LOCUS       NZ_CP059997            22202 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 605270
            Orig. end                         :: 627472
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22202
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="6"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22202
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22202
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12202](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12202
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(126..851)
                     /locus_tag="HUW46_RS02870"
                     /old_locus_tag="HUW46_00576"
     CDS             complement(126..851)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227429.1"
                     /locus_tag="HUW46_RS02870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00576"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_215545775.1"
                     /transl_table=11
                     /translation="MSEQLIALVTGANKGIGYEIAAGLGALGWRVGIGARDETRREDAV
                     AKLRAADVDAFGVPLDVTDDASVAAAAALIDERAGRLDALVNNAGIAGAWPDEPSAATP
                     ETMRAVVETNVIGVVRVINAMLPLLRRSERPRIVNQSSHVASLTLQTTPGVELGGISGV
                     YSPSKTFLNAVTVQYAKELSGTAIKINNACPGYVATDLNGFRGTSTTADGAKIAIRLAT
                     LPDDGPTGGLFDDAGTVPW"
     gene            947..1783
                     /locus_tag="HUW46_RS02875"
                     /old_locus_tag="HUW46_00577"
     CDS             947..1783
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227428.1"
                     /locus_tag="HUW46_RS02875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00577"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_215545776.1"
                     /transl_table=11
                     /translation="METRELRYFVAVAEELHFGRAAERLGIAQPPLSRTITQLERRLGV
                     ALLERTSRKVSLTEAGSVLLDEGRAILGALAAAERRTQGAATSRPSLVLATKAGASGEL
                     VAKLLDAYAAEEGAVTVELLLCERQPQRTLHDGEADVALLHLPFDSIAGLDTEILHTEG
                     QIAILPTSHPLAAKPHVRMAEVCSLPELPIARWPGPGGVYPEGAGAEVRSQTQLFQLIA
                     LGRTTVVMPESCRANLLEGLAAVPVLDAPAVTTVIAWPPHSRSRALADLIRVATRL"
     gene            complement(1866..2324)
                     /locus_tag="HUW46_RS02880"
     CDS             complement(1866..2324)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS02880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_215545777.1"
                     /transl_table=11
                     /translation="MAFGVFAHPVDGFIALSRDTIGEFIGHGAVTCRRRRLILPWSPGT
                     AAAGALCWKCVGGPRRADREGDGMVGKVVLPALVMMAGTMVSIAPSASADTRSVPDCVS
                     YAIDEGEADVDIALQACVQSSLLDCYRTFRDDYGRQEWALEACKLRDS"
     gene            2633..2833
                     /locus_tag="HUW46_RS02885"
                     /old_locus_tag="HUW46_00580"
     CDS             2633..2833
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS02885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00580"
                     /product="hypothetical protein"
                     /protein_id="WP_215545778.1"
                     /transl_table=11
                     /translation="MNRLRDDLDYYLVTTPVSELSRQKLDGFYTEQQVIWAETSRHWVE
                     FRKLDRPPQVWQEPSPRDPQP"
     gene            2865..3218
                     /locus_tag="HUW46_RS02890"
                     /old_locus_tag="HUW46_00581"
     CDS             2865..3218
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672876.1"
                     /locus_tag="HUW46_RS02890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00581"
                     /product="VOC family protein"
                     /protein_id="WP_215545779.1"
                     /transl_table=11
                     /translation="MRATRVVANLRVADIEAAKDFYTGFLGLSTEEFNMGWVARYTSPD
                     TGANLQLVTRDATAPEDSVISVHTDDIDAAYAETRELGYEIVHPLTEEAWGLRRFFVRA
                     PDGTVINIANHRD"
     misc_feature    complement(2888..2908)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.15"
                     /tool="antismash"
     gene            complement(3227..3958)
                     /locus_tag="HUW46_RS02895"
                     /old_locus_tag="HUW46_00582"
     CDS             complement(3227..3958)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223724.1"
                     /locus_tag="HUW46_RS02895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00582"
                     /product="MerR family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_215545780.1"
                     /transl_table=11
                     /translation="MITIGQLARYVGVSTKTIRVYHDKGLLPEPERDASGYRRYGAAHA
                     IDLIKIRTLAEAGVPLARIRDLRSATDDEFRQALRRIDGDLSTRIRDLQATQERLRGLA
                     DGRSSALPAEVGSYLDQLARLGFSERWVALQNDLWILVFATHPDTAITLFRDQAQILAD
                     PALRELGLDYDRAYGLDPKDPRVDDLARRIVDATHARYGTGELPGYGADSAIPALIQGA
                     VNASSPAWHRLDTLIRAQLGV"
     misc_feature    complement(3626..3628)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            4015..4290
                     /locus_tag="HUW46_RS02900"
                     /old_locus_tag="HUW46_00583"
     CDS             4015..4290
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013223725.1"
                     /locus_tag="HUW46_RS02900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00583"
                     /product="hypothetical protein"
                     /protein_id="WP_215545781.1"
                     /transl_table=11
                     /translation="MVNTNFNRETLRALADEGNETALDRLADLADARGDLGELNELLDE
                     GSARAGHVLTRRAVAAGDLLELQRISDAGCEEAGEELERLLTTRQD"
     misc_feature    complement(4019..4033)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.93"
                     /tool="antismash"
     gene            4406..5065
                     /locus_tag="HUW46_RS48185"
                     /old_locus_tag="HUW46_00584"
     CDS             4406..5065
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS48185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00584"
                     /product="hypothetical protein"
                     /protein_id="WP_254125759.1"
                     /transl_table=11
                     /translation="MKPPRDEKGRFAPYKTKARATVAAAATAGVVAFGGGGAGGGAASV
                     GSGAESGAGSVNAVARSVGKDLARKGLRREALKKLGFKIAKEAVKTELRCATASFGRVR
                     QFFLAHPCRKLDRQVIAVGDGAGNTVAVSIVWVRMRSGDQVTGLKDVIDEHGSGDISPL
                     GGAVLGLAGVKFTGEHYDSRADGSLLVIAETEAAGGHSSDRQLDDAAHVASLFPPL"
     gene            complement(5072..5446)
