LOCUS       NZ_JAHFZZ010000006     24382 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Nonomuraea sp. NEAU-A123 Scaffold6, whole genome shotgun sequence.
ACCESSION   NZ_JAHFZZ010000006
VERSION     NZ_JAHFZZ010000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nonomuraea sp. NEAU-A123
  ORGANISM  Nonomuraea sp. NEAU-A123
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 660533)
  AUTHORS   Zhang,L. and Zhao,J.
  TITLE     Nonomuraea triticisoli sp. nov., a novel actinobacterium isolated
            from rhizospheric soil of wheat in Langfang, Hebei Province, China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 660533)
  AUTHORS   Zhang,L. and Zhao,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2021) College of Life Sciences, Northeast
            Agricultural University, Changjiang Road No. 600, Xiangfang
            District, Harbin, Heilongjiang Province 150036, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018603905.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 04:26:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,983
            CDSs (total)                      :: 11,901
            Genes (coding)                    :: 11,761
            CDSs (with protein)               :: 11,761
            Genes (RNA)                       :: 82
            rRNAs                             :: 5, 3, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 2, 3 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 140
            CDSs (without protein)            :: 140
            Pseudo Genes (ambiguous residues) :: 0 of 140
            Pseudo Genes (frameshifted)       :: 28 of 140
            Pseudo Genes (incomplete)         :: 121 of 140
            Pseudo Genes (internal stop)      :: 3 of 140
            Pseudo Genes (multiple problems)  :: 12 of 140
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:52:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 493989
            Orig. end                         :: 518371
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHFZZ010000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24382
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24382
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24382
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14382](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14382
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    complement(641..654)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.13"
                     /tool="antismash"
     misc_feature    993..1008
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.14"
                     /tool="antismash"
     gene            complement(1144..1416)
                     /locus_tag="KLK06_RS21390"
                     /old_locus_tag="KLK06_21380"
     CDS             complement(1144..1416)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS21390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_21380"
                     /product="hypothetical protein"
                     /protein_id="WP_214637288.1"
                     /transl_table=11
                     /translation="MNSPAWLWPPFSEPLRLRLPLQRPDTAPRPVTRRADRERSAHEEL
                     LAQLALLDAQLRKVADAIHRGDEQALRDQGRFLRDRFGGSDLDLD"
     gene            complement(1457..2215)
                     /locus_tag="KLK06_RS21395"
                     /old_locus_tag="KLK06_21385"
     CDS             complement(1457..2215)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016143.5"
                     /locus_tag="KLK06_RS21395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21385"
                     /product="neutral zinc metallopeptidase"
                     /protein_id="WP_214637289.1"
                     /transl_table=11
                     /translation="MRILAAALVTFLSLTGTAHAAPTPDPFTKNPLYKTGKLPAQTCEE
                     PDVNQDHDAIRLYVEAITACQEKAWSTQVTKAGFRYQKAKVVVKYGDRIKTACGVYHPD
                     DVYSLYCIPNKTIYLMLTDYGLRDELDSPGILESLSIGYGYHAQNMVGIVDQEYRAVKK
                     LPKAKALALTTKGSLQSICLAGAFIGSVWDSLGHSRAHGSEFFISRHAVEGSYKGFGTA
                     KNRVYWQRRGFDAASPSACNTYTAPASKVT"
     misc_feature    complement(2180..2182)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2260..2271)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.08"
                     /tool="antismash"
     misc_feature    2300..2314
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.99"
                     /tool="antismash"
     gene            2356..3684
                     /locus_tag="KLK06_RS21400"
                     /old_locus_tag="KLK06_21390"
     CDS             2356..3684
                     /EC_number="3.4.11.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013592.5"
                     /locus_tag="KLK06_RS21400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21390"
                     /product="M1 family metallopeptidase"
                     /protein_id="WP_214637290.1"
                     /transl_table=11
                     /translation="MIRKTLTFCAIAALLIGLPTAARAADATRTPGSPTYTVTLTSNAS
                     GTTWTGHESVSFTNLSADPLNEVYLRLWDNYHGSCPSTPITVTNVSGGTASALSVACTA
                     LKITLPAPLAQGQNGSVGFDLSIVVPSGADRFGHDGAYNFIGNALPVLAVRDGAGWHLD
                     PYTNNGESFYQLASDYRVTLDHPSSLLVPATGTSVDTPGSAGRTITTATATHVREFAWG
                     AGAFTKTTGTTSTGVTVNVYRVSGISAASAASMMTTATGSLVAHAGRFGAYPYGEVDIV
                     LDNNFWFGGMEYPGFVLDLVSSTALAHELAHQWWYGIVGDDEYNTPWLDESFADYATDL
                     YRGITGTNCWNSVVWASSAERISNSMAYWDAHSSRYGTVVYTYGKCALHDLRRLIGTSA
                     MQTLLHDYAASHWYGISTVADFKAAAQAATTVDLSSFWTTHRI"
     misc_feature    2395..2397
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2533..2535
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3693..4220)
                     /locus_tag="KLK06_RS21405"
                     /old_locus_tag="KLK06_21395"
     CDS             complement(3693..4220)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013053.5"
                     /locus_tag="KLK06_RS21405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21395"
                     /product="cysteine hydrolase family protein"
                     /protein_id="WP_214637291.1"
                     /transl_table=11
                     /translation="MDVQRVVVDRYPDPAYLPRLREAIGAARAGGVPVIYVVVGFRPGY
                     PEISVRNKMFGRLAGTTPLVGGDQASQIHPDVAPEPGDVLVTKRRVSAFAGSDLDMVLR
                     AGDVDHLVLTGIATSGVVLSTVRQAADLDFGLTVLADGCLDADPEVHRVLTEKVFPHQA
                     DVTTVAGWAATR"
     gene            4401..5024
                     /locus_tag="KLK06_RS21410"
                     /old_locus_tag="KLK06_21400"
     CDS             4401..5024
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF037150.5"
                     /locus_tag="KLK06_RS21410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21400"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_214637292.1"
                     /transl_table=11
                     /translation="MATRKTDGSPDDAAAGQPAGGRRRRDAAATREALLQAARDRFMRL
                     GYDRTTLRDVAADAGVNLALIKRYFDSKEGLFKAALAGTPRFLGGEFPQDRAALAEALS
                     HQLSAGAWPEFGEHPVLLLLRVSGDERVDSLRRQALQDFSRRVLEASGAGRDDDERLLR
                     AELLVALGVGIAVVRSTVGLQPLGDATSDDLIGPLRDVVDSLLG"
     gene            complement(5027..6061)
                     /locus_tag="KLK06_RS21415"
                     /old_locus_tag="KLK06_21405"
     CDS             complement(5027..6061)
                     /NRPS_PKS="Domain: PKS_ER (15-219). E-value: 1.8e-11.
