LOCUS       NZ_JAHFZZ010000003     23285 bp    DNA     linear   CON 13-SEP-2024
DEFINITION  Nonomuraea sp. NEAU-A123 Scaffold3, whole genome shotgun sequence.
ACCESSION   NZ_JAHFZZ010000003
VERSION     NZ_JAHFZZ010000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Nonomuraea sp. NEAU-A123
  ORGANISM  Nonomuraea sp. NEAU-A123
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
REFERENCE   1  (bases 1 to 828258)
  AUTHORS   Zhang,L. and Zhao,J.
  TITLE     Nonomuraea triticisoli sp. nov., a novel actinobacterium isolated
            from rhizospheric soil of wheat in Langfang, Hebei Province, China
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 828258)
  AUTHORS   Zhang,L. and Zhao,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2021) College of Life Sciences, Northeast
            Agricultural University, Changjiang Road No. 600, Xiangfang
            District, Harbin, Heilongjiang Province 150036, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018603905.1-RS_2024_09_13
            Annotation Date                   :: 09/13/2024 04:26:49
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 11,983
            CDSs (total)                      :: 11,901
            Genes (coding)                    :: 11,761
            CDSs (with protein)               :: 11,761
            Genes (RNA)                       :: 82
            rRNAs                             :: 5, 3, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2, 2, 3 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 140
            CDSs (without protein)            :: 140
            Pseudo Genes (ambiguous residues) :: 0 of 140
            Pseudo Genes (frameshifted)       :: 28 of 140
            Pseudo Genes (incomplete)         :: 121 of 140
            Pseudo Genes (internal stop)      :: 3 of 140
            Pseudo Genes (multiple problems)  :: 12 of 140
            CRISPR Arrays                     :: 6
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 12:52:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 782703
            Orig. end                         :: 805988
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHFZZ010000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..23285
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23285
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="RRE-containing"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    1..23285
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13285](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13285
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    809..823
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.37"
                     /tool="antismash"
     gene            complement(1184..2665)
                     /locus_tag="KLK06_RS12090"
                     /old_locus_tag="KLK06_12075"
     CDS             complement(1184..2665)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF013646.5"
                     /locus_tag="KLK06_RS12090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12075"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_214635438.1"
                     /transl_table=11
                     /translation="MKSPVRIAIVGAGPGGLMCARVLQGHGIDVTVYDADASVEARDAG
                     GTLDLHADTGQIAMEDAGLFEEFMKLARLEGQAKSRLDQHGTVLDAFVPDQDDTAAPEI
                     DRGQLRAMLAEHVRPGTVHWGHKLVTATPLGDGGHRLEFGNGVTAEVGLVIGADGAWSR
                     VRPLLSDATPDYTGVSFLDVRFEDVETRHPQIAKLVGNGHLFANDGDGRAIIGQRNSNG
                     HIRAYLALRTDLDWHGKAGVDLGDAGAVRRFLLKEFSGWAEEMLPFLTDVDGGYLNRPI
                     YALPAPLTWAHTPGATLLGDAAHLMAPFGGYGVNLAMLDGAELAHAIAEEATLDEAITR
                     YEAVMLPRSGQHAVAANGGLDSFFASGDFGSADFPDHEAEHQRYREAAAAYRRGQSRAT
                     AVDGTWTVSFRTPRGRQQAELRLAATAGSLTGAFDGTPIQDGQVDGTEIGFVATLTSPF
                     KMKVTFTVSVEGDTMTGTAKAPMMTIPITGTRQTA"
     gene            2766..3368
                     /locus_tag="KLK06_RS12095"
                     /old_locus_tag="KLK06_12080"
     CDS             2766..3368
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012655.5"
                     /locus_tag="KLK06_RS12095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12080"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_214635439.1"
                     /transl_table=11
                     /translation="MSTNTGSDRRTGPETRAEILRVALRLFTEKGYEGTSTRDISSALG
                     MTKSSLYYHFQNKEEIVASLVEGRRHELDDFIEWLAAQPPTPDRLEKAALRWLQGTTPE
                     HLQAMLFAQANQPVMRRLAEGGRDIRSNFDRVIDLLVDEGASMEDRLLTRMVFDTAGAA
                     LLSARGTEADPDDVIAAARRATTALARATTEATKEAL"
     gene            complement(3470..4444)
                     /locus_tag="KLK06_RS12100"
                     /old_locus_tag="KLK06_12085"
     CDS             complement(3470..4444)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853838.1"
                     /locus_tag="KLK06_RS12100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12085"
                     /product="aldo/keto reductase"
                     /protein_id="WP_214635440.1"
                     /transl_table=11
                     /translation="MQQRNLGQQGLTASALGYGAMGISLAYGPSDKQEGAATVRRAHEL
                     GVTFFDTAELYGQGENERIVGAALAPVRDEVVIATKFGFDFTGTRQGGVDSRPEHIREV
                     VDNSLRYLGVDVIDVLYQHRVDPDVPIEDVAGTVKEFIEAGKVRYFGLSEAGENTIRRA
                     HAVQPVSVLQTEFSLFEREVEILFPVLRELGIGFVPYSPLGRGFLTGQAKPGAEYDSSD
                     MRTWDARFQPGNYEKNVAATRRLADLAATKDATVAQLALAWLLAQGDDIVPIPGTRDPK
                     RLEENVGAADLTLDDADLKRIADILPAGGFGARYPAEYLPTWD"
     misc_feature    4470..4487
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.15"
                     /tool="antismash"
     misc_feature    complement(4493..4510)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            4536..5171
                     /locus_tag="KLK06_RS12105"
                     /old_locus_tag="KLK06_12090"
     CDS             4536..5171
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024701.5"
                     /locus_tag="KLK06_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12090"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_214635441.1"
                     /transl_table=11
                     /translation="MSSPTTPRRGYHHGDLRAGLIREGIALLAETGVAGFSVAKVAVRA
                     GVSSAAPYRHFPDREALLAACAAAILADITDLLAAAAEQAGPDPLDRLAATAGAYTRYV
                     LEHRAGIDLIYSYEFSGPHHPTVQEQSRRLTGALMDLGSAVLPADVSWADTADFVYVHL
                     STTHGYATLLVKGTRPPQDIDSHAARAVTAARDHITGYLQRLNNRETA"
