LOCUS       NZ_CP059997            29746 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 217484
            Orig. end                         :: 247230
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..29746
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NI-siderophore"
                     /region_number="3"
                     /rules="IucA_IucC"
                     /tool="antismash"
     cand_cluster    1..29746
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="IucA_IucC"
                     /kind="single"
                     /product="NI-siderophore"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..29746
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[14000:15746](-)"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(14001..15746)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="IucA_IucC"
                     /neighbourhood="14000"
                     /product="NI-siderophore"
                     /protocluster_number="1"
     gene            complement(573..1025)
                     /locus_tag="HUW46_RS00975"
                     /old_locus_tag="HUW46_00196"
     CDS             complement(573..1025)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016334902.1"
                     /locus_tag="HUW46_RS00975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00196"
                     /product="DUF488 domain-containing protein"
                     /protein_id="WP_215545452.1"
                     /transl_table=11
                     /translation="MGISATRLRDGVIGVGYEGQEIQSFVDDLVRHGVTRLVDVRLTPI
                     SRKRGFSKTALGGALAEAGIVYDHRRELGNLKANRAGFAGSETELAQAKARYAELLDNE
                     EAQASLDELGRLAATECIAVLCFEADQRRCHRDVVLGEIASRLSRS"
     gene            complement(1038..1244)
                     /locus_tag="HUW46_RS00980"
                     /old_locus_tag="HUW46_00197"
     CDS             complement(1038..1244)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS00980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00197"
                     /product="hypothetical protein"
                     /protein_id="WP_215545453.1"
                     /transl_table=11
                     /translation="MIPLWLVALVLLGPAVGYGPFLGLLAYVNKRRRQREIRRQAALRR
                     NGKITVEELYVREEGDLAGETSP"
     gene            complement(1345..1755)
                     /locus_tag="HUW46_RS00985"
                     /old_locus_tag="HUW46_00198"
     CDS             complement(1345..1755)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013677.4"
                     /locus_tag="HUW46_RS00985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00198"
                     /product="hypothetical protein"
                     /protein_id="WP_254125677.1"
                     /transl_table=11
                     /translation="MIDSGRTIAEVSRELGIDAGMLSVWVKDERRRVTAAEVHGDKPLE
                     AAERAELLRLRGQVTELEESMGALKGEQSWMRAGANAGASVVGGALGGAVVGAVAGSAF
                     TPVGSLILGVMGGFGGAKFASDIVEGFSQKIG"
     gene            complement(1752..2714)
                     /locus_tag="HUW46_RS00990"
                     /old_locus_tag="HUW46_00199"
     CDS             complement(1752..2714)
                     /NRPS_PKS="Domain: Abhydrolase_1 (31-155). E-value:
                     1.5e-16. Score: 52.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00990_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="HUW46_RS00990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00199"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_215545455.1"
                     /sec_met_domain="PF00561 (E-value: 9.8e-11, bitscore: 40.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.7e-13, bitscore:
                     49.7, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 2e-07, bitscore:
                     29.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPISTAETTFRTLDGLQLSGTVFATEPPAAHAVVLVHGGGVTREE
                     GGFFGRLVEGLGEAGLASLRFDQRGHGVSDGTQEERTLAEHLNDITSAIEHLRGVTGAR
                     TISLLGTSFGGGLAAYYAARAGAELQRLVLLNPQLNYLDRYVDQKPHWVDRHLDDTAAQ
                     QLRERGYLDHSDTVKHSRAFLNEVFWIRPNEVIGEIARPTLIVHGTQDTFVSIESSRKA
                     AAQLRVEHELVEIDGAQHGFAVDKDPEYLNPQSQQWQAFVIETVTNWLTCGLNPPMRFT
                     PGSGHRVSRISRSAERMSSCLLASTGRTRRSTRSRLLTA"
     aSDomain        complement(2250..2621)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00990_Abhydrolase_1.1"
                     /evalue="1.50E-16"
                     /label="HUW46_RS00990_Abhydrolase_1.1"
                     /locus_tag="HUW46_RS00990"
                     /protein_end="155"
                     /protein_start="31"
                     /score="52.7"
                     /tool="antismash"
                     /translation="AVVLVHGGGVTREEGGFFGRLVEGLGEAGLASLRFDQRGHGVSDG
                     TQEERTLAEHLNDITSAIEHLRGVTGARTISLLGTSFGGGLAAYYAARAGAELQRLVLL
                     NPQLNYLDRYVDQKPHWVDR"
     tRNA            3003..3076
                     /anticodon=(pos:220521..220523,aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="HUW46_RS00995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="HUW46_00200"
                     /product="tRNA-Pro"
     gene            3003..3076
                     /locus_tag="HUW46_RS00995"
                     /old_locus_tag="HUW46_00200"
     misc_feature    complement(3152..3164)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            complement(3276..4115)
                     /locus_tag="HUW46_RS01000"
                     /old_locus_tag="HUW46_00201"
     CDS             complement(3276..4115)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013229086.1"
                     /locus_tag="HUW46_RS01000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00201"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_215545456.1"
                     /transl_table=11
                     /translation="MNAVLVTGGTGKTGSALVELLRANGVPVRVASRHPSDRDPAAIRF
                     DWADPATHPAALHGVDRVFLVPPVESADPMPLVEPFLAEARRRGVRQVVLLGSAIVLPN
                     APSALELAAQVRAQPGWVVLRASGFMQNFLSPHPLGERIRRHGEIRTAAGDGRLGWIDA
                     RDIAAAAFALLTGPGDQQRDYLLTGPKALSYPDAAAIITAHTRRPVRVVRTEVDDQAAA
                     YRAAGIAADFAAALAAVEDGIRAGQDDQISTAVLDLTGRPPRTFAEFVQEHATAWSS"
     gene            complement(4112..4522)
                     /locus_tag="HUW46_RS01005"
                     /old_locus_tag="HUW46_00202"
     CDS             complement(4112..4522)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020667785.1"
                     /locus_tag="HUW46_RS01005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00202"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_215545457.1"
                     /transl_table=11
                     /translation="MLDLMLVKDTDAAADLWAEDGVAEFPFAVGTSPRLVTGRDAIRVY
                     LGRLPGVLDMREVPAITVHHMENPDTVVAEFSATGRTLCTGEPYRLDYIAVITVQDGLI
                     TRYRDYWNPLATASATGTLPELLDALGTEVAR"
     gene            4690..5508
                     /locus_tag="HUW46_RS01010"
                     /old_locus_tag="HUW46_00203"
     CDS             4690..5508
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020417842.1"
                     /locus_tag="HUW46_RS01010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00203"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_254125679.1"
                     /transl_table=11
                     /translation="MSRAELADFLRRRREALRPDQLPAAATQPGGRARRTPGLRREEVA
                     ALAGMSVSYYERLEQARARRPSPEVLAVLGTALQLTNAEREHLARLAGQIPASTGRRPV
                     PAEARGLLDRLGSIPAYLIDERQDIVAWNSAAAALIPRFELLPAEDRNTVRLAIRLGGT
                     FCRAPAGEEREFARQFAAQLRAASARYPADRVLGELVNELAAHSPEFAIGWRDHDVRPV
                     AALRKYLRHPELGELDVVCQTLLVPGTELQLAMYTAEPGSPSAAALARLA"
     misc_feature    complement(4706..4720)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            5527..5925
                     /locus_tag="HUW46_RS01015"
                     /old_locus_tag="HUW46_00204"
     CDS             5527..5925
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020669485.1"
                     /locus_tag="HUW46_RS01015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00204"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_215545459.1"
                     /transl_table=11
                     /translation="MASLDKIAWLRLADERVLGARSHGKDAFYLPGGKREPGETDVETL
                     VREIGEELAVAIDPASAVRFGVFEAQAHGKAAGVLVRMTCYTAEFSGSLTASGEIAELA
                     WLTYADRDRVSPITRLVFEHLRERGLLR"
     gene            6004..6987
                     /locus_tag="HUW46_RS01020"
                     /old_locus_tag="HUW46_00205"
     CDS             6004..6987
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010304796.1"
                     /locus_tag="HUW46_RS01020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00205"
                     /product="GlxA family transcriptional regulator"
                     /protein_id="WP_215545460.1"
                     /transl_table=11