                     Score: 35.6. Matches aSDomain:
                     nrpspksdomains_KLK06_RS21415_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040: alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012335.5"
                     /locus_tag="KLK06_RS21415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21405"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_214637293.1"
                     /sec_met_domain="ADH_N (E-value: 3e-18, bitscore: 61.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 7e-16, bitscore:
                     53.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSVQTSTSGTVEVVDLERPVPGPNDVLLRVRACGICGTDTTFIH
                     MGGMPQGPEGRTRPVALGHEPTGEIVEVGSAVTGLTVGDRVVVNPQAAPSGIIGCGGAL
                     GGMRDYLIIEDAAVGKSVAVIPDSLPFDVAALNEPMAVARHCVNRSEARPEDKVVVFGA
                     GPIGLGAAIWLKLRGVRHVVVVDVIAERLKTALAVGADAVIDSSHQDVTARLLELHGEG
                     ANALGATRPDTDIYIDAAGAAAVINTATASAKWGAKLVMVAVQKKSAAIDLGAMLRSEM
                     TLIASQGYPTEIFEVTAEIAEHQERFARLISHRVPFAEAERAFQLALTPGAAEKVVVTF
                     DDHQ"
     aSDomain        complement(5405..6016)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KLK06_RS21415_PKS_ER.1"
                     /evalue="1.80E-11"
                     /label="KLK06_RS21415_PKS_ER.1"
                     /locus_tag="KLK06_RS21415"
                     /protein_end="219"
                     /protein_start="15"
                     /score="35.6"
                     /tool="antismash"
                     /translation="DLERPVPGPNDVLLRVRACGICGTDTTFIHMGGMPQGPEGRTRPV
                     ALGHEPTGEIVEVGSAVTGLTVGDRVVVNPQAAPSGIIGCGGALGGMRDYLIIEDAAVG
                     KSVAVIPDSLPFDVAALNEPMAVARHCVNRSEARPEDKVVVFGAGPIGLGAAIWLKLRG
                     VRHVVVVDVIAERLKTALAVGADAVIDSSHQDVTARLLELH"
     gene            complement(6094..7272)
                     /locus_tag="KLK06_RS21420"
                     /old_locus_tag="KLK06_21410"
     CDS             complement(6094..7272)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017570076.1"
                     /locus_tag="KLK06_RS21420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21410"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_214637294.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.3e-55, bitscore:
                     183.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIVVVGASAAGLAAAETLRREGFTGPLTLIGDEPHLPYDRPPL
                     SKQLLAARWEPDRLTLRSPEDLGALDLDLRLGVSATGLDRDARTVRLSDGGHVRYDGLI
                     VATGVRPRRLPGHGAHVLRTLDDALALRGRLGRGRRLVVVGAGFLGAEAAAVARGLGCE
                     VVLLEPAPVPLAHAVGAAVGRVLSRAHLEHGVDLRTGITVTEATGSGVRLAGGDLVEAD
                     EVLVAVGSVPNTEWLAGSGLTVDDGLVCDEYSAAAPDVYGAGDVARWHNPLFGVRMRIE
                     HRTNAAEQGMAAARNLLRPGARRAFAPVPYFWSDQYDMKIQAHGYLRGHDAIAVVEGDL
                     DERRFVAAYRTGDRLAGALSVGMPPKALRPWRQAIAAGAKWHEVVGETTLAA"
     gene            complement(7269..7466)
                     /locus_tag="KLK06_RS21425"
                     /old_locus_tag="KLK06_21415"
     CDS             complement(7269..7466)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0009055 - electron transfer activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615965.1"
                     /locus_tag="KLK06_RS21425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21415"
                     /product="ferredoxin"
                     /protein_id="WP_214637295.1"
                     /transl_table=11
                     /translation="MRVELDEPKCVASGQCVLAAPEVFDQRADDGVAILLDETPAAELH
                     DGVREAAAICPAAAIRLVAT"
     gene            complement(7498..8727)
                     /locus_tag="KLK06_RS21430"
                     /old_locus_tag="KLK06_21420"
     CDS             complement(7498..8727)
                     /EC_number="1.14.-.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016712 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, reduced flavin or flavoprotein as one
                     donor, and incorporation of one atom of oxygen [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012893499.1"
                     /locus_tag="KLK06_RS21430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21420"
                     /product="cytochrome P450"
                     /protein_id="WP_214637296.1"
                     /sec_met_domain="p450 (E-value: 2.7e-26, bitscore: 87.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDALTSTGGSVPGYPMTRDAGCPFHPPATVRRLTAEAPVSKVRI
                     WDGSLPWLITRHADQRTLLTDPRISIDENLPGFPHMTRGRAEVAKVTPPLITNTDAPEH
                     TRLRRMVNVPFTVKKVEALRPAIQQITDELIDAMLAGPKPADLVTALGLPVPTLVISEL
                     MGVPYEDNEFFHHNSSVALSHGSSARQAQEASTALVGYLDGLIERKMSAPADDMLSELA
                     ARIKAGEMTRAEAATMGVAVLIAGHETSASMIPLGTLALLRHPDQLAVLRDTDDPKVVA
                     AAVEELLRYLTIVHTGVRRIAREDIEIGGQVIRAGDGIIFDLSAANWDAEMFPEPERLD
                     LGRSARLHQAFGYGPHQCLGQSLARVELQVVYSTLYRRVPTLRLATSVDEIEFAFEGIA
                     YSLRSLPVTW"
     misc_feature    8828..8843
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            8940..9524
                     /locus_tag="KLK06_RS21435"
                     /old_locus_tag="KLK06_21425"
     CDS             8940..9524
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="KLK06_RS21435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21425"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_214637297.1"
                     /transl_table=11
                     /translation="MAVKAAQKASGEPHTRERLIDVAVRLFTQRSFAGTSLQMIADEMG
                     ITKAAVYHHFRTREELLTAVVEPVLRRLRAIIETAETKRTPHARAEHLLTGYVDLSVEH
                     RAVVAVFANDAGAIEMLRAQPETSDLINRQLNLLADVTPGPAGRVNAAMVMAGIAAAAG
                     PALVRLDDDTLRKHLTGAGRRTLGLRAPRRL"
     gene            complement(9807..9968)
                     /locus_tag="KLK06_RS21440"
                     /old_locus_tag="KLK06_21430"
     CDS             complement(9807..9968)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS21440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_21430"
                     /product="hypothetical protein"
                     /protein_id="WP_214637298.1"
                     /transl_table=11
                     /translation="MWQAVSPQVGPRTVWQAGQVSWVGQPWHVAQFVWQVSQVFSPQVW
                     QVFWSQLV"
     gene            10001..11344
                     /locus_tag="KLK06_RS21445"
                     /old_locus_tag="KLK06_21435"
     CDS             10001..11344
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="KLK06_RS21445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21435"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_214637299.1"
                     /sec_met_domain="LANC_like (E-value: 1.9e-56, bitscore:
                     186.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATTKSVWAAVLPSAMGARAVSVAQEVAGRMRDPRQVRVYAENA
                     SRQSDFAAYRRWRPSDVAQGDAGLALLFGYLDACLPGDGWDVCAHDCLSLAARDAQDMT
                     HVRPSLFGGIAGVAFAAHSLSRDGSRYRRLLGELDRWLAPQAAQRARWLEQAGAGVSVG
                     AFDVIAGLAGIGAYLLCRRQDAGAARALEAVLAGLVALCGDRGGLPNWHTPIGAMGADE
                     PMARQFPHGNLNCGLAHGIPGPLALMSLAMRAGITVPGQREAVQRVADWLVEHRADDEW
