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Overview
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1.17

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP076103.1 (Lysobacter capsici)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | lanthipeptide-class-ii | 692,487 | 731,457 |
Region 2 | terpene-precursor | 2,015,717 | 2,036,613 |
Region 3 | RiPP-like | 2,091,352 | 2,102,236 |
Region 4 | NRPS,T1PKS | 2,180,198 | 2,229,686 | High | heat-stable antifungal factor | NRPS:Type I+PKS
Region 5 | lanthipeptide-class-iii | 2,513,316 | 2,536,054 | Low | Le-pyrrolopyrazines | NRPS:Type I
Region 6 | NRPS,NRP-metallophore | 3,081,970 | 3,185,537 | Low | WAP-8294A2 | NRPS:Type I
Region 7 | PKS-like | 3,680,815 | 3,721,807 |
Region 8 | lanthipeptide-class-ii | 4,150,287 | 4,173,157 |
Region 9 | redox-cofactor | 4,428,801 | 4,451,018 |
Region 10 | RiPP-like | 5,077,931 | 5,089,202 |
Region 11 | RiPP-like | 5,143,024 | 5,154,295 |
Region 12 | lanthipeptide-class-ii | 5,463,847 | 5,486,711 |
Region 13 | NRPS | 5,617,668 | 5,688,221 |  |
Region 14 | arylpolyene | 5,748,863 | 5,790,068 | Medium | xanthomonadin I | other:other
Region 15 | NRPS | 6,024,168 | 6,068,031 |
Region 16 | RiPP-like | 6,180,782 | 6,191,633 |
Region 17 | RiPP-like | 6,207,937 | 6,219,196 |

NZ_CP076103.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 692,487 - 731,457 nt. (total: 38,971 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
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zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
KME82_RS02900: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Lyases: cyclase
KME82_RS02875: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

KME82_RS02930: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: ligase
KME82_RS02905: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.55 | NRPS | AM-toxin | Alternaria alternata
BGC0001641.4 |  | 0.55 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000517.4 |  | 0.50 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002703.2 |  | 0.49 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001576.3 |  | 0.46 | ribosomal | divamide A | Prochloron didemni
BGC0002704.2 |  | 0.46 | ribosomal | archalan β | Halorussus salinus
BGC0000528.5 |  | 0.45 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.55 | NRPS | AM-toxin | Alternaria alternata
BGC0001641.4 |  | 0.55 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000517.4 |  | 0.50 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002703.2 |  | 0.49 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001576.3 |  | 0.46 | ribosomal | divamide A | Prochloron didemni
BGC0002704.2 |  | 0.46 | ribosomal | archalan β | Halorussus salinus
BGC0000528.5 |  | 0.45 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KME82_RS02875

KME82_RS02870
Leader:
MSDVSEGA
Core:
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C A
Core with dehydrations:
A L V A Q W R Dhb D A E Dha N N P A G P L F I G G E Y V E Dha D I I G E V A P A I Dhb G Cys Dha L Cys Dhb G Dha I R I N Cys Cys A

#### antiSMASH-DB 4.0 matches for KME82_RS02870

100.0%
NZ_CP076103.1:
Lanthipeptides: KME82_RS02870_lanthipeptide
1
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C A
54
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C A
1
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C A
54
98.1%
NZ_CP011130.1 and 4 others:
NZ_CP023465.1 Lanthipeptides: CNO08_RS25510_lanthipeptide NZ_CP094357.1 Lanthipeptides: IEQ11_RS02795_lanthipeptide NZ_KQ061218.1 Lanthipeptides: WN54_RS23295_lanthipeptide NZ_LMHM01000017.1 Lanthipeptides: ASD86_RS21560_lanthipeptide
Lanthipeptides: LC55x_RS02840_lanthipeptide
1
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C A
54
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S+R I N C C A
1
A L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S M R I N C C A
54
53.7%
NZ_JAIQCM010000003.1:
Lanthipeptides: K9V56_RS08295_lanthipeptide
2
L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C-S L C T G S I R I N C C
53
L V A Q W R+ A+ +N P A G P L F I G G E Y E+D I+G+ + C + C+G S C C
1
L V A Q W R S Q A D G S N P A G P L F I G G E Y A E A D I V G D T S T I S G K C G T A C S G S R T R M C C
53
with 81 more sequence matches
Only the first 10 are displayed here.
51.9%
NZ_CP012109.1:
Lanthipeptides: A176_RS18020_lanthipeptide
2
L V A Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L-C T G S I R I N C C
53
L V Q W R A+ +N P A G P L F+G G E+ E S D I I E C C+G S C C
2
L V E Q W R N S A D K S N P A G P L F V G G E F T E S D I I H E T I V I S G R C G T G C S G S Q T R Q C C
54
50.0%
NZ_JACHYJ010000001.1:
Lanthipeptides: FHW73_RS02140_lanthipeptide
13
N N P A G P L F I G G E Y V E S D I I-G E V A P A I---T G C S L C T G S I R I N C
52
+N P A G L F I G G E Y E+D I G+V A + T C+ C T G S I I N C
1
D N P A G A L F I G G E Y A E A D I A G G D V A M T V F N C T N C A D C T G S I T I N C
44
48.1%
NZ_AP014940.1:
Lanthipeptides: LEN_RS25395_lanthipeptide
6
W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C
53
W R +A S+N P A G P L F I G G E+ E+D I G+ S+C T G I C C
1
W R N E A G S D N P A G P L F I G G E F A E A D I A G D S E A I S M I T S V C T G C G T I Q C C
48
48.1%
NZ_CP040709.1:
Lanthipeptides: FF090_RS18940_lanthipeptide
5
Q W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C-S L C T G S I R I N C C
53
+W R+ A+++N P A G P L F I G G E Y E+D I I G+ C + C+G S C C
1
E W R S Q A D A S N P A G P L F I G G E Y A E A D I I G D T T S I S G K C G T A C S G S R T R M C C
50
48.1%
NZ_FNOG01000007.1:
Lanthipeptides: BLU84_RS27270_lanthipeptide
6
W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C
53
W R +A S+N P A G P L F I G G E+ E+D I G+ S+C T G I+C C
1
W R N E A G S D N P A G P L F I G G E F A E A D I A G D S E A V S M I T S V C T G C G T I H C C
48
46.3%
NZ_CP072597.1:
Lanthipeptides: J5226_RS01600_lanthipeptide
6
W R T D A E S N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C
53
W R D A ++N P A G P L F I G E+ E+D I G+ S C T G I C C
1
W R N D A G A D N P A G P L F I S G E F A E A D I A G D N E I I S R N T S A C T G C G T I Q C C
48
44.4%
NZ_CP069338.1:
Lanthipeptides: JQX13_RS07220_lanthipeptide
6
W R T D A E S----N N P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C
53
W + +E S N N P A G P L++G G E E+ + T G C S C T G S+ C C
1
W L S G S E S A F G M N N P A G P L Y L G G E A T E A A L T N S T D A L Y T G C S S C T G S L H S Y C C
52
44.4%
NZ_JABBWY010000002.1:
Lanthipeptides: HHX37_RS08020_lanthipeptide
6
W R T D A E S N N---P A G P L F I G G E Y V E S D I I G E V A P A I T G C S L C T G S I R I N C C
53
W R+ A+ P A G P L F I G E Y E S+I A S C T G+ I C C
1
W R S G A D V E G W D C P A G P L F I-G E Y A E S E I T-L T A L D T R R P S S C T G A N T I P C C
49
42.6%
NZ_CP071090.1:
Lanthipeptides: JY651_RS36970_lanthipeptide
6
W R T D A E S----N N P A G P L F I G G E Y V E S D I I G E V A P A I-T G C S L C T G S I R I N C C
53
W + +E S N P A G P L++G G E+ + + A P + T G C S+C T S + C C
1
W L S G S E S V D G L A N P A G P L Y V G G T A T E A A L T-D A A P M M G T G C S I C T A S R P V V C C
52
39.0%
NZ_AP023359.1:
Lanthipeptides: Prubr_RS34935_lanthipeptide
6
W R T D A E S----N N P A G P L F I G G E Y V E S D I I G E V A P---A I T G C S L C T G S I
48
W T E N P A G P L F+G G+Y E+D I + ++T G C C+G S I
1
W L T G T E P V D G W E N P A G P L F L G G K Y A E A D I T A T G S G G S N S V T G C G W C S G S I
50
allorf_0701949_0702044
Leader:
MRSRSVPGV
Core:
A A C R M D A R R L S C T S T A V D A T K E
Core with dehydrations:
A A Cys R M D A R R L Dha Cys Dhb Dha Dhb A V D A Dhb K E

#### antiSMASH-DB 4.0 matches for allorf_0701949_0702044

16.7%
NZ_AP017375.1:
Lanthipeptides: STA3757_RS16550_lanthipeptide
1
A A C R M D A R R L S C T S T A V D A T
20
C+++++ + C S A T
10
G G C Q I N S Q S I V C L S A A G G G T
29
10.2%
NZ_BROP01000004.1:
Lanthipeptides: allorf_014630_014866_lanthipeptide
7
A R R L S C T S T A V D A T K
21
R R L S C S + +
34
P R R L S C L S V P I S L S P
48

#### MIBiG 4.0 matches for allorf_0701949_0702044

17.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
2
A C R M D A R R L S C T S T A
16
+C R+ + C T T
7
S C R L G N K G A Y C T L T V
21
allorf_0708339_0708488
Leader:
MTAQGAAVIGC
Core:
M P R R V R P E P R T A P P I G A V C R K Q H S G H A P G G F Y V C S T A H
Core with dehydrations:
M P R R V R P E P R Dhb A P P I G A V Cys R K Q H Dha G H A P G G F Y V Cys Dha Dhb A H

#### antiSMASH-DB 4.0 matches for allorf_0708339_0708488

26.3%
NZ_CP102415.1:
Lanthipeptides: allorf_0035355_0035579_lanthipeptide
3
R R V R P E P R T A P P I G A V C R
20
R R+R P+P +P G A V R
3
R R I R P Q P T P S P R P G A V I R
20
23.7%
NZ_JAPVBQ010000001.1:
Lanthipeptides: O2V63_RS05740_lanthipeptide
10
R T A P P I G A V C--R K Q H S G H A P G G F Y
32
+T +G A V C + S G G F+
12
K T T K T V G A V C T I S W E C S G R I C G I F W
36
17.4%
NZ_CP011130.1 and 1 other:
NZ_CP094357.1 Lanthipeptides: allorf_0702749_0702910_lanthipeptide
Lanthipeptides: allorf_0736143_0736304_lanthipeptide
22
Q H S G H A P G G F Y V C S T
36
Q S H A P F+ C T
14
Q A S A H A P S A F F A C W T
28
allorf_0713923_0714084
Leader:
MSGLRGGARASSDRAGA
Core:
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
Core with dehydrations:
N P R Q R Dha P D A G R E P Cys I R A P G A Dhb R P D A Dha V R Dhb H Y W Dha I G G

