LOCUS       NZ_JAHFZZ010000008     22760 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Nonomuraea sp. NEAU-A123 Scaffold8, whole genome shotgun sequence.
ACCESSION   NZ_JAHFZZ010000008
VERSION     NZ_JAHFZZ010000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nonomuraea sp. NEAU-A123
  ORGANISM  Nonomuraea sp. NEAU-A123
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 558580)
  AUTHORS   Zhang,L. and Zhao,J.
  TITLE     Nonomuraea triticisoli sp. nov., a novel actinobacterium isolated
            from rhizospheric soil of wheat in Langfang, Hebei Province, China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 558580)
  AUTHORS   Zhang,L. and Zhao,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2021) College of Life Sciences, Northeast
            Agricultural University, Changjiang Road No. 600, Xiangfang
            District, Harbin, Heilongjiang Province 150036, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018603905.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 04:26:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,983
            CDSs (total)                      :: 11,901
            Genes (coding)                    :: 11,761
            CDSs (with protein)               :: 11,761
            Genes (RNA)                       :: 82
            rRNAs                             :: 5, 3, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 2, 3 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 140
            CDSs (without protein)            :: 140
            Pseudo Genes (ambiguous residues) :: 0 of 140
            Pseudo Genes (frameshifted)       :: 28 of 140
            Pseudo Genes (incomplete)         :: 121 of 140
            Pseudo Genes (internal stop)      :: 3 of 140
            Pseudo Genes (multiple problems)  :: 12 of 140
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:52:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 293731
            Orig. end                         :: 316491
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHFZZ010000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22760
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iv"
                     /region_number="2"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     cand_cluster    1..22760
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22760
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12760](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12760
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     gene            complement(100..507)
                     /locus_tag="KLK06_RS26500"
                     /old_locus_tag="KLK06_26495"
     CDS             complement(100..507)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019013.5"
                     /locus_tag="KLK06_RS26500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26495"
                     /product="ester cyclase"
                     /protein_id="WP_214638324.1"
                     /sec_met_domain="PF07366 (E-value: 1.7e-37, bitscore:
                     123.0, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYETNLAAQQRFATAVMSGDFAIFDEVVAPDAVDHDPAPVQGPG
                     PEGYKALFAEMRTAFPDLHVEVEHLTATEDELAFAYTISGTHLGDLMGHPATGKKVSYR
                     GMQISRFADGKLVERWGSSDQLGMLAQLGLL"
     gene            complement(773..1240)
                     /locus_tag="KLK06_RS26505"
                     /old_locus_tag="KLK06_26500"
     CDS             complement(773..1240)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012306492.1"
                     /locus_tag="KLK06_RS26505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26500"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_214638325.1"
                     /transl_table=11
                     /translation="MTTRPPLPPFTRESAIEKVRLAEDGWNTRDPEKVALAYSKDSRWR
                     NRAEFATGHDEIVAFLRRKWARGLDYRLIKELWAFTGDRIAVRFAYEWHDDAGNWFRSY
                     GNENWEFDEQGLMRARHASINDLPIQESDRKYHWPLGRRPDDHPGLTDLGF"
     gene            1648..2382
                     /locus_tag="KLK06_RS26510"
                     /old_locus_tag="KLK06_26505"
     CDS             1648..2382
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019349.5"
                     /locus_tag="KLK06_RS26510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26505"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_214638326.1"
                     /transl_table=11
                     /translation="MAERPGRTRTEEPAAKRRRPRAGSGQSLGDQAYEHIRAAILQGRY
                     RPNQRLPEDEVAAQLNSSRTPVRVALMRLVDQGLVVRERQGWVVREHTPDEIREIYEVR
                     CALEAMATGLAAVRASEEQLGRIAAFYDGPIEEYVQRPRAELGRMNRDFHLAIVQASGN
                     GRLLDEWLRNRDFGITYNMAVLFTRDEVVTCVEGHQRIVEALMRRDRESAERHARIHVE
                     DVQAAASRRLDALQTSVGLYLS"
     gene            complement(2392..2970)
                     /locus_tag="KLK06_RS26515"
                     /old_locus_tag="KLK06_26510"
     CDS             complement(2392..2970)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1148: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019607445.1"
                     /locus_tag="KLK06_RS26515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26510"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_214638327.1"
                     /transl_table=11
                     /translation="MKQDGDLDGLVRMRIRGLRTARGWSLDDLAARCYLSPSTLSRIET
                     GHRRISLDQLTAIARALETTLDQLVESATDDDVVIRPQRDEARGMTTWTLSREPGPHGM
                     TVAKIRLTKPPPRRDTAELGVHPGRDWFTVLSGTVVLLLGERTILVEAGQAAEFATMIP
                     HAFGAHDGPAEILTILDHDGQRTHLRRAP"
     misc_feature    complement(2936..2951)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.83"
                     /tool="antismash"
     gene            3018..3878
                     /locus_tag="KLK06_RS26520"
                     /old_locus_tag="KLK06_26515"
     CDS             3018..3878
                     /NRPS_PKS="Domain: oMT (28-154). E-value: 8.4e-10. Score:
                     29.2. Matches aSDomain: nrpspksdomains_KLK06_RS26520_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017597580.1"
                     /locus_tag="KLK06_RS26520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26515"
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_214638328.1"
                     /sec_met_domain="PCMT (E-value: 1.4e-06, bitscore: 23.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATHQHQDHHSAAGTDDMAMAELLDLDAEVLHSYLSELTAWIGGF
                     AADPAPRRILDLGSGTGTGTFALLERFVQADATALDISAPLLHHLRNKADELGMADRVR
                     TIQADLDATWPDIAPVDLVWASASLHHMADPDRMLTSVFAALRPGGLLVAVEMDSFPRF
                     LPEDLGIGRPGLEARCHAAMAEEHAVHVPHLGSDWGPRLIVAGFTIEAERTFAVDLTPP
