LOCUS       NZ_CP059997            46702 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Amycolatopsis sp. CA-230715 chromosome, complete genome.
ACCESSION   NZ_CP059997
VERSION     NZ_CP059997.1
KEYWORDS    RefSeq.
SOURCE      Amycolatopsis sp. CA-230715
  ORGANISM  Amycolatopsis sp. CA-230715
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
REFERENCE   1  (bases 1 to 10363158)
  AUTHORS   Jorgensen,T.S., Gren,T., Oves-Costales,D., Ortiz-Lopez,F.J.,
            Carretero-Molina,D., Gonzalez,I., Blin,K., Genilloud,O. and Weber,T.
  TITLE     Complete Genome Sequence of Amycolatopsis sp. CA-230715, Encoding a
            35-Module Type I Polyketide Synthase
  JOURNAL   Microbiol Resour Announc 10 (38), e0080521 (2021)
   PUBMED   34553997
REFERENCE   2  (bases 1 to 10363158)
  AUTHORS   Joergensen,T.S.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2020) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 19-JUN-2019
            Assembly Method :: Flye v. 2.4.1-geb89c9e; Unicycler v. 0.4.8-beta;
            SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 300.0x
            Sequencing Technology :: Illumina MiSeq; PacBio RSII; Oxford
            Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:21:34
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,592
            CDSs (total)                      :: 9,498
            Genes (coding)                    :: 9,434
            CDSs (with protein)               :: 9,434
            Genes (RNA)                       :: 94
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 82
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 64
            CDSs (without protein)            :: 64
            Pseudo Genes (ambiguous residues) :: 0 of 64
            Pseudo Genes (frameshifted)       :: 10 of 64
            Pseudo Genes (incomplete)         :: 60 of 64
            Pseudo Genes (internal stop)      :: 2 of 64
            Pseudo Genes (multiple problems)  :: 8 of 64
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 164752
            Orig. end                         :: 211454
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP059997.1.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            Bacteria and source DNA available from Fundacion MEDINA, Grenada,
            Spain.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..46702
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NRPS"
                     /region_number="2"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..46702
                     /SMILES="NCC(=O)NC(CO)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..46702
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[20000:26702](-)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(20001..26702)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     misc_feature    218..230
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     misc_feature    462..476
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.5"
                     /tool="antismash"
     misc_feature    552..566
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.96"
                     /tool="antismash"
     misc_feature    1279..1294
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.67"
                     /tool="antismash"
     gene            complement(2076..4025)
                     /locus_tag="HUW46_RS00770"
                     /old_locus_tag="HUW46_00156"
     CDS             complement(2076..4025)
                     /EC_number="4.2.1.3"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457529.1"
                     /locus_tag="HUW46_RS00770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00156"
                     /product="aconitate hydratase"
                     /protein_id="WP_215545413.1"
                     /transl_table=11
                     /translation="MASTVADQLITEHLVAGEPVAGEEIALRVDQTLTQDATGTLVMQE
                     LEALGLDRARTELSAQYVDHNLLQADEKNAEDHEFLRSACRRYGLWFSKAGNGVSHPTH
                     MQRFGVPGKTMIGSDSHTCAAGSLGMLAIGVGGLEVAMAIAGEPLYLRMPEIWGVRLTG
                     RLPDWVSAKDVVLEMLRRHGVKGGLNRIIEYHGPGLATLTAMDRHVIANMGAELGATAT
                     VFPADDAVREFLAAEGREDDFRALAADENAAYDHEDEIDLSTVEPLVARPSAPDNVVPV
                     REVAGTPISQVVLGSSANPGLRDFAIAAAMVRGRQTSDGVSFDVNPSSREIFADLTKMG
                     ATTDLVTAGARIHQSGCMGCIGMGQAPAKGRNSLRTFPRNFPGRSGTKEDSVWLCSPET
                     AAASALTGVLTDPRDFAAEAGLAYPVLALPAEATVNTKMLMPPLPPERARDEELVKGPN
                     ISSLPDFPALPGRIEAPVLLKLGDNVSTDEISPAGARALPFRSNVPKLAEFTFTPVDED
                     YPAKAREIADGSGHFIVAGENYGQGSSREHAAITTRHLGLRAVVAKSFARIHWQNLANF
                     GVLALEFTEHEDYDRIDDGDTLVLEDLRDLGSRTEITLRDTTKGEEYRLRHRLSERQVE
                     AVLAGGRIPLLARS"
     gene            complement(4079..5650)
                     /locus_tag="HUW46_RS00775"
                     /old_locus_tag="HUW46_00157"
     CDS             complement(4079..5650)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (93-262). E-value:
                     2.5e-15. Score: 48.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00775_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="HUW46_RS00775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00157"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_215545414.1"
                     /sec_met_domain="PF00561 (E-value: 5.2e-21, bitscore: 74.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTALGERMHKFRTAVLAAALGTTLATTVAPAEATPKPSLSFDAC
                     PGDLATPYPGMTCASVQVPLDYAAPEKGQLTLLVSKVPARDPAKRRGALFVNPGGPGAG
                     AASYVGKLTKPDGKGATRLPPSVLDSYDIIGMDPRGVGHSSPFACVDPGYFGGPQPDPD
                     ATAGQEKLWQTWTKFAAGCQAKAGAVLPHLGTVNVAKDMDLVREKMGERKLSYLGFSYG
                     TYLGAVYGELFGPKIDRMILDGNVNPEPEDLWYQAGLTQPPAVQKRVTDWLTWVAKYDS
                     VFHLGGSAAETTKAWNAALEDFRAHPHGSVGVNELLGLAFNVMFAEVGWEDLGRALSDY
                     AVKHDDSALVGMASPDATAAGVQKTSAFQSVICADSAWPADHAVYERDTAAVAKSSQFA
                     WYNTFTSGAACASWPVPHGTRAPVTGKGMPKILMFNSVGDPATPYAGAVKLHKALPGSV
                     LVTERDSGKHCVFANPIGYTNDRAQQLGAAYLTTGQLPPSDTTIAGHPVPGPSGTAAAE
                     PQRAPA"
     aSDomain        complement(4865..5371)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00775_Abhydrolase_1.1"
                     /evalue="2.50E-15"
                     /label="HUW46_RS00775_Abhydrolase_1.1"
                     /locus_tag="HUW46_RS00775"
                     /protein_end="262"
                     /protein_start="93"
                     /score="48.7"
                     /tool="antismash"
                     /translation="LFVNPGGPGAGAASYVGKLTKPDGKGATRLPPSVLDSYDIIGMDP
                     RGVGHSSPFACVDPGYFGGPQPDPDATAGQEKLWQTWTKFAAGCQAKAGAVLPHLGTVN
                     VAKDMDLVREKMGERKLSYLGFSYGTYLGAVYGELFGPKIDRMILDGNVNPEPEDLWYQ
                     AGLTQP"
     gene            5844..6575
                     /locus_tag="HUW46_RS00780"
                     /old_locus_tag="HUW46_00158"
     CDS             5844..6575
                     /NRPS_PKS="Domain: PKS_KR (4-164). E-value: 9.6e-15. Score:
                     46.9. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00780_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020420762.1"
                     /locus_tag="HUW46_RS00780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00158"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_215545415.1"
                     /sec_met_domain="adh_short (E-value: 2e-33, bitscore:
                     115.0, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.3e-30, bitscore:
                     104.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRVAIVTGSSRGIGRAIAERLGADGMDVLVNYRSDAAAAGEVV
                     AAIEASGGRATAVGADVTHLDRLREVFDAAERHYGGIDVVVSNVGIAKFAPVAEFTDED
                     YDTVFTTNALTTFRTLRESATRVRDGGRIVVVSSGVVATHSPGTAVYGASKAAGDALVR
                     VLAGELGARRVTVNSVLPGAVSTDALHSLRTPGELAAVAKRTPLGRLAEPGDIAGIVSF
                     LASDDARWITGQTVNAGGGYF"
     aSDomain        5856..6335
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00780_PKS_KR.1"
                     /evalue="9.60E-15"
                     /label="HUW46_RS00780_PKS_KR.1"
                     /locus_tag="HUW46_RS00780"
                     /protein_end="164"
                     /protein_start="4"
                     /score="46.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIVTGSSRGIGRAIAERLGADGMDVLVNYRSDAAAAGEVVAAIE
                     ASGGRATAVGADVTHLDRLREVFDAAERHYGGIDVVVSNVGIAKFAPVAEFTDEDYDTV
                     FTTNALTTFRTLRESATRVRDGGRIVVVSSGVVATHSPGTAVYGASKAAGDALVRV"
     CDS_motif       5862..5915
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00780_0001"
                     /evalue="4.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="HUW46_RS00780"
                     /protein_end="24"
                     /protein_start="6"
                     /score="9.8"
                     /tool="antismash"
                     /translation="IVTGSSRGIGRAIAERLG"
     CDS_motif       6234..6365
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00780_0002"
                     /evalue="5.40E+01"
                     /label="PKSI-KR_m1"
                     /locus_tag="HUW46_RS00780"
                     /protein_end="174"
                     /protein_start="130"
                     /score="-3.4"
                     /tool="antismash"
                     /translation="GRIVVVSSGVVATHSPGTAVYGASKAAGDALVRVLAGELGARRV"
     gene            6686..8686
                     /locus_tag="HUW46_RS00785"
                     /old_locus_tag="HUW46_00159"
     CDS             6686..8686
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499503.1"
                     /locus_tag="HUW46_RS00785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00159"
                     /product="glycoside hydrolase family 31 protein"
                     /protein_id="WP_215545416.1"
                     /transl_table=11
                     /translation="MRWRPLLCGATASLVLASAVTPAEAVEDGLTRAPGSVAFSVPRSL
                     GAPGYQLRIDIGRLGVTASRGGEPLLRTAPDAFTFGGGVATRVRSVTHRDGALVAVADS
                     TTGKTVTLRLTPKADRFDLRWSVDGEPDGDRATHFDLAASGQWYGGGETSEGKQQPYPL
                     SAGAVDEPEFSPASYMMQEPYFYTSKSVGVYVRTDQPMKVALGGGRADLTVTKAREYSS
                     TVFVESSRRAVYDDYVGEVGKPEKSDATDAEFASPLWNSWAQYYRDIDQDKVLKWADDL
                     KAAGVTGHTIQLDDKWESNYGNLTFDAKTFPDPKSMVDKIHGMGQKFGLWTTFWINLDS
                     ANYAYARDHGYLVRSKEDPAKPCTVKWWNGTAGIIDLANEAARNWYTGNLHCLMSKYGV
                     DGFKFDTRFFDDSCATSNGLTPRDYQKLGADMADGFDQQGVGIRTHWGNQRYGFVIRAV
                     DADASWGGLRTSLRRSMAISGNGYPFVETDMIGGSNSNPPPSPEVLVRWAQAASLMPLM
                     YSSTSPVSTIDTTTGKPVTYPAETAKYYAEAVRTHAKLAGYLKTQVRQAVADGSPIMRP
                     VFFDFPGDHRFDTIDDEWMLGPALLAAPKITEGASRDVVLPAGLWWDPAAKRLVFGGRT
                     LHGYPAPLGTTPMFVRIGAPGSASLIADLTR"
     gene            complement(8675..9901)
                     /locus_tag="HUW46_RS00790"
                     /old_locus_tag="HUW46_00160"
     CDS             complement(8675..9901)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021134.4"
                     /locus_tag="HUW46_RS00790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00160"
                     /product="glycosyltransferase 87 family protein"
                     /protein_id="WP_215545417.1"
                     /transl_table=11
                     /translation="MHRYRAVVVFLVLEIAVLGAVLLLRGFPGMDLEVYLGGARALAAD
                     GDPYLGKVLTSQGVHLPFTYTPFAAAVFLLGTLTPLKLTLIAMNVASIIGLGIVVYLVQ
                     VADGRRRRTAAAVALVAQLGAALIEPVLATLNYGQGNVFLMLAVVADVLVPWRRWPRGV
                     LVGLAAAVKLTPLVFCLFFLLRKDFRSLARTLGTFAGAGAVMWLVAPEASAKYWLHLMS
                     DTTRMGDLWFVSNQSLRGLLARAGMGLTTSTTLVWAALAVCALVLATGAITAALRAGRL
                     PLALVSCAQLGLLVSPVSWTHHWVWCAPAVVLLAWSARTRWTTDPFAARVLAAVSALAT
                     ILFLTGLPWLKPFPAGSVFSWLGAESYVLFGTLLLATVWWASARESAAKGLRDEPPGGG
                     ERLVAESAG"
     misc_feature    complement(9933..9947)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.81"
                     /tool="antismash"
     gene            10141..11211
                     /locus_tag="HUW46_RS00795"
                     /old_locus_tag="HUW46_00161"
     CDS             10141..11211
                     /EC_number="2.6.1.42"
                     /GO_function="GO:0004084 - branched-chain-amino-acid
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0009081 - branched-chain amino acid
                     metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_4 (89-336). E-value: 5.4e-26.
                     Score: 83.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00795_Aminotran_4.1"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019512408.1"
                     /locus_tag="HUW46_RS00795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00161"
                     /product="branched-chain amino acid aminotransferase"
                     /protein_id="WP_215545418.1"
                     /transl_table=11
                     /translation="MHDFPLRPAENALPAAERAAALADPGFGRTFTDHMATATWTPEQG
                     WHDRAVTALAPFSLHPSAAVLHYAQEIFEGLKAYRHADGGVRLFRPELNARRFAASARR
                     LALPELPEEAFLRSVEQLVRADEAWVPDGSDERSLYLRPYMFASEAFLGVRPAAEIRYA
                     VIASPAGAYFPAGVAGVTLWISTAYTRAAAGGTGAAKCGGNYAGGLAAQLEAKRHGCDQ
                     VLYLDSAHRSKLEESGTMNLCLVTEDRRLVTPGLGTILEGVTRDSVLALAEEHGLTPVE
                     RSVDLAELRAGEFTEVFATGTAAVITPIVGFRDEEGETVIGDGEPGKTTLALREHLLDL
                     QYGRIEDTRGWLRRVT"
     aSDomain        10408..11148
                     /aSDomain="Aminotran_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00795_Aminotran_4.1"
                     /evalue="5.40E-26"
                     /label="HUW46_RS00795_Aminotran_4.1"
                     /locus_tag="HUW46_RS00795"
                     /protein_end="336"
                     /protein_start="89"
                     /score="83.7"
                     /tool="antismash"
                     /translation="RPELNARRFAASARRLALPELPEEAFLRSVEQLVRADEAWVPDGS
                     DERSLYLRPYMFASEAFLGVRPAAEIRYAVIASPAGAYFPAGVAGVTLWISTAYTRAAA
                     GGTGAAKCGGNYAGGLAAQLEAKRHGCDQVLYLDSAHRSKLEESGTMNLCLVTEDRRLV
                     TPGLGTILEGVTRDSVLALAEEHGLTPVERSVDLAELRAGEFTEVFATGTAAVITPIVG
                     FRDEEGETVIGDGEPGKTTLALREH"
     misc_feature    complement(11287..11301)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.54"
                     /tool="antismash"
     gene            11386..11685
                     /locus_tag="HUW46_RS00800"
                     /old_locus_tag="HUW46_00162"
     CDS             11386..11685
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657436.1"
                     /locus_tag="HUW46_RS00800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00162"
                     /product="hypothetical protein"
                     /protein_id="WP_215545419.1"
                     /transl_table=11
                     /translation="MYIALQKYLEPEIEVDYSLAEHMIWLRKQFERGIFVAAGKCTTDS
                     GRVILVRPLGQDKLRAILATDPLVLRHLARYELVEFSPTRTADDLLGINEALAS"
     misc_feature    complement(11411..11426)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.19"
                     /tool="antismash"
     misc_feature    11461..11463
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(11762..12682)
                     /gene="lepB"
                     /locus_tag="HUW46_RS00805"
                     /old_locus_tag="HUW46_00163"
     CDS             complement(11762..12682)
                     /EC_number="3.4.21.89"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006465 - signal peptide processing
                     [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="lepB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020418156.1"
                     /locus_tag="HUW46_RS00805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00163"
                     /product="signal peptidase I"
                     /protein_id="WP_215545420.1"
                     /transl_table=11
                     /translation="MVEPLSQHASQNEPEPDEQAAPRSGRRRKAKKQRSFWVELPILIV
                     IALVLAFVFQQFFAKVYTIPSGSMESTLHGCTGCYGDKILVDKLVYDFTEPTPGEVVVF
                     KGPEPWVKNEALPEPSSNAFVRFLHTVGSAFGLAPPDERDFVKRVIATAGQTVQCCDAK
                     NRVVVDGKALDEPYLHWQSPSHQQQDTFPPITVPPNSLFVLGDNRNNSCDSRCQGDKRL
                     GGMVPVENVIGKARIIVLPPSRWGGVSDHNPQEKAQSTTVAAGLSAPSWQQGIPIGFGA
                     IAAWPVLAGGRRLFSGVRDKVKSKR"
     gene            complement(12804..13127)
                     /locus_tag="HUW46_RS00810"
                     /old_locus_tag="HUW46_00164"
     CDS             complement(12804..13127)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005467144.1"
                     /locus_tag="HUW46_RS00810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00164"
                     /product="hypothetical protein"
                     /protein_id="WP_215545421.1"
                     /transl_table=11
                     /translation="MSEPIPLFPEPTVDPAVFAEVQHDRFRGHNMRIGLSSAVHASADR
                     PWINGLTLLAPACHQGWSGLGSGELTPTRHEVTCLKCRRIRGLGRGDEAQYALFALPAT
                     GTG"
     misc_feature    13112..13126
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.0"
                     /tool="antismash"
     gene            complement(13173..16802)
                     /gene="metH"
                     /locus_tag="HUW46_RS00815"
                     /old_locus_tag="HUW46_00165"
     CDS             complement(13173..16802)
                     /EC_number="2.1.1.13"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0008705 - methionine synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032855.1"
                     /locus_tag="HUW46_RS00815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00165"
                     /product="methionine synthase"
                     /protein_id="WP_254125671.1"
                     /transl_table=11
                     /translation="MAGTASGEKALRELLDQRVVVLDGGWGTMLQNAGLTPADYRGDRF
                     GEHPKDVTGDPDLLNLTRPDVILDVHRQYLAAGADVTTTNTFTATSVGQADYGLESLVR
                     EMNLRAAELARQAADEAGGRFVAGSIGPLNVTLSLSPRVEDPAYRAVSFDQVHAAYAEQ
                     IEALAEGGVDVLLVETIFDTLNAKAAISAAREVAPHLPLWISVTIVDLSGRTLSGQTVE
                     AFWRSIEHASPLVVGLNCSLGAEEMRPHVAELSRLATTYTACYPNAGLPNAFGGYDQTP
                     GEMGQLLGDFAASGMANIVGGCCGTTPEHISAIASAVSGAATRPVPAPAARTRFSGLEP
                     WEMTEDTGFAMIGERTNVTGSARFRRLIEADDHQAAVDVALEQVRGGANVLDVNMDADL
                     LDSERAMTTFLNLIATEPEVARIPIMIDSSKWTVLEAGLKCVQGKGIVNSISLKEGEGP
                     FLEQARRIRDYGAGVVVMAFDEQGQADTADRKVEICARAYDLLTSEAGFPAEDIVFDPN
                     VLAVATGISEHNGYAKAFLDALPRIKQRCPGAHTSGGISNLSFSFRGNNVVREAMHSAF
                     LFHAVKAGLDMGIVNAGQLAVYQDIPADLLELVEDVLFDRRPDATDRLVTFAETVSGKG
                     TRREVDLSWRDAPVAERLSHALVHGIVDFIEDDTEEARQSLARPLEVIEGPLMDGMKIV
                     GDLFGAGKMFLPQVVKSARVMKRSVAYLEPFMEEEKEQARLAGTLVSGHGNGKVVLATV
                     KGDVHDIGKNIVGVVLGCNNYEVIDLGVMVPAAKILDTAVAENADVIGLSGLITPSLDE
                     MVNVAGEMQRRGLKRPLLIGGATTSRQHTAVRIAPAYDATTVHVLDASRVVGVVSDLLD
                     PERADGLDVANRAEQERLREQHANRQQRALLTYDQARANPERVPFDELPTPEFTGVRTV
                     RPALTELREMIDWQFFFLAWELKGKYPAILDQPVARELFDEGNALLDEIIEKGQFRAEG
                     AYGFWPAHSDGDDILLENGVGFPMLRQQTEKPTGRPNRCLADYVAPRGDHLGGFAVAIH
                     GAEELAARYEAEHDDYKAIMVKALADRLAEAFAEYLHLRARREWFEPGAEPALEDLHAE
                     RFRGIRPALGYPASPDHSLKQELFDLLDAGAIGMELTTSFAMTPAASVSGLIFAHPGSR
                     YFTVGRLGRDQIEDYAKRRGLDITEVERWLRPNLAYEPEGGTS"
     regulatory      complement(16817..16893)
                     /bound_moiety="S-adenosyl-L-homocysteine"
                     /db_xref="RFAM:RF01057"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF01057"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="S-adenosyl-L-homocysteine riboswitch; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(17062..20004)
                     /locus_tag="HUW46_RS00820"
                     /old_locus_tag="HUW46_00166"
     CDS             complement(17062..20004)
                     /NRPS_PKS="Domain: AMP-binding (6-387). E-value: 1.2e-103.
