561
            Orig. end                         :: 1908614
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="11"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11053](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11053)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            complement(152..1039)
                     /locus_tag="HUW46_RS08945"
                     /old_locus_tag="HUW46_01792"
     CDS             complement(152..1039)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014467603.1"
                     /locus_tag="HUW46_RS08945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01792"
                     /product="hypothetical protein"
                     /protein_id="WP_215546850.1"
                     /transl_table=11
                     /translation="MPRTTWEGLPALVRAVIERECGRVLRAEEPSAGRNSDFSATVYTD
                     RGPVFCKGITDAHGKRGAMHRHESMINKWLPHEVAPRLLWQAEADGWLLLGFEHVAGCH
                     ADLSPGSPDLPLVTEAMTTLARELAQCPSGVPSLADKMAWLAGWRRLRHDPPAELDNWS
                     REQLDLLVEWEARGLEAVAGDALLHTDLHSLNILVADRARVIDWAWARSGAAWTDTAHL
                     VVRLIDAGHRPSDAERWAAGIPGWQDVSGTELTGFAVALAGMWTYLRHADPQPQRPRLA
                     GSARTWAEHRLRTE"
     gene            complement(1048..1527)
                     /locus_tag="HUW46_RS08950"
                     /old_locus_tag="HUW46_01793"
     CDS             complement(1048..1527)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229068.1"
                     /locus_tag="HUW46_RS08950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01793"
                     /product="hypothetical protein"
                     /protein_id="WP_215546851.1"
                     /transl_table=11
                     /translation="MTSVLTGRATGRSLVSPELFDRLARRIVGEEKLDRDLAERITEQT
                     LAFLVACAVNTGSPLAPSELVDVGWHTFLLHTKDYAAFCERIAGRFLHHVPTDENDPAA
                     RGEAARETLSRTVAAIKSSGLAVDPALWPAVGSQCNVDCSQCQNGCSDDPPPACR"
     gene            1675..3156
                     /locus_tag="HUW46_RS08955"
                     /old_locus_tag="HUW46_01794"
     CDS             1675..3156
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020634937.1"
                     /locus_tag="HUW46_RS08955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01794"
                     /product="peptide deformylase"
                     /protein_id="WP_254125966.1"
                     /transl_table=11
                     /translation="MADPAGDVNAFAVELERWRDVRGHSRAALAKAMGYDRSYVSKVLS
                     GAERPSEAFAVHAETALRAGGALRAAFREYEARRPARPRPQAAPAVADPPAGTGGIVVD
                     HDDAILRYDEGVYRLTQRRRLVNEGGEPISRYLIRISVDRYPGDPERSNQLYSENPLTW
                     DEIELRAWHGRGRSTAMTWTPHHDRDAFKEVWLLFEGEQGHFPLYPGEACWIEYEYTVR
                     DEHWGNWFQRAVRLPTRTLSVCLDFPADLAASVWGLHTSMTSQAMPFATAIKRDDDGDR
                     HVFSWSCEDPPLHARYRLEWGFRSDTAATGPAPTAVMASLGIVQDSDPALREPARRFAL
                     PSEAEDAHRVVAELKAAAERVARAHTFGKGMGIAAPQIGVNRAAAIVRTPDGEVITLFN
                     PRIIETAGEIDEQYEGCLSFFDVRGQVPRAHTIQVEHTSADGRTKITAFDKGVARLVAH
                     EVDHLHGTLYTDRMREGVSPIPVEQYRGTGSRWKY"
     misc_feature    complement(1696..1707)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     gene            complement(3196..4188)
                     /locus_tag="HUW46_RS08960"
                     /old_locus_tag="HUW46_01795"
     CDS             complement(3196..4188)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025878.4"
                     /locus_tag="HUW46_RS08960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01795"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_215546852.1"
                     /transl_table=11
                     /translation="MRAQGAEPAFAVHRVAETADVAVANEAIERVYLPNRIDLLDPATP
                     LDMRLNAVRLAGVTVGYVRFGSDVRVVTGDCASYHVNVPLSGAVESRSGNRGPVRGSPR
                     RAAVFTPGAPADLRWRADCAQLCLMIPAETLRERLAKHLDRPVTGAPDFAVAMDLGSGA
                     ARELLDLLRLLDRETAKPDGVLRQPLAAATLRDQVIDAVLRAQPHTYSAELTEKAHEAA
                     PRVVRHAIELLRETPEFPWSPAELAAAVAVSVRSLHDGFRRAIGRPPMAYLREVRLGRA
                     HADLLAAEPGAVTVTEVAGRWGFAHLGRFSVGYRDRYGERPNETLRRLP"
     gene            complement(4260..5939)
                     /locus_tag="HUW46_RS08965"
                     /old_locus_tag="HUW46_01796"
     CDS             complement(4260..5939)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641817.1"
                     /locus_tag="HUW46_RS08965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01796"
                     /product="L-lactate permease"
                     /protein_id="WP_215546853.1"
                     /transl_table=11
                     /translation="MGWVQDYQPAGGLWPSALLAALPIVVLLVSLGVLRRSAHLSAALA
                     LLTALAVALALYRMPVGLALDSAAMGVVFGVWSVAWIAFHAVYFHNVTVATGRFDSIKT
                     VLAGFSEDRRLQALLIAFGFGALLEGVAGGGSPIAITAAMMAALGFPPVKAVVLALLAN
                     TAPVAFGGLGNPLIVLGRLTAPIVHLKPDQATDLFSSMVGRQVPWLAVIIPAFLVVVLA
                     GWKRMLEVLPAVATAGITFAALQFVVSNYVSPSLVDVVAALGAMASLWILTRFWQPKTV
                     WRFDGEEPVAAATGAPKAGPFHAWLPYVILIAAIFASRIGTIFKDLPPWLDLTKLLHKA
                     DWVFGWPGLDKAVVQHAPITPKDTPYAASFTVDFLFSPGTVALAAALIAGFAMGAKPGL
                     LARTYRRTVHQMRWALATIFMILAIAFVMNYSGATQTLGLALAATGALFPLFSAYIGWL
                     GVFLTGSDASTNSIFGPMQVISAQQLHLDPTLAGATNTSGGVMGKMISPQNLSIGATAI
                     GQSGKEGTLLRQTFLWSLVLTGVVGVLALLQASVLSFMIPTP"
     gene            complement(5942..6727)
                     /locus_tag="HUW46_RS08970"
                     /old_locus_tag="HUW46_01797"
     CDS             complement(5942..6727)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641816.1"
                     /locus_tag="HUW46_RS08970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01797"
                     /product="IclR family transcriptional regulator"
                     /protein_id="WP_215546854.1"
                     /transl_table=11
                     /translation="MDCEHGTFERSGTLERGLAVLRHVGLKQEISTNAIATQLGLSRSA
                     VYRIVNTLKQLDYLEADHVTGRVRLGTRLVELGVRAMSSSDLHRAAPRFLAALAEKSGE
                     TTYLAVPDGNAMVYVATEQSAGAVTLKCRLGARRPQYATSLGKAYLSALSEVDRVERLR