                     LPASAARYAQASLRRLRSGLKDRLSAGDLAALDALLDGDGPEGILRRGDLHVRTARTVW
                     VARRP"
     aSDomain        3102..3479
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KLK06_RS26520_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="8.40E-10"
                     /label="KLK06_RS26520_oMT.1"
                     /locus_tag="KLK06_RS26520"
                     /protein_end="154"
                     /protein_start="28"
                     /score="29.2"
                     /tool="antismash"
                     /translation="EVLHSYLSELTAWIGGFAADPAPRRILDLGSGTGTGTFALLERFV
                     QADATALDISAPLLHHLRNKADELGMADRVRTIQADLDATWPDIAPVDLVWASASLHHM
                     ADPDRMLTSVFAALRPGGLLVA"
     gene            3940..4550
                     /locus_tag="KLK06_RS63130"
                     /old_locus_tag="KLK06_26520"
                     /pseudo=""
     CDS             3940..4550
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024950.5"
                     /locus_tag="KLK06_RS63130"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26520"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKQTLETLDPNLYPTLQAVRTTVNAYGRLDIAVSTPGINIRKRMA
                     AYTEEEFDRIVGLNLKGTFFFLQETSAVMAEQGGGSIIACSSMRALMVEPGSACTPPRR
                     RPSCRWRAASPPRSARRGSGSTPSRPGSSTRRSPGRCGTTSRPGTPTARTPSSAGGAAL
                     TRSPPRWPSSPVTRPRTSPGPTSSSTRAGPSSTTASTRDA"
     misc_feature    complement(3985..4001)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.75"
                     /tool="antismash"
     gene            4604..5443
                     /locus_tag="KLK06_RS26530"
                     /old_locus_tag="KLK06_26525"
     CDS             4604..5443
                     /NRPS_PKS="Domain: Abhydrolase_1 (21-262). E-value:
                     3.3e-28. Score: 90.9. Matches aSDomain:
                     nrpspksdomains_KLK06_RS26530_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020543408.1"
                     /locus_tag="KLK06_RS26530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26525"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_214638330.1"
                     /sec_met_domain="PF00561 (E-value: 7.5e-24, bitscore: 79.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1e-15, bitscore:
                     53.9, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAFSAHDGTDLAYHVFGEGVPVICLPGGPMQDTDYLGELGGLSA
                     HRQLIMVDLRGTGRSAIPADAASYRCDRLVDDVEALREHLGLDRFDLLAHCAGANLAAL
                     YAARHPERVGKLALITPSTFAVGIAPTGESRLEIARLREDEPWFPAAFAALEAIVAGNA
                     TDGSRQAIDPFFYGRWDAAAQAHHAAQNGHRNDEAAAAFGAEGAYDPDATRAALSAFSA
                     PVLLLAGEVDLNSIPSAVAAFAELFPNAEFAVQPAAGHFPWTDDADRFVATTATFLG"
     aSDomain        4667..5389
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KLK06_RS26530_Abhydrolase_1.1"
                     /evalue="3.30E-28"
                     /label="KLK06_RS26530_Abhydrolase_1.1"
                     /locus_tag="KLK06_RS26530"
                     /protein_end="262"
                     /protein_start="21"
                     /score="90.9"
                     /tool="antismash"
                     /translation="PVICLPGGPMQDTDYLGELGGLSAHRQLIMVDLRGTGRSAIPADA
                     ASYRCDRLVDDVEALREHLGLDRFDLLAHCAGANLAALYAARHPERVGKLALITPSTFA
                     VGIAPTGESRLEIARLREDEPWFPAAFAALEAIVAGNATDGSRQAIDPFFYGRWDAAAQ
                     AHHAAQNGHRNDEAAAAFGAEGAYDPDATRAALSAFSAPVLLLAGEVDLNSIPSAVAAF
                     AELFPNAEFAVQPAAGHFP"
     gene            complement(5448..5804)
                     /locus_tag="KLK06_RS26535"
                     /old_locus_tag="KLK06_26530"
     CDS             complement(5448..5804)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895186.1"
                     /locus_tag="KLK06_RS26535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26530"
                     /product="DoxX family protein"
                     /protein_id="WP_214638331.1"
                     /transl_table=11
                     /translation="MFTTYVVVAVMTIVVNVGAAVADFARARLVVANAAEVGVPPSWLP
                     LLATLKLAGAAGLMLGLVGVPFVGLAAATGLVLFFVGAVAAHVRARVLYNVAFPGGFLA
                     LAIASLVLGAAVPG"
     misc_feature    complement(5834..5850)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 19.11"
                     /tool="antismash"
     gene            6607..7920
                     /locus_tag="KLK06_RS26545"
                     /old_locus_tag="KLK06_26540"
     CDS             6607..7920
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1206: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020547993.1"
                     /locus_tag="KLK06_RS26545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26540"
                     /product="ISL3 family transposase"
                     /protein_id="WP_214638333.1"
                     /transl_table=11
                     /translation="MVNDTTLLLGLDGVAVTKVVAAGDGAQDGPVVHLSTADERARCCP
                     QCGVAAVRMKEWVTTRPRDLPMGGRHCRLRWRKRRWWCDQQRCPRRTFTEQVPQIPARS
                     RLTRRLRQATGAAVGDGGRTVIQSARDHQVSWPIVCAAFTEHARQVLPVQPEPVSVLGI
                     DEIRRGRPHWVLDEATGTWSTAVDRWHTGFVDLSGDQGLLGQVEGRTIAAVTGWLNQRS
                     QAWRGQVAFVAIDMCTIFKSAVRTALPRARLVIDHFHVVQLANQALTEVRRRVTVQIRG
                     RRGRKGNREWELRNRLTRSAARMHACQLDPMVDDLHALGRIGTPILAAWNAKEDLLDLA
                     RTHPDRTVIADRLFRFYDRCAASGLPELERLATTIDTWWPEILTFIQTGITNAGSEGTN
                     RVIKTVARDAYGFRNPENQRLRTRCATTRKGRGCLNPA"
     misc_feature    6934..6936
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    7864..7866
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8892..9503)
                     /locus_tag="KLK06_RS26550"
                     /old_locus_tag="KLK06_26545"
     CDS             complement(8892..9503)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS26550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_26545"
                     /product="hypothetical protein"
                     /protein_id="WP_214638334.1"
                     /transl_table=11
                     /translation="MSTDVPNTLVYVERELILPVAVKLVGSSLATKNSENLAGGINWLV
                     TTRFGLGSENSAETRLADLFPEDIFSFAYPKIRDKDLRVRGFAKEVSERRVAPPDVVSV
                     NGVLRLPELGTKARDPFSPDAVEVQHTHKIYGFNCFTGILEDDGFRIPLYFLLDSARIV
                     SYAHEKPVEVVGVAKWSPTYEVAGHAVNCSLLVAALLLRR"
     misc_feature    complement(9607..9621)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            10001..12760
                     /gene="lanL"
                     /locus_tag="KLK06_RS26555"
                     /old_locus_tag="KLK06_26550"