                     Score: 338.8. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00820_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (495-561). E-value: 3.3e-24. Score:
                     76.9. Matches aSDomain: nrpspksdomains_HUW46_RS00820_PCP.1"
                     /NRPS_PKS="Domain: nMT (616-837). E-value: 1.4e-91. Score:
                     298.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00820_nMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="HUW46_RS00820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00166"
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_215545422.1"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-108, bitscore:
                     360.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1e-10, bitscore:
                     41.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPCALFEEQVARTPEAVAVEFRGEHLTYAELDARAVRLAGHLVD
                     RGVGAGSIVGLVLPRSADLVVALLAVLKTGAAYLPIDPSYPRDRVSFILGDAGPQVVLT
                     TAVLRGRYPAELVLDELDLTGRPAALRTADPHPASAAYVIYTSGSTGTPKGVVVTRAGL
                     TNFLLAMRREFPLTAEDRLLAVTTIAFDIAGLELYLPLISGAAVVLAGDEEARDPDALR
                     RTVADDRITIMQATPALWQMVLTGPSFRNVTALVGGEALPPGLASAMTAASARVVNLYG
                     PTETTIWSSRHRVRDDAPSASLGEAIRNTRLYVLDEALRSVPEGELYIAGDGLARGYLH
                     RPGLTATRFVADPFGPPGSRLYRTGDLVRRERTLVFLGRADHQVKIRGFRIEPGEIESV
                     LAELPEVERAVVVAKEISAADRRLVAYLRPRPGCDLPPARSLVKHCARTLPGHMVPSVF
                     VEVPRFPLTDNGKLDRSALPEPVWAADVARRAPRTSQEEALCRAFSELLGVGEVGIDDD
                     FFDRGGHSLLGAQLVSRVRASHGVGMTMADLFERRTVARIATLLPAVTDAADGVGAPGS
                     LPDAAGQRLAEWRAIHDDHYAAGGGSDLGEDFSIWTSSYDGAPIPLADMREWRATTVAR
                     IRALRPRRILEIGVGSGLLLAHLAPHCESYWATDFSAPALDRLASQLAAVPRMAAKVTL
                     LNRAATDFTGVPAGSFDVVVVNSVVQYFPSGGYCEDVFDGCAAALRPDGELFVGDVRNL
                     RLLDCFHAGVAAARSATGPGGPTHAALFRRNLDLERELLIDPSFFTSYATAGHAFRSAA
                     LMLKRGTAHNELTRYRYDVVLSKKDTAKTAEVPVVRWRPGNSDVDGLPWWQGTAVPAEF
                     WVTGIPNARLAPDLAALAALTGHPRAEHDGVDPENLARAAEAAGYRVRAQPSDECDGRA
                     FDAYFRRETAAEQDYGPSAPGPAVLARHPDRYFNDPVDGGSHQSPAEARS"
     aSDomain        complement(17494..18156)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00820_nMT.1"
                     /domain_subtypes="nMT"
                     /evalue="1.40E-91"
                     /label="HUW46_RS00820_nMT.1"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="837"
                     /protein_start="616"
                     /score="298.7"
                     /tool="antismash"
                     /translation="GAPIPLADMREWRATTVARIRALRPRRILEIGVGSGLLLAHLAPH
                     CESYWATDFSAPALDRLASQLAAVPRMAAKVTLLNRAATDFTGVPAGSFDVVVVNSVVQ
                     YFPSGGYCEDVFDGCAAALRPDGELFVGDVRNLRLLDCFHAGVAAARSATGPGGPTHAA
                     LFRRNLDLERELLIDPSFFTSYATAGHAFRSAALMLKRGTAHNELTRYRYDVVLSKKD"
     CDS_motif       complement(17713..17736)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00820_0005"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="764"
                     /protein_start="756"
                     /score="-3.0"
                     /tool="antismash"
                     /translation="DCFHAGVA"
     misc_feature    complement(18274..18276)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(18322..18519)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00820_PCP.1"
                     /evalue="3.30E-24"
                     /label="HUW46_RS00820_PCP.1"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="561"
                     /protein_start="495"
                     /score="76.9"
                     /tool="antismash"
                     /translation="EEALCRAFSELLGVGEVGIDDDFFDRGGHSLLGAQLVSRVRASHG
                     VGMTMADLFERRTVARIATLL"
     aSModule        complement(18322..19986)
                     /complete
                     /domains="nrpspksdomains_HUW46_RS00820_AMP-binding.1"
                     /domains="nrpspksdomains_HUW46_RS00820_PCP.1"
                     /locus_tags="HUW46_RS00820"
                     /monomer_pairings="Gly -> Gly"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(18814..18879)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00820_0004"
                     /evalue="3.70E-13"
                     /label="NRPS-A_a8"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="397"
                     /protein_start="375"
                     /score="41.2"
                     /tool="antismash"
                     /translation="FLGRADHQVKIRGFRIEPGEIE"
     aSDomain        complement(18844..19986)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00820_AMP-binding.1"
                     /evalue="1.20E-103"
                     /label="HUW46_RS00820_AMP-binding.1"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="387"
                     /protein_start="6"
                     /score="338.8"
                     /specificity="substrate consensus: Gly"
                     /tool="antismash"
                     /translation="FEEQVARTPEAVAVEFRGEHLTYAELDARAVRLAGHLVDRGVGAG
                     SIVGLVLPRSADLVVALLAVLKTGAAYLPIDPSYPRDRVSFILGDAGPQVVLTTAVLRG
                     RYPAELVLDELDLTGRPAALRTADPHPASAAYVIYTSGSTGTPKGVVVTRAGLTNFLLA
                     MRREFPLTAEDRLLAVTTIAFDIAGLELYLPLISGAAVVLAGDEEARDPDALRRTVADD
                     RITIMQATPALWQMVLTGPSFRNVTALVGGEALPPGLASAMTAASARVVNLYGPTETTI
                     WSSRHRVRDDAPSASLGEAIRNTRLYVLDEALRSVPEGELYIAGDGLARGYLHRPGLTA
                     TRFVADPFGPPGSRLYRTGDLVRRERTLVFLGRADHQVKIR"
     CDS_motif       complement(18958..19032)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00820_0003"
                     /evalue="1.50E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="349"
                     /protein_start="324"
                     /score="46.0"
                     /tool="antismash"
                     /translation="GELYIAGDGLARGYLHRPGLTATRF"
     CDS_motif       complement(19528..19584)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00820_0002"
                     /evalue="4.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="159"
                     /protein_start="140"
                     /score="31.5"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGTPKGVVVT"
     CDS_motif       complement(19759..19800)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00820_0001"
                     /evalue="2.40E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="HUW46_RS00820"
                     /protein_end="82"
                     /protein_start="68"
                     /score="17.5"
                     /tool="antismash"
                     /translation="LAVLKTGAAYLPID"
     gene            complement(20001..26702)
                     /locus_tag="HUW46_RS00825"
                     /old_locus_tag="HUW46_00167"
     CDS             complement(20001..26702)
                     /NRPS_PKS="Domain: Condensation_LCL (2-290). E-value:
                     9.6e-81. Score: 263.0. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00825_Condensation_LCL.1"
                     /NRPS_PKS="Domain: PCP (585-654). E-value: 3.9e-26. Score:
                     83.0. Matches aSDomain: nrpspksdomains_HUW46_RS00825_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (668-965). E-value:
                     4.3e-99. Score: 323.2. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00825_Condensation_LCL.2"
                     /NRPS_PKS="Domain: AMP-binding (1131-1513). E-value:
                     2.9e-103. Score: 337.5. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00825_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1915-1983). E-value: 1.1e-21.
                     Score: 68.8. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00825_PCP.2"
                     /NRPS_PKS="Domain: Thioesterase (2002-2227). E-value:
                     2.3e-30. Score: 98.7. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00825_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="HUW46_RS00825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00167"
                     /product="non-ribosomal peptide synthetase"
                     /protein_id="WP_215545423.1"
                     /sec_met_domain="PP-binding (E-value: 2.2e-13, bitscore:
                     49.6, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 7.2e-61, bitscore:
                     205.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-103, bitscore:
                     346.2, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Thioesterase (E-value: 1e-22, bitscore:
                     80.6, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRLSSGQERMWLLQQMSSASSAYNARIALRFAGGVDDRALRRGL
                     DYLVARHAVLRSVFLADDEGSPYVAEADGFSIPITRETTDGDWRSVADPFVAVPFDLSA
                     APPAKGMLVTLPDGSAVLCLVFHHIVMDGRSFAVLTDELSTVYEAELRGEAPRLPGPAA
                     SYADYVCWQRENTDVESRLAYWRDELADARTLDLPLDFPRPAKFTAAGATSEFTLTADL
                     TAAFKAIALRWRCTVSSAMAGIFQAALAVHSGQDDVVIGAVLNGRQRTEFDDVIGLFVN
                     TVTLRTKVSPSMGFREFLRTAHATMTRAYTHQDVPFDQVVAELRPGRRTGRNPLFEVLY
                     IYQGEHAPRAEGTRTPERLPWLDVLTRFDIEFRVEIVDDRLTGTFIYRPELFRQDTADR
                     LGQLVRRLVELVVGDQDGSLLGADLYGGAPSEREVVGLGMTRLPEGIPGELYVSGSPTG
                     NLAVREPDGTARVLGRLEEWISLDGFRADTAEIERVVGEHPDVTRVAAVAHDDPNGERR
                     LICFISGTRDTAAVGRFTADRLPEYLVPAAFVALDTWPLDAHGRVRRADLPFPGKPLAG
                     MGRRPRTTREEVLCALFADVLKLPEVSIDDEFFELGGHSFLVAQLVSRVRAELGAELSI
                     RAVFDNPTVARLATTIDQAAGTRQPLAPRPSLDPTPLSFPQRRLWFHFQTQGADPTYNM
                     PLAMRLTGPLDRAALAEAFQDVITRHDALRTVFPSADGNPYQEVLGTRLELRYAEIAED
                     EVQDALDEAAQYPFDLIAEIPIRVWLWKTGRDDHTLLVLIHHIAGDGVSLAPFGRDLGH
                     AYQARVEGHSPQWTPLPVRYGDYSRWQLATLGDIRDGRKLAAKQGEYWREQLAGLPAEV
                     SPMADRSRSAQASMVGARIALELGPELHGRLRDVATSHHVSLNMVLNAGLAVLLAKLGC
                     GTDIPIGGVVAGRTEEALADLVGFFVNTIVLRYDLGGDPSFAELLARVRDVNLAAQDHQ
                     DLDFEQVVEIAAPARTLGRHPLFQVMLVFQGFDEGRVDLTGLTVRRRQVNVKVAKFDLH
                     FAFTERPDGQGVDCVLDYATDLYDRDTVERLLDRLVRVLTQVTADPGQSITAVDVLGDA
                     ERELMARWNATGAEIPPVTLTELLDRRMTADPDAEALVFEDERLTYAELDRRSGRLAMA
                     LRSRGAGVERVVAVALPRSIELIVALVAVVRSGAAYLPIEPDLPAGRRDAMITDAEPVF
                     VLDEETYRELSELPAGPYTPPGQHPRTPAYVLFTSGSTGRPKGVVIEHEAIVNRLLWMQ
                     AEFGLRPDDRVLQKTPAGFDVSVWEFFWAFVEGATLVVAAPGGHRDPRYLAGVLRAERI
                     TTIHFVPSMLQAFLTELGADPGTFDLRRVICSGEALSPALQHQYHQVMDAPLANLYGPT
                     EAAVDVTSWRCLPDTDATSVPIGAPVWNTRARVLDANLDAVAIGVPGELYLAGVQLARG
                     YRHNPRLTAERFVADPGGPPGTRMYRTGDLVRWTPAGQLQYLGRGDHQVKLRGVRIEPD
                     EISAAVAAHPAADQVAVAVHAPEPDVQRLVAYVVPNAGAAPGVRAIARWEETGEIDDLP
                     RHPLPNGRLVLGRNAAEIEYLYQEIFERKEYLRHGISVPDGATVLDVGAHVGMFSLFVG
                     TQARNVTIYAFEPIPELYREMVLNTSLNDIHTHAFPYGLSDRPGTADFVYYPQFSMLSG
                     QFGDLAEAGALAGSRIKRLAQGPGDFAALSGELEVLISQRLKERQEVTCELRTLSSVLD
                     EHAIAHVDLLKVDAENSELEVLAGVRDEHWARIDQVVVEVHDTGDRLAAVVDLLVGHGF
                     TTASETADLLVDSGLVNVFAVRPGSAAPVAAAADERWFDPDRFSADLRAIAGNLLTPAM
                     LPTDFVYLDRIPLSANGKLDRAALPAPKRVTVAGKAPSTPQEARLAELFARALDIESVG
                     VDGNFFELGGHSLVAAKLVGLIKESLGVELGVGAIFQAPTVTELGALIGHGGTGDAMDL
                     LMPIRTGGDGRPIFFLHPGIGLGWCYFGFGRHLRGNPLYTIQSRAVHGLDHMVLDIPAM
                     ATDYLEHVRSLQPHGPYRFVGWSFGGNIAHAMSTMLSDEGEEVELLAVLDSYPYAGTPP
                     GIASPDIAEVNPLHIALVRQCFPQMDAGETIEEERLALLAGILTRHQWLASHHEPGTHR
                     GDIVHFQAVGHPDEWRLNPHSWRDFISGEVRSHPMGVSHFDLLDADHLPLIADVIEAEL
                     RRVRS"
     aSDomain        complement(20022..20696)
                     /ASF="active site serine present: True"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00825_Thioesterase.1"
                     /evalue="2.30E-30"
                     /label="HUW46_RS00825_Thioesterase.1"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="2227"
                     /protein_start="2002"
                     /score="98.7"
                     /tool="antismash"
                     /translation="RPIFFLHPGIGLGWCYFGFGRHLRGNPLYTIQSRAVHGLDHMVLD
                     IPAMATDYLEHVRSLQPHGPYRFVGWSFGGNIAHAMSTMLSDEGEEVELLAVLDSYPYA
                     GTPPGIASPDIAEVNPLHIALVRQCFPQMDAGETIEEERLALLAGILTRHQWLASHHEP
                     GTHRGDIVHFQAVGHPDEWRLNPHSWRDFISGEVRSHPMGVSHFDLLDADHLPLIADVI
                     EAE"
     aSModule        complement(20022..24698)
                     /complete
                     /domains="nrpspksdomains_HUW46_RS00825_Condensation_LCL.2"
                     /domains="nrpspksdomains_HUW46_RS00825_AMP-binding.1"
                     /domains="nrpspksdomains_HUW46_RS00825_PCP.2"
                     /domains="nrpspksdomains_HUW46_RS00825_Thioesterase.1"
                     /final_module
                     /locus_tags="HUW46_RS00825"
                     /monomer_pairings="Ser -> Ser"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(20442..20516)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0020"
                     /evalue="2.10E-13"
                     /label="NRPS-te1"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="2087"
                     /protein_start="2062"
                     /score="42.5"
                     /tool="antismash"
                     /translation="QPHGPYRFVGWSFGGNIAHAMSTML"
     aSDomain        complement(20754..20957)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00825_PCP.2"
                     /evalue="1.10E-21"
                     /label="HUW46_RS00825_PCP.2"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="1983"
                     /protein_start="1915"
                     /score="68.8"
                     /tool="antismash"
                     /translation="EARLAELFARALDIESVGVDGNFFELGGHSLVAAKLVGLIKESLG
                     VELGVGAIFQAPTVTELGALIGH"
     CDS_motif       complement(22137..22199)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0019"
                     /evalue="1.50E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="1522"
                     /protein_start="1501"
                     /score="30.0"
                     /tool="antismash"
                     /translation="YLGRGDHQVKLRGVRIEPDEI"
     aSDomain        complement(22164..23309)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00825_AMP-binding.1"
                     /evalue="2.90E-103"
                     /label="HUW46_RS00825_AMP-binding.1"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="1513"
                     /protein_start="1131"
                     /score="337.5"
                     /specificity="substrate consensus: Ser"
                     /tool="antismash"
                     /translation="DRRMTADPDAEALVFEDERLTYAELDRRSGRLAMALRSRGAGVER
                     VVAVALPRSIELIVALVAVVRSGAAYLPIEPDLPAGRRDAMITDAEPVFVLDEETYREL
                     SELPAGPYTPPGQHPRTPAYVLFTSGSTGRPKGVVIEHEAIVNRLLWMQAEFGLRPDDR
                     VLQKTPAGFDVSVWEFFWAFVEGATLVVAAPGGHRDPRYLAGVLRAERITTIHFVPSML
                     QAFLTELGADPGTFDLRRVICSGEALSPALQHQYHQVMDAPLANLYGPTEAAVDVTSWR
                     CLPDTDATSVPIGAPVWNTRARVLDANLDAVAIGVPGELYLAGVQLARGYRHNPRLTAE
                     RFVADPGGPPGTRMYRTGDLVRWTPAGQLQYLGRGDHQVKLR"
     CDS_motif       complement(22284..22370)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0018"
                     /evalue="5.20E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="1473"
                     /protein_start="1444"
                     /score="47.5"
                     /tool="antismash"
                     /translation="IGVPGELYLAGVQLARGYRHNPRLTAERF"
     CDS_motif       complement(22884..22943)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0017"
                     /evalue="1.40E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="1273"
                     /protein_start="1253"
                     /score="33.0"
                     /tool="antismash"
                     /translation="AYVLFTSGSTGRPKGVVIEH"
     CDS_motif       complement(23649..23768)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0016"
                     /evalue="1.10E-17"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="1018"
                     /protein_start="978"
                     /score="56.3"
                     /tool="antismash"
                     /translation="RDVNLAAQDHQDLDFEQVVEIAAPARTLGRHPLFQVMLVF"
     aSDomain        complement(23808..24698)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00825_Condensation_LCL.2
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="4.30E-99"
                     /label="HUW46_RS00825_Condensation_LCL.2"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="965"
                     /protein_start="668"
                     /score="323.2"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIAGDG"
                     /tool="antismash"
                     /translation="PTPLSFPQRRLWFHFQTQGADPTYNMPLAMRLTGPLDRAALAEAF
                     QDVITRHDALRTVFPSADGNPYQEVLGTRLELRYAEIAEDEVQDALDEAAQYPFDLIAE
                     IPIRVWLWKTGRDDHTLLVLIHHIAGDGVSLAPFGRDLGHAYQARVEGHSPQWTPLPVR
                     YGDYSRWQLATLGDIRDGRKLAAKQGEYWREQLAGLPAEVSPMADRSRSAQASMVGARI
                     ALELGPELHGRLRDVATSHHVSLNMVLNAGLAVLLAKLGCGTDIPIGGVVAGRTEEALA
                     DLVGFFVNTIVLRYDL"
     CDS_motif       complement(23817..23906)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0015"
                     /evalue="4.30E-12"
                     /label="C5_LCL_267-296"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="962"
                     /protein_start="932"
                     /score="38.4"
                     /tool="antismash"
                     /translation="DIPIGGVVAGRTEEALADLVGFFVNTIVLR"
     CDS_motif       complement(24042..24089)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0014"
                     /evalue="7.90E-01"
                     /label="C5_LCL_267-296"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="887"
                     /protein_start="871"
                     /score="2.4"
                     /tool="antismash"
                     /translation="SPMADRSRSAQASMVG"
     CDS_motif       complement(24186..24209)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0013"
                     /evalue="3.70E-02"
                     /label="C4_LCL_164-176"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="839"
                     /protein_start="831"
                     /score="7.0"
                     /tool="antismash"
                     /translation="YGDYSRWQ"
     CDS_motif       complement(24261..24326)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0012"
                     /evalue="2.10E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="814"
                     /protein_start="792"
                     /score="23.5"
                     /tool="antismash"
                     /translation="IHHIAGDGVSLAPFGRDLGHAY"
     CDS_motif       complement(24519..24635)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0011"
                     /evalue="5.80E-20"
                     /label="C2_LCL_024-062"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="728"
                     /protein_start="689"
                     /score="63.7"
                     /tool="antismash"
                     /translation="PTYNMPLAMRLTGPLDRAALAEAFQDVITRHDALRTVFP"
     CDS_motif       complement(24660..24686)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0010"
                     /evalue="3.90E-01"
                     /label="C1_LCL_004-017"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="681"
                     /protein_start="672"
                     /score="4.3"
                     /tool="antismash"
                     /translation="SFPQRRLWF"
     aSDomain        complement(24741..24947)
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00825_PCP.1"
                     /evalue="3.90E-26"
                     /label="HUW46_RS00825_PCP.1"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="654"
                     /protein_start="585"
                     /score="83.0"
                     /tool="antismash"
                     /translation="EEVLCALFADVLKLPEVSIDDEFFELGGHSFLVAQLVSRVRAELG
                     AELSIRAVFDNPTVARLATTIDQA"
     aSModule        complement(24741..26696)
                     /domains="nrpspksdomains_HUW46_RS00825_Condensation_LCL.1"
                     /domains="nrpspksdomains_HUW46_RS00825_PCP.1"
                     /incomplete
                     /locus_tags="HUW46_RS00825"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(24912..24953)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0009"
                     /evalue="3.30E-02"
                     /label="Cy4"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="597"
                     /protein_start="583"
                     /score="7.4"
                     /tool="antismash"
                     /translation="TREEVLCALFADVL"
     CDS_motif       complement(25227..25289)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0008"
                     /evalue="2.20E-02"
                     /label="NRPS-A_a8"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="492"
                     /protein_start="471"
                     /score="7.8"
                     /tool="antismash"
                     /translation="LGRLEEWISLDGFRADTAEIE"
     CDS_motif       complement(25680..25796)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0007"