                     /translation="MRTAAVLFLLFDGVQSLDVTGPLEVFTSANGWLLAHGGKPAYAIT
                     TASVGGAAVRTSSGLRITPDADLAEVAVPDLVVVPGGEGTWSPPPELTAWLRGTGPGVP
                     RLVSVCTGAFLLAEAGLLDGRRATTHWAYCDALAERYPDVLVSDEPIYVEDGPLATSAG
                     VTAGIDLALAIVEADVGREVALTIARYLVMFLRRPGNQAQFSTQLSAQVAEREPVREVQ
                     RWIAEHPDADLSVEALARMASLSPRQFARVFAAEVGVNPGRYVDRVRVEAARRLLEDTG
                     RGVEEVARDCGYGTPEAMRRAFLRVLDVSPAEYRRRFRPAHSRGES"
     gene            6987..7616
                     /locus_tag="HUW46_RS01025"
                     /old_locus_tag="HUW46_00206"
     CDS             6987..7616
                     /EC_number="4.2.1.-"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016699271.1"
                     /locus_tag="HUW46_RS01025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00206"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_215545461.1"
                     /transl_table=11
                     /translation="MRVAILLYDRFTTLDATGPYEVLGRVPGAEVVFTAERTGPVRNDL
                     GSLAIVADAALGEVESPDIVLVPGGPGQRELMTDGPVHDWLRAVDATSTWTTSVCTGSL
                     ILGAAGLLTGRKATSHWLALDQLPSFGAEPVSERVVVDGKYVTAAGVSAGIDMALTLAG
                     RIAGDEAAQRIQLLTEYAPAPPYDAGRPDTAPAEIVAGMRAQASRS"
     gene            7662..8300
                     /locus_tag="HUW46_RS01030"
                     /old_locus_tag="HUW46_00207"
     CDS             7662..8300
                     /EC_number="4.2.1.-"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020502017.1"
                     /locus_tag="HUW46_RS01030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00207"
                     /product="DJ-1/PfpI family protein"
                     /protein_id="WP_215545462.1"
                     /transl_table=11
                     /translation="MRVAILLYDRFTALDVVGPYEMLCRLPGAEVVFTAERTGPVRNDA
                     DSLTLVAEASLGEVEAPDIVLVPGGPDTRGPAGDGPVRDWLRAVDATTTWTTSVCTGSL
                     ILGAAGLLRGRRATSHWIALDRLPSFGAVPVSERVVTDGKYVTAAGVSAGIDMALTLAG
                     EIAGAEVAQRIQLGAEYAPEPPYDAGRPDTAPAEIVAGLRAMSAQILQG"
     gene            complement(8291..9487)
                     /locus_tag="HUW46_RS01035"
                     /old_locus_tag="HUW46_00208"
     CDS             complement(8291..9487)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS01035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00208"
                     /product="hypothetical protein"
                     /protein_id="WP_215545463.1"
                     /transl_table=11
                     /translation="MSTVPVSRASHGYRAVLRAPGMRAVFAAHAVSMAGTIAAEVALSI
                     LVFERTRSPLLSALVLACSFLPHAFGGTALSPIADRFPARGLLVCCDLLSAACVAAMLV
                     PGLPVVALLALLVVTSVLAPVFQGARAGSLAHLLDADLFPVGRSLLRAVSQSTVLAGFG
                     VGSALVATIGTACLLAADVASFLVSAVLIGLCTPSTPVPRRDGGSGGSGFRAVFARVPV
                     RRLLLLSWAAPAFSSVASGLAVAYTAQAGAPVAGSGALLAGYATGTVAGEIVVATLRPH
                     VRRRLLFPLLLLNQLPLAAFAFVPPVWCATALLVLSGTGSAFNQCVDPVVLAAADPAAR
                     GRLFTVQSGGLMAVQGAGIAVAGAVAALVAPATVIGTAGVLGTVGVLALARRAVSPQP"
     gene            9555..10532
                     /locus_tag="HUW46_RS01040"
                     /old_locus_tag="HUW46_00209"
     CDS             9555..10532
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039924.3"
                     /locus_tag="HUW46_RS01040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00209"
                     /product="DUF5937 family protein"
                     /protein_id="WP_215545464.1"
                     /transl_table=11
                     /translation="MTVIRFGESDAARCRFGISPLWETLSAVRVLHNHRHRPLYSPWVS
                     AKAGLAKGLDLDPVRAVQPRVGHTPDFLTPPPRTPRTEFAGELARVRATPPGRVAAELA
                     RTRDQPANPRAAEVDRMLADPAAARDRLADAVEAAWEALLEPDWPKIRRVLEDDIAHRG
                     QRLTEGGFGALFDDLHPTLRWEGTQLVASKYRDHDRDLGGAGLLLVPGVFAWPYLVAVV
                     APAYQPAVLYPARGAARLWTTAPPPPDRLARLLGRSRAAVLAALDPPSSTTELAGRYGL
                     APATVAEHLGALRDAGLADKRRHGHEVRYRRTELGQALVDAAVG"
     gene            complement(10679..11437)
                     /locus_tag="HUW46_RS01045"
                     /old_locus_tag="HUW46_00210"
     CDS             complement(10679..11437)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020666791.1"
                     /locus_tag="HUW46_RS01045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00210"
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_215545465.1"
                     /sec_met_domain="PCMT (E-value: 7.6e-07, bitscore: 28.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVFETTRPGDYLLRLARSGAGSAYKRLAASLLDIRPGDVVLDLG
                     CGPGADLAAFAEAAGEGGRVIGIDHDRVQLEKARATAPPRADVREGDIHALDLPDASAD
                     RAHTDRVLQHVADPVAVVAELRRVLRPGGVAVLAEPDWDTLAIDHPDLATARAYTRYVT
                     ERAVRNATVGRSLARYGADAGFEVRDVVPVTTVFRDVTAADQVLGLHRVTGRAVADGYL
                     TEEAARDWLAHLANRPFFGSATLHLVVLGG"
     gene            11517..12755
                     /locus_tag="HUW46_RS01050"
                     /old_locus_tag="HUW46_00211"
     CDS             11517..12755
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671967.1"
                     /locus_tag="HUW46_RS01050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00211"
                     /product="glycosyltransferase family 87 protein"
                     /protein_id="WP_215545466.1"
                     /transl_table=11
                     /translation="MRKYFWGVLALAAVGLYFSVRLLLDDLPNAHLDLEVYRYGVQAWW
                     HDQDMYGQLPPVANGAHLPFVYPPFSILILGPLAILPWTGAIAALYTINIICLAITLYL
                     VSRRVWAKLDRRGGIMVAAVATPIALFFEPVNDTFEFGQVSIIMMAVIAIDCLAGRTVW
                     PRGFGIGLCAAIKLTPAAFLLYFLVRKDYKAAITAGITWLAASAVGFGVDWTASIRYWF
                     QGGSAAAGVSGTAFKTNQTINAVLARTGMPEGAVKILWLFLAAALLVLVALAMRNSEPV
                     LALMANAGLGLLVSPTSWSHYFVWVVPTVLVMIGYLGKRWSAKSPAFAGWLVAGLATAA
                     VFYLAPFHSLPDTEFPVVTQDWTPKDQVLTASYVLVGVPLLIAYAIPRLRAKRAARPAP
                     VKPEAEPVDAASP"
     gene            complement(12715..14007)
                     /locus_tag="HUW46_RS01055"
                     /old_locus_tag="HUW46_00212"
     CDS             complement(12715..14007)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419973.1"
                     /locus_tag="HUW46_RS01055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00212"
                     /product="glutamine synthetase"
                     /protein_id="WP_254125681.1"
                     /transl_table=11
                     /translation="MVTSPRPLGPRALAERRPSSPPDGRLLLLVPDPHARFAAVELDAG
                     FVADEVREHGYGLCTYVFCWSPERTALSEVDESLRRYADRYGDLRLRPDFASLTALPDG
                     TSAVVCDAEWPSGEPVAAAPRQALAAQLRTLEELGFVPSVGIEHEVVFTGADGAPMTGH
                     GVDYALGGTEKLAPLLRELRSDVDGAGLGLESARAECHPGQYELVLRHRDALAACDDAM
                     LLQHLVRTAAARHGVEARYLAAPEPGQGSSCHVHLSLSTADGQAGMTGALGHFLGGVLR
                     DAAVLTPIWAPTWNSYVRLRTAPFSPIELRWGTDDRTAAVRLAGRGDSARLEFRFAGAD
                     AQPHLVVAALLASGRAGIEDGLAVPGEGTPAGALASTPWEALRAFTESTRPAELLGTEL
                     ASQQAALLSEELDSGLGAVTDWQRRRARLRA"
     gene            complement(14001..15746)
                     /locus_tag="HUW46_RS01060"
                     /old_locus_tag="HUW46_00213"
     CDS             complement(14001..15746)
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NI-siderophore: IucA_IucC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018687164.1"
                     /locus_tag="HUW46_RS01060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00213"
                     /product="IucA/IucC family protein"
                     /protein_id="WP_215549593.1"
                     /sec_met_domain="IucA_IucC (E-value: 2.7e-71, bitscore:
                     239.1, seeds: 168, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGELSYERLLDPEAAGEPGEDGHRPWRLVLPGDVRYEFRARRGA
                     FDSWCVAAGSATRAAGDDAPEPADDPRALLVDARAVLGLGGLRLADVLAELTATVTNEA
                     TRIAAAPTAARLSTMDYNLAEGYLTGHPRLVLNKGRVGFSAADRERYSPEAGADVVLRW
                     FAVHRDHARFRCVDGLSAEELLAEELDDEQRAEFTAVISDAGADPADYLWVPAHPWQAD
                     EIVGTLYAGELATGALIDLGPGWDHYRPHQTVRTLANVGRPQRRDVKTAVSVRNTLVYR
                     GLNSAATLAGPAITAWLKAIDAADPVLSREYRFELLGEVASVSVRHPVFGALEELPYRF
                     HETLGALWREPLLARVADGEQALSFAALPYRGPDGESVLAEVIGRSGLGAEDWCGRVFD
                     LLLTPLLRWLLRYGVGFCPHGQNLVLVVDSAGVPLRVAIKDFAQGVDLLDEDLDCYWSM
                     APEASAEMLRWPAHLLAQSLFSSVFSGQLRFWAEILLDELGLPRARFWALVREVVTRFR
                     DENPEEAARFDACRLFAPEVERVTLNREHLAGKGFDKVERDDEFDVRWGTVPNPLHAPD
                     PGGAW"
     gene            complement(15830..17110)
                     /locus_tag="HUW46_RS01065"
                     /old_locus_tag="HUW46_00214"
     CDS             complement(15830..17110)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1080: lysine/ornithine N-monooxygenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419975.1"