     CDS             10001..12760
                     /codon_start=1
                     /gene="lanL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038150.1"
                     /locus_tag="KLK06_RS26555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26550"
                     /product="class IV lanthionine synthetase LanL"
                     /protein_id="WP_214638335.1"
                     /sec_met_domain="Pkinase (E-value: 2.5e-16, bitscore: 54.8,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 6.2e-37, bitscore:
                     122.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGADATILRDLVTAELARSGEAGWSVEASDFWCRVTPDGYPMPEQ
                     GWKLHVSATMLSAPFVLAQVARVLIEAGCAFKFPAELGAYWELLSPHCARAQAGKFVTA
                     YPADDAESIRLAALLDEATRGLPGPVILSDRPYRAGGIVHYRYGAFSGHRTLGNDGFYE
                     VRLRAPGGELVRDQRTAAFTPPSFAASPFQRLGFQRLGGPSKASAVMLNDRFVVREAIR
                     HANRGGVYLAEDTKTGREVIIKEGRPHASSDLSGRDARVRLAAERAALDDLAATDGVPA
                     VVDYFEQGGHAFLAEELVPGRTAHRWSEAHATPLGPDGFGCAVEEVVPVVSRLVGLLRE
                     VHRHGYVFRDLSPGNVMILPDGQVRLVDLEYAAKQGTTVMIGGTPGYLAPELAPHTGAF
                     HQAPPATADLYSLGALTYFLAVGADLGLAEDLSEDEAAGLAWGTRTADHLARVAESNPT
                     LAALRPMVAGLLAEPDDRWTLDACTRFLADLGQPDVRPAPHPRVTADDLISDGLAWLAE
                     TMDDRPDCPSPWPNITYGLEADPCSVSAGAAGILAVLPPEQTGAVSRWLRRRLAEEDVW
                     PPGLYAGRSGALWALYEAAADEESRDFAVRAAYRLPTDHPSPDVTHGLAGCAMATLRLA
                     IRADDPALRERATEMLQNLHDARSSYEGRPQWPTQATLDSSLAGTNHFGFAHGLAGVGT
                     ALLYGGVALGRADWMETVREVAHALYEHADVDGDTAWWPFRRDERESVRPRRPHWCSGS
                     SGVGSFLIRYWNATNDPAALELAEHAAIAVHRTRWQSGSALCHGLPGEGDFLLDMARFT
                     ADERYHRWAEDLAACLSARAVRHAGRLHVPDRLGRTVPTYLGGTAGVLAFLLRLRHGHP
                     RLWMLDDVIGAPHDLAVPRARRRQEERKSERGEKHVFRRSGPAEPAGA"
     gene            12906..14735
                     /locus_tag="KLK06_RS26560"
                     /old_locus_tag="KLK06_26555"
     CDS             12906..14735
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="KLK06_RS26560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26555"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_214638336.1"
                     /transl_table=11
                     /translation="MTTRRIIRLFTPYRRAVLLVVLLVAIFSALNAAIPLLTQVVFDRA
                     LFGKDGPRPDLLALIAALAAVTAAGAAGVDLAQTWVSARMAQRVIHSLRTRLFGHLQRM
                     PLGFFAAARSGEIQSRLANDTNQIEDAIKDTLPSLLGSLLAFLFALGAMFSLSWPLASV
                     TLCLAPAILWVSARSGRALKVLSVAGQRARAEIASIAAERLSLGGITLARVHGRDSHEA
                     AVFGAESERLARLGVRAGLAAQSVLSAGHIFFVLTPYIVFVAAGLMDGITPGTLIAFVV
                     LQSRLYQPLWQILHISTEFRTAQAAFERVFEYLDLPPGPPPAVRGGGAGEVRVAGASYA
                     YAGPEGEARWALREVTLDLPAASATLIVGPNGSGKTTLGYLLAGLYEPAEGTVRIDGRV
                     CLAPQEALLFQGSIAENLRYAAPEAGLDDLVAACTTTRMHDRIMALPDGYDSVVGERGA
                     LFSGGERQRIALARALLSDAPVLVLDEATSALDPLTEREVIHAVLLRRRGMTTVMITHR
                     FGGLDAFDTVVVLDEGRVVERGAHPELLGNRHGLYARMVRAQAVQRGDPADGEGAVIDL
                     PSSLLSTGPACRCSGSVRQLSMDGQMSRIDYEA"
     gene            14701..15372
                     /locus_tag="KLK06_RS26565"
                     /old_locus_tag="KLK06_26560"
     CDS             14701..15372
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS26565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_26560"
                     /product="NYN domain-containing protein"
                     /protein_id="WP_214638337.1"
                     /transl_table=11
                     /translation="MARCRESTTKRDRFRYGRLVAGRTNWQTADVDRVVYCTARIDGAD
                     NPDGQRDQSVYINALRASGSVDHIEFGYCVSRVKYAPLAVRDRAGRPVLARPTWPIQVC
                     DSAGASVPGASFMVSYAYREEKGSDVNVASHLLLDVFKGVVDAAVVISNDSDLRFPIEQ
                     VRQHVPVGLVNPSGNYLAGALRGQAADGVGRHWWYQLTAGDLIKCQLPSTVSAYTRPPG
                     W"
     gene            15636..16592
                     /gene="pip"
                     /locus_tag="KLK06_RS26570"
                     /old_locus_tag="KLK06_26565"
     CDS             15636..16592
                     /EC_number="3.4.11.5"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0030163 - protein catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (36-299). E-value:
                     3.6e-34. Score: 110.4. Matches aSDomain:
                     nrpspksdomains_KLK06_RS26570_Abhydrolase_1.1"
                     /codon_start=1
                     /gene="pip"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019630626.1"
                     /locus_tag="KLK06_RS26570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26565"
                     /product="prolyl aminopeptidase"
                     /protein_id="WP_214638338.1"
                     /sec_met_domain="PF00561 (E-value: 1.4e-31, bitscore:
                     105.0, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-11, bitscore:
                     40.1, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQKTFYPPIEPYETGMLEVGDGNEIYWEVCGNPDGKPVVFLHGG
                     PGGGLLPAQRRFFDPEAYKIVLFEQRNCGRSRPHAADPGVSLEANTTWHLVADIERLRQ
                     WLGIERWQVFGGSWGSTLALAYARRHPERVSELVLRGVYLATEADNVWAFTGTGAARLF
                     PREWAAFRDFIPEAERDDLVAAYHRRLSDPDPEVHLPAARAWAAWELSANTLLPAAPPP
                     LDDRELVSFSRIEAHYFSQGCFLKDGELLDVAAIRHIPCVIVNGRYDMKTPPDAAWDLQ
                     LAWPEAELRIVEDAGHAGAEPGTLHELITATDGYRHL"
     aSDomain        15744..16532
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KLK06_RS26570_Abhydrolase_1.1"
                     /evalue="3.60E-34"
                     /label="KLK06_RS26570_Abhydrolase_1.1"
                     /locus_tag="KLK06_RS26570"
                     /protein_end="299"
                     /protein_start="36"
                     /score="110.4"
                     /tool="antismash"
                     /translation="KPVVFLHGGPGGGLLPAQRRFFDPEAYKIVLFEQRNCGRSRPHAA
                     DPGVSLEANTTWHLVADIERLRQWLGIERWQVFGGSWGSTLALAYARRHPERVSELVLR
                     GVYLATEADNVWAFTGTGAARLFPREWAAFRDFIPEAERDDLVAAYHRRLSDPDPEVHL
                     PAARAWAAWELSANTLLPAAPPPLDDRELVSFSRIEAHYFSQGCFLKDGELLDVAAIRH
                     IPCVIVNGRYDMKTPPDAAWDLQLAWPEAELRIVEDAGHAG"
     gene            16657..17109
                     /locus_tag="KLK06_RS26575"
                     /old_locus_tag="KLK06_26570"
     CDS             16657..17109
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS26575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_26570"
                     /product="hypothetical protein"
                     /protein_id="WP_214638339.1"
                     /transl_table=11