                     /evalue="1.40E-16"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="341"
                     /protein_start="302"
                     /score="52.8"
                     /tool="antismash"
                     /translation="HATMTRAYTHQDVPFDQVVAELRPGRRTGRNPLFEVLYI"
     aSDomain        complement(25833..26696)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00825_Condensation_LCL.1
                     "
                     /domain_subtypes="Condensation_LCL"
                     /evalue="9.60E-81"
                     /label="HUW46_RS00825_Condensation_LCL.1"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="290"
                     /protein_start="2"
                     /score="263.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: HHIVMDG"
                     /tool="antismash"
                     /translation="RLSSGQERMWLLQQMSSASSAYNARIALRFAGGVDDRALRRGLDY
                     LVARHAVLRSVFLADDEGSPYVAEADGFSIPITRETTDGDWRSVADPFVAVPFDLSAAP
                     PAKGMLVTLPDGSAVLCLVFHHIVMDGRSFAVLTDELSTVYEAELRGEAPRLPGPAASY
                     ADYVCWQRENTDVESRLAYWRDELADARTLDLPLDFPRPAKFTAAGATSEFTLTADLTA
                     AFKAIALRWRCTVSSAMAGIFQAALAVHSGQDDVVIGAVLNGRQRTEFDDVIGLFVNTV
                     TLRTKVS"
     CDS_motif       complement(25845..25934)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0006"
                     /evalue="1.70E-10"
                     /label="C5_LCL_267-296"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="286"
                     /protein_start="256"
                     /score="33.3"
                     /tool="antismash"
                     /translation="DVVIGAVLNGRQRTEFDDVIGLFVNTVTLR"
     CDS_motif       complement(25944..26000)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0005"
                     /evalue="5.20E+00"
                     /label="Cy4"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="253"
                     /protein_start="234"
                     /score="0.6"
                     /tool="antismash"
                     /translation="CTVSSAMAGIFQAALAVHS"
     CDS_motif       complement(26181..26210)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0004"
                     /evalue="6.60E-04"
                     /label="C4_LCL_164-176"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="174"
                     /protein_start="164"
                     /score="12.4"
                     /tool="antismash"
                     /translation="YADYVCWQRE"
     CDS_motif       complement(26262..26327)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0003"
                     /evalue="3.60E-09"
                     /label="C3_DCL_135-156"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="147"
                     /protein_start="125"
                     /score="29.1"
                     /tool="antismash"
                     /translation="FHHIVMDGRSFAVLTDELSTVY"
     CDS_motif       complement(26523..26639)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0002"
                     /evalue="1.10E-10"
                     /label="C2_DCL_024-062"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="60"
                     /protein_start="21"
                     /score="33.8"
                     /tool="antismash"
                     /translation="SAYNARIALRFAGGVDDRALRRGLDYLVARHAVLRSVFL"
     CDS_motif       complement(26658..26690)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_HUW46_RS00825_0001"
                     /evalue="1.80E-01"
                     /label="C1_LCL_004-017"
                     /locus_tag="HUW46_RS00825"
                     /protein_end="15"
                     /protein_start="4"
                     /score="5.2"
                     /tool="antismash"
                     /translation="SSGQERMWLLQ"
     gene            complement(26717..28003)
                     /locus_tag="HUW46_RS00830"
                     /old_locus_tag="HUW46_00168"
     CDS             complement(26717..28003)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="HUW46_RS00830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00168"
                     /product="MFS transporter"
                     /protein_id="WP_215545424.1"
                     /transl_table=11
                     /translation="MTGIPTGWRRYVGVGIGRSSWLLVACQTFYFMGISIDLTLTGVVG
                     LALAPTPALATLPLATITIAGTVCSFIAGFLTASIGYVRVMITGAIAAMVGAALSVIAV
                     STHDFPLLCCGTALVGAYRSTGGYIRYMAADRAPSGQRERVLSFVLYGGLLAAFIGPFV
                     ATTSSAFFGAQYAGSYFMVGVYAMLNIPLLLAIRASGVRAKTDGEKPVPVPLAEVRGTR
                     QFITGLLALAGSGAMMTMIMAVGPLGSQHAGHSSSMGATIIQWHLVGMFAPAVFSGNIV
                     ARIGPARTSVIGAALFVVAAIAGLGGDGFVNFLIALTLNGVGWNFLYLAGTTLLVRCYP
                     RGRGGRIQAVAEGIGSVTGVAASLSASTVFYFLGWQGTNVPVLIIALALLVVLFVAALR
                     ARGDEVRAEEQPAGEAEQPAERPMDVQES"
     gene            complement(28000..29154)
                     /locus_tag="HUW46_RS00835"
                     /old_locus_tag="HUW46_00169"
     CDS             complement(28000..29154)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099565.1"
                     /locus_tag="HUW46_RS00835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00169"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_215545425.1"
                     /transl_table=11
                     /translation="MQLPTRFGCFTSPLHRPGTDPALLLKEDLRLAETLDELGFDEFWV
                     GEHHSGGWATLSSPELFIAAAAQRTRRIRFATGVLGLPYHHPFLVAERAVLLNHLTDGR
                     FVLGAGSGAYQADMHMLGIDPATTRDRLAQALEVIQRLLAGEVVSAETDWFRMDDARVQ
                     TRPVAGPIELVVASAATPFSMRLAGRLGISAMSHVAPPWGAIRAGQDIGVDRLPGQWEH
                     LENEAGRPVDRREWRLVVPVHVSDSVDQAKAELFDGWRFQRSDLYKDTLGVPIPTADVA
                     QQKAFDYTIEQGGIIAGSPSDCVRAITALAERVSGFGCLLLSLQDWAPEEARERSLRLF
                     AREVVPRLKGAVDGVAASQRWVAGHRAEFVASNASGRAARMASR"
     gene            complement(29172..30272)
                     /locus_tag="HUW46_RS00840"
                     /old_locus_tag="HUW46_00170"
     CDS             complement(29172..30272)
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="HUW46_RS00840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00170"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_215545426.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.5e-07, bitscore:
                     29.1, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.1e-26, bitscore:
                     89.0, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 4.9e-38, bitscore:
                     129.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPDELLGRVDEIVAAGITPELAAEHERGETYPLELVRRLCELGL
                     PALVTERPHRTELFCRAVERVATAWVAPAESVHLQALATCALARHGSPELREEFLARLR
                     QGRVIAGNCLSEPGAGSDLALIATTAEPDGDGYRLNGVKAWVGHAGVAGLLNVYARTGG
                     GGLGGITCFLVDTASPGVEVRRAEDKMGVRALPTAQIAFHDVRVPAGRVVGRVNRGMVA
                     AQSFFVQGRLGIAACAIGLAEAALTRAVTHARTREQFGAPVITFQGVGFLLADASIEIE
                     ASRQLLHHACREVDVGGGRSELLAAQAKVLATDTAMKVTANAVQVLGARGYTGAEPVER
                     WMREAKLFQIIEGTNQIQRAAIASRL"
     gene            complement(30262..30963)
                     /locus_tag="HUW46_RS00845"
                     /old_locus_tag="HUW46_00171"
     CDS             complement(30262..30963)
                     /GO_function="GO:0008839 - 4-hydroxy-tetrahydrodipicolinate
                     reductase [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017024.4"
                     /locus_tag="HUW46_RS00845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00171"
                     /product="dihydrodipicolinate reductase C-terminal
                     domain-containing protein"
                     /protein_id="WP_215545427.1"
                     /transl_table=11
                     /translation="MPEFVLGVVGATGRFGTAVRAECERQGVHIGLTASRAGWRESARV
                     SVLADTSVPDALPDTVEHCRNAGAALVYCVSTVSDDARRSLAELGRDQVVVLADNLSVG
                     HWMQTRLVRTIATMVASAGKRPRMSVHERHPVTKKDSPSASAKSLAAAWASAAPPELCG
                     GTTAQRSGQPVSDHAVTFDLPGMSLSITHSVSDLRAAATGLVDVARYARGLAPGLYPVF
                     DVYSRMYGDGT"
     gene            complement(30956..31216)
                     /locus_tag="HUW46_RS00850"
                     /old_locus_tag="HUW46_00172"
     CDS             complement(30956..31216)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS00850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00172"
                     /product="hypothetical protein"
                     /protein_id="WP_215545428.1"
                     /sec_met_domain="PP-binding (E-value: 9.7e-05, bitscore:
                     21.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYTDSELSDQVADLIVESSGGVVTGEQVWDESANLLEKGFSSLS
                     FLQLIDSLETTYGVYIDVEADTQFLGRVSTIVGFLREQNVA"
     gene            complement(31226..32644)
                     /locus_tag="HUW46_RS00855"
                     /old_locus_tag="HUW46_00173"
     CDS             complement(31226..32644)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (31-373). E-value: 5.3e-32.
                     Score: 102.8. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00855_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="HUW46_RS00855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00173"
                     /product="class I adenylate-forming enzyme family protein"
                     /protein_id="WP_215545429.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-30, bitscore:
                     104.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGKLFHALATSLAAHQEAVVGSLAERVHGPDLLTRADAKRARLD
                     EVVAPAARVAVIRRNSPGYVSDLLAVLGGGHVPFLMDPSLGTSELAKLFADCGIDAVLH
                     DEVPKLPPVGGTVAHAGTRLSPTGRAGARPDLLPDTELCRLTSGSTRTPGCIEFSGAAV
                     LGAAEGWRVASGMSEEDRILCFAGLYNGLGFNAALIPGLLAGASIHLPAGLPTAGNIRR
                     HLTAVDPTVLVAFPAAYDSLAGSGGAGIRGHRPRLALSSAARLAPDTSAALARHGIRIA
                     DYYGIAETGPLTFNPDPVPGGGQGYPLPGVSLRFENGTLLAKSPSMGSRYLNYPGALED
                     RITESGHYRSSDQGSLTGRGELVLGERVDDSFSVGGKKFTAAEVEDLLGGHPEIDACSA
                     TMVAAGTGRPYLGAIVVARGAIDVVALRRYCLDRAAPFKVPERIVQVPEIPRNGAGKTQ
                     RAEVARLLAQRTDD"
     aSDomain        complement(31526..32551)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00855_AMP-binding.1"
                     /evalue="5.30E-32"
                     /label="HUW46_RS00855_AMP-binding.1"
                     /locus_tag="HUW46_RS00855"
                     /protein_end="373"
                     /protein_start="31"
                     /score="102.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DLLTRADAKRARLDEVVAPAARVAVIRRNSPGYVSDLLAVLGGGH
                     VPFLMDPSLGTSELAKLFADCGIDAVLHDEVPKLPPVGGTVAHAGTRLSPTGRAGARPD
                     LLPDTELCRLTSGSTRTPGCIEFSGAAVLGAAEGWRVASGMSEEDRILCFAGLYNGLGF
                     NAALIPGLLAGASIHLPAGLPTAGNIRRHLTAVDPTVLVAFPAAYDSLAGSGGAGIRGH
                     RPRLALSSAARLAPDTSAALARHGIRIADYYGIAETGPLTFNPDPVPGGGQGYPLPGVS
                     LRFENGTLLAKSPSMGSRYLNYPGALEDRITESGHYRSSDQGSLTGRGELVLGERVDDS
                     FS"
     gene            complement(32641..33831)
                     /locus_tag="HUW46_RS00860"
                     /old_locus_tag="HUW46_00174"
     CDS             complement(32641..33831)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="HUW46_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00174"
                     /product="nitroreductase family protein"
                     /protein_id="WP_215545430.1"
                     /transl_table=11
                     /translation="MPRTDTTGAISWADVSHPYLPATSSFSAVPEALERVIAQIEFAVG
                     ARPGSGKRAAPSAGACYPYEILLAPAGEPVIGVVDLARRRIVIDGAERHRWTGDAYTYF
                     LVGRPWLSMRRYGRRGYLYHLLDVGHALLNLALSVGRDRASWPDSLAAAREYALGHTGV
                     LLGFGTVLADTPRSAQPGWVVHEQSIVDIPVTDLECMIAELVPPPPAPVQVPALPGAGS
                     LAPGLGARRSAIALGTKADQDGLTGAVAEIQRLCERHIPAFDVPVPGITVFSRHPGVGA
                     EPPDRAWLAEALLGQQNLVEASTFLAIHGAIADTGPAALSEAAQRTLIGAGIAGELGYL
                     VAAREGLAVTGVGGFDPGRWAELCGTTDEVLFLLAFGYETASEKWDVASTGGNHSR"
     gene            complement(33875..34615)
                     /locus_tag="HUW46_RS00865"
                     /old_locus_tag="HUW46_00175"
     CDS             complement(33875..34615)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012804.4"
                     /locus_tag="HUW46_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00175"
                     /product="class II aldolase/adducin family protein"
                     /protein_id="WP_215545431.1"
                     /transl_table=11
                     /translation="MLRKTEETTAQAVDPLAVQAATGARMLSLGGHDDYNQGQISCRRP
                     GSVEFLIKGALTGFDEVTPREFVPAEIDPAATPDRLAPPEVPLHQAIYQARPDVNCVVH
                     SHAPDALVFGALAEELVPLSHEGALLRGEVDRFTLTSNTVLDIETGGEIAAALGSGIGV
                     FLVNHGSVVVGKTVRHAVIFALMLERACRLQLTALATGRDFATSSELDVEAKREFVFAD
                     LSIRAYWEHARRRVLRTFPESKTW"
     gene            34982..35734
                     /locus_tag="HUW46_RS00870"
                     /old_locus_tag="HUW46_00176"
     CDS             34982..35734
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00176"
                     /product="hypothetical protein"
                     /protein_id="WP_215545432.1"
                     /transl_table=11
                     /translation="MSSSGKAVLVVDFDFTGRPEANFGHFLELLELDRGIWQTTQPPAA
                     AREPVPAERYLDFWSQLPEAATGRVQALLGYCVGGAFLPALADRLEQAQDEPIDLVLFD
                     PEPVTVASLHDDFRKTVDLMSALSADEKTDLVANAREICVPEAEFTSAARKVSDLYRDA
                     VGTAFARLGLDESLSEEFVQVFQSYVSYLAAAAELSPQDGWGRGVALTSRESSPGAVHA
                     AEELNFLVRPGDLLGDPRVAEAVSRILR"
     gene            complement(36554..37570)
                     /locus_tag="HUW46_RS00880"
                     /old_locus_tag="HUW46_00177"
     CDS             complement(36554..37570)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013224.4"
                     /locus_tag="HUW46_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00177"
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_215545434.1"
                     /transl_table=11
                     /translation="MSSPVDDNAATLDCLDRQMIHALQVDGRAAFRRIAAVLGVSEQTV
                     ARRYRRLHGSGFLRVLGRLDPHRQGGTEWLIRVQARPNSARALADTIASYPQAVWVGLT
                     AGGSELVCTVRAPGEDGRNEILLERLPRTAQVLTIRSYAVLHRFDVGQLYWSGYPDLLD
                     SDQVAALAPARATTTPGPLRKGDEVLLHALAADGRRAYADLAAHTNWPRSRVVTRIAEL
                     RDSGALYFEVEFSPRIMGFQTTAYLWLNVTPSQLDSTGHALAEHPETAWVAAVAGPENL
                     VAVVIVRTHDELYRYINHRIGALQGVHTTEISLQLHQVKQADSLSNGDRLTALTPTS"
     gene            37639..39156
                     /locus_tag="HUW46_RS00885"
                     /old_locus_tag="HUW46_00178"
     CDS             37639..39156
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="HUW46_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00178"
                     /product="MFS transporter"
                     /protein_id="WP_215545435.1"
                     /transl_table=11
                     /translation="MRKWLPLIPISLGTVMFTVDITIIGMAIPAISDGLHVSFSALQWS
                     IDAYILVLAALVMAAGSASDRFGRLRVYLTGTLVFAIASLGCGLAPNAAVLIAGRALQG
                     VGAAAMMVTNTALLAGTYRGRDQGVAFGVWTSVTAVSAATGPLLGGVLTEALGWRSIFL
                     VNLPMALVALWTGRRWLPEGRDPAGGRIDVPGTALFVLAATLVTFALIRAGEDGWGSPS
                     VVPCLAAAAGALIAFGLVERHRRHPMLDLALLRKPAFVALLLGALVFNAASVADFVYRS
                     LWLQSIVHLDSFAAGLALTPMGAAALVTAMITGRLAATVEPRLPIGIGLLLISAGGFSY
                     LLLLTPDASWPALLPGLLITGAGVGVCSPVLASAVLATVPPSRAGMASGAMNTLLQLGF
                     ALGMPVLGTVLTATIRHTLTETGFADPEPAALAISNGRSPQLVAAFPPGDHGHVESMAR
                     AAFTTGLEQIFLCDGIAALAAGTVVLALMRRKRHHNTHSTTEATSPS"
     misc_feature    37657..37670
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    38698..38700
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            39358..40089
                     /locus_tag="HUW46_RS00890"
                     /old_locus_tag="HUW46_00179"
     CDS             39358..40089
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023776.4"
                     /locus_tag="HUW46_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00179"
                     /product="DUF3644 domain-containing protein"
                     /protein_id="WP_331477323.1"
                     /transl_table=11
                     /translation="MGRSDDEGLKKRFPNAADPVRLNVELFINLRNKIEHRYEPELKSM
                     TGGKAQALVVNYDAELTAAFGGKFSLADKLRFPVFLHALRPDGAEQLRAATANLPRPTR
                     DLVSRFETGIEQDLLDDLRYDFRIRLVPITGPKTSADLAVNFVKLDELSDEERRVMVDA
                     GRTGTVIVRDRHVDVVSKDKLLPGRVAQLVDSALPFEFSVNAHTKVWQHLRVRPPCGSL
                     KPHETDARYCLYDEPFGLYPA"
     misc_feature    39910..39912
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    39931..39933
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(40312..40638)
                     /locus_tag="HUW46_RS00895"
                     /old_locus_tag="HUW46_00180"
     CDS             complement(40312..40638)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00180"
                     /product="hypothetical protein"
                     /protein_id="WP_215545437.1"
                     /transl_table=11
                     /translation="MKVQVLHVPGCPGAEVLSEHLVRLSATWPGLRIDRRVVRDDQEAI
                     AAGMTGSPTLLIDGTDPFAEPAREPGIACRLYRHSDGSVDNAPSLAALRHVLAARREQE
                     GASR"
     gene            complement(40648..42705)
                     /locus_tag="HUW46_RS00900"
                     /old_locus_tag="HUW46_00181"
     CDS             complement(40648..42705)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1037: heavy metal
                     translocating P-type ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242799.1"
                     /locus_tag="HUW46_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00181"
                     /product="cation-translocating P-type ATPase"
                     /protein_id="WP_215545438.1"
                     /transl_table=11
                     /translation="MSDLCCGPEDSHAPEGAAAAETEAPQRLWQVREIQFAGIAGLLLL
                     AGFVCGWAGWEPGRIGGQLAAAAVGGWTFVPGTLTALVRGRIGVGTLMTIALAGSLVLG
                     QFAEAAMLAFLFSISEALEDYSISRTRRGLRALLALVPDQVRVLRDGRETTIAPTALRV
                     GDHMLVRAGDRLASDGTVRTGRSTMDNSAITGESVPVEAGPGDEVFAGAINGTGVLTVQ
                     ATATVEDNSLAKVVRVVADAQQRKGNRQRLADRIARPLVPAVLVLAALVAGIGELLGDP
                     VTWIERALVVLVAAAPCAMAISVPVTVIAAVGAASRFGVLVKGGAALEALGAVRTVALD
                     KTGTLTRNTPAVTEIVPAPDLTAERVLAVAAALEARSEHPLAAAILAAAPEPVPADEVT
                     TVPGAGLEGAVDGAAARLGKPGWIDPGPLAEDVARLQETGTTVAVIEHDHVVLGLIGIR
                     DELRPEAPETVTELRADGLGVAMLTGDNARTAAALATQAGIADVHAELRPTDKAALVER
                     LRERGAVAMVGDGVNDAPALATADVGIAMGAMGSDVAIDTADVALMGTDLRHLPQAVRH
                     ARRARGIMLQNIGLSAAIVLTLVPLAAFGILGLATVVFIHELAEVFVIGNGVRAGRLRP
                     LRGSTAPEPLTLQRIPATEADTEDGCACCAPNTEPAAQQITMQLSPPRNT"
     gene            complement(42702..43052)
                     /locus_tag="HUW46_RS00905"
                     /old_locus_tag="HUW46_00182"
     CDS             complement(42702..43052)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010242798.1"
                     /locus_tag="HUW46_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00182"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_215545439.1"
                     /transl_table=11
                     /translation="MSDDQCDLLCLDLDHAEALRTTLPGEAVLRQRADVLRALGDPTRL
                     RIAHALLAGDELCVCDLAWIVGSSQGLVSHHLRQLRSAGLAESRRDGKLVMYRLTGAGQ
                     HLLALAAEADPV"
     misc_feature    43100..43112
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            complement(43109..43624)
                     /locus_tag="HUW46_RS00910"
                     /old_locus_tag="HUW46_00183"
     CDS             complement(43109..43624)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HUW46_RS00910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HUW46_00183"
                     /product="hypothetical protein"
                     /protein_id="WP_215545440.1"
                     /transl_table=11
                     /translation="MAESSTSTTIPARGFARATCALRIFTGLVWLSNGLAKLLGTSNVD
                     LGFFSFNLITTDAARGIATNAASKTAIAPLGDFYRDIVLPNWETFAIVLTTAELAIGLG
                     TATRLAALGGLLLIGPIWIMLWHAGAYLWEYSAEDLFPLALLAFVPAGRVGGLDARLAL
                     RISGRWPF"
     gene            complement(43725..44243)
                     /locus_tag="HUW46_RS00915"
                     /old_locus_tag="HUW46_00184"
     CDS             complement(43725..44243)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013232.4"
                     /locus_tag="HUW46_RS00915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00184"
                     /product="hypothetical protein"
                     /protein_id="WP_215545441.1"
                     /transl_table=11
                     /translation="MWTTDLDRTEIGVVGMAVGAPFAVLVAEQLAASGADLVVSVTSAG
                     QIADLPHTPCFVLITDALRDEGTSLRYLPLGRWSHLDPTVADKLTGAPYRETTTAIDTA
                     REHGVLCVEMEAAALYAYARARGRTVVCLAHVTNAMAVDGDDFEKGVDNGVHSALAVVR
                     AVAATLLPT"
     gene            complement(44456..45619)
                     /locus_tag="HUW46_RS00920"
                     /old_locus_tag="HUW46_00185"
     CDS             complement(44456..45619)
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_5 (6-368). E-value: 1.6e-74.