                     GANWPSAVALPSPDSPAAQPRPGRSAWCYGSPGVARALWLAGSALEAPQLCALAVEAMT
                     ATYRRPRNRRFIDSPTFCHGVAGLLQITSRFANDTGDPMFVQAAADLTEQILRLYQPDL
                     PLGFSDLEPGGNRVDQPGLLDGAPGVVLALFAAATDVPPAWDRLFLLS"
     gene            11341..14382
                     /locus_tag="KLK06_RS21450"
                     /old_locus_tag="KLK06_21440"
     CDS             11341..14382
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="KLK06_RS21450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21440"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_214637300.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.3e-169,
                     bitscore: 559.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.5e-10,
                     bitscore: 36.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.2e-49, bitscore:
                     162.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLYRPLDWFVVRTPLLPVEDYLALGEGPPECVRGTALPADARVR
                     RALLVGGGDLPRALARSFKDDRARRKSARKLRRYLTRMSTRPTPYGLFAGVGLGAWGER
                     TGLTLTADQPRIHTRPDMEWLLSMVTELERRAEVRTGLRWFANPAAFIRAGRVRLGERA
                     TAGDGATGAVSLRATAPVLRALEVAREPIPYHRLFDELTGGSAATADKVARLLDQLWAH
                     GVLLTDLRPPLTGGDPARQVARRLAELPATHTEAKSLDHLLEAMSRWDRLPPEAGADRF
                     ADLVEQAESVHPAAPGRARLQSDMALPLGGRTVHRRVAVEVARAAELMLRLSPMPRGSA
                     VLDSYRRAFEARYGPGTEVPLLELLDPEIGLGPPVHSYGSRTAATNRHQILLDLALEAI
                     RDGRRVVDLDEAALTALETWEPSPSAAPTSLDISVFVLAASPSAVDDGDFSLVIGPNQG
                     GGAAGRTLGRFAHLIGHDAVAALARAARAEAAARPGRLWAEVDYQPRRARSGNVTIRPL
                     VRDHAIVLDAVPAAPGRAVPVDELFVGVRDGRFVVRWPALDLDVMGCAGHMLNGRQAPA
                     VVRFLDEVACAGQPRLGGFGWGPAAQFPFLPRVRVGRVILTPATWRVPGMRPGSFAAWR
                     ERWRLPRYVYLAFGDNRLLLDLADPAQLDEVHHELDRLPRDGTLILQEALPGPEDAWLP
                     GADGHYISELLVPVVLDHEEPPPPSTVRRAAPVTRSVQATDRLRPPGSDWLYVKLYHAL
                     ESADELIAGRVREFGATVRADGLADDWFFLRYADPEPHLRLRLRGDPDALATVLTPLLF
                     RWATSLIDAGRCSRFCVDTYDREIERYGGPDGLAVAETLFAVDSRAVADLLDLAHRGPG
                     LDRTLTAARTVDDLLAAMGLDEAGRATWYRDRAPASPATGTEYRRRQAELRSVLGDPAW
                     LPAQPAGPELEQLLRDRAAGIRAVTRRLDDLDARGALWVPRKQLMSSFVHMHCNRLLPG
                     GPASEQRLLGLLSRTRESLRHAPL"
     aSDomain        11773..12036
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KLK06_RS21450_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.10E-11"
                     /identifier="RREFam001.1"
                     /label="KLK06_RS21450"
                     /locus_tag="KLK06_RS21450"
                     /protein_end="232"
                     /protein_start="144"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FANPAAFIRAGRVRLGERATAGDGATGAVSLRATAPVLRALEVAR
                     EPIPYHRLFDELTGGSAATADKVARLLDQLWAHGVLLTDLRPP"
     gene            complement(14385..15824)
                     /locus_tag="KLK06_RS21455"
                     /old_locus_tag="KLK06_21445"
     CDS             complement(14385..15824)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012895610.1"
                     /locus_tag="KLK06_RS21455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21445"
                     /product="MFS transporter"
                     /protein_id="WP_214637301.1"
                     /transl_table=11
                     /translation="MSDLDSGTITTKVPARLDRLPWSRWHWMIVIGLGTVWILDGLEVT
                     IVGNLSAQLAKPGSGIDITQAQVAGLAAALYVAGACTGALFFGWLTDRFGRKKLFLITL
                     VVYLVATLMTAFSFDAWWFFLFRFMTGFGIGGEYAAINSAIDELIPSAHRGRIDIIING
                     SYWLGAAGGALLTVPLLNDLPVNIGWRVAFGMGVVLGLAILLVRRHVPESPRWLFIHGR
                     GQEAENIVDDIERQIGGDLPEPARSMTIHQRKSIGFVRIAHTMVALYPKRTVLGLSLFI
                     GQAFLYNAITFGYAQILSTFFKIDTHTGYYFAVIAVGNFLGPLLLGPLFDTVGRVPMIS
                     ATYIGSGLLLLGTAWLFNQGVLTAVTLTACWSVVLFVASAGASSAYLTVSEIFPMETRA
                     MAIAFFFAIGTAAGGIAGPLVFSHLVETGAPGDTALAFSIGAIIMILGGLVELFLGVKA
                     ERKGLEEIAAPLTAAKVDKAA"
     gene            complement(15904..16314)
                     /locus_tag="KLK06_RS21460"
                     /old_locus_tag="KLK06_21450"
     CDS             complement(15904..16314)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017582378.1"
                     /locus_tag="KLK06_RS21460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21450"
                     /product="VOC family protein"
                     /protein_id="WP_214637302.1"
                     /transl_table=11
                     /translation="MDITIHWTFLPHDNPDASLAFYRDVLGFEVRADVRHDGRRWITVG
                     PADQPGTSIVLEPPATGLGITDDERRTIVEMMAKGTYARITLATADLDGTFARLQAGGA
                     DIVQDPTEQPYGVRDCAFRDPAGNLIRINELH"
     misc_feature    16339..16357
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.31"
                     /tool="antismash"
     gene            complement(16373..17056)
                     /locus_tag="KLK06_RS21465"
                     /old_locus_tag="KLK06_21455"
     CDS             complement(16373..17056)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013718.5"
                     /locus_tag="KLK06_RS21465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21455"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_214637303.1"
                     /transl_table=11
                     /translation="MTKAEHVKYYALTILVPMLLMAAVTFGVGKLILAWPTGEADVSRA
                     LAADRTPLWNTLTDYGTSLSDTPYIVALTVIVAIVFRLVYKRWRESIFLVAAVWSQSLI
                     FLATTTPVGRQRPPVQHIDPAPPTSSFPSGHVSAAVGFYCAVALVLTMHVRNRALQVVI
                     WVLGVAAPLIVGFSRLYRGMHFLTDVTWGLLLGVGCVVMAARAILYRRERQQRRRPLSE
                     LVRPA"
     misc_feature    complement(17012..17014)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(17043..17789)
                     /locus_tag="KLK06_RS21470"
                     /old_locus_tag="KLK06_21460"
     CDS             complement(17043..17789)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542046.1"
                     /locus_tag="KLK06_RS21470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21460"
                     /product="phosphatase PAP2 family protein"
                     /protein_id="WP_214637304.1"
                     /transl_table=11
                     /translation="MRRQWLKARVDRDRSLGLRLTVASLAVALIMIPFSLLLVVAKMPA
                     NGLDASVAEDLHEYALAHPAVTRVLIVWTDLFGPWPWRIAVIAYAGWLLYKGAPRLAIW
                     AVTTVTVGGLLGLALKIITARARPHLPDPVALAPGDSFPSGHAVNVTLGAGVIVLLILP
                     RLPRWGRRVAWAVAWFLVLSVGYTRIALGVHWVSDVVAGIVLGTAVVAATAAGFETWRR
                     EQGRRPASPLTEGVDPESVKVTHDQS"
     gene            17888..18775
                     /locus_tag="KLK06_RS21475"
                     /old_locus_tag="KLK06_21465"
     CDS             17888..18775
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020542045.1"
                     /locus_tag="KLK06_RS21475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21465"
                     /product="diacylglycerol kinase family protein"
                     /protein_id="WP_214637305.1"
                     /transl_table=11
                     /translation="MSPTVAVVAHRKKTLGAGLDRLRVLITEQDVGELLWYEVPKSKKA
                     RKKVREALKQGAELVFVWGGDGMVQRCADVMAGSGVPMAVLPAGTGNLFATNLGIPIDL