                     /locus_tag="HUW46_RS02910"
                     /old_locus_tag="HUW46_00585"
     CDS             complement(5072..5446)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229301.1"
                     /locus_tag="HUW46_RS02910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00585"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_215545782.1"
                     /transl_table=11
                     /translation="MSDVAELSLVEEWHQLLARHAAVFNALECALQEEHGLGVSEFEAL
                     EALAVCDHQCRAADLTEAVHLSQSATSRLVARMEREGLVERAMCDVDRRGIFVTLTEAG
                     WTRFRTAKPTHRRVLRETLR"
     misc_feature    complement(5478..5492)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.56"
                     /tool="antismash"
     gene            5534..6991
                     /locus_tag="HUW46_RS02915"
                     /old_locus_tag="HUW46_00586"
     CDS             5534..6991
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671986.1"
                     /locus_tag="HUW46_RS02915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00586"
                     /product="MFS transporter"
                     /protein_id="WP_215545783.1"
                     /transl_table=11
                     /translation="MSTSAHLSTSSTRWDARLWGVLLTVSTVVGLDALDVSMVGVALPA
                     IRSDLGLSTSALQWVVSGYVLGYGGLLLLGGRTADLLGRRRVFLVAVTVFAAASLLGGV
                     VDDGALLIASRFIKGLAAAFTAPAALSIITTTFQEGPARNRAISIFAVFGASGYSAGLV
                     FSGLLTEVGWRWTFLLPVPIALAALAFAIKLIPSYDRDDSGAGYDIPGAITGAVGSLLL
                     VFGVVEAPQVGWAAPRTLVTFAVAIALLAAFVVIEKRSSHPLLRLGILRSGPLARANLG
                     GALFFGAYIGFQFVVMLYLQSVLGWSALQTALGFLPAAAIVAFGSPRIEPLIDRVGTPR
                     TILAGVVAHVIGYALFLRVDEHSGYAGSVLPSMILLGIGFTLAFSSLNIQATAGISDDE
                     QGLAGGLLNTSLQVGGAIGLAVVTAVLTANGGSEASAGALLTGLTPVLSVVTGIAVLGL
                     LVALSGVLKRRRAEEPVAEPELALAAK"
     gene            7125..9056
                     /locus_tag="HUW46_RS02920"
                     /old_locus_tag="HUW46_00587"
     CDS             7125..9056
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558766.1"
                     /locus_tag="HUW46_RS02920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00587"
                     /product="UvrD-helicase domain-containing protein"
                     /protein_id="WP_215545784.1"
                     /transl_table=11
                     /translation="MGISAHARRQAERQAAELVARLPDLGPPRRRVLTALIARTVESWH
                     VFVRDDLPAPGTADAYLIGPGGVFAITVADGAVGEAAARATIRHAEERFAGLPGLHGQV
                     VSGSAVHFVVVGGEAPGHWRVREAELDKLFRRDALHLDRRRVQAIVDRVAARLRGYSRF
                     AVGKPEDTAEPDGLLDAEALTEDQVEAAQNRPFDTWLTFLHPQQQAVVTRNYNGPARIS
                     GPAGTGKTVVALHRLRHLARRSVGPVLFTTFVRTLPLVHRAAFERLAPEMTDRAEFTNL
                     HAWARAFLASRGRAVEVDSGRVGTARSRAWIAHRDELEGIEPSPQYWETEIDRVLKGRG
                     IDTFEKYAGAYRKGRRINLNARQKALVWAYYETYQRNLAADGLHDHNDVLAIALDELVR
                     EPLENAYAAVVVDEVQDITLTGLRLLRELAGDGPNRLLLVGDGQQQVYPGGWRLSDAGI
                     PIQGRGEVLRVNYRNRVEVLTFAQRFDAMNHVDDLDGAAGVALRDAESANGGGEVRSWR
                     GTAASLPAALLSEVDKLPVPRGEAAVITFHHQDVKRCTEILRKAGVETRSLDHFSGESD
                     DRLKIGTVHRAKGLDFRAVLVVQTTDPEPAGGDAGRERRELHDRQHLVAATRARDFVWW
                     GLVGNTGD"
     gene            9075..9848
                     /locus_tag="HUW46_RS02925"
                     /old_locus_tag="HUW46_00588"
     CDS             9075..9848
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS02925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00588"
                     /product="ParB N-terminal domain-containing protein"
                     /protein_id="WP_215545785.1"
                     /transl_table=11
                     /translation="MGGLRGRRAADGLMPLDDALGALGGDGVMGRRFAEVPLGRIVGTS
                     ARACDFDAEFKLVNRRLRDRWHGVAKVMESGSEPPVDLVQLGELYFVVDGHHRVSVARA
                     RGWPVVPAQVVQICTIAYAMGCLRLAHLPSKAAERRFLDRVPLPADVRADLWLDEPADW
                     SRLADAAESWAFRRALDGRPFTDREELAGVWWRDEVLPVITRLRDAGKCVDLRDVETYA
                     VALATRDHHGWHVWPEDLPERVGAPARQGVRRLGR"
     gene            10001..12202
                     /locus_tag="HUW46_RS02930"
                     /old_locus_tag="HUW46_00589"
     CDS             10001..12202
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643805.1"
                     /locus_tag="HUW46_RS02930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00589"
                     /product="germacradienol/geosmin synthase"
                     /protein_id="WP_254125761.1"
                     /sec_met_domain="T1TS (E-value: 4.3e-74, bitscore: 249.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPYPARLNPNLERARQNSKSWAYAMDMIDVPQHGTAIWDEHDLDS
                     HDYALLCSYTHPDCSGPVLDLITEWYVWVFYFDDHFVELYKRTPDLQGARAYLDRLPSF
                     MPVDGEITAVPENPVEKGLADLWSRTVPARSACWRRRFAESTKNLLDESLWELGNISEN
                     RLANPIEYIEMRRKVGGAPWSANLVEHAVDAEVPAAIAATRPMHVVRDTFADAIHLRND
                     LFSYEREVLDEGELSNGVLVLERFLGIGTQEAADAVNDLLTSRLHQFEHTALTELPPLV
                     EEHALDPVQRMGVFAYLKGLQDWQAGGHEWHLRSSRYMNGSTEESRAAQPVLGGPSGIG
                     TSAARISSSIAGTLPQRARSFSHVPFEKVGPSPIPDFYQPYELRMSPHLDTARENVVEW
                     AKNVGILDEAVWDEEKLRAYDVALCGAGIHPDASPEELDLTSAWLAWGSYADDYYPAVF
                     GRTPDPAAAKVCTARLSELMPVDGPPKTAPVTGLERGLAEIWARTAAPMDVPARRAFRR
                     AVEEMLASWLWELANHRANRIPDPVDYIEMRRKTFGSSLTMGLSRIGHGRTVPPELYRT
                     RPVQNLENSAMDYAALLNDVFSYQKEIEYEGELHNGVLVVRNFLDCTPDRALAVVNDLM
                     TARMKQFQHVVELELPALAEDHDLGHDVRATLIGYVEELKSWISGLLNWHRGCHRYAEE
                     DLRRNFGRDRAPAAGSLTGLGTAAARIGRTPVRAGAGAG"
     gene            12213..12665
                     /locus_tag="HUW46_RS02935"
                     /old_locus_tag="HUW46_00590"
     CDS             12213..12665
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009949038.1"
                     /locus_tag="HUW46_RS02935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00590"
                     /product="DUF6314 family protein"
                     /protein_id="WP_215545787.1"
                     /transl_table=11
                     /translation="MDAYPVADLVGYLSGRWRLDREIVAASGEPLGRFGGTCAFDADGE
                     ELVQRERGVLDFGAHHGEATRELRFRLTGPGSADVHFDHGGFFHTVDLTSGSWLASHPC
                     AEDLYRVEYRVLGADHWRHEWTVRGPSKDHVIFSAFRRDQGLPSTG"
     gene            complement(12641..13099)
                     /locus_tag="HUW46_RS02940"