                     RMKLDRLTGNTIVELPRLLDELVTARRQGWALDDVENEPGVGCVAAPIRDRSGAPVAAM
                     SVAGPAERVLPRRGELAGLVVATAAALSRRLGHVPAQGA"
     misc_feature    complement(6857..6871)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.81"
                     /tool="antismash"
     misc_feature    complement(6915..6930)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.33"
                     /tool="antismash"
     gene            complement(7026..7376)
                     /locus_tag="HUW46_RS08975"
                     /old_locus_tag="HUW46_01798"
     CDS             complement(7026..7376)
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00377.1"
                     /locus_tag="HUW46_RS08975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01798"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_215546855.1"
                     /transl_table=11
                     /translation="MEIPLPRLPDGHGLSVTESQYDDRTVLTVVGEVDAMTVDALRAHL
                     DRVATSELVLDLSRVGFLSCAGLQALVEVRGRGVEVSVVITEHIVWRVFEATGLASLFA
                     VHAKLDTAAAPR"
     gene            complement(7553..8293)
                     /locus_tag="HUW46_RS08980"
                     /old_locus_tag="HUW46_01799"
     CDS             complement(7553..8293)
                     /NRPS_PKS="Domain: PKS_KR (3-164). E-value: 7.3e-13. Score:
                     40.8. Matches aSDomain:
                     nrpspksdomains_HUW46_RS08980_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016332574.1"
                     /locus_tag="HUW46_RS08980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01799"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_215546856.1"
                     /transl_table=11
                     /translation="MTSTVLVLGGRSEIGLEVARGLAAEGRTIVLAARRSHDLDAQEDA
                     LRAAGAGAVKRVEFDADDLASHLPLLEDVATRFGPLDVIVTAFGILGDQQRAENDAGHA
                     VAVVHTDYVAHVSVLTHAVNLLRKQASGTVVVFSSVAGVRVRRANYVYGSAKAGLDGFA
                     SGLADALAGSGVRLLLVRPGFVVGRMTEGMSPAPFSSTPAQVAKATLGALRRGCGEVWV
                     PGVLRPVFAVLRLLPRALWRRLPR"
     misc_feature    complement(7562..7564)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(7802..8284)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS08980_PKS_KR.1"
                     /evalue="7.30E-13"
                     /label="HUW46_RS08980_PKS_KR.1"
                     /locus_tag="HUW46_RS08980"
                     /protein_end="164"
                     /protein_start="3"
                     /score="40.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVLGGRSEIGLEVARGLAAEGRTIVLAARRSHDLDAQEDALRA
                     AGAGAVKRVEFDADDLASHLPLLEDVATRFGPLDVIVTAFGILGDQQRAENDAGHAVAV
                     VHTDYVAHVSVLTHAVNLLRKQASGTVVVFSSVAGVRVRRANYVYGSAKAGLDGFAS"
     CDS_motif       complement(8189..8284)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS08980_0001"
                     /evalue="7.10E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="HUW46_RS08980"
                     /protein_end="35"
                     /protein_start="3"
                     /score="15.5"
                     /tool="antismash"
                     /translation="TVLVLGGRSEIGLEVARGLAAEGRTIVLAARR"
     gene            8337..9365
                     /gene="mgrA"
                     /locus_tag="HUW46_RS08985"
                     /old_locus_tag="HUW46_01800"
     CDS             8337..9365
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0047834 - D-threo-aldose 1-dehydrogenase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="mgrA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457283.1"
                     /locus_tag="HUW46_RS08985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01800"
                     /product="L-glyceraldehyde 3-phosphate reductase"
                     /protein_id="WP_215546857.1"
                     /transl_table=11
                     /translation="MTYVAANSRYDTMPYRRCGRSGLKLPPISLGLWHNFGHDKPFETQ
                     RAICRRAFDLGITHFDLANNYGPPYGSAEENFGRLLAGDFAPYRDELVISSKAGYDMWP
                     GPYGDWGSRKYLLASLDQSLKRMGLDYVDIFYSHRFDPETPLEETMGALDTAVRSGRAL
                     YAGISSYSSEKTAEAVRILRDLGTPLLIHQPSYSMLNRWTEADDLLGTLDEAGAGCIAF
                     SPLAQGMLTSRYLDGVPPDSRAAAGKSLNPGTLTEETLAKVRALNEIARRRGQTLAQLA
                     LAWGLRDPRMTSVLIGASSVGQLEDNVAALGNLEFTDDELAEIDRHATDANINLWQRSS
                     AH"
     gene            9460..9987
                     /locus_tag="HUW46_RS08990"
                     /old_locus_tag="HUW46_01801"
     CDS             9460..9987
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020642965.1"
                     /locus_tag="HUW46_RS08990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01801"
                     /product="serine/threonine protein kinase"
                     /protein_id="WP_215546858.1"
                     /transl_table=11
                     /translation="MNDEVSVSALLAREGWGEHLPPRPRSRWRVMAVMAAVVTGCGAAA
                     VAVNVSSPSDDRADDPLIVQPPPPTSGTGEETTAVPTAPPSRRGGSGGGEPSTAASTSE
                     SPSRTGRTSAKPTTAAHPSTEDPAPTGHPEPSRPAPPTTGGGGTSTRPAPPPPPTTSTA
                     PPCTMWPEWLWC"
     gene            complement(10001..11053)
                     /locus_tag="HUW46_RS08995"
                     /old_locus_tag="HUW46_01802"
     CDS             complement(10001..11053)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666922.1"
                     /locus_tag="HUW46_RS08995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01802"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_215546859.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4e-62, bitscore:
                     209.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVTSDLTGLPVATGRPVRALLEWSRGLLDPALREAVDSMPGSMRL
                     IAGYHFGWLDERGKPAKESAGKAIRPALTLLSAQAAGGDPAGAVPAAVAVELAHNFSLL
                     HDDVMDGDTTRRHRPTVWSVFGTPAAILAGDALLTLAGDVLASTGSAVAAESARMLSAA
                     VLELVEGQSADLSFERRRDVGLAECVRMAERKTGALLGCACALGAAAAGSVAAGAGHLR
                     SFGDRLGLAFQFVDDLLGIWGDPAATGKSVYSDLRSRKKSLPVVAALTSDTDAGREFGQ
                     LYHRPDPLAVDDLVRAARLVDAAGGRAWCRDQASALLADALAELRACDPDPKAEVELTA
                     VAHLMVQRTG"