                     EEAVEIGFHGRREKLDLGLLNGEHFAVMAGAGFEAEMIADADGQAKKQLGKLSYVKAAV
                     RHVGGPLVPMKIKVDGTTWFEGDASCLLLGNVSMIAGGIEAFDDARPDDGWLEVGVSTA
                     KGPVQWARVIGRMATGRSDDSPFVRMTRARKVSARFATPLTYELDGGEREATTRLTAEA
                     VPGALTICLPADDR"
     gene            complement(18780..19988)
                     /locus_tag="KLK06_RS21480"
                     /old_locus_tag="KLK06_21470"
     CDS             complement(18780..19988)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009084092.1"
                     /locus_tag="KLK06_RS21480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21470"
                     /product="dipeptidase"
                     /protein_id="WP_214637306.1"
                     /transl_table=11
                     /translation="MEAPSVVASSSSSHRVTRLLREHPLIDGHNDLPWAARKLAGYDFD
                     RLDISGDTSDRTHTDLPRLAAGMVGGQFWSVFVPCRPAGDAVTATLEQIDCVLAMVRRY
                     PDRLALATTADEVERVFAGGRIASLMGAEGGHSIDCSLGALRMLYALGVRYMTLTHNDN
                     TPWADSATDEPVNHGLSAFGEEVVREMNRLGMLVDLSHVSADTMRDALRVTRAPVIFSH
                     SSARAVCSAPRNVPDDVLKTLAANGGVCMATFVPDFVSQDAREWRLAATDFARSAGVDT
                     HDYEAFHAFLNTWEKSHPRPAVTIDHVVAHLEHIRDVSGIDHLGIGGDYDGCDGLPRGL
                     EDVTGYPRLFAALADRGWSDADLAKVAGRNVLRVLRAAEATADDLRRREEPSTVRFTAA
                     ESG"
     gene            complement(20044..20835)
                     /locus_tag="KLK06_RS21485"
                     /old_locus_tag="KLK06_21475"
     CDS             complement(20044..20835)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020539761.1"
                     /locus_tag="KLK06_RS21485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21475"
                     /product="DUF1206 domain-containing protein"
                     /protein_id="WP_214637307.1"
                     /transl_table=11
                     /translation="MSEAEAVARRAADSPAMDKLARVGLVCRGVLYGLIGALAVQIAFG
                     DGGQQADKNGAISTVAALPFGAVILWVMVVGFAALALWQASEAIFGAHKLKDRIEPGSR
                     VVVYVLICAALLTMVLTGKTGSDDKRSQDLTGKLLELPAGQIIVGLIGLGILGLGIYWV
                     RYGIKKEFRKQLRPMPPRAGAVMNRLGLAGYLARGVIAGLAGVFVIQAAITFDPDKAGG
                     IDATLRAFADTPAGPWLLAVVALGLLLFALYCLGEARWRRT"
     misc_feature    complement(20626..20628)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20890..21783)
                     /locus_tag="KLK06_RS21490"
                     /old_locus_tag="KLK06_21480"
     CDS             complement(20890..21783)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS21490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_21480"
                     /product="DNA-3-methyladenine glycosylase"
                     /protein_id="WP_214637308.1"
                     /transl_table=11
                     /translation="MTTHGFTLTAEGPFDFGASLRFVEDWPATSALPSDGRALRFAYCA
                     ESDWRPIGVTVTAAPGGVAVATTRAAGPGIRGEVARILSLDVDGAGFTELGEADPVLGD
                     LQRLRPGLRPVCFWSTWEAACWAVIVQRSSMLIASRIKQRIAERYGAEVTVDGQVYAAF
                     PPPVTLLEAGGLGLPAQKEEWLRGLAGAALDGVLTAEHLRALGPEEALAELRALPGVGP
                     FSAGLILIRGAGAPDAFPGDEPRLFGILREAYGLPEDAPPAGYRKLAETWRPYRSWASF
                     LFRASTYGVMDDPVKV"
     gene            21878..22246
                     /locus_tag="KLK06_RS21495"
                     /old_locus_tag="KLK06_21485"
     CDS             21878..22246
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013742.5"
                     /locus_tag="KLK06_RS21495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21485"
                     /product="O-methyltransferase"
                     /protein_id="WP_214637309.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 9.9e-07,
                     bitscore: 23.5, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDATLRKIIAELNAAAAQHDAGQEDRLDRWRVLEPDAGEFLWFLA
                     QSAGARIIVEIGTSRGVSTLWLADAARAVGGHVLSLDTDAEAQAHARRRVACSWQTTPC
                     PTPRRSPRCTTFSSGSRA"
     misc_feature    21890..21892
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            22478..22732
                     /locus_tag="KLK06_RS21500"
                     /old_locus_tag="KLK06_21490"
     CDS             22478..22732
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025379.5"
                     /locus_tag="KLK06_RS21500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_21490"
                     /product="antitoxin"
                     /protein_id="WP_214637310.1"
                     /transl_table=11
                     /translation="MSRIAEWLKKAEDLARGHSKQADKVLDRAERFAKERTGHKYDQHI
                     EKGVDEVQRRYGGGDPQGRQSPSPQPPEPPPQQPGQRPD"
     gene            22775..22909
                     /locus_tag="KLK06_RS61535"
     CDS             22775..22909
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS61535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_284735064.1"
                     /transl_table=11
                     /translation="MVARDHLPAILTATERSALRCSYGRAEGVKLGAAILVVDQFLGG"
     misc_feature    23001..23016
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    23012..23027
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 19.52"
                     /tool="antismash"
     misc_feature    complement(23665..23680)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.38"
                     /tool="antismash"
ORIGIN
        1 cgcggcactg cgggcggccg ggctgccgct caagccgctg gaccggctgc tgccgtacag
       61 cgacgggatc accgtggagc ggccggatcc ggtgggggac taccgggtgc cggacggacg
      121 tcacctggcc ggcctcaccg gccgcctcgt cgagctgctc gccgaaccgg tacccacgac
      181 ctgcctgtcc atgtacctcg ttccgcacac cgcggtggtc atagacgcgg tcgcggcggc
      241 gcgcgcggcc gggttcgcgc ccgacgtgca caccgtggcg aaagcggtcg gctccgacgt
      301 gaccaacgtg atccggtcgt gcttgcggga aggccggttc ggcgcggcga ccgtgctgtt
      361 caccacgttc ctggccaacg acgaggtcgt cgcggtctcc gagtacaccc gagacgagat
      421 cgtcgcctcg gccgagcagg tggacgccta ctgcggcacc aggttcgccg aacaatgccg
      481 gcgccgagta accgtcagct acccgccgat cgactccgcc gccttcctcg accgggatcc
      541 ggcgcgagtg gacgccgcgc tcgcgcgacg cggtctggag cgtgacggct acgtcctgtt
      601 cctgtcccgg gtgacccggg ccaaggggat ccacgacctg ttgatcgcct tcgagcggat
      661 gcgctgccgg tcgcgcgtga aactggtcgt cgccggcacc gggcccgcgc tggaggaggt
      721 gcgggcgatg gccaaggagg acgaccgggt ggtcttcctc accgatgtcg acgaccacga
      781 gaagtcgctg ctcatgcgcg gctgcgcggc ctacgccctg cccaccaagc ccgagcccga
      841 cttcgtcgag acgttcggca tcgccctggc cgagaagatg ctggccggcg gtggaccgat
      901 catcaccacc gacacgggcg ggaccctgga ggcggtcggc gacaccgctg tcatcgtcga
      961 gcccggggac atcaccgctc tggccgaggc ggtggaccgg gtggtcctgg acatgtccgc
     1021 cgccgatcgg caggacctgg agcttcgcgc ccgcacccgc gcgatggcct tcgaccgggt
     1081 cgcggtcttc gacgggctgt tcccgggggc ggcgcccacc gcctaccgtc acaccgcctg
     1141 acgctagtcc aggtccaggt ccgagccgcc gaaccggtcc cgcaggaagc ggccctggtc
     1201 acgcagcgcc tgctcgtccc cgcggtgaat ggcgtcggcg accttgcgta gctgcgcgtc
     1261 gaggagggcg agctgggcca gcagctcctc gtgcgcgctc cgctcgcggt ccgcccgccg
     1321 cgttaccggc cgaggcgctg tatcgggacg ctggagggga aggcgaaggc gtagcggctc
     1381 agagaacggc ggccagagcc acgccggaga attcacccgc cgttcacgga gcgtgggcgt