                     /old_locus_tag="HUW46_00591"
     CDS             complement(12641..13099)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS02940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00591"
                     /product="hypothetical protein"
                     /protein_id="WP_215545788.1"
                     /transl_table=11
                     /translation="MSTEGAHHRVLLGNPHGDHLSIALLGRAHPGADDYWDGNWLLSPI
                     AIHAGGFQGTVGATLRTSELESFHRELSALYETLSGAAVLDSMEDWVKLTVRCEPSGVL
                     AVAGTLLDQAGHGNQLRFELGGLDQTHLPPVLDELEDCLRAYPVLGKP"
     gene            complement(13180..14364)
                     /locus_tag="HUW46_RS02945"
                     /old_locus_tag="HUW46_00592"
     CDS             complement(13180..14364)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417074.1"
                     /locus_tag="HUW46_RS02945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00592"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_215545789.1"
                     /transl_table=11
                     /translation="MKNTTVLISGASIAGPALAYWLVRYGCSVTIVERAEGRMRPGGQA
                     VDVRGPALEVIERMGIADAVRARSTRMRGMTMVDESGAELYSSTEHTFTGGDLANADIE
                     IMRDDLALLLQEAAGDEVEYLTGDSIASLAEDADGVHVTFEKAAPRRFDLVVGADGLHS
                     TVRSLAFGPERDYISHLGTYLAVYTAPNFLGLDHWQVFCQAGAVGGGMMSARDTTECRV
                     YVGFESPEPVEYDYRDIDQQKRILAERLEGAGWEFPKALTYSWDAPDFSFDSMSQIHLD
                     RWSRGRVVLIGDAGYCGSPMSGQGTSMALVGAYVLAGELKAAEGDHETAFACYETEIRD
                     YVAANQRLALTNRARVEAQTRAAMGGAEAAEPVEITTEPEDFDGVVGALVLKDY"
     gene            complement(14499..15377)
                     /locus_tag="HUW46_RS02950"
                     /old_locus_tag="HUW46_00593"
     CDS             complement(14499..15377)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020498.4"
                     /locus_tag="HUW46_RS02950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00593"
                     /product="glycoside hydrolase domain-containing protein"
                     /protein_id="WP_215545790.1"
                     /transl_table=11
                     /translation="MTTGLDYSAGRIPGRAIRDAGHSFVIRYAGTPGRAKNIKAAEYAD
                     LVANGVSVWLVYENGVDDAMGGFRGGVAAANAARADAAAIGYANGPIFFCADRHLAPGE
                     VATALTYLDGAASVLGRERVGAYGFSEFINPARDGGRAAYFWQCGSRSAVRPGVHVYQR
                     NTGAASVGGIQCDINDLLIPITKGDDMSANDVIGKRPDGSDITIGDALANLYLGAFYGG
                     GGSGARAVYPTVNAINDDLGKVWDTTGTVTAGGASADMYTRLQKVEGKVDELLAAIKNL
                     SAGRDPVAAKP"
     gene            complement(15484..15978)
                     /locus_tag="HUW46_RS02955"
                     /old_locus_tag="HUW46_00594"
     CDS             complement(15484..15978)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003079606.1"
                     /locus_tag="HUW46_RS02955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00594"
                     /product="DUF4262 domain-containing protein"
                     /protein_id="WP_215545791.1"
                     /transl_table=11
                     /translation="MCWKCDQPGGSRLDYLDELRGTITECGWAVQSIERDRLHPPRAYT
                     VGLTPRGRPELVVTGLPPGKAGALLNSVAAHVLHADAPTAGEQIPLRGGPLIEIVEVTE
                     PSAHLFTAIELYGGGVRAVQLVYADDRGHWPWDRGFRGGKGGQPVLGHRHAAADRSARS
                     G"
     tRNA            complement(16061..16150)
                     /anticodon=(pos:complement(621384..621386),aa:Ser,seq:cga)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS02960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00595"
                     /product="tRNA-Ser"
     gene            complement(16061..16150)
                     /locus_tag="HUW46_RS02960"
                     /old_locus_tag="HUW46_00595"
     tRNA            complement(16173..16264)
                     /anticodon=(pos:complement(621498..621500),aa:Ser,seq:gct)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS02965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00596"
                     /product="tRNA-Ser"
     gene            complement(16173..16264)
                     /locus_tag="HUW46_RS02965"
                     /old_locus_tag="HUW46_00596"
     tRNA            complement(16303..16375)
                     /anticodon=(pos:complement(621610..621612),aa:Leu,seq:cag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS02970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00597"
                     /product="tRNA-Leu"
     gene            complement(16303..16375)
                     /locus_tag="HUW46_RS02970"
                     /old_locus_tag="HUW46_00597"
     tRNA            complement(16416..16489)
                     /anticodon=(pos:complement(621723..621725),aa:Leu,seq:gag)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS02975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00598"
                     /product="tRNA-Leu"
     gene            complement(16416..16489)
                     /locus_tag="HUW46_RS02975"
                     /old_locus_tag="HUW46_00598"
     tRNA            complement(16590..16664)
                     /anticodon=(pos:complement(621897..621899),aa:Arg,seq:acg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS02980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00600"
                     /product="tRNA-Arg"
     gene            complement(16590..16664)
                     /locus_tag="HUW46_RS02980"
                     /old_locus_tag="HUW46_00600"
     tRNA            complement(16670..16755)
                     /anticodon=(pos:complement(621990..621992),aa:Tyr,seq:gta)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS02985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00601"
                     /product="tRNA-Tyr"
     gene            complement(16670..16755)
                     /locus_tag="HUW46_RS02985"
                     /old_locus_tag="HUW46_00601"
     misc_feature    16841..16855
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.3"
                     /tool="antismash"
     misc_feature    complement(16991..17006)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.23"
                     /tool="antismash"
     misc_feature    complement(17002..17017)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     gene            complement(17309..18085)
                     /locus_tag="HUW46_RS02990"
                     /old_locus_tag="HUW46_00602"
     CDS             complement(17309..18085)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420944.1"