     misc_feature    complement(11245..11259)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.42"
                     /tool="antismash"
     misc_feature    complement(11246..11255)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.9"
                     /tool="antismash"
     misc_feature    11273..11284
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.75"
                     /tool="antismash"
     misc_feature    11281..11296
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.88"
                     /tool="antismash"
     gene            11912..12679
                     /locus_tag="HUW46_RS09000"
                     /old_locus_tag="HUW46_01803"
     CDS             11912..12679
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644038.1"
                     /locus_tag="HUW46_RS09000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01803"
                     /product="hypothetical protein"
                     /protein_id="WP_215546860.1"
                     /transl_table=11
                     /translation="MSIYLSGLLWVVGAAAAGAGSAYLVRRFGLSEGRPDNNDAAGQVF
                     TIVSGLQAVIVAFVLISQFDAVDAARDGAFKEANAAVAASWAADALPEPTRGEVREQAA
                     AYARTVQDVEWPQMRAGHTVESDGWAQLARLRDTVADAQTADGDDWATDRKTEAANQLW
                     DVYQARQERITGAVQNGLGAVLWFVLILGSVVTVLMPNLFGGTKPRTHIIIVSTLAGTI
                     TVLLFAIYQLQNPYAGGTKIEPDAFRWALDRLS"
     gene            12683..13996
                     /locus_tag="HUW46_RS09005"
                     /old_locus_tag="HUW46_01804"
     CDS             12683..13996
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS09005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_01804"
                     /product="hypothetical protein"
                     /protein_id="WP_215546861.1"
                     /transl_table=11
                     /translation="MPSARRAFPLAASALLLGALAFLPTAAGAREPETCTAIEVRSRLP
                     TDLSSAYRVELPSGAVTALGRLDYRVNALGYAKAQNLAYGLADFASRWPTPGAPRVVTI
                     ARDGTVRDRGPIRRGPHPGLGPALVSATAGAIVGNRWYVKRIGTLYTVDIDPASATYLS
                     VVHATRLRPLGLAAKVDDFDLDPASGLLVGVAADAHEPGALVSLDPVSGAVRRLPGPRL
                     PASSAYGAVVALGGGTLSVLANDVRGRGRRYLVPPNGTPVEIDAGPALSSSDGAGCFTA
                     PPPPTTPPTTPPTTPPTTPPTTPPTTTPTTPPTTPPSTPPSSPPAPPPPPPKATPPPSP
                     VPVPPPASEPEPVTPAPPPPPPLPTAEPVAPAKPAPPSPRPTTKKPAQARPTPSKSADA
                     GPTRLERTKEKRRWGVAVLLMTIGAAAVTRSAARHRSR"
     gene            complement(14002..15354)
                     /locus_tag="HUW46_RS09010"
                     /old_locus_tag="HUW46_01805"
     CDS             complement(14002..15354)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644039.1"
                     /locus_tag="HUW46_RS09010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01805"
                     /product="esterase-like activity of phytase family protein"
                     /protein_id="WP_215546862.1"
                     /transl_table=11
                     /translation="MRRLAIAAGLVVSLSAAGTASAHGDRLRDAVQVFRTDLPPLATVG
                     GVPITGGGYGSALAPVLGGSDEYYGLTDRGPNVDGPGGEKVEPLPAFTPSIGKFRLRGG
                     KAELEQTIPLRAADGTPYSGRLSTQADTGEKIVDLNGKPLAPDPNGYDSEGLAVAADGT
                     FWVSDEYGPFVTHFGRDGRAIERLAPGKGLPGELKNRVPNKGMEGLTLTPDGGTLVGIM
                     QSALGQPDLDKKPGHVAPVRIVTYDLRTRAAHEYLYLLDDPKDNDGAVSEITALSATTF
                     LVDERDGQPEPGAYKKLFKIDLAGATDVGPAEKVHDAPYDAAKGGLLVGDDKETIEAYV
                     GAHDTEEATRDLADVDIKPVKKKLHVDVGGLLTRLDPKGGFFGHDKIEGVATTDGGRTV
                     VLSNDSDFGIDGVRGDAPPFALHPKLTPDGKQDDGEFLRIDVTKLPAELRG"
     misc_feature    15465..15480
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.57"
                     /tool="antismash"
     misc_feature    15488..15503
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.44"
                     /tool="antismash"
     gene            15578..16552
                     /locus_tag="HUW46_RS09015"
                     /old_locus_tag="HUW46_01806"
     CDS             15578..16552
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672895.1"
                     /locus_tag="HUW46_RS09015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01806"
                     /product="chitinase"
                     /protein_id="WP_215546863.1"
                     /transl_table=11
                     /translation="MNDKKFSRGRRIIAAALGTAALGVPAVAHADAAPLASSRVSPYID
                     ITAATPSMTSIAKETGQKDFNLAFALADSTGCNPAWGGTVPLTDSRITGDVKGLHDLGG
                     SVTVSTGGAAGPYLETACGSADALYGAYVKALDAVGSNSIDVDVEASIPAGTVNEALLK
                     LQKEKKTKVSYTLRIQGQDYGLDPGSVDILKDAAAKGVAVTVNPMLMDFGYTGDWGDAL
                     ISAANATLKQLKTVWPDKNDADLKGMLSLTPMIGKNDTGSVTDQAAAKKLLDYAKANHV
                     AGIGFWSAGRDNGDCPGGGAVANCSGIEQSKYEFTNIFKAYQG"
     gene            complement(16573..17481)
                     /locus_tag="HUW46_RS09020"
                     /old_locus_tag="HUW46_01807"
     CDS             complement(16573..17481)
                     /GO_process="GO:0043248 - proteasome assembly [Evidence
                     IEA]"
                     /GO_process="GO:0051131 - chaperone-mediated protein
                     complex assembly [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020641021.1"
                     /locus_tag="HUW46_RS09020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01807"
                     /product="PAC2 family protein"
                     /protein_id="WP_215546864.1"
                     /transl_table=11
                     /translation="MLDPEDLYEVDSDVPDLTGAVLLHSLDGFVDAGSAGRLVTEHLLS
                     SLDHRVIARFDVDALIDYRSRRPPMTFSVNRWTEYEAPELVVHLLHDQDGTPFLLLTGP
                     EPDQRWERFVAAVRTLVDRWGVRLTVGFHGIPMGVPHTRPLGVTAHATRGELVKGHQPL
                     FNRVQVPGSASALLELRLGHAGHDAMGFAAHVPHYLAAVYPAAAVSMLDAIGEATGLVL
                     PAADLAEAAEQADADINQKVAESDELSEVVAALERQYDAFTEASSRESLLAESVEHMPT
                     ADELGSAFEQFLAEQSPGQQD"
     gene            complement(17553..18017)
                     /locus_tag="HUW46_RS09025"
                     /old_locus_tag="HUW46_01808"
     CDS             complement(17553..18017)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009081185.1"