                     /translation="MAFPIMKLAAALMFACPSPVPVAPAGTALLQSGEIRFHTINEAKD
                     TETIVTVTVRDRRGQTIALLTGVLGQWAENAWSARIPLNVISPPGDLARLWGGTINVRI
                     DPKGEDAWAFTFHTYLRFSNGETADVYQRQLAVVNEGRRDWTTIIR"
     gene            complement(17229..20729)
                     /locus_tag="KLK06_RS26580"
                     /old_locus_tag="KLK06_26575"
     CDS             complement(17229..20729)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012890177.1"
                     /locus_tag="KLK06_RS26580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26575"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_214638340.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.2e-31, bitscore:
                     105.1, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSTPHWRAILIAVAAAVTLILPQGVAQAAPDPGKINKSVQADLA
                     ADGKATFWVRMKGTADLSGARRATTKDDKAEQVFEAKTAKADTSQAALRKLLESHQADY
                     TPYWIVNAVRVTADAKLAAEIAALADVERIDPVRTVSLPKPDPGKAEAKVNAVEWNIDR
                     INAPRVWNELTDRGEGIVVGTIDSGAQFDHPELAAAYRGRSPDGSLDHNYNWFDPAHIC
                     PSAVPCDNLGHGTHVMGTMVGANGIGVAPGAKWIAAKGCEVNTCTDASLLAAGQWMLAP
                     TDLNGANPRPDLAPDIVNNSWGGAGFDPWYKETVEAWIAAGIFPAFANGNEGPACRTSG
                     SPGQYAISYSAGGFDINNVLYARSSKGEGENGEIKPNLAAPAVNVRSSVPGNGYDSYTG
                     TSMASPHLAATVALIWSASPGLQGDVAATRPLLDSTAIDVNDTSCGGTAADNNVWGEGR
                     LDAFAAVQAAPRGGLGDLKGTVTAGGSPVSGATVNLSGPLSRTVITGSDGTYAIPRLLP
                     GDYQIAAEKFGYDKGTATATITAEQSTTADVAMTLQAAGVVTGTVSTAGTPEPGAKIEA
                     VGTPVSAVTDAAGRYRLSLPNGTYDLKITPVSRCSSGATASVTVAGDVTKDIELPLRGD
                     NFGYTCRSAAEPYVAGTEKLALTGDDEAQQVNLPFPVPFYGVGQSRAWISTNGFATFAT
                     DKIVTGSNGRLPSTATPNNAVYPYWDDLVVDADSGIYTGVTGTAPHRQFVVEWRNVKFY
                     SATDQRVSFAALLGEDGTMSYRYKDIESERDKGTSATVGVENAAGTDAFQYSYEEVALA
                     NGQSLTFIASRHGLVTGTVTDANDGKPLAGATVKVGDVATYTTGEDGAFYGQVLAGDYE
                     VQVSKEHYGTFTKTVTIAPTTVTRIDTALITGRVSPSVSELTVVLPTNATRTRTMELTN
                     LGSPTAYTVTTDPAQGWIGVTPTAGDLAKGQAVTLKVTVSSAGVLPGTLRSGKLIVKSA
                     SGRQPVIEIAVTVVVPKLQVAVEAGGTKAVTDTAGDAWTPDKKYTAGGYGYIATSTSTS
                     TSSKTIKGTDDQALFKTAREGMLEYRFDNVPAGTYTVELDFADVKSTQIGRRVFDVLVE
                     GQLAIPALDLALEAGTYTAVSRQYTVKVTDGQLNVRFATREGKTIVNAIRISERPDKVS
                     "
     misc_feature    complement(20211..20213)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(20874..20889)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 21.05"
                     /tool="antismash"
     gene            complement(20880..21653)
                     /locus_tag="KLK06_RS26585"
                     /old_locus_tag="KLK06_26580"
     CDS             complement(20880..21653)
                     /GO_function="GO:0016765 - transferase activity,
                     transferring alkyl or aryl (other than methyl) groups
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020545428.1"
                     /locus_tag="KLK06_RS26585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26580"
                     /product="isoprenyl transferase"
                     /protein_id="WP_214638341.1"
                     /transl_table=11
                     /translation="MNVRPPTPHPSGAVPPPIPRDLVPKHVAIIMDGNGRWAKARGLPR
                     TEGHKAGEASLFDVIEGALELGIPYLSAYAFSTENWKRSPDEVRFLMGFNRDVIRRRRD
                     ELHAMGVRVRWAGKPGRLWKSVISELQSAEELTERNRKLTLQFCVNYGGQAEIVEAALR
                     LANDIAAGRVKPSKVNEKVFARYLDEPEIPEVDLFVRSSGEQRFSNFLLWQSAYAEMVF
                     LDRLWPDFDRRDLWEACEIYAKRDRRYGGALPNQV"
     gene            complement(21650..22384)
                     /gene="recO"
                     /locus_tag="KLK06_RS26590"
                     /old_locus_tag="KLK06_26585"
     CDS             complement(21650..22384)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recO"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012889060.1"
                     /locus_tag="KLK06_RS26590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_26585"
                     /product="DNA repair protein RecO"
                     /protein_id="WP_214638342.1"
                     /transl_table=11
                     /translation="MSLYRDEGVILRTQKLGEADRIVTILAKRTGKVRAVAKGVRRTTS
                     RFGARLEPFTHVDLQLHTGRTLDVVTQAETIRPYGEALAIDYPRYTAGTAMLETADRLT
                     HGEKEPALRQFLLLVGGLRTLADGEHEARLVLDAYFLRSLAVAGYAPALDACARCRAPA
                     IRAFAIVAGGVVCGACKPAGSVVPAGETIGLMTALLRGDWAAADASQARHRGECSGLVA
                     AYLQWHLEHGIRSLRHVEREPV"
ORIGIN
        1 ctgttcccgc gctgatggag atttccggcc tgtaggcgcg gagacgtgga acggccggtc
       61 ccgggtggac aggccgttcc acgtgcgtgg tgggcggggt cagaggaggc cgagctgggc
      121 gagcatgccg agctggtcgc tgctgcccca ccgctccacc agcttgccgt cggcgaagcg
      181 gctgatctgc atgccgcggt agctgacctt cttgccggtg gcggggtggc ccatgaggtc
      241 gcccaggtgg gtgccgctga tggtgtaggc gaaggccagc tcgtcctcgg tggcggtcag
      301 gtgctcgacc tcgacgtgca ggtccgggaa cgcggtacgc atctcggcga acagggcctt
      361 gtacccctca ggccccggtc cctgcaccgg cgcgggatcg tggtccacgg catcgggcgc
      421 gaccacctcg tcgaagatgg cgaagtcgcc gctcatcacg gcggtggcga agcgctgctg
      481 ggccgcgagg ttggtttcgt aggtcatgtc tctcctcagg gtcacgtcca cggacgtgct
      541 gcacatggat cttcgcgtga ccctgtttct gcaggttaag cggtacgtgc ctgcgggagc
      601 gggagccggg cgggcgggcc ccggagcggc tgcggacagg ccggtgcctg ttggacccag
      661 ctcgctgaac agggctgagg gtcgccggcg gtcgtcagcg cacggatgcg acccgtgtgt
      721 tggcggcgat ccggaacacc tggtgccgct tatccggttc gacagtggtc ggtcagaagc
      781 cgagatcggt caggcccggg tgatcgtccg ggcggcgccc caggggccag tggtacttcc
      841 ggtccgactc ctggatcggc aggtcgttga tgctcgcatg ccttgcccgc atcaggccct
      901 gctcgtcgaa ctcccagttt tcgttcccgt acgagcggaa ccagttgccc gcgtcgtcat
      961 gccactcgta ggcgaagcgg accgcgatcc ggtccccggt gaaggcccac agctccttga
     1021 tcagccggta gtcgagccct ctggcccact tccgccggag gaacgccacg atttcatcat
     1081 gtcccgtcgc gaactccgcc cggttccgcc agcgtgaatc cttggagtag gccagcgcca
     1141 ccttctcggg gtccctggtg ttccagccgt cttccgccag ccggactttc tctatggcgc
     1201 tctcgcgggt gaacggaggc aatgggggtc gcgttgtcat ctcgtctcct cagtcgtcgc
     1261 agttccgcac cacagcgcga ccgatccccg accgccgttt ccgccgactg ccagcttcac
     1321 ggttgcgacc gtgattgcag gatacttctc cggcctgagg cgccttggga cggcctgccc
     1381 cgcggtcgag cgggatcccg tcggcgggcg ggttgacgcc gctggccttg accagtacct
     1441 ggcccgggcc ggcggcgggt ttctccatct cgctcaggat cagcggagtg ccgaactctt
     1501 ggagaaccac tacgcctcct ttctgtcttg tcgggtggct gtggggcacc ggcgaaaacg
     1561 gcggccatgc cgggatttct ggatctcacc gcatactgga agaatctcga tgaacaacgg