                     Score: 242.9. Matches aSDomain:
                     nrpspksdomains_HUW46_RS00920_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005456494.1"
                     /locus_tag="HUW46_RS00920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00185"
                     /product="cysteine desulfurase family protein"
                     /protein_id="WP_254125673.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1e-69, bitscore:
                     234.3, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 0.00013,
                     bitscore: 20.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPGGPVYLDYNATTPVDPRVTDAAMPYWTEFFGNPSSDHPYADR
                     PRHALATAREQVAALLGARADEIVFTASGSEANLLALRGAVLGDGRGHLVIAATEHPAV
                     LQTAQALERLHGTEVTVLPVDHDGLLAPVALDAALVAGPGPAVVSIMAANNETGALQPI
                     TELATVAHRHGALVHCDAAQACGKIPVDVTESTVDLLTVVGHKMYAPRGAAALYVRDGV
                     ALEPVVYGGGQERGLRAGTENVALAVALGTAAQLAADDIATGAPQRIAALRDDLHDRLS
                     TALPGRIHLNGPVERRLPNTLNISIDRTRGHRVLTHAPEIAASTGSACHSGIHTPSPVL
                     TAMNLDTDRALAAIRLTLGRWSSSSDIDIAADALVRAVAHHDNEGIA"
     aSDomain        complement(44516..45601)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HUW46_RS00920_Aminotran_5.1"
                     /evalue="1.60E-74"
                     /label="HUW46_RS00920_Aminotran_5.1"
                     /locus_tag="HUW46_RS00920"
                     /protein_end="368"
                     /protein_start="6"
                     /score="242.9"
                     /tool="antismash"
                     /translation="VYLDYNATTPVDPRVTDAAMPYWTEFFGNPSSDHPYADRPRHALA
                     TAREQVAALLGARADEIVFTASGSEANLLALRGAVLGDGRGHLVIAATEHPAVLQTAQA
                     LERLHGTEVTVLPVDHDGLLAPVALDAALVAGPGPAVVSIMAANNETGALQPITELATV
                     AHRHGALVHCDAAQACGKIPVDVTESTVDLLTVVGHKMYAPRGAAALYVRDGVALEPVV
                     YGGGQERGLRAGTENVALAVALGTAAQLAADDIATGAPQRIAALRDDLHDRLSTALPGR
                     IHLNGPVERRLPNTLNISIDRTRGHRVLTHAPEIAASTGSACHSGIHTPSPVLTAMNLD
                     TDRALAAIRLTLGRWSSSSDID"
     gene            complement(45616..46287)
                     /locus_tag="HUW46_RS00925"
                     /old_locus_tag="HUW46_00186"
     CDS             complement(45616..46287)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007026653.1"
                     /locus_tag="HUW46_RS00925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HUW46_00186"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_215545443.1"
                     /transl_table=11
                     /translation="MVAEEATKARLYEAFAVSGKALANGTRLELLDLLAQGERTVDALA
                     SAAGLNLTTASAHLQTLKQAGFVTTRRDGVRVHYRLAGADVAQLFALLRKVAQAHQPAV
                     PAARDAFLGPGGDTEISRAQLRARAKAGEVVVLDVRPVHEYRAGHIPGAVSIPVHELAD
                     RVAELPEETEIVVYCRGEYCVLAYDAVRLLIDRGRRAIRLHDGMLEWRLAELPVAIGDR
                     A"
     misc_feature    complement(46012..46014)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gatcaccacg cacgggtatt cgctgccctg cgaacggtgg atgctcaccg cgtacgcgtg
       61 cgtcagctcg tccagttccg cgaactcgta gtcgacatcc tcgtcgtcat ccgtgcgcac
      121 caccagtttc tgctcttcca gccggacatc gacgaccacg ccctgggtgc cgttgaacac
      181 cccgttcgcg cccttgtcgt agttgttgcg catctgcgtg accttgtcgc ctggccggaa
      241 cacgcgcccg ccgaaacggc gttccggcac gccgtcgcgc gaaggcgtca gcgcttcctg
      301 cagcccgagg ttgagcgccc ccgcccccgc cgcgccccgg tgcatcggcg ccagcacctg
      361 gacgtcgcgg cgcgggttca ggccgaactt ggccgggatc cgccgcgcca ccacgtccac
      421 cgtcagcttc gccgcgtcct cggcgtcgtc gacgctgaac aggaagaagt cgtccagccc
      481 ctggacccgc gggtagtcac cggcgttgat ccggtgcgcg ttcgtcacca cgccggattc
      541 ggtggcctgc cggaagatcc ggttcagccg cacgtgcggg atcggcgtcc cggtcgcgag
      601 cagatcgcgc agcacctcac cggccccgac cgacggaagc tggtcgacgt cgccgacgag
      661 cagcacgtgc gtgccggggg cgatcgcctt tgcgagcttg ttcgccagca gcaggtccag
      721 catggacgct tcgtcgacca ccacgagatc cgcttcgagc ggccggtcct tgtcgtaggc
      781 ggcgtccccg cccggtttca gctccagcag ccggtgcacg gtcgccgcct cgtgcccggt
      841 cagctcggtg agccgcttcg ccgcgcgccc ggtcggcgcg gcgagcacca ccttcgcccg
      901 cttcgccttc gccagctcca caatggaccg gaccgtgaag ctcttgccgc agccgggacc
      961 gccggtcagc acggacacgc gttcggtcag cgcgagcttg accgcggcct cctgctcggg
     1021 cgccagctcg gcgccggtgg tcttcgcgag ccaggcgagc gccttcgtcc agtcgacctc
     1081 ggcgaacgcg ggcatccggt ccgccgaggt gcgcagcagg cgcgtgagct ggttcgcgag
     1141 cgcgatttcg gcgcggtgga agggaaccag gtagatcgcg cgcacatcct ccccgtcccc
     1201 gccggggatc cggtcggcga cgacaccctc ctcgtcgacg agttcggcga ggcagtcgat
     1261 caccagcccg gcgtcgacga tgagaatctt gatcgcctcg gcgatcagct cggtgtccgg
     1321 caggaagcag tgcccgttgc cggtggcctc ggacagcgtg aactgaaggc ccgctttgat
     1381 ccgctgtggg ctgtcgtgcg ggatgccgac ggccttcgcg atggtgtcgg cggtcttgaa
     1441 cccgatgccc cacacgtcac cggcgagccg gtacggctcg gtgcgcacga tttcgatcgc
     1501 ggtgtcggcg tactgcttgt agatccgcac ggcgagcgac gtcgacacac cgacgccctg
     1561 caggaagacc atcacctcct tgatggcctt ctgctcctcc cacgccgcgg cgatcagctt
     1621 cgtccgcttc ggcccgaggt tcggcacctc gatgagccgg tcgggggtct gctcgatgac
     1681 gtcgagcgcg tcgacgccga agaagtccac gatccgttcc gcgagcttcg gcccgatgcc
     1741 cttgatcagt cccgagccga ggtagcggcg gacgccctgc accgtcgcgg gcagcacggt
     1801 ggtgtagtcc tcgacgtgga actgcttgcc gtactgcgga tgtgaacccc agcggccgcg
     1861 catcttcagc gcctcgcccg gctgcgcgcc gagcagcgag ccgaccaccg tcaccaggtc
     1921 gccgccgcgg ccggtgtcca cgcgcgcgac ggtgtagccg gtctcctcgt tggcgaaggt
     1981 gatccgctcg agcgtcgcct ccagcagcgc tccccgaacc ggctccgtca cgacggccat
     2041 cttgccccgg cgccgccgga gcccgccacc aggcctcagg accgggcgag cagcgggatc
     2101 cggccgcccg cgagcaccgc ttccacctgg cgttccgaaa ggcgatggcg caggcggtac
     2161 tcctcgccct tcgtggtgtc gcggagggtg atctccgtgc gggaaccgag gtcccgcagg
     2221 tcttccagca cgagggtgtc gccgtcgtcg atacggtcgt agtcttcgtg ctcggtgaac
     2281 tcgagcgcca gcacgccgaa gttcgcgagg ttctgccagt ggatgcgcgc gaacgacttc
     2341 gccaccaccg cgcggaggcc gaggtggcgc gtggtgatcg cggcgtgttc gcgtgacgag
     2401 ccctggccgt agttctcccc cgcgacgatg aaatgccccg acccgtccgc gatctcgcgc
     2461 gccttcgccg ggtagtcctc gtcgaccggg gtgaaggtga actcggcgag cttcggcacg
     2521 ttcgaccgga acggcagcgc cctcgcgccc gcgggcgaga tctcgtcggt ggagacgttg
     2581 tcgccgagct tgagcagcac cggcgcctcg atccggccgg gcagtgccgg gaagtccggc
     2641 agcgaggaga tgttggggcc cttcaccaat tcctcgtcgc gagcccgttc cggcggcagc
     2701 ggcggcatca gcatcttggt gttcaccgtc gcctcggcgg gcaacgcgag caccgggtac
     2761 gcgagcccgg cctcggcggc gaagtcgcgc ggatcggtca ggacgcccgt caacgcagag
     2821 gccgccgccg tctccggcga gcacagccac accgagtcct ccttggtccc cgaccggccg
     2881 gggaagttgc gcgggaaggt gcgcagcgag ttccgtccct tcgcgggcgc ctgccccatt
     2941 ccgatgcagc ccatgcatcc cgactggtgg atccgcgcgc ccgccgtcac aagatccgtg
     3001 gtggcgccca tcttcgtgag atccgcgaag atctcgcgcg acgacgggtt gacgtcgaag
     3061 ctgacgccgt cgctggtctg ccttccccgc accatcgcgg ccgcgatcgc gaagtcgcgc
     3121 agcccggggt tcgccgagga gccgagcacg acctggctga tcggagttcc cgcgacctcg
     3181 cgcaccggca ccacgttgtc cggagcggac ggtcgcgcga ccagaggctc cacagtggac
     3241 agatcgattt cgtcctcgtg gtcgtaggcg gcgttctcgt ccgcggccag tgcgcggaaa
     3301 tcgtcctccc tgccttcggc ggcgaggaat tcgcgcacgg cgtcgtcggc ggggaacacg
     3361 gtcgcggtcg cgcccagctc ggcgcccatg ttcgcgatca cgtgccggtc catcgcggtg
     3421 agcgtggcga gaccgggccc gtggtactcg atgatccggt tgagcccgcc cttcacgccg
     3481 tggcgccgca gcatttccag cacgacgtcc ttcgccgaca cccagtccgg gagccgtccg
     3541 gtcaaccgga cgccccagat ctccggcatc cgcaggtaca gcggctcccc cgcgatggcc
     3601 atggcgactt cgagcccgcc gacgccgatc gcgagcatgc cgagcgaacc cgcggcgcag
     3661 gtgtgggagt ccgagccgat catcgtcttg ccgggcaccc cgaaccgctg catgtgcgtc
     3721 gggtgcgaaa ccccgttgcc cgccttggag aaccacaggc cgtagcggcg gcaggccgag
     3781 cggaggaact cgtggtcctc ggcgttcttt tcgtcggcct gcagcaggtt gtggtcgacg
     3841 tactgcgcgc tcagctcggt gcgggcgcga tcgagcccga gcgcctcgag ctcctgcatg
     3901 acgagcgtgc cggtggcgtc ctgggtgagg gtctggtcga cgcgcagcgc gatctcctcg
     3961 cccgccaccg gctcccccgc caccaggtgc tcggtgatca gctggtccgc gacggtcgaa
     4021 gccatgacaa cacctccccg gcacgggtac ccggctggag aggcgctcaa tccgttcctc
     4081 aggcgggcgc gcgctgcggc tcggccgccg cggtgcccga cggtcccggc accgggtgcc
     4141 cggcgatcgt ggtgtccgac ggcgggagct ggcccgtggt caggtacgcg gcgccgagct
     4201 gctgcgcgcg gtcgttggtg tacccgatcg ggtttgcgaa cacgcagtgc ttccccgaat
     4261 cgcgctcggt caccagcacg gagccgggaa gcgccttgtg cagcttcacc gcgcccgcgt
     4321 acggcgtggc cgggtcgccg acggagttga acatcaggat cttcggcatg cccttgccgg
     4381 tgaccggtgc ccgcgtcccg tgcggcaccg gccagctcgc gcacgccgca ccgctggtga
     4441 acgtgttgta ccaggcgaac tgcgagctct tcgcgaccgc ggcggtgtcc cgttcgtaca
     4501 cggcgtggtc ggccggccat gcggagtccg cgcagatcac cgactggaac gccgaggtct
     4561 tctgcacccc tgcggcggtg gcgtccggcg aagccatccc gacgagcgcg ctgtcgtcgt
     4621 gcttgaccgc gtagtcggac agcgcgcggc cgaggtcctc ccagccgacc tccgcgaaca
     4681 tcacgttgaa cgccagtccc agtagttcgt tcacgccgac ggaaccgtgc gggtgtgcgc
     4741 ggaagtcctc gagcgcggcg ttccacgcct tcgtggtctc ggccgcgctg ccgccgaggt
     4801 ggaacaccga gtcgtacttc gccacccagg tgagccagtc ggtcacgcgc ttctgcacgg
     4861 cgggcggctg cgtcagcccc gcctggtacc acaggtcctc tggctccggg ttgacgttgc
     4921 cgtcgaggat catccggtcg atcttcggcc cgaacagctc gccgtagacc gcgccgaggt
     4981 aggtgccgta ggagaagccg aggtagctca gcttgcgctc gcccatcttc tcgcggacga
     5041 ggtccatgtc cttcgcgacg ttcaccgtgc cgaggtgcgg cagcacggcg cccgccttcg
     5101 cctggcaccc ggcggcgaac ttcgtccacg tctgccacag cttttcctgg cccgccgtgg
     5161 cgtcgggatc cggttgcggg ccgccgaagt agccgggatc gacgcacgcg aacggcgagc
     5221 tgtgcccgac gccgcgcggg tccatgccga tgatgtcgta cgagtcgagc acgctcggcg
     5281 gcagccgggt cgcccccttg ccgtccggtt tcgtcagctt cccgacgtag gaggcggcac
     5341 ccgcgccggg gccaccgggg ttgacgaaga gcgcgccgcg ccgtttcgcc gggtcccgcg
     5401 cgggcacctt cgagaccagc agcgtgagct gccccttctc cggtgcggcg tagtccagcg
     5461 ggacctgcac gctcgcacag gtcataccgg ggtacggcgt ggcgagatca ccggggcagg
     5521 cgtcgaacga cagcgaaggc ttcggtgtcg cctccgccgg tgcgaccgtc gtcgccagcg
     5581 tcgtccccag cgccgcggcc agcacggccg tgcggaactt gtgcatgcgc tcccccagtg
     5641 cggtggtcat ctcggatcgg gtggccgttc gcaggttatc gacggaacgc gcgccgcgcc
     5701 gcccggctcg cccgttcagc gcagcacttc cccctggtac cagggaaaac gcccgtcgcg
     5761 gcacacgtcg atttcacccc gcctatattc gggtacggcc cggcaccagc gcggtccaca
     5821 gtggacgatc atggagggaa cacatggcga ggcgcgtcgc gatcgtgacc ggcagttcgc
     5881 gcgggatcgg gagggcgatc gcggaacggc tcggcgcgga cgggatggac gtgctcgtca
     5941 actaccgatc cgacgcggcg gcggcgggcg aagtcgtcgc ggcgatcgag gcgtcgggcg
     6001 ggcgcgccac ggccgtcggt gcggacgtca cccatctcga ccggcttcgc gaggtcttcg
     6061 acgccgccga acggcactac ggcggtatcg acgtcgtggt gagcaatgtc ggaatcgcca
     6121 agttcgcgcc ggtcgcggag ttcaccgacg aggactacga cacggtgttc accaccaacg
     6181 cgctcaccac cttccgcacg ctgcgggagt cggccacccg ggtgcgcgac ggcggccgga
     6241 tcgtcgtggt ctccagcggg gtcgtcgcga cgcactcgcc ggggaccgcg gtgtacggcg
     6301 cgagcaaggc ggcgggcgac gcgctggtcc gcgtgctggc cggggaactc ggcgcgcgcc
     6361 gggtcaccgt caacagcgtg ctgcccggcg ccgtgagcac cgacgcgctc cactcgctgc
     6421 ggacgccggg cgaactcgcc gccgtcgcca agcgcacccc gctcgggcgg ctcgccgaac
     6481 cgggcgacat cgccggcatc gtctcgttcc tcgcctccga cgacgcgcgc tggatcaccg
     6541 ggcaaaccgt caacgcgggc ggcggctact tctgacgcca tcaagggcat cgaacccagc
     6601 cttgacaacg cgggcttgac gcgttctgct tagtcctgac tttttggtgg cagtaacgcg
     6661 cacattcacg catctggagg catccatgcg ctggcgtccc ctgctgtgcg gtgcgaccgc
     6721 gagcctcgtg ctcgcgagcg ccgtcacgcc cgccgaggcg gtggaagacg ggctcacccg
     6781 ggcaccggga tccgtggcat tctcggttcc ccgcagcctc ggcgcgcccg gttaccagct
     6841 gcgcatcgac atcggccgcc tcggcgtgac cgcgtcccgc ggcggcgaac ccctcctgcg
     6901 caccgcgccg gacgccttca ccttcggcgg cggcgtggcc acccgggtcc gttcggtcac
     6961 gcaccgggac ggcgctctcg tcgcggtggc ggacagcacc accggcaaga ccgtcacgct
     7021 gcggctgacc ccgaaggccg accggttcga cctccgctgg tcggtcgacg gcgagccgga
     7081 tggcgaccgg gcgacgcact tcgacctcgc cgcatccggc cagtggtacg gcggcggcga
     7141 gacgagcgag ggcaagcagc agccgtaccc gttgtcggcg ggcgctgtcg acgaaccgga
     7201 gttctccccc gccagctaca tgatgcagga gccgtacttc tacacctcga aatcggtcgg
     7261 cgtgtacgtc cggaccgacc agccgatgaa ggtcgccctc ggcggagggc gcgcggatct
     7321 caccgtcacc aaggcgcgcg agtactcgag caccgtgttc gtcgagagca gccgccgcgc
     7381 ggtgtacgac gactacgtcg gcgaggtcgg caagccggag aagagcgacg ccaccgacgc