     1441 cgatggagcc gctcggtcag gtgaccttgg aggcgggagc ggtgtaggtg ttgcacgccg
     1501 acggtgaggc cgcgtcgaag ccgcgtcgct gccagtagac gcggttcttc gccgttccga
     1561 accccttgta gcttccttcc accgcgtgcc ggctgatgaa gaactcggag ccgtgcgcgc
     1621 gggaatgccc cagcgaatcc cagacgctgc cgatgaacgc gcccgccaag cagatgctct
     1681 ggagcgagcc cttggtggtg agcgcgaggg ctttggcctt gggcagtttc ttgacggctc
     1741 gatattcctg gtcgacgatg ccgaccatgt tctgcgcgtg atagccgtag ccgatggaga
     1801 ggctttccag aattcccggg ctgtcgagct cgtcgcgcag gccgtagtcg gtgagcatca
     1861 ggtagatggt cttgttgggg atgcagtaga ggctgtagac gtcatccggg tggtagacgc
     1921 cgcaggcggt cttgatccga tcgccgtact tcacgacgac cttggccttc tggtaccgga
     1981 agccggcctt cgtcacctgc gtcgaccagg ccttttcctg gcatgcggta atggcttcca
     2041 cgtacaggcg gatcgcgtcg tgatcctggt tgacgtcagg ctcttcgcac gtctgggcag
     2101 ggagcttgcc tgtcttgtag agcgggttct tcgtgaaggg gtcgggggtg ggggccgcgt
     2161 gggccgtgcc ggtcagcgat aagaaggtga ccagggcggc ggcgagaatg cgcatgagag
     2221 tgcaccctag tggatcatgc agttacggtc atgccaccgg ataacgcttc ctgtcacgga
     2281 tattgacggg tatggcgaag gaagttacgt ttcgtcggca gatcgggggc cctagcgtca
     2341 caaaggagcc aacccatgat ccgaaaaacg ctgacgttct gcgcgatcgc cgcgttactc
     2401 atcggactcc ccaccgccgc ccgggcggcc gacgccaccc gtacaccagg gtcgcccacc
     2461 tacaccgtga ctctgaccag caacgcctcg ggcaccacgt ggaccggcca cgagagcgtc
     2521 agtttcacga acttatccgc ggaccccctc aacgaggtct acctgcgcct gtgggacaac
     2581 taccacggaa gctgcccgtc caccccgatc acggtcacga acgtcagcgg cggcacggcg
     2641 agcgcgctga gcgtcgcctg cacggcgctg aagatcacgc tcccggcgcc gctcgcccag
     2701 gggcagaacg gctcggtcgg cttcgacctg agcatcgtcg tacccagcgg cgccgaccgg
     2761 ttcggtcacg acggcgcgta caacttcatc ggcaacgccc tgcccgtgct ggccgtacga
     2821 gacggcgccg gctggcacct ggacccctac accaacaacg gcgagtcctt ctaccagctc
     2881 gccagcgact accgcgtcac cctggaccac cccagctcgc tgctcgtgcc cgcgaccggc
     2941 acctccgtgg acacgcccgg cagcgccggc cggacgatca cgaccgcgac cgccacgcac
     3001 gtccgtgagt tcgcctgggg ggccggcgcg ttcaccaaga ccaccggcac gaccagcacg
     3061 ggcgtcaccg tgaatgtcta ccgcgtcagc ggcatcagcg ccgccagcgc cgcctcgatg
     3121 atgacgaccg ccacgggctc gctggtcgcc cacgccggcc gcttcggcgc ctacccctat
     3181 ggcgaggtcg acatcgtcct ggacaacaac ttctggttcg gcggcatgga gtatccgggg
     3241 ttcgtactcg acctggtcag ctccaccgcg ctcgcccacg agctggccca ccagtggtgg
     3301 tacggcatcg tcggcgacga cgagtacaac accccgtggc tggacgagtc cttcgccgac
     3361 tacgccaccg acctgtaccg gggcatcacc ggcaccaact gctggaacag cgtcgtctgg
     3421 gcgtcatcgg ccgagaggat cagcaactcg atggcctact gggacgccca ctccagcagg
     3481 tacggcaccg tcgtctacac ctacggcaag tgcgccctgc acgacctgcg ccgcctgatc
     3541 ggcacgtcgg ccatgcagac gctcctgcac gactacgccg cctcccactg gtacggcatc
     3601 tccacggtgg ccgacttcaa ggccgccgcc caggccgcca cgacggtcga cctgtcgtcg
     3661 ttctggacca cgcaccgcat ctaacgcctt cgtcagcgcg tcgctgccca gccggccacg
     3721 gtggtgacat ccgcctggtg gggaaacacc ttctctgtca gtacgcgatg cacctccggg
     3781 tcggcgtcga ggcatccgtc ggccaggacg gtgaggccga agtccaggtc ggccgcttgg
     3841 cgcacggtgg acagcacgac gccgctcgtg gcgatgccgg tgaggacgag gtgatcgacg
     3901 tcgccggccc gcagcaccat gtcgaggtca ctgccggcga aggcgctgac gcgtcgcttg
     3961 gtgaccagga cgtcgccggg ttcgggtgcc acgtccggat ggatctggct ggcctggtcg
     4021 ccgccgacca gtggcgtggt gcccgcgagc cgaccgaaca tcttgttgcg gacgctgatc
     4081 tccgggtacc cgggacggaa cccgacgacc acatagatca ccggaacgcc gcccgcgcgg
     4141 gcggcgccga tcgcctcgcg tagacgcggc aggtaggcgg ggtcggggta acggtcgacg
     4201 acgacgcgtt ggacatccat gacgaggaga gcctgcttgg ccactgttgt ccttccatgc
     4261 cgcggaggca agtcatcagc tgattacttg gcagcgtagc caggtgccgg aaccatgtca
     4321 acgagtgatt acttggcgac gtcgcagagc tatgctgcgg tgacgtgtcg gaattgatga
     4381 cgttgcgaag gaggtcgccg gtggcgacga gaaagaccga cgggtctccg gacgacgccg
     4441 ccgccggaca gcccgccggg ggtcgccggc ggcgggacgc ggccgcgacc cgtgaggcgc
     4501 tcctccaggc cgcgcgcgac cggttcatgc gtctggggta cgaccgcacg acgctgcggg
     4561 acgtcgccgc ggacgcgggg gtcaacctcg ccctgatcaa gcggtacttc gactcgaagg
     4621 agggcctgtt caaggcggcg ctggccggta cgccccgatt cctggggggc gagttcccgc
     4681 aagaccgcgc cgccctcgcc gaggccctca gccaccagtt gtcggccggc gcctggccgg
     4741 agttcggtga gcacccggtg ctgctgttgc tgcgcgtctc cggcgacgag cgggtggaca
     4801 gcctgcgcag gcaggccctg caggacttca gccggcgagt gctcgaagcc tcgggcgcgg
     4861 gacgggacga cgacgaacgc ctgctgaggg cggaactcct ggtcgcgctg ggcgtcggca
     4921 tcgccgtcgt acgatccacc gtcggcctgc agcccttggg tgacgcgacc tccgacgatc
     4981 tgatcggccc gctccgcgat gtcgtcgaca gcctgctcgg ttagcactac tgatgatcgt
     5041 cgaaggtcac gaccaccttt tccgccgcgc ccggcgtcag ggcgagctgg aaggcccgct
     5101 cggcctcggc gaacggcacg cggtgactga tcagccgggc gaagcgctcc tggtgctcgg
     5161 cgatctccgc cgtgacctcg aagatctccg tggggtagcc ctgggacgcg atgagcgtca
     5221 tctcgctcct gagcatcgcg ccgaggtcga tggcggccga cttcttctgc acggcgacca
     5281 tgacgagctt cgcaccccac ttcgccgacg ccgtcgcggt gttgatgacg gcggcggcac
     5341 cggccgcgtc gatgtagatg tcggtgtccg ggcgggtcgc cccgagcgcg ttggcgcctt
     5401 cgccatggag ttccagcagg cgggccgtca catcctgatg agaggagtcg atgacggcgt
     5461 cggccccgac cgccagcgcg gtcttcaggc gttcggcgat gacgtcgacc acgaccacgt
     5521 gccggacacc gcggagtttc agccagatcg cggcgccgag cccgatcggc ccggctccga
     5581 acaccacgac cttgtcctcc ggccgggctt cggagcgatt gacacagtgc cgggcgaccg
     5641 ccatgggctc gttgagcgcg gcgacgtcga aggggaggga gtcggggatg accgccacgc
     5701 tcttgccgac ggccgcgtcc tcgatgatca ggtagtcccg catgccgccc agcgcaccgc
     5761 cgcagccgat gatgccggag ggcgcggcct gcgggttgac caccacgcga tcgccgaccg
     5821 tcaggccggt gaccgcggac ccgacctcga cgatctcgcc ggtgggctcg tgccccagcg
     5881 ccaccggcct cgtccgtcct tccgggccct ggggcatgcc tcccatgtgg atgaaggtcg
     5941 tgtcggtgcc gcagatgccg caggcacgta cccggagcag cacgtcattt ggtccgggaa
     6001 cggggcgttc gaggtccacg acctcgaccg tgcccgatgt gctggtctgt acagatctca
     6061 tggtggtgac tctcttcctg tgggcgggcg ggctcatgcc gccaacgtcg tttcgccgac
     6121 gacctcgtgc cacttggcgc cggccgcgat ggcctgccgc caggggcgaa gggctttggg
     6181 tggcatgcca accgaaagcg ctccggccag ccggtcgccg gtacggtagg cggccacgaa
     6241 ccggcgctcg tccagatccc cctccaccac cgcgatggcg tcgtggccgc gcaggtagcc
     6301 gtgggcctgg atcttcatgt cgtactgatc ggaccagaag tagggcactg gagcgaacgc
     6361 cctgcgcgcc ccagggcgca ggaggttgcg agcggcggcc atcccctgct cggcggcgtt
     6421 ggtgcggtgc tcgatgcgca tccgcacccc gaacagcggg ttgtgccagc gggcgacgtc
     6481 tccggcgccg tacacatccg gcgcggcggc actgtactcg tcgcacacca gaccgtcgtc
     6541 caccgtcagg ccgctgcccg ccagccactc ggtgttcggc accgagccga cggcgaccag
     6601 gacctcgtct gcctcgacca ggtcgccgcc cgcgaggcgc accccgctcc cggtcgcctc
     6661 ggtcacggtg atcccggtgc gcagatcgac gccgtgctca aggtgggccc gcgacagcac
     6721 ccgccccacc gccgcgccga ccgcgtgggc cagcggcacc ggcgcgggtt cgagcaggac
     6781 gacctcgcag ccgaggcccc gggccacggc cgcggcctcg gcgccgagga aaccggcgcc
     6841 gaccacgacc agccgccgcc cgcggcccag ccggccgcgc agcgccaagg cgtcgtccag
     6901 ggtgcgcagc acatgcgcgc cgtggccggg caggcgacgc ggacgcactc cggtggccac
     6961 gatcagcccg tcatagcgca cgtgcccgcc gtccgacagc cgcaccgtac gagcgtcacg
     7021 atcgagaccc gtcgcgctga cgcccaggcg aaggtcgaga tcaagggcgc ccaggtcctc
     7081 cggcgagcgc agggtcagcc ggtcgggctc ccaccgcgcg gccaggagtt gcttggacag
     7141 cggcggccgg tcgtacggaa ggtgtggttc gtcgccgatg agggtgagtg gccccgtgaa