     gene            complement(5247..5600)
                     /locus_tag="KLK06_RS12110"
                     /old_locus_tag="KLK06_12095"
     CDS             complement(5247..5600)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888805.1"
                     /locus_tag="KLK06_RS12110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12095"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_214635442.1"
                     /transl_table=11
                     /translation="MDQSHPEGNDATLAQSKAEDRFGDEDYPAYSMGAAAEMLGVTPAF
                     LRALGVAKLIEPRRSGGGHRRYSRYQLRLAARARELVDQGTALDAACRIVILEDQLAEA
                     LRINSSRERPAEG"
     misc_feature    complement(5591..5604)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.06"
                     /tool="antismash"
     gene            complement(6130..6888)
                     /locus_tag="KLK06_RS12115"
                     /old_locus_tag="KLK06_12100"
     CDS             complement(6130..6888)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017543226.1"
                     /locus_tag="KLK06_RS12115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12100"
                     /product="TioE family transcriptional regulator"
                     /protein_id="WP_214635443.1"
                     /transl_table=11
                     /translation="MRLRPIDLAREHGLSTQAVRNYEEAGILPPAERSPHGYRAYAPRH
                     AAALRTFLALIPAHGHATAGAIMRAVNGGAVEEALRLIDESHAQLAGDRHTLEAVERAL
                     RDLASPRDRESPRELKPPRDQESLRGLASAREPASGVTFIGPLARRLGIRPATLRKWER
                     AGLIVPRRDPRTGYRVYTSADERDVLLAHQLRRGGHGLEQIARVLERVRAAGGPEPLQA
                     TMREWRDRLTTRGLAMLTGAGALDTYLGTP"
     gene            6966..8171
                     /locus_tag="KLK06_RS12120"
                     /old_locus_tag="KLK06_12105"
     CDS             6966..8171
                     /EC_number="3.1.1.-"
                     /GO_function="GO:0052689 - carboxylic ester hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017567423.1"
                     /locus_tag="KLK06_RS12120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12105"
                     /product="erythromycin esterase family protein"
                     /protein_id="WP_214635444.1"
                     /transl_table=11
                     /translation="MTTSIQDAAHPFTSGALTALLPPATRLLGLGEPTHGVEAFLDLRN
                     ELFRHLVEHEGYRSITMESDCLAALAADAYVTDGIGTLDNAMSQGFSHGSGASSANREL
                     LRWMRAYNEQRPPYERLHFYGFDGPLEISGPAGPRPALTALHDYLAAHLDLPWSRETLD
                     ELLGPDQRWTNPAATTDPTQSVGRTPEAKELRLITDDLRTLLTAHAPHLTATTSPDDLW
                     RADLHARTAAGLLRYHAGIADTAPTRVGTLMRLRDAMMADNLDAIIDREARRGPTLAFA
                     HNRHLQKDKSRWLLPEGWGPLGGRTLEWWSAGAIVGTRLGDQYAFAATTFGTRGSDVPH
                     PDTLEGLLSTLPDARAVIDPGGLAAALDRKPTPRVPADHTYFALDPATIDQSDAIVFVK
                     EI"
     gene            complement(8379..9041)
                     /locus_tag="KLK06_RS12125"
                     /old_locus_tag="KLK06_12110"
     CDS             complement(8379..9041)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF037183.5"
                     /locus_tag="KLK06_RS12125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12110"
                     /product="permease-like cell division protein FtsX"
                     /protein_id="WP_214635445.1"
                     /transl_table=11
                     /translation="MNSIEERLRDAMAARAEIVGDDDRPLPAPRPRRSSGGGLVRVAAA
                     TLTVAVTALAVAGLATSFLEPQENIVAMSLSGAVSAEGPEVAVFLCKAGDSFASCAGGE
                     ITTTERKNLQQALEAWPEVESVRFEGRQQAWENFRRQYEDNPELLKATTPTDMPESFRA
                     RIRAGADSSAVAQAASELPGVAMSVDQACLIDNGPPWGFVKRLLGTGEQCSFTGKGR"
     gene            complement(9038..9565)
                     /locus_tag="KLK06_RS12130"
                     /old_locus_tag="KLK06_12115"
     CDS             complement(9038..9565)
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="KLK06_RS12130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12115"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_214635446.1"
                     /transl_table=11
                     /translation="MDSEILRLAKSAPPVASPDAELVAFYRQHRLSLVRFAVLLVGDQE
                     TAEDVVQDVFARLHSMWRPGVTTIAYVRTCVLNGSRSVLRRRAVALRRVEPVAGLADSA
                     ETAALIGESRREVLRALARLPRRQREALVMRHYLDLSDAEIAEAMRVRQSTVRSMTARA
                     LARLLRELEDNA"
     gene            <9702..9896
                     /locus_tag="KLK06_RS63030"
                     /old_locus_tag="KLK06_12120"
                     /pseudo=""
     CDS             <9702..9896
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023903.5"
                     /locus_tag="KLK06_RS63030"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12120"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="EAFGQVIRIIVAAPVRRGAATARATPAAPRRHPAHARPRRPVRRA
                     SAEHDEDDLAALSDSPCVW"
     cand_cluster    9744..21678
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    9744..21678
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[14743:16678](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(14744..16678)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="2"
     gene            10001..13285
                     /locus_tag="KLK06_RS12140"
                     /old_locus_tag="KLK06_12125"
     CDS             10001..13285
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="KLK06_RS12140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12125"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_214635447.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.5e-189,
                     bitscore: 626.1, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-17,
                     bitscore: 59.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 7.4e-29, bitscore:
                     96.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAQRSQPYRHLDAALIRATAHPGEPDLPPWPEQDGEAGAERWRE
                     WLAQVWARDSVAAAVSMASPALASQIEAVCTGRRPRAGRLRRMALSLARYLVRMRARAT
                     PFGTFAGVTPLRFNTTQTGRTAVPHPGATLASDVPHTGAALMGWTGVPRTRTTADGVWL
                     AAVIARLESGPELRRRLPVVVNDLAFVRGERLVVPWQPHAGDPARSELSEVSVRHGPAV
                     RTVMDLAQGPIQIGELIDGLAAAFPGARVPAIEVMVAELVTCGALITSLRPPSTSPDGL
                     AYVLDRLGDVAADAFGEVTPLVRELRAIHEGLRAADHATGEAAVRARRAVADRMRAALP
                     VEVVQPLKVDLRLDGTVVLPPEVAAEAESAAGALLRLTPHPAGHPAWREYHVRFLDRYG
                     AGAVVPVEQLVDDTAGLGFPAHYGEPRQPAEPLSRRDQRLLALAQQAALDGAREIVLDD
                     ATIESLAADGMDDAAIENRARPLPYMELVAEVCASTAGALATGAFSMTVLAVDGTAACL