                     /locus_tag="HUW46_RS09025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01808"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_215546865.1"
                     /transl_table=11
                     /translation="MSLAEDAEDAVAARAQGWRTLAALHARIEDRLERELRRAHELSVS
                     EYSVLDVLSRQDGFHLRMNQLSTAVVLSQSATTRLVTRLEERGLLQRYLCPTDRRGVYT
                     EVTPAGHELLAAVRPTHDAALGQALGEAVELPELAPLVHALSSLTFGEKG"
     gene            complement(<18111..19190)
                     /locus_tag="HUW46_RS09030"
                     /old_locus_tag="HUW46_01809"
                     /pseudo=""
     CDS             complement(<18111..19190)
                     /NRPS_PKS="Domain: Aminotran_5 (26-335). E-value: 1e-26.
                     Score: 85.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS09030_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009073739.1"
                     /locus_tag="HUW46_RS09030"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01809"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /pseudo=""
                     /sec_met_domain="Aminotran_5 (E-value: 1.3e-19, bitscore:
                     69.5, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVPEAYLAQFTEPAGYLDFGRFGPPSRAVLDTTADLLARTAVAGP
                     STVDELMTQESRAKAAAARLCGTVPEHVVLLPNTSLGLFQAAFSVPGGEVLVAPTEFPA
                     NFYPWVRAEEAGLLRVRPLGAGYVTADGVRAALTGETTAVSVSAVDFRTGYRADLAALR
                     EVVGDRLLVVDGIQGFGVVDEPWEVADVLVVGGQKWLRAGWGTGFAVLSERALDRLRPV
                     LSGWTGVRDAGVFDGEVHPVADGAQAWSISNLSPVTSGAFAAALELVEDAGPAAIGALI
                     ERRVRELEEALSRMGAEIVSATRRRGGILAFALPGVPAKKVGERLAEAGITATARREHV
                     RLTPHASTPATAAELVRAAL"
     aSDomain        complement(18186..19112)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS09030_Aminotran_5.1"
                     /evalue="1.00E-26"
                     /label="HUW46_RS09030_Aminotran_5.1"
                     /locus_tag="HUW46_RS09030"
                     /protein_end="335"
                     /protein_start="26"
                     /score="85.7"
                     /tool="antismash"
                     /translation="RAVLDTTADLLARTAVAGPSTVDELMTQESRAKAAAARLCGTVPE
                     HVVLLPNTSLGLFQAAFSVPGGEVLVAPTEFPANFYPWVRAEEAGLLRVRPLGAGYVTA
                     DGVRAALTGETTAVSVSAVDFRTGYRADLAALREVVGDRLLVVDGIQGFGVVDEPWEVA
                     DVLVVGGQKWLRAGWGTGFAVLSERALDRLRPVLSGWTGVRDAGVFDGEVHPVADGAQA
                     WSISNLSPVTSGAFAAALELVEDAGPAAIGALIERRVRELEEALSRMGAEIVSATRRRG
                     GILAFALPGVPAKKVGERLAEAGITATA"
     gene            complement(19180..20070)
                     /locus_tag="HUW46_RS09035"
                     /old_locus_tag="HUW46_01810"
     CDS             complement(19180..20070)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020673716.1"
                     /locus_tag="HUW46_RS09035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01810"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_254126587.1"
                     /transl_table=11
                     /translation="MTALCLAGCGGAEDTAAPKPSPIPDTNSIVSAVAADPALAAALPP
                     QVSGSGSLRLATNLQSPPNNFYAADGRTPIGYEVDIAKAIAAKLGVRIEHQDEDFSSLI
                     PSLESGRVDLTMAAMNDTKEREARIDFVDYFTSGITIMVRKGNPERVTGPDALCGKAVA
                     AVQGTSNQHFADAQSAKCVKAGMPAVAVEVTESDGRSENELKTGRVSAVLNDLPSASFA
                     ARTVDDGAAFDVVPGQPLNGGPYGIGFAKSNRQLADAVRGALQALIDDGTYGRILAAWG
                     LQQGAVRKAAFNGGP"
     gene            complement(20242..20730)
                     /locus_tag="HUW46_RS09040"
                     /old_locus_tag="HUW46_01811"
     CDS             complement(20242..20730)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016333484.1"
                     /locus_tag="HUW46_RS09040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_01811"
                     /product="hypothetical protein"
                     /protein_id="WP_215546867.1"
                     /transl_table=11
                     /translation="MNTNAYITFLLIGIVLVAIDGQIIYHSGRRYLENSYGAPEAGASM
                     ARLVTVMFHLAVLGILALLSTISLGGDESSMPKVVAKLGILLLVLALAHGITLAVLSRI
                     RDEQVGENLVARKQGLAAERGRGGTTVNPVDPGTDPTRPSVSPSLEHGAPYSAPGEGR"
     misc_feature    complement(20717..20728)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 cgcgggaatc gcactgagcc tcgtcggcgc cgagggcacc gaagcggcgc ggcggctgga
       61 agcggcggga tggtccgaga tgttccggtt ccactgctcg gtcggcgacg cgatcaaaag
      121 cgccgactga gcgggctacc ggggctcgat ttcactccgt gcgcaggcgg tgttcggccc
      181 acgtccgcgc cgacccggcg agtcgtggcc gttgcggctg gggatcggcg tgccgcaggt
      241 acgtccacat cccggccagc gctaccgcga agccggtcag ttccgttcca gagacgtctt
      301 gccacccggg aatccccgcg gcccagcgtt cggcgtccga gggacggtga cctgcgtcga
      361 tgagccggac caccagatga gcggtgtcgg tccaggccgc tccgctacga gcccacgccc
      421 agtcgatgac ccgcgcccgg tcggccacca ggatgttcaa cgagtggaga tcggtgtgca
      481 gcagcgcgtc ccccgcgacg gcttccagac cacgcgcctc ccattcgacc agcaggtcca
      541 actgctcacg gctccagttg tccagttccg caggcggatc atggcgcagg cgccgccatc
      601 cggccaacca cgccatcttg tccgcgaggc tggggacccc ggacgggcac tgcgccaatt
      661 cgcgcgccag cgtggtcatc gcttcggtga ccagcggaag atccggtgaa cccggtgaga
      721 ggtcggcatg gcacccggcg acgtgctcga agcccagcag cagccagccg tccgcctcgg
      781 cctgccacag cagccgcggc gcaacctcgt gcggcagcca cttgttgatc atggactcgt
      841 gccggtgcat cgcgccacgc ttgccgtggg cgtcggtgat gcccttgcag aacacgggtc
      901 cgcggtcggt gtacacggtg gcggagaagt cggagttccg ccccgccgaa ggttcttccg
      961 cgcgaaggac ccgcccgcac tcgcgttcga tcacggctcg cacgagcgcg ggcaggcctt
     1021 cccaggtggt gcggggcatc gagttcctta ccggcacgcg ggtggcggat cgtcggagca
     1081 gccgttctgg cactgcgaac agtccacatt gcactgactg cctaccgcgg gccacagcgc
     1141 ggggtcgacg gcgagcccgg atgatttgat cgcggccaca gtacggctca gagtttcacg
     1201 ggcagcctca ccgcgggcag ccgggtcgtt ctcatccgtg ggaacgtggt gcaggaagcg
     1261 accggcgatc cgttcgcaaa acgcggcgta gtccttggtg tgcaacagaa aagtgtgcca
     1321 accgacgtcc accagttcac tcggcgcgag cggcgagccg gtgttgacgg cacaggccac
     1381 caggaacgcg agcgtttgct cggtgatgcg ctcggccagg tcccgatcca gtttctcctc