                     /locus_tag="HUW46_RS01065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00214"
                     /product="SidA/IucD/PvdA family monooxygenase"
                     /protein_id="WP_215545467.1"
                     /transl_table=11
                     /translation="MTPLDLAGIGIGPFNLSLAALAHPVTGLRAAFFDRRPEFRWHPGL
                     LLPGTTLQVPFLADLVSLADPTNPLSFLNYLREHRRLFPFYFAERFHIPRAEYDHYARW
                     ASERLPACEFGAEVRSVGWSGDAFELRFADRDPVLARSVVLGVGTVPHLPEPLRELASG
                     RDAPVVHSAGYLGARARLLASRRVLVVGSGQSGAEVFLDQLQHRSTVDGLGWLARTRAF
                     APMEYSKLGLEQFTPDYTTYFHGLGQRTRERLLPAQWQLYKGVDAETLSRIHGALYERG
                     IGGTWPKVTLMPGVEVFSARRTADGVELGVRHVQQGTETVLEADAVVAATGYRDTPLDE
                     LLAPLGVDFTVPLEVDRGYRLRLPEKIPGTVYVQNAERHTHGVGTPDLGLGAWRAASIV
                     NAVTGRTVYPLPDRTAFTTFGLPLEEQ"
     gene            complement(17107..18561)
                     /locus_tag="HUW46_RS01070"
                     /old_locus_tag="HUW46_00215"
     CDS             complement(17107..18561)
                     /GO_function="GO:0016830 - carbon-carbon lyase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016831 - carboxy-lyase activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019752 - carboxylic acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1180: Decarboxylase, pyridoxal-dependent"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419976.1"
                     /locus_tag="HUW46_RS01070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00215"
                     /product="pyridoxal-dependent decarboxylase"
                     /protein_id="WP_215545468.1"
                     /transl_table=11
                     /translation="MADSTPDAGSLAGGAAGHRRLAELIPVALRAFAEGTAERGGPAPA
                     GGPAAVAASLAADAPMLPREGVGAVRALDGLGRLLAAGSVDPAEPWCAAHLHCPPLAVA
                     VAADVVASAVNPSMDSWDQAPVASEIEREFTAGVAALCYPDAASPDAVVTTGGTESNLL
                     GLLLAREREPGVVPVCGRNAHHSVARAAWLLGLPAPLVVDCAGDRLPPGALDTALSGLP
                     GPAVVVATAGTTNTGEIDPLPAIAEVCGARGARLHIDAAYGGMALCSPRFRHLVDGLDR
                     ADSVALDLHKFGWQPISAGLFAAREGADLGALTVRAEYLNPADDTEAGLPDLLGRSIRT
                     SRRPDAFRMAVTLRALGTDGMGALVAHCVDTAAAVADAIGEHPALRLWGAPTLSTVLFR
                     PVAADELGDELVAGVRRALLEAGTAVVGRAALPPKEGGPERLWLKLTLLHPGVTPVDYA
                     PLLDLIAAAAASQETGIRAGQSTVGS"
     misc_feature    complement(18571..18589)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 26.57"
                     /tool="antismash"
     misc_feature    complement(18700..18715)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.5"
                     /tool="antismash"
     gene            18714..19352
                     /locus_tag="HUW46_RS01075"
                     /old_locus_tag="HUW46_00216"
     CDS             18714..19352
                     /NRPS_PKS="Domain: Polyketide_cyc2 (26-132). E-value:
                     2.3e-08. Score: 26.5. Matches aSDomain:
                     nrpspksdomains_HUW46_RS01075_Polyketide_cyc2.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019928.4"
                     /locus_tag="HUW46_RS01075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00216"
                     /product="SRPBCC family protein"
                     /protein_id="WP_215545469.1"
                     /transl_table=11
                     /translation="MIDLLGQLSEAHRELGTRGKARTVLLRRTYAATPEDVWDACTKPD
                     RIARWLGPVEGDLRLGGRYQIEGNAGGEILRCDAPKLLAVSWVFGENPATNTSEVAVTL
                     SPAPGGHTEFQLEHTGVDVDPEHWGKYGPGAVGIGWDLSLLGLAAHLGGEESAQDPEEL
                     LQTPGALEFMKRSGQAWGAAHEAAGVSHDEAKGAMERTIAAYTEAPPAE"
     misc_feature    18719..18733
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     aSDomain        18792..19109
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS01075_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.30E-08"
                     /label="HUW46_RS01075_Polyketide_cyc2.1"
                     /locus_tag="HUW46_RS01075"
                     /protein_end="132"
                     /protein_start="26"
                     /score="26.5"
                     /tool="antismash"
                     /translation="RRTYAATPEDVWDACTKPDRIARWLGPVEGDLRLGGRYQIEGNAG
                     GEILRCDAPKLLAVSWVFGENPATNTSEVAVTLSPAPGGHTEFQLEHTGVDVDPEHWGK
                     YG"
     gene            complement(19525..20478)
                     /locus_tag="HUW46_RS01080"
                     /old_locus_tag="HUW46_00217"
     CDS             complement(19525..20478)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070967 - coenzyme F420 binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658065.1"
                     /locus_tag="HUW46_RS01080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00217"
                     /product="LLM class F420-dependent oxidoreductase"
                     /protein_id="WP_215545470.1"
                     /transl_table=11
                     /translation="MARWGLTIPLTGVPLAAHRELIEQLPDLGYTDAWSAETAGTDAFS
                     PLLLASQWAPSLRLGTAIAPVYTRGPGLLAMSAATLAEAAPGRFVLGIGASSPVIVRNW
                     NAAEFADPFGRSRDTLRFLRAALAGEKVSEEYKTFSVSKFRLERPPDPPPSIMLAALRP
                     GMLRLAAKEADGAITNWLAPTDVPKIREVIGEDVELVARIFVCPTEDADAARGLGRMLI
                     SSYLTVPVYAKFHDWLGRGDALAPMHEAWAAGDRQRANTVIPDEVVDDLVVHGSPDECR
                     ERVQSYVDNGLDTPVISVLPTGGDPFDHVRGLAPRR"
     gene            complement(20517..22595)
                     /locus_tag="HUW46_RS01085"
                     /old_locus_tag="HUW46_00218"
     CDS             complement(20517..22595)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671960.1"
                     /locus_tag="HUW46_RS01085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00218"
                     /product="S9 family peptidase"
                     /protein_id="WP_215545471.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.1e-48, bitscore:
                     163.2, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 0.00014, bitscore: 20.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIDRDSFLRRQARTQRFTLGAPKNFQVAGDGSRVLFQRAESGTDP
                     RNSLWALDLATGVEKKLVDAAELLPGEEELPAEERARRERARETSGGVVGYAVDDASRI
                     AAFSLSGRLHTVDLVTGETAVLLDGATGAVDPRPNPTGTHVAYVRDRRLRVVELATGED
                     RELVTEDGEDVAWGLAEFIAAEEMSRARGYWWAPDGRSLLVERSDRAGVPKWTIADPAD
                     PAKEANVVAYPAAGEANVKVSLAFVGLDGKRTDVRAGDWEYVAAVHWSAGGNPLLAVQS
                     RDQRRMDVVEVDPADGSTRVLHTETDPQWIEIVTGVPAWTPDGRLVRVSSADGDYRLVL
                     DGEPVSPPGLQVRSVLNTGAQILFSGSEADPTQIHVYRTEPGGGVRRLSTTDGVHVGSG
                     SAAVTVLSSWSLAHSGPEVAVLRDGEPIAGIASHTVDPGLEPDPVLLTLGERGLRAALL
                     FPCGHRRGTKLPVLLDPYGGPHAQRVLRSRNAFLTPQWLADQGFAVLVADGRGTPGRGA
                     AWEREISGELASVTLADQVDALHAAAEQYPDLDLGRVAIRGWSYGGYLSALAVLRRPDV
                     FHAAVAGAPVTDWSLYDTHYTERYLGTPANNPEDYRRNSLIADAPGLERALLIVHGLAD
                     DNVFVAHSLRLSGALLAAGRPHTFLPLAGATHMTPQAEEVAENLMRVQIGWLHRELG"
     misc_feature    22604..22618
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.53"
                     /tool="antismash"
     gene            complement(22636..23457)
                     /locus_tag="HUW46_RS01090"
                     /old_locus_tag="HUW46_00219"
     CDS             complement(22636..23457)
                     /GO_component="GO:0005575 - cellular_component [Evidence
                     IEA]"
                     /GO_function="GO:0016776 - phosphotransferase activity,
                     phosphate group as acceptor [Evidence IEA]"
                     /GO_process="GO:0006797 - polyphosphate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007033496.1"
                     /locus_tag="HUW46_RS01090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00219"
                     /product="PPK2 family polyphosphate kinase"
                     /protein_id="WP_215545472.1"
                     /transl_table=11
                     /translation="MGKRAVRDALKAGETWPDPGSSPIGPEKKTKAQKKLTTTGERLDE
                     LQEALYAEGADGGGRSVLLVLQGMDTSGKGGTVGHVLGLVNPMGVRYAGFKAPTQAERR
                     HHYLWRVRKRLPDPGQIGVFDRSHYEDILVPRVEKLVPAGEWRRRYAEINAFEREVAES
                     GTTIVKVFLHISPEEQLRRLRARLTTPSKRWKYSSADLEARSKWDDYQRAYRDVLRRTS
                     TRHAPWYVVPADRKWYRNWAVARLLTETLAEMAPRFPQPDFDVDAELAKLG"
     misc_feature    complement(23485..23499)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.37"
                     /tool="antismash"
     gene            23651..24889
                     /gene="rocD"
                     /locus_tag="HUW46_RS01095"
                     /old_locus_tag="HUW46_00220"
     CDS             23651..24889
                     /EC_number="2.6.1.13"
                     /GO_function="GO:0004587 - ornithine aminotransferase
                     activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (37-358). E-value: 5.2e-103.
                     Score: 336.5. Matches aSDomain:
                     nrpspksdomains_HUW46_RS01095_Aminotran_3.1"