                     SGRFVDMLPDGDRRRMAGLYDRLPVSVDGAVPVQLSFPARNARTQEVARTPLLLPELIT
                     LAEHRADSPGRIPWRDLAVTADNDRMYLLSRSRRQVVEPVLTSAVARRAMPPIARLLFE
                     IPRARGAVVSPFSWGAAACLPFLPRVRYGRSVLAPARWRIPAEALPGPDTAWPDWARAM
                     TDLRARLRLPTTVSVGTEDRRLRLDLDEPMSLALLRAHLDGAGEAAVVSEAAGPADHGW
                     FGRRAHEIVISLAATTQAARAPAAVTVPGPLSLVRREDGILPGALHLVGCEDGVLPGAR
                     VLFAKLYGHPGVVDTILTKHLPELLETWDEPPMWWFVRYRDPRPHLRLRLHLAGRHDYG
                     PAAARVGAWAADLRGRGLVGDLVLDTYHPETARYGSGEVLAAAEAAFAADSAAVVAQLA
                     ALSAARQVHPHALTAASLVDLTAALAKDQAAGARWQIEHPPSGPAPANDRAVVRQAVGL
                     ADLSEDRAALRAIQGGPRIVAAWQDRRRAMAAYMDRLAADAPHLSESAVVESFMHMHHL
                     RALGIDRDVERRCRKLARAIALSFAARHDAAPYDGAPGDAAPGDDA"
     misc_feature    complement(10004..10022)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.02"
                     /tool="antismash"
     aSDomain        10544..10822
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_KLK06_RS12140_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.60E-19"
                     /identifier="RREFam001.1"
                     /label="KLK06_RS12140"
                     /locus_tag="KLK06_RS12140"
                     /protein_end="274"
                     /protein_start="181"
                     /score="59.6"
                     /tool="antismash"
                     /translation="VVVNDLAFVRGERLVVPWQPHAGDPARSELSEVSVRHGPAVRTVM
                     DLAQGPIQIGELIDGLAAAFPGARVPAIEVMVAELVTCGALITSLRPP"
     misc_feature    12995..12997
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13142..13144
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13325..14119
                     /locus_tag="KLK06_RS12145"
                     /old_locus_tag="KLK06_12130"
     CDS             13325..14119
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020604.5"
                     /locus_tag="KLK06_RS12145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12130"
                     /product="Stf0 family sulfotransferase"
                     /protein_id="WP_214635448.1"
                     /transl_table=11
                     /translation="MVAPFFRTNSREFDFPPFAGLPPIRYVLAAAPRSGSNMLVRTLWH
                     TGRAGFADGYLTDTHVLDYFERWGFDTADPAGLVKGYIAKLMTCRTSPNGVFGIKVHGE
                     HLQGLEVDLDELLMSPRYIWLRRRDRLRQAISYVLARQTGIWIVDGIYLSTSRALSEPQ
                     YDYAEIRRHLQHLDGETRVWQQYFDRHELVPHIIFYEDMLADYPETVLGCLRYLGVDPP
                     DSLPEPGIKRQSGEITERWLDMFERDSARYGDGAAIVKESLS"
     misc_feature    13580..13582
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14100..14747)
                     /locus_tag="KLK06_RS12150"
                     /old_locus_tag="KLK06_12135"
     CDS             complement(14100..14747)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="KLK06_RS12150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12135"
                     /product="DUF5825 family protein"
                     /protein_id="WP_214635449.1"
                     /transl_table=11
                     /translation="MSEPLACVPLTLWKDRDPAAMRVPGMYAGRVDVTGDPVATVSRVA
                     EDGVQLAQLDDTVDLDDADGAAAVAALTVIRELTSHGIAVDWTVRMPADPAGWRPLSHL
                     HPPAAVYAGSAGDGIAAEWRDSFHIAKCGYRLGPGFIEIRDRRTGSFKRLVIRNPHREE
                     AIAPLLRGVRATTLSPAVTERYLRADLLHQVGGFVWWTPYRIRRWPLSSTIP"
     gene            complement(14744..16678)
                     /locus_tag="KLK06_RS12155"
                     /old_locus_tag="KLK06_12140"
     CDS             complement(14744..16678)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03975.1"
                     /locus_tag="KLK06_RS12155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12140"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_214635450.1"
                     /sec_met_domain="TIGR03975 (E-value: 2.3e-176, bitscore:
                     583.3, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHIVLVDMPWSSIDAPSLSLGVLKRRVLDVFPDDDVDVIHANLDY
                     IDWVHAHVGFTFEEYDTFVSSYFSGHSEWIFSAALNERPRWKVAEYAEFLGGSVPERML
                     AKATELHELAPLFIEETADRITAMKPDVVGFTATFAQNAAALAAAREVKKRAPDAVTVF
                     GGPNCEGPQGAAMHRNFPYVDFIVRGEGELVFPQLLSAIRAGSGAGGDVSGIAGLCWRG
                     PHGESVTNPVEARPLPPEALVPPDFGDYFDQHARSVAGTWVEPRLTVEGSRGCWWGEKH
                     HCTFCGLNGSLMQFRSKDPGRFVDEILTLVERHRVLDVWVTDNILDMTYLSSMAPRLQE
                     SGYDLRIGYEIKSNLRRDQLETLRAAGIDYVQPGVENLSSRVLTLMDKGVSGCLNVRLL
                     RDSETVGINLNWNYLYGFPGESEADYDSVIDQVPALHHLMPPSNATRIKVERFSPYFDR
                     PELGFGELHPAAQYRHIYDLPESELADLVYVFDSPRRGIDAGCLDRLRGAVADWKDAYS
                     RSRLTHCDLGDHIVLVDTRPGFSWHLLDLTEPLEVTVFRLLDTPHSPAGLTRKAAARHD
                     GVTEDLIDALLARWRALGLIFCDAGQAVHVAPAVANQDLMRLDGENLSRGEPLVPALAA
                     MAVPVGMPR"
     misc_feature    16685..16699
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.57"
                     /tool="antismash"
     gene            complement(16712..17467)
                     /locus_tag="KLK06_RS12160"
                     /old_locus_tag="KLK06_12145"
     CDS             complement(16712..17467)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS12160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_12145"
                     /product="hypothetical protein"
                     /protein_id="WP_214635451.1"
                     /transl_table=11
                     /translation="MSTPVVRSLDGEQLADLIMRLLLDGRLRERLATEGAAAVAVDAGE
                     LECLETIDLDELDAAARRFRSNIWRLGTGGSLASTFPRSVSLFAAVGVGEAELLDGFLG
                     SPCFARFRLIPYSGVGVSVEEAFASFLRDLAEPRPVAAILRETVDHELMIALFTALACE
                     QPLSFVIESEGIVETDRGHAALRRYAPAALASWGEAAAGDGAVPYAYFATPAGVTRGVV
                     SERVAAAFAAIPTAESDAARRALSRRGLW"
     gene            complement(17464..18510)
                     /locus_tag="KLK06_RS12165"
                     /old_locus_tag="KLK06_12150"
     CDS             complement(17464..18510)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016970.5"
                     /locus_tag="KLK06_RS12165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12150"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /protein_id="WP_214635452.1"
                     /transl_table=11
                     /translation="MTTDITTGTRQAVAAGRAGAARLGFGLLMDMPWGGGALGRRGVGF
                     VETDDGGDITPRVRAFAERHGADFAYAAFAYQPRSRATPRVADYVRAYDRFFEALPAGL
                     DRAFHQTEFNMGTPEPYDRRPAAEYTNELAARYGFRWVVEDLGIWNLRGCPLPYPLPPP