     1441 gccgacgatc cggcgcgcga gccggtcgaa cagttcgggt gagacgagcg agcgaccggt
     1501 ggcccggccg gtcaggactg aggtcatggg aactccttcg gttggcgatc gaaccgcgcc
     1561 gatcggcgct gggtccgaga acaccgcaac cgcggggcgt gtggctaggc tgagaaccga
     1621 ctcacggtag gttcacgcac actcacggtc ccggctcagc tggaggtggc aacggtggca
     1681 gatccagccg gtgacgtgaa cgctttcgcc gtcgaacttg agcgatggcg cgatgtacgc
     1741 ggacattccc gcgcggccct ggccaaggcc atgggttacg accgctcgta cgtctccaaa
     1801 gtgctttccg gtgcggagcg accttcggaa gcgttcgccg tgcacgccga gaccgcactg
     1861 cgcgcaggtg gtgccctgcg agccgcgttc cgcgagtacg aagcccgtcg cccggccagg
     1921 ccacggcctc aggctgcccc ggcggtcgcg gatccaccgg ccgggacggg cggcatcgtc
     1981 gtcgaccacg acgacgcgat cctgcgctac gacgaaggcg tctaccggct cacgcagagg
     2041 cggcgcttgg tcaacgaagg tggcgagccg atcagccgct acctgatccg catctcggtc
     2101 gatcggtatc ccggcgaccc ggaacggtca aaccagctgt acagcgaaaa cccgctgacc
     2161 tgggacgaga tcgagctgcg tgcctggcac ggccgtggac ggtccactgc gatgacctgg
     2221 acgccccacc acgaccgcga cgcgttcaag gaagtgtggc tgctcttcga gggcgagcag
     2281 ggccattttc ccttgtatcc cggggaagcg tgctggatcg agtacgaata caccgtgcgg
     2341 gacgagcact ggggaaactg gttccagcgc gccgtccgcc tccccacccg cactctgtcg
     2401 gtgtgcctcg acttcccagc ggacttggca gcgtcggtgt ggggcctgca cacctcgatg
     2461 acctcgcagg ccatgccgtt cgccaccgcc atcaaacgcg atgacgacgg cgaccgtcac
     2521 gtcttctcct ggtcgtgcga agacccaccg ctgcatgccc gttaccggct cgaatggggt
     2581 ttccgtagtg acaccgccgc cacggggcca gcgcccaccg cggtgatggc ctcgctcggg
     2641 atcgtgcagg actccgatcc cgcgttgcgt gaaccggccc gcaggttcgc gcttccttca
     2701 gaggccgaag acgcccaccg agtcgtcgcg gagttgaagg cagcagccga gcgcgtcgcg
     2761 cgggcgcaca ctttcggcaa gggtatgggg atcgccgcac cgcagatcgg ggtcaaccga
     2821 gcggccgcga tcgtgcgcac cccggacggt gaggtgatca cgctgttcaa ccccaggatc
     2881 atcgaaaccg cgggcgagat cgacgaacag tacgaagggt gcctctcgtt cttcgacgtc
     2941 cgcggtcaag tcccgcgggc gcacacgatc caggtcgagc acaccagcgc cgacggccgg
     3001 acgaagataa cggccttcga caaaggcgtt gcccgcctcg tcgcgcacga agtggaccac
     3061 ctgcacggga cgctgtacac cgaccggatg cgcgaaggcg tcagcccgat cccggtcgag
     3121 cagtaccggg gcacggggtc gcgctggaaa tactgaggtt gctcctcccg gcgacgagta
     3181 ccgggaatcg gggtttcacg gcaggcggcg gagggtttcg ttcgggcgtt ccccgtagcg
     3241 gtcccggtag ccgacggaga accggccgag gtgcgcgaaa ccccatcgcc cggccacttc
     3301 ggtgacggtg accgcgccgg gttcggcggc gagcaggtcc gcgtgcgccc tgccgagccg
     3361 gacctcgcgc aggtaagcca tcggcgggcg cccgatcgcg cggcggaacc cgtcgtgcag
     3421 cgagcggacg ctcaccgcga ccgcggccgc cagctccgcc ggtgaccacg ggaattccgg
     3481 ggtttcccgc agcagttcga tcgcgtggcg caccacgcgc ggtgccgcct cgtgcgcttt
     3541 ctcggtcagt tccgcggaat aggtgtgcgg ttgggcgcgg agcaccgcgt cgatcacctg
     3601 gtcccgcagg gtcgccgcgg cgagcggctg gcgcagcacg ccgtccggct tcgccgtttc
     3661 ccggtcgagg agccgcagca ggtcgagcag ctcgcgcgcg gcgccggagc cgaggtccat
     3721 cgcgaccgcg aaatcgggtg cgccggtgac cggccggtcg aggtgcttcg cgagccgctc
     3781 gcgcagggtt tccgccggga tcatcaggca cagctgcgcg cagtccgccc gccagcgcag
     3841 atcggctggc gcgccggggg tgaacaccgc ggcgcgccgc gggctgcccc gcaccgggcc
     3901 gcggttgccc gaacgcgatt cgacggcacc ggacagcggc acgttcacgt ggtagctcgc
     3961 gcagtccccg gtgaccacgc gcacgtcgct gccgaagcgc acgtacccga ccgtcacccc
     4021 ggcgagccgc accgcgttca accgcatgtc cagcggggtc gccggatcga gcaggtcgat
     4081 ccggttgggc aggtagaccc gttcgatcgc ctcgttcgcc accgccacgt ccgcggtctc
     4141 ggcgacccgg tggacggcga acgcgggctc ggcaccttgc gcgcgcaaag ctcacctcct
     4201 ggccgctgtt caccgtacgg cgcccgcggc caccggctca actgtccgaa gtggacttat
     4261 cacggggtgg ggatcatgaa gctcagcaca ctcgcctgca gcagcgcgag aacgccgacc
     4321 acgccggtga gcacgagcga ccacaggaag gtctgccgca gcagggtgcc ctccttcccg
     4381 ctctgcccga tcgcggtggc gccgatggac aggttctgcg gcgagatcat cttgcccatc
     4441 acgccgccgg aggtgttcgt cgcaccggcg agcgtcgggt cgaggtgcag ctgctgcgcc
     4501 gaaatcacct gcatcggccc gaagatgctg ttcgtcgacg cgtcggaccc ggtcaggaac
     4561 accccgagcc agccgatgta ggcggagaac agcgggaaca gcgcgccggt cgccgcgagc
     4621 gcgagcccga gcgtctgcgt cgcgcccgaa tagttcatca cgaacgcgat ggccaggatc
     4681 atgaagatcg tcgcgagcgc ccaccgcatc tggtgcacgg tccgccggta cgtcctggcc
     4741 agcaggcccg gtttcgcgcc catcgcgaac ccggcgatca gcgcggcggc gagcgcgacc
     4801 gtgccgggcg agaacaggaa gtcgacggtg aacgacgccg cgtacggggt gtccttcggc
     4861 gtgatcggcg cgtgctgcac gaccgccttg tccagccccg gccacccgaa cacccagtcc
     4921 gccttgtgca gcagcttcgt caggtcgagc cacggcggca ggtccttgaa gatcgtgccg
     4981 atccgcgagg cgaagatcgc cgcgatcagg atgacgtagg gcagccacgc gtggaacggt
     5041 cccgccttcg gcgcaccggt cgccgcggcc accggctcct cgccgtcgaa gcgccacacg
     5101 gttttcggct gccagaaccg ggtgaggatc cacagcgacg ccatcgcgcc gagcgcggcc
     5161 accacgtcca ccaggctcgg gctgacgtag ttcgacacca cgaactgcag ggccgcgaag
     5221 gtgatcccgg ccgtcgcgac cgcggggagc acctccagca tgcgcttcca gcccgcgagc
     5281 accaccacca ggaacgccgg gatgatcacc gcgagccacg gcacctgcct gcccaccatc
     5341 gaggagaaca gatccgttgc ctggtccggt ttcaggtgca cgatcggcgc ggtgagcctg
     5401 cccagcacga tcagcgggtt gccgagcccg ccgaaggcca ccggtgcggt gttcgccagc
     5461 agcgccagca ccacggcctt caccggcggg aacccgagcg cggccatcat cgccgcggtg
     5521 atcgcgatcg gcgagccacc cccggcgacg ccttcgagca gcgcgccgaa gccgaacgcg
     5581 atgagcagcg cctggagcct gcggtcctcg ctgaacccgg cgagcacggt cttgatgctg
     5641 tcgaaccggc cggtggccac cgtgacgttg tggaagtaca ccgcgtggaa ggcgatccag
     5701 gcgaccgacc acaccccgaa caccacgccc atcgccgccg agtccagtgc cagccccacc
     5761 ggcatgcggt acagcgccag cgcgaccgcg agcgcggtga gcagggccag cgccgcggag
     5821 aggtgggcgg accggcgcag cacgccgagc gagaccagca gcacgacgat cggcagcgcc
     5881 gccagcaacg cggagggcca cagcccgccc gccggctggt agtcctgcac ccagcccacg
     5941 ctcaggctcc ttgcgccggt acgtgaccga ggcggcggga cagcgcggcc gcggtggcga
     6001 cgaccagccc ggcgagttcg ccgcgacgcg gcagcacccg ttccgccggt cccgccacgc
     6061 tcatcgcggc caccggcgcc ccgctgcgat cccggatcgg ggccgccacg cagccgaccc
     6121 ccggctcgtt ctcgacgtcg tcgagcgccc agccctggcg gcgcgcggtc accagctcgt
     6181 cgagcagacg aggcagctcg acgatggtgt tcccggtgag ccggtccagt ttcatccgcc
     6241 gcaaccgctc cactctgtcc acttcggaca aagcggagag gtaggccttg ccgagcgagg
     6301 tcgcgtactg cgggcggcgc gcgccgaggc ggcacttgag cgtcaccgcg cccgcgctct