                     /codon_start=1
                     /gene="rocD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457568.1"
                     /locus_tag="HUW46_RS01095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00220"
                     /product="ornithine--oxo-acid transaminase"
                     /protein_id="WP_215545473.1"
                     /sec_met_domain="Aminotran_3 (E-value: 4.4e-117, bitscore:
                     390.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVYAEKVAEMPATSTDEFIALDEQWGAHNYHPLPVVIAEADGAW
                     VTDVDGNRYLDFLSGYSALNFGHRHPELIAAAQEQLGRVTLTSRAFHHDQMGLFCRELA
                     ELTGTEMVLPMNSGAEAVESAVKLARKWAYQVKGVPDGTAEIVVAGSNFHGRTTTIVSF
                     STDETARADFGPFTPGFVTVPYGDSAALAAAITDRTAAVLLEPIQGEAGVIVPPPGYLA
                     EARRLCDDAGALLIADEIQSGLARTGKLLALDHENVRADLYTLGKALGGGIMPVSAVVG
                     SRDVLGVLRPGEHGSTFGGNPLACAVGRAVIGLLKTGEFQQRSAELGERLHTRLGGLIG
                     NGLSAVRGRGLWAGIDIAPGGPTGREASRALAARGVLCKETHDNTLRIAPPLVISAEDL
                     DRGIDAVTEVVTR"
     aSDomain        23762..24724
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS01095_Aminotran_3.1"
                     /evalue="5.20E-103"
                     /label="HUW46_RS01095_Aminotran_3.1"
                     /locus_tag="HUW46_RS01095"
                     /protein_end="358"
                     /protein_start="37"
                     /score="336.5"
                     /tool="antismash"
                     /translation="IAEADGAWVTDVDGNRYLDFLSGYSALNFGHRHPELIAAAQEQLG
                     RVTLTSRAFHHDQMGLFCRELAELTGTEMVLPMNSGAEAVESAVKLARKWAYQVKGVPD
                     GTAEIVVAGSNFHGRTTTIVSFSTDETARADFGPFTPGFVTVPYGDSAALAAAITDRTA
                     AVLLEPIQGEAGVIVPPPGYLAEARRLCDDAGALLIADEIQSGLARTGKLLALDHENVR
                     ADLYTLGKALGGGIMPVSAVVGSRDVLGVLRPGEHGSTFGGNPLACAVGRAVIGLLKTG
                     EFQQRSAELGERLHTRLGGLIGNGLSAVRGRGLWAGIDIA"
     gene            complement(24981..25889)
                     /locus_tag="HUW46_RS01100"
                     /old_locus_tag="HUW46_00221"
     CDS             complement(24981..25889)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020645157.1"
                     /locus_tag="HUW46_RS01100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00221"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_215545474.1"
                     /sec_met_domain="DAO (E-value: 2.6e-39, bitscore: 134.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIGVVGGGVVGLTCALRLAEAGHTVTVLSADRVGDTTSSVAGGL
                     IYPPGTRPEDRCAGWTAAGVGEFTRLSEKDIGIRVLPGRLLHRAPAPWPYWAGAMPDLV
                     REDDVPEPWTNAVRFSTPVVHLARYLDWLSGAVAEAGVAVEHRRLASLAEVAGADLVVN
                     AAGLGGGALAGDSTVEPVGGQVVHLADPGLTEWVVDEDADVVTYVIPHGGHVVCGGTEE
                     RGRAGTEPDPEVAEDIVRRSRALVPELAGAEVLGTRVGLRPWRPEVRLDREGDVIHCYG
                     HGGAGVTLSWGCADEVAALAG"
     misc_feature    complement(25875..25890)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.75"
                     /tool="antismash"
     gene            25972..26616
                     /locus_tag="HUW46_RS01105"
                     /old_locus_tag="HUW46_00222"
     CDS             25972..26616
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005157105.1"
                     /locus_tag="HUW46_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00222"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_254125683.1"
                     /transl_table=11
                     /translation="MEQGTTEAAVAKTARGARPVAITSAVCALAMVALGIPFAGGTAPG
                     AVDRAFQDWVAGAFDGQAELLRLFVVATQPYVLVPVLAVVAIACALARRGPELAVALAG
                     PAIAIALNTWVLKPLFDRHNGGTYAYPSGHTVSLVSTLVVLVIVARPGAATALTAALGA
                     LLVPFAAVGMVGLGFHYLTDVVGGTLFAVAFVLAALLVSRAYFRRRPWPTR"
     gene            complement(26573..27616)
                     /gene="zapE"
                     /locus_tag="HUW46_RS01110"
                     /old_locus_tag="HUW46_00223"
     CDS             complement(26573..27616)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0051301 - cell division [Evidence IEA]"
                     /codon_start=1
                     /gene="zapE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224547.1"
                     /locus_tag="HUW46_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00223"
                     /product="cell division protein ZapE"
                     /protein_id="WP_215545475.1"
                     /transl_table=11
                     /translation="MSPAHLTDRRPEIGADELITALVPPPRFDTVRFSTYVPNPDEPSQ
                     AEAVRSCSAFAERVSAGVKEAKRSRFRSLFGSRDDTPAGPMGVYLDGGFGVGKTHLLAS
                     LWHAVPGPKAYGTFVELTHLVGALGFAEAVRRLSEHRLLAIDEFELDDPGDTMLVGRLL
                     RELMDAGVHIAATSNTLPEKLGEGRFAAEDFLREIQSLSSRFGVIRVDGPDYRHRGLPD
                     APPPATDDELTRSAEAHDGSTVDDFDALCAHLASLHPSRYGRLVDGVSRVHLRHVRPAP
                     DQMVALRLVAFADRIYDRAIPVMVSGVGLGELFGADMLEGGYRKKYLRATSRLTALARD
                     AAGSTPG"
     gene            27701..28459
                     /locus_tag="HUW46_RS01115"
                     /old_locus_tag="HUW46_00224"
     CDS             27701..28459
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1240: riboflavin biosynthesis protein RibD"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419988.1"
                     /locus_tag="HUW46_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00224"
                     /product="pyrimidine reductase family protein"
                     /protein_id="WP_254125684.1"
                     /transl_table=11
                     /translation="MQTLWPAPAGNPVDDDELERLYGYPDGLTRPWVQANFVSSADGAV
                     TVDDQSEGLSHPADKRIFLLGRDLADVVLVGGGTVRAEGYRGVRTNTTRRARRDRLGLS
                     PIPPIAVVTGSAGISPDSPLLTDTEVPPIIITTDAAAAERKRTLAAAGAEILVAGEQKV
                     DLTAALATLASRGLRRVDCEGGPHLLAELIAEDLVDQLCLTVAPLLAGGGAGRIAIGRT
                     STAPRSMELASVLLEDGFTMLRYRKPGPPA"
     gene            28465..29040
                     /locus_tag="HUW46_RS01120"
                     /old_locus_tag="HUW46_00225"
     CDS             28465..29040
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010694975.1"
                     /locus_tag="HUW46_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00225"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_215549596.1"
                     /transl_table=11
                     /translation="MSDEALLAKAVKGDQGAFDLLVRRHTPRMYRVALRITGSAAEAED
                     VVQDAWISAWRALAGFRGDAAVSTWLYRVVTNAALGQVRRRRPTVSLDAAMAPGDQGGS
                     GAAFEGAAFADTAANPEGKVVRAEQVEAVLRAIATLDVSQRVPLVLRELEGLSYEEVAD
                     VLEVSVPALRSRLHRARVALLAKLRELR"
     gene            29037..29483
                     /locus_tag="HUW46_RS01125"
                     /old_locus_tag="HUW46_00226"
     CDS             29037..29483
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224544.1"
                     /locus_tag="HUW46_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00226"
                     /product="hypothetical protein"
                     /protein_id="WP_215545477.1"
                     /transl_table=11
                     /translation="MTPAEETTEDPRNDPNWALVRAAAEAPVPTPPGLIARVLHSVHGL
                     RGRVFGAAVEFPSEQGTLRVSERVLVLLARRLAAGIGQEIGGVHVSAAALDEDGLQVLL
                     TVRYGVAAGEASAVLRARLHAALTDQLGGTAPPVTVHIVDVHPD"
     misc_feature    complement(29553..29570)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.95"
                     /tool="antismash"
ORIGIN
        1 gacaggatgc ccgccgcgag agctggcgac cactgatgcc gaccctgcac gtcgagaacc
       61 accttgccaa atggcagcac cgtcgaccgt ggctcgaccc cgccatcaac cctcaagtga
      121 cgatgtgccg cctgcaccgc ggcgccacaa tgaacagcca gtccctcgct ttgatcacgc
      181 cgaagcggat caccgggctg cgcataaccc ggcatcctgg ctggactgcc agccagcagg
      241 ccaagatcga cgcctacatg ggtcagctga ccctgttcgg caatgaggac cgcacgcctc
      301 tgcgcgcgcc gcgcttcacc gggacttacc actacgagtg cgaagaaccc ggctgccgcg
      361 gccacaagca gggcttcctc gactgggagt tcgtcgcgtt ccagattctc cgcctcggcg
      421 atctgaacga cgccactgcc cagcaagagc ttgagcagcg cttcctcaac gaactctgtg
      481 cgcctgaccg cgaagtcgcg ttctacgtcg gcaacgtcgc cgcccacccc gggacgttca
      541 gcgtcctcgg cgtctactac ccacccctca ggtcaggacc gcgatagccg gctggcgatc
      601 tcaccgagca ccacatcgcg gtgacagcga cgctgatcag cctcgaaaca caacacggcg
      661 atgcattccg tcgccgccaa acgccccaac tcgtccaacg acgcctgcgc ctcctcgttg
      721 tcgagcagct cagcgtaccg ggccttcgcc tgcgccagct ccgtctcgct tcccgcgaaa
      781 ccagcccggt tggctttgag attgcccagc tcacgacggt ggtcgtacac gatcccagcc
      841 tcagcaagcg cgccaccgag cgcggtcttg ctgaaacccc gcttccggga aatcggcgtc
      901 agcctgacgt ccaccagccg cgtcactcca tgtcgcacaa gatcatccac aaaggactgg
      961 atctcctgcc cttcgtagcc gacgccgatc acgccgtccc gaagccgcgt tgcgctgatg
     1021 cccatgccga taccctgtca tggcgacgtc tccccggcga gatcgccctc ttcacgcacg
     1081 tacagctcct cgacggtgat cttgccgttg cgtcgcagcg ctgcctggcg acggatctcg
     1141 cgctggcggc ggcgtttgtt cacgtaggcc agcaggccga ggaaaggtcc gtaaccgacc