     7441 cgagttcgcc agtccactgt ggaattcgtg ggcgcagtac taccgggaca tcgaccagga
     7501 caaggtgctg aagtgggccg acgatctcaa ggcggccggc gtcaccgggc acaccattca
     7561 gctcgatgac aagtgggagt cgaactacgg caacctgacc ttcgacgcga agaccttccc
     7621 ggacccgaag tccatggtgg acaagatcca cgggatgggc cagaagttcg ggctgtggac
     7681 cacgttctgg atcaacctcg actccgcgaa ctacgcctac gcgcgggatc acggatatct
     7741 ggtgcgcagc aaggaagatc cggcgaagcc gtgcaccgtc aagtggtgga acggcaccgc
     7801 gggcatcatc gacctcgcca acgaggcggc acggaactgg tacaccggca acctccactg
     7861 cctgatgtcg aagtacggcg tggacgggtt caagttcgac acccggttct tcgacgacag
     7921 ctgcgccacc tcgaacggcc tcaccccgcg cgactaccag aagctcggcg cggacatggc
     7981 ggacgggttc gaccagcagg gcgtcgggat ccgcacgcac tggggcaacc agcgctacgg
     8041 gttcgtgatc agggccgtgg acgcggacgc cagctggggc gggctgcgca cgtcgctgcg
     8101 ccgctcgatg gccatctccg gcaacggcta cccgttcgtc gagaccgaca tgatcggtgg
     8161 gtcgaacagc aacccgccgc cgtcgccgga ggtactggtg cgctgggcgc aggcggcctc
     8221 gctgatgccg ctgatgtact cctccacctc accggtgagc acgatcgaca ccaccaccgg
     8281 caaaccggtg acctaccccg cggaaaccgc gaagtactac gccgaggccg tgcgcacgca
     8341 cgcgaagctg gcgggctacc tgaagaccca ggtgcggcag gcggtcgcgg acggcagccc
     8401 gatcatgcgg ccggtgttct tcgacttccc cggcgaccac cgcttcgaca cgatcgacga
     8461 cgagtggatg ctcgggcccg cgctgctcgc cgcaccgaag atcaccgaag gcgccagccg
     8521 cgacgtggtg ctgcccgccg ggctgtggtg ggatccggcc gcgaagcggc tcgtgttcgg
     8581 cggcaggacg ctgcacgggt acccggcgcc gctgggcacc accccgatgt ttgtccggat
     8641 cggcgcaccc ggctccgcat cgctgatcgc cgatctaacc cgctgattcc gcgacgagcc
     8701 gctctccgcc accgggcggc tcgtcgcgga gtcctttcgc ggcgctctcg cgcgcggacg
     8761 cccaccacac ggtggcgagc aagagcgttc cgaacaggac gtagctttcg gcgcccagcc
     8821 acgagaacac cgagcccgcg gggaacggct tcagccacgg cagcccggtg aggaacagga
     8881 tcgtggcgag cgcggacacc gcggcgagga ccctcgccgc gaacggatcg gtggtccagc
     8941 gggtgcgcgc cgaccacgcg agcaggacga ccgcgggcgc gcaccacacc cagtggtgcg
     9001 tccacgacac cggcgaaacc agcagcccca gctgcgcgca gctcaccagc gccagcggga
     9061 gccgtcccgc gcgcagcgcg gcggtgatcg ccccggtcgc gaggaccagc gcgcacacgg
     9121 ccaacgccgc ccacacgagc gtcgtcgagg tggtcaggcc catgcccgcg cgcgcgagca
     9181 ggccgcgcag cgactggttg ctgacgaacc acagatcgcc catgcgcgtg gtgtccgaca
     9241 tcaggtgcag ccagtacttc gccgacgcct ccggcgccac cagccacatc accgccccgg
     9301 caccggcgaa cgtgccgagc gtccgcgcga gtgagcggaa gtccttgcgc agcaagaaga
     9361 acaggcagaa caccagcggt gtcagcttga ccgcggcggc gagcccgacc aggaccccgc
     9421 gcggccaccg ccgccacggc acgagcacgt cggcgacgac cgcgagcatc aggaagacgt
     9481 tgccctggcc gtagttgagc gtggccagca ccggttcgat gagcgccgcg ccgagctggg
     9541 ccacgagcgc gacggctgcc gcggtgcgac ggcgcctgcc atcggcgacc tgcaccaggt
     9601 acaccacgat cccgagcccg atgatcgagg cgacgttcat cgcgatcagg gtgagcttca
     9661 gcggggtgag ggtgccgagc aggaacaccg ccgcggcgaa cggggtgtag gtgaacggca
     9721 ggtgcacgcc ctgcgaggtg aggaccttcc cgaggtacgg gtcgccgtcg gcggcgagcg
     9781 cgcgcgcccc gccgaggtag acctccaggt ccatgccggg gaacccgcgc agcagcagga
     9841 ccgcaccgag aacagcgatc tcgagcacga ggaacacgac gacagcgcga tatcggtgca
     9901 ccggatcatc caacaccgag gggcgcgggg acatcgccgc gggtaatggt tttgccccgc
     9961 ggcccggatc ggcgagactg agcgcgagcg gcgatccgcc gccgggccgg tgcacccggc
    10021 cactcggtgc ggtgcccggc gacgaactgg ccgggcggcc gccccggtat cgcggcggcg
    10081 gcaggcgaga tcctcgcggc aggcccccgc acgaaccggc ccatccgagt gaggacttcg
    10141 atgcacgact ttccccttcg ccccgccgaa aacgcccttc cggcggccga gcgcgccgcc
    10201 gcgctggccg atcccgggtt cggcaggacg ttcaccgacc acatggcgac cgccacctgg
    10261 acccccgagc agggctggca cgaccgcgcg gtgacggcgc tggcgccgtt ttccctgcac
    10321 ccgagcgcgg ccgtgctgca ctacgcgcaa gagatcttcg agggcctcaa ggcctaccgg
    10381 cacgccgacg gcggcgtccg gttgttccgg ccggagctga acgcgcgccg gttcgccgcc
    10441 tccgcgcgca ggctcgccct gcccgaactg cccgaggaag cgttcctgcg cagcgtcgag
    10501 cagctcgtgc gcgccgacga ggcctgggtt cccgacggct ccgacgagcg cagcctgtac
    10561 ctgcggccgt acatgttcgc cagcgaggcg ttcctcggtg tgcgcccggc ggctgagatc
    10621 cggtacgcgg tgatcgcgag cccggccggt gcctacttcc cggcgggcgt cgccggggtg
    10681 acgctgtgga tcagcaccgc gtacacgcgc gcggcggcgg gcggcaccgg cgcggccaag
    10741 tgcggcggca actacgccgg tgggctggcc gcccagctgg aggcgaagcg gcacggctgc
    10801 gaccaggtgc tctacctgga cagcgcgcac cgttcgaagc tcgaggaatc gggcacgatg
    10861 aacctgtgcc tggtcaccga ggaccgccgc ctggtcacgc ccggcctcgg caccatcctc
    10921 gaaggcgtga cgcgcgacag cgtgctcgcc ctcgcggagg aacacggcct gacgcccgtc
    10981 gaacggtccg tcgatctggc ggaactgcgc gcgggcgagt tcaccgaggt gttcgcgacc
    11041 ggcaccgcgg cggtgatcac cccgatcgtc ggcttccgcg acgaagaggg cgaaaccgtg
    11101 atcggcgacg gcgagccggg gaagaccacg ctcgccctgc gcgagcacct gctcgacctt
    11161 cagtacggcc gcatcgagga caccaggggc tggctccgcc gcgtgacctg acccgcctcc
    11221 ggtggcgcgg cgccgtccgc gccaccggaa ttttcgattc cgtcacgggt cgaaaaagga
    11281 ggggtaaagt tcatgaacat tctcttggct tttactttgc attggtgtcc ggcgccactg
    11341 gaaaagagca ctccgtgacc ggccccccgg gtctagaatc acggtatgta catagccttg
    11401 cagaaatacc tcgaaccgga gatcgaagtc gactactcac tcgccgaaca catgatctgg
    11461 ttacgaaagc agttcgaaag ggggattttc gtcgctgccg gaaaatgtac cacggattcc
    11521 gggagggtta ttctcgtccg cccgctcggc caggacaagc tccgcgccat cctggccacc
    11581 gacccgctcg tgctccggca cctggcgcgc tacgagctcg tcgagttctc accgaccagg
    11641 accgcggacg acctgctcgg catcaacgag gcgctcgcct cctgacctct tcgcacggac
    11701 accgacgagc ccggcgcgac ccccgcacca agacgagcgc gcacgccggg cccgccgtga
    11761 atcaccgctt cgacttgact ttgtcgcgca ccccggaaaa cagcctccgc ccgcctgcca
    11821 gcaccggcca cgccgcgatc gcgccgaacc cgatcggaat tccctgctgc cacgacggcg
    11881 cgctcaggcc agccgccacc gtcgtcgact gggccttctc ctgcggattg tgatcactga
    11941 ccccgcccca cctgctcggc ggcagcacga tgatccgcgc ctttccgatc acgttctcca
    12001 ccggcaccat gccgcccagc cgcttgtcgc cctggcatcg cgaatcgcac gaattgttcc
    12061 ggttgtcccc gagcacgaac aaggaattcg gcggcaccgt gatcggcggg aacgtgtcct
    12121 gctgctggtg cgacggggat tgccagtgca ggtacggctc gtcgagcgcc ttgccgtcca
    12181 ccaccacgcg gttcttcgcg tcgcagcact ggacggtctg gccagccgtc gcgatcacgc
    12241 gcttgacgaa gtcgcgctcg tccggcggcg cgagcccgaa cgccgaaccc acggtgtgca
    12301 ggaaccggac gaacgcgttg gacgacggct ccggcagcgc ctcgttcttc acccacggtt
    12361 cggggccctt gaacacgacc acctcgccgg gcgtcggctc ggtgaagtcg tagacgagct
    12421 tgtcgaccag gatcttgtcg ccgtagcagc cggtacagcc gtgcagcgtg ctctccatcg
    12481 agcccgacgg gatggtgtag accttcgcga agaactgctg gaacacgaac gccagtacga
    12541 gcgcgatcac gatcaggatc ggcagttcga cccagaacga gcgctgtttc ttcgccttgc
    12601 ggcgcctgcc cgagcgcggc gcggcctgct cgtcgggttc gggttcgttc tgggaagcgt
    12661 gctgggagag gggttcgacc acccggccag gctacgggaa tccggcacgg tgcctccggc
    12721 ccgacaccgg cccgtcgagt gaaagttcac cgagggccgc gggccggggc gggttcgtcc
    12781 ccgttcgccc ggtatcccct gcctcagccg gtcccggtgg cgggcagcgc gaacaacgcg
    12841 tactgcgcct cgtcgccccg gccgaggccg cgaatccggc ggcacttcag gcaggtgacc
    12901 tcgtgccgcg tcggcgtcag ctcgccggag ccgaggccgg accagccctg gtggcacgcg
    12961 ggcgccagca aggtcagccc gttgatccac gggcgatccg cggacgcgtg caccgcggag
    13021 gacagcccga tgcgcatgtt gtggccgcgg aaccggtcgt gctgcacctc ggcgaacacg
    13081 gccggatcca ccgtgggctc ggggaagagc gggatcggct cggacatgtg cccagtatgc
    13141 gccgcgcccc cgacagttcc ccggacctca ggtcagctcg tgccgccctc gggctcgtag
    13201 gcgaggttgg gccgcagcca gcgttcgacc tcggtgatgt cgaggccgcg gcgtttcgcg
    13261 tagtcctcga tctggtcgcg gccgagccgc ccgacggtga agtaccgcga accggggtgc
    13321 gcgaagatca ggccgctgac gctcgccgcc ggggtcatcg cgaacgaggt cgtcagctcc
    13381 atgccgatgg cccccgcgtc gagcaggtcg aacagttcct gtttgaggct gtggtccggg
    13441 ctcgccgggt agccgagcgc ggggcggatg ccgcggaagc gttcggcgtg caggtcctcg
    13501 agggccggtt cggcaccggg ctcgaaccat tcgcggcggg cgcgcaggtg caggtactcg
    13561 gcgaacgcct cggcgagccg gtcggccagc gccttgacca taatcgcctt gtagtcgtcg
    13621 tgctcggcct cgtagcgcgc ggcgagctct tcggcgccgt ggatggccac ggcgaacccg
    13681 ccgaggtgat cgccccgcgg cgccacgtag tcggcgaggc agcggttcgg cctccccgtc
    13741 ggcttttcgg tctgctgccg cagcatcggg aatcccacgc cgttctcgag caggatgtcg
    13801 tcgccgtcgg agtgcgcggg ccagaagccg taggcgccct ccgcgcggaa ctgccccttc
    13861 tcgatgatct cgtcgagcag ggcgttcccc tcgtcgaaca gctcgcgcgc caccggctgg
    13921 tccaggatcg ccgggtactt gcccttcagc tcccacgcca ggaagaagaa ctgccagtcg
    13981 atcatctcgc gcagttcggt gagcgcgggc cgcaccgtgc ggacgccggt gaactccggc
    14041 gtcggcagct cgtcgaacgg gacccgctca gggttcgcgc gagcctggtc gtaggtcagg
    14101 agcgcgcgct gctggcggtt cgcgtgctgc tcgcgcaggc gttcctgctc ggcccggttg
    14161 gcgacgtcga gaccgtccgc ccgctcgggg tcgagcaggt ccgaaacgac gcccaccacc
    14221 ctcgacgcgt cgagcacgtg cacggtggtc gcgtcgtagg cgggcgcgat ccgcaccgcg
    14281 gtgtgctggc gcgaggtggt cgcacctccg atcagcaggg gccgcttcag cccgcggcgc
    14341 tgcatttctc ctgccacgtt gaccatctcg tcgagcgacg gcgtgatcag cccggacagg
    14401 ccgatcacgt cggcgttctc ggcgaccgcg gtgtccagga tcttcgccgc gggcaccatc
    14461 accccgaggt cgatgacctc gtagttgttg cagcccagca cgacgccgac gatgttcttc
    14521 ccgatgtcgt gcacgtcgcc cttgaccgtg gcgagcacga ccttcccgtt gccgtgcccg
    14581 gaaaccaggg tgcccgccag ccgcgcctgc tccttctcct cctccatgaa cggttcgagg
    14641 taggcgaccg agcgcttcat cacccgcgcg ctcttgacca cctgcggcag gaacatcttc
    14701 ccggcgccga agaggtcccc gacgatcttc atcccgtcca tgagtggccc ctcgatcact
    14761 tcgagcggac gcgccagcga ctgccgcgct tcctccgtgt cgtcttcgat gaagtcgacg
    14821 atgccgtgca cgagcgcgtg cgacagccgc tccgccaccg gtgcgtcgcg ccaggacagg
    14881 tccacctcgc ggcgggttcc cttgccactg accgtttcgg cgaaggtgac cagccggtcg
    14941 gtggcgtcgg gccgccggtc gaacagcacg tcctcgacga gttccagcag gtctgcgggg
    15001 atgtcctggt agacggcgag ctgcccggcg ttgacgatgc ccatgtccag cccggccttg
    15061 accgcgtgga acaggaacgc cgagtgcatc gcctcgcgca ccacgttgtt gccgcggaag
    15121 gagaacgaca ggttcgagat cccgccgctg gtgtgcgcgc cgggacaacg ctgcttgatc
    15181 cggggcagcg cgtcgaggaa cgccttcgcg tagccgttgt gctccgagat gccggtggcg
    15241 accgcgagca cgttcgggtc gaacacgatg tcctcggcgg ggaaacccgc ttcactggtg
    15301 agcaggtcgt aggcgcgggc gcagatctcc accttgcggt cggcggtgtc ggcctgcccc
    15361 tgctcgtcga aggccatcac cacgacgccg gcgccgtagt cgcggatccg ccgcgcctgc
    15421 tcgaggaagg gcccctcccc ttccttcagg ctgatcgagt tgacgatccc cttgccctgc
    15481 acgcacttga ggcccgcttc gagcaccgtc cacttggaac tgtcgatcat gatcgggatc
    15541 ctggccacct cgggctcggt cgcgatcagg ttcaggaacg tggtcatcgc ccgctcgctg
    15601 tcgagcaggt cggcgtccat gttgacgtcg agcacgttcg cgccgccgcg gacctgctcc
    15661 agcgcgacgt cgacggcggc ctggtggtcg tcggcttcga tcagcctgcg gaaccgggcg
    15721 gaaccggtga cgttggtgcg ctccccgatc atcgcgaacc cggtgtcctc ggtcatctcc
    15781 cacggctcga gcccgctgaa ccgcgtgcgc gccgccggtg ccggtaccgg gcgggtcgcg
    15841 gcgccggaca ccgccgaggc gatcgcggag atgtgctccg gggtggtccc gcagcagccg
    15901 ccgacgatgt tcgccatccc ggacgcggcg aagtcgccga gcagctgccc catttcgccg
    15961 ggggtctggt cgtagccgcc gaaggcgttc ggcaggcccg cgttggggta gcacgcggtg
    16021 taggtggtcg cgagccggga cagctccgcg acgtgcggcc gcatctcctc ggcgccgagc
    16081 gagcagttca ggccgaccac cagcggggaa gcgtgctcga tggagcgcca gaacgcctcg
    16141 acggtctgcc cggacagtgt gcgcccgctc aggtcgacga tcgtcaccga gatccacagc
    16201 ggcaggtgcg gcgcgacctc gcgggcggcc gagatcgccg ccttcgcgtt gagcgtgtcg
    16261 aagatcgtct cgacgagcag cacgtcgaca ccgccctcgg cgagcgcctc gatctgctcc
    16321 gcgtaggcgg cgtggacctg gtcgaaggac accgcgcggt aagccgggtc ctcgacccgc
    16381 ggcgacagcg aaagggtcac gttgagcggc ccgatggacc ccgccacgaa ccgcccgccc
    16441 gcctcgtccg cggcctgccg cgcgagttcg gcggcgcgca ggttcatctc cctgaccagg
    16501 gactccagcc cgtagtcggc ctggccgacg ctggtggcgg tgaaggtgtt ggtggtggtg
    16561 acgtccgcgc ccgcggcgag gtactggcgg tgcacgtcga ggatcacgtc ggggcgcgtg
    16621 aggttcagca ggtcggggtc gccggtgacg tccttggggt gctcgccgaa ccggtcgccg
    16681 cggtagtccg ccggggtgag cccggcgttc tggagcatgg tgccccaccc gccgtcgagg
    16741 accacaaccc gctggtccag aagctcccgc agggccttct cgccgctcgc cgtgccggcc
    16801 acagccacct cccaagtagt gggaggcgcc cttgcggaag ttcagcgagc cgagcgtggc
    16861 gggccggaac ccgttgcagc gcctctcgac tcgacgacca ggatagtggg tgacccggcc
    16921 ccgacgccag gttcccacct ggtgcgaacc gcgacggtgc ccggcccggc cgccccgccg
    16981 gctcgctccc ctgactccag ccacaacgga ctgtccattc cggacactgg cggccgcgtc
    17041 ccgctgtcgt cgtggcaggc ctcaggatcg agcttcggca gggctctggt ggctcccgcc
    17101 gtcgacggga tcgttgaaat accggtccgg gtgccgcgcg agcaccgccg gtcccggcgc
    17161 gctcggcccg tagtcctgct ccgccgccgt ttctcgccgg aaatacgcgt cgaacgcgcg
    17221 gccgtcgcac tcgtccgagg gctgcgcgcg cacccggtac cccgccgcct cggccgccct