#### antiSMASH-DB 4.0 matches for allorf_0713923_0714084

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_0713923_0714084_lanthipeptide
1
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
36
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
1
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
36
26.8%
NZ_MCIF01000002.1:
Lanthipeptides: allorf_2113114_2113341_lanthipeptide
7
P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G
35
P D G R + G A T R A R ++G
9
P D G G R V I T L V D L G A T R R G A G G R R A Q C A V G
37
25.0%
NZ_LR655208.1:
Lanthipeptides: FS985_RS23940_lanthipeptide
14
C I R A P G A T R P D A S V R T H Y
31
C++ A T P D V R T H+
15
C V K T N E A T C P D D C V R T H F
32
with 22 more sequence matches
Only the first 10 are displayed here.
22.2%
NZ_CP030028.1:
Lassopeptides: DOE78_RS20570_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I+ P A++P D H Y
2
P G I K T P D A S Q P D V D E V V H Y
20
22.2%
NZ_CP095550.1:
Lassopeptides: MVE64_RS05235_lassopeptide
13
P C I R A P G A T R P D A S V R T H
30
P I R P A +P D H
2
P G I R T P D A V Q P D P D A H E H
19
22.2%
NZ_CP096019.1:
Lanthipeptides: allorf_1451265_1451483_lanthipeptide
3
R Q R S P D A G R E P C I R A P G
19
R R S A C+R P G
6
R F R S S Y A E E V S C L R T P G
22
22.2%
NZ_CP104558.1:
Lassopeptides: N5C46_RS13530_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I R P +P D H Y
2
P G I R T P D G V Q P D V D E V V H Y
20
22.2%
NZ_CP115450.1:
Lanthipeptides: allorf_7944918_7945079_lanthipeptide
9
A G R E P C I R A P G A
20
A G R E P C P A
13
A G R E P C A P G P A A
24
22.2%
NZ_JAIEZS010000055.1 and 1 other:
NZ_JH792165.1 Lassopeptides: IIO_RS35460_lassopeptide
Lassopeptides: K0820_RS18465_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I+ P A +P D H Y
2
P G I K T P D A V Q P D V D E V V H Y
20
22.2%
NZ_JAQQWU010000003.1:
Lassopeptides: PQ511_RS07455_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I+ P A +P D H Y
2
P G I K T P D A V Q P D V D E A V H Y
20
22.2%
NZ_OX216966.1:
Lassopeptides: NNL35_RS04670_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y W S
33
P P A +P D H Y S
2
P G T S T P D A F Q P D P D E D V H Y D S
22
22.2%
NZ_SDLR01000004.1:
Lassopeptides: EIZ58_RS19635_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y W S
33
P + P A +P D H Y S
2
P G V T T P D A F Q P D P D E T I H Y E S
22
19.4%
NC_017138.1 and 11 others:
NZ_CP018874.1 Lassopeptides: BUW91_RS28875_lassopeptide NZ_CP028084.1 Lassopeptides: C1N54_RS05380_lassopeptide NZ_JANIOE010000001.1 Lassopeptides: NQ109_RS19625_lassopeptide NZ_NGUL01000003.1 Lassopeptides: CBE78_RS15420_lassopeptide NZ_NTZG01000008.1 Lassopeptides: CN510_RS30020_lassopeptide NZ_NUEC01000009.1 Lassopeptides: CN635_RS27505_lassopeptide NZ_NUOI01000031.1 Lassopeptides: COE08_RS30705_lassopeptide NZ_NVEG01000005.1 Lassopeptides: COL08_RS29985_lassopeptide NZ_NVEV01000001.1 Lassopeptides: COL23_RS28065_lassopeptide NZ_VDTN01000001.1 Lassopeptides: FS483_RS07665_lassopeptide NZ_VEEA01000001.1 Lassopeptides: FS744_RS11845_lassopeptide
Lassopeptides: BMWSH_RS26600_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P P A +P D H Y
2
P G T S I P D A V Q P D P D E T V H Y
20

#### Lanthipeptide(s) for KME82_RS02930

KME82_RS02935
Leader:
MQNNDDVVSGWLNGSDSIDGQDNPAGSLYIEGQAVAEAALGSTDMRATLGA
Core:
C G T L G K T T C S F G G G C A C C
Core with dehydrations:
Cys G Dhb L G K Dhb Dhb Cys Dha F G G G Cys A Cys Cys

#### antiSMASH-DB 4.0 matches for KME82_RS02935

100.0%
NZ_CP076103.1:
Lanthipeptides: KME82_RS02935_lanthipeptide
1
C G T L G K T T C S F G G G C A C C
18
C G T L G K T T C S F G G G C A C C
1
C G T L G K T T C S F G G G C A C C
18
94.4%
NZ_LMHM01000017.1:
Lanthipeptides: ASD86_RS21615_lanthipeptide
1
C G T L G K T T C S F G G G C A C C
18
C G T L G K T T C S+G G G C A C C
1
C G T L G K T T C S Y G G G C A C C
18
72.2%
NZ_CP110813.1:
Lanthipeptides: BV903_RS23035_lanthipeptide
1
C G T L G K T T C S F G G G C A C C
18
C G T L G T+C S+ G G C C C
1
C G T L G G T S C S Y N G G C L C C
18
with 11 more sequence matches
Only the first 10 are displayed here.
72.2%
NZ_FNPT01000006.1:
Lanthipeptides: BLV01_RS12410_lanthipeptide
1
C G T L G K T T C S F G G G C A C C
18
C G T L G T+C S+ G G C C C
1
C G T L G G T S C S Y A G G C L C C
18
66.7%
NZ_JALBFU010000002.1:
Lanthipeptides: MD221_RS08055_lanthipeptide
7
T T C S F G G G C A C C
18
T T C S F G G G C A C C
1
T T C S F G G G C A C C
12
39.3%
NZ_JACCCA010000013.1 and 2 others:
NZ_JACHCM010000004.1 Lanthipeptides: HDE76_RS13915_lanthipeptide NZ_JACHCP010000005.1 Lanthipeptides: HDE80_RS12415_lanthipeptide
Lanthipeptides: HDE78_RS21145_lanthipeptide
5
G K T T C S F G G G C A C C
18
G T T C S G G C A C C
15
G S T T C S V A G G C A C C
28
35.7%
NZ_CP011130.1 and 1 other:
NZ_KQ061218.1 Lanthipeptides: WN54_RS23350_lanthipeptide
Lanthipeptides: LC55x_RS02895_lanthipeptide
1
C G T L G K T T C S F G G G C A C C
18
C G T L G T T C S+G G G C C C
25
C G T L G G T T C S Y G G G C L C C
42
35.5%
NZ_BMJA01000001.1:
Lanthipeptides: IEX75_RS00910_lanthipeptide
5
G K T T C S F G G-----G C A C C
18
G T T C S F G C A C C
13
G A T T C S F S G K I C A S S C A C C
31
33.3%
NZ_CP023465.1 and 1 other:
NZ_CP094357.1 Lanthipeptides: IEQ11_RS02850_lanthipeptide
Lanthipeptides: CNO08_RS02770_lanthipeptide
1
C G T L G K T T C S F G G G C A C C
18
C G T G T T C S+G G G C C C
25
C G T F G G T T C S Y G G G C L C C
42
23.3%
NZ_PVRU01000017.1 and 1 other:
NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28285_lanthipeptide
Lanthipeptides: C6360_RS28285_lanthipeptide
6
K T T C S F G G G C A C
17
+T T +F G G G A
6
E T T P A F G G G V A L
17
23.3%
NZ_PVRU01000017.1 and 1 other:
NZ_PVRU01000017.1 Lanthipeptides: C6360_RS28280_lanthipeptide
Lanthipeptides: C6360_RS28280_lanthipeptide
6
K T T C S F G G G C A C C
18
+T T +F G G G A
6
E T T P A F G G G V A L S
18
19.2%
NZ_CP089414.1:
Lanthipeptides: DYST_RS04430_lanthipeptide
7
T T C S F---G G G C A C C
18
+T C S G G G C A C C
38
S T C S I H T S G G G C A C C
52
18.2%
NZ_RYYV01000004.1:
Lanthipeptides: allorf_108254_108448_lanthipeptide
3
T L G K T T C S F G G G C A C C
18
T+ +T T S G C+C C
29
T M F R T T Q S C A S G C S C C
44
allorf_0713923_0714084
Leader:
MSGLRGGARASSDRAGA
Core:
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
Core with dehydrations:
N P R Q R Dha P D A G R E P Cys I R A P G A Dhb R P D A Dha V R Dhb H Y W Dha I G G

#### antiSMASH-DB 4.0 matches for allorf_0713923_0714084

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_0713923_0714084_lanthipeptide
1
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
36
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
1
N P R Q R S P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G G
36
26.8%
NZ_MCIF01000002.1:
Lanthipeptides: allorf_2113114_2113341_lanthipeptide
7
P D A G R E P C I R A P G A T R P D A S V R T H Y W S I G
35
P D G R + G A T R A R ++G
9
P D G G R V I T L V D L G A T R R G A G G R R A Q C A V G
37
25.0%
NZ_LR655208.1:
Lanthipeptides: FS985_RS23940_lanthipeptide
14
C I R A P G A T R P D A S V R T H Y
31
C++ A T P D V R T H+
15
C V K T N E A T C P D D C V R T H F
32
with 22 more sequence matches
Only the first 10 are displayed here.
22.2%
NZ_CP030028.1:
Lassopeptides: DOE78_RS20570_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I+ P A++P D H Y
2
P G I K T P D A S Q P D V D E V V H Y
20
22.2%
NZ_CP095550.1:
Lassopeptides: MVE64_RS05235_lassopeptide
13
P C I R A P G A T R P D A S V R T H
30
P I R P A +P D H
2
P G I R T P D A V Q P D P D A H E H
19
22.2%
NZ_CP096019.1:
Lanthipeptides: allorf_1451265_1451483_lanthipeptide
3
R Q R S P D A G R E P C I R A P G
19
R R S A C+R P G
6
R F R S S Y A E E V S C L R T P G
22
22.2%
NZ_CP104558.1:
Lassopeptides: N5C46_RS13530_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I R P +P D H Y
2
P G I R T P D G V Q P D V D E V V H Y
20
22.2%
NZ_CP115450.1:
Lanthipeptides: allorf_7944918_7945079_lanthipeptide
9
A G R E P C I R A P G A
20
A G R E P C P A
13
A G R E P C A P G P A A
24
22.2%
NZ_JAIEZS010000055.1 and 1 other:
NZ_JH792165.1 Lassopeptides: IIO_RS35460_lassopeptide
Lassopeptides: K0820_RS18465_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I+ P A +P D H Y
2
P G I K T P D A V Q P D V D E V V H Y
20
22.2%
NZ_JAQQWU010000003.1:
Lassopeptides: PQ511_RS07455_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P I+ P A +P D H Y
2
P G I K T P D A V Q P D V D E A V H Y
20
22.2%
NZ_OX216966.1:
Lassopeptides: NNL35_RS04670_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y W S
33
P P A +P D H Y S
2
P G T S T P D A F Q P D P D E D V H Y D S
22
22.2%
NZ_SDLR01000004.1:
Lassopeptides: EIZ58_RS19635_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y W S
33
P + P A +P D H Y S
2
P G V T T P D A F Q P D P D E T I H Y E S
22
19.4%
NC_017138.1 and 11 others:
NZ_CP018874.1 Lassopeptides: BUW91_RS28875_lassopeptide NZ_CP028084.1 Lassopeptides: C1N54_RS05380_lassopeptide NZ_JANIOE010000001.1 Lassopeptides: NQ109_RS19625_lassopeptide NZ_NGUL01000003.1 Lassopeptides: CBE78_RS15420_lassopeptide NZ_NTZG01000008.1 Lassopeptides: CN510_RS30020_lassopeptide NZ_NUEC01000009.1 Lassopeptides: CN635_RS27505_lassopeptide NZ_NUOI01000031.1 Lassopeptides: COE08_RS30705_lassopeptide NZ_NVEG01000005.1 Lassopeptides: COL08_RS29985_lassopeptide NZ_NVEV01000001.1 Lassopeptides: COL23_RS28065_lassopeptide NZ_VDTN01000001.1 Lassopeptides: FS483_RS07665_lassopeptide NZ_VEEA01000001.1 Lassopeptides: FS744_RS11845_lassopeptide
Lassopeptides: BMWSH_RS26600_lassopeptide
13
P C I R A P G A T R P D A S V R T H Y
31
P P A +P D H Y
2
P G T S I P D A V Q P D P D E T V H Y
20
allorf_0721912_0722004
Leader:
MRFARSVAVRCHNASCRHSQSLAG
Core:
C R R R T R
Core with dehydrations:
Cys R R R Dhb R
allorf_0722572_0722688
Leader:
MTRLRRTPGFIDVIGG
Core:
R F A T Q C R R P T R T A S I K R K N P M A
Core with dehydrations:
R F A Dhb Q Cys R R P Dhb R Dhb A Dha I K R K N P M A