     7201 gccctcccgg cgcagtgtct cggccgccgc gagtccggcg gccgaggcgc ctaccaccac
     7261 gatcctcttc atgtcgccac cagccggatg gccgccgctg ggcagatcgc cgcggcctcc
     7321 cgcactccgt cgtggagttc ggcggcgggc gtctcgtcca gcaggatcgc gacaccgtcg
     7381 tccgctcgct ggtcgaacac ctcgggagcg gccaggacgc actggcccga cgccacgcac
     7441 ttgggttcgt caagttctac acgcatggga cttcttcctt ctgttgctgg gagccggtca
     7501 ccaggtgacg ggcagggagc ggaggctgta ggcgattcct tcgaacgcga actcgatctc
     7561 gtcgaccgag gtggccaggc ggagtgtcgg aacgcggcgg tagagcgtgc tgtacacgac
     7621 ctggagctct acacgggcca gcgactggcc gaggcactgg tgggggccgt acccgaacgc
     7681 ctggtgcagc cgggcggacc ggcccagatc gagccgttcg ggctcgggga acatctcggc
     7741 gtcccagttc gcggcggaca ggtcgaagat gatcccgtcc ccggcgcgga tgacctgccc
     7801 accgatctcg atgtcctccc gggcgatccg gcggaccccg gtgtgcacga tcgtcaggta
     7861 gcgcaggagc tcctcgaccg cggcggcgac gaccttcgga tcatcggtgt cacgcagcac
     7921 cgcgagctga tcggggtgcc gcagcagggc gagcgtgccg agcgggatca tgctcgcgct
     7981 ggtctcgtgc ccggcgatca gcacggccac ccccatggtg gcggcctcgg cgcgggtcat
     8041 ctcgccggcc ttgatccggg cggccagctc cgacagcatg tcgtcggcgg gggcgctcat
     8101 cttccgctcg atcaggccat cgaggtatcc gaccagcgcg gtgctcgcct cctgcgcctg
     8161 ccgcgccgac gagccgtggc tcaacgcgac agagctgttg tggtggaaga actcgttgtc
     8221 ctcgtacggc acgcccatga gctcgctgat caccagcgtc ggcaccggta gacccagcgc
     8281 ggtgacgaga tcggccggct tcggcccggc cagcatggcg tcgatcagct cgtcggtgat
     8341 ctgctgaatg gcgggccgca gagcctcgac cttcttgacg gtgaacggga cgttgaccat
     8401 ccggcggagc cgggtgtgct cgggcgcgtc ggtgttggtg atcagtggcg gggtgacctt
     8461 cgcgacctct gcccggcccc gggtcatgtg gggaaacccg ggcaggttct cgtcgatgct
     8521 gatccgcgga tcggtgagca gtgtccgctg gtcagcgtgg cgggtgatga gccagggcag
     8581 gctgccgtcc cagatccgca ccttcgagac gggcgcttcg gcggtcagcc gccgtacggt
     8641 ggccggcggg tggaacgggc acccggcgtc ccgggtcatc ggatagccgg gaacggatcc
     8701 gccggtgctg gtcaatgcgt cggtcatggg tctccctcac ttcgatctcg ggccggaacg
     8761 gcaggtaacc gcctagccga tcggctagcc cattcctagc cgatcggcaa gcaaataagc
     8821 caggcattgt gaggtaagtc acttgccgat cggcaagttg gctgcttgcc gatcggcaag
     8881 ctacgatcga ggaattcggg aggtcgaacg cggcggggac gctgcggtga ggagcagccg
     8941 tggccgtcaa agccgcccag aaggcgtccg gtgagcccca tacgcgggag cggctcatcg
     9001 acgtcgcggt ccgcctgttc acccagcgca gcttcgcggg cacgtcgctc cagatgatcg
     9061 ccgacgagat ggggatcacc aaggcggccg tctaccacca cttccgcacc cgggaggagc
     9121 tgctcaccgc ggtggtggag ccggtgctgc gccggctgcg ggccatcatc gaaaccgccg
     9181 aaacgaaacg cactccccac gcgcgagcgg agcacctgct caccggatat gtcgacctgt
     9241 cggtggagca tcgagccgtg gtcgccgtct tcgccaacga cgccggcgcg atcgagatgc
     9301 tgcgcgccca gcccgagacc agcgacctga tcaaccgcca gctgaacctg ctcgccgacg
     9361 tcacccccgg cccggccggg cgcgtcaacg ccgccatggt gatggcgggc atcgccgccg
     9421 cggccggccc ggcactggtc cgcctcgatg acgacacgct gcgcaagcac ctcaccgggg
     9481 ccggccggcg caccctcgga ctccgcgctc cacgccgtct gtgagacggc ggtcttccgc
     9541 cctgctcacg gcaacggcgg cgcgggcgct cgttgccgat ttctggtcct gaccttgcca
     9601 ggccgtgaca ctatggagtc gcatcgtcac tgtgaggaag gtggtcaggt catgtgcccg
     9661 tcggatgatg acttcgatct ggacatccgg ctcggcaccc ccggggttcc cggtccgaac
     9721 gcgctggaca ccgacgtgac gagcacgtgc atcacgggct gccagacctg cgtcacctgc
     9781 aacacctgcc ccgcactgtg cacgcatcag accaattgcg accagaacac ctgccacacc
     9841 tgcggcgaga acacctgtga gacctgccac acgaactgcg ccacgtgcca tggttgcccg
     9901 acccaggaca cctgcccggc ctgccacacc gtgcgggggc cgacctgcgg agataccgcc
     9961 tgccacacct gcgacacctg catcgactgc ggatcgcgtc atgtctgcca cgactaagag
    10021 cgtctgggcc gcggtgttgc cgagcgcgat gggcgcgaga gccgtctccg tcgcgcaaga
    10081 ggtggcgggt cgcatgcgtg accctcggca agttcgggtc tacgcggaga acgcgagccg
    10141 acagagcgat ttcgccgctt accggcggtg gcgtccgtcc gatgtcgcgc agggagacgc
    10201 gggcctggcg ctgctgttcg gctacctgga cgcatgcctg ccgggcgacg gctgggacgt
    10261 gtgcgcgcac gactgcctga gcctggcggc gcgcgacgca caggacatga cgcatgtacg
    10321 gccgagcctt ttcggcggca tcgccggtgt cgcgttcgcc gcgcactcgc tgtcgcgtga
    10381 cggcagccgc taccgacgcc tgctcggaga gctcgaccga tggctggctc cgcaggcggc
    10441 ccagcgggct cgctggctgg agcaggccgg ggccggtgtt tcggtcgggg cgttcgacgt
    10501 gatcgcggga ctggccggga tcggcgccta tctactgtgc cgccggcagg acgcgggtgc
    10561 ggcgcgggcg ttggaggcgg tgctcgccgg gttggtggcg ttgtgcgggg accgtggagg
    10621 tctgcccaac tggcatacgc ccatcggtgc catgggcgcc gacgagccca tggcccgcca
    10681 gttcccgcac ggcaatctca actgtggcct ggcgcatggc atccctggtc cgctggccct
    10741 gatgtcgctg gcgatgcggg ccgggatcac cgttccaggg cagcgggaag cggttcagcg
    10801 ggtggctgac tggctggtcg agcaccgcgc ggacgatgag tggggcgcca actggccctc
    10861 cgccgtcgcc cttccctccc cggactcgcc cgcggcgcag ccgagacccg gccgcagtgc
    10921 ctggtgttac ggcagtccag gggtggcgcg ggcgttgtgg ctggccggtt cggcgctgga
    10981 ggcgccccag ttgtgcgcgc tggcggtcga ggcgatgacc gccacctacc gccgtccccg
    11041 caaccggcgg ttcatcgact cgccgacctt ctgccacggc gtcgccgggc tgctgcagat
    11101 cacctcgcgc ttcgccaacg acaccgggga cccgatgttc gtccaggccg ccgccgatct
    11161 caccgagcag attctccggc tctaccagcc ggatcttcca ctcggcttca gcgacctgga
    11221 gcccggcggc aaccgcgtgg accagccggg gctgctcgac ggcgctccgg gggtcgtgct
    11281 cgccctgttc gccgccgcca ccgacgtccc accggcgtgg gaccggctgt tcctgctgtc
    11341 atgagcctct accgtccgct ggactggttc gtggtacgca ccccgctgct gcctgtcgag
    11401 gattacctgg ccctgggcga agggccccct gagtgcgtcc gcgggaccgc gttgcccgcg
    11461 gacgcgcggg tccgccgtgc gctgctggtc ggcggcggtg acctcccgcg tgcccttgcc
    11521 cggtcgttca aggacgaccg ggcaaggcgt aaatcggccc gcaagctccg gcgatacctg
    11581 accaggatgt cgacccggcc gaccccgtac ggcctgttcg ccggggtcgg cctcggcgcc
    11641 tggggcgaac ggaccggtct caccctgacg gccgaccagc cccggattca cacccgtccg
    11701 gacatggaat ggctgctgtc catggtcacc gagctggaac gccgcgcgga ggtgcgtacg
    11761 gggctgcgct ggttcgccaa cccggcggcc ttcatccgag ccggccgcgt ccggctcggc
    11821 gagcgcgcga cggccggtga tggagctacc ggcgcggtct cgctgcgcgc caccgcgccg
    11881 gtcctgcgcg cgctggaggt cgcccgcgaa ccgattccct accaccggct gttcgacgag
    11941 ctcaccggcg gctcggcggc gaccgcggac aaggtcgccc ggctgcttga ccagttgtgg
    12001 gcgcacggtg tgctgctgac cgacctccgg ccgccgctga ccggcggcga cccggcccgg
    12061 caggtggccc ggcggctcgc ggagctcccc gcgacccaca cggaggccaa gtcgctcgac
    12121 cacttgctgg aggcgatgag caggtgggat cgactgcctc ccgaggcggg cgccgaccgc
    12181 ttcgccgacc tcgtcgaaca ggccgagtcc gtgcaccccg ccgcacccgg ccgggcccgg
    12241 ctgcagagcg acatggcgct cccgctgggc ggccggacgg ttcatcgaag ggtcgccgtc
    12301 gaggtggcca gggccgccga gctgatgctg cggttgtccc cgatgccgcg aggttcggcg
    12361 gtcctggact cctaccggcg cgcgttcgag gcgcgctacg gcccggggac cgaggttccc
    12421 cttctggaac tgctcgaccc cgagatcggt ctcggcccgc cagtgcactc ctacggctca
    12481 cgaacggccg ccacgaaccg gcaccagata ctgctggacc tggccctgga ggcgatcagg
    12541 gacggccggc gcgtcgtcga cctggacgag gcggccctca ccgccctgga gacctgggaa
    12601 ccgtcgccct cggccgcgcc gacttcgctc gacatttcgg tattcgtgct ggcggcctcc
    12661 ccgagcgccg tcgacgacgg tgacttctcg ctggtcatcg gccccaacca gggcggcggc
    12721 gccgccgggc gtaccttggg ccgcttcgcc cacctgatcg gccacgacgc cgtggccgcc
    12781 ctggcccgcg ccgcgcgggc cgaggccgcc gcccgccccg gccggctctg ggccgaggtc
    12841 gactaccagc cgcgcagggc gcgcagcggc aacgtcacga tccggccgct cgtccgcgac