                     /locus_tag="HUW46_RS02990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00602"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_215545792.1"
                     /transl_table=11
                     /translation="MRDAVIAAAVFLHAHSGEPIRLGDVADHVGYSPFHLARAFTRELG
                     TSPVRVLAAHRFHRAKRLLLDGDDRIADICHAVGFSSVGTFTTRFAEAVGTSPTEFRRL
                     PHDLADAPPRPVSTSGEARGGGGVAGSVRIGPSAAAVLGPDPLVFVGLYPARSARGQPV
                     AGAMLAGPGEFLLIDVPPGLFWVLATALSTRGDYDGLLVPGESVIGTSPRMLRMRPGER
                     HLCDIALEPVERWQPPVLAALPALASDIAQHWRRRA"
     gene            18435..19109
                     /locus_tag="HUW46_RS02995"
                     /old_locus_tag="HUW46_00603"
     CDS             18435..19109
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004558754.1"
                     /locus_tag="HUW46_RS02995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00603"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_215545793.1"
                     /transl_table=11
                     /translation="MSEEPEYRQHRFSPPPGATEIFLVRHGESAPARASAPFPMVEGQA
                     DPDLAPEGREHAERVGERLANERLDALYVTTLRRTAQTAAPLAAKLGIEPVVTPLLREV
                     HLGEWEGGLFRRNTAEGHPVARRLWAEQRWGVIPGAEDVAAFAARVKAGLTEVAAAHPD
                     QRVAVFTHGGVIGEAMAQASGSEPFAFLGADNGSITHLVLTADNWLVRRFNDTAHLAAP
                     LG"
     gene            complement(19072..19848)
                     /locus_tag="HUW46_RS03000"
                     /old_locus_tag="HUW46_00604"
     CDS             complement(19072..19848)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671978.1"
                     /locus_tag="HUW46_RS03000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00604"
                     /product="ABC transporter permease"
                     /protein_id="WP_215545794.1"
                     /transl_table=11
                     /translation="MTNGAIVVGPALGAVLVLFVALGAAVLWLGGLGRGRAIVSAAVRA
                     AVQLAAVSLVIVAVLRSGWWTALFVLLMFAVAAVTSARRIGVPRRGPGFGWTAVAIGAG
                     VVPVLAVVLAAGVLPLRPVAVVPIAGIVIGGAMSATSQAGRRALDELETRHGEYEAALA
                     LGFTPRLAALEICRPSASQALIPALDQTRTVGLVTLPGAYVGVLLGGAGPVQAGVTQLL
                     VLIGLLAAEAVSVLVTVQLVAAGGLSRAARPGARCR"
     gene            complement(19864..20382)
                     /locus_tag="HUW46_RS03005"
                     /old_locus_tag="HUW46_00605"
     CDS             complement(19864..20382)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017260.4"
                     /locus_tag="HUW46_RS03005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00605"
                     /product="MmpS family transport accessory protein"
                     /protein_id="WP_215545795.1"
                     /transl_table=11
                     /translation="MAEHPRGVFTTSRARRPKSGSGVLLACSLAVLGIVVVSVLVAANR
                     DQGGGGSATPGAHALPALPVLTSAPEAHGAVVRTRDVTYELAGDSGAVHVTFVAKGADV
                     QQLNGVPTPWTQTVSRADPENGPHYVTVSAQNGGHGTLRCRILVDGKVVSERSTATDYG
                     VVMCAKVLD"
     misc_feature    20414..20428
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
     gene            complement(20620..21024)
                     /locus_tag="HUW46_RS03010"
                     /old_locus_tag="HUW46_00606"
     CDS             complement(20620..21024)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007028103.1"
                     /locus_tag="HUW46_RS03010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00606"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_215545796.1"
                     /transl_table=11
                     /translation="MTPPFVDSLAWILVRDRALLSVRTKGKDKFYLPGGKREPGESDVA
                     ALCREIREELGVELDPMSFSFFTALRERADGYADGREVRMTCFTAEHRGELAPSREIAE
                     HRWLTTADAALCPPAGRKVLAMLGDAGLIG"
     gene            complement(21043..21804)
                     /locus_tag="HUW46_RS03015"
                     /old_locus_tag="HUW46_00607"
     CDS             complement(21043..21804)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671974.1"
                     /locus_tag="HUW46_RS03015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00607"
                     /product="MgtC/SapB family protein"
                     /protein_id="WP_215545797.1"
                     /transl_table=11
                     /translation="MTLAFSLGEPSGQGWTQVVELLIALVLCSLIGLERELKQKSAGLR
                     THTLVGLGAALFFLVSKYGFTDVLEQGRIVLDPSRVAAQIVSGIGFIGGGLIFVRRDVV
                     RGLTTAAVVWVSVAVGCACAAGLPLLAAFVTAAHFLVVYGYPPLIRAFTRSRPASEVVR
                     VSYRDGEGALRGILEVATNAGYVVEQVHTERRQMDEDDEEGRMKVRTAQVIDLRMRLHG
                     PPKTFTVLVSTLSEESGVLSVDVGDIDDTSE"
ORIGIN
        1 gtcgccatgg ccacctcgca tcacctcgaa cacgtatcgc gaagaacagc gaccgacctc
       61 tgatttcgac cttttcgtcg cgaactggca gtgcttcgcg gccatctggg ccgtgtagtc
      121 gcgtttcacc agggcacagt tccggcgtcg tcgaacaggc ccccggtcgg accatcgtcc
      181 ggcaacgtcg cgagccggat ggcgatcttg gcgccgtccg cggtcgtgct ggttccgcgg
      241 aagccgttga gatctgtcgc gacatagccg gggcaggcgt tgttgatctt gatggcggtg
      301 ccgctcaact ccttggcgta ctgcacggtg acggcgttga ggaacgtctt cgacggtgaa
      361 tagacaccac tgatcccgcc gagttcgacg ccaggcgtcg tctgcagggt cagagaagcg
      421 acgtggctgg actggttgac gatccgcggg cgttcggaac ggcgcaggag cggcagcatc
      481 gcgttgatga cccggaccac gccgatcacg ttggtttcca ccacagcgcg catggtttcc
      541 ggtgtggcgg cggaaggttc atccggccac gctccggcga taccggcatt gttgaccagt
      601 gcgtccagcc gcccggcgcg ctcgtcgatc agtgcggcgg cggccgcgac gctcgcgtcg
      661 tcggtcacgt cgaggggcac accgaacgcg tcgacgtcgg ccgctcgcag tttcgccacg
      721 gcgtcttctc ggcgcgtttc gtcccgtgcc ccgattccga cacgccagcc cagcgcgccg
      781 agcccggccg cgatctcgta cccgattccc ttgttcgcgc cggtgaccag cgcgatcagc
      841 tgttcgctca tgtggttgat cgtggccgcg gaccggcggg gaaccaacac cgtctgggtt
      901 tcgcggcaat acccggcagg tatcgatcgg gcggtagcct gatccggtgg agacgcggga
      961 gcttcggtac ttcgtcgcgg tcgccgagga gttgcacttc ggccgggccg ccgaacgcct
     1021 cggcatcgcc cagccgccgc tctcgcggac gatcacccag ctcgaacgac ggctcggcgt
     1081 cgcgctgctg gaacgcacca gccgcaaggt ctccctcacc gaagccggat cggtactgct
     1141 ggacgaaggc agagccatcc tcggcgcgct ggccgcggcc gaacggcgca cccaaggcgc
     1201 cgcgacgagt cggccttcgc tcgtactggc caccaaggcg ggcgcctccg gtgaactggt
     1261 ggcgaagttg ctcgacgcct acgcagccga agaaggcgcc gtcaccgtcg aactgctgct
     1321 ctgcgaacgc cagccccaac gaacgctgca cgacggcgag gcggacgtcg cgctgttgca
     1381 cctgccgttc gactcgatcg ccggactgga caccgaaatc ctgcacaccg aggggcagat
     1441 cgccatcctt cccacttcac atccgctcgc ggccaagccc cacgtccgga tggcggaggt