#### antiSMASH-DB 4.0 matches for allorf_0722572_0722688

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_0722572_0722688_lanthipeptide
1
R F A T Q C R R P T R T A S I K R K N P M A
22
R F A T Q C R R P T R T A S I K R K N P M A
1
R F A T Q C R R P T R T A S I K R K N P M A
22
24.1%
NZ_CP070973.1:
Lanthipeptides: allorf_2137977_2138177_lanthipeptide
1
R F A T Q C R R P T R T A S
14
R A T C R P A+
15
R V A T G C R T P A S A A A
28
21.4%
NZ_CP067395.1:
Lanthipeptides: allorf_4557282_4557398_lanthipeptide
5
Q C R R P T R T A S
14
+C R P T R S
17
E C R D P T R A V S
26
with 1 more sequence matches
9.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: allorf_26709_26948_lanthipeptide
Lanthipeptides: allorf_26709_26948_lanthipeptide
2
F A T Q C R R P T R T A S I K R K N P M A
22
++ C+ +R A S+ +P+A
44
Y S A P C Q P S S R A A S V P A D S P L A
64
allorf_0730236_0730388
Leader:
MSRSCMPACNGARTQSVLQRKNELMSSTTM
Core:
Q F Q I V A S T G S G F A F A R V C T N
Core with dehydrations:
Q F Q I V A Dha Dhb G Dha G F A F A R V Cys Dhb N

#### antiSMASH-DB 4.0 matches for allorf_0730236_0730388

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_0730236_0730388_lanthipeptide
1
Q F Q I V A S T G S G F A F A R V C T N
20
Q F Q I V A S T G S G F A F A R V C T N
1
Q F Q I V A S T G S G F A F A R V C T N
20
45.0%
NZ_CP011130.1 and 4 others:
NZ_CP023465.1 Lanthipeptides: allorf_0709374_0709463_lanthipeptide NZ_CP094357.1 Lanthipeptides: allorf_0710411_0710500_lanthipeptide NZ_KQ061218.1 Lanthipeptides: allorf_241583_241672_lanthipeptide NZ_LMHM01000017.1 Lanthipeptides: allorf_240464_240658_lanthipeptide
Lanthipeptides: allorf_0743805_0743939_lanthipeptide
11
G F A F A R V C T N
20
G F A A R V C T N
1
G F A C A R V C T N
10
20.8%
NZ_JHEG04000001.1 and 9 others:
NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12620_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12615_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12610_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12605_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12600_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12595_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12590_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12585_lanthipeptide NZ_JHEG04000001.1 Lanthipeptides: HC643_RS12580_lanthipeptide
Lanthipeptides: HC643_RS12630_lanthipeptide
11
G F A F A R V C T
19
G++F A+V C
4
G W S F A K V C V
12
with 1 more sequence matches
20.8%
NZ_JXCA02000027.1:
Lanthipeptides: SD80_RS29260_lanthipeptide
11
G F A F A R V C
18
G++F A+V C
4
G W S F A K V C
11
allorf_0730321_0730554
Leader:
MRATSKQAPTRRRARTYARTCAAA
Core:
R T Y P A R L S A R P R M T R R S A T R S R M P A P A C L H P H E P L M H A C L Q W R A N T I G V A A Q K
Core with dehydrations:
R Dhb Y P A R L Dha A R P R M Dhb R R Dha A Dhb R Dha R M P A P A Cys L H P H E P L M H A Cys L Q W R A N Dhb I G V A A Q K

#### antiSMASH-DB 4.0 matches for allorf_0730321_0730554

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_0730321_0730554_lanthipeptide
1
R T Y P A R L S A R P R M T R R S A T R S R M P A P A C L H P H E P L M H A C L Q W R A N T I G V A A Q K
53
R T Y P A R L S A R P R M T R R S A T R S R M P A P A C L H P H E P L M H A C L Q W R A N T I G V A A Q K
1
R T Y P A R L S A R P R M T R R S A T R S R M P A P A C L H P H E P L M H A C L Q W R A N T I G V A A Q K
53
24.5%
NZ_CP041244.1:
Lanthipeptides: allorf_9037860_9038039_lanthipeptide
4
P A R L S A R P R M T R R S A T R S R M P A P A C L H P H E P L
35
P R L S+ P R R R+R A C H L
6
P R R L S S N P R A G R G V T C R A R----A C Q A T H R S L
33
18.9%
NZ_QRDO01000002.1:
Lanthipeptides: allorf_1072387_1072554_lanthipeptide
8
S A R P R M T R R S A T R S R M P A P A C L H P H E P L M
36
+A R R+ + A + M P A + P H P++
8
A A R C R V P Q S C A L H A G M P T K A A M G P H R P M L
36
with 1 more sequence matches
17.0%
NZ_QJTF01000024.1:
Lanthipeptides: allorf_35922_36149_lanthipeptide
26
P A C L H P H E P L M H A C L Q W R A N
45
P C H +A C L Q R N
3
P L C T G D H T Y C W N A C L Q S R R N
22
allorf_0730385_0730594
Leader:
MLRRKAGFIGCRARACNFEASTDTPSRANVRAYLRGCAYLPSAPERAPAHDAPVRDALAHA
Core:
R T C M P A P A
Core with dehydrations:
R Dhb Cys M P A P A

#### antiSMASH-DB 4.0 matches for allorf_0730385_0730594

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_0730385_0730594_lanthipeptide
1
R T C M P A P A
8
R T C M P A P A
1
R T C M P A P A
8

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.96 out of 23.79
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
Additional weak hits (5):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.04 out of 20.01
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.94 out of 32.74
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.97 out of 30.97
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.04 out of 35.63
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KME82_RS02935 - Class II
  Cleavage pHMM score: -4.30
  RODEO score: 0
  Monoisotopic mass: 1595.6 Da
  Molecular weight: 1596.9 Da
  Number of bridges: 4
allorf_0713923_0714084 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 3841.0 Da
  Molecular weight: 3843.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3861.2 Da N = 1
    3879.2 Da N = 2
    3897.3 Da N = 3
    3915.3 Da N = 4
allorf_0721912_0722004 - Class II
  Cleavage pHMM score: -4.90
  RODEO score: 0
  Monoisotopic mass: 828.5 Da
  Molecular weight: 829.0 Da
  Number of bridges: 1
allorf_0722572_0722688 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 2516.4 Da
  Molecular weight: 2518.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2536.0 Da N = 1
    2554.0 Da N = 2
    2572.0 Da N = 3
allorf_0730236_0730388 - Class II
  Cleavage pHMM score: -5.50
  RODEO score: 0
  Monoisotopic mass: 2031.0 Da
  Molecular weight: 2032.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2050.3 Da N = 1
    2068.3 Da N = 2
    2086.3 Da N = 3
allorf_0730321_0730554 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 5892.1 Da
  Molecular weight: 5895.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5913.9 Da N = 1
    5931.9 Da N = 2
    5949.9 Da N = 3
    5968.0 Da N = 4
    5986.0 Da N = 5
allorf_0730385_0730594 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 827.4 Da
  Molecular weight: 828.0 Da
  Number of bridges: 1
KME82_RS02870 - Class II
  Cleavage pHMM score: -4.40
  RODEO score: 0
  Monoisotopic mass: 5425.7 Da
  Molecular weight: 5429.1 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5447.1 Da N = 1
    5465.1 Da N = 2
    5483.1 Da N = 3
allorf_0701949_0702044 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 2265.1 Da
  Molecular weight: 2266.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2284.6 Da N = 1
    2302.6 Da N = 2
    2320.6 Da N = 3
allorf_0708339_0708488 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 4051.1 Da
  Molecular weight: 4053.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4071.7 Da N = 1
    4089.7 Da N = 2
allorf_0713923_0714084 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 3841.0 Da
  Molecular weight: 3843.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3861.2 Da N = 1
    3879.2 Da N = 2
    3897.3 Da N = 3
    3915.3 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
IolR | Regulator of the inositol catabolism
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP076103.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,015,717 - 2,036,613 nt. (total: 20,897 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
KME82_RS08420: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: transferase
KME82_RS08430: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Ligases: synthetase
KME82_RS08405: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000642.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000635.3 |  | 0.37 | terpene | carotenoid | Paracoccus sp. N81106

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000642.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000635.3 |  | 0.37 | terpene | carotenoid | Paracoccus sp. N81106

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
KME82_RS08405: PT_FPPS_like
Domain 1 (36 - 297): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 25.31
Confidence: medium
Additional weak hits (37):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.30 out of 23.43
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.90 out of 20.01
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.89 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.82 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.59 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_CP076103.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,091,352 - 2,102,236 nt. (total: 10,885 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.5 |  | 0.30 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000188.5 |  | 0.27 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0002046.3 |  | 0.27 | NRPS, PKS | lobatamide A | Gynuella sunshinyii YC6258
BGC0002012.4 |  | 0.22 | PKS | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0000344.5 |  | 0.20 | NRPS | entolysin | Pseudomonas entomophila L48
BGC0000651.5 |  | 0.20 | terpene | KS-505a | Streptomyces argenteolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.5 |  | 0.30 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000188.5 |  | 0.27 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0002046.3 |  | 0.27 | NRPS, PKS | lobatamide A | Gynuella sunshinyii YC6258
BGC0002012.4 |  | 0.22 | PKS | julichrome Q3-3, julichrome Q3-5 | Streptomyces afghaniensis 772
BGC0000344.5 |  | 0.20 | NRPS | entolysin | Pseudomonas entomophila L48
BGC0000651.5 |  | 0.20 | terpene | KS-505a | Streptomyces argenteolus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.64 out of 26.85
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
Additional weak hits (7):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.79 out of 27.78
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.04 out of 21.84
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.79 out of 30.22
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.50 out of 21.55
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.38 out of 20.97
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.03 out of 29.65
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.06 out of 20.01
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
RutR | Regulator of the pyrimidine and purine metabolism

NZ_CP076103.1 - Region 4 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,180,198 - 2,229,686 nt. (total: 49,489 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KME82_RS09145: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

KME82_RS09150: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

KME82_RS09155: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

KME82_RS09160: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Hydrolases: hydrolase
KME82_RS09125: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: synthase
KME82_RS09165: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

Translocases: permease
KME82_RS09130: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000999.4 |  |  | 1.27 | NRPS, PKS | heat-stable antifungal factor | Lysobacter enzymogenes
BGC0002365.2 |  |  | 0.75 | PKS, other (other) | 10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2 | Streptomyces sp.
BGC0001043.4 |  |  | 0.75 | NRPS, PKS | SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001833.4 |  |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001273.3 |  |  | 0.67 | PKS | asperlactone | Aspergillus ochraceus
BGC0001132.4 |  |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  | 0.65 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001244.3 |  |  | 0.65 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0002286.3 |  |  | 0.65 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000999.4 |  | 0.86 | NRPS, PKS | heat-stable antifungal factor | Lysobacter enzymogenes
BGC0002365.2 |  | 0.70 | PKS, other (other) | 10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2 | Streptomyces sp.
BGC0001043.4 |  | 0.70 | NRPS, PKS | SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001273.3 |  | 0.66 | PKS | asperlactone | Aspergillus ochraceus
BGC0001132.4 |  | 0.66 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001244.3 |  | 0.66 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.43 out of 24.78
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72
Confidence: medium
Additional weak hits (21):
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.07 out of 20.97
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.57 out of 29.38
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.82 out of 21.55
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.12 out of 27.78
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.65 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.26 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.28 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.21 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.28 out of 28.14
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.34 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.45 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.96 out of 27.78
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.64 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.86 out of 31.73
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.70 out of 28.19
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.04 out of 20.01
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.26 out of 27.18
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.91 out of 28.19
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.82 out of 32.93
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.10 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 2180197 - 2229686:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk - Orn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KME82_RS09165: pk - Orn
Search NORINE for peptide: strict or relaxed
PKS_AT (579..875): pk
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%
  Methylmalonyl-CoA: 62.5%
  CE-Malonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:
  Methoxymalonyl-CoA: 116.4
  Methylmalonyl-CoA: 115.9
  Malonyl-CoA: 106.7
  Ethylmalonyl-CoA: 98.5
  Isobutyryl-CoA: 88.4
  2-Methylbutyryl-CoA: 71.5
  Propionyl-CoA: 69.8
  trans-1,2-CPDA: 57.3
  Acetyl-CoA: 57.1
  Benzoyl-CoA: 54.9
  3-Methylbutyryl-CoA: 41.7
  fatty_acid: 38.4
  inactive: 36.2
  CHC-CoA: 35.9

AMP-binding (2335..2745): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AGWAFDVFAGDREFVVGSDINSYGLSEATIDSTY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
NtrC | Nitrogen regulatory protein C