                     LTEPGLEIATRNVAETAGLLELPLHVEFPGFTEGGSFVLGHLDAFAYFTRLADDADVQV
                     TLDVGHLLSYQWLRGRTGRHMVDDIEALPLGRCRELHLSGCQIVKGKFRDLHHGVLLDE
                     QLELTEYLLPRCPNLLGVTYEDPMFRDDGRLVEKSRRNYGRLKTLVAAWRDGTAGQDVA
                     ARQDGAAR"
     gene            complement(18507..20588)
                     /locus_tag="KLK06_RS62270"
                     /old_locus_tag="KLK06_12155"
     CDS             complement(18507..20588)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="KLK06_RS62270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLK06_12155"
                     /product="radical SAM protein"
                     /protein_id="WP_214635453.1"
                     /transl_table=11
                     /translation="MPFGQEAGGEGVDVLLIFPPQTEARFFPYLSLPYLSGHLRRRGRR
                     VHQADLNIALLHDLLGHPELLGDVVRDQPDSGAGAWYRRAMADVVAGYVDELRAHVLRK
                     EPPGELGPARAVRLAHHAIELLVRDTFLVRTWRDLAQLDGAAQQAALLPPAASGMPIER
                     LYGMVEALLVRHRPRVVGLSVAFFSQLAPALLIAAWVRRLRPDAKICLGGQQVMIRHEE
                     LARLPGVRAAVDALCWTAGEQPLERWLDALDGNAPEDAVPGMIWLPRAAPARRSEQPVT
                     LRFHDLGPPDFSGLPVRSYLNETMEVAIISCVGCYWGRCAFCSYGNRSLAPGAYQQGTV
                     RQIADAVQAVVRDTGAEFVSISDENTNLRLIVKAMREVRDRGVKVGFGVRSRLDATLAD
                     PAFCRSLAEVGCELMSVGYEGTSQRLLDLMDRGVRAADYQRIVENVASVGIVLRFSVMG
                     YVFDETDAEFEESLRFLAANQERIGIDALELMVSEPGSRLARDPDGFGLSLDTSGALAG
                     NPELSYLSGRVGHPLTVLDGPTRAQALDRLVRVFHTVRPGKATAILPRRTASSAGSRVA
                     AVRAVKPYPWVRTVPARVDVAGFPDAKGRDTGAAANGTKDAGGDGRIVLADLVWERFYA
                     LPRRDVEQRADGLLEARTAHGRRLLASLVEVTAGTDQTGAVRWEAPAVAGGEAVRRPT"
     gene            complement(20612..20770)
                     /locus_tag="KLK06_RS12175"
                     /old_locus_tag="KLK06_12160"
     CDS             complement(20612..20770)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS12175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_12160"
                     /product="hypothetical protein"
                     /protein_id="WP_214635454.1"
                     /transl_table=11
                     /translation="MAAVKPEMLIDDEFTELDQLEVIESSELKLSGSYHSYTYKAAEDT
                     GDLPARA"
     misc_feature    20923..20937
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.1"
                     /tool="antismash"
     gene            21204..21392
                     /locus_tag="KLK06_RS12180"
                     /old_locus_tag="KLK06_12165"
     CDS             21204..21392
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="KLK06_RS12180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="KLK06_12165"
                     /product="hypothetical protein"
                     /protein_id="WP_214635455.1"
                     /transl_table=11
                     /translation="MEQPGRGQSGGLPAGPAAAGQWADLENDAKTTTLTARPKVYDLKM
                     EQTVRPCCWPTSRLSTI"
     misc_feature    22170..22184
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: medium, score: 18.58"
                     /tool="antismash"
     misc_feature    22260..22278
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 20.23"
                     /tool="antismash"
ORIGIN
        1 gccggccacg ggtcagccag agcaggacga gcgccaccag cgcggccagc aggccgaacc
       61 cgatcatcaa ccggaaaccc cagtaggcga ccggaatgta gggacggtag tcgcccgggc
      121 cgaacctccg ctcgtacgcc gcctggaggt tgttgatgcc ctcgaccttg ccgtcgaacg
      181 agccggtggc gagctgtgac agcaggttcg ggatctccag ttggtagatc ggcttggtgc
      241 cgtccagcgt cccgatggtg aacagggaga acggcgcggg ctgccgcgtc tcgtagagcg
      301 cctcggcggc ggccatcttc atcggctggg tctgcgtcat gatcttgcca aggatgtcgc
      361 cggagacaag agtgcccaga gcgcccacca gcaccgcggc aatgccgagc cgcagagacg
      421 gtctgaacac ctcgagatcc cgctttctag ccagatgcca ggcggaaacc gccatcagga
      481 tcaccccacc ggccagccag cacccgaaga ccgtgtgcgg aaaggtggcc agcaccacct
      541 tgttggtcag cacggctccg aagtcgacca gctcggcacg ctgattgacc ttgaaaccca
      601 caggccactg catgaacgag ttggcggcca gaatgaagta ggcggacagc atcgtcccga
      661 acgcgacgat ccagatgcac gcgagatgca ccctcttcgg cagccgaccc cagccgaaga
      721 gccacagccc cagaaacgtc gactccagaa agaacgccag caacgcctcc agcgcgagcg
      781 gcgcgccgaa gatgtcgccg acgaacctgg aataggtgct ccagttcatc ccgaactgaa
      841 actcctgcac gatccccgtc accacgccca tggcgaagtt gatcaggaag agcgtcccga
      901 agaacttggt ggcgcgaagg taggcgacct taccggtgcg cacccacgcc gtgttcagaa
      961 tcgccaccaa cagcgacatc cctatcgtga ccggcacaaa caggaagtga tacaccgtag
     1021 taaccccgaa ctgccagcgc gcgagctcca aggcatccac gactcttact gtaagtgtcc
     1081 gagtatgcac gccttgtcat gacgcgccgc cagtcgtcgg gcaggatgct gacagtccag
     1141 gtcgcatgac gagctcgaac acctccagca tcatgtcgcc gcctcaggcg gtctgacggg
     1201 tgccggtgat ggggatggtc atcatcggcg ccttcgccgt gccggtcatc gtgtcgccct
     1261 cgaccgagac ggtgaacgtg accttcatct tgaacggtga ggtgagagtg gcgacgaagc
     1321 cgatctcggt gccgtcgacc tgcccgtcct ggatcggggt gccgtcgaag gctccggtca
     1381 gggagccagc ggtggcggcg agccgcagtt cggcctgctg ccggccgcgg ggcgtgcgga
     1441 agctcaccgt ccaggtgccg tccaccgccg tggcacgcga ctgcccgcgg cggtaggcgg
     1501 cggcggcctc ccggtacctc tggtgttccg cctcgtggtc ggggaagtcg gcggagccga
     1561 agtcgcccga agcgaagaac gagtcgagtc cgccgttggc ggcgacggcg tgctgtcccg
     1621 agcgaggcag catgacggcc tcgtatcggg tgatcgcctc gtcgagagtg gcctcctcgg
     1681 cgatggcgtg ggcgagctcg gctccgtcga gcatggcgag gttgaccccg taccccccga
     1741 aaggcgccat caggtgcgcc gcgtcgccga gcagtgtcgc gccgggcgtg tgcgcccagg
     1801 tgagcggggc gggaagggcg tagatcgggc ggttgaggta gccgccgtcg acgtccgtga
     1861 ggaagggcag catctcctcg gcccagccgc tgaactcctt gagcaggaac cgtcgtacgg
     1921 cgcccgcgtc gcccaggtcg acgccggcct tgccgtgcca gtcgaggtcg gtacgcaggg
     1981 ccaggtaggc gcggatgtgg ccgttgctgt tgcgctggcc gatgatggcc cggccgtcgc
     2041 cgtcattggc gaacagatgg ccgttcccga cgagtttcgc gatctgggga tgacgggttt
     2101 ccacgtcctc aaaacggacg tcgaggaacg agacgcccgt gtagtcaggc gtggcgtcgc
     2161 tcaggagcgg ccggacccga gaccaggcgc catcggcgcc gatcaccaga cccacctcgg
     2221 cggtgacgcc gttgccgaac tcgaggcggt gcccgccgtc gccgagcgga gtcgcggtga
     2281 ccagcttgtg tccccagtgc acggtgccgg gccgcacgtg ttcggcgagc atggcgcgga
     2341 gctgcccgcg atcgatctcc ggggcggcgg tgtcgtcctg gtcggggacg aacgcgtcga
     2401 gcacggtgcc gtgctggtcg agccggctct tggcctgccc ttcgagccgg gcgagcttca
     2461 tgaactcctc gaacaggccg gcgtcttcca tggcgatctg tccggtgtcg gcgtgcaggt
     2521 ccagggtccc gccggcgtca cgggcttcga cggaggcgtc ggcgtcgtac acggtgacgt