     1201 gcgggcccaa gcagtaccag agcgaccagc cagagcggaa tcacggggtg tcccaatccg
     1261 tccgggtcgc atccggtgga agcgacaact cggcgtcgag cgctgcttgc ctggtcgcgt
     1321 cggcgggtgg ggtgtggtcg tcgtttagcc gatcttctga gagaagcctt ctacgatatc
     1381 gctggcgaac ttcgcgccgc cgaagccacc catcacaccc aagatcagag aaccgaccgg
     1441 agtgaacgca ctcccagcca ccgctccaac caccgcgccg ccgagtgctc cgccaacgac
     1501 cgaggcaccg gcattcgccc ccgcccgcat ccaactttgc tcgcccttca aggcgcccat
     1561 cgactcctct agctcggtca cctgtccgcg caagcgcaac agttcggccc gttcggcggc
     1621 ctccagaggt ttgtctccgt ggacctcggc cgcggtgacc cgtcgacgtt cgtctttgac
     1681 ccagacactc aacatgcccg cgtcgatacc cagctcgcgg gaaacctcag cgatcgtccg
     1741 gccggaatcg atcacgcggt gagcagcctc gaccttgtac tccgccgtgt acgaccggtg
     1801 cttgcgagga ggcatgagga catcctttca gcagaacgac tgatcctgct aactcggtgt
     1861 ccactccccg gggtgaacct cataggcggg ttcaggccgc aagtgagcca gttcgtgacg
     1921 gtctcgatga cgaacgcctg ccactgctgg ctctgcgggt tcaggtactc gggatccttg
     1981 tccacggcga aaccgtgctg agcaccgtcg atctcgacca gctcgtgctc gacccgcaac
     2041 tgcgctgccg ctttccggga cgattcgatg gagacgaacg tgtcctgcgt gccgtgcacg
     2101 atgagcgtcg ggcgagcgat ctcgccgatg acctcgttcg gccggatcca gaaaacttcg
     2161 ttcaggaacg cgcggctgtg tttcaccgtg tccgagtggt ccaaatagcc gcgttcgcgg
     2221 agctgctggg cagcggtgtc gtcgagatgg cggtcgaccc aatgaggctt ctggtcgacg
     2281 tagcgatcca ggtagttcag ctgcgggttg agcagcacca ggcgctggag ttccgctccc
     2341 gctcgcgcgg cgtagtaggc ggcgagaccg ccgccgaagc tggtccccag caagctgatg
     2401 gtcctcgcgc cggtgacgcc gcggaggtgc tcgatggcgg acgtgatgtc gttgaggtgc
     2461 tcggcgagcg tccgctcttc ctgggtgccg tcgctgactc cgtggccacg ctgatcgaaa
     2521 cggagagacg caagcccagc ctcgccgagc ccctcgacaa gacggccgaa gaacccgcct
     2581 tcctcccgag tgacaccacc gccatgcacc aagaccacgg cgtgagcggc cggtggctcg
     2641 gtcgcgaaca ccgtgcccga gagctggagg ccgtcgaggg tgcggaaagt ggtctcggca
     2701 gtgctgatgg gcacaatgcg ctcctcgggt cggaggcctc tttatcggcg gtggcgccgc
     2761 tggaggcgtg tcacaggtca acgacgactc catgttctcg ttcatcgtgt tcgcttgccg
     2821 atcgcggaac ccaacggagg tcggagggcg cccatgtgcg gcaccttccc gagacagcgg
     2881 cccgcagcgg gagttcgccg gggtcatttc cgcaggtcgg tggcaacagg cgacctgcct
     2941 gcgacgggcg ccgggtgacc agctaagctt tccccatcga acttcacgcg aggttcgagg
     3001 cccgggctgt ggcgcagttt ggtagcgcac ttgactgggg gtcaaggggt cgcaggttca
     3061 aatcctgtca gcccgaccgg gcaaaggctt cccgcaggtc attcactgcg ggaagccttt
     3121 tgatagtgct ccgggccaag cggttcgctc agtgacaact tgaccgcaga tatccaagga
     3181 gctgctcact cgacccgctt acgggtttgg acaactcgcc tcgacaagtg ggccgatcct
     3241 tctaagcaga tgtgcaatgg cgggcgcagg catggtcagc tcgaccacgc ggtcgcgtgc
     3301 tcctggacga actcggcgaa ggtgcggggc gggcggccgg tcaggtcgag gaccgcggtg
     3361 ctgatctggt cgtcctggcc cgctctgatg ccgtcttcca cggcggcgag cgcggccgcg
     3421 aagtcggcgg cgatacccgc cgcccggtag gcggccgctt ggtcgtcgac ctcggtgcgc
     3481 accacccgga cgggccgccg ggtgtgggcg gtgatgatcg ccgccgcgtc cgggtagctc
     3541 agtgccttcg ggccggtgag caggtagtcc cgctgctggt cgccgggccc ggtcagcagg
     3601 gcgaaggcgg cggcggcgat gtcgcgcgcg tcgatccagc ccagcctgcc gtcaccggcg
     3661 gcggtgcgga tctcgccgtg ccgccgaatc cgctcgccca gcgggtgcgg gctcaggaag
     3721 ttctgcatga accccgacgc gcgcagcacg acccaccccg gctgggcacg cacctgcgcg
     3781 gccagttcca gcgcgctggg cgcgttcggc agcacgatgg ccgaaccgag gagcaccacc
     3841 tggcgcacgc cgcggcgtcg ggcctcggcc aggaacggct cgacgagcgg catcgggtcg
     3901 gcgctttcca ccggcggcac gaggaagacc cggtccaccc cgtgcagcgc ggctgggtgg
     3961 gtggccgggt ccgcccagtc gaaccggatc gcggcggggt cgcggtccga cgggtggcgg
     4021 ctcgccaccc ggaccggaac accgttggcg cgcaacagtt ccaccaacgc gcttccggtc
     4081 ttcccggtgc cgccggtcac cagcacggcg ttcatcgggc gacctccgtg cccagcgcgt
     4141 cgagaagctc gggcagcgtc ccggtcgcgg aagcggtggc cagcgggttc cagtagtccc
     4201 ggtagcgggt gatcagaccg tcctggacgg tgatcaccgc gatgtagtcc agccggtagg
     4261 gctctccggt gcagagcgtg cgcccggtcg cgctgaactc cgcgacgacg gtgtcggggt
     4321 tttccatgtg gtgcacggtg atcgcgggca cctcccgcat gtccagcacc cccggcaacc
     4381 gtcccaagta gacacggatc gcgtcccgcc cggtcaccag gcgaggcgaa gtcccgacgg
     4441 cgaaaggaaa ctcggcgacg ccgtcttcgg cccacaggtc ggcggccgca tcggtgtcct
     4501 tgaccagcat cagatccaac atccggcgaa gcgtctcttc gggactgctc ggcacgatgt
     4561 cctccaggtg tttcgacgag gtgtgaccag tccagagtgg acagggggtg cgccgacgcg
     4621 gaacagcgag ccgagccccg gaccgccagt ccgtggctaa gccgggcggc cgatgccatc
     4681 atgggtggcg tgagcagagc cgaactggcc gatttcctcc gccgcaggcg ggaagcactg
     4741 cgcccggacc agcttcctgc cgccgccacc cagccgggcg gccgtgcccg ccgcaccccc
     4801 ggactgcgcc gcgaagaggt cgccgcgctg gccgggatgt cggtcagcta ctacgaacgg
     4861 ctggagcagg cccgcgcgcg gcgcccttcc ccggaagtgc tggcggtact gggaaccgcg
     4921 cttcagctca ccaacgccga acgcgagcac ctggcgcggc tggccgggca gatcccggcc
     4981 agcaccggcc gcaggcccgt gcccgccgaa gcccgcgggt tgctggaccg gctcgggtcg
     5041 atccccgcct acctgatcga cgagcggcag gacatcgtgg cctggaacag tgcggcggcc
     5101 gcgctgatcc cccgtttcga gctgctgccc gccgaggacc gcaacaccgt gcggctggcg
     5161 atccggctcg gtggcacctt ctgccgggct ccggcaggcg aggagcgcga gttcgcccgg
     5221 cagttcgcgg cccagctccg cgcggccagc gcccgctacc ccgccgaccg cgtcctcggc
     5281 gaactggtca acgaactcgc cgcgcacagc ccggagttcg cgatcggctg gcgcgatcac
     5341 gacgtgcgcc ccgtcgcggc gctgcgcaag tacctgcgcc accccgaact gggcgagctg
     5401 gacgtggtct gccagaccct gctggtcccc ggcaccgagc tgcagctggc gatgtacacc
     5461 gcggaaccgg gcagcccgag cgccgccgcg ctcgccaggc tggcgtgacc cggtaccgtc
     5521 cggcccgtgg cttccctgga caagatcgcc tggctccggc tggcggacga gcgcgtcctc
     5581 ggcgcgcgct cgcacggcaa ggacgcgttc tacctccccg gcggcaaacg cgaaccgggt
     5641 gagaccgacg tcgagacgct cgtgcgggag atcggcgaag agctggcggt cgcgatcgac
     5701 cccgcgagcg ccgtgcggtt cggagtgttc gaggcgcagg cccacggcaa ggcggcgggc
     5761 gtgctcgtcc ggatgacctg ctacaccgcc gagttctccg gctcgctcac cgcgagcggc
     5821 gagatcgcgg agctggcgtg gctcacctac gccgaccgcg accgcgtctc ccccatcacc
     5881 cgcctcgtct tcgagcacct gcgcgaacga ggcctgctgc gctgaccgcc acgacgcgtg
     5941 atggcagaaa aggtgggttc ttcgacgttg ccgccatcct gacgcccggc cagcatggga
     6001 ggcatgcgaa ccgcggcggt gctcttcctc ctcttcgacg gggtgcagag cttggacgtg
     6061 acgggcccgc tggaggtgtt caccagcgcc aacggctggc ttctcgcaca cgggggaaag
     6121 cccgcttacg cgatcaccac agcgagcgtc ggcggcgcgg ccgtccgcac gtcgagcggg
     6181 ttgcggatca cgccggacgc cgacctcgcc gaggtcgcgg tgcccgatct ggtggtggtg
     6241 ccgggtggtg aaggcacctg gtcccctccc ccggagctaa ccgcgtggct gcgcggcacc
     6301 ggacccggcg tgccgcgcct ggtttcggtg tgcacggggg ccttcctgct cgcggaagcg
     6361 ggcctgctcg acggccgccg cgccaccacg cactgggcct actgcgacgc gctggccgag
     6421 cggtacccgg acgtgctggt gtcggacgag ccgatctacg tcgaggacgg cccgctcgcg
     6481 acctcggccg gggtcaccgc gggcatcgac ctggcgctgg cgatcgtcga agccgatgtc
     6541 ggcagggagg tcgcgctgac gatcgcgcgc tacctcgtga tgttcctgcg ccgcccgggg
     6601 aaccaggcgc agttcagcac gcagctgtcc gcgcaggtgg ccgaacgcga accggtgcgg
     6661 gaggtccagc ggtggatcgc cgagcacccg gacgccgatc tttcggtgga ggcgctggcc
     6721 aggatggcga gcctgtcacc gcggcagttc gcgcgcgtgt tcgccgccga agtcggcgtg
     6781 aaccccggcc ggtacgtcga ccgggtccgc gtcgaggcgg cgcggcggct gctcgaagac
     6841 accggccgcg gcgtcgaaga agtggcccgc gactgcgggt acggcacccc cgaagcgatg
     6901 cggcgagcct tcctgcgggt gctcgacgtg agccccgccg aataccggcg ccggttccgg
     6961 ccggcccatt cccgaggaga atcctgatgc gcgttgccat cctgctctac gaccggttca
     7021 ccacgctgga cgcgacgggc ccgtacgagg tgctcggccg cgtccccggc gcggaagtgg
     7081 tcttcaccgc cgagcgcacc ggccccgttc gcaacgacct cggcagcctc gccatcgtcg
     7141 ccgacgcggc actcggcgag gtcgagtcgc ccgacatcgt gctggtaccc ggcgggccgg
     7201 ggcagcgcga gctcatgacc gacgggccgg tgcacgactg gctgcgggcc gtggacgcga
     7261 cgagcacgtg gacgacctcg gtctgcaccg gctcgctcat cctcggcgcc gccggtctgc
     7321 tcaccggaag gaaggccacc tcgcactggc tcgcactgga ccagctcccc tcgttcggcg
     7381 cggaaccggt gagcgaacgc gtggtcgtcg acggcaagta cgtgaccgcc gcgggcgtgt
     7441 ccgccgggat cgacatggcg ctgacgctcg ccggccggat cgcgggcgac gaggcggcgc
     7501 aacggatcca gcttctcacc gagtacgcgc ccgccccgcc gtacgacgcg ggcaggccgg
     7561 acaccgcgcc cgcggagatc gtcgccggga tgcgcgcgca ggcttcccga agctgattcc
     7621 gggcacatct gtccacaagc gacattcaag gagaacccct gatgcgcgtt gccatcctgc
     7681 tctacgaccg gttcaccgcg ctggacgtgg tcggccccta cgagatgctg tgccgccttc
     7741 ccggcgccga agtggtgttc accgcggagc gaaccggccc ggtccgcaac gacgcggaca
     7801 gcctcaccct cgtcgcggag gcgtcgctcg gcgaggtcga agcaccggac atcgtgctgg
     7861 taccgggcgg ccccgacacc cgcggccccg ccggcgacgg cccggtgcgc gactggctgc
     7921 gcgcggtcga cgcgacgacc acgtggacga cctcggtctg caccggctcg ctcatcctcg
     7981 gcgccgccgg tctgctccgc ggacggcgcg cgacctcgca ctggatcgcg ctggaccggc
     8041 tcccctcgtt cggcgccgtc ccggtgagcg agcgcgtcgt caccgacggc aagtacgtca
     8101 ccgcggcggg ggtttccgcc gggatcgaca tggcgctgac gctcgcggga gagatcgccg
     8161 gagccgaagt ggcgcaacgg atccagctcg gcgcggagta cgcgccggag ccgccgtacg
     8221 acgcgggcag gccagacacc gcgcccgcgg agatcgtcgc cgggttgcgc gcgatgagcg
     8281 cgcagatcct tcagggctga ggcgataccg cgcggcgggc cagcgccaac acgcccacgg