NZ_CP076103.1 - Region 5 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,513,316 - 2,536,054 nt. (total: 22,739 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KME82_RS10650: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthase
KME82_RS10585: Pseudouridine synthase

smcogs
  SMCOG1154: Pseudouridine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.56 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000551.5 |  | 0.52 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000513.3 |  | 0.49 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002111.3 |  | 0.48 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002698.2 |  | 0.44 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000546.3 |  | 0.44 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0002699.2 |  | 0.43 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000894.4 |  | 0.42 | other (other) | citrinin | Monascus aurantiacus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.56 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0000551.5 |  | 0.52 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000513.3 |  | 0.49 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002111.3 |  | 0.48 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002698.2 |  | 0.44 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000546.3 |  | 0.44 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0002699.2 |  | 0.43 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000894.4 |  | 0.42 | other (other) | citrinin | Monascus aurantiacus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KME82_RS10620

KME82_RS10615
Leader:
MNRILNLQKLAVSADPSDGAAAD
Core:
S T S S F A G C N C S T S S N G G C L C S G E V T I A V
Core with dehydrations:
Dha Dhb Dha Dha F A G Cys N Cys Dha Dhb Dha Dha N G G Cys L Cys Dha G E V Dhb I A V

#### antiSMASH-DB 4.0 matches for KME82_RS10615

100.0%
NZ_CP011130.1 and 4 others:
NZ_CP023465.1 Lanthipeptides: CNO08_RS25790_lanthipeptide NZ_CP076103.1 Lanthipeptides: KME82_RS10615_lanthipeptide NZ_CP094357.1 Lanthipeptides: IEQ11_RS10290_lanthipeptide NZ_KQ061217.1 Lanthipeptides: WN54_RS27350_lanthipeptide
Lanthipeptides: LC55x_RS27745_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L C S G E V T I A V
28
S T S S F A G C N C S T S S N G G C L C S G E V T I A V
1
S T S S F A G C N C S T S S N G G C L C S G E V T I A V
28
62.1%
NZ_CP093340.1:
Lanthipeptides: MNO14_RS13850_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L C S G E V T I A V
28
S T S S+A G C C S T+S N G C S +V I A+
3
S T S S Y A G C T C S T A S N T G C-G S S D V I I A L
29
50.0%
NZ_CP029843.1 and 1 other:
NZ_CP029843.1 Lanthipeptides: C9I47_RS17755_lanthipeptide
Lanthipeptides: C9I47_RS17755_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L C S G E V T I A V
28
S T S S G C C S T S C G+ I A V
4
S T S S N N G C A C S T E S A A V C F-M G D E F I A V
30
with 9 more sequence matches
46.4%
NZ_LMDB01000009.1:
Lanthipeptides: ASD07_RS30720_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L C S G E V
24
S T S S G C C S T+S C E V
1
S T S S G N G C A C S T A S A A L C F M G D E V
24
36.4%
NZ_CP072597.1 and 1 other:
NZ_CP072597.1 Lanthipeptides: J5226_RS06060_lanthipeptide
Lanthipeptides: J5226_RS06060_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L
19
S T S S G C C S T S G C
7
S T S S G N G C A C S T K S A G L C Y
25
35.7%
NZ_CP029843.1 and 1 other:
NZ_CP029843.1 Lanthipeptides: C9I47_RS17760_lanthipeptide
Lanthipeptides: C9I47_RS17760_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L C S G
22
+T S S C+C S +S C L G
1
T T S S N N S C D C S A T S V N S C L I D G
22
35.7%
NZ_CP054919.1 and 1 other:
NZ_JAGIYX010000006.1 Lanthipeptides: J5Y04_RS12150_lanthipeptide
Lanthipeptides: HUT16_RS18950_lanthipeptide
1
S T S S F A G C N C S T S S N G G C L C
20
S T S S + N C T S+ L C
7
S T S S L S V L N C G T S T V S T L L C
26
35.7%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_201135_201245_lanthipeptide
Lanthipeptides: allorf_201135_201245_lanthipeptide
1
S T S S F A G C N C S T S S N G G-C L C S G E V T I
26
S S+ C + + G G C L S G+ I
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
28.6%
NZ_CP110813.1:
Lanthipeptides: BV903_RS23035_lanthipeptide
11
S T S S N G G C L C
20
S S N G G C L C
8
S C S Y N G G C L C
17
25.0%
NC_019751.1:
Lassopeptides: CAL6303_RS30220_lassopeptide
15
N G G C L C S G E V T I
26
N G G L C G T+
2
N G G Y L C D G N S T L
13
19.4%
NZ_AP018365.1:
Lanthipeptides: allorf_0038677_0038835_lanthipeptide
8
C N C S T S S N G G C L C S G E
23
C S+ G G C+G
12
C R V P V S A T G G H R C A G R
27
14.3%
NC_012489.1:
Lanthipeptides: allorf_4594448_4594576_lanthipeptide
5
F A G C N C S T S S N G G C
18
+ G C + +G G C
6
Y L G C R P P S P E H G G C
19

#### MIBiG 4.0 matches for KME82_RS10615

11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
6
A G C N C S
11
A C+C S
24
A T C H C S
29

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 23.06 out of 26.12
Confidence: medium
Additional weak hits (2):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.94 out of 29.25
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.32 out of 26.12
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KME82_RS10615 - Class III
  Cleavage pHMM score: 4.10
  RODEO score: 0
  Monoisotopic mass: 2463.1 Da
  Molecular weight: 2464.7 Da
  Number of bridges: 4
  Additional modifications: Lac
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2482.7 Da N = 1
    2500.7 Da N = 2
    2518.7 Da N = 3
    2536.8 Da N = 4
    2554.8 Da N = 5
    2572.8 Da N = 6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LuxO | Repressor of luminescence
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP076103.1 - Region 6 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,081,970 - 3,185,537 nt. (total: 103,568 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
KME82_RS13015: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KME82_RS13065: Dioxygenase TauD/TfdA

smcogs
  SMCOG1046: Dioxygenase TauD/TfdA

KME82_RS13115: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KME82_RS13175: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

Transferases: kinase
KME82_RS13035: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: hydrolase
KME82_RS13130: isochorismatase

smcogs
  SMCOG1027: isochorismatase

KME82_RS13150: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Isomerases: isomerase
KME82_RS13140: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
KME82_RS13070: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KME82_RS13075: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KME82_RS13125: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KME82_RS13135: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRP-metallophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000343.5 |  |  | 0.88 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0002135.2 |  |  | 0.79 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  |  | 0.77 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  |  | 0.76 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001133.4 |  |  | 0.74 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000343.5 |  | 0.75 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001758.4 |  | 0.74 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002071.2 |  | 0.73 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027
BGC0001135.5 |  | 0.72 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001133.4 |  | 0.72 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.73 out of 18.46
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.48 out of 29.72
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.84 out of 26.85
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.95 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.63 out of 28.19
Confidence: medium
Additional weak hits (16):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.02 out of 30.22
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.84 out of 21.84
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.85 out of 18.57
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.44 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.16 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.06 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.40 out of 21.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.96 out of 28.14
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.51 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.87 out of 32.74
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.00 out of 29.25
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.70 out of 26.33
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.57 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 3081969 - 3185537:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ser - D-Asn - Asn - Gly - Pro - Leu - D-Thr) + (Asn - D-X) + (D-Orn - NMe-Val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KME82_RS13070: Ser - Asn - Asn - Gly - Pro - Leu - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (459..862): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFVCSGEHNLYGPTEAAIDVTA
  Nearest Stachelhaus code(s):
    Ser DVWHVSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1514..1918): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWSLFDGSVTVGKLILGGEINEYGPTEATVGCCT
  Nearest Stachelhaus code(s):
    Asn DGTKLGEVGK (94% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (3051..3461): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YFVSFDGSVTLGKLILGGEINEFGPTEATVGCSI
  Nearest Stachelhaus code(s):
    Asn DGTKLGEVGK (79% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (4122..4520): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAGLELQALCGGEWNMYGPTETTVWSLL
  Nearest Stachelhaus code(s):
    Gly DILQLGMVWK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (5175..5602): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHTFDVSAQESYAVQAGEHNHYGPSETHVVTAH
  Nearest Stachelhaus code(s):
    Pro DVQYVAHVVK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (6254..6668): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAQAFDAATMEMLIVVGGERNAYGPTEASICVTI
  Nearest Stachelhaus code(s):
    Leu DAMLVGAICK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (7316..7725): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LTAHFDFSVWEGNQVFGGEVNMYGITEVTVHASF
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

KME82_RS13075: Asn - X
Search NORINE for peptide: strict or relaxed
AMP-binding (463..874): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YFALFDGSVTLGKLLLGGEVNEFGPTEATVGCST
  Nearest Stachelhaus code(s):
    Asn DGTKLGEVGK (85% 8Å match)
    OH-Asn or Asn DGTKLGEVGK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1539..1946): X
nrpys: OH-Asn, Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWSLFDGSVTVGKLLLGGEINEYGPTEATVGCCV
  Nearest Stachelhaus code(s):
    OH-Asn or Asn DGTKLGEVGK (97% 8Å match)
    Asn DGTKLGEVGK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

KME82_RS13080: Orn - Val
Search NORINE for peptide: strict or relaxed
AMP-binding (1239..1652): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHHAFDTSIDAWDIMLGGEYNLYGPTECTVDACF
  Nearest Stachelhaus code(s):
    Orn DTEDMGLVDK (94% 8Å match)
    Lys DTDDMGYVDK (76% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (2775..3174): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FDRSFDASTYEVWLWAGGDVNGYGPTETTTFALS
  Nearest Stachelhaus code(s):
    Val DAYWWGGTFK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

KME82_RS13135: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (42..446): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SASLFPMSSPGGALQIGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PMPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
NtrC | Nitrogen regulatory protein C
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_CP076103.1 - Region 7 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,680,815 - 3,721,807 nt. (total: 40,993 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
KME82_RS15335: dioxygenase, TauD/TfdA

smcogs
  SMCOG1121: dioxygenase, TauD/TfdA

KME82_RS15360: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

KME82_RS15415: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: dehalogenase
KME82_RS15385: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Ligases: synthase
KME82_RS15330: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

KME82_RS15340: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001238.3 |  | 0.47 | other (other) | biotin | Aspergillus nidulans
BGC0001239.3 |  | 0.46 | other (other) | biotin | Aspergillus nidulans
BGC0001206.5 |  | 0.44 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0001633.3 |  | 0.43 | other (other) | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001302.5 |  | 0.42 | other (other) | lomofungin | Streptomyces lomondensis
BGC0002496.3 |  | 0.38 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0000218.5 |  | 0.38 | PKS | doxorubicin | Streptomyces peucetius
BGC0001726.4 |  | 0.38 | NRPS, PKS | pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F | Streptomyces pactum
BGC0000217.5 |  | 0.37 | PKS | daunorubicin | Streptomyces sp.
BGC0000666.5 |  | 0.37 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001238.3 |  | 0.47 | other (other) | biotin | Aspergillus nidulans
BGC0001239.3 |  | 0.46 | other (other) | biotin | Aspergillus nidulans
BGC0001206.5 |  | 0.44 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0001633.3 |  | 0.43 | other (other) | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001302.5 |  | 0.42 | other (other) | lomofungin | Streptomyces lomondensis
BGC0002496.3 |  | 0.38 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0000218.5 |  | 0.38 | PKS | doxorubicin | Streptomyces peucetius
BGC0001726.4 |  | 0.38 | NRPS, PKS | pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F | Streptomyces pactum
BGC0000217.5 |  | 0.37 | PKS | daunorubicin | Streptomyces sp.
BGC0000666.5 |  | 0.37 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.29 out of 20.97
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.83 out of 20.97
Confidence: medium
Additional weak hits (20):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.77 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.00 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.83 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.24 out of 29.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.87 out of 30.97
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.00 out of 28.14
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.81 out of 20.01
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.26 out of 32.93
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.57 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.30 out of 32.74
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.00 out of 18.57
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.75 out of 30.25
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.57 out of 33.14
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.73 out of 20.01
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.88 out of 20.01
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.49 out of 29.65
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.69 out of 35.63
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KME82_RS15350: X
AMP-binding (309..546): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TAGSFSQMAVETIGLYGGT----------VVASV
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A