     1501 ctgctcgctg cccgaactcc ccatcgcccg ctggcccggc cccggcggcg tctaccccga
     1561 gggcgccggt gccgaggtgc gcagccaaac ccagctcttc caactgatcg cactcggccg
     1621 caccactgtg gtcatgcccg aatcctgccg cgccaacctg ctcgaaggcc ttgccgcggt
     1681 accggtcctg gacgcgccgg ccgtcacgac cgtgatcgcg tggccacccc acagccgatc
     1741 ccgtgcactc gccgacctga tccgtgtagc cacccgcctc tgatcactcg gcactcgcca
     1801 acgacgcggg tcgctggacc gcaacgcgaa ccagcaggct cacccgcggc gttcatcttc
     1861 gcgagtcacg aatcccggag cttgcaggct tccagcgccc attcttgtcg gccgtaatcg
     1921 tcgcggaagg tccggtagca atcgaggagc gagctttgga cacaagcctg gagagcgatg
     1981 tcgacgtctg cctctccttc gtctatcgcg taactcacgc agtccgggac actccgggtg
     2041 tccgccgacg cgctcggcgc gatcgagacc atcgtgcctg ccatcatcac cagtgcgggg
     2101 agtaccacct tgccgaccat gccgtcacct tcccggtccg cgcggcgcgg gccgccaacg
     2161 cacttccagc acagcgctcc ggcagccgcg gtgccagggc tccacggcag gatcagccga
     2221 cggcgtcggc acgtcaccgc accgtgaccg atgaactcac cgatcgtgtc ccgggacagg
     2281 gcgatgaaac cgtcaacggg gtgagcgaat accccgaatg ccacttcgtc atctctgtgt
     2341 ttcgccgaat gatcggaaac cggctcttgc caaggcgatc cgggtcggcg agcctggcgc
     2401 gatgaaggcg aagcgccccg gtcacgagga actgacttcc gagaaggggc tgcctcgaac
     2461 tcgccgggcg gatggcggat attcccttgc gcgaagcgat gttgggcttt cgcgacctcg
     2521 tgtcggccga catggcgtgg atcgattccc gcaagaggcg gtaccgagtg cctgcctacc
     2581 gaacccggat cgcgacgctc gtgctgacag cgtcctccac catcgtgctc gcatgaaccg
     2641 cctgcgcgat gacctggact actacctggt caccacaccg gtctccgagc tgagcaggca
     2701 gaaactggat ggcttctaca ccgaacaaca ggtcatctgg gcggagacca gccgccactg
     2761 ggtggagttc cgcaaactcg accgcccgcc gcaggtttgg caggagccgt cgccgcgcga
     2821 cccgcaaccg taatctgaga atccctgaca gacaggagaa ccgtatgcgc gcgacacgcg
     2881 tcgtggccaa tcttcgggtg gccgatatcg aggcggcgaa ggacttctac accgggtttc
     2941 tcgggttgag caccgaggag ttcaacatgg gctgggttgc ccgctacacc tcgcccgaca
     3001 ccggggccaa cctccagctc gtgaccaggg acgcgaccgc gcccgaggat tcggtcatct
     3061 ccgtccacac ggacgacatc gacgccgcgt acgcagaaac gcgggaactc ggctacgaga
     3121 tcgtgcaccc gctgaccgaa gaagcatggg ggctgcgccg gttcttcgtc agggcaccgg
     3181 acggcaccgt gatcaacatc gcgaaccacc gggactgaat cgggcgtcag acaccgagtt
     3241 gggcacggat cagggtgtcc agccggtgcc atgccggtga cgaggcgttg acggctccct
     3301 ggatcagcgc cgggatcgcg gagtcggctc cgtatccggg cagctcgccg gttccgtagc
     3361 gggcgtgggt ggcgtcgacg atccggcggg cgagatcgtc gacgcggggg tccttcgggt
     3421 ctaggccgta cgcacggtcg tagtcgaggc cgagttcgcg caacgccggg tccgccagga
     3481 tctgggcctg gtcgcggaac aaggtgatcg cggtgtccgg gtgcgtggcg aacacgagaa
     3541 tccacaagtc gttctggagc gccacccatc gctcgctgaa accgaggcgg gccagttggt
     3601 cgaggtagct tccgacttcg gccggtaacg cggaggaacg cccgtcagcg agtccccgaa
     3661 ggcgctcctg agtcgcctgc aagtcacgga tgcgggtgga caggtcaccg tcgatccggc
     3721 ggagggcttg ccggaactcg tcgtcggtgg cggaccggag atcgcggatg cgggcaaggg
     3781 gaaccccggc ttcggcgagt gtccggatct tgatcaggtc gatcgcgtgg gccgctccgt
     3841 atcgccggta gccggaggcg tcgcgctccg gttcggggag caggcccttg tcgtggtaga
     3901 cgcggatcgt cttggtcgac acgccgacgt acctggcgag ctgtccgatg gtgatcaccc
     3961 ggccatgatc tcgcacttga cgttgccctt ggggcaaggt tgcagcatgt cttcatggtg
     4021 aacacgaact tcaaccggga aaccttgcgc gcgctcgcgg acgagggcaa cgagaccgca
     4081 ctggaccgct tggccgatct cgccgacgcc cgcggggatc tcggagaact gaacgaattg
     4141 ctcgacgagg gatccgcgcg cgccgggcac gtgctcaccc gccgtgccgt cgcggcgggt
     4201 gatctgcttg agctgcaacg aatctccgac gccggatgcg aggaggccgg tgaagaactg
     4261 gagcggttgt tgacgacgcg gcaggattga atccgccccg aacgacggcc ggatactctt
     4321 ttcgggcgat aaacaagcga aaagatcgcc accggaaaag tcggcgggaa tgatcggacc
     4381 ccggactcgg ggaggggtca cgaccatgaa accgccacgc gatgaaaaag gccgtttcgc
     4441 gccatacaag accaaagcga gggcgaccgt cgccgcagcc gccacggccg gtgtggtcgc
     4501 cttcggcggc ggaggtgcgg gcggcggcgc ggcttcggtc ggctcgggcg cggaatccgg
     4561 tgccgggtcg gtcaacgcgg tcgcgagatc ggtgggcaag gatctcgcgc gcaagggact
     4621 gcgccgcgaa gcgttgaaga aactggggtt caagatcgcc aaggaggcgg tgaaaaccga
     4681 gctgcgctgc gccaccgcct cgttcggacg ggttcggcag ttcttcctgg cgcacccctg
     4741 ccggaagctc gatcgccagg tcatcgccgt gggcgacggt gcgggcaaca ccgtggcggt
     4801 gtcgatcgtc tgggtgcgca tgcgttctgg cgaccaggtg accgggctga aggacgtcat
     4861 cgacgagcac ggttcgggcg acatttcacc gctcggcggg gccgtgctcg gactggccgg
     4921 ggtgaagttc accggcgagc actacgactc gcgcgccgac ggttcgctgc tcgtgatcgc
     4981 ggaaaccgag gccgcgggcg ggcattcgag cgatcgccag ctcgacgacg cggcccacgt
     5041 agcgagtttg ttcccgccgt tgtgagccgc ttcagcgcag ggtttcccgg agcacgcgcc
     5101 ggtgggtcgg cttcgccgtg cggaaccggg tccagcccgc ttcggtgagg gtgacgaaga
     5161 ttccgcgccg gtccacatcg cacatcgcgc gctccacgag accttcgcgt tccatcctgg
     5221 cgacgaggcg cgaagtggcg ctctggctca ggtgcacggc ttcggtgagg tcggcggccc
     5281 ggcactggtg atcgcagacg gcgagcgctt cgagtgcttc gaactcgctg acgccgagcc
     5341 cgtgctcttc ctgcagggcg cactcgagtg cgttgaaaac ggcagcgtgc cgcgcgagga
     5401 gctggtgcca ctcctccacc aggctcagct cagcgacgtc gctcacgtcg gcgaccttaa
     5461 catgcacgcg aatctgatgc aactgaattt tatgcgttgt cattagatgc gcatgcatgt
     5521 agcgtacgga tccatgagca cttccgcgca cttgtccacc tcttcaaccc ggtgggacgc
     5581 ccgcctctgg ggcgtcctgc tcaccgtgtc caccgttgtc ggcctcgacg cgctcgacgt
     5641 ctcgatggtc ggggtcgcgc tccccgccat ccggtccgac ctcggtcttt ccaccagtgc
     5701 cctgcaatgg gtcgtcagcg gctacgtgct cggctacggc ggactcctgc tcctcggcgg
     5761 gcgcaccgcc gacctgctcg gccgccgtcg cgtgttcctc gtcgcggtca ccgtgttcgc
     5821 ggccgcttcc ctgctcggcg gcgtcgtcga cgacggcgcg ctgctgatcg ccagccggtt
     5881 catcaagggg ctcgccgcgg cgttcaccgc accggccgcg ctgtccatca tcaccacgac
     5941 cttccaggaa ggccccgccc gcaaccgggc gatcagcatc ttcgcggtct tcggcgccag
     6001 cgggtactcc gccggcctgg tcttctccgg gctgctgacc gaggtcggct ggcgctggac
     6061 gttcctgctg ccggtgccga tcgcgctcgc cgcgctggcc ttcgcgatca agctgatccc
     6121 cagctacgac cgggacgact ccggcgctgg ctacgacatc cccggcgcga tcaccggcgc
     6181 ggtggggtcg ctgctgctgg tcttcggtgt cgtcgaagcg ccccaggtcg gctgggccgc
     6241 gccgcgcacg ctcgtcacct tcgccgtggc catcgcgctg ctcgccgcgt tcgtcgtgat
     6301 cgagaagcgg agcagccacc cgttgctgcg actgggaatc ctgcgttcgg gcccgctggc
     6361 cagggcgaac ctcggcggtg cgctgttctt cggcgcctac atcgggttcc agttcgtggt
     6421 gatgctgtac ttgcagtcgg tgctcggctg gagcgcgctg cagaccgcgc tcgggttcct
     6481 gcccgccgcg gcgatcgtgg ccttcggttc gccgaggatc gaaccgctga tcgaccgggt
     6541 cggcaccccg cgcacgatcc tcgccggggt cgtcgcccac gtgatcggct acgcgctgtt
     6601 cctccgcgtc gacgagcact ccggctacgc gggttcggtg ctgccgagca tgatcctgct