     1621 cctgacaggc gacggaccgg aggattgatg gccgaacgac ccggcaggac acgtacggag
     1681 gagcctgcgg ccaagcgcag gaggcctcgt gcgggtagcg ggcagtcgct cggcgaccag
     1741 gcatacgagc acatacgggc cgcgatcctc cagggcagat accgccccaa ccagcggctg
     1801 ccggaagacg aggtggcggc gcagctcaac agcagccgca ctcccgtacg cgtcgccctg
     1861 atgcggctgg tcgatcaggg gctggtcgtc cgggagcggc agggctgggt ggtgcgcgag
     1921 cacacgccgg acgagatccg cgagatctac gaggtgcggt gcgccctcga ggcgatggcc
     1981 accgggttgg ccgccgtgcg cgcgtccgag gagcaactgg gcaggatcgc cgcgttctac
     2041 gacgggccga tcgaggagta cgtgcagcgg ccacgcgccg agctgggccg gatgaaccgc
     2101 gacttccacc tggccatcgt gcaggcctcg ggcaacggcc ggctgctgga cgaatggctg
     2161 cgcaaccgcg acttcggcat cacgtacaac atggccgtcc tcttcaccag ggacgaggtc
     2221 gtcacctgcg tggaaggcca tcagcgcatt gtcgaggcgc tgatgcgccg cgaccgtgag
     2281 agtgcggaga ggcacgcgag gatccatgtc gaggacgtcc aggccgcggc cagccgccgg
     2341 ctcgacgccc tgcagacgtc cgtcggactg tatctgtcct gagctgagaa gtcagggtgc
     2401 gcggcggagg tgggtgcgct gtccgtcgtg gtcgaggatg gtcaggatct cggccggacc
     2461 gtcgtgcgcg ccgaaggcgt gggggatcat cgtggcgaac tccgccgcct gaccggcctc
     2521 gaccaggatg gtgcgctccc ccagcagcag cacgacagtc cccgacagga cggtgaacca
     2581 gtccctgccg gggtggaccc ccagctcggc ggtgtcccgc cgcggcggcg gcttggtgag
     2641 acggatcttg gccacggtca tgccgtgcgg cccgggctcc cggctcagcg tccaggtggt
     2701 catcccccgc gcctcatcgc gctggggcct gatcaccaca tcgtcgtcgg tggccgactc
     2761 cacgagttga tcgagggtgg tctccagggc gcgggcgatc gcggtcagct ggtcgaggct
     2821 gatgcgccgg tgacccgtct cgatccggct cagggtggag gggctcaggt agcagcgggc
     2881 ggccaggtcg tcgagtgacc agccccgggc cgtacgcagt cccctgatcc gcatgcggac
     2941 cagaccgtcg agatccccgt cttgcttcat acgcaagagc ctatgccatg tcggcaagac
     3001 gggcgtaggg tccgagcatg gcaacccacc agcaccagga ccaccactcc gcagccggaa
     3061 ccgacgacat ggcgatggcc gagctcctgg acctagacgc ggaagtgctg cactcatacc
     3121 tgtccgagct gaccgcctgg atcggcgggt tcgccgccga cccggcccct cgccgcatcc
     3181 tcgatctcgg cagcggaacc ggtaccggca ccttcgccct cttggagcgc ttcgtccagg
     3241 ccgacgcgac cgccctggac atctccgcgc cactactgca ccacctcagg aacaaggctg
     3301 atgagctggg catggctgat cgagttcgta ccattcaggc ggatctggac gccacatggc
     3361 ccgatatcgc ccccgtcgac ctggtgtggg cgtccgcgtc cttgcaccac atggcagacc
     3421 ccgaccgcat gctcaccagc gtcttcgccg cactgcggcc cggcgggctc ctggtggcag
     3481 tcgagatgga ctccttcccg cgcttcctgc ccgaagacct cggcatcggc cgtcccggac
     3541 tcgaggcgcg ctgccatgcc gctatggccg aagaacacgc cgtccacgta ccgcatctcg
     3601 gctccgattg gggccctcgc ctgatcgtgg ccggcttcac catcgaggcc gaacggacct
     3661 tcgccgtcga tctgacgccc ccgcttcccg cctccgccgc ccgctacgcc caggcatccc
     3721 tgcggcgtct gcgatccggc ctgaaggacc ggctgagcgc cggcgacctg gccgcgctcg
     3781 acgcccttct cgacggcgac gggcccgagg gcatcctgcg ccgcggcgac ctccacgtcc
     3841 gcaccgcacg gaccgtgtgg gtggcacgcc gcccatgatg tggcctcata ccagctccta
     3901 acaggtcaaa tcgaccgcgg ccacagatgc gaaacggtga tgaaacagac tcttgagaca
     3961 ttggatccaa atttgtatcc tacgttgcaa gccgtacgca cgaccgtgaa cgcgtacggc
     4021 aggctcgaca tcgcggtgtc cacgcccggc atcaacatcc gcaagcggat ggccgcctac
     4081 actgaggagg agttcgaccg catcgtcggc ctgaacctca agggcacgtt cttcttcctc
     4141 caggagacca gcgcggtcat ggcggagcag ggcggaggca gcatcatcgc gtgctcgtcc
     4201 atgcgggcgc tgatggtcga gcccggctcg gcgtgtacgc ctccacgaag gcggccatcc
     4261 tgcagatggc gcgcggcctc gcctccgagg tcggcccgca gggggtccgg gtcaacacca
     4321 tcgcgcccgg ggtcatcgac acgccgctca cccggccgct gtgggacgac gtcaaggcca
     4381 gggacgccta cagcgcgcac accgtcttcg gcaggtgggg cagcgctgac gaggtcgcct
     4441 ccgcggtggc cttcctcgcc agtgacgcgg cctcgtacat caccgggacc aacctcgtcg
     4501 tcgacgcggg ctggaccgtc atcgacgacc gcttcgaccc gggacgctga ccggcgggat
     4561 atccggttgc cctggtcgcg aggccgctga caggatcgcc gccatgcctg ccttctccgc
     4621 gcacgacgga accgacctcg cctaccacgt gttcggagaa ggcgtcccgg tgatctgcct
     4681 gccgggcggc ccgatgcagg acaccgatta cctcggtgaa ctcggcggcc tgtcggcgca
     4741 tcgacagttg atcatggtgg accttcgggg caccggccgg tccgcgatac cggcggacgc
     4801 tgcctcctac cgctgcgacc ggctggtcga tgatgtcgag gcgctgcgcg aacacctcgg
     4861 ccttgaccgc ttcgacctgc tcgcgcactg cgccggcgcg aacctcgcgg cgctgtacgc
     4921 ggcccggcac ccggagcgcg tcggcaagct cgccctgatc actccgagca ccttcgccgt
     4981 cggcatcgcg cccaccggcg agtcccggct cgagatcgcg cggctgcgcg aggacgagcc
     5041 ctggttcccg gcggccttcg cggcccttga ggccatcgtg gccggcaacg ccactgacgg
     5101 cagccggcag gccatcgacc ccttcttcta cggccgatgg gacgcggcgg cacaagccca
     5161 ccacgccgcc cagaacggcc atcggaacga tgaagccgca gccgccttcg gcgccgaggg
     5221 cgcgtacgac ccggatgcca cccgcgcggc actctccgcg ttcagcgcgc cggtgctgct
     5281 gctcgccgga gaggtcgacc tgaactcgat tccgagcgcc gtggccgcat tcgccgagct
     5341 gttcccgaac gccgagttcg ccgttcaacc agcggcaggc cacttcccct ggaccgatga
     5401 cgccgaccgg ttcgtggcga cgaccgccac gttcctcggc tgaccttcta ccccggcacg
     5461 gcggcgccca gcacgagcga ggcgatggcg agcgccagaa agccgccggg aaaggccacg
     5521 ttgtagagca cgcgggcccg tacgtgggcg gcgaccgcgc cgacgaagaa cagcacgagg
     5581 ccggtcgcgg cggcgagacc gacgaaggga acaccgacca ggccgagcat gagcccggcc
     5641 gctccggcca gcttgagcgt ggcgagcagc ggcagccagg atggcgggac gcccacttcg
     5701 gcggcgttcg cgacgacgag cctggcccgt gcgaagtcgg ccacggcggc accgacgttg
     5761 acgacgatgg tcatgaccgc cacgacgaca taagtggtga acattcctct acgacgtatc
     5821 cacctacaag gggatgtgac atcggaacac cggcgggccg ggcaccataa ggtaggccat
     5881 cgacagggtt gcccacagga acccccgaat gccgacaccc cctccccctc tacggatcag
     5941 ccaggcaggc gcccgccggc tggtgctgtc ccgacagcaa ctggccggcc cccacctgcc
     6001 gggggacgcg gggagtctgc gcacgtcctg cggtcgctgc gctacgtgga gctggacccc
     6061 gtcagcgtgg tggccccgag ccatgacctc gtcctctgga gccgtctcgg cccgcgggca
     6121 ggcgcctatc tcccctgcct gtggtggcag gagcgatggc agttcgagta ctcggcccac
     6181 accgcggcca tcgtgctcac cgaggactac ccgatacacc gggtgacgat ggactccttc
     6241 cctccgacga accggtcgta caccagatcc tggatgggcg ccaacgaccg gcttcgcaag
     6301 cacgtgctgg atcgcctcgg cgaaggcgct cccctgcccc acctagtgag ctggtcgcga
     6361 gtatcaggga caccacatga gatggttgct gtttcaggtt ggctgtgcgg tggtgacggt
     6421 gcctggctgc tgaggtcggc tggagagatg gcagacagca ggctcgagcc ggcggcgtta
     6481 tccggctctt cgaacttgat cggggtctga ggtccagcct ggcccggggg gcttgagaga
     6541 gctcgtggct ctcggtgatc cttcttgttg tcgacgcaag aagatcacag cagagaagcc
     6601 acgagcatgg tcaacgatac gacgctgctg ctcggcctgg acggggtggc cgtcacgaag
     6661 gtcgtcgccg caggtgacgg agcacaggat ggacccgtcg tgcacctgtc caccgcagat
     6721 gagcgagcca gatgctgccc gcagtgtggg gttgccgcgg tccggatgaa ggaatgggtg
     6781 accacccgcc cgcgtgacct gccgatgggc gggcggcact gccggctgcg ctggcgtaaa
     6841 cgccgctggt ggtgtgacca gcagaggtgc ccgcgccgga cgttcaccga gcaggtgccg