NZ_CP076103.1 - Region 8 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,150,287 - 4,173,157 nt. (total: 22,871 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
KME82_RS17295: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.44 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.43 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000527.5 |  | 0.36 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002699.2 |  | 0.35 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000517.4 |  | 0.34 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000502.5 |  | 0.33 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0002330.2 |  | 0.32 | ribosomal | landornamide A | Kamptonema sp. PCC 6506
BGC0001407.5 |  | 0.32 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0001311.5 |  | 0.31 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.44 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.43 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000527.5 |  | 0.36 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002699.2 |  | 0.35 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000517.4 |  | 0.34 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000502.5 |  | 0.33 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0002330.2 |  | 0.32 | ribosomal | landornamide A | Kamptonema sp. PCC 6506
BGC0001407.5 |  | 0.32 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0001311.5 |  | 0.31 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KME82_RS17295

KME82_RS17290
Leader:
MPMNAEISQDVLNRLLSESIGS
Core:
P D L S D D K L V D L S S N L L S L S C V Y T S C H N C R E
Core with dehydrations:
P D L Dha D D K L V D L Dha Dha N L L Dha L Dha Cys V Y Dhb Dha Cys H N Cys R E

#### antiSMASH-DB 4.0 matches for KME82_RS17290

100.0%
NZ_CP023465.1 and 4 others:
NZ_CP076103.1 Lanthipeptides: KME82_RS17290_lanthipeptide NZ_CP094357.1 Lanthipeptides: IEQ11_RS16865_lanthipeptide NZ_KQ061217.1 Lanthipeptides: WN54_RS27465_lanthipeptide NZ_LMHM01000013.1 Lanthipeptides: ASD86_RS26755_lanthipeptide
Lanthipeptides: CNO08_RS26020_lanthipeptide
1
P D L S D D K L V D L S S N L L S L S C V Y T S C H N C R E
30
P D L S D D K L V D L S S N L L S L S C V Y T S C H N C R E
1
P D L S D D K L V D L S S N L L S L S C V Y T S C H N C R E
30
53.3%
NZ_JALBFU010000008.1:
Lanthipeptides: MD221_RS13840_lanthipeptide
1
P D L S D D K L V D L S S N L L S L S C V Y T S C H N C
28
P D L S D D K L V D S N+ + + Y S C +C
1
P D L S D D K L V D K G S N M A T A N T C Y R S C L H C
28
21.9%
NZ_CP033919.1:
Lanthipeptides: EG347_RS22885_lanthipeptide
17
S L S C V Y T S C H
26
S L S C+ T S C+
19
S L S C I A T S C N
28
with 3 more sequence matches
20.0%
NZ_CP011130.1 and 1 other:
NZ_CP094357.1 Lanthipeptides: allorf_0706777_0706872_lanthipeptide
Lanthipeptides: allorf_0740171_0740266_lanthipeptide
19
S C V Y T S C H N C
28
C V T C H C
3
G C V L T G C H G C
12
16.0%
NZ_FOOL01000020.1:
Lanthipeptides: allorf_02901_03086_lanthipeptide
15
L L S L S C V Y T S C H N C R
29
L L S+S S C N C+
14
L L S V S A P L E S C T N C K
28
12.1%
NZ_CP011130.1:
Lanthipeptides: allorf_0736140_0736358_lanthipeptide
1
P D L S D D K L V D L S S N L L S L S C V Y T S C H N C
28
P D S V D L ++++ + + C
3
P D S S M R S A V D L R R D V I A Q R A L R P A S E K C
30
allorf_4152283_4152408
Leader:
MGLAAVVETTPQPRDHTVAYR
Core:
S R H P R C A C G I A R R T R R D A R S
Core with dehydrations:
Dha R H P R Cys A Cys G I A R R Dhb R R D A R Dha

#### antiSMASH-DB 4.0 matches for allorf_4152283_4152408

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4152283_4152408_lanthipeptide
1
S R H P R C A C G I A R R T R R D A R S
20
S R H P R C A C G I A R R T R R D A R S
1
S R H P R C A C G I A R R T R R D A R S
20
40.0%
NZ_CP013219.1:
Lanthipeptides: allorf_0169157_0169261_lanthipeptide
4
P R C A C G I A R R T R R D A R
19
P C G I A R R R
5
P A C P G G I A R P F R T P P R
20
18.4%
NC_017765.1 and 1 other:
NZ_KQ948355.1 Lanthipeptides: AQJ11_RS50945_lanthipeptide
Lanthipeptides: SHJG_RS52475_lanthipeptide
4
P R C A C G I A R R T R R D A R
19
P C A G I A R R R
34
P A C A G G I A R P F R T P P R
49
with 1 more sequence matches
18.2%
NZ_LMHM01000017.1:
Lanthipeptides: allorf_219069_219302_lanthipeptide
4
P R C A C G I A R R T R
15
P R A G I A R R +
23
P R I A S G I A R R P Q
34
allorf_4155031_4155183
Leader:
MVGVCNAGRYRFDERPGA
Core:
C V T S A N D P R R P G H R P R H R A M A W R D G A T R P R L T
Core with dehydrations:
Cys V Dhb Dha A N D P R R P G H R P R H R A M A W R D G A Dhb R P R L Dhb

#### antiSMASH-DB 4.0 matches for allorf_4155031_4155183

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4155031_4155183_lanthipeptide
1
C V T S A N D P R R P G H R P R H R A M A W R D G A T R P R L T
32
C V T S A N D P R R P G H R P R H R A M A W R D G A T R P R L T
1
C V T S A N D P R R P G H R P R H R A M A W R D G A T R P R L T
32
27.0%
NZ_BNCF01000005.1:
Lanthipeptides: allorf_096655_096867_lanthipeptide
7
D P R R P G H R P R H R A M A W R D G A T R P R L
31
D R+P R P +A R T R L
1
D R R K P A S R P S S D V V A R R T C V T V S R L
25
22.9%
NZ_CP015225.1:
Lanthipeptides: allorf_5856729_5856932_lanthipeptide
15
P R H R A M A W R D G A T
27
P R H R +A W D A
12
P R H R V V A W L D C A V
24
with 4 more sequence matches
18.8%
NZ_BCBX01000066.1 and 1 other:
NZ_BCBX01000066.1 Lanthipeptides: AP234_RS33370_lanthipeptide
Lanthipeptides: AP234_RS33370_lanthipeptide
1
C V T S A N D P
8
C T S+N D P
20
C A T S S N D P
27
16.9%
NZ_CP041244.1:
Lanthipeptides: allorf_9037809_9038009_lanthipeptide
11
P G H R P R H R A M A W R D G A T R P
29
P G H R P R H G R P
33
P G H R P R H G I G Q A N A G P L R P
51
16.3%
NZ_BBXG01000024.1:
Lanthipeptides: allorf_101043_101213_lanthipeptide
6
N D P R R P G H R P R H R
18
N P R R R P H R
10
N S P R R N Q R R P A H R
22
13.1%
NZ_CP110813.1:
Lanthipeptides: BV903_RS23420_lanthipeptide
6
N D P R R P G H R P R H R A M A W R
23
+ P R P G+ + R A W R
20
D H P R D P G Y Y Y Q C R G G A W R
37
allorf_4159188_4159313
Leader:
MWTPPEHLLDYPYA
Core:
H R Q A G R V A T S P P M G G R S S D A H G D C P L P
Core with dehydrations:
H R Q A G R V A Dhb Dha P P M G G R Dha Dha D A H G D Cys P L P

#### antiSMASH-DB 4.0 matches for allorf_4159188_4159313

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4159188_4159313_lanthipeptide
1
H R Q A G R V A T S P P M G G R S S D A H G D C P L P
27
H R Q A G R V A T S P P M G G R S S D A H G D C P L P
1
H R Q A G R V A T S P P M G G R S S D A H G D C P L P
27
22.5%
NZ_BNBV01000031.1:
Lanthipeptides: allorf_32355_32513_lanthipeptide
7
V A T S P P M G G R S S D A H G D C
24
V A T S + G R+ A G C
3
V A T S G R V A G R T G V A R G G C
20
18.2%
NZ_CP021646.1 and 1 other:
NZ_CP031759.1 Lanthipeptides: D0N37_RS18595_lanthipeptide
Lanthipeptides: B1L02_RS18305_lanthipeptide
5
G R V A T S P P M G G R S S D A H G D C
24
G V + P G +D +G D C
9
G D V Q A N S P A G S I F T D R Y G D C
28
with 3 more sequence matches
18.2%
NZ_CP024625.1 and 3 others:
NZ_CP047238.1 Lanthipeptides: GSF04_RS22995_lanthipeptide NZ_CP068023.1 Lanthipeptides: JJQ94_RS23815_lanthipeptide NZ_CP081860.1 Lanthipeptides: K5642_RS18070_lanthipeptide
Lanthipeptides: CTT31_RS17865_lanthipeptide
5
G R V A T S P P M G G R S S D A H G D C
24
G V + P G +D +G D C
9
G D V Q A N S P A G S L F T D R Y G D C
28
12.3%
NZ_CP098485.1 and 1 other:
NZ_CP098485.1 Lanthipeptides: allorf_8118363_8118593_lanthipeptide
Lanthipeptides: allorf_8118363_8118593_lanthipeptide
1
H R Q A G R V A T S P
11
H R Q V A T+P
45
H R Q L S Y V A T A P
55
11.8%
NZ_CP020040.1:
Lanthipeptides: allorf_284366_284596_lanthipeptide
10
S P P M G G R S S D A H G
22
+P P+G R + H G
39
A P P L G C R R A T L H G
51
allorf_4159223_4159375
Leader:
MSRRVLARLPTPRYVTVCARHYGRGQSPCA
Core:
S L D L P P I G G E V A T R P A C R W A
Core with dehydrations:
Dha L D L P P I G G E V A Dhb R P A Cys R W A

#### antiSMASH-DB 4.0 matches for allorf_4159223_4159375

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4159223_4159375_lanthipeptide
1
S L D L P P I G G E V A T R P A C R W A
20
S L D L P P I G G E V A T R P A C R W A
1
S L D L P P I G G E V A T R P A C R W A
20
30.4%
NZ_FOAZ01000010.1:
Lanthipeptides: allorf_093307_093468_lanthipeptide
5
P P I G G E V A T R P A C R
18
P G +V R P C R
3
P R G G A K V G A R P G C R
16
25.9%
NZ_CP022203.1:
Lanthipeptides: allorf_3356932_3357072_lanthipeptide
9
G E V A T R P A C R
18
G E A P A C R
2
G E R A A H P A C R
11
with 6 more sequence matches
16.7%
NZ_JAGFWR010000004.1:
Lanthipeptides: allorf_396312_396491_lanthipeptide
11
V A T R P A C R W
19
R P C R W
6
T G R R P G C R W
14
15.6%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12140_lanthipeptide
Lanthipeptides: IV75_RS14640_lanthipeptide
7
I G G E V A T R P A C R W A
20
I G E T P A C ++
3
I N G E F T T S P A C V Y S
16
14.3%
NZ_JAFLVY010000007.1:
Lanthipeptides: JZO73_RS03905_lanthipeptide
7
I G G E V A T R P A C R W A
20
+ G E T P A C ++
3
V N G E F T T S P A C L Y S
16
13.3%
NZ_CP102973.1 and 1 other:
NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14440_lanthipeptide
Lanthipeptides: NW963_RS14080_lanthipeptide
7
I G G E V A T R P A C R W A
20
+ G E T P A C ++
3
M N G E F T T S P A C V Y S
16
12.2%
NZ_JADNGS010000002.1:
Lanthipeptides: I2D92_RS06835_lanthipeptide
7
I G G E V A T R P A C R W
19
+ G E T P A C +
3
V S G E F T T S P A C V Y
15
12.2%
NZ_QICS01000003.1:
Lanthipeptides: C8E03_RS08695_lanthipeptide
7
I G G E V A T R P A C
17
+G E T P A C
3
V G A E F T T S P A C
13
allorf_4159822_4159995
Leader:
MMPRADARCQRDKNARSIVSRIRTDARNAA
Core:
S F T V Q H I A P P R H A N P P A S S R T V R T T H C
Core with dehydrations:
Dha F Dhb V Q H I A P P R H A N P P A Dha Dha R Dhb V R Dhb Dhb H Cys