     8341 tgccgagcac gcccgccgtg ccgatcacag tcgccggcgc gaccagcgcc gccaccgcgc
     8401 cggcgaccgc gatcccggcc ccctggaccg ccatcaaccc tccactttgg accgtgaaga
     8461 gcctgccgcg ggccgcggga tcggccgcgg cgaggacgac cgggtcgacg cactggttga
     8521 acgcggaccc ggtgccggag aggacgagca gcgcggtggc gcaccagacc ggtggcacga
     8581 aggcgaaggc ggccagggga agctggttca gcagcagaag cgggaacagc agccgccgcc
     8641 ggacgtgcgg ccgcagggtg gccacgacga tctccccggc gacggtcccg gtggcatacc
     8701 ccgcgagcaa cgcacccgaa ccggccacgg gtgcgcccgc ctgcgcggtg taggccaccg
     8761 cgagcccgct cgctacggag ctgaacgcgg gcgccgccca cgacagcagc aggaggcggc
     8821 ggacggggac ccgcgcgaac accgcgcgga aacccgatcc cccggatccg ccgtcccggc
     8881 gcggcaccgg ggtcgagggg gtgcacagtc cgatgaggac ggccgagacg aggaagctgg
     8941 ccacgtcggc cgcgagcagg cacgcggtgc cgatcgtggc gacgagcgcg ctgcccacgc
     9001 cgaacccggc gagcacggtc gactggctga cggcccgcag cagggaccgg cccaccggga
     9061 agaggtccgc gtcgagcagg tgcgcgaggc tgccggcgcg ggcgccctgg aagaccgggg
     9121 cgaggacgct ggtgaccacg aggagcgcga gcagtgccac gaccggcagc cccggcacga
     9181 gcatcgcggc gacgcaggcg gcgctgagca gatcgcagca cacgagcagg ccccgtgcgg
     9241 ggaaccggtc ggcgatcggg gacagcgcgg tgccgccgaa cgcgtggggc aggaacgagc
     9301 aggccagcac cagcgcggac agcagcggcg agcgggtgcg ctcgaagacc aggatggaca
     9361 gcgcgacctc ggccgcgatg gtgcccgcca tggacaccgc gtgcgcggcg aacacggcgc
     9421 gcatccccgg cgcgcgcagc accgcgcgat acccgtgaga ggccctggag acgggaacag
     9481 tgctcatgca cttcagcctc gtggcaaggt cgatgcaccg ataagctttc ggctgtgacc
     9541 gaaagaccct gctcatgacc gtgatccggt tcggcgagtc cgacgcggcg cggtgccggt
     9601 tcggcatttc accgctctgg gaaacgctct ccgcggtccg cgtgctgcac aaccaccggc
     9661 accgcccgct gtattcgccg tgggtgtccg ccaaggcggg cctggcgaag ggcctcgatc
     9721 tcgatccggt gcgggcggtg cagccgcggg tcggtcacac cccggacttc ctgaccccgc
     9781 caccgcgcac accgcggacc gagttcgccg gtgagctggc gcgggtgcgc gccaccccgc
     9841 cgggccgggt cgcggccgag ctggccagga cgcgggacca gccggcgaat ccgcgcgccg
     9901 cggaggtcga ccggatgctg gccgaccccg ccgcggcgcg ggaccggctc gccgacgcgg
     9961 tggaggccgc gtgggaggcg ctgctcgagc cggactggcc gaagatcagg cgggtgctcg
    10021 aagacgacat cgcccaccgc ggccagcggc tcaccgaggg cgggttcggc gcgttgttcg
    10081 acgatctgca cccgacgctg cgctgggaag gaacccagct ggtcgcgagc aagtaccgcg
    10141 accacgaccg cgacctcggc ggcgccgggc tgctgctggt gcccggcgtg ttcgcgtggc
    10201 cgtacctggt cgcggtggtg gcgcccgcct accagcccgc ggtgctgtac ccggcccgcg
    10261 gcgcggcgcg gttgtggacc accgcgccgc ccccaccgga ccggctggcg cgcctgctcg
    10321 gccgcagcag ggccgccgtg ctggcggcgc tggacccgcc gtcgagcacc accgagctgg
    10381 cgggccggta cggtctcgcg cccgcgaccg tggccgagca cctcggcgcg ctgcgcgacg
    10441 ccgggctggc cgacaagcgg cgccacgggc acgaggtccg gtaccggcga acggaactgg
    10501 gccaggcact ggtcgacgcg gccgtcggct gaacgggaac aggcagtcca caagagacag
    10561 tcgcgatcag gcagcactcg gcctgtgccg cgagggccgg gaaagtggct ccagcgtccg
    10621 cgaaggtggc gctcgcgttc atccctttcg gaacgctcac gtccggcccg aagtgccctc
    10681 agccgccgag gacgaccagg tgcagtgtgg ccgagccgaa gaacgggcgg ttcgcgaggt
    10741 gggcgagcca gtcgcgtgcc gcctcctcgg tgaggtaccc gtcggcgacc gcgcgcccgg
    10801 tgacgcggtg cagcccgagc acctggtccg cggccgtcac gtcgcggaag accgtggtca
    10861 ccgggacgac gtcgcggacc tcgaaccccg cgtcggcgcc gtaacgcgcg agcgaccgcc
    10921 ccacggtggc gttgcggacg gcgcgctcgg tcacgtagcg ggtgtaggcg cgggcggtgg
    10981 cgaggtcggg gtggtcgatg gcgagggtgt cccagtccgg ctccgcgagc acggcgacgc
    11041 cgccggggcg cagcacccgc cgcagctccg caacgaccgc gaccgggtcg gcgacgtgct
    11101 gcaggacccg gtcggtgtgc gcccggtcgg cggaggcgtc cgggaggtcg agcgcgtgga
    11161 tgtcgccttc ccgcacatcg gcccgcggcg gcgcggtcgc acgggccttc tccagctgca
    11221 cccggtcgtg gtcgatcccg atcacccggc cgccttcgcc cgcggcctcg gcgaaggcgg
    11281 ccaggtccgc gccggggccg cagccgaggt ccagcaccac gtcaccgggg cggatgtcga
    11341 gcaggctggc cgcgagccgc ttgtacgcgc tgcccgcacc cgaccgggcg agccgcagca
    11401 ggtagtcgcc gggccgggtc gtctcgaaca cgtccatgtc acccgagtga accagaccac
    11461 cgcaatcccc aggtcaactg cgggcacgtt ccgcacacgt tctattctcg accccgatgc
    11521 gaaaatactt ctggggcgtg ctcgcgctgg cggcggtcgg tctgtacttc tccgtccggt
    11581 tgctcctcga cgacctcccc aacgcgcatc tcgacctcga ggtgtaccgc tacggcgtcc
    11641 aggcgtggtg gcacgaccag gacatgtacg gccagctgcc cccggtcgcc aacggcgcgc
    11701 acctgccctt cgtgtacccg ccgttctcga tcctgatcct cggcccgctc gcgatcctgc
    11761 cgtggacggg tgcgatcgcg gcgctctaca cgatcaacat catctgcctc gccatcacgc
    11821 tgtacctggt ctccaggcgg gtgtgggcca agctcgaccg gcgcggcggg atcatggtcg
    11881 ccgcggtcgc gacgccgatc gcgctgttct tcgaaccggt caacgacacc ttcgagttcg
    11941 gccaggtcag catcatcatg atggccgtga tcgcgatcga ctgcctcgcc gggcgcacgg
    12001 tgtggccgcg cggtttcggc atcggcctgt gcgccgcgat caagctgacc cccgccgcgt
    12061 tcctgctcta cttcctcgtc cgcaaggact acaaggccgc gatcaccgcg gggatcacct
    12121 ggctggcggc cagcgcggtc gggttcggcg tggactggac ggcgtcgatc cggtactggt
    12181 tccagggcgg ctcggccgcg gccggggtca gcggcaccgc gttcaagacc aaccagacga
    12241 tcaacgcggt gctcgcccgc acggggatgc ccgagggcgc ggtgaagatc ctgtggctgt
    12301 tcctcgcggc agcgctgctt gtgctggtgg cgctggcgat gcggaactcg gagccggtgc
    12361 tggcgctgat ggcgaacgcg ggcctcggcc tgctggtgtc gccgacttcg tggtcgcact
    12421 acttcgtctg ggtggtgccg accgtgctgg tgatgatcgg ctacctcggc aagcggtggt
    12481 cggcgaaatc gcccgccttc gcgggctggc tcgtcgcggg gctcgccacc gcggcggtgt
    12541 tctacctcgc cccgttccat tcgctgccgg acaccgaatt cccggtggtg acgcaggact
    12601 ggacgcccaa ggaccaggtg ctcaccgcgt cgtacgtgct cgtcggcgtc ccgctgctga
    12661 tcgcctacgc gatcccgcgc ctgcgggcca agcgcgccgc gcggcccgcg ccggtcaagc
    12721 ccgaagccga gcccgtcgac gctgccagtc cgtgacggcg ccgaggccgg agtccagttc
    12781 ctcggacaac agcgccgcct gctgagaagc cagctcggta cccagtagct cggcgggccg
    12841 cgtgctttcg gtgaacgcgc gcaacgcctc ccacggcgtg ctcgccaacg caccggccgg
    12901 ggttccttcg ccgggcaccg cgaggccgtc ttcgatcccg gcgcggcccg acgcgagcag
    12961 cgccgccacg acgaggtgcg gctgcgcgtc ggcaccggcg aaccggaact ccagccgcgc
    13021 cgagtcgccg cgaccggcca gccgaacggc ggcggtccgg tcgtcggtgc cccagcgcag
    13081 ctcgatcggc gagaacggcg cggtccgcag ccgcacgtag gagttccagg tcggtgccca
    13141 gatcggtgtc agcacggccg cgtcgcgcag cacgccgccg aggaagtgcc ccagcgcccc
    13201 ggtcatcccg gcctgaccgt ccgctgtgga cagtgacagg tgcacgtggc acgagctgcc
    13261 ctgccccggt tcgggcgcgg cgaggtaccg cgcttcgacg ccgtggcgag cggcggccgt
    13321 gcgcacgagg tgctgaagca gcatcgcgtc gtcgcacgcc gcgagcgcgt cgcggtgccg
    13381 cagcaccagc tcgtactggc cgggatggca ttcggcccgc gcggattcca gtccgagccc
    13441 cgcaccgtcc acatcggacc gcagttcgcg caggagcggc gcgagctttt cggtgccgcc
    13501 gagcgcgtag tcgacgccgt ggccggtcat cggcgcgccg tcggcaccgg tgaacacgac
    13561 ctcgtgctcg atgccgaccg acggcacgaa accgagttct tcgagcgtcc gcagctgcgc
    13621 ggccagggcc tgcctcggcg cggcggcgac cggctccccg ctcggccatt cggcgtcgca
    13681 caccaccgcg gacgtcccgt ccggcagcgc ggtcagcgac gcgaagtccg gccgcagccg
    13741 cagatcgccg tagcggtcgg cataacgccg cagcgattcg tccacttcgg acagcgcggt
    13801 gcgttctggg ctccagcaga agacataggt gcagagcccg taaccgtgct cgcgcacctc
    13861 gtcggcgacg aaccccgcgt ccagctcgac ggccgcgaaa cgcgcgtgcg gatccggcac
    13921 caacagcagc aggcggccgt ccggcgggct ggacgggcgg cgttcggcga gcgcgcgcgg
    13981 ccccagcggg cgcggcgaag tcaccacgcg ccgccagggt ccggcgcgtg cagcgggttc
    14041 ggcacggtgc cccagcggac gtcgaactcg tcgtcccgct ccaccttgtc gaaccccttg
    14101 cccgccaggt gttcgcggtt cagggtcacc cgctcgacct cgggcgcgaa caggcggcac
    14161 gcgtcgaacc gcgcggcctc ctccgggttc tcgtcgcgga accgcgtcac cacctcgcgc
    14221 acgagcgccc agaaccgggc gcgcggcagg ccgagctcgt cgagcaggat ctccgcccag
    14281 aaccgcagct gaccggagaa caccgagctg aacagcgact gcgccagcag gtgcgccggc
    14341 cagcgcagca tctcggcgga ggcctccggc gccatcgacc agtagcagtc gaggtcctcg
    14401 tcgaggaggt cgacgccctg cgcgaagtcc ttgatcgcca cccgcaacgg gaccccggcg
    14461 gagtcgacga ccagcacgag gttctggccg tgcgggcaga atcccacgcc gtagcgcagc
    14521 agccagcgca gcaacggcgt gagcagcagg tcgaacacgc gcccgcacca gtcctccgcg
    14581 ccgagccccg atcggccgat cacctcggcc agcaccgact cgccgtcggg accgcggtag
    14641 ggcagcgcgg cgaaggacag cgcctgctcc ccgtcggcga ccctggccag caacggctcg
    14701 cgccacaggg ctcccagcgt ttcgtggaac cggtagggca gctcttcgag cgcgccgaac
    14761 accgggtgcc ggaccgacac gctcgccacc tcgccgagca gttcgaagcg gtattccctg
    14821 gacagcacgg gatcggccgc gtcgatcgcc ttgagccacg cggtgatcgc gggcccggcc
    14881 agtgtcgccg ccgagttgag gccgcggtag acgagcgtgt tgcgcaccga cacggccgtc
    14941 ttgacgtcgc ggcgctgtgg cctgcccacg ttcgccagcg tccggaccgt ctgatgtgga
    15001 cggtagtggt cccagcccgg cccgaggtcg atcagcgcgc cggtggcgag ctcccccgcg
    15061 tacaaggtgc ccacgatctc gtcggcctgc cacgggtgcg ctgggaccca caggtagtcg
    15121 gcgggatcgg cgcccgcgtc ggagatcacc gcggtgaact cggcgcgctg ctcgtcgtcg
    15181 agttcctcgg cgagcagttc ctccgcgctg aggccgtcga cgcagcggaa ccgggcgtgg
    15241 tcgcggtgca ccgcgaacca ccggagcacc acgtcggcgc ccgcctccgg cgagtaccgc
    15301 tcgcggtcgg ctgcggagaa cccgaccctg cccttgttca gcaccagcct cggatgcccg
    15361 gtgaggtacc cttcggccag attgtagtcc atagtggaca gacgggccgc ggtcggcgcg
    15421 gcggcgatcc tggtggcctc gttggtcacg gtggcggtca gctccgccag cacgtcggcg