     6901 cagatccccg cacgctcccg gctgacccgg cgattacgcc aggccacggg tgccgccgtc
     6961 ggtgacggtg ggcgaacggt gatccagtca gcgcgtgatc accaggtgtc gtggccgatc
     7021 gtttgcgcgg ccttcaccga gcatgcccgt caggtgctgc ccgtccagcc tgagcccgtc
     7081 tcggtgctgg gcatcgatga gatccgccgg gggcgccccc actgggtcct ggacgaggcc
     7141 accggcacct ggagcacggc ggtggatcgc tggcacaccg gcttcgtgga cctgtctggc
     7201 gatcaggggc tgctcggcca ggtcgagggc cgcaccatcg ccgccgtcac cggctggctc
     7261 aaccagcgca gccaggcctg gcgagggcag gtggccttcg tcgcgatcga catgtgcacc
     7321 atcttcaaat ccgccgtgcg caccgcgcta ccgcgggccc gcctggtcat cgaccacttc
     7381 cacgtggtgc aactggccaa ccaggccctc accgaggtcc gccgccgcgt caccgtccag
     7441 attcgcggcc ggcgcggacg caagggcaac cgcgagtggg aactacgcaa ccggctcacc
     7501 cgctccgccg cccggatgca cgcctgccag ctggatccga tggtcgatga cctgcacgcg
     7561 ctcggccgca tcggcacgcc gatcctggcc gcgtggaacg ccaaggaaga cctgctggac
     7621 ctggcccgca cccaccccga tcggaccgtc atcgccgacc ggctgttccg tttctacgac
     7681 cgctgcgcag cctctggcct gcccgaactc gaacgactgg ccaccacgat cgacacctgg
     7741 tggccggaaa ttctcacctt catccagacc ggcatcacta acgccggctc cgaaggcacc
     7801 aaccgcgtca tcaagaccgt cgcccgcgac gcctacggct tccgcaaccc ggaaaaccaa
     7861 cggttacgca cccgctgcgc caccaccagg aaaggccgcg gatgcctcaa ccccgcctaa
     7921 gttcgaagag cccgttatcc gaggaagagc ggcggacgct ggtgggctgg gtcaggcgtc
     7981 gctcgactgc tcaagggctg gcgatgcggg ctcggatcgt gctggcctgt gccgagggcg
     8041 gcggcaacgt ggcggtggcg gcccggcatg ccccgcacca cccccgatgc ccaagtggag
     8101 gaggtggtga tacacaccct ggaagagatg ccggccggat ccaaccggcg caccaaacga
     8161 cttgtcatgt agccctctga ccggagttga gacgacgccg ggtcgaacca aacttccaga
     8221 cagcacgatc aacatctcca ccgcttatct tgcagactat ggtcgatgcc attcgctgca
     8281 actgctatac gattgacgct gtacgcacct tacgagttat cacctttcgc caactataaa
     8341 gcagagtccc atgaaatagt ccgagaaaca gaactgctat cgttgcctga agttcggtta
     8401 acacgatccc gagagcctct ccatagatgg cgacgaccag caaaaaggcc cccacggcca
     8461 ctgcgggaat ctcggccaca ctaaatatga acagtattct tctgatctcg gagttcattc
     8521 tgcgaagggc aagcagattc cacgctatgt agagaacaat agtcatagtc caatggaaaa
     8581 ccgttctact acttagggga agtggacttg tgggaggcag tcgaaggcca tgtattacgc
     8641 caacatagtt agccactgta atcagatcga tgaggaccag gtcgtcctcg aatgtcaaga
     8701 gggcggcgcg ggacgctttc caatcctgcc tccaagctcc aatcatcagc gccaacagtg
     8761 ccgccgaaac ccaatcatga atatcatgca aaccaaaaac tgcgaacgcc caaggcacca
     8821 cataggctag gtcgcacagc agaactcggt tactctgcag cgacgagtgt ggatcgatag
     8881 ctaaactccc atcatctgcg caagagaagg gccgccacca gcaaggagca atttactgcg
     8941 tggccggcga cctcgtacgt aggggaccat ttcgccaccc ccaccacttc gacaggcttc
     9001 tcatgggcat acgaaacgat tctcgcggaa tccagcagga agtacagcgg aatacggaac
     9061 ccgtcatcct cgaggatccc agtaaaacag ttgaacccgt agattttgtg ggtgtgctgg
     9121 acctccacag catcaggcga gaaggggtcg cgcgcctttg ttcccaactc gggcagccgg
     9181 agaacgccat tgacgctcac cacatccggc ggcgccaccc gtctctcgct cacctccttg
     9241 gcgaagcccc ggacacgaag gtccttatcg cggatcttcg gataagcaaa ggagaagata
     9301 tcttcaggaa agaggtcggc cagtcgcgtc tcggcactgt tttcacttcc gagcccaaat
     9361 ctagtcgtga cgagccaatt gatcccgcca gccaagtttt cactgttctt ggtcgccagc
     9421 gaggatccca caagcttgac cgcaacgggt aggatgagct ccctctccac atacaccaaa
     9481 gtgttaggca cgtcagtaga catggggatg ccaaccgccc tttcatggtg tactcgcgtg
     9541 aaaagtgatg gcgcttttac gccctgcgca cgagtatccc cccaagacgt gtcaatctgc
     9601 cacctaatct ccaattgaaa gatctcaaga agattaagtc ggacattggt caacttttgt
     9661 cgcaagtcgc aataattcct cccggatcca cgggatatcg gagggcctat actccggacg
     9721 ccaaccatga tcttgctgcg tgggtgcggg gaagcagggt tcggccatcg cgtaatcatc
     9781 agttgaatgt gaggacaacg aagatcgaca gttgtcgcga gccgcggtcg tcgcgaaccc
     9841 aacgagtgcc ttagacgatg ttcgtgacgt tgcgcagccg tagcgcgcgc acggccactg
     9901 atttcggaag acagctacct gtcagcgaat tgcaagaccc gtcagcgacc ttcgtgtcga
     9961 gcgcctccac cagacggcgc cgaaatcggg gggtagtgcc gtgggggctg atgcgaccat
    10021 tctgcgcgac ctcgtgaccg ccgagctggc gcggtccggc gaggcgggct ggtcggtcga
    10081 ggcgtccgat ttctggtgca gggtcactcc tgatggctat ccgatgcctg agcagggatg
    10141 gaagctgcat gtctccgcga cgatgctgtc ggcgcccttc gtcctcgccc aggtcgcccg
    10201 cgtgctcatc gaggcggggt gcgccttcaa gttccccgcc gagctgggcg cctactggga
    10261 gttgctctcg ccgcactgcg cgagggcgca ggcgggcaag ttcgtcacgg cctacccggc
    10321 cgacgatgcc gagtcgatac ggctggcggc cctccttgac gaggcgacca gggggctgcc
    10381 ggggccggtg atcctctccg accggcccta ccgcgcgggc ggcatcgtcc actaccgcta
    10441 cggggccttc tccgggcacc ggactctggg caacgacggg ttctacgagg tacggctgcg
    10501 cgctccgggc ggagagctgg tccgcgacca gcggacggcc gccttcaccc cgccgagctt
    10561 cgccgcctcg ccctttcagc ggctcggctt tcaacggctc ggcgggccgt cgaaggcgtc
    10621 ggcggtcatg ctcaacgacc ggttcgtggt gcgggaggcg atcagacacg cgaacagggg
    10681 cggcgtgtac ctcgccgaag acacgaagac cggacgcgag gtcatcatca aggagggtcg
    10741 cccgcacgcc tcctccgacc tcagcggccg agacgccaga gtccggctgg cggcggaacg
    10801 cgccgctctc gacgacctcg ccgccaccga tggcgtgccc gccgtcgtcg actacttcga
    10861 gcagggcggc cacgcgttcc tcgcggagga gctggtgccg ggccgcaccg cgcatcgctg
    10921 gtcggaggcg cacgcgacgc ctctcggccc ggacggcttc ggatgcgcgg tcgaggaggt
    10981 cgtaccggtc gtctcgcgcc tggtcggcct gctgcgggag gtgcatcgcc acggctacgt
    11041 cttccgcgat ctgtcgcccg gcaacgtcat gatcctgccg gacggccagg tccggctcgt
    11101 cgacctcgag tacgcggcca agcagggcac caccgtcatg atcggcggca cccccggcta
    11161 tctggcgccg gaactcgccc cgcacaccgg cgccttccac caggctcccc cggcgacggc
    11221 ggatctctac agcctcggag cgctgaccta cttcctcgcg gtcggcgccg atctcggcct
    11281 ggcggaagac ctctcggaag acgaggcggc gggcctggcg tggggcacgc gcaccgccga
    11341 ccacctggcc agggtcgccg agagcaaccc caccctggcg gcgctgcggc cgatggtggc
    11401 gggcctgctc gccgagccgg atgaccgctg gacactcgac gcctgcacac ggttcctggc
    11461 cgacctcgga cagcccgacg tgcgaccagc tccgcaccct cgggtgaccg cggacgacct
    11521 catctccgac gggctcgcct ggctggccga gaccatggac gaccgccccg actgcccgtc
    11581 accctggccc aacatcacct acgggctcga agccgatccc tgctcggtga gcgccggcgc
    11641 tgcgggcatc ctcgcggtcc tcccacccga acagaccggc gcggtctcgc gctggctccg
    11701 ccgacgcctc gccgaagagg atgtctggcc tcccggcctg tacgccgggc gatccggtgc
    11761 cctctgggcg ttgtacgagg cggcggccga cgaggagtcg agggacttcg cggtacgggc
    11821 cgcgtaccgg ctgccgaccg accatcccag ccccgacgtc acccacggcc tggccggatg
    11881 cgcgatggcc accctgcgcc tcgccatccg cgcggacgac cccgcgctgc gcgagcgggc
    11941 cacggagatg ctccagaacc tgcacgacgc gcggtcctca tacgaagggc gcccgcaatg
    12001 gccgacacag gcgaccctcg actccagcct cgccggcacc aaccacttcg gcttcgccca
    12061 cggcctggcc ggagtcggca ccgcgttgct ctatggaggc gtcgccctcg gcagggcgga
    12121 ctggatggag accgtacgcg aggtggccca cgccctctac gagcacgccg acgtcgacgg