    12901 cacgcgatcg tgctcgatgc cgttcccgcg gcgcccggcc gggccgtacc ggtggacgag
    12961 ctgttcgtcg gcgtccgcga cggccgcttc gtggtgcggt ggccggcgct cgatctggac
    13021 gtgatgggct gcgcgggaca catgctcaac ggccggcagg cgcccgcggt cgtccgcttc
    13081 ctcgacgagg tcgcctgcgc cggtcagccg cggctcggcg ggttcggctg gggcccggcg
    13141 gcacagttcc ccttcctgcc cagggtccgg gtggggaggg tgatattgac cccggcgacc
    13201 tggcgggtgc cgggcatgcg gccgggctcg ttcgccgcct ggcgggagcg gtggcggctg
    13261 ccgagatacg tctacctggc cttcggcgat aaccggctcc tgctcgacct cgccgatccc
    13321 gcgcagctcg acgaggtgca ccacgagctg gaccgcctgc ccagggacgg gacgctgatc
    13381 ctccaggagg cgctgcccgg gcccgaggac gcctggcttc ccggagccga cggccactac
    13441 atcagtgagc tactggtccc cgtggtgctc gaccatgagg aaccgccgcc gcccagcacc
    13501 gtacgccggg ccgcgccggt cacccggtcg gtccaggcca ccgatcgcct ccgtccgccc
    13561 ggcagtgact ggctctacgt caagctgtac cacgcgctgg aatcggcgga cgagctgatc
    13621 gccggccgcg tgcgggagtt cggcgccacc gtacgcgccg acggcctcgc cgacgactgg
    13681 ttcttcctgc gctacgccga tccggagccg cacctgcgcc tgcggttgcg cggcgatccc
    13741 gacgcgctgg ccaccgtcct gacgccgctg ctgttccgct gggcgacctc gctcatcgac
    13801 gccggacgct gcagccgctt ctgcgtcgac acctacgacc gggagatcga acggtacggc
    13861 gggccggacg ggctcgccgt ggccgaaacg ctgttcgcgg tggacagccg ggccgtggcg
    13921 gacctgctgg acctcgccca ccgcggtccc gggctcgacc gcacgctcac cgccgcccgt
    13981 acggtcgacg acctgctcgc cgccatgggc ctggacgagg ccgggcgcgc gacctggtac
    14041 cgcgaccgag cccccgccag tcccgccacc ggcacggaat accggagacg gcaggccgag
    14101 ctccgctcag tgctgggcga tcccgcctgg ttgcccgctc agcctgccgg accagagctc
    14161 gaacagcttc tccgcgaccg cgcggccggc atccgggcgg tcactcgtcg gctcgacgac
    14221 ctggacgcgc gcggtgcgct ctgggtgccc agaaagcagc tgatgtccag tttcgtgcac
    14281 atgcactgca accgcctgct ccccggaggc cccgcgagcg aacagcgcct actcggcctg
    14341 ctgtcccgca cccgcgagag cctccggcac gcgccgctgt agcgtcatgc cgccttgtcc
    14401 accttggccg ccgtcagcgg agcggcgatc tcctccaagc ccttgcgctc ggccttgacc
    14461 ccgaggaaga gctccaccag accccccaag atcatgatga tggcgccgat cgagaaggcc
    14521 agcgccgtgt caccaggggc accggtctcg accagatggg agaagacgag cgggcccgcg
    14581 atgccacccg ccgccgtgcc gatggcgaag aagaacgcga tggccatcgc cctggtctcc
    14641 atcgggaaga tctcgctgac cgtcagatag gccgaactgg cccccgccga ggccacgaac
    14701 agcaccaccg accagcaggc cgtcagtgtc accgccgtga gcactccctg gttgaacagc
    14761 caggccgtgc ccagcagcaa cagccccgac ccgatgtacg tggccgagat catcggcacc
    14821 cgcccgaccg tgtcgaagag cggcccgagc agcagcgggc ccaggaagtt gccgaccgcg
    14881 atgaccgcga agtagtagcc ggtatgcgtg tcgatcttga agaacgtgga caggatctgc
    14941 gcgtacccga aggtgatcgc gttgtacagg aacgcctggc cgatgaagag cgacaggccg
    15001 agcaccgtcc gcttgggata gagcgccacc atggtgtgcg cgatccggac gaatccaatc
    15061 gacttgcgct gatggatcgt catcgaccgc gccggctccg gcaggtcgcc gccgatctgg
    15121 cgctcgatgt cgtcgacgat gttctcggcc tcctggccac ggccgtggat gaacagccag
    15181 cgcgggctct cgggcacgtg tcgccgtacg agcaggatgg ccaggccgag caccacgccc
    15241 atcccgaagg cgacgcgcca gccgatgttg accggcaggt cgttcagcag cggcacggtc
    15301 agcagcgcgc cgcccgccgc cccgagccag tagctgccgt tgatgatgat gtcgatccgc
    15361 ccccggtggg cgctcgggat cagctcgtcg atggccgagt tgatcgccgc gtactccccg
    15421 ccgatgccga atcccgtcat gaacctgaac aggaagaacc accacgcgtc gaaggagaac
    15481 gcggtcatca gcgtcgccac caggtagacg accagcgtga tcaggaacag cttcttccgg
    15541 ccgaaccggt cggtcagcca gccgaagaac agtgcccccg tacaggcgcc cgcgacgtac
    15601 agcgcggcgg cgaggccggc gacctgcgcc tgcgtgatgt cgatgccact accgggtttg
    15661 gcgagctggg ccgagaggtt gcccacgatg gtcacttcga gcccgtccag gatccagacg
    15721 gtgccgagac cgatgacgat catccagtgc cagcgtgacc acggcagccg gtccagtctc
    15781 gcgggcacct tggtggtgat ggtgccgcta tccaggtcgc tcataaaatt cacccgatac
    15841 cctatgaccg gctgacaaac ctccggccgt caaggactca ggtcgcgacc gccgtacgac
    15901 ggatcagtgc agctcgttga tgcggatcag gttgcccgcg gggtcgcgga aggcgcagtc
    15961 gcgaacgccg tacggctgct cggtcgggtc ctggacgatg tcggcgccgc cggcctggag
    16021 gcgcgcgaag gtgccgtcga ggtcggcggt ggccagggtg atgcgggcgt aggtgccctt
    16081 ggccatcatc tcgacgatgg tgcggcgctc gtcatcggtg atgccgaggc cggtggccgg
    16141 cggctccagg acgatggacg tgccgggctg gtcggcgggg ccgaccgtga tccagcgccg
    16201 cccgtcgtgc cggacgtcag cgcggacctc gaagccgagg acgtcgcggt agaaggccag
    16261 agaagcgtcc ggattgtcgt gcgggaggaa ggtccagtga atggtgatgt ccatggcggt
    16321 caggctaggt gcggctcgaa ggcggacgct tctcgattcc tgatcggctt gttcacgcag
    16381 gtcggacgag ttcggagagc ggccgccgac gctgctgcct ctcgcgccgg tacaagatcg
    16441 cccgcgcggc catcacgacg cagccgacgc ccagcagcag gccccaggtg acgtcggtga
    16501 ggaagtgcat gcctcggtac aggcgggaga agccgacgat gagcggagcg gcgacgccga
    16561 gcacccagat caccacctgg agcgccctgt tgcggacgtg catggtcagg acgagcgcga
    16621 ccgcgcagta gaacccgaca gcggcgctga cgtgtcccga cgggaagctg gaggtgggcg
    16681 gggccgggtc gatgtgctgc acgggcggcc gctgccggcc gacaggcgtg gtggtggcca
    16741 ggaagatgag cgactggctc cagacggccg cgacaaggaa gatcgattcg cgccagcgct
    16801 tgtacacgag cctgaagacg atcgcgacga tcacggtgag cgccacgatg tagggggtgt
    16861 ccgacaggct ggtgccgtag tcggtgagtg tgttccacag tggggtgcga tcggcggcca
    16921 gggcccggct cacgtccgcc tcgccggtgg gccaggcgag gatcagcttg ccgacgccga
    16981 acgtcaccgc ggccatcagg agcatcggca ctaagatcgt cagcgcgtag tacttcacgt
    17041 gctcagcttt ggtcatgggt caccttcact gactcggggt ccactccttc ggtcagcggc
    17101 gaggcgggcc ttcggccctg ctcccgccgc cacgtctcga atcccgccgc ggtggcggcg
    17161 accacggccg tgcccaggac gatcccggcg accacgtcac tcacccagtg cacgccgagc
    17221 gcgatcctgg tgtagccgac cgacagcacc aggaaccagg ccacggccca cgccacccgc
    17281 cgcccccacc ggggcaacct gggcaggatg agaagaacga tcactccggc gccgagcgtc
    17341 acgttgaccg cgtggcccga cgggaaggag tcgcccggcg cgagcgcgac gggatcgggc
    17401 agatgcggcc tggcccgggc tgtgatgatc ttgagtgcga ggccgagcag cccgcccacc
    17461 gtcacggtgg tgaccgccca gatggccagc ctcggcgcgc ccttgtacag cagccagccg
    17521 gcgtacgcga tgaccgcgat acgccacggc cacggcccga acagatccgt ccatacgatg
    17581 agcactctgg tcacggcggg atgggcgagc gcgtactcgt gcagatcttc ggcgacgctc
    17641 gcgtccagcc cgttggcggg catcttggcc acgaccagca gcaggctgaa cgggatcatg
    17701 atgagcgcca ccgcgaggct cgcgaccgtc agccgcagtc ccagactgcg gtcacgatcg
    17761 acgcgtgcct tgagccattg acgcctcaca attccggtcc ttcctcgatg agcgttcgcg
    17821 ctcggctacc caggcagagg gaattgattc ctgcctgaaa gccggcggcg agggtagtcc
    17881 ggagggcatg tcccccaccg tggcggttgt cgcgcaccgt aagaagactc tcggcgcagg
    17941 cctggacagg ctgcgcgtgc tcatcaccga gcaggacgtc ggcgagctcc tctggtacga
    18001 ggtgcccaag agcaagaagg cgcgcaagaa ggtccgcgag gcgctcaaac agggtgccga
    18061 gctggtgttc gtctggggcg gcgacggcat ggtgcaacgg tgcgccgacg tgatggccgg
    18121 ctccggcgtg ccgatggccg tcctgccggc cgggaccggg aacctgttcg ccaccaacct
    18181 cggcatcccc atcgacctgg aagaggcggt ggagatcggc ttccacggac gacgggagaa
    18241 gctggacctg ggcctgctga acggcgagca tttcgcggtg atggccggcg ccgggttcga
    18301 ggccgagatg atcgccgacg ccgacgggca ggccaagaag cagctcggca agctgagcta
    18361 cgtcaaggcg gccgtccggc acgtaggcgg gccgctggtg ccgatgaaga tcaaggtcga
    18421 tgggacgacc tggttcgaag gcgacgcgag ctgtctgctg ctgggcaacg tgagcatgat
    18481 cgccggcggc atcgaggcgt tcgacgacgc ccggccggac gacggctggc tggaggtcgg
    18541 ggtctccacc gccaaggggc cggtccagtg ggcccgggtg atcggccgga tggccacggg
    18601 gcgctccgac gactccccgt tcgtccggat gacccgcgcc aggaaggtgt ccgcccggtt