     6661 cggaatcggg ttcacgctgg cgttctcctc gctcaacatc caggcgaccg cgggcatctc
     6721 cgatgacgaa cagggcctcg ccggcggcct gctcaacacc tcgctgcaag tcggcggtgc
     6781 catcgggctc gcggtggtga ccgcggtgct caccgccaac ggcggcagcg aagcatcggc
     6841 gggcgcactg ctcaccgggc tgaccccggt gctgagcgtc gtcaccggga tcgcggtgct
     6901 cggcctgctg gtcgcgctgt ccggggtgct caagcggcgt cgcgccgaag agcccgtggc
     6961 cgagccggaa ctcgcgctcg ccgcgaaata ggagtagccg aacgcgcctg cctgccgttc
     7021 tcgggggacg gcaggcaggc gcgttccggc atccgggcga ctacccttcg cgcacgctct
     7081 tgcttacggt ggttccgtat cgccactatt cgcgaggggg ccgagtgggt atcagcgcgc
     7141 acgcgcggcg gcaggccgaa cggcaggcgg ccgaactcgt cgcgcgcctt ccggacctcg
     7201 ggccaccacg gcgccgggtg ctcaccgcgc tgatcgcgcg aacggtcgag agctggcacg
     7261 tgttcgtccg cgacgacctg cccgcgccgg gcaccgcaga cgcctacctg atcggccccg
     7321 gtggggtctt cgcgatcacg gtcgccgacg gcgcggtcgg cgaagcggcc gcgcgggcga
     7381 cgatccggca cgcggaagag cggttcgccg gtcttcccgg gctgcacggc caagtcgtct
     7441 ccgggagcgc ggtgcacttc gtggtcgtcg gcggcgaagc acccggccac tggcgggtcc
     7501 gggaagccga gctggacaag ctgttccggc gcgacgcgct ccacctggac cggcggcggg
     7561 tacaggccat cgtggatcgc gtcgcggcac ggctgcgcgg gtattcgcgt ttcgcggtcg
     7621 gaaagccgga ggacaccgcc gagcccgatg gcctgctcga cgcggaggcc ctgaccgaag
     7681 accaagtcga ggccgcccag aaccgcccgt tcgacacctg gctgaccttc ctgcacccgc
     7741 agcagcaagc cgtggtcacc cgcaactaca acggtcccgc ccggatcagc ggccccgccg
     7801 ggaccgggaa gaccgtggtc gcgttgcacc ggctgcgcca tctcgcgcgc cgcagtgtcg
     7861 ggccggtgct gttcacgacg ttcgtcagga cgctccccct cgtgcaccgc gccgcgttcg
     7921 aacggctggc gccggaaatg acggaccggg ccgagttcac caacctgcac gcgtgggcac
     7981 gggcgttcct ggcgagccgt ggccgcgcgg tcgaggtcga cagcggacgg gtcggcacgg
     8041 cgcgaagccg ggcgtggata gcgcatcgcg acgagctgga aggcatcgaa ccttcgcccc
     8101 agtactggga aaccgagatc gaccgcgtgc tcaagggcag ggggatcgac accttcgaga
     8161 agtacgccgg cgcctaccgg aaggggcgcc gcatcaacct gaacgcccgg cagaaggcac
     8221 tggtgtgggc gtattacgag acctaccaac ggaatctcgc cgccgacggg ctgcacgacc
     8281 acaacgacgt gctcgccatc gcgctcgacg agctggtcag ggagccgctc gaaaacgcgt
     8341 acgcggccgt cgtggtggac gaggtgcagg acatcacgct gaccggcctg cggctgctgc
     8401 gcgagctggc cggggacggg ccgaaccggc tgctcctggt cggcgacggg cagcagcagg
     8461 tgtacccggg cggctggcgg ctttccgacg cgggcatccc gatccagggc cgcggcgagg
     8521 tgctgcgggt gaactaccgc aaccgcgtcg aggtgctcac cttcgcgcag cggttcgacg
     8581 cgatgaacca cgtcgacgat ctcgacggcg ccgccggtgt cgcgctgcgg gacgccgaat
     8641 cggccaacgg cggcggcgaa gtgcgctcgt ggcgcggcac cgccgccagc ctccccgccg
     8701 ccctgctgtc cgaagtggac aaacttccgg tgccgagggg cgaagcggcg gtgatcacct
     8761 tccaccacca ggatgtcaag cgctgcaccg agatcctgcg caaggcgggt gtcgaaacga
     8821 gatcgctcga ccacttctcc ggcgagtccg acgaccggct gaagatcggc accgtgcacc
     8881 gcgcgaaggg actcgacttc cgcgccgtgc tggtcgtcca gaccaccgac cccgaaccgg
     8941 caggcggcga cgcgggccgg gagcggcgcg agctgcatga ccgccagcac ctcgtggccg
     9001 ccacgcgcgc acgggacttc gtctggtggg ggctggtcgg gaataccggg gactgagcgc
     9061 gggttgcccc gcacatgggc ggactacggg gtaggcgcgc ggccgacggc ctgatgccgc
     9121 tcgacgacgc gctcggcgcg ctgggcggcg acggcgtgat ggggcgccgg ttcgccgagg
     9181 tccccctcgg ccggatcgtc ggtacctccg cccgcgcctg cgacttcgac gccgagttca
     9241 agctggtcaa ccgccggctg cgcgaccggt ggcacggcgt cgcgaaggtg atggaatccg
     9301 gctccgagcc gccggtcgat ctcgtgcagc tcggtgagct gtacttcgtc gtggacggcc
     9361 accaccgggt gtccgtggcg cgggctcggg ggtggccggt cgtgcccgca caggtggtac
     9421 aaatctgcac cattgcttac gcgatgggct gcctccggct ggcgcacctg ccgagcaagg
     9481 cggccgagcg ccggttcctc gaccgggtgc cgctgcccgc cgacgtgcgc gcggacctct
     9541 ggctcgacga acccgcggac tggtcccggc tcgccgacgc ggccgagtcg tgggcgttcc
     9601 ggcgtgcgct cgacggcagg cccttcaccg accgcgagga gttggccggg gtctggtggc
     9661 gcgacgaggt gctcccggtg atcacgcgcc tgcgcgacgc cgggaagtgc gtcgatctcc
     9721 gcgacgtcga aacctacgcc gtcgcgctcg cgacgcggga tcaccacggc tggcacgtgt
     9781 ggccggaaga cctccccgag cgcgtgggcg cacctgctcg gcagggagtg cggcgactgg
     9841 gccggtaggg cgaatcagcc cttctcgatc gggtaaaacc ccttcgcggg ccttggctgc
     9901 ccgcgaactc cttggttgcc tgcctgaggg tgggaaaacg caggcgaccc gagggaaggc
     9961 gtgatccgct gtgcagccgt tcgagctacc caagttctac atgccctacc ccgcacggct
    10021 gaacccgaac ctcgaacgcg cgcggcaaaa cagcaagtcg tgggcgtacg cgatggatat
    10081 gatcgacgtc ccgcagcacg gcaccgcgat ctgggacgag cacgacctcg actcccacga
    10141 ctacgccctg ctgtgctcct acacccatcc cgactgctcc ggccccgtcc tcgatctgat
    10201 caccgagtgg tacgtgtggg tgttctactt cgacgaccat ttcgtggagc tgtacaagcg
    10261 caccccggat ctccagggcg cgcgggccta tctcgaccgg ctgccgtcgt tcatgccggt
    10321 ggacggtgaa atcaccgcgg tgccggagaa cccggtcgaa aagggcttgg cggacctgtg
    10381 gtcgcgcacg gtgcccgccc gctcggcctg ctggcggcgc cgcttcgccg aaagcaccaa
    10441 gaacctgctc gacgaatcgc tgtgggaact ggggaacatc agcgaaaacc ggctggcgaa
    10501 cccgatcgaa tacatcgaga tgcggcgcaa ggtcggcggc gcgccgtggt cggcgaacct
    10561 cgtcgagcac gcggtggacg ccgaggtgcc cgcggcgatc gcggcgacgc ggccgatgca
    10621 cgtcgtgcgc gacaccttcg ccgacgccat ccacctgcgc aacgacctgt tctcctacga
    10681 acgcgaagtg ctggacgagg gcgagctgag caacggcgtg ctggtgctgg agcgcttcct
    10741 cggcatcggc acccaggagg ccgcggacgc ggtcaacgat ctgctgacct cgcggctgca
    10801 ccagttcgag cacaccgcgc tgaccgagct gccgccgttg gtcgaagagc acgcgctcga
    10861 tccggtgcag cgcatgggcg tgttcgccta tctcaagggc ctgcaggact ggcaggcggg
    10921 cgggcacgaa tggcacctgc ggtcgagccg gtacatgaac ggctcgaccg aggaatcccg
    10981 tgccgcgcaa ccggttctgg gcgggccgag cgggatcggc acctccgcgg cgaggatctc
    11041 gtcctcgatc gcgggcaccc tcccgcagcg ggcgcgctcg ttcagccacg tcccgttcga
    11101 aaaggtcggt ccctccccga tcccggactt ctaccagccc tacgagctgc gcatgagccc
    11161 gcacctggac accgcgcgcg agaacgtcgt cgaatgggcg aaaaacgtcg gcatcctcga
    11221 cgaagcggtg tgggacgaag agaagctgcg cgcctacgac gtcgcactgt gcggtgccgg
    11281 gatccatccc gacgcctccc ccgaggaact ggacctgacc tccgcctggc tcgcctgggg
    11341 gtcctacgcg gacgactact accccgccgt cttcgggcgg acgccggacc cggccgccgc
    11401 gaaggtgtgc acggcacggc tgtcggagct gatgccggtc gacgggccgc cgaagacggc
    11461 gccggtcacc gggctcgaac gcgggctggc cgagatctgg gcgcgcaccg cggccccgat
    11521 ggacgtcccg gcgcggcggg cgttccggcg cgccgtcgag gagatgctcg cgagctggct
    11581 gtgggagctg gcgaaccacc gggcgaaccg gatccccgac ccggtggact acatcgagat
    11641 gcgccgcaag accttcggtt ccagtctcac gatgggcctt tctcggatcg ggcacggcag
    11701 gacggtgcca ccggagctct accgaaccag gccggtccag aacctcgaga actccgcgat
    11761 ggactacgcg gcactgctca acgacgtgtt ctcgtaccag aaggagatcg agtacgaggg