     2581 cgatgccgtg tccttgcagg actcgggcgc acatcaggcc gccggggccg gcgccgacga
     2641 tggcgatgcg tacgggggat ttcatggcgg agtccttact taacgggcgt tcgttcagca
     2701 gtgttgacag taactgaacg ggcgttcgtt gagcaagtac actgaggcga ccgaagggac
     2761 catccatgtc gacgaacacg ggaagtgacc ggcgtacggg ccccgagacc cgcgcggaga
     2821 tcctccgcgt cgcgctgcgg ctgttcacgg agaagggcta cgagggcacc tcgacccgag
     2881 acatctccag cgcgctcggg atgacgaaat cctcgctgta ctaccacttc cagaacaaag
     2941 aggagatcgt ggcgagcctc gtggaagggc gccggcacga actcgacgac ttcatcgagt
     3001 ggctcgccgc gcagccgccc acccccgatc ggctggagaa ggcggcgctg cgctggctac
     3061 agggcaccac tcccgaacat cttcaggcca tgcttttcgc gcaggccaat cagccggtca
     3121 tgaggcggct ggcggaaggc ggccgggata tccggtcgaa cttcgaccgc gtcatcgacc
     3181 tgctcgtcga cgagggggcg agcatggagg accgcctctt gacgcgcatg gtcttcgaca
     3241 ccgccggagc cgcgctcctg tcggcgcggg gcacggaggc cgacccggac gatgtcatcg
     3301 ccgccgcccg gcgcgcgacc accgcactcg cccgcgcgac cacggaagcg accaaagagg
     3361 cgctctgaga gcggctgccc cgtgaagctc tcatcgcccc tgcggggaaa catgcgggac
     3421 ggacgctcct tccaagagcg tccgtcccgg tgaagcagat cgtgggtggt cagtcccagg
     3481 tcgggaggta ctccgcgggg tagcgggcgc cgaagccgcc ggccgggagg atgtcggcga
     3541 tgcgcttcag atcggcgtcg tcgagggtga ggtcggcggc gccgacgttc tcttccaggc
     3601 gcttggggtc gcgggtgccg gggatgggga cgatgtcgtc accctgggcg aggagccagg
     3661 ccagggcgag ctgggcgacg gtggcgtcct tggtggcggc caggtcggcg agccggcggg
     3721 tggccgccac gttcttctcg tagttgccgg gctggaagcg ggcgtcccag gtgcgcatgt
     3781 cgctggagtc gtactcggcg ccgggcttgg cctggccggt gaggaagcct cggccgagcg
     3841 gcgagtaggg gacgaacccg atcccgagct cgcgcaggac ggggaagagg atctcgacct
     3901 cccgctcgaa cagactgaac tcggtctgca gcaccgacac gggttgtacg gcgtgcgcgc
     3961 ggcggatggt gttctcgccc gcctcgctca ggccgaagta acggaccttg ccggcctcga
     4021 tgaactcctt gaccgtcccg gccacgtcct cgatcggcac gtcggggtcg acgcggtgct
     4081 ggtagagcac atcgatgacg tcgacgccga ggtagcgcag gctgttgtcg acgacctcgc
     4141 ggatgtgctc gggacggctg tcgacaccgc cctgccgggt gccggtgaag tcgaacccga
     4201 acttggtcgc gatgaccacc tcgtcccgta cgggtgcgag cgcggccccg acgatccgct
     4261 cgttctcccc ctgtccgtac agctcggccg tgtcgaagaa cgtcacaccc agctcgtggg
     4321 cccggcggac cgtcgcggcc ccctcctgct tgtccgaggg cccatacgcc agggagatgc
     4381 ccatcgcgcc gtatcccagc gctgacgcgg tcaggccctg ctgtccgaga tttcgctgct
     4441 gcatggtgct cgacctgctc tttctccgca tgttagagcg cacttacata aagtaagagc
     4501 actctaacat cgagaagagg ggagaatcgt tcgccgtgag cagtcccacg acaccgcgac
     4561 gcggctacca tcacggcgac ctgcgtgccg ggttgatccg cgagggcata gccctcctgg
     4621 ccgagacggg cgtcgcgggt ttctcggtgg ccaaggtcgc cgtccgcgcg ggcgtgtcgt
     4681 cggccgcgcc gtaccgccac tttcccgatc gtgaggctct gctggccgcc tgcgcggccg
     4741 ccatcctcgc cgacatcacc gacctgctcg ccgcggcggc cgagcaggcg ggacccgacc
     4801 cgctcgaccg gctcgccgcc accgcgggcg cctacacgcg ctatgtcctg gagcatcgcg
     4861 ccggcatcga tctcatctac tcgtacgaat tcagcggccc ccaccacccg accgtccagg
     4921 agcagagccg ccgcctcacg ggcgctctca tggatctggg ctcagccgtc ctgcccgccg
     4981 acgtctcctg ggccgacacc gccgacttcg tgtacgtcca cttgtccacc acgcacggct
     5041 acgccaccct gctcgtgaaa ggcacccgcc cgccccagga catcgacagc cacgccgctc
     5101 gcgccgtcac cgccgcccgc gaccacatca ccggatacct ccagcgcctg aacaaccgtg
     5161 agaccgcata gggtcacctg ccgacctcgc gagggcctga tcggcgcttg cgggatcagg
     5221 ccacacgatt gacgacgttg aaggcgtcaa ccttcggccg gacgctctcg ggaactgttg
     5281 atccgcagcg cttcggcgag ttggtcttcc aagatgacaa tgcggcaggc agcgtccagg
     5341 gcggtgccct ggtcgacgag ttcccgggcc ctggctgcca gacggagctg gtagcgggag
     5401 tatcgacggt gtccgccgcc ggagcgtcgc ggctcgatca gtttggcgac gcccagtgcg
     5461 cgcaggaacg cgggggtgac gccgagcatc tccgcggccg cgcccatgct gtaggcggga
     5521 tagtcctcat cgccgaatct gtcttcggcc ttgctttgag cgagcgtggc gtcgttgcct
     5581 tctgggtgac tttgatccat aaataccttc cgacatgcgc acagggggcc ccggcgcgtc
     5641 ttgcgccggg gccccgaaga ggttcaacac catctatcgg ccatgtggcc gaccttctgt
     5701 cgtccgtatc agccgtatat gacggcgccg atgcggggat cgcggattct tgaccgtaga
     5761 ccaccttccg atctgtggaa ctgcggtgcc cgagcggcgc gaaaatcagc cggcaacggg
     5821 cgatcccgat ggcgttcaac actcccttct ctcaagcgaa cttgctcttc ctacttcacc
     5881 tatggcagcg cgtccacggt cagggcccct taccactgcg ctggccccgt cacgtccgac
     5941 cttctgccat caccttctgc ttccatccag ctcatccggg cagtgcgtcg tgttgctggt
     6001 ttctcatgcc cgtgtggatt cgttccttgc gatgtcagaa acattagcgc ccacatccac
     6061 gaatgtctac cctgaccgct acagattttc gatcctggct gggttagctg tggcctcgcc
     6121 gtcagggcgc tatggcgtcc ccagataggt gtcgagcgcg cccgcgcccg tcagcatcgc
     6181 caggccccgc gtcgtcagcc ggtcgcgcca ctcccgcatc gtcgcctgca gcggctccgg
     6241 cccgcccgcc gcccgcaccc gctccagcac ccgcgcgatc tgctccagcc cgtgcccgcc
     6301 ccgccgcaac tggtgggcca gcagtacgtc acgctcgtcg gccgaggtgt agacgcggta
     6361 gccggtgcgc gggtcgcgcc ggggcacgat cagcccggcc cgctcccatt tgcgcaacgt
     6421 cgccggccga atgccgagcc tgcgcgccag cggcccgata aacgtcacac ccgacgccgg
     6481 ctcacgcgcc gacgccaggc cgcgcagcga ctcctggtca cgcggtggct tcagctcacg
     6541 cggcgactcc cggtcgcgcg gcgacgccag gtcgcgtagc gcccgttcca cggcctccag
     6601 cgtgtgccgg tcgccggcca actgcgcgtg gctctcgtcg atcagccgca gcgcctcctc
     6661 gaccgcgccg ccgttcacgg cccgcatgat cgcccccgcg gtcgcgtggc cgtgcgcggg
     6721 gatcaacgcc aggaacgtcc gcaacgccgc cgcatggcgc ggagcatagg cgcggtagcc
     6781 gtgcggcgac cgctcggccg gcggtaggat ccccgcctcc tcatagttgc gcaccgcctg
     6841 cgtggacagg ccgtgctcac gcgccagatc gatgggtcgc aaccgcattt tgaaggtacg
     6901 tcctcgtcaa cagccggaaa tgccgccaaa gtttacacag aaggttcaac gatacagtca
     6961 aaggaatgac gacctcgatc caggacgccg cccatccctt caccagcggc gccctcaccg
     7021 cgctcctgcc ccccgccacc cgcctgctcg gcctcggcga gcccacccac ggcgtcgaag
     7081 ccttcctcga tctgcgcaac gagctcttcc gccacctcgt cgaacacgag ggctaccgct
     7141 cgatcaccat ggagagcgac tgcctggcgg ccctggccgc cgacgcgtac gtcaccgacg
     7201 gcatcggaac cctcgacaac gcgatgagcc aggggttcag ccacggctcc ggcgcctcat
     7261 ccgccaaccg cgagctcctg cgctggatgc gtgcctacaa cgagcagcgt cctccgtacg
     7321 agcggctcca cttctacggt ttcgacggcc ccctggagat cagcggcccc gccggccccc
     7381 gtccagccct gaccgcactg cacgactacc tcgccgccca ccttgacctg ccctggagcc
     7441 gcgagaccct cgacgagctg ctcggccccg accagcgctg gaccaacccg gccgcgacaa
     7501 cggatcccac ccagtccgtc ggccgcaccc ccgaggccaa ggaactgcgc ctgatcaccg
     7561 acgacctgcg tacgctactc accgcgcacg ccccccacct gacggccacc acctcccccg
     7621 acgacctgtg gcgcgccgac ctgcacgccc gcaccgccgc cgggctcctg cgctaccacg
     7681 ccggcatagc cgacaccgcg cccacccgcg tcggcacgct catgcgcctg cgcgatgcga
     7741 tgatggccga caacctcgac gccatcatcg accgcgaggc ccggcgcgga cccaccctcg