    18661 cgccacgccg ctgacgtacg agctcgacgg cggagaacgc gaggccacca cccggctcac
    18721 ggccgaggcc gtcccgggcg ccctcacgat ctgcctgccg gcggacgacc ggtaaccggt
    18781 cagccgcttt cggccgcggt gaaccgtacc gtgctcggct cctcgcgacg ccgcaggtca
    18841 tcggcggtgg cctcggccgc gcgcagcacc cgcagcacgt tgcggccggc caccttcgcc
    18901 aggtcggcgt cggaccagcc ccggtcggcc agggccgcga acagccgggg atagccggtc
    18961 acgtcctcca gcccacgggg cagcccgtcg cacccgtcgt agtcgccgcc gataccgagg
    19021 tggtcgatgc ctgacacgtc gcgtatgtgc tccaggtgcg ccaccacgtg gtcgatcgtg
    19081 acggcgggcc tcgggtgcga cttctcccag gtgttcagga acgcgtggaa cgcctcgtag
    19141 tcatgggtgt cgacaccggc cgagcgggcg aagtcggtcg cggccagccg ccattcccgg
    19201 gcgtcctgcg acacgaagtc gggcacgaac gtggccatgc agaccccgcc gttggccgcc
    19261 agcgtcttca gcacgtcatc gggtacgttg cgcggcgcgg aacagaccgc ccgcgccgac
    19321 gaatgcgaga agatcaccgg cgcccgcgtc acccggaggg cgtcgcgcat cgtgtcggcc
    19381 gacacgtggg acaggtcgac cagcatgccc agcctgttca tctcgcgcac gacctcctcc
    19441 ccgaacgcgg acagcccgtg gttcaccggc tcgtcggtcg cggagtcggc ccagggggtg
    19501 ttgtcgttgt gggtgagcgt catgtagcga accccgaggg cgtacagcat ccgcagcgcc
    19561 cccagggagc agtcgatcga atgcccgccc tcggccccca tcaacgaggc gatccggccc
    19621 ccggcgaaga cgcgctccac ctcgtcggcc gtggtcgcca gggccagccg gtcggggtag
    19681 cgccggacca tggccagcac gcagtcgatc tgctccaggg tcgcggtgac cgcgtcccca
    19741 gcgggccggc aaggcacgaa gaccgaccag aactgcccgc cgaccatccc ggccgccagc
    19801 cggggcagat cggtatgggt gcgatcggac gtgtcgccac tgatgtcgag ccggtcgaag
    19861 tcgtatccgg cgagcttgcg tgccgcccag ggcaggtcat tgtgcccgtc gatcagcggg
    19921 tgctcgcgca gcagccgagt gacgcgatgc gacgaactgg acgacgcgac taccgaaggt
    19981 gcttccatgc cgatcagcca atcacaggat cggctcgcgc tcagcgcgcc acccggccga
    20041 gcctcaggtc cgccgccagc gagcctcccc caggcagtac agggcgaaca gcagcagccc
    20101 gagcgccacc accgccagca gccacggccc cgccggggtg tcggcgaacg ccctgagggt
    20161 cgcgtcgatg cccccggcct tgtcggggtc gaaggtgatg gccgcctgga tcacgaagac
    20221 cccggccaga ccggcgatca ctccgcgcgc gaggtagccg gcgagcccga gccggttcat
    20281 caccgcgccg gcccgcggcg gcatcggcct gagctgtttg cggaactcct tcttgatccc
    20341 gtaccgcacc cagtagatgc cgagcccgag gatgccgagc ccgatcagcc ccacgatgat
    20401 ctgtccggcg ggcagctcga gcagcttgcc cgtcaggtcc tgggacctct tgtcatcgga
    20461 tccggtcttg ccggtcagca ccatggtcag cagcgcggcg cagatcagca cgtagaccac
    20521 gacccggctg cccggctcga tccggtcctt gagcttgtgc gccccgaaga tcgcttcgga
    20581 cgcctgccac agcgccagcg cggcgaaccc cacgaccatg acccataaga tcacggcacc
    20641 gaacggcagc gccgcgaccg tactgatggc cccgttcttg tcggcctgct gcccgccgtc
    20701 gccgaacgcg atctggacgg ccagcgctcc gatcagccca taaagcacac cgcgacaaac
    20761 aagcccaacc cgcgcaagct tgtccatggc cgggctatct gccgcccggc gtgctacggc
    20821 ctcagcttcg ctcatgcgat tctcccgagt gtccgtcaaa gaccctcgaa ctgccccgga
    20881 tttcgcgctc tagaccttca ccggatcgtc catgacgcca taggtggacg cccggaacaa
    20941 gaaagaggcc caggagcggt agggccgcca cgtctcggcc agcttccggt acccggcggg
    21001 cggcgcgtcc tccggcaggc cgtacgcctc acgcaggatc ccgaacagtc gcggctcgtc
    21061 acccgggaac gcgtccggcg cgcccgcgcc gcggatcagg atcagcccgg cggagaacgg
    21121 ccccacgccg ggcagcgcgc gcagctcggc cagggcctcc tccgggccga gcgcgcgcag
    21181 gtgctcggcg gtgagaacgc cgtccagcgc cgcaccggcc agtccgcgca gccactcctc
    21241 cttctgcgcg ggcagcccga ggccgccggc ctccagcagc gtcacgggcg gcgggaaggc
    21301 cgcgtacacc tgcccgtcca cggtgacctc ggcgccgtac cgctccgcga tgcgctgctt
    21361 gatacgcgag gcgatgagca tcgacgaacg ctgtacgatc accgcccagc acgccgcctc
    21421 ccacgtactc cagaagcaca ccggccgcag gccgggacgg agccgctgca ggtcgccgag
    21481 caccgggtcg gcctcgccga gctcggtgaa accggcgccg tccacgtcga gggagaggat
    21541 gcgcgccacc tcgcctcgga tccccggccc cgcggcccgc gtcgtggcga cggcgacccc
    21601 gcccggcgcg gccgtcacgg tcacgccgat cggccgccag tcggactcgg cgcagtaggc
    21661 gaagcgcagc gcccgcccgt cggagggcag cgcgctggtg gccggccagt cctcgacgaa
    21721 gcgcagcgag gcgccgaagt cgaacgggcc ctcggcggtg agcgtgaatc cgtgcgtggt
    21781 catgggccgt atggtaaagg ccctccacct tggcaccaga cgcgaagccg actactaccg
    21841 gccggtgacc acgttacggg cagggcagaa tccggctatg gatgccacgt tacggaagat
    21901 catcgcggag ctgaacgcgg ccgccgccca gcacgacgcc ggccaggagg accggctgga
    21961 ccggtggcgg gtgctggagc ccgatgccgg ggagttcctg tggttcctgg cccagagcgc
    22021 cggagcccgg atcatcgtgg agatcggcac ctcgcggggc gtgtccacgt tgtggctggc
    22081 cgacgccgcg cgggcggtcg gcgggcacgt cctcagcctc gacaccgacg ccgaggccca
    22141 ggcgcacgcc cgccgcaggg tggcgtgctc gtggcagaca acgccctgtc ccaccccgag
    22201 gagatcgccc cgctgcacga ccttctccag cgggagccgc gcctgaccgt caccacgatc
    22261 aacgtgggca agggcgaact ggtcgcactg cggcgctgag agccaggtgg ttgaggcgct
    22321 ccctgatgcg gttccgttcg ccgggagtcg aacacgctcg tcgcggacgg ttgcgcggca
    22381 gtggcggtcg cggtcgtgcc ggcgatcgcc gcgaggtgtg acctcgcgcc gactccgggt
    22441 agggggcaac tgtaaggcac gagaaggggg cacgctcatg agccgcatcg ctgaatggtt
    22501 gaagaaggcc gaggacctgg cgagagggca ctccaagcag gctgacaagg tgctggatcg
    22561 cgccgagcgg ttcgccaagg agcggaccgg ccacaagtac gaccagcaca tcgagaaggg
    22621 cgtggacgag gtgcagcgcc gctacggcgg aggcgacccg cagggccggc agtcgccaag
    22681 cccgcagccc ccggagccac cgccgcagca gcccggtcag cgcccggact aacgacgtgc
    22741 cggtgccgcg cgcagcggcg tcggcgtccc cggcatggtt gcccgcgacc acctgccggc
    22801 gatcttgacg gccacggagc gctccgcgct gcgctgttcc tacggccgcg cggagggcgt
    22861 caagctcggc gccgccatcc tggtggtgga tcagttcctg ggcggctgag ggcccgcgtc
    22921 gtggcttatt ttcctatctg atttaaggat cgtacgaagg tgccgtcaac acttaattca
    22981 agtattgacg ctcttgtaag gtcaccgtaa ggtcaccata aggtcacgac cgtggatttc
    23041 tcttagccat ggcgctcacc cacgccggcg gctagccact ggcgtacacc ccccacagaa
    23101 ggtgacaccc cccatgaaaa gacgaggaat catccttgcc tccgtgacgg cgttagccgt
    23161 ggcgggcctc gctttcccgg cctgggccgc caccggccag atcaccggct acggcggcaa
    23221 gtgcgtcgac gtcgccggcg ccagcagcgc caacggcacc caggtccagc tctggacctg
    23281 caacagcacc actgcccagt cgtggaccac gcagtccgac ggcacgatcc gcgcactcgg
    23341 caagtgcctg gacgtggcgg gcgcgagcag cgccgacggc gccaaggtgc agatctacga
    23401 ctgcaacggc accgccgcgc agcagtggac ggccgcctcc gacggcaccc tgcgggcgct
    23461 cggcaagtgc ctggacgcca ccaacgtcag ctcggccgac ggcacgcccc tgcagatctg
    23521 gagctgcggc accggcgcca accagaagtg gacgctgccc tccggcggcg gcactcccag
    23581 tcccggcaag ctgcccggcg ctccctacct ctacatgggg tgggggagcc cgcccaaccc
    23641 gggcacggtc atggacgcga ccggcgtgaa gtccttcacg atggccttca tcctgtccgg
    23701 cggcggctgc gtgccacgct gggacggctc gcgtgcgctg acgggcggcg ccgaccagca
    23761 ggcgatcaac acgatcaagt ccaagggcgg cagcgtccag atctccttcg gcggctggtc
    23821 gggcaacaag ctcggcccca actgcggtac gcctgaggcg tacgcgggcg ccgtgcagca
    23881 ggtcatcaac gccctgggac ccgcggccgt cgacttcgac atcgagaaca ccgacgagta
    23941 cgagaactac accgtccagg accgcatact caacggactc aagatcgtca aggcgaacaa
    24001 cccgaacgtc aaggtggtcg tcaccttcgg cacctccacc agcggcccgg ccggcgcggg
    24061 cacccggctg atcaaccggt cgagggagct cggcgtcccg atcgacaact acacgatcat
    24121 gccgttcgac ttcggcggcg gctccaacat gtaccagagc acggtcaacg cggccgaagg
    24181 gctgaagaac gcgctgaagt cggcgttcgg ctggtcggac gccacggcgt acgcgcacat
    24241 gggcatctcc ggcatgaacg gcctgtccga ccagtcggag gtcacctcgg tcgccacctg
    24301 gacccagatt cgcgactacg ccaactccca tggcctgacc aggctcgcct tctggtcggt
    24361 caaccgcgac cgcccctgct cc
//