    12181 ggacacggcc tggtggccgt tcaggcgcga tgagcgcgag tccgtacggc cccgccgtcc
    12241 ccactggtgc agcggttcgt cgggcgtcgg ctccttcctg atccgctatt ggaacgcgac
    12301 gaacgatccg gccgccctgg aactcgccga acacgcggcg atcgccgtac accggactcg
    12361 gtggcagtcg ggctcggcgc tctgccacgg cctgcccggt gagggcgact tccttctcga
    12421 catggcccgg ttcaccgcgg acgagcggta ccaccgatgg gcggaggatc tggcagcgtg
    12481 cctgagcgcg cgggccgtca ggcacgcggg ccggctgcac gtacccgatc gcctgggccg
    12541 gaccgtgccg acctacctcg gcgggaccgc gggcgtcctc gccttcctgc tgcgcctgcg
    12601 tcacggacat ccgcgcctgt ggatgctcga cgacgtcatc ggcgctcccc atgatctcgc
    12661 cgtgccccga gcacggcgac gccaggagga acggaaatca gagagggggg agaaacatgt
    12721 ctttcgacgt tcaggacctg cagaacctgc aggagcgtga gccgagcacc acggagtcgg
    12781 cgctgctgag caactgcctc aagcacccgg gttgcaccga caccaactga tgacggaacg
    12841 gcgtgcggca ggcatgggcc gcacgccgtt tcagagctcc gagggcctct gagagggcgg
    12901 cagacgtgac gactcgcagg atcatccggc tgttcacgcc gtatcgccgt gccgtcctgc
    12961 tcgtcgtgct gctggtcgcg atcttctccg cgctgaacgc cgccatcccg ctgctgaccc
    13021 aggtcgtctt cgaccgcgcc ctgttcggca aggacggtcc acggcccgac ctgctggcgc
    13081 tgatcgccgc tctggcggcg gtcacggcgg ccggggcggc gggcgtcgat ctggcccaga
    13141 cgtgggtctc ggcccgcatg gcccagcggg tcatccactc gctgcgtacg cggctgttcg
    13201 gtcacctgca gcggatgccg ctcggcttct tcgccgccgc caggagcggc gagatccagt
    13261 cgcggctggc caacgacacg aaccagatcg aggacgcgat caaggacacg ctgcccagcc
    13321 tgctcggaag tctcctcgcg ttcctgttcg cgttgggggc gatgttctcg ctgtcctggc
    13381 cgctcgcgag cgtcaccctg tgcctggcgc cggccatcct gtgggtctcc gcccgttcgg
    13441 gacgcgcgct caaggtcctg tctgtcgccg gccagcgggc ccgcgcggag atcgcctcca
    13501 tcgccgccga acgcctctcg ctgggcggca tcacgctcgc ccgggtgcac ggacgcgaca
    13561 gccacgaggc cgcggtgttc ggggcggaga gcgaacggct ggcccggctg ggggtccgcg
    13621 ccgggctggc cgctcagtcg gtgctgagcg cggggcacat cttcttcgta ctgacgcctt
    13681 acatcgtgtt cgtcgcggcc gggctcatgg acgggatcac gcccggcacg ctcatcgcgt
    13741 tcgtggtgct gcagtcgagg ctctatcagc cgctctggca gatcctgcac atctccaccg
    13801 agttccgtac cgcccaggcg gccttcgaga gggtcttcga gtacctggac ctgccaccgg
    13861 gaccgccgcc cgccgtacgc ggcggaggag cgggcgaagt gcgcgtcgcg ggggcctcct
    13921 acgcctacgc ggggccggag ggcgaggcac gctgggcgct ccgcgaggtg accctcgacc
    13981 tgcccgccgc ctccgcgaca ctgatcgtcg gcccgaacgg atcgggcaag acgaccctcg
    14041 gttacctgct cgccgggctg tacgagccgg cggaggggac ggtacggatc gacggccgcg
    14101 tctgcctggc tccgcaggaa gcgttgctgt tccagggctc catcgccgag aacctccgct
    14161 acgccgcccc cgaggccggc ctggacgacc tggtcgcggc ctgcacgacg accaggatgc
    14221 acgaccggat catggctctg cccgacggct acgactccgt ggtcggtgag cggggtgcgc
    14281 tgttctccgg tggtgaacgc cagcgcatcg ccctggcccg cgcgctcctg agcgacgcgc
    14341 ccgtcctggt cctggacgag gcgacctccg cactcgaccc gctgacggaa cgcgaggtca
    14401 tccacgcggt tctgctgcgg cgcaggggga tgacgacggt gatgatcacc caccggttcg
    14461 gcggcctgga cgcgttcgac accgtcgtcg tcctggatga agggcgcgtc gtggagcggg
    14521 gcgcccaccc cgaactactg ggcaaccggc acggcctgta cgcacggatg gtccgcgccc
    14581 aggccgtcca gcggggcgat ccagccgacg gcgagggtgc cgtaatagat ctgccgtcgt
    14641 ccctgctctc caccggcccg gcctgcagat gctcgggatc ggtgcggcag ctgagcatgg
    14701 atggccagat gtcgcgaatc gactacgaag cgtgatcgat tccggtacgg tcgcctcgtc
    14761 gccggtcgaa ccaactggca gacagccgat gttgaccggg tggtgtactg caccgcccgc
    14821 atcgatggcg cggacaaccc tgatggccag cgtgatcaga gcgtctacat caacgccctg
    14881 cgggccagcg gcagcgtcga tcacatcgag ttcggctact gtgtctcccg ggtgaagtac
    14941 gcgccgctcg ctgtacggga ccgggcgggc cggcccgtgc tcgcgcgtcc cacgtggccg
    15001 atccaggtgt gtgactcggc aggcgcgtcg gtcccaggcg cgagcttcat ggtctcctac
    15061 gcctatcgcg aggagaaggg ttctgacgtc aacgttgcct cgcaccttct ccttgatgtc
    15121 ttcaagggtg tagttgacgc ggccgtcgtc atctccaacg acagtgacct gcgctttccc
    15181 atcgagcagg tccggcagca cgtccctgtt ggcctggtca accccagcgg caactacctc
    15241 gcgggagcgc tgcgcggcca ggccgcagat ggggttggac ggcactggtg gtatcagctg
    15301 accgcaggtg atctgatcaa gtgccagctc ccttcgaccg tcagcgcgta tacacgccca
    15361 ccgggctggt gacggcaatc gccccgcgcc tgtgaagctc gcctgctatt ctggagacat
    15421 ataccacccg gctccttgtg ggccgggttt tcttatgtcc ggccgggctc cgcgctgcgc
    15481 gcccagagcg ccaccgccgg ggtctcccga tggcccgcca aaggtctgct cgacctgctg
    15541 cttgccggtc cctcgatctt ccgggctctg ggacatcgca ggtcattcac cgcaggttgc
    15601 gcgccgggca gccgcggcga gtatgtctga tagctatggg acaaaagacg ttttatccgc
    15661 cgattgagcc gtacgagacc gggatgctcg aggtgggcga cgggaacgag atctactggg
    15721 aggtctgcgg caaccccgac ggcaaacctg tcgtctttct tcacggcggt ccgggcggtg
    15781 ggttgctgcc ggcgcaacgg cggttcttcg accccgaggc atacaagatc gtgctgttcg
    15841 agcagcgcaa ctgcgggcgc agtcgaccgc atgcggcgga ccccggggtg tcgctggagg
    15901 ccaacacgac ctggcacctc gtggcggaca tcgagcggct caggcagtgg ctcggcatcg
    15961 agcgctggca ggtgttcggc gggtcgtggg ggtcgacgct ggcgctggcc tacgcgcggc
    16021 ggcacccgga gcgggtgagc gagctggtgc tgcgcggtgt ctacttggcg accgaggccg
    16081 acaacgtgtg ggcgttcacc ggcaccgggg cggcccggct gttcccgcgg gagtgggcgg
    16141 cctttcgcga cttcatcccg gaggcggagc gggacgactt ggtcgccgcc taccatcgca
    16201 ggctgtccga cccggacccg gaggtacacc tcccggccgc gcgggcgtgg gcggcctggg
    16261 agctgtcggc gaacacgctg ctccccgccg ccccaccgcc cctcgacgac cgggagctgg
    16321 tgagcttctc gcgcatcgag gcgcactact tcagccaggg gtgtttcctg aaggacgggg
    16381 aactgctcga cgtggccgcg atccggcaca tcccgtgcgt gatcgtgaac ggccgctatg
    16441 acatgaagac gccgccggac gcggcgtggg acctgcagct cgcctggccg gaggcggagc
    16501 tgcggatcgt cgaggacgcc ggccacgcgg gcgccgagcc cggcacgctg cacgagctca
    16561 tcacggccac cgacggttac cggcaccttt agttatagac gatcgctttt cgtgacagga
    16621 gaattactgc cagcacgcac gaacgaggag ggccccatgg cgttccccat catgaagctg
    16681 gcggccgctc tgatgttcgc ctgtccgagc cccgtccccg tcgcccccgc cggcaccgcg
    16741 ctgctccagt cgggtgagat ccgtttccac accatcaacg aggccaagga caccgagacc
    16801 atcgtcacgg tgaccgtccg cgaccgtagg gggcagacca tcgccctcct gaccggcgtt
    16861 ctcggccaat gggccgagaa cgcctggtcg gcccgcatcc cgctgaacgt catcagcccg
    16921 cccggagacc tggcgcggct gtggggcggg acgatcaatg tccggatcga cccgaagggc
    16981 gaggacgcct gggccttcac cttccacacg tacctgcgct tctccaacgg ggagacggcc
    17041 gacgtctacc agcggcagct cgcggtcgtg aacgagggcc gccgcgactg gaccacgatc
    17101 atccgatgac gagcgacttg ccgaaagtgc gggccgccgg ccggattttg ctccactctt
    17161 gatcggtgac cgtcggccag gtcaccaaga ggctcccggg cccgccccag aggcgggccc
    17221 gggttatttc acgagacctt gtcgggccgc tccgagatgc ggatggcgtt gacgatcgtc
    17281 ttgccctccc gcgtggcgaa gcggacgttg agctggccgt cggtgacctt caccgtgtac
    17341 tgcctgctga cggccgtgta cgtgcccgcc tccagcgcca ggtcgagcgc cgggatcgcg
    17401 agctggccct cgacgagcac gtcgaagacc cggcggccga tctgcgtcga cttgacgtcg