    15481 agccgcagcc cgccgagccc gagcacggca cgcgcgtcca cgagcagcgc gcgtgggtca
    15541 tcggcgggtt cgggagcgtc gtcaccggcg gctctggtcg cgctgcccgc cgcgacgcac
    15601 cacgaatcga acgcgccgcg gcgggcgcgg aactcgtacc gcacgtcgcc cggcagcacc
    15661 agccgccacg gccggtgccc gtcttcgccg ggttcaccgg cggcttcggg gtcgaggagg
    15721 cgttcgtagg acaactcccc cagcatcttg tgcaggacga gcgatcccgc cgcgcgccag
    15781 gcttcggcct gcccgatcgc gtcgtcgccg gtgccggtca gggtgctggt cactgctcct
    15841 ccaggggtag gccgaacgtg gtgaacgcgg tccggtcggg cagggggtag acggtgcggc
    15901 cggtgaccgc gttgacgatc gacgccgcgc gccacgcgcc gagtccgaga tccggggtcc
    15961 cgaccccgtg cgtgtgccgc tcggcgttct gcacgtagac cgtgccgggg atcttctccg
    16021 gcaggcgcag gcgataaccg cgatcgactt ccagcggcac ggtgaaatcg acgccgagcg
    16081 gggcgagcag ctcgtcgagc ggcgtgtcgc ggtatccggt cgcggcgacg accgcgtccg
    16141 cttcgagcac ggtttcggtg ccctgctgga cgtgccgcac gccgagttcg acaccgtccg
    16201 ccgtccggcg cgccgagaag acctcgacgc cgggcatgag cgtcaccttc ggccacgtgc
    16261 cgccgatccc ccgctcgtac agcgcgccgt ggatccgcga aagggtttcg gcgtcgacgc
    16321 ccttgtacag ctgccattgc gcgggcagga gccgctcgcg ggttcgttgg ccgagaccgt
    16381 ggaagtaggt cgtgtagtcc ggggtgaact gttcgaggcc gagcttcgaa tactccatcg
    16441 gcgcgaacgc ccgcgtcctc gccagccagc ccagtccgtc cactgtggac cggtgctgga
    16501 gctggtcgag gaacacctcg gcaccggact gcccggaccc gaccacgagc acgcggcgcg
    16561 aggccagcag ccgggcgcgc gcgccgaggt agcccgccga gtgcacgacg ggcgcgtccc
    16621 ggccggacgc gagctcccgc agcggttccg gcaggtgcgg caccgtgccg acgccgagca
    16681 ccaccgaacg ggcgagcacc gggtcgcgat cggcgaaccg cagttcgaac gcgtcgccgg
    16741 accagccgac cgaacggacc tcggcgccga actcgcaggc gggcagccgc tcactggccc
    16801 agcgcgcgta gtggtcgtac tcggcgcgcg ggatatggaa ccgttcggcg aagtagaacg
    16861 ggaagagccg ccggtgctcg cgcaggtagt tgaggaacga caacgggttc gtcggatcgg
    16921 cgagcgagac gagatcggcc aggaacggca cctgcagcgt ggtgccgggc agcagcaggc
    16981 cgggatgcca gcggaactcg gggcgccggt cgaagaacgc cgcccgcagc cccgtgaccg
    17041 ggtgcgcgag tgcggcgagc gacaggttga acgggccgat cccgataccg gcgaggtcca
    17101 acggcgtcac gaaccgaccg tactctgtcc ggcgcggatc ccggtctcct gactcgcggc
    17161 cgcggccgcg atcaggtcga gcagcggcgc gtagtccacc ggcgtcacgc cggggtgcag
    17221 cagggtcagc ttgagccaca accgttccgg cccgccctcc ttcggcggca gcgccgccct
    17281 gccgacgacc gcggtacccg cttcgagcag cgccctgcgg acaccggcga ccagttcgtc
    17341 gcccagttcg tcggcggcga ccgggcggaa gagcacggtg gacaacgtcg gcgcgcccca
    17401 cagccgcagc gcggggtgct cgccgatcgc gtccgcgacg gccgccgcgg tgtccacgca
    17461 gtgcgcgacc agcgcgccca tcccgtcggt gccgagcgcc cgcagggtca ccgccatccg
    17521 gaacgcgtcg gggcgccgcg aggtgcggat cgaccgcccg agcagatccg gcaacccggc
    17581 ctcggtgtcg tcggcggggt tgaggtactc ggcgcggacg gtcagcgcgc cgagatcggc
    17641 cccttcgcgc gccgcgaaca gaccggcgga aatcggctgc cagccgaact tgtgcaggtc
    17701 gagcgcgacc gaatccgcgc ggtcgagccc gtcgacgagg tgccggaaac ggggcgagca
    17761 cagcgccatt ccaccgtagg cggcgtcgat gtgcagccgc gcgccacggg caccgcacac
    17821 ctcggcgatc gcgggcagcg ggtcgatctc gccggtgttc gtggtgcccg cggtggccac
    17881 caccacggcc ggacccggca ggccggacag cgcggtgtcc agcgcgccgg gcggcagccg
    17941 atcgcccgcg cagtccacca cgagcggcgc gggcagcccg agcagccacg ccgcccgcgc
    18001 gacgctgtgg tgcgcgtttc tgccacaaac cggcaccacg cccggctccc gttcgcgcgc
    18061 cagcaacagc cccagcaggt tcgattcggt gccgccggtg gtcaccacgg cgtccgggct
    18121 cgcggcgtcc gggtagcaca gtgcggcgac gcccgcggtg aactcgcgct cgatctcgct
    18181 ggccaccggg gcctggtccc aggaatccat cgacgggttg accgcgctcg ccacgacgtc
    18241 cgcggcgacc gcgaccgcga gcggcgggca gtgcaggtgc gccgcgcacc acggctcggc
    18301 cggatcgacc gagcccgcgg cgagcagcct gccgagcccg tcgagcgcac gcacggctcc
    18361 gacgccttcc ctcggcagca tcggcgcgtc cgcggccaga ctcgccgcga ccgcggcagg
    18421 gccgcccgcg ggggcgggcc ctcctcgctc cgccgttcct tcggcgaaag cgcgcaatgc
    18481 caccggaatc agctcggcga gccgccggtg tcccgccgcc ccaccggcga gcgacccggc
    18541 atcgggcgtc gagtcagcca catagtctcc ttaggtttgc ctaccctcag caacaatacg
    18601 gacaccggtg gcgccgatgt cgacgggcca cccgctcgag ttgctcgctt ttgacttata
    18661 taagtggcgg ctttagcatc ggccctgtcc gacgacgacg aaagagattt tccatgatcg
    18721 atttgctcgg ccagctctcc gaggcccacc gcgagctcgg cacccggggg aaagcccgca
    18781 cggtcctgct ccgccgcacc tacgccgcca cccccgaaga cgtgtgggac gcctgcacga
    18841 agcccgatcg gatcgcccgg tggctcgggc cggtcgaggg cgatctccgg ctcggcggcc
    18901 gctaccagat cgaaggcaac gcgggcggcg agatcctccg ctgcgacgcg ccgaaactgc
    18961 tcgcggtgtc gtgggtgttc ggcgagaacc cggccaccaa cacctccgag gtcgcggtga
    19021 ccctgtcccc cgcgccgggc gggcacacgg agttccagct cgaacacacc ggtgtcgatg
    19081 tcgatcccga acactggggg aagtacggtc ccggcgccgt cgggatcggc tgggacctca
    19141 gcctgctcgg gctcgccgcg cacctgggcg gcgaggaaag cgcgcaggat ccggaagaac
    19201 tgctgcagac cccgggagcg ctcgaattca tgaagcgcag cgggcaggcg tggggcgccg
    19261 cgcacgaggc cgcgggcgtg agccacgacg aggcgaaggg cgcgatggaa cgcaccatcg
    19321 ccgcctacac cgaggcccca cctgcggaat aactcccttg cttaccctga tggccaccat
    19381 cacggcgctc agtgcccgga actcggcctt cacgacggca ctttccgggg cgggacgggg
    19441 tcgcaacgcc gtgatggcca ccatcacggc attcagtgcc gtcatggtgg ccatcaggga
    19501 cttcaagggg cggccccgag gaggctagcg gcgcggggcc aggccccgta cgtggtcgaa
    19561 cgggtcgccg ccggtgggca gcacgctgat caccggcgtg tccagcccgt tgtccacata
    19621 ggactggaca cgctcgcggc actcgtcggg cgagccgtgc accacgagat cgtccaccac
    19681 ctcgtccggg atgacggtgt tcgcgcgctg ccggtcgccg gcggcccacg cctcgtgcat
    19741 cggggcgagc gcgtcaccgc ggccgagcca gtcgtgaaac ttcgcgtaca ccggcacggt
    19801 caggtagctg ctgatcagca tgcggccgag cccgcgcgcg gcatcggcgt cttcggtggg
    19861 gcacacgaag atcctggcga ccagttcgac gtcctcgccg atcacctcgc ggatcttcgg
    19921 cacgtcggtg ggggcgagcc agttcgtgat cgcgccgtcc gcctccttcg cggcgaggcg
    19981 cagcatgccg gggcgcagcg ccgccagcat gatcgacggc ggcgggtccg gcggccgctc
    20041 cagccggaac ttactgaccg agaacgtctt gtactcctcg ctcaccttct cccccgccag
    20101 cgccgcgcgc aggaagcgca gcgtgtcacg ggagcggccg aacggatcgg cgaactcggc
    20161 cgcgttccag ttccgcacga tcaccggtga cgacgcgccg atgccgagca cgaaccggcc
    20221 cggcgccgct tcggcgagcg tcgccgcgct catcgcgagc aggccgggcc cccgcgtgta
    20281 gacgggcgcg atcgcggtgc cgagccgcag cgacggagcc cactgcgacg ccagcagcag
    20341 cggcgaaaac gcgtccgtgc ccgcggtttc cgccgaccac gcgtcggtgt agccgagatc
    20401 gggaagctgt tcgatgagct cgcggtgcgc cgcgagcggc accccggtga gcgggatggt
    20461 caaaccccac cgtgccacgt gttcctcctg cctcgtaaag cttcgtaacg gaaacctcag
    20521 cccagttccc ggtggagcca gccgatctgc acccgcatca ggttctccgc gacctcttcc
    20581 gcctgcgggg tcatatgggt cgcgcccgcc agcgggagga acgtgtgcgg ccgtcccgcg
    20641 gcgagcagcg cgccggaaag ccggagggaa tgcgcgacga acacgttgtc gtcggcgagc
    20701 ccgtgcacga tcagcagcgc gcgctcgagc cccggcgcgt cggcgatcag cgagttgcgg
    20761 cggtagtcct cgggattgtt cgccggcgtg cccaggtacc gctcggtgta gtgggtgtcg
    20821 tagagggacc agtcggtcac cggcgcgccc gcgacggccg cgtggaagac gtccggccgc
    20881 cgcagcacgg cgagcgcgga caggtacccg ccgtaggacc agccccggat cgccaccctg
    20941 ccgaggtcga gatcgggata ctgctccgcc gccgcgtgca gcgcgtccac ctggtcggcg
    21001 agcgtgaccg acgcgagttc cccgctgatt tcccgttccc acgccgcccc gcgccccggc
    21061 gtgcccctgc cgtccgcgac gagcaccgcg aatccctggt cggcgagcca ctgcggggtg
    21121 aggaacgcgt tcctgctccg cagcacgcgt tgcgcgtgcg ggccgccgta cgggtcgagc
    21181 agcaccggca gcttcgtgcc ccgccggtgg ccgcagggga acagcagcgc ggcccgcaac
    21241 ccgcgttcgc cgagggtgag cagcaccgga tcgggttcga gcccgggatc gacggtgtgc
    21301 gaagcgatcc cggcgatcgg ctcgccgtcg cggagcacgg ccacttcggg gccgctgtgc
    21361 gcgaggctcc acgacgaaag caccgtcacc gcggcggatc cggagccgac gtgcacaccg
    21421 tccgttgtgg acagacgacg gacgccgccg cccggttcgg tgcggtagac gtggatctgc
    21481 gtagggtccg cttcggatcc gctgaacagg atctgcgcgc cggtgttgag caccgaccgc
    21541 acctgcaggc ccggcgggct gaccggctcg ccgtcgagca ccagccggta gtcgccgtcg
    21601 gccgagctga cgcggaccag cctgccgtcc ggcgtccacg cgggcacccc ggtgacgatt
    21661 tcgatccact gtggatcggt ctcggtgtgc aggaccctgg tgctgccgtc ggcgggatcg
    21721 acctcgacga cgtccatccg gcgctggtcg cgggactgca ccgcgagcag cgggttcccg
    21781 cccgcggacc agtgcaccgc ggcgacgtac tcccagtcgc ccgcgcgcac gtcggtccgc
    21841 ttcccgtcga gcccgacgaa agccagtgac accttgacgt tcgcctcgcc cgcggccggg
    21901 taggcgacga cgttcgcctc cttcgccggg tccgcgggat cggcgatcgt ccacttcgga
    21961 acgccggcgc gatcgctgcg ttcgacgagc aggctccgcc cgtccggcgc ccaccagtag
    22021 ccccgcgccc tgctcatctc ctccgcggcg atgaactccg cgagccccca cgcgacgtct
    22081 tcgccgtcct cggtgaccag ctcgcggtct tcaccggtgg ccagctcgac gacgcgcagc
    22141 ctgcggtccc gcacgtaggc cacgtgggtg ccggtcgggt tcggccgggg gtcgaccgcg
    22201 cccgtcgccc cgtcgagcag caccgcggtc tccccggtca ccaggtcgac ggtgtgcagc
    22261 ctgccggaca acgagaacgc ggcgatccgg gaggcgtcgt ccaccgcgta cccgacgacc
    22321 ccgcccgagg tctccctcgc ccgctcccgc cgggcgcgtt cctccgcggg cagctcttcc
    22381 tcgcccggca gcagttcggc ggcgtccacc agcttctttt ccacgcccgt cgcgagatcg
    22441 agcgcccaca ggctgttgcg cgggtcggtg ccggattccg cgcgctggaa cagcacgcgc
    22501 gaaccgtctc cggcgacctg gaagttcttg ggcgcgccga gtgtgaaccg ctgggtgcgg
    22561 gcctggcgtc ggaggaagga gtcgcggtcg atcacacccg gcactctttc agacgatcat