#### antiSMASH-DB 4.0 matches for allorf_4159822_4159995

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4159822_4159995_lanthipeptide
1
S F T V Q H I A P P R H A N P P A S S R T V R T T H C
27
S F T V Q H I A P P R H A N P P A S S R T V R T T H C
1
S F T V Q H I A P P R H A N P P A S S R T V R T T H C
27
92.6%
NZ_CP094357.1:
Lanthipeptides: allorf_4140917_4141090_lanthipeptide
1
S F T V Q H I A P P R H A N P P A S S R T V R T T H C
27
S T V Q H I A P R H A N P P A S S R T V R T T H C
1
S L T V Q H I A S P R H A N P P A S S R T V R T T H C
27
29.6%
NZ_BNBJ01000003.1 and 1 other:
NZ_JAMFLF010000021.1 Lanthipeptides: allorf_030895_031062_lanthipeptide
Lanthipeptides: allorf_023401_023568_lanthipeptide
11
R H A N P P A S S R T V R
23
R N P P S R T+R
10
R P W N P P R S C R T L R
22
with 1 more sequence matches
25.9%
NZ_CP077072.1:
Lanthipeptides: allorf_2549811_2549951_lanthipeptide
8
A P P R H A N P
15
A P P R H A P
6
A P P R H A E P
13
allorf_4165264_4165497
Leader:
MCRTSHFISQDVSVLLQKSNVNGA
Core:
S G E G K P H S S W E I S L S V G V A L F R S G V W R R F A E R V G L P W T R I C S S T R A R G H T A C L
Core with dehydrations:
Dha G E G K P H Dha Dha W E I Dha L Dha V G V A L F R Dha G V W R R F A E R V G L P W Dhb R I Cys Dha Dha Dhb R A R G H Dhb A Cys L

#### antiSMASH-DB 4.0 matches for allorf_4165264_4165497

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4165264_4165497_lanthipeptide
1
S G E G K P H S S W E I S L S V G V A L F R S G V W R R F A E R V G L P W T R I C S S T R A R G H T A C L
53
S G E G K P H S S W E I S L S V G V A L F R S G V W R R F A E R V G L P W T R I C S S T R A R G H T A C L
1
S G E G K P H S S W E I S L S V G V A L F R S G V W R R F A E R V G L P W T R I C S S T R A R G H T A C L
53
15.1%
NZ_JABBWU010000001.1:
Lanthipeptides: allorf_0525516_0525686_lanthipeptide
2
G E G K P H S S W E I S L S V G
17
G G+P H S S I G
12
G A G R P H S S A A I C A K Q G
27
13.2%
NZ_MSRJ01000005.1:
Lanthipeptides: allorf_220341_220451_lanthipeptide
33
V G L P W T R I C S
42
V P W R I C S
6
V R N P W E R I C S
15

#### MIBiG 4.0 matches for allorf_4165264_4165497

5.7%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
36
P W T R I C S
42
P+T +C
9
P F T F V C D
15
allorf_4165970_4166110
Leader:
MHAVRHRDMDVPCG
Core:
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
Core with dehydrations:
A Cys L R K L Cys Dhb Cys G P L I Q R K A F F F G Y L Dha F V A L D K R K

#### antiSMASH-DB 4.0 matches for allorf_4165970_4166110

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4165970_4166110_lanthipeptide
1
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
1
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
84.4%
NZ_CP011130.1:
Lanthipeptides: allorf_4096696_4096836_lanthipeptide
1
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
A C R K T G P L I Q R K A F F F G Y L S F V A D K R K
1
A C P R K H R T R G P L I Q R K A F F F G Y L S F V A F D K R K
32
81.2%
NZ_KQ061217.1:
Lanthipeptides: allorf_2984229_2984378_lanthipeptide
1
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
A C L R+ T G P L I K A F F F G Y L S F V A L D K R K
1
A C L R Q H R T R G P L I H N K A F F F G Y L S F V A L D K R K
32
with 6 more sequence matches
71.9%
NZ_CP023465.1:
Lanthipeptides: allorf_4138164_4138391_lanthipeptide
1
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
A C R + G L I +K A F F F G Y L S F V A L D K R K
1
A C P R L H R S R G L L I H K K A F F F G Y L S F V A L D K R K
32
50.0%
NZ_CP011129.1:
Lanthipeptides: allorf_3545419_3545634_lanthipeptide
2
C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
L R +C G P L I Q R K A F F F G Y L S F V A D K R K
20
S L R M H R S C G P L I Q R K A F F F G Y L S F V A Y D K R K
50
46.0%
NZ_CP011129.1:
Lanthipeptides: allorf_3545977_3546195_lanthipeptide
2
C L R K L C T C G P L I Q R K A F F F G Y L S F V A L D K R K
32
L R+ +C G +I Q R K A F F F G Y L S F V A D K R K
20
S L R R H R S C G L V I Q R K A F F F G Y L S F V A Y D K R K
50
38.2%
NZ_CP076103.1:
Lanthipeptides: allorf_5473643_5473795_lanthipeptide
2
C L R K L C T C G P L I Q R K A F F F G Y L
23
C R K T G I +K F F F G Y L
1
C P R K R R T R G H S I H K K T F F F G Y L
22
29.8%
NZ_KQ061217.1:
Lanthipeptides: allorf_2982148_2982333_lanthipeptide
1
A C L R K L C T C G P L I Q R K A F F F G Y L S F V A L
28
A C R +C L I F F F G Y L+F V +
1
A C P R L H R S C E Q L I N S G E F F F G Y L A F V V I
28
18.8%
NZ_LMSL01000013.1:
Lanthipeptides: allorf_11540_11626_lanthipeptide
5
K L C T C G P L I Q R K
16
+L C C G P R
7
R L C N C G P A G G R H
18
allorf_4170363_4170485
Leader:
MHYPDFGGPRPPQNGPILAGSAAS
Core:
A W L C S S T G H A K P W P A R
Core with dehydrations:
A W L Cys Dha Dha Dhb G H A K P W P A R

#### antiSMASH-DB 4.0 matches for allorf_4170363_4170485

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4170363_4170485_lanthipeptide
1
A W L C S S T G H A K P W P A R
16
A W L C S S T G H A K P W P A R
1
A W L C S S T G H A K P W P A R
16
87.5%
NZ_CP023465.1:
Lanthipeptides: allorf_4142857_4142979_lanthipeptide
1
A W L C S S T G H A K P W P A R
16
A W L C S T G H A K P W A R
1
A W L C S C T G H A K P W S A R
16
81.2%
NZ_CP011130.1 and 2 others:
NZ_CP094357.1 Lanthipeptides: allorf_4151594_4151716_lanthipeptide NZ_KQ061217.1 Lanthipeptides: allorf_2988586_2988708_lanthipeptide
Lanthipeptides: allorf_4101067_4101189_lanthipeptide
1
A W L C S S T G H A K P W P A R
16
A W L C S T G H A+P W A R
1
A W L C S C T G H A E P W S A R
16
with 3 more sequence matches
31.2%
NZ_CP096021.1:
Lanthipeptides: allorf_381222_381323_lanthipeptide
1
A W L C S S T G H
9
W L C S+ H
2
V W L C S N M H H
10
20.7%
NZ_LMSL01000013.1:
Lanthipeptides: allorf_11272_11457_lanthipeptide
1
A W L C S S T G H A
10
W L C S T G
9
G W L C S Y T G E C
18
12.0%
NZ_WWGT01000021.1 and 1 other:
NZ_WWGT01000021.1 Lanthipeptides: allorf_033513_033707_lanthipeptide
Lanthipeptides: allorf_033513_033707_lanthipeptide
4
C S S T G H A K P W P A R
16
C+++ A+P P A R
36
C T A S R A A R P R P A R
48
allorf_4172863_4173060
Leader:
MDRRAWRKRLLRGTRVAAVVSRSRLAPLLQWAIRITAAAA
Core:
A L I Q A T D A R L L A E L F K R Y A L P R C S L
Core with dehydrations:
A L I Q A Dhb D A R L L A E L F K R Y A L P R Cys Dha L

#### antiSMASH-DB 4.0 matches for allorf_4172863_4173060

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_4172863_4173060_lanthipeptide
1
A L I Q A T D A R L L A E L F K R Y A L P R C S L
25
A L I Q A T D A R L L A E L F K R Y A L P R C S L
1
A L I Q A T D A R L L A E L F K R Y A L P R C S L
25
20.0%
NZ_NVEA01000022.1:
Lanthipeptides: allorf_48557_48673_lanthipeptide
14
L F K R Y A L P R C
23
L F+ Y P C
1
L F Q E Y V T P V C
10

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.94 out of 20.01
Confidence: medium
Additional weak hits (15):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.35 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.22 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.42 out of 18.57
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.25 out of 32.74
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.99 out of 30.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.62 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.29 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.50 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.76 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.48 out of 26.06
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.12 out of 21.84
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.77 out of 33.14
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.23 out of 20.01
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KME82_RS17290 - Class II
  Cleavage pHMM score: -4.40
  RODEO score: 0
  Monoisotopic mass: 3199.5 Da
  Molecular weight: 3201.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3219.6 Da N = 1
    3237.6 Da N = 2
    3255.6 Da N = 3
    3273.6 Da N = 4
allorf_4152283_4152408 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 2270.2 Da
  Molecular weight: 2271.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2289.6 Da N = 1
allorf_4155031_4155183 - Class II
  Cleavage pHMM score: -5.40
  RODEO score: 0
  Monoisotopic mass: 3621.9 Da
  Molecular weight: 3624.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3642.1 Da N = 1
    3660.1 Da N = 2
    3678.1 Da N = 3
allorf_4159188_4159313 - Class II
  Cleavage pHMM score: -5.80
  RODEO score: 0
  Monoisotopic mass: 2684.3 Da
  Molecular weight: 2685.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2704.0 Da N = 1
    2722.0 Da N = 2
    2740.0 Da N = 3
allorf_4159223_4159375 - Class II
  Cleavage pHMM score: -7.20
  RODEO score: 0
  Monoisotopic mass: 2072.1 Da
  Molecular weight: 2073.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2091.4 Da N = 1
allorf_4159822_4159995 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 2841.5 Da
  Molecular weight: 2843.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2861.2 Da N = 1
    2879.2 Da N = 2
    2897.2 Da N = 3
    2915.2 Da N = 4
    2933.3 Da N = 5
    2951.3 Da N = 6
allorf_4165264_4165497 - Class II
  Cleavage pHMM score: -1.90
  RODEO score: 0
  Monoisotopic mass: 5655.0 Da
  Molecular weight: 5658.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5676.4 Da N = 1
    5694.4 Da N = 2
    5712.5 Da N = 3
    5730.5 Da N = 4
    5748.5 Da N = 5
    5766.5 Da N = 6
    5784.5 Da N = 7
    5802.6 Da N = 8
    5820.6 Da N = 9
allorf_4165970_4166110 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3656.0 Da
  Molecular weight: 3658.4 Da
  Number of bridges: 2
allorf_4170363_4170485 - Class II
  Cleavage pHMM score: -4.30
  RODEO score: 0
  Monoisotopic mass: 1712.9 Da
  Molecular weight: 1713.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1732.0 Da N = 1
    1750.0 Da N = 2
allorf_4172863_4173060 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 2795.6 Da
  Molecular weight: 2797.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2815.3 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
MexT | Global virulence regulator

NZ_CP076103.1 - Region 9 - redox-cofactor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,428,801 - 4,451,018 nt. (total: 22,218 nt) Show pHMM detection rules used
redox-cofactor: (cds(PF04055 and (TIGR04085 or SPASM)) and (TIGR02111 or TIGR03966) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
KME82_RS18405: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: amidase back translocase
KME82_RS18415: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