     6361 gctcggtcgc cacgtagacc atcgcgttgc cgtccggaac cgcgagatag gtggtctccc
     6421 ccgacttttc cgcgagcgcg gcgaggaacc ggggtgccgc gcggtgcagg tcgctcgacg
     6481 acatcgcgcg cacgccgagt tcgacgagcc tggtgccgag ccggacgcgg ccggtcacgt
     6541 gatcggcttc gaggtagtcg agctgcttga gggtgttgac gatgcggtac accgcgctcc
     6601 tcgacaaccc cagctgcgtg gcgatcgcgt tcgtcgaaat ctcctgcttg agcccgacgt
     6661 gccggagcac cgccagcccg cgctccagag tgccgctgcg ttcgaacgtg ccgtgctcac
     6721 aatccacgtc gacctcccag cccgcccggt gtgccgttcg ccgggacacc ggcccgatga
     6781 gcggaaggaa gttaacacgt ccgatgtttg tcagggaaga gcgaaaagtg aactcggttc
     6841 attaccccga aaggtcatcg ccgacgaaga tagtcctttc ctgccagcgg atattcacat
     6901 ccatgaaaat ccaaagaggt ccagaccatt gctcgctctc cgatgacaca tcggagggga
     6961 acgtaagcga gggcggcacc ccgtgtccgg gatgccgccc tcgctctaca aaggactcgg
     7021 tgggctcagc gcggtgcggc ggcggtgtcg agcttggcgt ggaccgcgaa cagcgacgcg
     7081 agcccggtgg cttcgaacac gcgccagacg atgtgctcgg tgatgaccac gctcacctcg
     7141 accccgcgcc cgcgaacctc gacgagcgcc tgcagcccgg cgcaggacag gaatccgacg
     7201 cgcgagaggt ccaggacgag ttcgctcgtc gcgacgcggt ccaggtgtgc gcgcaacgcg
     7261 tccacggtca tcgcgtcgac ctcgccgacc acggtcagca ccgtccggtc gtcgtactga
     7321 ctctcggtga ccgataggcc gtggccgtcc ggcaaccggg gcaggggtat ttccatggtg
     7381 cgctcctctc gatgaccgcc ggattcgaaa acccgcactg tgtggagatg cgcgaaacca
     7441 ctggcggcca tcaacgtccg ctcgacaatc gctgaccgga gcacgtgtct gaacaacagc
     7501 cagtgacttc caaagtacgc gctcgccggg acaggtcaac ccctcggccg ggtcaacgcg
     7561 gtaagcggcg ccacagcgct cgcgggagca agcgcagcac cgcgaacacc ggcctcagca
     7621 cgccgggtac ccacacctcg ccgcacccgc ggcgcagcgc gcccagcgtc gccttcgcca
     7681 cttgtgcggg cgtgctcgaa aacggcgcgg gcgacatgcc ctcggtcatc cgccccacca
     7741 cgaaacccgg gcggacgagc agcaaccgga ccccgctgcc cgcgagcgcg tcggcgagcc
     7801 cgctggcgaa cccgtcgagc cccgccttcg ccgaaccgta gacgtagttc gcccgccgca
     7861 cccgcacgcc ggcgaccgag gagaacacca ccacggtccc gctcgcctgc ttccggagca
     7921 ggttcacggc gtgggtcagc acgctcacgt gcgcgacgta gtcggtgtgc accacggcga
     7981 ccgcgtgccc ggcgtcgttt tccgcacgct gctggtcgcc gaggatgccg aacgcggtca
     8041 cgatcacgtc cagcgggccg aaccgcgtgg cgacgtcctc gagcagcggc aggtggctcg
     8101 ccaggtcgtc ggcgtcgaac tcgacgcgtt tgacggcacc ggcgcccgcc gcgcgcaagg
     8161 cgtcctcctg cgcgtcgagg tcgtggctcc gccgcgcggc gagcacgatc gtgcgccctt
     8221 cggcggcgag gccgcgcgcg acctcgagcc cgatctcact gcgtccgccc agcaccagca
     8281 ccgttgaagt cacggagccg agtgtgccgt acgcgttcgt gactaggctg cgcgccgtga
     8341 cctacgttgc cgcgaacagc cgatacgaca cgatgcccta ccgccgctgc ggccgcagcg
     8401 ggctgaagct gccgcccatt tcgctggggc tgtggcacaa cttcggccac gacaagccgt
     8461 tcgagaccca gcgcgcgatc tgccgccgcg ccttcgacct cggcatcacg cacttcgacc
     8521 tggccaacaa ctacggcccg ccgtacggct cggccgagga gaacttcggg cggctgctcg
     8581 ccggggactt cgcgccctac cgcgacgaac tggtcatctc gtccaaggcg ggctacgaca
     8641 tgtggccggg cccgtacggc gactggggct cgcggaagta cctgctcgcc tcgctcgacc
     8701 agtcgctgaa gcggatgggg ctcgactacg tcgacatctt ctactcgcac cgcttcgacc
     8761 cggagacgcc gctcgaagag accatgggcg cgctggacac cgccgtgcgc tccgggcgcg
     8821 cgctgtacgc gggcatctcc tcgtactcct cggaaaagac cgccgaagcc gtccggatcc
     8881 tgcgcgacct cggcacgccg ctgctcatcc accagccctc gtactcgatg ctcaaccgct
     8941 ggaccgaagc cgacgacctg ctcggcacgc tcgacgaagc gggtgccggg tgcatcgcgt
     9001 tctccccgct cgcccagggc atgctgacca gccggtacct cgacggagtg ccgccggact
     9061 cgcgcgcggc ggcgggaaag tcgctcaacc ccggcacgct caccgaggaa acgctcgcga
     9121 aagtgcgcgc cctcaacgaa atcgcgcggc ggcgggggca gacgctcgcc cagctcgcgc
     9181 tcgcctgggg cctgcgcgac ccgcgcatga cctcggtgct gatcggcgcg agcagcgtcg
     9241 gtcagctcga agacaacgtc gccgcgctcg gcaacctgga gttcaccgac gacgagctcg
     9301 ccgagatcga ccgccacgcc acggacgcga acatcaacct ctggcagcgg tccagcgcgc
     9361 actgaggcgg ccttcacggc gaatatcctg ggccttcacc cgatcgggtg aggcttgcgg
     9421 tacaaaggtg ccctccggtg tgcgaccgaa gggtttcccg tgaacgacga agtgtcggtg
     9481 tccgcgctgc tcgcgcgcga aggctggggt gagcacctgc cgccccggcc acgctcgcgc
     9541 tggcgcgtga tggccgtgat ggccgccgtc gtcacgggct gcggtgccgc ggccgtcgcc
     9601 gtgaacgtct cctcgccgtc cgacgaccgc gccgacgatc cgctcatcgt gcaaccgccg
     9661 ccgcccacca gcggcaccgg cgaagaaacc actgccgtcc cgacggctcc gccgagccgc
     9721 cggggcggca gtggcggcgg cgagccgtcc acggcggcgt ccacttcgga atcaccgagc
     9781 cgaaccggcc gcacctcggc gaaacccacc accgccgccc atcccagcac cgaggacccc
     9841 gcccccaccg ggcatcccga gccgagcagg cccgcaccgc ccaccaccgg tggcggcggc
     9901 accagcaccc gcccggcccc gccgccacca ccgaccacct cgaccgcacc cccgtgcacc
     9961 atgtggccgg aatggctgtg gtgctgagaa aacgtcgggg tcacccggtc cgctgcacca
    10021 tcaggtgcgc gacggcggtc agttcgacct cggccttcgg gtccggatcg caggcgcgga
    10081 gttcggcgag cgcgtcggcc agcaacgcgc tcgcctggtc gcggcaccac gcccggccgc
    10141 ccgcggcgtc gacgaggcgc gcggcccgca ccagatcgtc caccgccagc ggatccggcc
    10201 ggtggtagag ctgcccgaac tcccggcccg cgtcggtgtc cgaagtcaac gcggccacca
    10261 cgggcaggga cttcttgcgg ctgcgcagat ccgagtagac ggacttcccg gtcgcggccg
    10321 ggtcgcccca gatgccgagc agatcgtcga cgaactggaa cgcgaggccg agccggtcgc
    10381 cgaacgagcg gaggtgccct gctccggccg cgacgctccc tgccgccgcg gcacccagtg
    10441 cgcacgcgca cccgagcagg gcaccggtct tccgctccgc catccgcacg cattcggcga
    10501 ggccgacgtc ccgccgccgt tcgaacgaca ggtccgcgct ctgcccttcg acgagttcga
    10561 gcaccgccgc gctcagcatc cgcgccgact ccgcggccac cgcgctgccg gtcgacgcga
    10621 gcacgtcacc cgcgagcgtc aacagcgcgt cgccggccag aatcgccgcc ggagtcccga
    10681 aaaccgacca cacggtcggg cggtgccgcc tcgtcgtgtc cccgtccatc acgtcgtcgt
    10741 gcagcaggga gaagttgtgc gccagctcca ccgccaccgc ggcgggcacg gcgccggcgg
    10801 gatcgccgcc cgcggcctgc gcgctcagca gcgtcagcgc gggccggatc gcctttcccg
    10861 ccgactcctt cgcgggtttg ccccgctcgt cgagccagcc gaagtggtag cccgcgatca
    10921 gccgcatcga ccccggcatc gagtcgaccg cctccctcag tgccgggtcg agcaggcccc
    10981 tgctccactc gaggagcgcg cggaccgggc gtccggtggc cacgggtagc ccggtgagat
    11041 ccgaagtgac catgccaacc tgccttcccc gagtggattc gacgtcgtcc tcactggact
    11101 gtgtgctggc gtgcgcccct tcgcagggtg acccggcgcg gttgcgaagg ggcgcaccgg
    11161 agggagcgtc ccgcgcccgg acgtgtgtcg gccgcacgtc cgtgagccgc tccgtggtcg
    11221 tagaaataga cgcgacgaaa tgggttcaca aaacgagatg cctgcggaat tggaaaacga