    22621 gtgccgacgc caacgtcacc cgagtttcgc cagctcggcg tccacgtcga agtccggctg
    22681 cgggaaccgg ggagccatct ccgcgagcgt ctcggtgagc agcctggcga ccgcccagtt
    22741 gcggtaccac ttgcggtccg ccggcaccac gtaccacggg gcgtgcctgg tcgaggtccg
    22801 gcgcagcacg tcgcggtagg cccgctggta atcgtcccat ttggaccgcg cttcgagatc
    22861 ggccgagctg tacttccagc gcttcgacgg cgtggtcagc ctcgcccgca ggcggcggag
    22921 ctgctcctcc ggcgagatgt gcaggaacac cttgacgatc gtggtgccgg actcggcgac
    22981 ctcgcgttcg aaggcgttga tctccgcgta ccggcggcgc cattcgccgg cgggcaccag
    23041 cttctcgacc ctcggcacca ggatgtcctc gtagtgcgag cggtcgaaca cgccgatctg
    23101 gccgggatcc ggcagccgct tgcgcacgcg ccacaggtag tggtggcgcc gctcggcctg
    23161 cgtcggcgct ttgaagcccg cgtaccgcac gcccatcggg ttcaccagcc ccagcacgtg
    23221 gccgaccgtg ccgcccttgc ccgaggtgtc catgccctgc agcaccagca gcacgctccg
    23281 tccgccaccg tcggcgccct ccgcgtagag cgcttcctgc agttcgtcga gccgctcgcc
    23341 ggtggtcgtc agcttcttct gcgccttcgt cttcttctcc ggcccgatcg gcgacgagcc
    23401 cggatcgggc caggtctccc ccgccttcag cgcgtcgcgc accgcacgct tgcccatggg
    23461 tgtcctccct gtcgtcaccg ttcgtggccg acgataaccg cagcggcggc gcggggccgg
    23521 actcgcgaac gggccgcgtc gttccggcac aacgaaacgt cgcccgaatg cgtgaaaccc
    23581 gcaacgaaca acggcaccaa gcaacgttca ccggatgaaa tccactcctg cctggcctta
    23641 gcctgaacgt atgactgtgt acgccgagaa ggtcgccgag atgcccgcca ccagcactga
    23701 cgagttcatc gcgctcgacg agcaatgggg cgcgcacaac taccacccgc tgccggtcgt
    23761 gatcgccgag gcggacggcg cgtgggtgac cgacgtcgac gggaaccgct acctcgactt
    23821 cctttccggc tactcggcgc tcaacttcgg gcaccgccac cccgagctga tcgccgccgc
    23881 gcaggagcag ctcggccggg tgacgctgac ctcgcgcgcg ttccaccacg accagatggg
    23941 cctgttctgc cgcgagctgg cggagctgac cggcaccgag atggtgctgc cgatgaactc
    24001 cggcgccgag gccgtcgagt ccgcggtgaa gctcgcgcgg aaatgggcct accaggtcaa
    24061 gggcgtgccc gacggcaccg ccgagatcgt ggtcgccggg tcgaacttcc acggccgcac
    24121 caccacgatc gtgtccttct ccaccgacga aaccgcgcgc gccgacttcg gcccgttcac
    24181 cccggggttc gtcacggtgc cctacggcga ctccgccgcg ctcgccgccg ccatcaccga
    24241 ccggaccgcc gccgtgctgc tcgaaccgat ccaaggcgag gcgggcgtga tcgtgccgcc
    24301 gccgggttac ctcgccgaag cgcggcgcct gtgcgacgac gcgggcgcgc tgctgatcgc
    24361 cgacgaaatc cagtccgggc tggcgcgcac cggaaagctg ctggcgctcg accacgaaaa
    24421 cgtgcgggcg gacctgtaca ccctcggcaa ggcgctcggc ggcggcatca tgccggtgtc
    24481 cgcggtcgtc ggcagccgcg acgtgctggg cgtgctgcgt cccggcgagc acggctccac
    24541 cttcggcggc aacccgctcg cctgcgcggt cggccgcgcc gtcatcggcc tgctgaagac
    24601 gggcgagttc cagcagcgct ccgcggaact cggcgagcgc ctgcacaccc ggctcggcgg
    24661 cctgatcgga aacggcctgt ccgcggtgcg cgggcgcggg ctgtgggccg ggatcgacat
    24721 cgcccccggc ggccccaccg gccgcgaagc ctcgcgggcg ctggccgcgc gcggcgtgct
    24781 gtgcaaggaa acccacgaca acaccctgcg catcgccccg ccgctggtga tcagcgccga
    24841 agacctcgac cgcggcatcg acgccgtcac cgaggtcgtc acccgctgag ccgcgccgcg
    24901 cgaagcccac gccctgaagg tggctttcgg ggcatccagg tccccgaaag ccaccttcgg
    24961 ggcacgcgaa aacgggtcgg tcagcccgcg agtgccgcta cttcgtcggc gcagccccag
    25021 gaaagggtga ccccggcgcc gccgtggccg tagcagtgga tgacgtcgcc ttcgcggtcg
    25081 aggcgtactt cggggcgcca cggccgcagg ccgacccggg tgccgagcac ctccgcgccc
    25141 gccagttccg gtacgagcgc gcggcttcgg cgcacgatgt cttcggcgac ttcgggatcc
    25201 ggctcggtcc ctgcccgccc ccgttcctcg gtaccgccgc acaccacgtg cccgccgtgc
    25261 gggatcacgt aggtcaccac gtccgcgtct tcgtccacga cccattcggt gagaccgggg
    25321 tccgccaggt gcaccacctg cccgccgacc ggctccacgg tgctgtcacc ggcgagcgcg
    25381 ccaccgccga ggcccgccgc gttgacgacg agatccgcgc ccgccacctc ggcgaggctc
    25441 gcgagccgcc ggtgctcgac cgccaccccg gcttcggcta ccgcgccgga aagccagtcg
    25501 aggtaccgcg ccaggtgcac caccggtgtg ctgaaccgca ccgcgttcgt ccacggctcc
    25561 ggcacgtcgt cctcgcggac gagatcgggc atggccccgg cccagtacgg ccacggcgcg
    25621 ggtgcgcggt gcagcaggcg gccgggaaga acacggatgc ctatgtcctt ttcggacagt
    25681 cgggtgaact ccccgacccc ggccgcggtc cagcccgcgc accggtcctc cggtcgcgtg
    25741 cccggcgggt agatcaggcc gcccgcgacg ctcgacgtgg tgtcgccgac ccggtccgcg
    25801 ctgagcaccg tcacggtgtg gcccgcttcg gcgagccgca gcgcgcacgt gagcccgacg
    25861 acaccgccac cgacgacacc gattctcata gcctgccacc ctttcccgtt ttcccgcgac
    25921 cgttccaccg gagcggcgca cgggtcaagc gatctgcgta ggctcggttc cgtggagcag
    25981 gggacaacgg aggcggccgt cgcgaaaacc gcgcgcggag cgaggcccgt cgcgatcact
    26041 tcggcggtgt gcgcgctcgc gatggtggcg ctcggcatcc cgttcgcggg cggcaccgcg
    26101 cccggcgcgg tcgaccgcgc cttccaggac tgggtcgccg gtgccttcga cggccaggcc
    26161 gagctgctcc ggctgttcgt ggtcgcgacc cagccgtacg tgctggtccc ggtgctcgcc
    26221 gtcgtcgcga tcgcgtgcgc gctggcccgc cgcggtcccg aactggccgt ggcgctggcc
    26281 gggcccgcga tcgcgatcgc gctcaacacc tgggtgctga aacccttgtt cgaccggcac
    26341 aacggcggca cgtacgccta tccgagcggg cacacggtga gcctggtgtc gacgctggtg
    26401 gtgctggtga tcgtggcgcg gcccggcgcg gccaccgcgc tgaccgccgc actcggcgcg
    26461 ctgctggtgc ccttcgccgc ggtcggcatg gtcgggctcg gcttccacta cctcaccgac
    26521 gtcgtcggcg gcacgctgtt cgcggtcgcc ttcgtgctcg ccgccttgct cgtcagccgg
    26581 gcgtacttcc ggcggcgtcc ctggccaacg cggtgagcct gctcgtggcg cgcaggtact
    26641 tcttgcggta accgccttcg agcatgtcgg cgccgaacag ctcgccgagc ccgacgccgg
    26701 agaccatcac cgggatcgcg cggtcgtaga tccggtcggc gaaggcgacc aggcgcagcg
    26761 ccaccatctg gtccggcgcc gggcgcacgt gtcgcaggtg cacccgcgac accccgtcga
    26821 cgaggcgccc gtaccgcgac gggtgcaggc tcgccaggtg cgcgcacaac gcgtcgaaat
    26881 cgtccacagt ggacccgtcg tgcgcctcgg cggagcgcgt cagctcgtcg tccgtcgcgg
    26941 gcggcggcgc gtcggggagg ccgcggtgcc ggtagtcggg accgtccacc ctgatcacgc
    27001 cgaaccggct cgacagcgac tggatctcgc gcaggaagtc ctcggcggcg aaccggcctt
    27061 cgccgagctt ctccggcagc gtgttcgacg tcgcggcgat gtgcaccccg gcgtccatca
    27121 gctcgcgcag caaccgcccg acgagcatgg tgtcgccggg gtcgtccagt tcgaactcgt
    27181 cgatcgcgag caggcggtgc tccgagagcc gccgcaccgc ttcggcgaat ccgagcgcgc
    27241 ccaccagatg ggtcagctcg acgaaggtgc cgtacgcctt ggggcccggc accgcgtgcc
    27301 acagcgacgc gagcaggtgc gtcttgccga cgccgaaacc gccgtcgagg tagacgccca
    27361 tcgggccagc cggagtgtcg tcgcgcgagc cgaacagcga ccggaaccgc gagcgcttcg
    27421 cctccttcac accggccgaa acgcgctccg cgaacgccga gcacgagcgg accgcctcgg
    27481 cctggctcgg ctcgtccggg ttgggcacgt aggtggagaa ccggaccgtg tcgaaccgcg
    27541 gcggcggcac cagcgccgtg atcagctcgt cggcgccgat ctcgggccgc cggtcggtca
    27601 gatgcgctgg ggacatgggc acgaccctag aaccagtgca ccaggtgacc cagactcgcc
    27661 ccgagtcgac gagaacctgg tcacgtgctg ggatggaggc gtgcagaccc tgtggccggc
    27721 accggcggga aacccggtgg acgacgacga actcgagcgc ctgtacggct acccggacgg
    27781 gctcaccagg ccgtgggtgc aggcgaactt cgtgtcctcg gcggacggcg ccgtcacggt
    27841 cgacgaccag tcggagggcc tctcgcaccc ggcggacaag cggatcttcc tgctcggccg
    27901 cgacctcgcc gacgtggtgc tcgtcggcgg cggcacggtg cgggcggagg gctaccgcgg
    27961 cgtacggacc aacacgacgc gacgggcccg ccgcgaccgg ctcgggctgt cgccgatccc
    28021 gccgatcgcg gtggtcaccg gcagcgcggg gatcagcccc gattcgccgc tgctgaccga
    28081 caccgaggta ccgccgatca tcatcaccac cgacgccgcc gccgcggagc gcaagcggac
    28141 gctggccgcc gccggtgccg aaatcctcgt cgcgggcgag cagaaggtgg acctgaccgc
    28201 ggcgctcgcc accctggcga gcagggggct gcgccgcgtc gactgcgaag gcggcccgca
    28261 cctgctagcg gagttgatcg ccgaggacct cgtcgaccag ctctgcctga ccgtcgcccc
    28321 gctgctcgcg ggcggcggcg ccggccggat cgcgatcggc cggacctcga ccgcgccccg
    28381 gtccatggaa ctggcctcgg tgctgctcga agacgggttc accatgctcc gctaccggaa
    28441 accggggcca ccggcttgac ccccctgtcc gacgaggcgc tgctggccaa ggccgtcaaa
    28501 ggcgaccagg gcgccttcga cctgctggtg cgcaggcaca ccccgaggat gtaccgggtc
    28561 gcgctgcgga tcaccgggtc ggcggccgag gccgaggacg tggtgcagga cgcgtggatc
    28621 tccgcgtggc gcgcgctcgc cgggttccgc ggtgacgccg cggtgtcgac gtggctctac
    28681 cgcgtggtca cgaacgccgc gctcggccag gtccggcggc gcaggcccac cgtgtcgctc
    28741 gacgccgcga tggcaccggg cgaccagggc gggagcggcg cggcgttcga aggcgccgcc
    28801 ttcgccgaca ccgcggcgaa ccccgagggc aaggtggtgc gcgcggaaca ggtcgaagcc
    28861 gtgctgcggg cgatcgccac gctggacgtt tcccagcggg tgccactggt cttgcgcgaa
    28921 ctggaaggac tgagctacga ggaggtagcc gacgtgctgg aggtgagcgt gcccgcactc
    28981 cggtcccgcc tgcaccgagc acgggtggca ctgctcgcga agttgaggga actccgatga
    29041 cccccgccga agagacgacc gaggacccgc ggaacgaccc gaactgggcc ctggtccgcg
    29101 cggcggccga ggcacccgtg ccgacgccgc cgggcctcat cgcgcgcgtg ctgcactcgg
    29161 tgcacggact gcgggggcgc gtgttcggcg ccgccgtgga gttcccgtcc gagcagggca
    29221 ccctgcgggt gagcgagcgc gtgctggtgc tgctcgcgcg gcggctggcc gcggggatcg
    29281 gccaggagat cggcggggtg cacgtctcgg cggccgcgct cgacgaggac ggcctgcagg
    29341 tcctgctcac cgtgcggtac ggggtcgccg cgggcgaggc gtcggccgtg ctgcgcgccc
    29401 gcctgcacgc ggcgctcacc gatcagctcg gcgggacggc gccgccggtg accgtgcaca
    29461 tcgtggacgt ccaccccgac tgagactcac ccgttcggag gaacttgcga cagaagtcga
    29521 gtgaccgcga catcgtaggg aaagcacccc acgtaacaca cccgtaccac tgacctcggc
    29581 cccttcaggc cgtcggaagg agcacagtcc atggcacaga ccgcttcagg cgatcgcggc
    29641 acgccaccgg cgaagatcgc cgggcagagc gcggcgctca acgaagaagg ggcgctcggc
    29701 aagaccacca tctcctcgac ggtggtgcag aaggtcgccg gtgtct
//