KME82_RS18460: amidase

smcogs
  SMCOG1105: amidase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | redox-cofactor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000936.5 |  | 0.41 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0002561.3 |  | 0.39 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001444.5 |  | 0.37 | other (shikimate-derived) | caboxamycin | Streptomyces sp. NTK 937
BGC0002015.4 |  | 0.36 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0001080.5 |  | 0.36 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001221.5 |  | 0.36 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0000934.4 |  | 0.34 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0002492.3 |  | 0.34 | NRPS | myxochelin B, myxochelin A | Myxococcus xanthus DK 1622
BGC0002324.3 |  | 0.33 | NRPS, PKS | myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A | Archangium violaceum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000936.5 |  | 0.41 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1
BGC0002561.3 |  | 0.39 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001444.5 |  | 0.37 | other (shikimate-derived) | caboxamycin | Streptomyces sp. NTK 937
BGC0002015.4 |  | 0.36 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0001080.5 |  | 0.36 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0001221.5 |  | 0.36 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0000934.4 |  | 0.34 | other (phenazine) | 5-acetyl-5,10-dihydrophenazine-1-carboxylic acid, 5-(2-hydroxyacetyl)-5,10-dihydrophenazine-1-carboxylic acid, endophenazine A1, endophenazine F, endophenazine G | Kitasatospora sp. HKI 714
BGC0002492.3 |  | 0.34 | NRPS | myxochelin B, myxochelin A | Myxococcus xanthus DK 1622
BGC0002324.3 |  | 0.33 | NRPS, PKS | myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A | Archangium violaceum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
Additional weak hits (11):
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.90 out of 18.57
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.77 out of 21.55
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.98 out of 27.78
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.54 out of 29.38
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.57 out of 30.98
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.75 out of 28.19
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.56 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.32 out of 29.65
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.60 out of 30.98
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.84 out of 28.19
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

redox-cofactor protocluster (4428800...4451018)
KME82_RS18445
  RRE type: PqqD_RRE
  Location: 3 - 92
  Score: 105.2
  RRE type: Stand_Alone_Lasso_RRE
  Location: 36 - 92
  Score: 33.9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP076103.1 - Region 10 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,077,931 - 5,089,202 nt. (total: 11,272 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002144.3 |  | 0.38 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0000571.3 |  | 0.36 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000501.3 |  | 0.36 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.36 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0002698.2 |  | 0.36 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002150.2 |  | 0.35 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.34 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001549.3 |  | 0.33 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000517.4 |  | 0.33 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001552.3 |  | 0.33 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002144.3 |  | 0.38 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0000571.3 |  | 0.36 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000501.3 |  | 0.36 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.36 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0002698.2 |  | 0.36 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002150.2 |  | 0.35 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.34 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001549.3 |  | 0.33 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000517.4 |  | 0.33 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001552.3 |  | 0.33 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
Additional weak hits (3):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 26.33
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.27 out of 29.51
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.57 out of 20.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP076103.1 - Region 11 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,143,024 - 5,154,295 nt. (total: 11,272 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000469.6 |  | 0.25 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0000604.4 |  | 0.20 | ribosomal | GE2270A | Nonomuraea sp. WU8817

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000469.6 |  | 0.25 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0000604.4 |  | 0.20 | ribosomal | GE2270A | Nonomuraea sp. WU8817

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.13 out of 18.57
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26
Confidence: medium
Additional weak hits (2):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.60 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.80 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ToxT | Regulator of MSHA biosynthesis

NZ_CP076103.1 - Region 12 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,463,847 - 5,486,711 nt. (total: 22,865 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
KME82_RS22800: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Lyases: cyclase
KME82_RS22810: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002704.2 |  | 0.46 | ribosomal | archalan β | Halorussus salinus
BGC0001576.3 |  | 0.46 | ribosomal | divamide A | Prochloron didemni
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.41 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001407.5 |  | 0.41 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000527.5 |  | 0.40 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001364.3 |  | 0.39 | ribosomal | cinnamycin B | Actinomadura atramentaria DSM 43919

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.4 |  | 0.49 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002704.2 |  | 0.46 | ribosomal | archalan β | Halorussus salinus
BGC0001576.3 |  | 0.46 | ribosomal | divamide A | Prochloron didemni
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.41 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001407.5 |  | 0.41 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000527.5 |  | 0.40 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001364.3 |  | 0.39 | ribosomal | cinnamycin B | Actinomadura atramentaria DSM 43919

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KME82_RS22810

allorf_5468547_5468636
Leader:
MRLSSGHDARAAA
Core:
V Q S P F L P R C T T T R C L R
Core with dehydrations:
V Q Dha P F L P R Cys Dhb Dhb Dhb R Cys L R

#### antiSMASH-DB 4.0 matches for allorf_5468547_5468636

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_5468547_5468636_lanthipeptide
1
V Q S P F L P R C T T T R C L R
16
V Q S P F L P R C T T T R C L R
1
V Q S P F L P R C T T T R C L R
16
37.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: allorf_17125_17301_lanthipeptide
Lanthipeptides: allorf_17125_17301_lanthipeptide
6
L P R C T T T R C L R
16
L P T T+C+R
5
L P M K T G T K C I R
15
15.0%
NZ_BMRY01000003.1 and 4 others:
NZ_CP084357.1 Lanthipeptides: allorf_8065442_8065603_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: allorf_198908_199069_lanthipeptide NZ_KZ819178.1 Lanthipeptides: allorf_4060176_4060337_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: allorf_787759_787920_lanthipeptide
Lanthipeptides: allorf_443305_443466_lanthipeptide
2
Q S P F L P R C T T T
12
++P F L P C T
24
R N P F L P E C P H T
34

#### MIBiG 4.0 matches for allorf_5468547_5468636

10.8%
BGC0001229.4 (SBI_06989)and 1 other:
BGC0002110.3 (QKV49894.1) Lanthipeptide: birimositide
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
C T T T R C
14
C T T+C
28
C P T T K C
33
allorf_5469493_5469603
Leader:
MQGRALRGG
Core:
C R S D R L T L A A S N H S G T W M H T E S V G A V R
Core with dehydrations:
Cys R Dha D R L Dhb L A A Dha N H Dha G Dhb W M H Dhb E Dha V G A V R

#### antiSMASH-DB 4.0 matches for allorf_5469493_5469603

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_5469493_5469603_lanthipeptide
1
C R S D R L T L A A S N H S G T W M H T E S V G A V R
27
C R S D R L T L A A S N H S G T W M H T E S V G A V R
1
C R S D R L T L A A S N H S G T W M H T E S V G A V R
27
25.0%
NZ_JADMQU010000019.1:
Lanthipeptides: I2G64_RS09215_lanthipeptide
1
C R S D R L T L A A S N H
13
C R R L+L + N H
15
C R H K R L S L I S L N H
27
22.2%
NZ_CP028940.1:
Lanthipeptides: allorf_0608251_0608346_lanthipeptide
9
A A S N H S G T W M H T E S V G A V
26
A N+S W+ +S A+
2
A V K N Y S E E W L V K Q S T C A I
19
allorf_5471305_5471397
Leader:
MSYLAHDGSVAAS
Core:
P M R P C L H R P A R T S G I Q T
Core with dehydrations:
P M R P Cys L H R P A R Dhb Dha G I Q Dhb

#### antiSMASH-DB 4.0 matches for allorf_5471305_5471397

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_5471305_5471397_lanthipeptide
1
P M R P C L H R P A R T S G I Q T
17
P M R P C L H R P A R T S G I Q T
1
P M R P C L H R P A R T S G I Q T
17
31.6%
NZ_CP023465.1:
Lanthipeptides: allorf_5420908_5421021_lanthipeptide
5
C L H R P A
10
C L H R P A
7
C L H R P A
12
19.2%
NZ_KB903814.1:
Lanthipeptides: allorf_845501_845632_lanthipeptide
2
M R P C L H R
8
+R P C H R
20
V R P C C H R
26
allorf_5473643_5473795
Leader:
MDVRRAPPGQDVPCGA
Core:
C P R K R R T R G H S I H K K T F F F G Y L L T E G N P D R I F S L
Core with dehydrations:
Cys P R K R R Dhb R G H Dha I H K K Dhb F F F G Y L L Dhb E G N P D R I F Dha L

#### antiSMASH-DB 4.0 matches for allorf_5473643_5473795

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_5473643_5473795_lanthipeptide
1
C P R K R R T R G H S I H K K T F F F G Y L L T E G N P D R I F S L
34
C P R K R R T R G H S I H K K T F F F G Y L L T E G N P D R I F S L
1
C P R K R R T R G H S I H K K T F F F G Y L L T E G N P D R I F S L
34
47.1%
NZ_CP011130.1:
Lanthipeptides: allorf_4096696_4096836_lanthipeptide
1
C P R K R R T R G H S I H K K T F F F G Y L
22
C P R K R T R G I +K F F F G Y L
2
C P R K H R T R G P L I Q R K A F F F G Y L
23
47.1%
NZ_CP023465.1:
Lanthipeptides: allorf_4138164_4138391_lanthipeptide
1
C P R K R R T R G H S I H K K T F F F G Y L
22
C P R R+R G I H K K F F F G Y L
2
C P R L H R S R G L L I H K K A F F F G Y L
23
with 6 more sequence matches
44.1%
NZ_KQ061217.1:
Lanthipeptides: allorf_2984229_2984378_lanthipeptide
1
C P R K R R T R G H S I H K K T F F F G Y L
22
C R+ R T R G I H K F F F G Y L
2
C L R Q H R T R G P L I H N K A F F F G Y L
23
38.2%
NZ_CP076103.1:
Lanthipeptides: allorf_4165970_4166110_lanthipeptide
1
C P R K R R T R G H S I H K K T F F F G Y L
22
C R K T G I +K F F F G Y L
2
C L R K L C T C G P L I Q R K A F F F G Y L
23
23.4%
NZ_KQ061217.1:
Lanthipeptides: allorf_2982148_2982333_lanthipeptide
1
C P R K R R T R G H S I H K K T F F F G Y L
22
C P R R+ I+ F F F G Y L
2
C P R L H R S C E Q L I N S G E F F F G Y L
23
22.0%
NZ_CP011129.1:
Lanthipeptides: allorf_3545419_3545634_lanthipeptide
3
R K R R T R G H S I H K K T F F F G Y L
22
R R+ G I +K F F F G Y L
22
R M H R S C G P L I Q R K A F F F G Y L
41
22.0%
NZ_CP011129.1:
Lanthipeptides: allorf_3545977_3546195_lanthipeptide
3
R K R R T R G H S I H K K T F F F G Y L
22
R+ R+ G I +K F F F G Y L
22
R R H R S C G L V I Q R K A F F F G Y L
41
20.5%
NZ_BMLN01000009.1:
Lanthipeptides: allorf_125527_125676_lanthipeptide
17
F F F G Y L L T E G N P D R I F
32
F Y L+T G D R+F
8
L F I V Y L I T I G K I D R L F
23
allorf_5478665_5478787
Leader:
MNPKQAASSVTRRRRSEDRGGA
Core:
G D G S G I W F L S A G W Q G I G C
Core with dehydrations:
G D G Dha G I W F L Dha A G W Q G I G Cys

#### antiSMASH-DB 4.0 matches for allorf_5478665_5478787

100.0%
NZ_CP076103.1:
Lanthipeptides: allorf_5478665_5478787_lanthipeptide
1
G D G S G I W F L S A G W Q G I G C
18
G D G S G I W F L S A G W Q G I G C
1
G D G S G I W F L S A G W Q G I G C
18

#### MIBiG 4.0 matches for allorf_5478665_5478787

10.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
11
A G W Q G I G C
18
W I C
1
C A W Y N I S C
8
allorf_5482973_5483059
Leader:
MLHRNSSPGS
Core:
C D G Y A G T S C M P R K C R G A I
Core with dehydrations:
Cys D G Y A G Dhb Dha Cys M P R K Cys R G A I