    17281 cgccaggttc tcggggtcga ccccgtcgtg ctcggcgcgc ggatggccgg tcagcgcggc
    17341 cagcgcggcg agatcgggcg ccagcctggc gttggggatc ccggtcaccc agaactcggc
    17401 gggcaccgcg gtgccctgcc accacggcag accgtccaca tcggaattgc cggggcgcca
    17461 ccggacgacg gggacctcgg cggtcttcgc cgtgtccttc ttggacagca cgacgtcata
    17521 ccggtagcgc gtgagctcgt tgtgggccgt acctcgtttc agcatgagtg cggccgagcg
    17581 gaacgcgtgc ccagcggtcg cgtatgaggt gaagaacgac ggatcgatga gtagctcccg
    17641 ctccaggtcg aggttccgcc ggaacagggc ggcgtgtgtg gggcccccgg gtcccgtggc
    17701 ggaccgggcc gcagccacac ccgcgtggaa gcagtcgagc agccgcaggt tccgcacgtc
    17761 cccgacgaac agctcgccgt cgggccggag cgcggcggcg cagccgtcga acacgtcctc
    17821 gcagtacccg ccggagggga agtactgcac gaccgagttg accaccacga cgtcgaagga
    17881 accggcgggg acgccggtga aatcggtggc agcgcggttg agcagggtga ccttggccgc
    17941 catccgcggc accgcggcga gctggctggc gagccggtcg agagcgggcg cggagaagtc
    18001 ggtggcccag tacgactcgc agtgcggtgc caggtgggcc aggagcagtc cgctgccgac
    18061 cccgatttcg aggatccgac gcggccgcag cgcgcggatc ctggccaccg tcgtcgcgcg
    18121 ccattcgcgc atgtccgcca gcgggatcgg cgccccgtcg taactgctgg tccagatcga
    18181 gaagtcttca ccgaggtcgg atccgccgcc ggcggcgtag tggtcgtcgt ggatcgcccg
    18241 ccactcggcg agccgctgcc cggccgcgtc cggtaacgag ccgggggcgc ccaccccgtc
    18301 cgccgcgtcc gtcacggcgg gcagcagggt cgcgatgcgg gccaccgtcc ggcgttcgaa
    18361 caggtccgcc atggtcatgc ccacgccgtg gctcgcacgg acccggctga ccaactgggc
    18421 acccaggagg gaatgcccgc cgcgatcgaa gaagtcgtcg tcgatgccga cctcgccgac
    18481 gccgagcagc tcgctgaacg cccggcagag cgcttcctcc tggctggtgc gcggtgcgcg
    18541 gcgggcgacg tctgcggccc acaccggttc ggggagtgcg ctccggtcga gcttcccgtt
    18601 gtccgtcaac gggaagcggg gtacttcgac gaaaaccgac gggaccatat ggccgggcag
    18661 tgtcctggcg cagtgcttca ccagcgagcg ggccgggggc aggtcgcacc cgggacgcgg
    18721 ccgcaggtac gcgacgagcc gcctgtcggc cgctgagatc tccttcgcga cgaccaccgc
    18781 ccgttccacc tcgggcagct cggcgagtac ggactcgatc tcgcccggtt ctatccggaa
    18841 gccccggatc ttcacctggt ggtcggcccg gccgaggaag accagtgtcc gctcccgccg
    18901 gacgaggtcg ccggtgcggt acaggcgcga gcccggcggc ccgaacggat cggccacgaa
    18961 ccgggtcgcg gtgagccctg gccggtggag gtagccgcgc gccagcccgt cacccgcgat
    19021 gtacagctcg ccctccggca ccgagcgcaa cgcctcgtcc agcacgtaca gccgggtgtt
    19081 gcggatcgcc tcaccgagcg acgccgacgg ggcgtcgtcg cggacccggt gccgggagga
    19141 ccagatcgtg gtctcggtcg gcccgtacag gttcaccacg cgggccgagg ccgccgtcat
    19201 cgcggacgcc agtcccggcg gcagcgcctc cccgccgacc agcgcggtca cgttccggaa
    19261 cgacgggccg gtcaggacca tctgccacag tgcgggcgtc gcctgcatga tcgtgatccg
    19321 gtcgtcggcc accgtccggc ggagcgcgtc cggatcgcgc gcctcctcgt cgccggccag
    19381 cacgaccgcc gccccggaga tcagcggcag gtagagctcc agaccggcga tgtcgaacgc
    19441 gatggtggtg acggccagca gccggtcctc ggcggtcagc gggaattcgc ggcgcatcgc
    19501 cagcaggaag ttcgtcaggc cggcgcgggt gaccacgacg cccttgggcg tgccggtgga
    19561 accggaggtg tagatcacgt acgcggcgct cgccgggtgg ggatcggccg tgcggagcgc
    19621 cgcggggcgc ccggtcaggt ccagctcgtc gaggacgagc tccgccgggt acctgccgcg
    19681 gagcacggcc gtggtgagca cgacctgcgg tccggcgtcg ccgaggatga acgagacgcg
    19741 gtcgcgcggg taggacggat cgatcggcag gtacgcggca ccggtcttga ggaccgccaa
    19801 cagcgcgacg accagatcgg ccgaccgggg caggacgagc ccgacgatcg agcccgcccc
    19861 cactccgcgg tcgaccaggt gcccggccag gcggaccgcc cgcgcgtcca gctccgcgta
    19921 ggtgaggtgc tccccgcgga actccacggc gaccgcctcc ggcgtccgcg cgacctgttc
    19981 ctcgaacagc gcgcacgggg tcacgaccgc acgcgccgga gctcggcctc gatcacgtcg
    20041 gcgatcagcg gcaggtggtc ggcgtcgagc agatcgaagt ggctgacccc catcgggtgg
    20101 ctgcggacct cgccggagat gaagtcccgc cacgaatgcg gattgagccg ccactcgtct
    20161 ggatggccga cggcctggaa gtggacgatg tcgccgcggt gcgtcccggg ctcgtggtgg
    20221 ctggccagcc actggtgccg ggtgaggatg cccgcgagca gcgccagccg ttcctcctcg
    20281 atggtctccc ccgcgtccat ctgcgggaag cactgccgca ccagcgcgat gtgcagcggg
    20341 ttgacctcgg cgatgtccgg gctcgcgatg cccggcggcg tgccggcgta ggggtaggag
    20401 tccagcaccg cgagcagctc cacctcctcg ccctcgtcgc tgagcatggt ggacatcgcg
    20461 tgcgcgatgt tgccgccgaa cgaccagccg acgaaccggt acggcccgtg cggctgcagg
    20521 ctccgcacgt gctcgaggta gtcggtcgcc atcgccggga tgtccagcac catgtggtcg
    20581 agcccgtgca ccgccctgga ctggatcgtg tagagcggat tgccgcgcag gtgccgtccg
    20641 aacccgaagt agcaccagcc aaggccgatt cccgggtgca ggaagaagat cggcctgccg
    20701 tcgccgccgg tgcggatcgg catcagcagg tccatggcgt caccggtgcc gccgtggccg
    20761 atcagggcgc ccagctcggt cacggtcggt gcctggaaga tcgcgcccac gccgagttcg
    20821 acgccgagcg attccttgat cagccccacc agcttcgccg ctaccagcga gtgcccgccg
    20881 agctcgaaga agttgccgtc cacgccgacg ctttcgatgt cgagcgcccg tgcgaacagc
    20941 tcggccaacc gggcctcctg cggcgtgctc ggcgccttgc cggcgacggt cacccgcttg
    21001 ggcgccggga gggccgcgcg gtcgagcttc ccgttggccg acagcgggat ccggtcgagg
    21061 tacacgaagt ccgtcggcag catcgcggga gtcagcaagt tccccgcgat ggcccgcagg
    21121 tccgccgaga accggtccgg gtcgaaccag cgctcgtccg ccgcggcggc gaccggcgcg
    21181 gcgctgcccg gccggaccgc gaacacgttc accagcccgc tgtcgacgag caggtccgcg
    21241 gtctccgacg cggtcgtgaa accgtgaccc acgagcaagt cgaccacggc ggccagccga
    21301 tcaccggtgt cgtgcacctc cacgacgacc tgatcgatcc gcgcccagtg ctcgtcccgg
    21361 acgcccgcga gcacttcgag ctcgctgttc tccgcgtcca ccttcagcag gtcgacgtgc
    21421 gcgatggcgt gctcgtcgag cacggacgac agggtacgca gctcgcacgt gacctcttgg
    21481 cgctccttga gccgttggga gatcaggacc tccagctcac cactgagagc ggcgaagtcg
    21541 ccaggcccct gcgcgaggcg cttgatccgg ctgcccgcca gcgcgcccgc ctccgccagg
    21601 tcgccgaact gaccggacag catggagaac tgcgggtagt acacgaaatc ggccgtgcca
    21661 ggccggtccg aaaggccgta cgggaacgcg tgcgtgtgga tgtcgttcag gctcgtgttg
    21721 agcaccatct cccggtacag ctcgggaatc ggctcgaacg cgtagatcgt gacgtttctg
    21781 gcctgggtgc cgacgaacag gctgaacatg ccgacgtgcg caccgacgtc caggacggtc
    21841 gcgccgtccg gcacgctgat gccgtgccgc aggtattcct tgcgctcgaa gatctcctgg
    21901 tagaggtact cgatctcggc ggcgttgcgg ccgaggacca gccgtccgtt cggcagcggg
    21961 tgccggggca ggtcgtcgat ctcgccggtc tcctcccacc gggcgatggc gcgcaccccc
    22021 ggtgccgctc cggcgttcgg cacgacgtag gcgaccagac gctggacgtc cggctcgggt
    22081 gcgtggaccg ccaccgccac ctggtcggcg gcggggtgcg cggcgaccgc ggcgctgatc
    22141 tcatcgggct cgatccggac accgcgcagc ttcacctggt ggtcaccgcg gccgaggtac
    22201 tggagctggc ccgccggggt ccagcgcacg aggtcgccgg tccggtacat ccgggtgccc
    22261 ggcgggccgc ccgggtcggc gacgaaccgt tccgccgtca gcctcgggtt gtgccggtag
    22321 ccgcgggcga gctggacgcc tgccaggtac agctcaccgg ggaccccgat ggcgaccgcg
    22381 tccaggttcg cgtccagcac gcgcgcccgg gtgttccaca ccggcgcgcc gatcgggacc
    22441 gaggtggcgt cggtgtccgg gaggcatcgc cagctcgtga cgtccacagc ggcctcggtc
    22501 ggcccgtaga ggttggccag gggcgcgtcc atgacctggt ggtactggtg ctgcagcgcc
    22561 ggggaaagcg cctcgccgct gcagatcacg cggcgcagat cgaacgtgcc ggggtcggcg
    22621 ccgagttcgg tgaggaacgc ctggagcatc gacggcacga agtggatcgt ggtgatccgt
    22681 tcggcgcgca ggacaccggc caggtaacgc gggtcccggt gcccgcccgg cgcggccacg
    22741 accagggtgg cgccctcgac gaaggcccag aagaactccc acaccgacac gtcgaagccc
    22801 gccggggtct tctggagcac ccggtcgtcg ggccgcagcc cgaattccgc ctgcatccac
    22861 agcagccggt tgacgatggc ctcgtgctcg atgaccaccc ccttcggcct gccggtcgac
    22921 ccggaggtga acagcacgta ggcgggagtg cgcgggtgct gccccggcgg ggtgtacggg
    22981 ccagcgggca gctcggacag ctcccggtag gtctcctcgt cgaggacgaa caccggttcc
    23041 gcgtcggtga tcatcgcgtc gcggcggccc gcgggcaggt cgggctcgat cggcaggtac
    23101 gcggcgcccg accggacgac cgcgaccagc gcgacgatca gctcgatcga gcggggcagc
    23161 gccacggcca ccacccgctc gaccccggca cccctggatc gcagtgccat cgccagccgg
    23221 ccggatctgc ggtccagttc cgcgtaggtt agccgctcgt cttcgaacac cagcgcctcg
    23281 gcgtccgggt cggccgtcat ccgccggtcc agcagttcgg tcagggtcac cggcgggatt
    23341 tcggcgccgg tggcgttcca ccgcgccatc agctcgcgtt cggcgtcccc aagcacgtcg
    23401 accgcggtga tcgactggcc ggggtcggcg gtgacctggg tcaagacccg gaccagccgg
    23461 tcgagcagcc gctcgacggt gtcccggtcg tacaggtccg tggcgtagtc cagcacgcag
    23521 tccacgccct ggccgtccgg ccgttcggtg aacgcgaagt gcaggtcgaa cttggcgacc
    23581 ttgacgttga cctgccgccg ccgcacggtc aggccggtca ggtcgacgcg gccctcgtcg
    23641 aagccctgga agaccagcat gacctggaac agggggtgac ggccgagcgt gcgcgccggg
    23701 gcggcgatct ccaccacctg ctcgaagtcc aagtcctggt ggtcctgcgc ggccaggttg
    23761 acgtcgcgga ccctggcgag cagctcggcg aagctcgggt cgccgccgag gtcgtagcgc
    23821 agcacgatgg tgttgacgaa gaagccgacg agatcggcga gggcctcttc ggtccggccc
    23881 gccaccacgc cgccgatcgg gatgtcggtg ccgcagccga gtttcgccag cagcaccgcg
    23941 agtcccgcgt tgagcaccat gttgaggctg acgtggtggc tggtggccac gtcacggagg
    24001 cgcccgtgca gctcgggacc gagctccagc gcgatccgcg cgccgaccat gctggcttgc
    24061 gccgaacggg accggtcggc catcggcgat acctcggccg gcagtccggc gagctgctcg
    24121 cgccagtact cgccctgctt ggcggccagc ttgcggccgt cccggatgtc gccgagcgtc
    24181 gccagctgcc agcggctgta gtcgccgtac cgcaccggca gcggcgtcca ctgtggactg
    24241 tggccttcga cgcgggcctg gtacgcgtgg ccgaggtccc tgccgaacgg cgccagcgac
    24301 acgccgtcgc ccgcgatgtg gtggatgagc accagcaggg tgtggtcgtc ccggccggtc
    24361 ttccacagcc agaccctgat cgggatctcg gcgatcaggt cgaacgggta ctgcgccgcc
    24421 tcgtccagtg cgtcctggac ctcgtcctcg gcgatctcgg cgtaccggag ctcgagcctg
    24481 gttcccagca cttcctggta ggggttgccg tcggcggacg ggaacacggt cctcagcgcg
    24541 tcgtgccggg tgatcacgtc ctggaacgcc tcggccagcg cggcccggtc cagcggccct
    24601 gtcagccgca tcgcgagcgg catgttgtaa gtgggatcgg cgccctgggt ctggaagtgg
    24661 aaccagagcc tgcgctgcgg gaacgacagc ggggtcgggt cgagcgacgg tcgcggggcc
    24721 agcggctggc gggtgcccgc ggcctggtcg atcgtggtgg ccagccgcgc gaccgtcggg
    24781 ttgtcgaaca ccgcgcggat gctcagctcc gcgcccagtt cggcgcgcac ccggctcacc
    24841 agctgggcca ccaggaagga atggccaccc agttcgaaga actcgtcgtc gatgctcacc
    24901 tcgggcagct tcaggacgtc cgcgaacagc gcgcacagca cttcctcgcg cgtggtgcgg
    24961 ggccgccgtc ccatcccggc cagcggtttg ccggggaacg gcagatcggc gcgccggact
    25021 cgcccgtgcg cgtccagcgg ccaggtgtcc agcgcgacga acgcggcggg caccaggtac
    25081 tccggcagcc ggtcggcggt gaaccggccg accgcggcgg tatcgcgcgt cccgctgatg
    25141 aagcagatca gcctgcgctc gccgttcggg tcgtcgtgcg cgacggccgc gaccctggtg
    25201 acgtcggggt gctcgccgac cacgcgttcg atctcggcgg tgtccgcccg gaacccgtcg
    25261 aggctgatcc actcctcgag ccggccgagc acccgcgcgg tcccgtccgg ctcccgcacg
    25321 gcgaggttgc cggtcggcga tccggacaca tacagctcac cgggtatgcc ttcggggagc
    25381 cgggtcatgc cgaggcccac gacctcgcgt tccgacggcg cgccgccgta gaggtccgcg
    25441 ccgagcaggc tgccgtcctg gtcgcccacc acgagttcga ccaggcgccg gacgagctgc
    25501 cccaagcggt cggccgtgtc ctggcgaaac agctcaggcc ggtagatgaa cgtcccggtg
    25561 aggcggtcgt ccacgatctc gacgcggaac tcgatgtcga accgggtcag cacgtccagc
    25621 cagggcagac gctccggcgt ccgggtgccc tcggctcggg gggcgtgttc gccctggtag
    25681 atgtacagca cctcgaacag ggggttgcgg ccggttcgcc gtccggggcg cagctcggcc
    25741 acgacctggt cgaacggcac gtcctggtgc gtgtacgcgc gcgtcatggt cgcgtgggcc
    25801 gtgcgcagga actcgcggaa gcccatggac ggcgaaacct tggtacgcaa cgtgacggtg
    25861 ttgacgaaca ggccgatgac gtcgtcgaac tccgtccgct gccgcccgtt gagcacggcg
    25921 ccgatcacga cgtcgtcctg gccgctgtgc accgccagcg cggcctggaa gatccccgcc
    25981 atcgcactgg aaaccgtgca gcgccaccgc agcgcgatcg ctttgaacgc cgcggtcaga
    26041 tccgcggtca gcgtgaactc gctcgtcgcg cccgccgcgg tgaacttcgc cggtctcggg
    26101 aagtccagcg gcagatccag ggtgcgggcg tcggcgagct cgtcccgcca gtacgcgagc
    26161 ctcgactcga catccgtgtt ctcccgctgc cagcacacgt agtccgcgta ggacgccgcg
    26221 gggccgggca gccgcggcgc ctcgccgcgc agctccgctt cgtacactgt ggacagttca
    26281 tcggtgagca cggcgaacga ccggccgtcc atcacgatgt ggtggaacac caggcacagc
    26341 acggcggacc cgtccggcag ggtgacgagc atgcccttgg ccggcggcgc cgcggacagg
    26401 tcgaagggga ccgccacgaa cgggtccgcg accgagcgcc agtcgccgtc ggtggtttcc
    26461 cgggtgatcg ggatggaaaa gccgtcggct tcggcgacgt acggactgcc ctcgtcgtcg
    26521 gccaggaaca ccgacctgag caccgcgtgc cgcgccacca ggtagtccag accgcgccgc
    26581 agcgcccggt cgtccacgcc gccagcgaac cgtagcgcga tcctggcgtt gtaggcactg
    26641 ctggccgagc tcatctgctg gagcagccac atccgctcct ggccggacga aagtcgggtc
    26701 atctcggtcg ctctccctag ctctcctgca cgtccatcgg gcgctcagcg ggctgttccg
    26761 cctcccctgc cggttgctcc tcggctcgca cctcgtcgcc acgtgcccgc agcgccgcca
    26821 cgaacaggac gaccagcagc gccagtgcga tgatcagcac cggcacgttc gtgccctgcc
    26881 agccgaggaa gtagaagacc gtgctcgcgg acagcgacgc ggcgacgccg gtcaccgacc
    26941 cgatgccttc cgcgacggcc tggatcctgc cgccgcgccc gcgcgggtag caccggacga
    27001 gcagggtggt cccggccagg tagaggaagt tccagccgac gccgttgagc gtcagcgcga