     7801 ccttcgccca caaccgccac ctgcagaagg acaagagccg ctggctgctt ccggagggct
     7861 ggggcccact ggggggccgg acgctggagt ggtggagcgc cggggcgatc gtcggcaccc
     7921 gcctcggcga ccagtacgcc ttcgccgcca ccaccttcgg cacccgcggc tccgacgtac
     7981 cccatcccga caccctcgaa gggctcctgt cgactctccc cgacgcccgc gccgtcatcg
     8041 atcccggcgg cctagcggcg gccctagacc ggaagccaac gccccgcgtt ccggccgacc
     8101 acacctactt cgccctcgac ccggccacca tcgaccagtc cgacgccatc gtcttcgtca
     8161 aggaaatctg agccacccac ggtggcgacg tgggcatcgg gaggctacgc ggcggtgatc
     8221 caggccgggc tccttgccgc cgacctggcc cgccgcgccc tccgctctgc cggccgacaa
     8281 ggcgaaccga tcggcggcgc gggaggccct ggaggagttc gacgctcgct aggccgtcgc
     8341 cgagatccag ggtttcggca ggcctcagct gacgcgggtc accgcccctt gcccgtgaag
     8401 gagcactgct cgcccgttcc caggagcctc ttgacgaacc cccagggcgg gccgttgtcg
     8461 atgaggcaag cctggtcgac gctcatggcc acgccgggca gttcactcgc ggcctgggcc
     8521 acggccgaag agtccgcacc cgccctgatc ctggcgcgga aggactcggg catgtccgtg
     8581 ggagttgtcg ccttcaggag ttcggggttg tcctcgtact ggcgacggaa gttctcccag
     8641 gcctgctgcc ggccctcaaa ccggacgctc tccacctcag gccaggcctc cagcgcctgc
     8701 tggagattct tccgttctgt cgtggtgatc tcgccgcccg cgcagctcgc aaaggagtcg
     8761 ccggccttgc agaggaagac cgcgacctcg ggcccttcag ccgacaccgc gccgctcagt
     8821 gacatggcga cgatgttctc ctgcggctcc aagaaggagg tggcgaggcc tgcgactgcg
     8881 agggccgtca cggcgacggt cagggtggcg gcggcgaccc tgaccaggcc gcctccggag
     8941 ctgcggcggg gccgcggggc tggcaacgga cggtcatcgt ccccgacaat ctccgcgcga
     9001 gccgccatgg cgtcgcggag ccgctcttca atgctgttca tgcgttgtct tccagttcgc
     9061 gaaggagccg ggccagggct cgggcggtca tggacctgac ggtgctctgc ctgacgcgca
     9121 tggcctcggc gatctcagcg tcggacaggt cgaggtagtg gcgcatcacc agggcctccc
     9181 gctggcgccg gggcaggcgg gccagtgcgc gcagcacctc ccgccgcgac tccccgatca
     9241 gcgcggcggt ctccgccgag tcggccaggc cggcgaccgg ctcgacccgc cgcagcgcga
     9301 ccgcccggcg gcgaaggacc gaccgggaac cattgagcac gcacgtcctg acataagcaa
     9361 tcgtcgtgac ccccggccgc cacatgctat gaagccgagc gaacacgtcc tgcaccacgt
     9421 cttcagcagt ctcttggtcg ccgacgagca gcaccgcgaa ccgcacaaga ctgagccgat
     9481 gctggcgata gaaggcgacc agctcagcat caggggatgc gactggcgga gccgacttcg
     9541 ccagccgcaa aatttcacta tccatggtct ataaacgcgc acccctaccg atccgctgct
     9601 cctccacccc gaaataaccc ggagaaagat tcgtccgccc ctgccgagtc gtctccgccc
     9661 ccagtacgtt caccctcgcc gtccgccagc gcgatcaccg cgaagcgttc gggcaggtga
     9721 tccgcatcat cgtcgccgcc ccagttcgac gcggggccgc taccgcaagg gcaacaccgg
     9781 ccgccccgcg tcggcaccca gcccatgccc gtccccgacg acctgtccgc cgtgcttccg
     9841 cggagcatga cgaagacgac ctcgccgctt tgtctgactc cccctgtgtg tggtgatcgt
     9901 cttgcgggac agaacggggc acgtgcgaca ctcgggatgg cggccctgcc gagccgtccc
     9961 ggacgccgcc gtcagcctgc tggacgtggg aggcatcagg gtgaatgcgc agcgttcgca
    10021 gccgtaccgg caccttgacg cggcactgat ccgcgccacc gcgcacccgg gcgaaccgga
    10081 tctcccccca tggcccgaac aggacggcga ggccggcgcc gaacggtggc gcgagtggct
    10141 cgcccaggtc tgggcgcgag attccgtggc ggcggccgtc tccatggcca gccctgccct
    10201 ggcgtcccag atcgaggcag tgtgcacagg ccgccgcccc cgcgccggcc gcctccggcg
    10261 catggcgctg tcactggccc ggtacctggt acggatgcgc gcccgcgcca cgcctttcgg
    10321 gacattcgcc ggcgtgaccc cactccgttt caacacaaca cagacaggcc ggaccgccgt
    10381 cccgcaccct ggcgcgacgt tggcgagcga cgttccgcac actggcgcgg cgctgatggg
    10441 ctggaccggc gtcccgcgaa cgaggacgac ggcggacggt gtgtggctgg ctgcggtgat
    10501 cgcccggctg gaatcgggcc cggagctgcg gcgtcgcctg cctgttgtgg tgaacgatct
    10561 cgcgttcgta cgcggggagc ggctggtggt gccctggcag ccgcacgccg gcgacccggc
    10621 tcgcagcgag ctgtcggagg tgtcggtgcg gcacggcccg gcagtccgga cggtcatgga
    10681 cctggcccag gggcccattc agatcgggga gttgatcgac gggctggccg ccgcgttccc
    10741 cggtgccagg gttccggcga tcgaggtgat ggtcgcggag ctggtcacgt gcggggcgct
    10801 gatcaccagc ctgcgtcccc cctcgaccag ccccgacggg ctcgcgtatg tactggaccg
    10861 gctgggagac gtggcggcgg acgcgttcgg tgaggtcacc ccgctggtcc gggagctgcg
    10921 cgcgatccac gaggggctgc gagcggccga ccacgcgacc ggcgaggccg ccgtgcgggc
    10981 caggcgagcg gtcgccgatc ggatgcgagc cgcgctgccg gtcgaggtcg tccagccact
    11041 caaggtggac ctgcgactgg acggcaccgt ggtactgccg ccggaggtgg cggccgaggc
    11101 cgagtccgcc gccggggcgc tcctgaggct gacgccgcat ccggcagggc acccggcctg
    11161 gcgggagtac cacgtcaggt tcctggaccg gtacggagcc ggcgctgtcg tcccggtcga
    11221 gcagctcgtc gacgacacgg cggggctcgg gttccccgcg cactacgggg agccacggca
    11281 gccggccgag cccctgtcgc gcagggatca gcggctgctg gcgctggcgc agcaggcggc
    11341 cctggacggt gcgcgggaga tcgtactgga cgacgccacg atcgagagcc tggccgcgga
    11401 cggtatggac gacgccgcga tcgagaaccg cgcgcgaccg ctcccgtaca tggaactggt
    11461 ggccgaggtg tgcgcatcca ccgccggcgc gctggccacc ggcgccttca gcatgacggt
    11521 gctcgccgtc gacggcacgg cggcctgcct gagcggccgg ttcgtcgaca tgctgccgga
    11581 tggggatcgg cggcggatgg ccggtttgta cgatcggctg ccggtttcgg tggacggtgc
    11641 cgtgccggtg cagttgtcgt tcccggcccg gaacgcccgt acccaggaag tcgcccgcac
    11701 cccactcctg ctgccggagc tgatcacttt ggccgagcac cgcgccgact cgcccgggcg
    11761 gatcccctgg cgggatctgg cggtcaccgc ggacaacgac cggatgtacc tgctgtcgcg
    11821 gtcccggcgg caggtggtgg agccggtgct gaccagtgcg gtcgcccggc gggccatgcc
    11881 gccgatcgcg cgcctgctgt tcgagatccc gcgtgctcgg ggcgccgtgg tgtcgccgtt
    11941 ctcctgggga gcggcggcgt gcctgccgtt cctgccgcgg gtccgctacg gccgcagcgt
    12001 gctcgctccc gcgcggtggc gcatccccgc tgaagccctg cccgggccgg acaccgcgtg
    12061 gccggattgg gcgcgggcca tgacagacct gcgtgcccgc ctgcggctgc ccaccactgt
    12121 gtccgtgggt acggaggacc gccgcctgcg gctggatctg gacgagccca tgagcctggc
    12181 gctgctgcgc gcccacctgg acggcgccgg tgaggccgcc gtcgtgtcgg aggcggcggg
    12241 acccgccgac cacggctggt tcggccgccg cgcgcacgag atcgtcatct cactggccgc
    12301 caccacgcag gccgcccgcg cacccgccgc cgtgaccgta ccggggccgc tgtcgctggt
    12361 caggcgtgag gacgggatcc tgccgggagc gctgcacctg gtcgggtgcg aggacggggt
    12421 cctgccgggg gcgcgcgttc tgttcgccaa gctgtacggg catcccggcg tggtcgacac
    12481 gatcctcacc aagcacctgc ccgagctgct ggagacctgg gacgagccgc cgatgtggtg
    12541 gttcgtgcgc taccgcgacc ctcgcccgca cctgcggttg cgcctgcatc tcgccggccg
    12601 ccacgactac ggtccggccg ccgcccgggt cggggcgtgg gccgccgacc tgcgcggccg
    12661 tggcctcgtc ggggacctgg tcctggacac gtaccacccg gagaccgcac ggtacggatc
    12721 gggagaggtg ctggccgccg cggaggccgc cttcgctgct gactccgccg ccgtggtcgc
    12781 ccagctcgcg gccctgtccg cggctcgcca ggtacacccg cacgcgctca ccgccgcgag
    12841 cctggtcgat ctcacggccg ccctggcgaa agaccaggca gcgggggcgc gctggcagat
    12901 cgagcatccc ccgagcgggc ccgctcccgc gaacgaccgc gcggtcgtcc gccaggcggt