    11281 ttgacgtcgt tttcgccgtg cattttcgaa cgccgatgga accgacgcta gcaccgcccg
    11341 cggcaacccg tacagtcacc cgaaagtgcg gtcgcggcgc cgattaatcc aattttgctc
    11401 cgtaccgatt catcagatcc agctctcgac tgcgacccac agtagagcag acgctgcgta
    11461 gccgtctcac cggccacccg aatgcgcggc agctcgcaca tccgaggccg tttcgcctgc
    11521 gcacgacctc ggagcgcata tcgaaacgcc gtcacagccg atgatcttgc tcgtcagggt
    11581 cacaaagcgg taggtcggcg cgcggcatgg gcggaccgtc catcccggat ccgactacta
    11641 cggacagtga gcgcagtggt cgctcaaatg gcgcaccgcg ggtccacttt gtactctttt
    11701 cctcccgttc tcctgatgcc aataagccga cgactcggcc gcgccggtga cgtttcgcac
    11761 cgactgggaa tcacccggat gaattgtcga atcgtgactt gtcggcaccg gccgcggctg
    11821 actagcttcg atcactatcg gcgggcccgc tgccgggtaa tcggcacggg cggatatttc
    11881 ggcgaccgcg cacgaccggc gaaaggccac gatgagcatc tatctgagcg gtctcctctg
    11941 ggtggtgggc gcggccgccg ctggcgcggg cagcgcctat ctggtgaggc ggttcgggct
    12001 ctccgaaggc agacctgaca acaacgacgc ggcgggccag gtgttcacga tcgtgagcgg
    12061 cctgcaggcg gtgatcgtcg ctttcgtgct catttcgcag ttcgacgccg tggacgcggc
    12121 gcgcgacggc gccttcaagg aagcgaacgc cgcggtcgcc gcgtcgtggg cggccgacgc
    12181 gctgcccgag ccgacgcgcg gcgaagtccg cgagcaggcc gccgcctacg cgcgcacggt
    12241 ccaagacgtc gagtggccgc agatgcgcgc gggccacacc gtggagagcg acggctgggc
    12301 ccagctcgcc aggctccgcg acaccgtggc ggacgcgcag accgcggacg gggacgactg
    12361 ggccaccgac cgcaagaccg aggccgcgaa ccaactctgg gacgtgtacc aggcgaggca
    12421 ggagcggatc accggcgccg tgcagaacgg cctcggcgcg gtgctgtggt tcgtgttgat
    12481 cctcggcagt gtggtgacgg ttctgatgcc gaacctgttc ggcggcacca agccgcgcac
    12541 gcacatcatc atcgtgtcca ccctcgccgg cacgatcacg gtgctgctgt tcgccatcta
    12601 ccagttgcag aacccctacg cgggcgggac gaagatcgaa ccggacgcct tccggtgggc
    12661 actcgaccgg ttgagctgac ccgtgccgtc cgcgcgccgc gccttcccgc tcgccgcctc
    12721 ggcactgctg ctcggggcgc tcgcgttcct gcccaccgcg gctggcgcgc gcgagcccga
    12781 aacctgcacc gcgatcgaag tgcggtcccg cctgccgacc gacctctcct cggcctaccg
    12841 ggtcgagctg ccctcgggcg cggtcaccgc gctgggccgg ctcgactacc gcgtcaacgc
    12901 gctcggctac gcgaaggcgc agaacctcgc ctacggcctc gccgatttcg cgagccggtg
    12961 gccgacgccc ggcgcgccgc gggtggtcac gatcgcccgt gacggcaccg tgcgcgaccg
    13021 cggtccgatc cgccgcggcc cgcatccggg gctcggcccc gccctggtca gcgcgacggc
    13081 cggggcgatc gtcggaaacc ggtggtacgt caagagaatc ggcacactgt acacagtgga
    13141 catcgacccg gcgagcgcga cctatctgag cgtggtgcac gcgacgaggc tgcggccgct
    13201 cggactcgcc gccaaggtcg acgacttcga cctcgacccg gcgagcgggc tgctggtcgg
    13261 cgtcgcggcg gacgcccacg aaccgggcgc gctggtgagc ctggacccgg tgagcggtgc
    13321 cgtgcggcgg cttccggggc cgaggctgcc cgcgagttcg gcctacggcg ccgtcgtcgc
    13381 cttgggcggc gggacgcttt cggtgctggc gaacgacgtg cgcggccgcg gccgccgcta
    13441 cctggtgccg ccgaacggca ccccggtgga aatcgacgcg ggccccgcac tgtccagttc
    13501 ggacggtgcg ggctgcttca ccgcgccacc accgccgacg acaccgccca ccacaccacc
    13561 caccacacca ccgacgacgc cgcccacgac gccgccgacc acaacaccga cgactccccc
    13621 gaccacgcct cccagcacac cgcccagttc gccgcccgca cccccgccac caccaccgaa
    13681 ggccactccc ccgccgtcac cggttccggt tccacccccc gcatcggagc cggaaccggt
    13741 gacccccgcc ccaccgccac cgccgccgtt gccgaccgcg gaaccggtcg ccccggccaa
    13801 accggcgcca ccgtcaccgc ggcccacgac gaagaagccg gcgcaggcgc gcccgacgcc
    13861 gagcaagtcc gccgacgcgg gcccgacccg gctcgagcgc accaaggaaa agcgccgctg
    13921 gggcgtcgcg gtgctgctga tgacgatcgg cgcggccgcg gtgacccgta gcgccgcacg
    13981 gcaccggtcg cgctgatccg gtcagccgcg cagctcggcc gggagcttcg tgacgtcgat
    14041 gcgcaggaac tcgccgtcgt cctgcttgcc gtccggggtc agcttcgggt gcagcgcgaa
    14101 cggcggggcg tcgcctctga cgccgtcgat accgaagtcg ctgtcgttgc tgagcacgac
    14161 ggtgcgcccg ccgtcggtgg tcgcgacacc ctcgatcttg tcgtgcccga agaacccgcc
    14221 cttcgggtcg agccgggtga gcagcccgcc gacgtcgacg tgcagcttct tcttcaccgg
    14281 cttgatgtcc acgtcggcga gatcgcgggt cgcctcttcg gtgtcgtgcg cgccgacgta
    14341 ggcctcgatg gtttccttgt cgtcgccgac aagcagcccg cccttcgccg cgtcgtacgg
    14401 cgcgtcgtgc accttctccg cggggccgac gtcggtggca ccggcgaggt cgatcttgaa
    14461 cagcttcttg tacgcgccgg gttccggttg gccgtcgcgc tcgtcgacga ggaacgtggt
    14521 ggcgctcagc gcggtgatct cgctgaccgc gccgtcgttg tccttgggat cgtcgagcag
    14581 gtacaggtat tcgtgggcgg cgcgcgtgcg gaggtcgtag gtgacgatcc gcaccggcgc
    14641 gacgtgaccc ggtttcttgt cgaggtcggg ctggccgagc gcggactgca tgatgccgac
    14701 gagcgtgccg ccgtccgggg tgagcgtgag cccttccatc cccttgttcg gcacccggtt
    14761 cttcagctcg ccgggcaggc ccttgccggg tgccagccgc tcgatcgcgc ggccgtcgcg
    14821 gccgaagtgc gtgacgaacg ggccatactc gtcggagacc cagaacgtgc cgtcggccgc
    14881 gaccgcgagc ccttcggagt catagccgtt cgggtcgggt gccagcggtt tcccgttgag
    14941 gtcgacgatc ttctcgccgg tgtcggcctg ggtggaaagc cgcccggagt acggggtccc
    15001 gtcggcggcc cgcagcggga tcgtctgctc cagctccgcc tttccgccgc ggagccggaa
    15061 cttcccgatc gacggcgtga acgcgggcag cggttcgacc ttctcgccgc cggggccgtc
    15121 gacgttcggg ccgcgatcgg tgaggccgta gtactcgtcg ctgccgccca gtaccggcgc
    15181 gagcgccgaa ccgtagccgc cgccggtgat gggcacgccg ccgacggtcg ccagcggcgg
    15241 caggtccgtg cggaacacct gcaccgcgtc gcgaagccgg tcaccgtgcg ccgaggcagt
    15301 ccccgccgcg ctcagggaca ccaccaggcc cgccgcgatc gccagtcttc tcatccgctg
    15361 ctcctcctcg tcgtttcccc ctcggggcag tgtcgtcaac gcgggtgtcg ggcggaaggc
    15421 cgctggatga acaccgcgcg cgggcactgg acaacgaccg gacagatggt ctagacccct
    15481 tgaccttctt ggtttagacc acctacggtc gcgtgaccgc cggtacggag acggtcaccg
    15541 gcggcaccgg tcgggggtca cggaacggac gaaacgtatg aacgacaaga agttctcgcg
    15601 aggaaggcgg atcatcgcgg cggcgctggg cacggccgca ctgggtgtgc ccgcggtcgc
    15661 gcacgccgac gcggcgccgc tcgcgagcag cagagtctcg ccctacatcg acatcacggc
    15721 ggccaccccg tcgatgacgt cgatcgccaa ggaaaccggg cagaaggact tcaacctcgc
    15781 cttcgcgctc gccgacagca ccggctgcaa ccccgcgtgg ggcggcacgg tcccgctcac
    15841 cgattcccgc atcaccggtg acgtcaaggg actgcacgac ctcggcggtt cggtcacggt
    15901 gtcgaccggc ggggcggcgg ggccctacct ggaaaccgcg tgcggctcgg cggacgcgct
    15961 gtacggcgcc tacgtcaagg cgctggacgc ggtgggcagc aacagcatcg acgtcgacgt
    16021 ggaagccagc atcccggctg gcacggtcaa cgaggcgctg ctcaagctgc agaaggaaaa
    16081 gaagaccaag gtcagctaca cgctgcggat ccaggggcag gactacgggc tcgaccccgg