    27061 tcaggaagtt cacgaacccg tcgccgccga gcccggcgat cgccgcgacc acgaacagcg
    27121 cggcgccgat cacggaggtc cgggccgggc cgatccgcgc cacgatgttg ccgctgaaca
    27181 cggcgggcgc gaacatgccg acgaggtgcc actggatgat cgtggcgccc atgctcgacg
    27241 agtggcccgc gtgctggctg ccgagcgggc cgacggccat gatcatcgtc atcatcgcac
    27301 cggagccggc gagggccagc agcccggtga tgaactgcct ggtgcccctg acctcggcca
    27361 gcgggaccgg gaccggcttc tcgccgtcgg tcttggcacg cacgccgctc gcccggatcg
    27421 ccagcagcag cggaatgttc agcatcgcgt acacgccgac catgaagtac gaacccgcgt
    27481 actgggcgcc gaagaacgcc gagctggtgg tcgccacgaa cggtccgatg aacgcggcca
    27541 gcagcccgcc gtagagcacg aacgacagaa cccgttcgcg ttggcccgaa ggagcgcgat
    27601 ccgcggccat gtaccggatg tagccgccgg tggagcggta ggcaccgacg agcgcggtac
    27661 cgcagcacag cagcgggaag tcgtgggtgg acaccgcgat caccgacagc gccgcaccga
    27721 ccatggccgc gatcgcgccg gtgatcatga cgcgcacgta gccgatgctg gcggtgagga
    27781 agcccgcgat gaacgagcac accgtgccgg cgatggtgat cgtcgccagc ggcagagtcg
    27841 ccagcgcggg ggtcggtgcc aaggcgaggc ccacgacgcc ggtgagcgtc aggtcgatgc
    27901 tgatgcccat gaagtagaac gtctggcacg ccacgagcag ccaactgctc cggccgatgc
    27961 cgacgccgac gtaccggcgc caccccgtcg ggatacccgt catcggcttg ccatcctcgc
    28021 ggcccggcca ctggcgttcg aggcgacgaa ctccgcccgg tggccggcga cccagcgctg
    28081 ggacgccgcc acgccgtcga ccgcgccctt cagccgcggc acgacctcgc gggcgaacag
    28141 ccggaggctg cgctcccgcg cctcctcggg ggcccagtcc tgcaacgaga gcagcaggca
    28201 gccgaatccg gacacccgct cggccagcgc ggtgatcgcc cgcacgcagt ccgacggcga
    28261 gccggcgatg atcccgccct gctcgatcgt gtagtcgaaa gccttctgct gagccacgtc
    28321 cgcggtcggg atcggcaccc cgagggtgtc cttgtacaga tcggaccgct ggaaccgcca
    28381 gccgtcgaac agctcggcct tggcctggtc gaccgagtcg ctcacgtgca ccggcaccac
    28441 caggcgccac tcccgccggt ccaccggccg tcccgcctcg ttctccaggt gctcccactg
    28501 gccgggcagc cgatcgacgc cgatgtcctg gcccgcgcgg atcgcgcccc acggcggtgc
    28561 cacgtgggac atcgcgctga tgccgagccg accggcgagc cgcatgctga acggggtcgc
    28621 cgcgctggcc acgacgagct cgatcgggcc ggccaccgga cgcgtctgaa ccctcgcgtc
    28681 gtccatcctg aaccagtcgg tctccgccga gaccacctcg cccgccagca gccgctgaat
    28741 cacttcgagc gcctgcgcga gccggtcgcg cgtggtggcc gggtcgatcc ccagcatgtg
    28801 catgtcggcc tggtacgcgc cggatcccgc gccgaggacg aaccttccgt cggtcaaatg
    28861 gttcagcagg acagcgcgct cggcgaccag gaacgggtgg tggtacggca gcccgagcac
    28921 gccggtggcg aaccggatcc gccgggttcg ctgtgccgcc gccgcgatga acagctccgg
    28981 gctgctcagc gtcgcccagc cgccggagtg gtgctcgccg acccagaact cgtcgaaccc
    29041 gagctcgtcc agggtttcgg ccaggcgcag gtcctctttg agcagcaggg cgggatcggt
    29101 ccccggacgg tgcagaggag aggtgaagca gccgaaacgg gtgggcaact gcatagtgtc
    29161 tcctgacagg atcacagccg ggacgcgatc gcggcacgct ggatctggtt ggttccctcg
    29221 atgatttgga acagcttcgc ctcgcgcatc caccgctcca ccggctcggc cccggtgtac
    29281 ccgcgggcgc ccagtacctg gaccgcgttc gccgtgacct tcatcgccgt gtccgtcgcg
    29341 agcactttcg cttgcgcggc aagcagttcg ctccggccgc cgcccacatc gacctcgcgg
    29401 cacgcgtggt gcagcaactg ccgggacgcc tcgatctcga tcgaggcgtc cgccagcagg
    29461 aacccgacgc cctggaaggt gatgaccggc gcgccgaact gctcccgggt cctggcgtgc
    29521 gtgacggcac gggtcagcgc ggcttcggcg agcccgatcg cgcaggcggc gatccccagc
    29581 ctgccctgga cgaaaaaact ctgcgcggcc accatgccgc ggttgacccg gcccaccacg
    29641 cgcccggcgg gcaccctgac gtcgtggaac gcgatctgcg cggtcggcag cgcccgcact
    29701 cccatcttgt cctcggcccg ccgcacttcg acacccggtg acgcggtgtc gaccaggaag
    29761 caggtgatgc cgccgagacc accaccgccg gttcgggcgt agacgttgag cagccccgct
    29821 accccagcgt gcccgaccca tgccttcacc ccgttgagcc ggtagccgtc gccatccggt
    29881 tcggcggtgg tcgcgatcag cgccagatcc gatcccgccc ccggctcgga caggcagttg
    29941 cccgcgatca cccgcccctg ccgcagccgc gcgaggaact cctcgcgcag ttccggggag
    30001 ccgtgcctgg ccagcgcgca ggtcgccagc gcctgcaggt gcaccgattc ggcgggcgcg
    30061 acccaggcgg tggccacgcg ctccaccgct cggcagaaca gttcggtccg atgtggacgt
    30121 tcggtgacca aagcgggcag gcccagctcg cacagccgtc gcacgagttc gagggggtag
    30181 gtctcgcccc gctcgtgctc ggcggcgagt tcgggggtga tcccggcggc cacgatctcg
    30241 tcgacccggc cgagcagctc gtcaggttcc atcgccgtac atccgcgagt agacgtcgaa
    30301 gaccgggtac agaccaggcg ccagaccacg ggcataccgg gcgacgtcga ccagcccggt
    30361 ggccgccgcg cgcagatcgc ttacggaatg cgtgatggac aacgacattc ccggcagatc
    30421 gaaggtgacg gcgtgatcgc tgaccggctg gccgctgcgc tgggcggtgg tgccgccgca
    30481 caactcgggc ggggcggccg acgcccacgc cgcggccagc gacttcgcgg acgcgctcgg
    30541 actgtccttt ttggtcaccg gatggcgttc gtgcaccgac atcctcggcc gtttccccgc
    30601 cgaggcgacc atggtggcga tggtgcgcac cagccgggtc tgcatccagt ggccgaccga
    30661 caggttgtcg gccagtacga cgacctggtc gcggccgagt tcggccagcg accgccgtgc
    30721 gtcatcggac accgtggaca cgcagtacac cagcgcggcg ccggcgttcc ggcagtgctc
    30781 gacggtgtcc ggaagcgcat cggggacgct cgtgtcggcg agcacggaca cgcgcgcgga
    30841 ctcgcgccag cccgcccgtg acgcggtgag cccgatgtgg acgccctgcc gctcgcactc
    30901 ggcgcggact gccgtgccga agcggccggt cgcaccgacg acaccgagca cgaactcagg
    30961 caacgttctg ctcccgcagg aacccgacga tggtactgac cctgccgagg aactgcgtgt
    31021 ccgcttcgac gtcgatgtac accccgtagg tggtctccag cgagtcgatg agctggagga
    31081 acgacaacga ggagaagccc ttctccagca ggttcgccga ttcgtcccac acctgctcgc
    31141 cggtcaccac cccaccggac gactccacga tcaagtccgc gacctggtcg gacagctccg
    31201 aatccgtgta cgtcacacct gtcccctagt cgtcggttcg ttgtgccagc agtcgcgcca
    31261 cctcggcgcg ttgcgtcttc ccggcgccgt tccgcgggat ctccggtacc tggacgatcc
    31321 gttcgggcac tttgaacggc gcggcccggt cgaggcagta ccggcgtagc gccaccacgt
    31381 cgatcgcacc gcgcgccacg acgatcgcgc cgaggtacgg ccgtccggtt cccgcggcga
    31441 ccatggtggc ggagcacgcg tcgatctccg ggtgtcctcc gagcaggtct tcgacctcgg
    31501 ccgcggtgaa cttcttgccg ccgacactga acgagtcgtc cacccgctcg cccagcacga
    31561 gttcaccgcg gccggtcagg ctgccctggt cgctggaccg atagtggccc gattcggtga
    31621 tccggtcctc cagcgcgccc gggtagttga ggtaccggct gcccatggaa gggctcttcg
    31681 ccagcagcgt gccgttctcg aaccggagcg acacgcccgg aagcgggtag ccctgaccgc
    31741 cgccgggcac cgggtcgggg ttgaaggtga gcggcccggt ttcggcgatc ccgtagtagt
    31801 cggcgatccg gatgccgtgc cgtgcgagcg cagcgctcgt gtccggcgcc aggcgcgccg
    31861 cggatgacag cgccagccgc ggccggtgac cgcggattcc ggcaccaccc gaaccggcca
    31921 gcgagtcgta ggcggcgggg aacgcgacga gcaccgtcgg gtccacggcc gtgaggtggc
    31981 gcctgatgtt gcccgcggtc ggcagcccgg cgggcaggtg gatgctcgcg ccggcgagga
    32041 gtccggggat cagcgcggcg ttgaacccga gtccgttgta cagtccggcg aagcacagta
    32101 tccggtcctc ttcggacatt ccgctggcca cgcgccagcc ctcggccgcg ccgaggacgg
    32161 ccgcgccgga gaactcgatg caccccggcg tcctggtgga accggacgtg aggcggcaca
    32221 gttcggtgtc cggcagcaga tccggccgcg caccggcccg gccagtcgga ctcagccggg
    32281 ttccggcgtg cgctaccgtc ccgccgaccg gtggcagctt gggcacctcg tcgtgcagca
    32341 ccgcgtcgat accgcagtcc gcgaagagct tggccagttc actcgtcccc agcgaagggt
    32401 ccatcaggaa cgggacgtgg ccaccgccga gcaccgcgag cagatcggac acgtaccccg
    32461 gcgaattccg ccggatgacc gccacccgcg cggcgggcgc cacgacctcg tcgagcctcg
    32521 cccgcttcgc gtccgcgcgg gtgagcaggt cgggaccgtg gacgcgctcc gcgagcgagc
    32581 cgaccacggc ctcctggtgg gcggcgaggc ttgtcgccag cgcgtggaag agtttcccgg
    32641 tcatcggctg tggttcccgc ccgtgctggc cacgtcccat ttttcgctgg cggtctcgta
    32701 accgaacgcc aggaggaaca gcacttcgtc agtggtgccg cagagctcgg cccaccgtcc
    32761 cggatcgaat ccgccgacac ccgtgacggc caaaccctcg cgtgccgcga ccaggtagcc
    32821 cagttccccc gcgatgcccg cgccgatgag cgtgcgttgc gccgcttcgg acaacgcggc
    32881 cgggccggtg tcagcgatcg cgccgtggat cgccaggaac gtgctcgcct cgaccaggtt
    32941 ctgctggccg agcagcgcct cggccagcca ggcccggtcc ggcggttcgg ctccaactcc
    33001 cggatgccgc gagaacaccg tgatgcctgg cacgggcacg tcgaacgccg gaatgtggcg
    33061 ctcgcagagc cgctggatct cggcgacggc gccggtcaga ccgtcctgat ccgccttcgt
    33121 gccgagcgcg atggccgatc tgcgcgcgcc gagcccgggg gccagcgatc cggcgcccgg
    33181 cagcgcgggc acctggacgg gggccggtgg cggcgggacc agctcggcga tcatgcactc
    33241 cagatcggtc accggaatgt ccactatgga ctgttcatgg accacccagc ccggttgggc
    33301 agacctcggt gtgtcggcga ggacggtgcc gaagccgagc agcacccccg tgtgaccgag
    33361 tgcgtattcc cgcgcggcgg caagggaatc cggccacgag gcccggtcgc ggccgacgga
    33421 gagcgcgagg ttgagcagtg cgtggccgac gtcgagcagg tggtagaggt aaccgcgtct
    33481 gccgtaacgg cgcatcgaca gccacggcct gccgacgagg aagtaggtgt aggcgtcccc
    33541 ggtccagcgg tgccgctcgg cgccgtcgat gacgatcctg cgccgcgcca ggtcgaccac
    33601 gccgatcacc ggctccccgg cgggcgccag caggatctcg tacgggtagc acgcgcccgc
    33661 ggacggcgcg gcgcgtttgc ccgatcccgg ccgggcaccg accgcgaact cgatctgtgc
    33721 gatcacgcgc tccagcgctt cgggcacggc ggagaagctg ctggtggccg gaaggtacgg
    33781 gtggctcacg tcggcccagc tgatcgcacc ggtcgtgtcc gtccttggca tcgggaagcg
    33841 gctccacggg tgtgggcggt cggacatccc cgcgctacca ggtcttcgac tcgggaaagg
    33901 tccggagcac ccggcggcga gcgtgttccc agtaggcgcg gatcgacagg tccgcgaaga
    33961 cgaactcgcg cttcgcctcg acgtccagct cggacgaggt ggcgaagtcg cgtccggtcg
    34021 ccagcgctgt cagctggagc cggcacgccc gttcgagcat gagcgcgaag atcaccgcgt
    34081 gccgcacggt cttgccgacc actacgctgc cgtggttcac caggaacacc ccgatcccgg
    34141 agcccagcgc cgccgcgatt tccccaccgg tctcgatgtc gaggacggtg ttgctggtca
    34201 gcgtgaaccg gtcgacctca ccgcgcagca gggcgccctc gtggctgagc ggcaccagtt
    34261 cctcggccag tgccccgaac accagcgcgt ccggcgcgtg cgagtgcacg acgcagttga
    34321 cgtccgggcg cgcctggtaa atcgcttggt gcagcgggac ttccggtggt gcgaggcggt
    34381 ccggcgtggc cgccgggtcg atctcggcgg ggacgaactc ccgtggcgtc acctcgtcga
    34441 agccggtcag cgcacccttg atcaggaact cgaccgatcc cggcctgcgg caggagatct
    34501 gcccctggtt gtagtcgtcg tgaccaccca gcgacagcat ccgcgcgccg gtcgcggcct
    34561 ggaccgccag cgggtccacc gcctgagcgg tcgtctcctc ggtttttcgc agcacgaagc
    34621 aaacccccag tacgagcata ggaacgcgcc cagctcgaat cccagatcgg accacagtcg
    34681 tatggccgat gaccaaaaaa cccacaggaa cgggaaaacg cccaaatcgt tcttgcggat
    34741 cgctatcacg gatcgtactc acgcgccccc aggcactggc ccgtacgtta ccggacagag
    34801 cgacccgtac gcaagaagtg accacaatgg acagtccgca ccggaaccct ttgacctctg
    34861 cgctggcgcc ctgttacgct ccgccgccag atatcagccg actgttttcg ggcgagatcc
    34921 ccaccgagca aggatgccga ggcttgccgt gcggaaagaa gattcctggc gcgaactacg
    34981 cgtgagtagt tccgggaaag cggtcctggt ggtcgacttc gacttcaccg gccgacccga
    35041 agccaacttc gggcatttcc tggagctgct cgaacttgac cgcgggatct ggcagaccac
    35101 ccagccgccc gcagccgccc gcgagccggt accggccgag cggtacctcg atttctggtc
    35161 ccagctgccc gaggccgcca ccggccgggt ccaggcactg ctggggtact gcgtgggcgg
    35221 cgccttccta cccgcgttgg ccgaccgcct cgagcaggcc caggatgagc cgatcgacct
    35281 cgtcctgttc gacccggagc cggtcacggt ggcgagcctg cacgacgatt tccgcaagac
    35341 cgtcgacctc atgtcggccc tgtccgccga cgagaagacc gatctcgtcg cgaacgcgcg
    35401 ggaaatctgc gtaccggaag cggaattcac gtcggcggcg cggaaggtga gcgacctgta
    35461 ccgggacgcg gtcggcaccg ccttcgcccg gctggggctg gatgagtcgc tgagcgagga
    35521 gttcgtccag gtcttccagt cgtacgtgtc gtacctggcc gcggccgccg aactctcccc
    35581 gcaggacggc tgggggcgcg gtgtcgcact gacgtcgcgg gagtcgagcc ccggcgcggt
    35641 ccacgccgcg gaggagctga acttcctggt acgacccggc gatctcctcg gcgacccgcg
    35701 cgtcgccgag gccgtttccc ggatcctccg gtgaccgagc ggcggtgcgc cgaccggccg
    35761 cgctccggcg cacgcaccct ccgcgaccgg tctagaccag caccccagga cgtcggcggt
    35821 accgctccgt gccggccacc accgtcttcc cggcccgtcg gctcgcaccg gacgtgccgg
    35881 agcttccgac gtccacatcg gacgatacgg accggcctcg gctgtcacat gcggtcagct
    35941 gatcggctcc ggagcgagtg acacagatgc ggcatgctcc agggccggga tcgtttccgg
    36001 aaattacaaa ggggctgcct acctgcgtag acgaccccct catccggtcg agctgacagg
    36061 atttgaacct gcgacccctt gaccccggca ttagaggccc aagcactgta ctcaacagca
    36121 tcgttccagc tcacagagaa gcatcgcaca acgagttttg atgtccagcc aacgggcgct
    36181 acgtaagcct ctagacaccg tttggtcaag cagcaccaga acacgcaacc cccagttctc
    36241 cctcgacgac gttcacgctt aaattcgcaa tgcggagaac ccgcggtcga tgtagatccg
    36301 gccgggctcg acacccagcg cctgaagctg ctcggtctgc acgagcacgt cctgctcgtc
    36361 ggtggagcag cgcgcatacc cgactcgcgt acggggcgcc cggtcattgt cttgcgcaac
    36421 accgaactgg tctaccgcgg tcgtcgtccg gactgtccac agtagccaca ggcaggcggc
    36481 agttgctctt ggcccgcccg cggaaacggc atagcgttca atcctgccag gcccggcttg
    36541 gtatggcgtc cgttcatgag gtgggtgtga gtgcggtgag ccggtcgccg ttggagaggg
    36601 agtcggcttg tttgacttgg tggagttgca gggagatctc ggtggtgtgg actccctgca
    36661 gggcgccgat gcggtgattg atgtagcggt acaactcgtc gtgggtgcgg acgatgacga
    36721 ccgcgacgag gttttcgggc ccggcgacgg cggcgaccca ggccgtttcc ggatgttcgg
    36781 ccagggcgtg tccggtgctg tccagttggc tcggggtgac gttgagccat aggtaggcgg
    36841 tggtctgaaa gcccatgatg cgcggtgaga actcgacctc gaagtagagt gcgccgctgt