    12961 cggcttggcg gacctgagtg aggaccgggc ggcgttacgg gccatccaag gcggcccgcg
    13021 gatcgtcgcc gcatggcagg accggcggcg agccatggcc gcctatatgg accggctcgc
    13081 cgccgacgcc ccacacctga gcgaatcagc ggtggtggag tccttcatgc acatgcacca
    13141 cttacgggcg ctcgggatcg accgcgacgt cgaacgcagg tgccgcaagc tggcccgcgc
    13201 catcgcgctg tccttcgccg ctcgccacga tgccgccccc tacgacggcg caccgggcga
    13261 cgccgcaccg ggcgacgacg cctgacgggt tctgtctgat cgcctggtgc ggtggtaggt
    13321 atggatggtg gcgcctttct ttcggaccaa cagccgcgaa ttcgactttc cgccgttcgc
    13381 cgggctgccg ccgattcgct acgtcctggc cgcggcacca cgatccggca gcaatatgct
    13441 cgtccgcacg ctctggcaca ccgggcgggc cggtttcgcc gacggatatc tcacggacac
    13501 ccacgtcctc gactacttcg agcgctgggg attcgacacc gccgatccgg ccggcttggt
    13561 gaaaggctat atcgccaaat taatgacctg ccggaccagc ccgaacggag ttttcggcat
    13621 caaggtacac ggcgagcacc tacagggact cgaagtcgac ctggacgaac tcctcatgtc
    13681 gccccgctac atctggctgc ggcgcaggga ccggctccgg caggccatct cgtacgtcct
    13741 ggcgagacag accggcatct ggatcgtgga cggaatctat ctgtccacca gccgggcact
    13801 ctccgagccc cagtatgact acgccgagat ccgccgccac ctgcaacacc tcgacggcga
    13861 gacgagggta tggcagcagt atttcgaccg ccacgaactc gtcccgcaca tcatcttcta
    13921 cgaggacatg ctcgccgact atccggaaac cgtcctcggc tgcctgcgat acctgggcgt
    13981 cgacccgccc gactccctgc cggaacccgg tatcaaacgc cagtcgggcg agatcaccga
    14041 acggtggctg gacatgttcg agcgggacag cgcccggtac ggcgacggcg cggcaatcgt
    14101 caaggaatcg ttgagctgag cggccagcgc cttatccggt acggcgtcca ccacacgaac
    14161 ccgcccacct gatgcagcag gtccgcccgc aggtagcgct ccgtcaccgc cggcgagagg
    14221 gtcgtcgccc gcacgccgcg cagcagcggc gcgatcgcct cctcgcggtg cggattgcga
    14281 atgaccaggc gcttgaacga gcccgtccgg cggtcgcgga tctcgatgaa gccgggaccg
    14341 agccggtagc cgcacttcgc gatgtggaag gagtcccgcc actcggccgc gatgccgtcc
    14401 ccggcggagc ccgcgtacac ggccgccggc gggtggaggt ggctgagcgg ccgccagccc
    14461 gccggatcgg ccggcatgcg gacggtccag tcgaccgcga tgccgtggct ggtcagctca
    14521 cggatgacgg tgagagcggc caccgccgcg gcgccgtccg cgtcgtccag gtcgaccgtg
    14581 tcgtccagtt gggcgagctg gacgccgtct tcggccaccc gcgacacggt cgcgacgggg
    14641 tcaccggtga cgtccacgcg gcccgcgtac atgcccggga cccgcatggc cgccgggtcg
    14701 cggtccttcc acagcgtcag tgggacgcac gccagtggct cgctcatcgc ggcatcccta
    14761 ctggaaccgc catggccgcg agcgccggta cgagcggctc gccgcggctg agattctcgc
    14821 cgtcgagccg catcaggtcc tggttggcga cggccggcgc gacgtggacc gcctgacccg
    14881 cgtcacagaa gatcagcccg agcgcgcgcc agcgggcgag cagcgcgtcg atcaggtcct
    14941 cggtcacgcc gtcgtgccgg gccgcggctt tgcgcgtgag ccccgccggg ctgtgcggcg
    15001 tgtcgagcag gcggaacacc gtcacctcca gcggttcggt gaggtcgagc aggtgccagg
    15061 agaagcccgg ccgggtgtcg acgaggacga tgtggtcgcc caggtcgcag tgggtcaggc
    15121 ggctccgcga gtaggcgtcc ttccagtcgg cgacggcccc gcgcaggcgg tcgaggcagc
    15181 ccgcgtcgat gccgcggcgc ggcgagtcga agacgtagac gaggtcggcg agctcggatt
    15241 cgggcaggtc gtagatgtgc cggtactgcg cggccggatg gagctcaccg aaacccagct
    15301 cgggccggtc gaagtacggg ctgaagcgct cgaccttgat ccgggtggcg ttcgacggcg
    15361 gcatcaggtg atgcagggcg ggcacctggt cgatcacgct gtcgtagtcg gcctcggact
    15421 cgccagggaa gccgtagagg tagttccagt tcaggttgat gccgacggtc tccgagtcgc
    15481 gcagcagccg gacgttcagg cagccgctca cgcccttgtc catcaaggtg agcacccggc
    15541 tgctgaggtt ctccaccccc ggctgcacgt agtcgatccc ggccgcgcgc agggtctcca
    15601 actggtcccg gcgcaggttc gacttgatct cgtagccgat ccgcaggtcg tagccggatt
    15661 cctggaggcg cggggccatc gaggacaggt aggtcatgtc gaggatgttg tcggtcaccc
    15721 acacgtcgag gacccgatgc cgttcgacga gggtgaggat ctcgtcgacg aaccggccgg
    15781 ggtccttgct gcggaactgc atgagcgagc cgttcagccc gcagaacgta cagtggtgct
    15841 tctcgcccca ccagcagccg cgcgagccct ccacggtgag ccgcggttcc acccaggtgc
    15901 ccgcgacgga cctcgcgtgc tggtcgaagt agtccccgaa gtcgggcggg accagcgctt
    15961 ccggcggcag cggccgggct tccaccgggt tcgtgacgga ctcgccgtgc ggcccgcgcc
    16021 agcacagacc ggcgatcccg ctgacatccc cgccggctcc gctgccggcg cggatcgcgc
    16081 ttagcagttg cgggaagacc agctcgccct cgccgcgcac gatgaaatcg acgtacggga
    16141 agttccggtg catcgccgcg ccctgcggtc cttcgcagtt cgggccgccg aataccgtga
    16201 cggcgtccgg cgcccgcttc ttgacctcgc gggccgccgc gagggctgcg gcgttctggg
    16261 cgaaggtggc ggtgaacccg accacgtccg gcttcatggc cgtgatccgg tcggcggtct
    16321 cctcgatgaa cagcggcgcg agctcgtgga gttccgtcgc cttggcgagc atccgctccg
    16381 gcacgctgcc gccgaggaac tcggcgtact ccgccacctt ccaccggggc cgttcgttca
    16441 gcgccgccga gaagatccac tcgctgtggc cggagaagta ggagctcacg aaggtgtcgt
    16501 actcctcgaa cgtgaaaccg acatgggcgt gcacccagtc gatgtagtcg aggttggcgt
    16561 gtatgacatc gacgtcgtca tcggggaaca cgtcgaggac ccggcgcttg agcacgccga
    16621 gcgagagcga cggtgcgtcg atcgacgacc acggcatgtc caccaacacg atgtgcatgg
    16681 gtcttgcccc tcatcttcag gtcgtaccgg gtcaccacag gccacgccgg gacagcgcgc
    16741 gccgcgccgc gtcgctctcg gccgtcggga tggccgcgaa cgccgcggcc acgcgctcgg
    16801 acaccacgcc gcgggtgacg ccggcgggcg tggcgaagta cgcgtacggt acggcgccgt
    16861 cgcccgccgc ggcctcgccc caggaagcga gggcggccgg cgcgtaccgg cggagggcgg
    16921 catgaccgcg atccgtctcg acgatcccct cgctctcgat gacgaacgac agcggctgct
    16981 cgcaggccag cgccgtgaac agggcgatca tcagctcgtg gtccacggtc tcccgcagga
    17041 tcgcggcgac gggccgcggc tcggccagat cgcgcaggaa cgacgcgaac gcctcctcca
    17101 ccgacacccc gacccccgag tacggaatca gccggaacct ggcgaaacac ggcgacccga
    17161 ggaagccgtc gagcaactcc gcctcgccga cgccgaccgc cgcgaacagc gacacgctgc
    17221 gcgggaacgt ggaggcgagg ctgccgccgg tgccgagccg ccagatgttc gagcggaacc
    17281 ggcgcgccgc ggcgtcgagc tcgtcgaggt cgatcgtctc caggcactcc agctcaccgg
    17341 cgtccacggc cacagccgcg gcgccttcgg tggcgaggcg ctcccgcagc cgtccgtcga
    17401 gcagcagccg catgatcagg tcggcgagct gctcaccgtc gagggaccgc acgaccgggg
    17461 tgctcaccgc gccgccccgt cctgccgcgc tgccacgtcc tgccctgctg tcccgtcccg
    17521 ccacgcggcg accagcgtct tcagccggcc gtagtttcgc cgcgacttct cgacaagccg
    17581 accgtcgtcg cggaacatcg ggtcctcata ggtcacgcca agcaggttcg gacagcgcgg
    17641 cagcaggtac tcggtgagtt cgagctgctc gtccagcagg actccgtggt gcaggtcgcg
    17701 gaacttgccc ttcacgatct gacagccgga caggtgcagc tcacggcagc gcccgagcgg
    17761 cagcgcctcg atgtcgtcga ccatgtggcg gccggtacgc ccgcgcagcc actggtagct
    17821 gagcaggtga cccacatcga gagtcacctg tacgtcggcg tcgtcggcca gccgggtgaa
    17881 gtacgcgaac gcatcgaggt gccccagaac gaacgacccg ccttcggtga agccggggaa
    17941 ttcgacgtgc agcggcagct ccaggaggcc ggccgtctcg gccacgttcc gcgtggcgat
    18001 ctccaggccc ggttcggtca gcggcggcgg cagcgggtac ggcagcgggc agccgcggag
    18061 gttccagatg ccgaggtcct cgaccaccca gcggaacccg tagcgggccg cgagctcgtt