    17461 gcgaagtcca gctcgacggt gtacgtcccg gccggcacgt tgtcgaagcg gtactccagc
    17521 atcccctcgc gagccgtctt gaacagcgcc tggtcgtcgg tgcccttgat ggtcttggac
    17581 gaggtgctcg tactggtcga ggtggcgatg tacccgtaac cgcccgcggt gtacttcttg
    17641 tcgggcgtcc aggcgtcacc cgcggtgtcg gtcacggcct tggtgccgcc ggcctccacg
    17701 gccacctgga gcttgggcac cacgaccgtc accgcgatct cgatgaccgg ctgccgcccg
    17761 ctggccgact tcacgatcag cttgcccgag cggagcgtgc ccggcaggac gccggcgctg
    17821 gacaccgtga ccttcagtgt caccgcctgc cccttggcga ggtcgcccgc cgtcggcgtg
    17881 acgccgatcc agccctgtgc cggatcggtg gtgacggtgt acgccgtggg cgagccgagg
    17941 ttggtcagct ccatcgtgcg ggttcgggtg gcgttcgtgg gcagcaccac ggtcagctcg
    18001 ctcaccgagg ggctgacccg gccggtgatc agcgcggtgt cgatcctggt gaccgtcgtc
    18061 ggggcgatcg tcacggtctt ggtgaacgtg ccgtaatgct ccttcgacac ctgcacctcg
    18121 tagtcgccgg ccaggacctg cccgtagaag gcgccgtcct caccggtggt gtaggtggcc
    18181 acgtcgccca ccttcaccgt cgcgcccgcc agcggcttgc cgtcgttggc gtcggtgacg
    18241 gtgcccgtca ccaggccgtg cctgctagcg atgaacgtca gactctgccc gttggccagt
    18301 gcgacctcct cgtaggagta ctggaacgcg tcggtgcccg ccgcgttctc gaccccgacc
    18361 gtcgcactgg tgcccttgtc gcgctcgctc tcgatgtcct tgtagcggta gctcatcgtc
    18421 ccgtcctcgc ccagcagcgc cgcgaacgag acgcgctggt cggtggccga gtagaacttc
    18481 acgttgcgcc actcgaccac gaactggcgg tgcggcgccg tacccgtgac gccggtgtag
    18541 ataccgctgt cggcgtccac caccaggtcg tcccagtacg ggtagacggc gttgttgggc
    18601 gtagccgtgc tgggcagccg gccgttgctg ccggtgacga tcttgtcggt ggcgaaggtg
    18661 gcgaacccgt tggtgctgat ccacgcccgg ctctgcccca cgccgtagaa cgggaccggg
    18721 aacggcaggt tcacctgctg cgcctcgtcg tcgcccgtga gcgcgagctt ctcggtgccc
    18781 gcgacgtatg gctcagcggc gctccggcag gtgtagccga agttgtcgcc acgcaacggc
    18841 agctcgatgt ccttggtcac gtccccggcc accgtgacgg acgccgtggc gccgctggag
    18901 cagcgggaga ctggggtgat cttgaggtcg taggtgccgt tcggcagtga cagccggtag
    18961 cggcccgcgg cgtcggtgac cgcgctgacg ggcgtgccga ccgcctcgat cttggcgccc
    19021 ggctccggcg tgcccgccgt gctgaccgtg ccggtcacca cgcccgcggc ctgcagggtc
    19081 atcgccacgt cggccgtggt gctctgctcg gccgtgatcg tcgccgtcgc ggtgcccttg
    19141 tcgtagccga acttctccgc ggcgatctgg tagtcgcccg gcagcaggcg cgggatggcg
    19201 tacgtcccgt ccgaccccgt gatcaccgta cggctcagcg gcccggacag gttgaccgtg
    19261 gcaccggaca ccgggctgcc cccggcggtc accgtgccct tgaggtcgcc gagacccccg
    19321 cgcggcgcgg cctgcaccgc ggcgaaggcg tccaggcggc cctcgcccca gacgttgttg
    19381 tcggcggcgg tgccaccgca actggtgtcg ttgacgtcga tcgcggtgct gtcgagcagc
    19441 ggccgggtgg cggccacgtc accctgcagc ccgggagacg ccgaccagat cagcgccacc
    19501 gtcgccgcca ggtgcggcga ggccatcgac gtgcccgtgt agctgtcgta gccgttgccg
    19561 ggcaccgagg agcggacgtt cacggcgggg gcggcgaggt tcggcttgat ctcgccgttc
    19621 tcgccctcgc ccttgctgga gcgggcgtac agaacattgt tgatgtcgaa gccgcccgcg
    19681 ctgtagctga tcgcgtactg tccgggcgac ccgctggtac ggcaggcggg cccctcgttg
    19741 ccgttggcga aggccgggaa gatgccggcg gcgatccacg cctcgacggt ctccttgtac
    19801 caggggtcga agccggcgcc gccccaggag ttgttgacga tgtcgggggc caggtcgggg
    19861 cgcgggttgg cgccgttcag gtcggtcggg gcgagcatcc actggcccgc ggcgagcagc
    19921 gaggcgtcgg tgcaggtgtt gacctcgcag cccttggcgg cgatccactt ggcgcccggc
    19981 gcgaccccga tgccgttggc gccgaccatg gtgcccatga cgtgcgtgcc gtgcccgagg
    20041 ttgtcacagg gcaccgcgct cgggcagatg tgcgcggggt cgaaccagtt gtagttgtgg
    20101 tcgagggagc cgtccgggct cctgccacgg taggccgcgg ccagctcggg gtggtcgaac
    20161 tgggcgccgc tgtcgatggt gccgaccacg atgccttcgc cgcggtcggt taactcgttc
    20221 cagacgcgcg gggcgttgat ccggtcgatg ttccactcga cggcgttgac cttcgcctcg
    20281 gccttaccgg ggtccggctt cggcagcgac acggtccgta ccgggtcgat gcgctccacg
    20341 tccgccaggg cggcgatctc ggccgccagc ttggcgtcgg cggtcactct gacggcgttg
    20401 acgatccagt acggggtgta gtcggcctgg tgggactcca ggagtttccg cagggccgcc
    20461 tgcgaggtgt cggccttggc agtcttggcc tcgaagacct gctcggcctt gtcgtccttg
    20521 gtcgtggccc ggcgggcgcc gctgaggtcg gcggtgccct tcatgcgtac ccagaaggtg
    20581 gcctttccgt cggcggccag gtcggcctgg acggatttgt tgatcttgcc cgggtcgggc
    20641 gcggcttggg ccacgccctg agggaggatg agggtgacag cggcggcgac cgcgatcaat
    20701 atcgcacgcc aatggggggt ggacggcaca cgctctcctt cacgccatgg gagtagagct
    20761 gatctttacg cctatgggga gaacagtgga gagaacgtgt cagctttgca agggtctgac
    20821 cgcaacaaga catgacatgt catgaaatgt aatctcgacg actcatcgtc ggaggtgctc
    20881 tagacctggt tcggcagcgc cccgccgtag cgcctgtcgc gcttggcgta gatctcgcac
    20941 gcctcccaca ggtcgcggcg gtcgaagtcc ggccagagcc ggtcgaggaa caccatctcg
    21001 gcgtaggccg actgccacag caggaagttg gagaaccgct gctcccccga cgaccgcacg
    21061 aacaggtcga cctccgggat ctccggctcg tcgagatagc gggcgaacac cttctcgttg
    21121 accttcgacg gcttgacccg gcccgccgcg atgtcgttcg ccagccgcag cgcggcctcg
    21181 acgatctccg cctggccgcc gtagttgacg cagaactgca acgtcagctt gcggttgcgc
    21241 tcggtcagct cctcggcgct ctgcaactcg gagatcacgc tcttccacag ccggcccggc
    21301 ttgcccgccc agcgcacccg tacgcccatc gcgtgcaact cgtcgcgacg gcggcggatg
    21361 acgtcgcggt tgaagcccat gaggaagcgg acctcgtcgg gcgagcgctt ccagttctcc
    21421 gtggagaagg cgtatgccga caggtaggga atgcccagct ccagcgcgcc ctcgatgacg
    21481 tcgaacaacg acgcctcgcc cgccttgtgc ccctcggtgc gtggcagccc gcgggccttg
    21541 gcccagcggc cgttgccgtc catgatgatg gccacatgtt tgggcaccag gtcacgcggg
    21601 atcggcggcg ggaccgcgcc ggacgggtgc ggggtcggtg gtcggacgtt cacacgggct
    21661 ccctctctac gtgtcggaga gagcgtattc cgtgttcgag gtgccattgc agatatgcgg
    21721 cgaccaggcc gctgcactcg ccgcgatgcc gcgcctgtga cgcgtcggcc gcggcccagt
    21781 cgccgcgcag cagcgcggtc atgagcccga tcgtctcccc cgcgggcacc accgatccgg
    21841 ccggtttgca cgccccgcac accacgccac ctgccacgat ggcgaacgcc ctgatcgccg
    21901 gggcccggca cctggcgcac gcgtccagcg cgggggcgta gccggcgacc gccagcgaac
    21961 gcaggaagta ggcgtcgagc accagcctgg cctcgtgctc gccgtcggcc agcgtgcgca
    22021 gcccgcccac cagcagcagg aactgccgca gcgccggctc cttctcgccg tgcgtcagcc
    22081 ggtcggcggt ctccagcatc gccgtgcccg cggtgtagcg ggggtagtcg atcgccaggg
    22141 cctcgccgta gggcctgatg gtctccgcct gcgtgacgac gtcgagcgta cggccggtgt
    22201 gaagctgcag gtcgacgtgg gtgaacggct ccagcctggc cccgaagcgc gaggtggtgc
    22261 ggcgcacgcc cttcgcgacc gcccggacct tgccggtgcg cttggccagg atggtgacga
    22321 tgcggtcggc ctcgccgagc ttctgcgtac gcagaatgac gccctcgtca cgatagagac
    22381 tcactcgcct atcctatggc gcgcgaaggt catgctcggc tggagcggct tcgcggacct
    22441 cggatggagc gactttgtgg aaccctcact agactttgac gtccgtcccc gctctacccg
    22501 ttgttcaacc ccccgcaacc gcctcgaaag ggagtcatga cccgcgtggt cctgctgggc
    22561 tcttcgcccg gccctgacac cgctccgacc ggcctgaggc tggccgcgct gcctggcaat
    22621 cccaccgtgg ccgaacggct gcgcagccag atcctctccc tggatccgca gccggccatg
    22681 atcgagcccg gcgacctggc caccgctctg cgcgcgctgg ccgatgtcgc cgagtccgca
    22741 acggagaacc tgttcctgat
//