    16141 ctcggtggac atcctgaagg acgcggccgc caagggcgtc gcggtcacgg tcaacccgat
    16201 gctgatggac ttcggctaca ccggtgactg gggcgacgcg ctgatctcgg ccgccaacgc
    16261 cacgctgaag cagctgaaga ccgtctggcc ggacaagaac gacgccgatc tgaaggggat
    16321 gctctcgctc accccgatga tcgggaagaa cgacaccggc tcggtcaccg accaggccgc
    16381 ggcgaagaag ctgctcgact acgcgaaggc caaccacgtc gcgggaatcg gcttctggtc
    16441 cgcgggcagg gacaacggcg actgccccgg cggcggcgcg gtcgcgaact gcagcgggat
    16501 cgagcagtcg aagtacgagt tcacgaacat cttcaaggcc tatcagggct gaggggagcg
    16561 cgcgggcccc ggtcagtcct gctgaccggg gctctgctcc gccaggaact gctcgaacgc
    16621 cgaacccagc tcgtccgcgg tcggcatgtg ctcgaccgat tcggccagca ggctttcccg
    16681 gctcgacgcc tcggtgaacg cgtcgtactg gcgctcgagc gccgcgacca cttcgctcag
    16741 ctcgtcggac tcggcgacct tctggttgat gtcggcgtcc gcctgctcgg cggcctccgc
    16801 caggtcagcg gcgggcagca cgagcccggt cgcctcgccg atcgcgtcca gcatgctgac
    16861 cgcggcggcg gggtacacgg ccgcgaggta gtgcgggacg tgcgcggcga agcccatcgc
    16921 gtcgtgcccg gcgtggccga gccgcagctc cagcagcgcc gaggcactgc cgggcacctg
    16981 cacgcggttg aacagcggct ggtgaccctt gaccagctcg ccccgggtgg cgtgcgcggt
    17041 gacgccgagc ggcctggtgt gcggcacgcc catcgggatg ccgtggaagc cgaccgtgag
    17101 ccgcacgccc caccggtcga cgagcgtgcg caccgcggcc acgaaccgct cccagcgctg
    17161 atccggctcc gggccggtga gcagcaggaa cggcgtgccg tcctggtcgt gcagcaggtg
    17221 caccaccagc tccggtgcct cgtactcggt ccaccggttg accgagaagg tcatcggcgg
    17281 gcgccgcgag cggtagtcga tcagcgcgtc cacgtcgaac cgggcgatca cccggtggtc
    17341 gagcgagctc aacaggtgtt cggtgacgag acggccggcg gagcccgcgt cgacgaaccc
    17401 gtccagcgag tggagcagga cggcgcccgt cagatcggga acgtccgaat ccacctcgta
    17461 gagatcctcg gggtccagca cactgcctcc agatttcgac tgcccgtacc ttaggtcaac
    17521 gcgcgaaggc gccggaggaa ttccgccgaa ggtcagccct tttcaccgaa ggtcagcgac
    17581 gacagcgcgt gcacgagcgg cgccagctcg gggagttcga ccgcttcgcc gagcgcctgc
    17641 cccagcgcgg cgtcgtgggt cgggcgcacg gcggcgagca gctcgtgccc ggcgggggta
    17701 acctcggtgt agacgccgcg gcggtcggtc gggcacaggt agcgctgcag cagcccgcgc
    17761 tcttcgagcc gcgtgaccag gcgcgtggtc gccgactggc tcagcaccac ggccgtggag
    17821 agctggttca tccgcaggtg gaaaccgtcc tgccgggaca gcacgtccag cacgctgtac
    17881 tcgctcacgg acagctcgtg cgcgcggcgg agctcgcgtt cgagccggtc ttcgatccgg
    17941 gcgtgcaggg ccgcgagcgt gcgccagccc tgcgcgcgcg ccgcgacagc gtcttcggcg
    18001 tcttcggcca gtgacacgat tcaccttctc ccacccggat agcaggcacc cgcaactatt
    18061 gagcgcgccg gtagttgacg gcgccgcaca cagcgtactc cggctcaggc cagcgcggcg
    18121 cgcaccagct cggcggccgt ggccggggtc gacgcgtgcg gtgtcagccg gacgtgctcc
    18181 cggcgcgcgg tcgcggtgat cccggcttcg gccagccgct cgccgacctt cttcgcgggc
    18241 acgccgggaa gcgcgaaggc gaggatcccg ccacggcgcc gcgtcgcgga cacgatttcc
    18301 gcgcccatgc gcgaaagcgc ctcctccagc tcgcgcaccc gccgctcgat cagcgcgccg
    18361 atcgccgcgg gcccggcgtc ctcgacgagt tcgagcgccg cggcgaacgc gccggaggtc
    18421 accgggctca ggttgctgat cgaccacgcc tgcgcgccgt cggccaccgg gtggacctcg
    18481 ccgtcgaaca cgcccgcgtc ccgcacgccc gtccagcccg acagcaccgg ccgcaggcgg
    18541 tcgagcgcgc gctcggacag caccgcgaac ccggtgcccc agcccgcgcg cagccacttc
    18601 tgcccgccga ccaccagcac gtccgccacc tcccacggct cgtcgacgac gccgaagccc
    18661 tggatgccgt cgaccaccag caggcggtcg ccgacgacct cccgcagcgc cgcgagatcg
    18721 gcccggtacc cggtgcggaa gtccaccgcg ctcaccgaaa ccgcggtcgt ttcgccggtc
    18781 agcgccgcgc gcacgccgtc cgccgtcacg tacccggcgc cgagcgggcg cacgcgcagc
    18841 aaccccgcct cctccgcgcg cacccagggg tagaagttgg cggggaactc cgtcggcgcg
    18901 acgagcactt cgccgcccgg aacgctgaac gcggcctgga acaacccgag gctggtgttg
    18961 gggagcagca cgacgtgctc gggaaccgtg ccgcacaacc gcgcggcggc cgccttcgcg
    19021 cgggactcct gcgtcatcag ttcgtccaca gtggacggac cggcgacggc ggtgcgcgcg
    19081 agcaggtccg cggtggtgtc gagcaccgcg cgcgagggcg ggccgaaccg gccgaagtcg
    19141 agatatcccg cgggctcggt gaactgggcg aggtaggcct cagggaccac cgttgaacgc
    19201 cgccttccgc accgcgccct gctgcagccc ccacgcggcg aggatccggc cgtaggtgcc
    19261 gtcgtcgatc agcgcctgca gcgcgccccg caccgcgtcc gcgagctggc ggttcgactt
    19321 cgcgaacccg atgccgtacg gcccgccgtt gagcggctgg cccggcacca cgtcgaaggc
    19381 cgcgccgtcg tcgaccgtcc gcgccgcgaa gctcgcgctc ggcaagtcgt tgagcaccgc
    19441 ggaaacccgt cccgtcttca gctcgttttc gctgcgtccg tcgctttcgg tcacttcgac
    19501 cgcgaccgcg ggcatcccgg ccttcacgca cttcgcgctc tgcgcgtcgg cgaagtgctg
    19561 gttgctggtg ccctgcacgg ccgccaccgc cttgccgcac aacgcgtccg gcccggtgac
    19621 ccgctccggg ttccccttgc ggaccatgat ggtgatcccc gaggtgaagt agtcgacgaa
    19681 gtcgatcctg gcctcgcgct ccttggtgtc gttcatcgcg gccatggtga ggtcgacccg
    19741 gccggattcg aggctcggga tgagcgagga gaaatcctcg tcctggtgct cgatgcggac
    19801 gccgagcttg gccgcgatcg ccttcgcgat gtcgacctcg tagccgatcg gggtccgccc
    19861 gtcggcggcg tagaagttgt tcggcggcga ctgcaggttc gtcgcgaggc gcagcgagcc
    19921 ggaaccggat acctgcggcg gcaacgccgc ggcgagcgcg ggatcggccg cgacggcgga
    19981 aacgatggaa ttcgtgtcgg ggatcgggct cggcttcggt gccgccgtgt cctccgcccc
    20041 gccacagccg gccaggcaca gtgccgtgat cgcgagcgcg ccgacgcggc ggacgagcgc
    20101 caccggcggg atcgccacgg atgtacctcc acggccagct acggccctcg gctgtgcgcg
    20161 gagaccgtac aaccggcggg tggaggcgtc aacggccggg gtggccgcgg ggtcgcggca
    20221 tccacaaagg actcatcggc gtcagcggcc ttcgccgggg gcggaatagg gcgcgccgtg
    20281 ctccagcgac gggctcacgc tcggcctggt gggatcggtg ccggggtcca ccgggttgac
    20341 ggtggtgccg ccccgcccgc gctccgcggc gaggccctgc ttgcgcgcga ccaggttctc
    20401 gccgacctgc tcgtcccgga tcctggacag caccgccagc gtgatgccgt gcgccagtgc
    20461 cagcacgagc agcaggatgc cgagcttggc caccaccttc ggcatgctgc tctcgtcacc
    20521 gccgaggctg atcgtggaca gcagcgcgag gatgcccagc acggcgaggt ggaacatcac
    20581 cgtgacgagc ctcgccatcg acgcgcccgc ttccggggcg ccgtaggagt tctccaggta
    20641 gcggcgcccg ctgtggtaga tgatctgccc gtcgatcgcc accagcacga tgccgatcag
    20701 caggaacgtg atgtacgcgt tcgtgttcac cggtgacctc ctcgttcacg tctcctcggc
    20761 ggagtacccg ctgggccggg gcggaaacgg cgcccgttcg tgcgctaggt tccggggtgt
    20821 gaccgaacac ctgagcatcc cgaccgcggt gggcagtttc gacgcgatcg ccgccggtcc
    20881 cgaggacggc gcgccggtgc tgctgctcca cggcttcccg gaggccgcga tctcctggga
    20941 gcaccaggtc ggctcgctcg gcgcgcaggg cttccgcgcg gtggcgccgg accagcgcgg
    21001 ctactccccc ggcgtccggc cggagaaccc ggccgagtac ggcatcggcg agc
//