    18121 ggtgtactcg gccgcgggcc gccggtcgta gggctcgggc gtgcccatgt tgaactcggt
    18181 ctggtggaag gcccggtcga gcccggcggg cagcgcctcg aagaagcgat cgtaggcgcg
    18241 tacgtagtcg gccacccggg gggtcgcgcg tgagcgtggc tggtaggcga aggccgcgta
    18301 cgcgaagtcg gcgccgtggc gctcggcgaa ggcgcgtacc cgtggcgtga tgtccccgcc
    18361 gtcgtccgtc tccacgaacc cgacacctcg ccgccccagc gcccctccgc cccacggcat
    18421 gtccatgagc agcccgaacc ccagcctggc cgcgccggcc ctgcccgccg cgaccgcctg
    18481 cctggtccct gtcgtgatgt cggtcgtcat gtcggcctcc tgacggcttc gccacctgcg
    18541 acggcaggcg cctcccaacg caccgcgccc gtctggtccg tgcccgccgt cacctcgacc
    18601 aggctggcca gcaaccggcg cccgtgggcg gtgcgcgcct cgagcaggcc gtcggcgcgc
    18661 tgctcgacgt cacgccgcgg cagcgcgtag aaccgctccc agaccaggtc ggcaagcacg
    18721 atccgaccgt ccccgccagc gtccttcgtc ccgttcgccg cggcgccggt gtctcggccc
    18781 ttcgcgtccg ggaacccggc cacgtcgacg cgcgccggca cggtccgtac ccacggatac
    18841 ggcttgacgg cgcggaccgc agccacccgc gacccggcac tggacgcggt ccgccgcggc
    18901 aggatcgcag tcgccttacc gggccggacc gtgtgaaaga cccgcaccag acggtcgagc
    18961 gcctgcgccc gggtcggccc gtcgagcacg gtcagcggat ggccgacccg cccggaaagg
    19021 tagctgagct cgggattgcc ggcgagcgca ccggaggtgt ccagggagag gccgaagccg
    19081 tccggatccc gcgcgagcct gctgccgggc tcggacacca tgagttccag cgcgtcgatg
    19141 ccgatccgct cctggttcgc cgcgaggaac cgcagggact cctcgaactc ggcgtccgtc
    19201 tcgtcgaaga cgtaccccat cacggagaac cgcaggacga tgcccactga cgcgacgttc
    19261 tccacgatcc gctggtagtc ggccgcccgc acccccctgt ccatcagatc gagcaaccgc
    19321 tgggaggtcc cctcgtagcc caccgacatc agctcgcagc cgacctcggc gaggctccgg
    19381 cagaacgccg gatcggccag ggtcgcgtcc agcctgctcc gtacgccgaa ccccaccttg
    19441 acgccgcggt cgcgcacctc gcgcatcgcc ttcacgatca gccgcaggtt ggtgttctca
    19501 tcggagatcg acacgaactc cgcgcccgtg tcgcggacca ccgcctgtac ggcgtcggcg
    19561 atctggcgca ccgtaccctg ctggtaggcg cccggcgcga gagacctgtt gccgtacgag
    19621 cagaacgcgc atcgacccca gtagcagccg acgcacgaga tgatcgcgac ctccatggtc
    19681 tcgttgaggt aggaccggac cggcagcccg gagaagtcgg gcggcccgag gtcgtggaag
    19741 cgcagcgtga ccggctgctc ggaccggcgc gcgggggcgg cgcggggcag ccagatcatg
    19801 ccggggaccg cgtcctccgg ggcgttgccg tccagcgcgt ccagccagcg ttcgagcggc
    19861 tgctcgccgg cggtccagca cagcgcgtcc accgcggccc ggacgccggg cagccgcgcg
    19921 agctcctcat gccggatcat cacctgctgg ccgccgaggc agatcttggc gtccggacgc
    19981 agccgcctga cccaggcggc gatgagcagc gcgggcgcga gctggctgaa gaacgccacg
    20041 gacaggccga ccacgcgcgg acgatgccgg accagcagcg cctcgaccat gccgtacagc
    20101 cgctcgatcg gcatccccga cgcggcgggc ggcagcagag cggcctgctg cgccgcaccg
    20161 tcgagctggg ccagatcccg ccatgtccgg acgaggaagg tgtcgcgtac gagcagctcg
    20221 atcgcgtggt gggcgaggcg gaccgcacgg gccgggccca gttcgcctgg cggttccttc
    20281 cgcaggacgt gggcccggag ctcgtctacg tatccggcga cgacgtcggc catcgcccgt
    20341 cggtaccagg cgcccgcccc gctgtccggc tggtcacgca ccacgtcgcc cagcagctcc
    20401 ggatgcccca gcaggtcgtg cagcagggcg atgttcagat cggcctggtg gacgcgccgc
    20461 cctcgccgcc gtagatgacc gctgagatag ggcaggctca gatagggaaa gaacctggct
    20521 tcggtctgcg gcggaaaaat gagcaggacg tcgacaccct cgccgcctgc ctcctgccca
    20581 aacggcacga tctgcccggc cggcagtctc gtcaggccct ggcaggcagg tcgccggtgt
    20641 cctccgccgc cttgtaggtg taggagtggt acgacccgct gagcttgagt tcgctggatt
    20701 cgatcacctc aagctggtcc agctcagtga attcgtcgtc gatgagcatt tcgggtttca
    20761 ccgcggccac ggttcctcct cgtgggaatc tgccgacagt catgggctta acctgtccaa
    20821 cgatagccaa gtgattcttc gcgtcaatag ccaccgaaaa cgggagcagc ggaaccggcg
    20881 caaattacct ttccggccga cctcaacagt tcaatccgcc gggcttttcc gataaatcgc
    20941 gcaaaacgat tccccttaaa gggcgtctga atggcgcaat aaggactgct ataaacaacc
    21001 ggccgcggcg gagctcactc ctggcccctg agcgcaggag gcccgtcccc tggacgagtt
    21061 gactgctcca aggcggccac agcggtcggc agggcgaggt cagcaggcgg gcgaggtggg
    21121 caaccgccca ggaaggtcgg cctacctgga cgggcccaca tccgcgacat tctgaccatg
    21181 accacggcga aggaggagag attgtggaac agcccggacg tgggcagtct ggcggactac
    21241 cggccgggcc ggccgccgcc ggccagtggg cggacctcga aaacgacgcc aagaccacca
    21301 cactgaccgc gcgcccgaag gtgtacgacc tcaagatgga gcaaaccgtc cggccctgct
    21361 gctggccgac gagccgacta tccacgatct agacatccac gacgtgacca agggacaaag
    21421 ccgcaggcta acgagctccg gtccaggtag ccgtggactt gttcaaggtc gcctggccag
    21481 gtgcctgctg gggtggctgc tgtagatcac gcacggtcgg cgcgttcggc cctatctgcg
    21541 tgcccggcca tggccatggc cggggatggg gaacagggac cggctttgga agaggggggt
    21601 agaccggggg gtgccagccc ggccgggggt acgggtagac gtacgggggg cctacggggt
    21661 agccgccccc gacacggacg cattcatact gcgggcaggg cagagtgaag cactgcttgg
    21721 gccggtacac gcagacgtag ccgggtggac acagtacttc gctgcagccg gtcggcgagc
    21781 acgcggctcg gagagccgaa gccgcggccg acggtgctga cgccatcgcc gattcggccg
    21841 gtgtaagacg ggtcgcgtca gccgacgcgg ccaacgcaga aaatggcagc cccgccaaag
    21901 ccgccgtgat gacgaacgtg attcggatca tgatgaatcc ctgaaccctt cttggttccc
    21961 cgatgaaccc cgcactgaat ccgccggcca ttccgtggat tcgcggatat ctcgtgatag
    22021 gccggtcgac ctaccgagat cgtcgcattc gacgaccccc agtccatcgg tggcaacggc
    22081 attatcgagg ccaggaaaca gtaaagatgg tggctatccg aagagggccc taaggtcacc
    22141 gagtgtccgc ccactgctcg gcgccagtca tcagaagtgt ggatattcct ggcggaattg
    22201 cacctgagtt agtgcggcgg ccaggttctc ttgcccaaga cagaggggac gcccgacggc
    22261 actggacaca tattcggtgc tgggtgactc gatgagcaag ccgaaggggc cgggcacctt
    22321 cgcagcgccc ggggcaccat cgtcctgcaa gccgttgacc gcttggcggc ctgccgtaca
    22381 ggtgggtcgc ctgtacttgc tcctcggcac gctggaccgc gccgtgcttc aagcggcgta
    22441 ggtcacgcgc catcgcccgg aggacggcac cgggaagctt cgcttcggtg gctgtaccgg
    22501 agtggaagcc gtgccattcc ggggcgacct ctaattcgcg caatcaggac gacttgccgc
    22561 gaatatcgat atgacaaacc ttcggccgca attttcaggt ggggttggac caagaactcc
    22621 gcgacgccgg gtcgagagtc gggccaggcg aaaaaagctt actaaatggc atcctcatcc
    22681 tggcaaaggg gcgcgtattg gagtgctttc ttccagccct tgagaacaga atgaagagtg
    22741 gctacattga tgaaacgaac cctgctgggc ggcgcgctca ccggggtcgt tctcgtttac
    22801 tcacctgctg cggcaggtgc cgaggcaaag accccctggt cgccaggcca gacggtcacc
    22861 gactatacga cgagcagtac atattctcga gcagcggtgc ggaccccatc cgcggctgct
    22921 cgtgaatgca ttcccgttta ctgcctgccg ccgagcattc aattgattgc gccgccggtc
    22981 cacgtcgagc ccggcacgat cccgctgtgc gcatggcttc acgtgcccca atcgctctgc
    23041 aaggtgccgc cgggtcctgc gggcccgccg ggacccgcgg gtccgcccgg cccagcagga
    23101 cccgcgggtc cccagggacc acctgggcta gacggcctcc ccggcccggc aggccccgcc
    23161 ggtcctgagg gccctcccgg tcttcggggt cccgccggtc ccgctggtcc tcccggtcct
    23221 gagggtgctc cgggtcttcc gggtcctgag ggtcccgccg gtcctgccgg tcctcccggt
    23281 cctga
//