    11821 cgagctgcac aacggcgtgc tggtggtgcg gaacttcctc gactgcacac cggatcgcgc
    11881 gctcgccgtg gtcaacgacc tgatgacagc gcggatgaag cagttccagc acgtcgtcga
    11941 gctggaactg cccgcgctgg ccgaggacca cgacctcggc cacgacgtcc gcgccacgct
    12001 gatcgggtac gtcgaggagc tgaagagctg gatttccggc ctcctcaact ggcaccgggg
    12061 ctgccaccgg tacgccgagg aagacctgcg gcggaacttc ggccgcgacc gggcgccggc
    12121 ggcggggtcg ctcaccggcc tcggcaccgc ggcggcgagg atcggcagga caccggtgcg
    12181 ggccggggcg ggcgcggggt gacaatgacg gggtggacgc ctaccccgtc gccgatctcg
    12241 tcggctacct gagcggacgg tggcgcctgg accgggagat cgtggccgcc tcgggcgagc
    12301 cgctcgggcg gttcggcggc acctgcgctt tcgacgccga cggcgaggag ctcgtgcagc
    12361 gggagcgcgg cgtgctcgac ttcggcgcgc accacggcga ggccacccgc gaactgcggt
    12421 tccggctgac cggccccggt agcgccgacg tccacttcga ccacggcggg ttcttccaca
    12481 ccgtcgatct gacctcgggc agctggctgg cgagccatcc ctgcgcggag gacctctacc
    12541 gcgtcgagta ccgcgtgctc ggcgcggacc actggcgtca cgagtggacg gtccgcgggc
    12601 cgtcgaagga ccacgtgatc ttctcggcgt tccggcgcga tcagggcttg ccgagcaccg
    12661 ggtaggcgcg caggcagtcc tccagctcgt cgagtaccgg cggcaggtgc gtctggtcga
    12721 gcccgccgag ttcgaaccgc agctggtttc cgtgccccgc ctggtcgagc agggtgcccg
    12781 cgaccgcgag cacaccgctc ggctcgcacc gcacggtcag cttcacccag tcctccatgc
    12841 tgtcgaggac cgcggcaccg ctgagggttt cgtacagcgc gctcagctcg cggtgaaagc
    12901 tttccagctc ggacgtccgc agcgtcgcgc cgacggtgcc ctggaacccg ccggcgtgga
    12961 tcgcgatcgg cgacagcagc cagttgccgt cccagtagtc gtccgcaccg ggatgcgctc
    13021 tgcccagcag cgcgatcgag aggtggtccc catgcgggtt cccgagcagg acccggtggt
    13081 gcgcgccttc ggtgctcatc gggatcagca taggtgccgc acggcgaatc cgggagcggc
    13141 gaaccgctcc cggatctcgt cagtccactg tggacagcgt cagtagtcct tgagcaccag
    13201 cgcgccgacc acgccgtcga agtcctccgg ctcggtggtg atctcgacgg gctcggccgc
    13261 ctcggcaccg cccatggccg ccctggtctg cgcctcgacc ctggcccggt tggtcagcgc
    13321 gagccgctgg ttcgccgcga cgtagtcgcg gatttccgtt tcgtagcaag cgaaggcggt
    13381 ttcgtggtcg ccctcggccg ccttcagctc gcccgccagc acgtaggcgc cgacgagcgc
    13441 catgctggtg ccctgccccg acatcggcga gccgcagtag cccgcgtccc cgatcagcac
    13501 caccctgccg cgcgaccacc ggtcgaggtg gatctggctc atcgagtcga agctgaagtc
    13561 cggggcgtcc cagctgtagg tgagcgcctt cgggaactcc caccccgcgc cttcgaggcg
    13621 ttcggccagt atccgcttct gctggtcgat gtcgcggtag tcgtactcga ccggctccgg
    13681 ggattcgaag ccgacgtaga cccggcactc ggtggtgtcc cgcgcgctca tcatcccgcc
    13741 gccgaccgcg cccgcctggc agaacacctg ccagtggtcg aggccgagga agttcggcgc
    13801 ggtgtacacg gcgaggtagg tgccgaggtg cgagatgtag tcccgctccg gtccgaacgc
    13861 cagcgaacgc accgtcgaat gcaggccgtc cgcgccgacg acgaggtcga atcggcgcgg
    13921 cgcggccttc tcgaaggtca cgtgcacgcc gtcggcgtcc tcggccaggc tcgcgatcga
    13981 gtcaccggtg aggtactcga cctcgtcgcc ggcggcctcc tgcagcagga gcgcgagatc
    14041 gtcgcgcatg atctcgatgt cggcgttcgc gagatcgccg ccggtgaagg tgtgctcggt
    14101 ggagctgtac agctcggcgc cgctctcgtc gaccatcgtc atcccgcgca tccgggtgct
    14161 ccgggcgcgg accgcgtcgg cgatgcccat ccgctcgatc acctcgagcg cggggccccg
    14221 cacgtcgacg gcctggccgc cggggcgcat ccggccctcg gcacgctcca cgatcgtgac
    14281 cgagcagccg tagcgaacca gccagtaagc cagcgcgggc cccgcgatgc tggcgccgga
    14341 gatgaggacg gtggtgttct tcatcggtgt ctcccgaggt cgtggccggt gaccgtggtt
    14401 ccggcccggt gttgaccccg actctgtccg gccgcgctgg ccgtcggctg accgcgggct
    14461 taccggccgc ggtcagcacc ccggtaagcc cccggtcctc aaggtttggc cgccaccgga
    14521 tcccgtcccg cggacaggtt cttgatcgcg gcgagcaact cgtcgacttt gccttcgacc
    14581 ttctgcaacc gggtgtacat gtccgccgag gcgccaccgg cggtgaccgt gccggtcgtg
    14641 tcccagactt tgccgaggtc gtcgttgatc gcgttcacgg tggggtagac cgcacgcgcc
    14701 ccggagccgc ctccgccgta gaacgcaccg aggtacaggt tcgccagtgc gtcgccgatg
    14761 gtgatgtcgg agccgtccgg ccgtttgccg atgacgtcgt tcgcggacat gtcgtcacct
    14821 ttcgtgatcg ggatgagcag gtcgttgatg tcgcactgga tgccgccgac gctggcggcc
    14881 ccggtgttgc gctggtagac gtgcacgccg ggccggacgg ccgagcggga accgcactgc
    14941 cagaagtacg cggcgcggcc gccgtccctc gcggggttga tgaactcgga gaacccgtat
    15001 gcgccaaccc tttcccggcc gagcaccgac gcggcaccgt cgagataggt cagcgctgtc
    15061 gccacctcgc cgggtgcgag gtggcggtcc gcgcagaaga agatcgggcc gttcgcgtac
    15121 ccgatcgcgg cggcgtccgc tcgcgcggca ttcgccgcgg ccaccccgcc ccggaaacca
    15181 cccatggcgt cgtcgacgcc gttctcgtag acgagccaca cgctgacgcc gttggccacg
    15241 aggtccgcgt actcggccgc cttgatgttc ttggcgcgac cgggtgtacc ggcgtaccgg
    15301 atgacgaacg aatgaccggc atcacgaata gcccggcccg ggatccggcc ggcgctgtag
    15361 tcaagaccgg ttgtcatgac atcactcctc agattgggcg cagactgaag aagccctcac
    15421 ccaggttgac ggagcggcgg cggcgatcgc aggtgctgcg gtacgtccta tggggctacc
    15481 gcactagccc gatcgggcgg accgatcagc cgccgcgtgc cggtgcccga gcacgggctg
    15541 tccccctttc ccgccgcgga atccgcgatc ccacggccaa tgcccccggt cgtccgcgta
    15601 cacgagctgt acggcgcgga ccccgccgcc gtacagctcg atggccgtga acagatgcgc
    15661 cgagggttcg gtgacctcga cgatttcgat gagggggccg ccgcggagcg ggatctgctc
    15721 gccggcggtg ggcgcgtcgg cgtgcagcac gtgcgcggcc accgagttga gcagcgcccc
    15781 tgcctttccc ggcggcagcc cggtcaccac gagctccggt ctgccgcgtg gagtcagccc
    15841 gaccgtgtac gcccgtggcg ggtgcagcct gtcgcgctcg atgctctgca ccgcccagcc
    15901 gcactcggtg atggtcccgc gcagctcatc gaggtagtcg agcctgctgc cgcctggctg
    15961 atcacatttc cagcacatcg ttcctcctcg cggatcgtga acacccgacc actatgcgga
    16021 ggggcaccga cagaaacggg gagatgcggt gtcgcgtggg cggaggatgc aggattcgaa
    16081 cctgcgcggc gctcgtcgcg ccgaccaccg ttttcgagac ggctgcctta cctggctcgg
    16141 ccaatcctcc ttgtgccgca acggatcccg cgcggagggc gcgcgattcg aacgcgcgcc
    16201 gggacgagaa gtcccggacc tcggatcagc aatccggtgc cttgcctgac tcggccagcc
    16261 ctcccgtgct gcccgccgac tgacgggcag caggtggtgt tgttcccccg ccaggattcg
    16321 aacctggact ggacgcgttc tgagcgcgtt gcctctgccg ttgggctaca ggggagctgg
    16381 caccgccgtg aggaaggcgc cgggccagga acgagtgcgg ttccggggag tcgaaccccg
    16441 actgtgctgg ctctcgacca gctgcctctg ccagttgggc tagaaccgcg cgacggggtg
    16501 gctgaccccg gtcggatgcc cgcgagtcga acgcggtgac tcctgatccc aaatcaggcg
    16561 gggtcgccga tgcccctcgc acccgtcagc gcccctgcca ggactcgaac ctgggacctc
    16621 cgcattcgta gtgcggcgct ctgttcccgc tgagctacaa gggcttgcgt ggtgaaggag
    16681 ggagtcgaac ccactgtgcc ccgtccgggg cgtccggttt acagccggat ggggctccac
    16741 agccccggct ccaccgtgcg tcgagatggt tctccgccgc gcccctgtcc aagaaccgcg
    16801 cgacagaaac gaaatgggcg acaagaacac gaactcgaaa aactgtcaca gaattgaatt
    16861 tgcgccgtca gcggacactg aacagagaaa gccgcccgga tcggttaccc gatgggcggc
    16921 tccctcgacc gaacggttcg tccgtcacgg cggggagccc gcacagctca gaagtccttg
    16981 ccccggatag gaaacaagca ggtgacgacc aggtgacgac catgcggcag cgagccgcac