    36901 cgcggagttc ggcgattctg gtgacgaccc gggagcgggg ccagttcgtg tgggcggcga
    36961 ggtcggcgta ggcgcggcgg ccgtctgcgg cgagggcgtg cagcaacacc tcgtccccct
    37021 tccgcagcgg tcccggtgtt gtggtcgccc tggcgggcgc caaggcggcg acctggtcac
    37081 tgtccaggag gtcggggtag cccgaccagt aaagctgccc gacgtcgaac cggtgcaaca
    37141 ccgcgtagct gcggatggtg agcacctggg cggtgcgcgg caggcgttcg agcaggatct
    37201 cgttgcgtcc gtcctcgcct ggcgcacgca ccgtgcagac gagttcggaa ccgcccgcgg
    37261 tgagcccgac ccagacggct tgcgggtagc tggcgatcgt gtcggccaag gcacgggcgg
    37321 agttggggcg ggcctggacc cggatcaacc attcggtgcc gccctgccgg tgcggatcga
    37381 gccgaccgag cacgcgcagg aaccccgatc cgtgcaaccg ccggtaacga cgggcgacgg
    37441 tttgctcgga caccccgagc acggcggcga tgcggcggaa cgccgctcga ccgtcaacct
    37501 gaagcgcatg aatcatttgt cgatccagac agtccagagt ggcggcatta tcgtcaacag
    37561 ggctgctcat tggaggaact ctagcgaccg cgtcgtctga ctggcgggca tcacgcgacg
    37621 cggcgcaccg tggtcggcat gcggaagtgg ctccccttga tcccgatctc cctcggcacg
    37681 gtgatgttca ccgtcgacat caccatcatt ggcatggcga taccggcgat ctccgacggc
    37741 ctacacgtct cgttctccgc gctccaatgg tcgatcgacg cctacatcct ggtgctcgcg
    37801 gcgttggtga tggcggcggg ttcggcatcg gaccggttcg gcaggctgcg ggtctacctg
    37861 accggcactc tcgtcttcgc gatcgcatcc ctggggtgcg gcctcgcacc gaacgcggcg
    37921 gtgctgatcg ccgggcgtgc gctgcagggg gtcggtgcgg cggcgatgat ggtcacgaac
    37981 acggccctgc tggccggcac ctatcggggt cgtgaccagg gtgtggcctt cggtgtgtgg
    38041 acgtcggtga ccgccgtgtc cgcggccacc ggaccgctgc tgggcggcgt gctcaccgag
    38101 gcgctgggct ggcggtcgat cttcctggtc aacctcccga tggcactcgt cgcattgtgg
    38161 acgggacgcc gatggctgcc ggaaggccgc gacccggctg gcggccggat cgacgtgccc
    38221 ggcaccgccc tgttcgtcct cgccgccacc ttggtcacct tcgcgctgat ccgcgccggc
    38281 gaagacggct ggggcagtcc atcggtcgtg ccgtgtctcg ctgccgccgc cggcgcgctg
    38341 atcgcgttcg gcttggtcga acgacaccga cggcacccga tgctggatct ggctctgctg
    38401 cgcaaaccgg cgttcgtcgc gctcctgcta ggcgcattgg tcttcaacgc cgcgtcggtg
    38461 gccgacttcg tctaccggtc gttgtggctg cagtccatcg tgcacctcga ctcgttcgcg
    38521 gccgggctcg cactcactcc gatgggggct gccgcactgg tcacggccat gatcaccgga
    38581 cggctcgccg ccaccgtcga accccgcctg cccatcggga tcggcctgct tctgatcagc
    38641 gcgggcgggt tcagctacct gctgctgctc accccggacg cgagctggcc cgcgctgtta
    38701 cccgggttgc tgatcaccgg cgccggggtc ggcgtgtgct cacccgtact ggcgtccgcc
    38761 gtgctcgcga cggttccccc gagcagggcg ggcatggcca gcggcgcgat gaacaccttg
    38821 ctgcaactcg gattcgccct cggcatgccc gtgctcggca ccgtgctgac cgccacgatc
    38881 cgccacaccc tgaccgagac cggcttcgcc gaccccgaac ccgcggccct ggccatcagc
    38941 aacggacgtt ccccccaact ggtcgccgcc tttcccccgg gcgaccacgg ccacgtggag
    39001 agcatggcac gcgctgcctt caccaccggc ctagaacaga tcttcctctg cgacgggatc
    39061 gccgccctgg ccgccgggac ggtcgtacta gccctgatgc gacgcaagcg gcaccacaac
    39121 acccactcaa ccaccgaggc aacctcaccc tcctgacaag gcacaccgcc accagagtcg
    39181 gcgcggactt gccgaacctg ccgacggcga tcgcgacgac gttgcaggtg gacgtctcgg
    39241 cacgtccgga agctggcatg cagttcgacc gcaatcgcat cacccaaggc tcggtggcac
    39301 cgtggtcttg tcagtagaca tctgactgcc cctcctcacg aacgcctttc cgtccacatc
    39361 ggacgcagtg atgacgaagg cctcaagaag cggttcccca acgctgccga cccagttcgc
    39421 ttgaacgtgg agctattcat aaacctgcgc aacaagatcg agcaccgata cgaacccgag
    39481 ctgaagagta tgacgggcgg taaagctcag gcgttggtcg tcaactacga cgccgagttg
    39541 actgcggcgt tcgggggcaa gttcagccta gcggacaaac tgaggttccc ggtgttcttg
    39601 cacgcgctca gaccagacgg ggccgaacag ctccgagcgg ccactgcgaa ccttccacgc
    39661 ccgacgcgtg atttggtctc acggttcgag accggtatcg aacaggattt gctggacgac
    39721 ctgcggtacg acttccgaat tcgactggtt cccatcactg gacccaagac cagcgccgat
    39781 ctggccgtca acttcgtcaa actcgacgaa ctctccgacg aagagcgacg ggtcatggtc
    39841 gacgcgggcc ggacaggaac cgtcatagtc cgcgaccggc atgtcgacgt agtaagtaag
    39901 gacaagctat taccaggccg agttgcgcaa ttagtcgatt ccgcactccc cttcgaattt
    39961 tcggtcaacg cccacaccaa agtctggcaa catcttcgcg ttcgcccgcc gtgcggctcg
    40021 ttgaaaccgc acgaaaccga tgcgagatat tgcctctacg acgaaccttt tggcctctac
    40081 ccagcataag cgcggattcg cttcatgcct tgcacgccca gagcccggca gtcactcggt
    40141 cgcgaagctc cgttcgaccc cggtgtcggg tgagcggcgt tctggccgtc ggttcgggtc
    40201 gatccaggtt ccggccgcca tcgaactgga cgcgctcgat gatggcgatg acgcggtcgt
    40261 agctgggcac ggcgcgttgc cacagtgtgc ggaaccgttc ggcgtccttg cctatcggct
    40321 cgccccctct tgttcgcgcc gggctgccag gacgtgacgg agggcggcca gcgatggcgc
    40381 gttgtcgacg ctgccgtcgc tgtggcggta cagccggcag gcgatgccgg gttcgcgggc
    40441 gggctcggcg aacgggtcgg tgccgtcgat gagcagggtc ggggacccgg tcatgcccgc
    40501 cgcgatcgct tcctggtcgt cgcggacgac tcgccggtcg atccgaagcc ccggccaggt
    40561 agcgctcagc cgtacgaggt gctcgctcag aacctcggca ccgggacagc cggggacgtg
    40621 cagcacctgg accttcatgc gggctcctca ggtgttgcgc ggcggcgaga gctgcatcgt
    40681 gatctgctgg gccgcgggct cggtgttcgg ggcgcagcag gcgcagccgt cctccgtgtc
    40741 ggcttcggtg gcggggattc gttgcagggt aaggggttcc ggggcggtgg agcctcgtag
    40801 tgggcggagt cgtccggcgc ggacgccgtt gccgatgacg aagacttcgg cgagttcgtg
    40861 gatgaacacg acggtggcca ggccgaggat gccgaacgcg gcgaggggga cgagggtgag
    40921 cacgatggcc gcggacaggc cgatgttctg cagcatgatg cccctggcgc ggcgcgcgtg
    40981 gcgcacggct tggggcaggt gccgcaggtc ggtgcccatc agcgcgacgt cggcggtgtc
    41041 gatggcgacg tcgctgccca tggcgcccat cgcgatgccc acgtcggcgg tggccagcgc
    41101 gggagcgtcg ttgacgccgt cgccgaccat cgccaccgcg ccccgctcgc ggagccgttc
    41161 gacgagcgcg gccttgtcgg tcggccgcag ttcggcgtgg acgtcggcga tcccggcctg
    41221 ggtggccagc gcggcggcgg tgcgggcgtt gtcgccggtg agcatcgcga ccccgaggcc
    41281 gtccgcgcgg agctcggtga cggtctcggg cgcttcgggg cgcagttcgt cgcggatccc
    41341 gatcaggccg agcaccacgt ggtcgtgttc gatcaccgcg acggtcgtgc cggtctcctg
    41401 cagccgcgcg acgtcctcgg cgagcgggcc ggggtcgatc cagccgggtt tgccgagccg
    41461 tgccgcggcg ccgtccaccg cgccttccag tcccgcgccg gggaccgtgg tcacttcgtc
    41521 cgcggggacg ggttcggggg cggcggcgag gatcgcggcg gccagggggt gttcgctgcg
    41581 agcttccagc gcggccgcga ccgccagcac ccgctcggca gtgaggtccg gagcgggcac
    41641 gatctcggtc accgccgggg tgttgcgggt cagggtgccg gtcttgtcga gtgccacggt
    41701 gcgcaccgcg ccgagggctt ccagcgccgc accgcctttg accagcacgc cgaaccggct
    41761 ggccgcgccg accgcggcga tcacggtgac cggcacggag atcgccatcg cgcacggtgc
    41821 ggcggccacg agcacgacca gtgcccgttc gatccaggtg accggatcgc ccagcagctc
    41881 accgatcccg gcgacgagcg cggcgagcac cagcacggcg ggcaccagcg ggcgggcgat
    41941 gcggtcggcg aggcgctgcc ggtttccctt gcgctgctgg gcgtcggcga cgacgcgcac
    42001 gaccttggcc agcgagttgt cctcgacggt cgcggtcgct tggacagtga gcacgccggt
    42061 accgttgatc gcccccgcga agacctcgtc tcccggccct gcctcgaccg gcacggactc
    42121 ccccgtgatc gccgagttgt ccattgtgga ccgtccagtt cggacggtac cgtcgctggc
    42181 gaggcggtcc cccgcgcgca cgagcatgtg gtcgccgacc cgcaacgcgg tgggcgcgat
    42241 ggtggtttcc cgcccgtcac gcaggacccg gacctggtcg ggcaccagtg cgagcagcgc
    42301 gcgcagcccg cgacgggtcc gggagatcga gtagtcctcc agcgcttcgc tgatcgagaa
    42361 caggaacgcc agcatcgcgg cctcggcgaa ctgccccagc accaacgacc cggccagcgc
    42421 gatcgtcatc agggtgccga cgccgatgcg tccgcgcacc agcgcggtga gggtgccggg
    42481 cacgaaggtc cagcccccga ccgcggccgc cgccagctgc ccgccgatcc gcccgggttc
    42541 ccacccggcc caaccgcaga cgaaccccgc gaggagcaac agcccggcga ttccggcgaa
    42601 ctggatctcc cggacctgcc acaaccgttg cggcgcctcc gtttccgcgg ccgcggcgcc
    42661 ctcgggggcg tgactgtctt cgggtccgca gcacagatcg ctcataccgg atccgcctcc
    42721 gcggccagtg caagcaggtg ctgcccagcg ccggtgagcc ggtacatcac cagcttgccg
    42781 tcccggcgcg actcggccag tcccgccgaa cgcaactggc gcaagtggtg cgacaccagc
    42841 ccctgcgacg atccgacgat ccacgccaga tcgcacacgc acagctcgtc accggccagc
    42901 agcgcgtgcg cgatccgcag ccgcgtcgga tcaccgaggg cacgcaacac atcggcacgc
    42961 tgccgcagaa ccgcctcgcc gggcagggtc gtccgcaacg cctccgcgtg gtcgagatca
    43021 aggcacagca ggtcgcactg gtcatcgctc acccatacaa tctaacgccc gttgagatgt
    43081 tcgagcaaca gtgagttcgg tgaccttgtc agaagggcca gcggccggag attcggagag
    43141 cgagccgggc gtcgaggccg ccgacgcgtc ctgctgggac gaaggcgagc agtgcgaggg
    43201 ggaagaggtc ttcggcggag tattcccaga ggtaggcgcc ggcgtgccag agcatgatcc
    43261 agatcgggcc gatgagcagc agtccgccca gtgccgcgag gcgggtggcg gtgccgaggc
    43321 cgatcgcgag ttcggcggtg gtaaggacga tggcgaaggt ttcccagttc ggcaggacga
    43381 tgtcgcggta gaaatcgccc agcggcgcga tcgcggtctt gctggcggcg ttggtcgcga
    43441 tcccgcgggc ggcgtcggtg gtgatcaggt tgaaggagaa gaagccgagg tcgacgttgc
    43501 tggtgccgag cagtttcgcc agtccgttgg acagccagac caggccggtg aagatccgca
    43561 gtgcgcacgt cgcccgcgcg aatccacgag ccgggatggt cgtgctcgtg gatgactccg
    43621 ccaccgtctc gtgctgcttc gcaagacatt tgcggtcgtg acacacccac gctaagccgg
    43681 tgcggggctg agggccgggt ttcgtcagcc tttcgtgagc agcgctaggt gggaaggagt
    43741 gtggccgcga ccgcgcgcac taccgcgagt gcactgtgga caccgttgtc gacgcctttc
    43801 tcgaagtcgt cgccatcgac ggccatcgcg ttggtgacgt gtgccaggca caccacagtg
    43861 cggccgcggg ctcgcgcgta ggcgtagagg gcggcggctt ccatttctac gcacaggacc
    43921 ccgtgctcgc gggcggtgtc gatggcggtc gtggtctccc ggtagggggc gccggtgagc
    43981 ttgtcggcca cggtgggatc gaggtggctc cagcgcccga gtggcaggta gcgcaggctg
    44041 gttccctcgt cgcgcagggc gtcggtgatg agcacgaagc acggcgtgtg cggcaggtcg
    44101 gcgatctgac cggcggaggt cacgctgacc accagatcgg caccggaggc ggccagttgc
    44161 tcggccacca gtaccgcgaa gggcgcgccg acggccatgc cgacgacacc gatctccgtg
    44221 cggtcgaggt cggtggtcca catttcggtg tggtagcagg cccatcccgg gtgccgcggc
    44281 cggtcgcggc gagatggcgg acgatgtccc cgtccgggtc gagcaccgcg atcctcggca
    44341 ccggcacggt cggcagagca cgttgccggc gcgcctcccg cagcagattc cctggctcga
    44401 acaccggatg cggcctggta gtccttgccg tgagcgagcg cggcctcgtc gagggtcatg
    44461 cgatcccttc gttgtcgtgg tgcgcgacgg cacgcacgag agcatcggcc gcgatgtcga
    44521 tgtcactcga actgctccag cgccccaggg tgaggcggat cgcggccagc gcgcggtcgg
    44581 tgtcgaggtt catggcggtc aggaccgggg acggggtgtg gatgccgctg tggcaggcgg
    44641 atccggtgga ggcggcgatc tcgggcgcgt gggtgaggac gcggtggccg cgggttcggt
    44701 cgatgctgat gttgagggtg ttgggcagtc gtcgctcgac gggtccgttg aggtggatgc
    44761 gaccgggcaa ggcggtggac agccggtcgt gcaggtcgtc tcgtagcgcg gcgatccgct
    44821 ggggtgcgcc ggtggcgatg tcgtcggcgg cgagttgggc ggcggtgccg agggcgacgg
    44881 cgagtgcgac gttctcggtg cccgcgcgca gtccgcgttc ctggccaccg ccgtagacga
    44941 ccggttccag ggcaacacca tcgcggacgt agagcgcggc ggcgccgcgg ggcgcgtaca
    45001 tcttgtgccc gaccacggtc agcaggtcca cagtggactc ggtgacgtcg accgggattt
    45061 tcccgcacgc ttgcgcggcg tcgcagtgca cgagtgcgcc atggcgatgg gcgacggtgg
    45121 cgagttcggt gatcggctgc agcgcgccgg tttcgttgtt ggcggccatg atcgacacca
    45181 cggccggacc cggcccggcg accagcgcgg cgtcgagtgc gacgggggcg agcagcccgt
    45241 cgtggtcgac ggggagcacg gtgacttcgg tgccgtgcag gcgttcgagc gcctgggcgg
    45301 tctgcaggac cgcggggtgc tcagtggccg cgatgaccag gtgaccgcgt ccgtcgccga
    45361 gcacggctcc ccgcaaggcg agaaggttcg cctccgatcc ggacgcggtg aacacgatct
    45421 catccgctcg cgcgccgagc agtgcagcga cctgttcgcg cgcggtggcg agggcgtggc
    45481 gtggccgatc ggcgtagggg tggtcgctgg aggggttgcc gaagaattcc gtccagtacg
    45541 gcatcgccgc gtcggtgacg cgcgggtcga ccggggtggt cgcgttgtag tccaggtaga
    45601 ccggcccgcc ggggttcacg cgcgatcccc gatggcgacg ggcagttcgg cgaggcgcca
    45661 ttcgagcatg ccgtcgtgca ggcggatcgc gcggcggccg cgatcgatga gcagccggac
    45721 ggcgtcgtag gccagcacgc agtattcgcc gcggcagtag acgacgatct cggtctcctc
    45781 gggcagttcg gcgacccggt cagccaactc gtgcaccgga atgctgaccg cgccggggat
    45841 gtgccctgct cggtactcgt gaaccggccg cacgtccagc accacgacct cccccgcctt
    45901 cgcacgggca cgcagttgcg cccggctgat ctcggtgtca ccgccggggc cgaggaaggc
    45961 gtcgcgggcg gcgggcaccg cgggctggtg ggcctgggcg accttgcgta gtaaggcaaa
    46021 gagctgtgcg acgtcggcgc ccgcgagccg gtagtgcacc cgcaccccgt cgcggcgggt
    46081 ggtcacgaac ccggcctgct tgagggtctg cagatgcgcc gacgccgtcg tcaggttcag
    46141 cccggccgcc gaggcgagcg cgtcgacggt ccgttcgcct tgcgcgagca ggtccagcag
    46201 ttccaggcgc gtgccgttgg ccagtgcttt cccgctgacc gcgaaggcct cgtacagccg
    46261 cgctttcgtc gcttcctctg ccaccatcac ttcctccata attccatgga ataatgtata
    46321 gcaggatcac gacacgaagg gcacctctgt gactgcactg cggcgatggg cggacgcgct
    46381 cgcgtcctgg gcgatcccac cggagatcct ggccgacgca cccgagtcgc catgggtgct
    46441 gccacggcag gtgttcaccc gccgcgccga cgcgcaactc gcgcacccgt ccggcgcgac
    46501 gcacaccgcc gcgctcgaag cgctgaccga acccgggtcg gtactcgaca tcggcgcggc
    46561 ggcaggggcg acgagcctgc cactgctcgg gcgagcaccc gtgcgggaac ttgcggccgt
    46621 ggacgccgac gccgaactgc tcaccgcgtt cgccgagcgc accaccgcac tggacagccc
    46681 cgcgaagatc cactgtggac gg
//