#### antiSMASH-DB 4.0 matches for allorf_5482973_5483059

100.0%
NZ_CP011130.1 and 3 others:
NZ_CP023465.1 Lanthipeptides: allorf_5424882_5424968_lanthipeptide NZ_CP076103.1 Lanthipeptides: allorf_5482973_5483059_lanthipeptide NZ_LMHM01000001.1 Lanthipeptides: allorf_734482_734568_lanthipeptide
Lanthipeptides: allorf_5359517_5359603_lanthipeptide
1
C D G Y A G T S C M P R K C R G A I
18
C D G Y A G T S C M P R K C R G A I
1
C D G Y A G T S C M P R K C R G A I
18
26.1%
NZ_CP011305.1 and 5 others:
NZ_CP046588.1 Lanthipeptides: allorf_1748975_1749091_lanthipeptide NZ_CP047310.1 Lanthipeptides: allorf_1658784_1658924_lanthipeptide NZ_CP096975.1 Lanthipeptides: allorf_1778660_1778776_lanthipeptide NZ_JAEDVP010000027.1 Lanthipeptides: allorf_23874_23990_lanthipeptide NZ_RHPZ01000014.1 Lanthipeptides: allorf_016179_016295_lanthipeptide
Lanthipeptides: allorf_1722617_1722733_lanthipeptide
5
A G T S C M P R K C R G A
17
A + +P R C R A
10
A A H A A L P R A C R S A
22
24.1%
NZ_CP013140.1:
Lanthipeptides: allorf_2668303_2668419_lanthipeptide
3
G Y A G T S C M P R K C R
15
G Y A T P K R
10
G Y A F T P L S P S K T R
22
with 2 more sequence matches
21.4%
NZ_FAOZ01000004.1 and 1 other:
NZ_FAOZ01000004.1 Lanthipeptides: AWX74_RS07360_lanthipeptide
Lanthipeptides: AWX74_RS07360_lanthipeptide
2
D G Y A G T S C M P R K C R G A
17
D G T+C P C +
8
D D N C G T T C K P S A C S T S
23
14.6%
NZ_CP086102.1 and 1 other:
NZ_KZ195572.1 Lanthipeptides: allorf_6130947_6131129_lanthipeptide
Lanthipeptides: allorf_6120061_6120243_lanthipeptide
6
G T S C M P R K C R G
16
G T S +P R R G
33
G T S A V P R S G R G
43

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 25.31
Confidence: medium
Additional weak hits (10):
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.85 out of 18.57
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.34 out of 30.22
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.11 out of 18.57
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.96 out of 26.33
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.28 out of 32.74
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.00 out of 30.98
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.52 out of 25.88
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_5468547_5468636 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 1805.0 Da
  Molecular weight: 1806.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1824.2 Da N = 1
    1842.2 Da N = 2
allorf_5469493_5469603 - Class II
  Cleavage pHMM score: -5.40
  RODEO score: 0
  Monoisotopic mass: 2815.4 Da
  Molecular weight: 2817.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2835.1 Da N = 1
    2853.1 Da N = 2
    2871.2 Da N = 3
    2889.2 Da N = 4
    2907.2 Da N = 5
    2925.2 Da N = 6
allorf_5471305_5471397 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 1866.0 Da
  Molecular weight: 1867.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1885.2 Da N = 1
    1903.2 Da N = 2
allorf_5473643_5473795 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 3987.2 Da
  Molecular weight: 3989.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4007.6 Da N = 1
    4025.6 Da N = 2
    4043.7 Da N = 3
    4061.7 Da N = 4
allorf_5478665_5478787 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1773.8 Da
  Molecular weight: 1774.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1793.0 Da N = 1
allorf_5482973_5483059 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 1851.8 Da
  Molecular weight: 1853.2 Da
  Number of bridges: 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CcpA | Catabolite control protein A
MexT | Global virulence regulator

NZ_CP076103.1 - Region 13 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,617,668 - 5,688,221 nt. (total: 70,554 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase glycosyltransferase methyltransferase sulfotransferase transferase
KME82_RS23480: methyltransferase

smcogs
  SMCOG1089: methyltransferase

KME82_RS23515: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

KME82_RS23565: aminotransferase

smcogs
  SMCOG1019: aminotransferase

KME82_RS23570: glutathione S-transferase

smcogs
  SMCOG1193: glutathione S-transferase

KME82_RS23625: glycosyltransferase

smcogs
  SMCOG1102: glycosyltransferase

Hydrolases: hydrolase
KME82_RS23495: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: ligase synthase
KME82_RS23510: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

KME82_RS23525: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KME82_RS23530: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KME82_RS23535: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KME82_RS23620: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.74 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.74 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.73 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.72 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.72 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.71 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.70 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.74 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.74 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.73 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.72 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.72 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.71 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.70 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.76 out of 32.74
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.24 out of 19.26
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.24 out of 19.26
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.13 out of 18.57
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 23.57 out of 27.55
Confidence: medium
Additional weak hits (16):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.71 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.05 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.33 out of 28.14
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.22 out of 21.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.82 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.63 out of 27.78
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.06 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.76 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.29 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.49 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.42 out of 26.06
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.84 out of 30.98
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 28.19
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.43 out of 24.78
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.96 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 13, location 5617667 - 5688221:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ala) + (Gly) + (X) + (Gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KME82_RS23525: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (506..899): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSVSFDIALFELQAISTGEWNLYGPTETTVYSAL
  Nearest Stachelhaus code(s):
    Ala DILQITLVYK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

KME82_RS23530: Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (510..902): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIALLELQALCGGEWNLYGPTETTVWSTV
  Nearest Stachelhaus code(s):
    Gly DILQLGLVWK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

KME82_RS23535: X
AMP-binding (537..940): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGFPFDASVGDPDAMIGGESNHYGPTETSVCAAM
  Nearest Stachelhaus code(s):
    CysA DATKMGHVGK (50% 8Å match)
  Stachelhaus code match:
    70% (weak)

KME82_RS23620: Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (462..859): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FATTFDIACFELQALSTGETNLYGPTETTVWASA
  Nearest Stachelhaus code(s):
    Gly DILQLGLVWK (82% 8Å match)
  Stachelhaus code match:
    80% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
FuR variant 2 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP076103.1 - Region 14 - arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 5,748,863 - 5,790,068 nt. (total: 41,206 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KME82_RS23950: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: halogenase sulfotransferase
KME82_RS23865: glutathione S-transferase

smcogs
  SMCOG1193: glutathione S-transferase

KME82_RS24000: conventional flavin-dependent halogenase

halogenases
  conventional flavin-dependent halogenase
smcogs
  SMCOG1119: halogenase

Hydrolases: hydrolase
KME82_RS23880: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Ligases: synthase
KME82_RS23925: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KME82_RS23935: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002341.2 |  | 0.76 | other (other) | 3,5-dibromo-p-anisic acid | Planctomycetales bacterium 10988
BGC0002608.2 |  | 0.76 | NRPS, PKS | ochratoxin A | Aspergillus steynii
BGC0000840.5 |  | 0.66 | other (other) | xanthomonadin I | Xanthomonas oryzae pv. oryzae
BGC0000867.3 |  | 0.48 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0002510.2 |  | 0.44 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0001987.2 |  | 0.44 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0002008.3 |  | 0.42 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0000837.4 |  | 0.42 | other (other) | APE Vf | Aliivibrio fischeri ES114
BGC0000836.5 |  | 0.42 | other (other) | APE Ec | Escherichia coli CFT073
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002341.2 |  | 0.76 | other (other) | 3,5-dibromo-p-anisic acid | Planctomycetales bacterium 10988
BGC0002608.2 |  | 0.76 | NRPS, PKS | ochratoxin A | Aspergillus steynii
BGC0000840.5 |  | 0.66 | other (other) | xanthomonadin I | Xanthomonas oryzae pv. oryzae
BGC0000867.3 |  | 0.48 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0002510.2 |  | 0.44 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0001987.2 |  | 0.44 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0002008.3 |  | 0.42 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0000837.4 |  | 0.42 | other (other) | APE Vf | Aliivibrio fischeri ES114
BGC0000836.5 |  | 0.42 | other (other) | APE Ec | Escherichia coli CFT073
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.96 out of 29.72
Confidence: medium
Additional weak hits (5):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.71 out of 25.75
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.56 out of 31.73
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.76 out of 20.01
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.76 out of 30.25
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C

NZ_CP076103.1 - Region 15 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,024,168 - 6,068,031 nt. (total: 43,864 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
KME82_RS25090: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

KME82_RS25095: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KME82_RS25125: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Hydrolases: dehalogenase
KME82_RS25140: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Ligases: ligase
KME82_RS25120: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KME82_RS25135: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.64 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.64 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001240.4 |  | 0.63 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.65 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001825.4 |  | 0.64 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.64 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  | 0.64 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001240.4 |  | 0.63 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.72 out of 27.78
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.35 out of 27.04
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.99 out of 20.47
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.79 out of 21.84
Confidence: medium
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.42 out of 27.18
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
Additional weak hits (17):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.13 out of 30.97
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.41 out of 21.55
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.93 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.90 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.46 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.70 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.01 out of 30.25
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.76 out of 27.55
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.88 out of 32.74
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.42 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.91 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.26 out of 26.06
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.31 out of 20.97
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.19 out of 35.63
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.65 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 15, location 6024167 - 6068031:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KME82_RS25120: NH2
CAL_domain (147..464): NH2
minowa: NH2

Prediction, score:
  NH2: 33.7
  fatty_acid: 27.1
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

KME82_RS25135: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (486..876): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDVSFDLSVYDGNSMLSGDISLGGATEASIWSIW
  Nearest Stachelhaus code(s):
    Cys DLYNMSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
DasR | N-acetylglucosamine dependent repressor
MexT | Global virulence regulator
NrdR | Represses ribonucleotide reductase encoding genes
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP076103.1 - Region 16 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,180,782 - 6,191,633 nt. (total: 10,852 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000515.4 |  | 0.32 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0001727.3 |  | 0.31 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0001789.3 |  | 0.31 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.31 | ribosomal | nisin U | Streptococcus uberis
BGC0000536.3 |  | 0.31 | ribosomal | nisin Q | Lactococcus lactis
BGC0000535.4 |  | 0.31 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000188.5 |  | 0.31 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001650.4 |  | 0.30 | NRPS | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0000549.3 |  | 0.30 | ribosomal | salivaricin D | Streptococcus salivarius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000515.4 |  | 0.32 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0001727.3 |  | 0.31 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0001789.3 |  | 0.31 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.31 | ribosomal | nisin U | Streptococcus uberis
BGC0000536.3 |  | 0.31 | ribosomal | nisin Q | Lactococcus lactis
BGC0000535.4 |  | 0.31 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000188.5 |  | 0.31 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0001650.4 |  | 0.30 | NRPS | Le-pyrrolopyrazines | Lysobacter enzymogenes
BGC0000549.3 |  | 0.30 | ribosomal | salivaricin D | Streptococcus salivarius

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
Additional weak hits (3):
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.63 out of 18.57
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 17.49 out of 30.97
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.41 out of 26.33
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
AfsR | Pleiotropic regulatory for antibiotic production
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP076103.1 - Region 17 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,207,937 - 6,219,196 nt. (total: 11,260 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase
KME82_RS26015: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

Isomerases: isomerase
KME82_RS26010: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001157.6 |  | 0.35 | ribosomal | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000468.5 |  | 0.34 | ribosomal | bottromycin A2 | Streptomyces bottropensis DSM40262
BGC0000470.6 |  | 0.34 | ribosomal | bottromycin D | Streptomyces sp. WMMB272
BGC0002031.3 |  | 0.33 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0000469.6 |  | 0.33 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0002485.2 |  | 0.31 | other (other), ribosomal | muscoride A, muscoride B | Desmonostoc sp. PCC 7906
BGC0000565.5 |  | 0.30 | ribosomal | goadsporin | Streptomyces sp. TP-A0584
BGC0002439.3 |  | 0.29 | other (other) | diastaphenazine, izumiphenazine C | Streptomyces diastaticus
BGC0001529.5 |  | 0.29 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0002474.2 |  | 0.29 | NRPS | agrobactin | Agrobacterium tumefaciens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001157.6 |  | 0.35 | ribosomal | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000468.5 |  | 0.34 | ribosomal | bottromycin A2 | Streptomyces bottropensis DSM40262
BGC0000470.6 |  | 0.34 | ribosomal | bottromycin D | Streptomyces sp. WMMB272
BGC0002031.3 |  | 0.33 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0000469.6 |  | 0.33 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0002485.2 |  | 0.31 | other (other), ribosomal | muscoride A, muscoride B | Desmonostoc sp. PCC 7906
BGC0000565.5 |  | 0.30 | ribosomal | goadsporin | Streptomyces sp. TP-A0584
BGC0002439.3 |  | 0.29 | other (other) | diastaphenazine, izumiphenazine C | Streptomyces diastaticus
BGC0001529.5 |  | 0.29 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0002474.2 |  | 0.29 | NRPS | agrobactin | Agrobacterium tumefaciens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
Additional weak hits (3):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.77 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.64 out of 29.65
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.12 out of 26.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence
VqsM | Regulator of quorum-sensing signalling systems