    17041 cccgcgcttt cccgagttcg ccatgtccgc tccttcgatt gaccgtgcat tcatcatggc
    17101 ccgccggagc gaatgcgtca atcctatttg aaaaccggcg gaaacgggct cgggcgggac
    17161 cgccaacccc agggacggtc ccgcccggac gcggcaggac ccgccccgcg atgggagtag
    17221 caggacgggt ccggccggcc cgtccgcaac gggggaatgc ctgccgggcg cgcgcggacg
    17281 agcacgacac ccaacctaga tcgcccgctc aggcgcgtct tctccaatgt tgcgcgatgt
    17341 cggaggccag cgcgggcaac gcggccagca ccggcggctg ccagcgttcg accggttcga
    17401 gcgcgatatc gcagaggtgc cgttcgccgg ggcgcatccg cagcatgcgc ggggacgtgc
    17461 cgatcaccga ctcccccggc acgaggagcc cgtcgtagtc gccgcgcgtc gacaacgcgg
    17521 tggcgagcac ccagaacagg ccggggggaa cgtcgatcag caggaactca ccgggtccgg
    17581 cgagcatcgc gcccgcgacg ggctgcccgc gcgccgaccg tgccgggtac aggccgacga
    17641 acaccagcgg atcagggccg agcaccgccg cggcggacgg gccgatccgc accgaaccgg
    17701 cgacgccccc gccgccgcgc gcctcgcccg aggtcgagac cgggcgcggc ggcgcgtccg
    17761 cgagatcgtg cgggagccgc cggaactcgg tgggactcgt tcccaccgcc tcggcgaagc
    17821 gggtggtgaa ggtgccgacg gaggagaaac cgacggcgtg gcagatatcg gcgatccggt
    17881 cgtcgccgtc gagcaggagc cgtttcgcgc ggtggaagcg gtgggcggcg agcacccgca
    17941 ccggggacgt gccgagttcc ctggtgaacg cccgcgccag gtggaacggg ctgtagccga
    18001 cgtgatccgc gacgtcgccg agccggatcg gttcgccgga gtgcgcgtgc aggaacaccg
    18061 ccgcggcgat gacggcatcg cgcactgttg ctccctcccc agggtcgacg aaacccatcg
    18121 tgccgcaccg cgcgcgcccc cgtccattcc ggccgggttg acctcaagac gcctcgagac
    18181 ggcgcccgtg agccggtcgg ctacgcggtc cgaggagtac acaatggaca cagaagtgct
    18241 cgtggtcggc gcgggtccgg ccgggctgtt cctcaccacc gtgcggacgc gagcgcgcgc
    18301 tcgaactctt ccgctcggcg ggccccggcg aagcagccct cgtgcgcccg gacggcttcg
    18361 tcgcctggcg cggggaaagc ggcgggctgc acgacgcgat gcacgcgatc ctgcggcccg
    18421 cgtagcctcg ggacgtgagt gaagaacccg agtaccgcca gcaccgtttc agcccgccgc
    18481 cgggagccac cgagatcttc ctggtgcgcc acggcgaatc cgcccccgcc cgcgcctcgg
    18541 cgcccttccc gatggtggag ggccaggccg acccggacct cgccccggag gggcgtgagc
    18601 acgccgagcg cgtgggagaa cggctcgcga acgagcggct cgacgccctc tacgtcacga
    18661 cgttgcggcg caccgcgcag acggcggcgc cgctcgcggc gaagctgggc atcgagccgg
    18721 tggtcacccc gctgctgcgc gaagtccacc tcggcgagtg ggagggcggg ctgttccgcc
    18781 gcaacaccgc cgaggggcat ccggtggcgc ggcggctctg ggccgaacag cgctggggcg
    18841 tgattccggg cgcggaggac gtggccgcgt tcgccgcgcg cgtcaaggcg ggtctcaccg
    18901 aagtggcggc ggcgcatccc gatcagcggg tcgcggtgtt cacccacggc ggcgtgatcg
    18961 gggaggcgat ggcgcaggcg agcggctcgg agccgttcgc gttcctcggc gcggacaacg
    19021 gctccatcac gcatctcgtg ctcacggccg acaattggct cgtgcgccgg ttcaacgaca
    19081 ccgcgcacct ggccgcgccg ctcggctgag cccgcccgcg gccaccagct gcacggtcac
    19141 cagcaccgag acggcctcgg ccgcgagcag cccgatcagc acgagcagct gggtgacgcc
    19201 tgcctgcacc ggcccggcgc cacccagcag cacgccgacg taggcccctg gcagcgtcac
    19261 caagcccacc gtcctcgtct ggtcgagcgc ggggatcagc gcctggctcg ccgacgggcg
    19321 gcagatctcg agcgcggcga ggcggggcgt gaaccctagc gccagcgcgg cctcgtattc
    19381 accgtgccgc gtctccagct cgtcgagggc gcgccgccct gcctgcgagg tcgccgacat
    19441 ggcacccccg atgacgatcc cggcgatcgg caccaccgcg accggacgca gcggcagcac
    19501 gcccgccgcg agcaccaccg ccagtaccgg caccaccccg gcgccgatcg cgacggcggt
    19561 ccagccgaag ccgggaccgc gccggggcac cccgatccgc cgcgccgagg tcaccgccgc
    19621 gacggcgaac atcaggagca cgaacagcgc ggtccaccag cccgagcgca ggaccgcgac
    19681 gatcaccagc gagacggcgg cgagctggac ggccgcgcgc accgccgcgg acacgatcgc
    19741 ccgtccgcgg ccgagtccac cgagccacag caccgccgcg ccgagcgcga cgaacagcac
    19801 gagcacggca ccgagcgcgg gcccaacgac tatcgccccg ttcgtcaccc cggggattct
    19861 ggctcagtcg agcaccttcg cgcacatcac gacgccgtag tcggtcgccg tgctccgctc
    19921 gctgaccacc ttgccgtcga cgagaatgcg gcagcgcagg gtgccgtggc cgccgttctg
    19981 cgcggacacc gtgacgtagt gcggcccgtt ttcgggatcc gcgcgcgaca ccgtctgggt
    20041 ccacggcgtg gggaccccgt tgagctgctg gacgtcggcg cccttggcga cgaacgtgac
    20101 gtggacggcg ccgctgtcgc ccgccagttc gtaggtgacg tccctggtcc ggaccacggc
    20161 gccgtgggcc tccggtgccg aagtcagcac cgggagcgcg ggcagcgcgt gcgcgcccgg
    20221 cgtcgcggag ccgccaccgc cctggtcccg gttcgccgcg accagcaccg agaccacgac
    20281 gatcccgagt accgcgagcg aacaggcgag cagcacgccc gagcccgatt tgggccgccg
    20341 tgcgcggctc gtagtgaaga ccccccgtgg atgctctgcc atcggcggcc gactcccctc
    20401 gtcacgctcg gctatcgaac gcgtcgatta gttctcgccc gaacgtatga caccgttacc
    20461 gctgttgaac gcgattaatc gagtttcacc cgatcggctc acgccgagtg cggggaatac
    20521 cggctagtag caaggctttc cgcgatccgg ccaccagcgt tcccgcgatt ttccggccgg
    20581 accccgcgaa gaaccgcgca cacggcacgt gatcggcgtt cagccgatca ggccagcgtc
    20641 gccgagcatc gcgagcacct tcctgcccgc gggcgggcag agcgcggcgt cggccgtggt
    20701 gagccagcgg tgctcggcga tctcgcgcga cggcgccagc tccccgcggt gctccgcggt
    20761 gaagcacgtc atccgcacct cgcggccgtc ggcgtacccg tcggcgcgct ccctcagcgc
    20821 ggtgaagaac gaaaaactca tcgggtccag ttcgacgccg agctcctcgc ggatctcgcg
    20881 gcacagcgcg gcgacgtcgc tctcgccggg ctcgcgtttc ccgccgggca ggtagaactt
    20941 gtcctttccc ttggtgcgca cggaaagcag ggcgcgatct cggacgagga tccaggcgag
    21001 gctgtcgacg aacggcggtg tcacgcgatc accgtatcgc cgtcattcgc tggtgtcgtc
    21061 gatgtccccg acgtcgaccg agagcacacc gctctcctcg gaaagcgtgc tcaccagcac
    21121 ggtgaacgtc ttcggcggcc cgtgcagccg catccggagg tcgatcacct gcgcggtgcg
    21181 caccttcatc ctgccctctt cgtcgtcctc gtccatctgg cgccgttcgg tgtgcacctg
    21241 ctcgacgacg tatccggcgt tcgtcgcgac ttcgaggatg ccccgcagcg cgccctcccc
    21301 gtcgcgatag ctgacccgca cgacctcgct cgcgggcctc gacctggtga acgccctgat
    21361 cagcggcggg tagccgtaga cgaccaggaa gtgcgccgcg gtgacgaacg ccgcgagcag
    21421 cggcagcccc gccgcgcagg cgcacccgac cgcgacgctc acccacacca cggccgccgt
    21481 ggtcagcccg cgcaccacgt cccggcggac gaagatcagc ccgccgccga tgaacccgat
    21541 cccggagacg atctgcgccg cgacccgcga ggggtcgagc acgatccggc cctgttccag
    21601 cacgtcggtg aagccgtact tgctgaccag gaagaacagc gccgcgccga gcccgaccag
    21661 ggtgtgcgtc cgcagcccgg cgctcttctg cttcagctcg cgttcgagtc cgatcaggga
    21721 gcacagcacg agcgcgatca gcagttcgac gacctgcgtc cagccctgtc cggacggctc
    21781 cccgagtgaa aacgcgagcg tcatggcctg gcggctccct tcgtgacgac gacccctcag
    21841 tgtctcctcc cgcgaggcat actcgcagtg tgtaccgcga agccccgcca ccgacccacc
    21901 tcgccggggc cgtgcggtgc gtgtggcatt cgacaccgga cgaccgcgag cgcgcgaaga
    21961 acgtcgtgcc ggacggctgc ctcgacctga tcgtgggcgg cggccgggtg ttcgtcgccg
    22021 ggccggacac ccgtgcgtgg cgaccgtcgg ccggtgggcg gagcgcgctg cacggcatcc
    22081 ggttcgcccc cggtcatgcg ccgctggtcc tcggcgtcgc cgcggacgaa ctgctcgacc
    22141 agcgggtggc gctgagcgag ctgtgggggc gggaaggcgc gcgtgcggcg gagcgcctgc
    22201 tc
//
